haemophilus somnus

Summary

Summary: A species of gram-negative bacteria (currently incertae sedis) causing multisystem disease in CATTLE.

Top Publications

  1. Meunier D, Acar J, Martel J, Kroemer S, Valle M. Seven years survey of susceptibility to marbofloxacin of bovine pathogenic strains from eight European countries. Int J Antimicrob Agents. 2004;24:268-78 pubmed
    ..agalactiae, S. dysgalactiae) and respiratory diseases (Mannheimia haemolytica, Pasteurella multocida, Haemophilus somnus). There was no change in the MIC distributions for each species after the launch of marbofloxacin in 1997...
  2. Berghaus L, Corbeil L, Berghaus R, Kalina W, Kimball R, Gershwin L. Effects of dual vaccination for bovine respiratory syncytial virus and Haemophilus somnus on immune responses. Vaccine. 2006;24:6018-27 pubmed
    Bovine respiratory syncytial virus (BRSV) and Haemophilus somnus (H. somnus) co-infect to form a polymicrobial respiratory disease in calves. Both BRSV and H...
  3. Siddaramppa S, Inzana T. Haemophilus somnus virulence factors and resistance to host immunity. Anim Health Res Rev. 2004;5:79-93 pubmed
    b>Haemophilus somnus ('Histophilus somni) is a Gram-negative bacterium and opportunistic pathogen associated with multisystemic diseases of bovines. Some strains of H...
  4. Sylte M, Kuckleburg C, Atapattu D, Leite F, McClenahan D, Inzana T, et al. Signaling through interleukin-1 type 1 receptor diminishes Haemophilus somnus lipooligosaccharide-mediated apoptosis of endothelial cells. Microb Pathog. 2005;39:121-30 pubmed
    ..Our laboratory has demonstrated that Haemophilus somnus, a gram-negative pathogen of cattle that causes sepsis and vasculitis, and its lipooligosaccharide (LOS) ..
  5. Tagawa Y, Sanders J, Uchida I, Bastida Corcuera F, Kawashima K, Corbeil L. Genetic and functional analysis of Haemophilus somnus high molecular weight-immunoglobulin binding proteins. Microb Pathog. 2005;39:159-70 pubmed
    b>Haemophilus somnus immunoglobulin binding proteins (IgBPs) are virulence associated but only one (p76) has been genetically defined. We determined the nucleotide sequence of the 5'-flanking region of the p76 gene...
  6. St Michael F, Li J, Howard M, Duncan A, Inzana T, Cox A. Structural analysis of the oligosaccharide of Histophilus somni (Haemophilus somnus) strain 2336 and identification of several lipooligosaccharide biosynthesis gene homologues. Carbohydr Res. 2005;340:665-72 pubmed
    The structure of the core oligosaccharide from a pneumonic Histophilus somni (Haemophilus somnus) strain 2336 was elucidated. The lipooligosaccharide (LOS) was subjected to a variety of degradative procedures...
  7. Ward A, Weiser G, Anderson B, Cummings P, Arnold K, Corbeil L. Haemophilus somnus (Histophilus somni) in bighorn sheep. Can J Vet Res. 2006;70:34-42 pubmed
    ..b>Haemophilus somnus (recently reclassified as Histophilus somni) is associated with respiratory disease in American bison, ..
  8. Corbeil L. Histophilus somni host-parasite relationships. Anim Health Res Rev. 2007;8:151-60 pubmed publisher
    Histophilus somni (Haemophilus somnus) is one of the key bacterial pathogens involved in the multifactorial etiology of the Bovine Respiratory Disease Complex...
  9. Ekins A, Bahrami F, Sijercic A, Maret D, Niven D. Haemophilus somnus possesses two systems for acquisition of transferrin-bound iron. J Bacteriol. 2004;186:4407-11 pubmed
    b>Haemophilus somnus strain 649 was found to acquire iron from ovine, bovine, and goat transferrins (Tfs)...

More Information

Publications53

  1. Geertsema R, Kimball R, Corbeil L. Bovine plasma proteins increase virulence of Haemophilus somnus in mice. Microb Pathog. 2007;42:22-8 pubmed
    The role of bovine serum or plasma proteins in Haemophilus somnus virulence was investigated in a mouse model of septicemia...
  2. Reeks B, Champlin F, Paulsen D, Scruggs D, Lawrence M. Effects of sub-minimum inhibitory concentration antibiotic levels and temperature on growth kinetics and outer membrane protein expression in Mannheimia haemolytica and Haemophilus somnus. Can J Vet Res. 2005;69:1-10 pubmed
    ..CTC + SMZ), on growth kinetics and outer membrane protein expression in Mannheimia haemolytica and Haemophilus somnus at normal and febrile body temperatures...
  3. Gershwin L, Berghaus L, Arnold K, Anderson M, Corbeil L. Immune mechanisms of pathogenetic synergy in concurrent bovine pulmonary infection with Haemophilus somnus and bovine respiratory syncytial virus. Vet Immunol Immunopathol. 2005;107:119-30 pubmed
    Bovine respiratory syncytial virus (BRSV) and Haemophilus somnus are two bovine respiratory pathogens that cause disease singly or as part of a polymicrobial infection...
  4. Czuprynski C, Leite F, Sylte M, Kuckleburg C, Schultz R, Inzana T, et al. Complexities of the pathogenesis of Mannheimia haemolytica and Haemophilus somnus infections: challenges and potential opportunities for prevention?. Anim Health Res Rev. 2004;5:277-82 pubmed
    ..has been involved in investigations of two members of the family Pasteurellaceae, Mannheimia haemolytica and Haemophilus somnus, which illustrate some of the complexities that must be confronted. Susceptibility to M...
  5. Behling Kelly E, Vonderheid H, Kim K, Corbeil L, Czuprynski C. Roles of cellular activation and sulfated glycans in Haemophilus somnus adherence to bovine brain microvascular endothelial cells. Infect Immun. 2006;74:5311-8 pubmed
    b>Haemophilus somnus can cause a devastating fibrinopurulent meningitis with thrombotic vasculitis and encephalitis in cattle. The mechanisms used by H...
  6. Kuckleburg C, Sylte M, Inzana T, Corbeil L, Darien B, Czuprynski C. Bovine platelets activated by Haemophilus somnus and its LOS induce apoptosis in bovine endothelial cells. Microb Pathog. 2005;38:23-32 pubmed
    b>Haemophilus somnus is a bacterial pathogen that causes respiratory disease and vasculitis in cattle. Thrombotic meningoencephalitis (TME) and other severe forms of H...
  7. Siddaramappa S, Duncan A, Brettin T, Inzana T. Comparative analyses of two cryptic plasmids from Haemophilus somnus (Histophilus somni). Plasmid. 2006;55:227-34 pubmed
    b>Haemophilus somnus is an opportunistic bacterial pathogen capable of causing pneumonia, septicemia, and other systemic infections in bovines. An H. somnus isolate from bovine abortion (strain 649) was found to carry a approximately 1...
  8. Challacombe J, Duncan A, Brettin T, Bruce D, Chertkov O, Detter J, et al. Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd. J Bacteriol. 2007;189:1890-8 pubmed
    b>Haemophilus somnus can be either a commensal of bovine mucosal surfaces or an opportunistic pathogen. Pathogenic strains of H. somnus are a significant cause of systemic disease in cattle. We report the genome sequence of H...
  9. Sylte M, Inzana T, Czuprynski C. Reactive oxygen and nitrogen intermediates contribute to Haemophilus somnus lipooligosaccharide-mediated apoptosis of bovine endothelial cells. Vet Immunol Immunopathol. 2004;97:207-17 pubmed
    Although Haemophilus somnus causes septicemia and vasculitis in cattle, relatively little is known about how H. somnus affects endothelial cells in vitro. We previously reported that H...
  10. Sylte M, Kuckleburg C, Leite F, Inzana T, Czuprynski C. Tumor necrosis factor-alpha enhances Haemophilus somnus lipooligosaccharide-induced apoptosis of bovine endothelial cells. Vet Immunol Immunopathol. 2006;110:303-9 pubmed
    b>Haemophilus somnus lipooligosaccharide (LOS)-induced apoptosis of bovine pulmonary artery endothelial cells has been shown previously to be dependent on caspase-8 activation...
  11. Behling Kelly E, Kim K, Czuprynski C. Haemophilus somnus activation of brain endothelial cells: potential role for local cytokine production and thrombosis in central nervous system (CNS) infection. Thromb Haemost. 2007;98:823-30 pubmed
    ..The etiologic agent of TME is Haemophilus somnus, a gram-negative pleomorphic coccobacillus...
  12. Elswaifi S, Scarratt W, Inzana T. The role of lipooligosaccharide phosphorylcholine in colonization and pathogenesis of Histophilus somni in cattle. Vet Res. 2012;43:49 pubmed publisher
    ..In conclusion, expression of ChoP on H. somni LOS contributed to colonization of the bacteria to the host upper respiratory tract, but phase variable loss of ChoP expression may help the bacteria survive systemically...
  13. Kuckleburg C, McClenahan D, Czuprynski C. Platelet activation by Histophilus somni and its lipooligosaccharide induces endothelial cell proinflammatory responses and platelet internalization. Shock. 2008;29:189-96 pubmed
    ..These findings suggest that activated platelets might play a role in promoting vascular inflammation during H. somni infection...
  14. Khan M, Tanaka A, Ide H, Hoshinoo K, Hanafusa Y, Tagawa Y. Molecular characterization of the major outer membrane protein of Haemophilus somnus. Vet Microbiol. 2005;107:179-92 pubmed
    The major outer membrane protein (MOMP) of Haemophilus somnus shows antigenic and molecular mass diversity that forms the basis of a preliminary grouping system for H. somnus strains. In this study, the gene encoding MOMP of H...
  15. Briggs R, Tatum F. Generation and molecular characterization of new temperature-sensitive plasmids intended for genetic engineering of Pasteurellaceae. Appl Environ Microbiol. 2005;71:7187-95 pubmed
    ..Replication of the TS plasmids was thermoregulated in Pasteurella multocida and Haemophilus somnus as well. To consistently transform H...
  16. Howard M, Willis L, Wakarchuk W, St Michael F, Cox A, Horne W, et al. Genetics and molecular specificity of sialylation of Histophilus somni lipooligosaccharide (LOS) and the effect of LOS sialylation on Toll-like receptor-4 signaling. Vet Microbiol. 2011;153:163-72 pubmed publisher
    ..Therefore, sialylation inhibited LOS signaling through TLR-4. In conclusion, H. somni utilizes linkage-specific sialyltransferases to sialylate its LOS to avoid innate host defense mechanisms despite simultaneous epitope phase variation...
  17. Aarestrup F, Seyfarth A, Angen Ø. Antimicrobial susceptibility of Haemophilus parasuis and Histophilus somni from pigs and cattle in Denmark. Vet Microbiol. 2004;101:143-6 pubmed
    ..This study showed that Danish isolates of H. parasuis and H. somni in general are fully susceptible to antimicrobial agents currently used for treatment of infections with these pathogens...
  18. Kuckleburg C, Tiwari R, Czuprynski C. Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species. Thromb Haemost. 2008;99:363-72 pubmed publisher
    ..b>Haemophilus somnus is a bacterial pathogen that causes diffuse vascular inflammation and endothelial damage. In some cases H...
  19. Doungudomdacha S, Volgina A, DiRienzo J. Evidence that the cytolethal distending toxin locus was once part of a genomic island in the periodontal pathogen Aggregatibacter (Actinobacillus) actinomycetemcomitans strain Y4. J Med Microbiol. 2007;56:1519-27 pubmed
    ..islands in Haemophilus ducreyi 35000HP and Haemophilus influenzae 86-028NP and to a chromosomal region in Haemophilus somnus 129PT. GIY4-1 was not present in HK1651, which was used as the prototype strain for genomic sequencing of A...
  20. Behling Kelly E, Czuprynski C. Endothelial cells as active participants in veterinary infections and inflammatory disorders. Anim Health Res Rev. 2007;8:47-58 pubmed
    ..A select group of viral and bacterial pathogens will be used as examples to demonstrate how endothelial cell dysfunction contributes to the pathogenesis of infectious and inflammatory disorders...
  21. Kumar R, Lawrence M, Watt J, Cooksey A, Burgess S, Nanduri B. RNA-seq based transcriptional map of bovine respiratory disease pathogen "Histophilus somni 2336". PLoS ONE. 2012;7:e29435 pubmed publisher
    ..This observation suggests that a number of the newly identified sRNAs in strain 2336 may be involved in strain-specific adaptations...
  22. Inzana T, Balyan R, Howard M. Decoration of Histophilus somni lipooligosaccharide with N-acetyl-5-neuraminic acid enhances bacterial binding of complement factor H and resistance to killing by serum and polymorphonuclear leukocytes. Vet Microbiol. 2012;161:113-21 pubmed publisher
    ..Therefore, sialylation of H. somni LOS had profound effects on resistance of the bacteria to innate bovine host defenses, which should be taken into consideration during in vitro studies of H. somni...
  23. Sandal I, Inzana T, Molinaro A, De Castro C, Shao J, Apicella M, et al. Identification, structure, and characterization of an exopolysaccharide produced by Histophilus somni during biofilm formation. BMC Microbiol. 2011;11:186 pubmed publisher
    ..somni. However, H. somni does form a biofilm in vitro and in vivo, and the biofilm matrix of most bacteria consists of a polysaccharide...
  24. Rowan T, Sarasola P, Sunderland S, Giles C, Smith D. Efficacy of danofloxacin in the treatment of respiratory disease in European cattle. Vet Rec. 2004;154:585-9 pubmed
    ..Mannheimia haemolytica, Pasteurella multocida and Haemophilus somnus were isolated from pretreatment nasopharyngeal swabs taken on all the farms...
  25. Zekarias B, O Toole D, Lehmann J, Corbeil L. Histophilus somni IbpA Fic cytotoxin is conserved in disease strains and most carrier strains from cattle, sheep and bison. Vet Microbiol. 2011;149:177-85 pubmed publisher
    ..Conservation of the protective IbpA antigen in all disease isolates tested is encouraging for development of protective vaccines and diagnostic assays...
  26. Tiwari R, Sullivan J, Czuprynski C. PECAM-1 is involved in neutrophil transmigration across Histophilus somni treated bovine brain endothelial cells. Microb Pathog. 2009;47:164-70 pubmed publisher
    ..Confocal microscopy indicated that H. somni treatment leads to redistribution of PECAM-1 and eNOS on the surface of TBBEC. These findings suggest that PECAM-1 and eNOS may play a role in the early pathogenesis of TME...
  27. Tatum F, Briggs R. Construction of in-frame aroA deletion mutants of Mannheimia haemolytica, Pasteurella multocida, and Haemophilus somnus by using a new temperature-sensitive plasmid. Appl Environ Microbiol. 2005;71:7196-202 pubmed
    ..and used to engineer in-frame aroA deletion mutants of Mannheimia hemolytica, Pasteurella multocida, and Haemophilus somnus. TS replacement plasmids carrying in-frame aroA deletions were constructed for each target species and ..
  28. McDougall S. Gross abnormalities, bacteriology and histological lesions of uteri of dairy cows failing to conceive or maintain pregnancy. N Z Vet J. 2005;53:253-6 pubmed
    ..To describe the gross pathology, bacteriology and histopathology of the reproductive tracts of dairy cows that failed to conceive or maintain pregnancy...
  29. Headley S, Oliveira V, Figueira G, Bronkhorst D, Alfieri A, Okano W, et al. Histophilus somni-induced infections in cattle from southern Brazil. Trop Anim Health Prod. 2013;45:1579-88 pubmed publisher
    ..These findings confirm the participation of H. somni in the pathological alterations observed in this study and represent the first description of histophilosis in cattle from Brazil...
  30. Cho Y, Lee H, Lim S, Joo Y, Kim J, Kim J. Safety and efficacy testing of a novel multivalent bovine bacterial respiratory vaccine composed of five bacterins and two immunogens. J Vet Med Sci. 2008;70:959-64 pubmed
    ..haemolytica type A, outer membrane protein and bacterin of Pasteurella multocida type A, and bacterins of Haemophilus somnus, Mycoplasma bovis, and Arcanobacterium pyogenes...
  31. Tesfaye B, Sisay Tessema T, Tefera G. Diversity of bacterial species in the nasal cavity of sheep in the highlands of Ethiopia and first report of Histophilus somni in the country. Trop Anim Health Prod. 2013;45:1243-9 pubmed publisher
    ..To our knowledge, this is the first report on isolation of H. somni, an important pathogen in cattle, from the respiratory tract of a ruminant species in the country...
  32. Behling Kelly E, McClenahan D, Kim K, Czuprynski C. Viable "Haemophilus somnus" induces myosin light-chain kinase-dependent decrease in brain endothelial cell monolayer resistance. Infect Immun. 2007;75:4572-81 pubmed
    quot;Haemophilus somnus" causes thrombotic meningoencephalitis in cattle. Our laboratory has previously reported that H. somnus has the ability to adhere to, but not invade, bovine brain endothelial cells (BBEC) in vitro...
  33. Haines D, Moline K, Sargent R, Campbell J, Myers D, Doig P. Immunohistochemical study of Hemophilus somnus, Mycoplasma bovis, Mannheimia hemolytica, and bovine viral diarrhea virus in death losses due to myocarditis in feedlot cattle. Can Vet J. 2004;45:231-4 pubmed
    ..The findings also suggest that BVDV is an important pathogen in calves dying with gross postmortem lesions of pneumonia...
  34. Godinho K. Susceptibility testing of tulathromycin: interpretative breakpoints and susceptibility of field isolates. Vet Microbiol. 2008;129:426-32 pubmed publisher
    ..The use of recently established interpretative breakpoints would indicate that to date there has been no apparent decrease in susceptibility to tulathromycin since it became widely used across Europe...
  35. Pérez Romero N, Aguilar Romero F, Arellano Reynoso B, Díaz Aparicio E, Hernández Castro R. Isolation of Histophilus somni from the nasal exudates of a clinically healthy adult goat. Trop Anim Health Prod. 2011;43:901-3 pubmed publisher
    ..This strain was identified according to its phenotypic characteristics and by means of a species-specific polymerase chain reaction (PCR), as well as by sequencing of the amplified product...
  36. Corbeil L, Arnold K, Kimball R, Berghaus L, Gershwin L. Specificity of IgG and IgE antibody responses to Haemophilus somnus infection of calves. Vet Immunol Immunopathol. 2006;113:191-9 pubmed
    b>Haemophilus somnus is an important cause of bovine respiratory disease and septicemia with all it's sequelae. The role of immune responses in protection and immunopathogenesis is not well understood...
  37. Sylte M, Kuckleburg C, Inzana T, Bertics P, Czuprynski C. Stimulation of P2X receptors enhances lipooligosaccharide-mediated apoptosis of endothelial cells. J Leukoc Biol. 2005;77:958-65 pubmed
    ..the role that P2X receptors play in the apoptosis that follows exposure of bovine endothelial cells to Haemophilus somnus LOS...
  38. Godinho K, Wolf R, Sherington J, Rowan T, Sunderland S, Evans N. Efficacy of tulathromycin in the treatment and prevention of natural outbreaks of bovine respiratory disease in European cattle. Vet Ther. 2005;6:122-35 pubmed
    ..7%) or saline-treated (63.7%) cattle, and this was maintained through day 60 (tulathromycin 85.4% versus tilmicosin 75.1% and saline 56.2%). Tulathromycin was highly effective in the treatment and prevention of BRD...
  39. Godinho K, Keane S, Nanjiani I, Benchaoui H, Sunderland S, Jones M, et al. Minimum inhibitory concentrations of tulathromycin against respiratory bacterial pathogens isolated from clinical cases in European cattle and swine and variability arising from changes in in vitro methodology. Vet Ther. 2005;6:113-21 pubmed
    ..5 to 4 microg/ml for Histophilus somni (Haemophilus somnus) and from 4 to 16 microg/ml for Actinobacillus pleuropneumoniae...
  40. Berry B, Krehbiel C, Confer A, Gill D, Smith R, Montelongo M. Effects of dietary energy and starch concentrations for newly received feedlot calves: I. Growth performance and health. J Anim Sci. 2004;82:837-44 pubmed
    ..multocida during the first antimicrobial treatment and a lower percentage of Haemophilus somnus isolates during the first (P = 0.01) and second (P = 0...
  41. Semple J. Platelets play a direct role in sepsis-associated endothelial cell death. Thromb Haemost. 2008;99:249 pubmed publisher
  42. Sylte M, Leite F, Kuckleburg C, Inzana T, Czuprynski C. Caspase activation during Haemophilus somnus lipooligosaccharide-mediated apoptosis of bovine endothelial cells. Microb Pathog. 2003;35:285-91 pubmed
    Vasculitis is commonly seen during systemic Haemophilus somnus infections. Although, the mechanism of vascular damage is not completely understood, in a previous report we demonstrated that H...
  43. Gagea M, Bateman K, van Dreumel T, McEwen B, Carman S, Archambault M, et al. Diseases and pathogens associated with mortality in Ontario beef feedlots. J Vet Diagn Invest. 2006;18:18-28 pubmed
    ..M. bovis pneumonia and polyarthritis has emerged as an important cause of mortality in Ontario beef feedlots...
  44. St Michael F, Inzana T, Cox A. Structural analysis of the lipooligosaccharide-derived oligosaccharide of Histophilus somni (Haemophilus somnus) strain 8025. Carbohydr Res. 2006;341:281-4 pubmed
    ..Since genetic manipulation has been achieved with this strain, the identification of the core OS structure will enable experiments designed to identify the role of glycosyltransferases involved in LOS biosynthesis...