lactobacillus casei

Summary

Summary: A rod-shaped bacterium isolated from milk and cheese, dairy products and dairy environments, sour dough, cow dung, silage, and human mouth, human intestinal contents and stools, and the human vagina.

Top Publications

  1. Rodriguez Diaz J, Rubio Del Campo A, Yebra M. Lactobacillus casei ferments the N-Acetylglucosamine moiety of fucosyl-?-1,3-N-acetylglucosamine and excretes L-fucose. Appl Environ Microbiol. 2012;78:4613-9 pubmed publisher
    We have previously characterized from Lactobacillus casei BL23 three ?-L-fucosidases, AlfA, AlfB, and AlfC, which hydrolyze in vitro natural fucosyl-oligosaccharides. In this work, we have shown that L...
  2. Varyukhina S, Freitas M, Bardin S, Robillard E, Tavan E, Sapin C, et al. Glycan-modifying bacteria-derived soluble factors from Bacteroides thetaiotaomicron and Lactobacillus casei inhibit rotavirus infection in human intestinal cells. Microbes Infect. 2012;14:273-8 pubmed publisher
    ..soluble factors that increase cell-surface galactose namely, those of Bacteroides thetaiotaomicron and Lactobacillus casei were able to efficiently block rotavirus infections...
  3. Adachi K, Kawana K, Yokoyama T, Fujii T, Tomio A, Miura S, et al. Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7. Vaccine. 2010;28:2810-7 pubmed publisher
    ..mucosal cytotoxic cellular immune responses to HPV16 E7 after oral immunization of mice with recombinant Lactobacillus casei expressing HPV16 E7 (LacE7). C57BL/6 mice were orally exposed to 0...
  4. Yoon S, Lee T, Kim S, Lee I, Sung M, Park J, et al. Oral administration of HPV-16 L2 displayed on Lactobacillus casei induces systematic and mucosal cross-neutralizing effects in Balb/c mice. Vaccine. 2012;30:3286-94 pubmed publisher
    ..A (pgsA) protein to display a partial HPV-16 L2 protein (N-terminal 1-224 amino acid) on the surface of Lactobacillus casei (L. casei). The oral immunization with L...
  5. de Moreno de Leblanc A, Dogi C, Galdeano C, Carmuega E, Weill R, Perdigon G. Effect of the administration of a fermented milk containing Lactobacillus casei DN-114001 on intestinal microbiota and gut associated immune cells of nursing mice and after weaning until immune maturity. BMC Immunol. 2008;9:27 pubmed publisher
    ..of a probiotic fermented milk (PFM) containing yogurt starter cultures and the probiotic bacteria strain Lactobacillus casei DN-114001 to mothers during nursing or their offspring, on the intestinal bacterial population and on ..
  6. Baba N, Samson S, Bourdet Sicard R, Rubio M, Sarfati M. Selected commensal-related bacteria and Toll-like receptor 3 agonist combinatorial codes synergistically induce interleukin-12 production by dendritic cells to trigger a T helper type 1 polarizing programme. Immunology. 2009;128:e523-31 pubmed publisher
    ..We identified a unique combination of Lactobacillus casei and TLR3 signals that acted in synergy to selectively increase IL-12p70 secretion...
  7. Almeida C, Lorena S, Pavan C, Akasaka H, Mesquita M. Beneficial effects of long-term consumption of a probiotic combination of Lactobacillus casei Shirota and Bifidobacterium breve Yakult may persist after suspension of therapy in lactose-intolerant patients. Nutr Clin Pract. 2012;27:247-51 pubmed publisher
    ..To evaluate the effects of a 4-week consumption of a probiotic product containing Lactobacillus casei Shirota and Bifidobacterium breve Yakult (10(7)-10(9) CFU of each strain) on symptoms and breath hydrogen ..
  8. Kmoníčková E, Kverka M, Tlaskalova Hogenova H, Kostecká P, Zidek Z. Stimulation of nitric oxide, cytokine and prostaglandin production by low-molecular weight fractions of probiotic Lactobacillus casei lysate. Neuro Endocrinol Lett. 2012;33 Suppl 3:166-72 pubmed
    ..b>Lactobacillus casei probiotic strain DN-114001 was employed...
  9. De Boeck R, Sarmiento Rubiano L, Nadal I, Monedero V, Perez Martinez G, Yebra M. Sorbitol production from lactose by engineered Lactobacillus casei deficient in sorbitol transport system and mannitol-1-phosphate dehydrogenase. Appl Microbiol Biotechnol. 2010;85:1915-22 pubmed publisher
    ..We have previously described a sorbitol-producing Lactobacillus casei (strain BL232) in which the gutF gene, encoding a sorbitol-6-phosphate dehydrogenase, was expressed from ..

More Information

Publications86

  1. Castillo N, Perdigon G, de Moreno de Leblanc A. Oral administration of a probiotic Lactobacillus modulates cytokine production and TLR expression improving the immune response against Salmonella enterica serovar Typhimurium infection in mice. BMC Microbiol. 2011;11:177 pubmed publisher
    ..Previously we demonstrated that continuous Lactobacillus casei CRL 431 administration to BALB/c mice before and after challenge with Salmonella enterica serovar ..
  2. Regulski K, Courtin P, Kulakauskas S, Chapot Chartier M. A novel type of peptidoglycan-binding domain highly specific for amidated D-Asp cross-bridge, identified in Lactobacillus casei bacteriophage endolysins. J Biol Chem. 2013;288:20416-26 pubmed publisher
    ..We have characterized two endolysins, Lc-Lys and Lc-Lys-2, identified in prophages present in the genome of Lactobacillus casei BL23. These two enzymes have different catalytic domains but similar putative C-terminal CWBDs...
  3. Braga T, da Silva G, de Lira P, de Carvalho Lima M. Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial. Am J Clin Nutr. 2011;93:81-6 pubmed publisher
    ..The objective was to assess whether the combined use of Lactobacillus casei and Bifidobacterium breve may prevent the occurrence of NEC stage ? 2 by the criteria of Bell in very-low-..
  4. So J, Song M, Kwon H, Lee C, Chae C, Sahoo A, et al. Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis. Life Sci. 2011;88:358-66 pubmed publisher
    We previously reported that Lactobacillus casei (L. casei) has beneficial effects in experimental rheumatoid arthritis (RA) by suppressing inflammatory immune responses...
  5. Zakostelska Z, Kverka M, Klimesova K, Rossmann P, Mrazek J, Kopecny J, et al. Lysate of probiotic Lactobacillus casei DN-114 001 ameliorates colitis by strengthening the gut barrier function and changing the gut microenvironment. PLoS ONE. 2011;6:e27961 pubmed publisher
    ..Our study provided evidence that even non-living probiotic bacteria can prevent the development of severe forms of intestinal inflammation by strengthening the integrity of intestinal barrier and modulation of gut microenvironment. ..
  6. Wang Y, Li Y, Xie J, Zhang Y, Wang J, Sun X, et al. Protective effects of probiotic Lactobacillus casei Zhang against endotoxin- and d-galactosamine-induced liver injury in rats via anti-oxidative and anti-inflammatory capacities. Int Immunopharmacol. 2013;15:30-7 pubmed publisher
    b>Lactobacillus casei Zhang (LcZ) has been recently isolated from the traditional Mongolian beverage koumiss and has a set of favorable probiotic properties, including aciduricity, bile resistance and ability to colonize the ..
  7. Broadbent J, Neeno Eckwall E, Stahl B, Tandee K, Cai H, Morovic W, et al. Analysis of the Lactobacillus casei supragenome and its influence in species evolution and lifestyle adaptation. BMC Genomics. 2012;13:533 pubmed publisher
    ..Additionally, our data confirm the Distributed Genome Hypothesis extends to non-pathogenic, ecologically flexible species like L. casei. ..
  8. de Jonge J, Ezendam J, Knippels L, Penninks A, Pieters R, Van Loveren H. Lactobacillus casei Shirota does not decrease the food allergic response to peanut extract in Brown Norway rats. Toxicology. 2008;249:140-5 pubmed publisher
    ..We investigated whether the probiotic Lactobacillus casei Shirota (LcS) could modulate the food allergic response against peanut extract (PE) in Brown Norway (BN) ..
  9. Shukla G, Sidhu R, Verma A. Restoration of anthropometric, biochemical and histopathological alterations by Lactobacillus casei supplementation in Giardia intestinalis infected renourished BALB/c mice. Antonie Van Leeuwenhoek. 2012;102:61-72 pubmed publisher
    The present study describes the in vivo ameliorating effect of Lactobacillus casei supplementation in renourished Giardia intestinalis infected BALB/c mice...
  10. Fang H, Fang S, Chiang Chiau J, Yeung C, Chan W, Jiang C, et al. Inhibitory effects of Lactobacillus casei subsp. rhamnosus on Salmonella lipopolysaccharide-induced inflammation and epithelial barrier dysfunction in a co-culture model using Caco-2/peripheral blood mononuclear cells. J Med Microbiol. 2010;59:573-9 pubmed publisher
    In this study, we investigated the anti-inflammatory and reinforcing barrier effects of Lactobacillus casei subsp. rhamnosus (Lcr35) on Caco-2 intestinal epithelial cells already exposed to Salmonella LPS...
  11. Zhang W, Yu D, Sun Z, Chen X, Bao Q, Meng H, et al. Complete nucleotide sequence of plasmid plca36 isolated from Lactobacillus casei Zhang. Plasmid. 2008;60:131-5 pubmed publisher
    The complete 36,487 bp sequence of plasmid plca36 from Lactobacillus casei Zhang was determined. Plca36 contains 44 predicted coding regions, and to 23 of them functions could be assigned...
  12. Rochet V, Rigottier Gois L, Levenez F, Cadiou J, Marteau P, Bresson J, et al. Modulation of Lactobacillus casei in ileal and fecal samples from healthy volunteers after consumption of a fermented milk containing Lactobacillus casei DN-114 001Rif. Can J Microbiol. 2008;54:660-7 pubmed publisher
    b>Lactobacillus casei DN-114 001 is a probiotic strain able to interact with the immune system and to interfere with gastrointestinal pathogens...
  13. Naito E, Yoshida Y, Makino K, Kounoshi Y, Kunihiro S, Takahashi R, et al. Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice. J Appl Microbiol. 2011;110:650-7 pubmed publisher
    This study aimed at determining whether oral administration of a probiotic strain, Lactobacillus casei strain Shirota (LcS), can improve insulin resistance, which is the underlying cause of obesity-associated metabolic abnormalities, in ..
  14. Jain S, Yadav H, Sinha P. Probiotic dahi containing Lactobacillus casei protects against Salmonella enteritidis infection and modulates immune response in mice. J Med Food. 2009;12:576-83 pubmed publisher
    In the present study, effect of dahi containing probiotic Lactobacillus casei (probiotic dahi) was evaluated to modulate immune response against Salmonella enteritidis infection in mice...
  15. Schulte D, Yilmaz A, Shimada K, Fishbein M, Lowe E, Chen S, et al. Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease. J Immunol. 2009;183:5311-8 pubmed publisher
    ..Injection of a cell wall extract isolated from Lactobacillus casei (LCCWE) into mice causes a focal coronary arteritis that histopathologically mimics the coronary lesions ..
  16. Ashraf R, Shah N. Selective and differential enumerations of Lactobacillus delbrueckii subsp. bulgaricus, Streptococcus thermophilus, Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium spp. in yoghurt--a review. Int J Food Microbiol. 2011;149:194-208 pubmed publisher
    ..and Lb. casei. Bifidobacterium could be enumerated on MRS agar supplemented with nalidixic acid, paromomycin, neomycin sulphate and lithium chloride (MRS-NPNL) under anaerobic incubation at 37°C for 72h...
  17. Villena J, Salva S, Agüero G, Alvarez S. Immunomodulatory and protective effect of probiotic Lactobacillus casei against Candida albicans infection in malnourished mice. Microbiol Immunol. 2011;55:434-45 pubmed publisher
    The effect of Lactobacillus casei CRL 431 (Lc), when administered as a supplement to a repletion diet, on the resistance of malnourished mice to Candida albicans infection was studied...
  18. Nanno M, Kato I, Kobayashi T, Shida K. Biological effects of probiotics: what impact does Lactobacillus casei shirota have on us?. Int J Immunopathol Pharmacol. 2011;24:45S-50S pubmed
    ..To evaluate the effect of probiotics on the prevention of carcinogenesis, Lactobacillus casei Shirota (LcS) was given to the patients who had undergone the resection of superficial bladder cancer, and ..
  19. D Arienzo R, Maurano F, Luongo D, Mazzarella G, Stefanile R, Troncone R, et al. Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity. Immunol Lett. 2008;119:78-83 pubmed publisher
    ..In this study we explored the effect of Lactobacillus casei in transgenic mice expressing the human DQ8 heterodimer, a HLA molecule linked to Celiac Disease (CD)...
  20. Ribelles P, Rodr guez I, Su rez J. LysA2, the Lactobacillus casei bacteriophage A2 lysin is an endopeptidase active on a wide spectrum of lactic acid bacteria. Appl Microbiol Biotechnol. 2012;94:101-10 pubmed publisher
    The lysin gene (lysA2) of the Lactobacillus casei bacteriophage A2 was cloned and expressed in Escherichia coli...
  21. Barrett J, Canale K, Gearry R, Irving P, Gibson P. Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome. World J Gastroenterol. 2008;14:5020-4 pubmed
    To determine whether Lactobacillus casei strain Shirota (Yakult) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel ..
  22. Chen C, Ai L, Zhou F, Wang L, Zhang H, Chen W, et al. Complete genome sequence of the probiotic bacterium Lactobacillus casei LC2W. J Bacteriol. 2011;193:3419-20 pubmed publisher
    b>Lactobacillus casei LC2W, a patented probiotic strain (Z. Wu, European patent EP 1642963 B1, February 2009), has been isolated from Chinese traditional dairy products and implemented in industrial production as starter culture...
  23. Huang C, Chang M, Huang M, Lee F. Application of the SNaPshot minisequencing assay to species identification in the Lactobacillus casei group. Mol Cell Probes. 2011;25:153-7 pubmed publisher
    ..study used group-specific PCR combined with SNaPshot minisequencing for species identification within the Lactobacillus casei group. The L. casei group-specific PCR primer pair was designed using the rpoA gene sequence...
  24. Shukla G, Sidhu R. Lactobacillus casei as a probiotic in malnourished Giardia lamblia-infected mice: a biochemical and histopathological study. Can J Microbiol. 2011;57:127-35 pubmed publisher
    The study describes the in vivo activity of Lactobacillus casei in malnourished Giardia lamblia-infected BALB/c mice...
  25. Campos I, Darrieux M, Ferreira D, Miyaji E, Silva D, Arêas A, et al. Nasal immunization of mice with Lactobacillus casei expressing the Pneumococcal Surface Protein A: induction of antibodies, complement deposition and partial protection against Streptococcus pneumoniae challenge. Microbes Infect. 2008;10:481-8 pubmed publisher
    ..In this work, the N-terminal region of clade 1 PspA was constitutively expressed in Lactobacillus casei and the recombinant bacteria was tested as a mucosal vaccine in mice. Nasal immunization with L...
  26. Bogicevic B, Berthoud H, Portmann R, Meile L, Irmler S. CysK from Lactobacillus casei encodes a protein with O-acetylserine sulfhydrylase and cysteine desulfurization activity. Appl Microbiol Biotechnol. 2012;94:1209-20 pubmed publisher
    A gene encoding an O-acetyl-L-serine sulfhydrylase (cysK) was cloned from Lactobacillus casei FAM18110 and expressed in Escherichia coli. The purified recombinant enzyme synthesized cysteine from sulfide and O-acetyl-L-serine at pH 5...
  27. Serata M, Iino T, Yasuda E, Sako T. Roles of thioredoxin and thioredoxin reductase in the resistance to oxidative stress in Lactobacillus casei. Microbiology. 2012;158:953-62 pubmed publisher
    The Lactobacillus casei strain Shirota used in this study has in the genome four putative thioredoxin genes designated trxA1, trxA2, trxA3 and trxA4, and one putative thioredoxin reductase gene designated trxB...
  28. Mazé A, Boel G, Zúñiga M, Bourand A, Loux V, Yebra M, et al. Complete genome sequence of the probiotic Lactobacillus casei strain BL23. J Bacteriol. 2010;192:2647-8 pubmed publisher
    The entire genome of Lactobacillus casei BL23, a strain with probiotic properties, has been sequenced. The genomes of BL23 and the industrially used probiotic strain Shirota YIT 9029 (Yakult) seem to be very similar.
  29. Ito M, Kim Y, Tsuji H, Kiwaki M, Nomoto K, Tanaka R, et al. A practical random mutagenesis system for probiotic Lactobacillus casei using Tn5 transposition complexes. J Appl Microbiol. 2010;109:657-66 pubmed publisher
    Despite the fact that the entire genome sequence of probiotic Lactobacillus casei has recently been available, their mechanisms of beneficial effects are poorly clarified, probably because of the lack of an efficient mutagenesis system...
  30. Bellavia M, Rappa F, Lo Bello M, Brecchia G, Tomasello G, Leone A, et al. Lactobacillus casei and bifidobacterium lactis supplementation reduces tissue damage of intestinal mucosa and liver after 2,4,6-trinitrobenzenesulfonic acid treatment in mice. J Biol Regul Homeost Agents. 2014;28:251-61 pubmed
    ..In the second step, mice treated, or not, with TNBS inoculation, were treated with PB (Lactobacillus Casei, Bifidobacterum Lactis) for 1, 2 or 3 weeks, on a daily basis...
  31. Ge X, Qian H, Zhang W. Enhancement of L-lactic acid production in Lactobacillus casei from Jerusalem artichoke tubers by kinetic optimization and citrate metabolism. J Microbiol Biotechnol. 2010;20:101-9 pubmed
    Efficient L-lactic acid production from Jerusalem artichoke tubers by Lactobacillus casei G-02 using simultaneous saccharification and fermentation (SSF) in fed-batch culture is demonstrated...
  32. Yadav H, Jain S, Sinha P. The effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei on gastropathic consequences in diabetic rats. J Med Food. 2008;11:62-8 pubmed publisher
    ..study, the effects of oral administration of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei on gastropathic consequences in streptozotocin-induced diabetic rats were evaluated, and effects were ..
  33. Oishi K, Sato T, Yokoi W, Yoshida Y, Ito M, Sawada H. Effect of probiotics, Bifidobacterium breve and Lactobacillus casei, on bisphenol A exposure in rats. Biosci Biotechnol Biochem. 2008;72:1409-15 pubmed
    ..In this study, we evaluated whether the probiotics, Bifidobacterium breve strain Yakult (BbY) and Lactobacillus casei strain Shirota (LcS), could exert a protective effect against dietary exposure to BPA...
  34. Munoz Provencio D, Llopis M, Antolin M, de Torres I, Guarner F, Perez Martinez G, et al. Adhesion properties of Lactobacillus casei strains to resected intestinal fragments and components of the extracellular matrix. Arch Microbiol. 2009;191:153-61 pubmed publisher
    ..We have analyzed the adhesion properties of a collection of Lactobacillus casei strains from different origins, ranging from cheese isolates to commercial probiotics...
  35. Nadal I, Rico J, Perez Martinez G, Yebra M, Monedero V. Diacetyl and acetoin production from whey permeate using engineered Lactobacillus casei. J Ind Microbiol Biotechnol. 2009;36:1233-7 pubmed publisher
    The capability of Lactobacillus casei to produce the flavor-related compounds diacetyl and acetoin from whey permeate has been examined by a metabolic engineering approach. An L...
  36. Matsumoto S, Hara T, Nagaoka M, Mike A, Mitsuyama K, Sako T, et al. A component of polysaccharide peptidoglycan complex on Lactobacillus induced an improvement of murine model of inflammatory bowel disease and colitis-associated cancer. Immunology. 2009;128:e170-80 pubmed publisher
    ..cells and a cell wall-derived polysaccharide-peptidoglycan complex (PSPG) in a strain of lactobacillus [Lactobacillus casei Shirota (LcS)] inhibited IL-6 production in lipopolysaccharide (LPS)-stimulated lamina propria mononuclear ..
  37. Shida K, Kiyoshima Shibata J, Kaji R, Nagaoka M, Nanno M. Peptidoglycan from lactobacilli inhibits interleukin-12 production by macrophages induced by Lactobacillus casei through Toll-like receptor 2-dependent and independent mechanisms. Immunology. 2009;128:e858-69 pubmed publisher
    ..of lactobacilli and bacterial cell wall components on IL-12 production by macrophages that was induced by Lactobacillus casei, which has a rigid cell wall...
  38. Hacini Rachinel F, Nancey S, Boschetti G, Sardi F, Doucet Ladevèze R, Durand P, et al. CD4+ T cells and Lactobacillus casei control relapsing colitis mediated by CD8+ T cells. J Immunol. 2009;183:5477-86 pubmed publisher
    ..Oral administration of the probiotic strain Lactobacillus casei DN-114 001 alleviated colitis and increased the suppressive function of Foxp3(+)CD4(+) regulatory T cells ..
  39. Qiao X, Li G, Wang X, Li X, Liu M, Li Y. Recombinant porcine rotavirus VP4 and VP4-LTB expressed in Lactobacillus casei induced mucosal and systemic antibody responses in mice. BMC Microbiol. 2009;9:249 pubmed publisher
    ..Immune responses associated with protection are primarily mucosal in nature and induction of mucosal immunity is important for preventing porcine rotavirus infection...
  40. Herrero Fresno A, Martinez N, Sanchez Llana E, Diaz M, Fernandez M, Martín M, et al. Lactobacillus casei strains isolated from cheese reduce biogenic amine accumulation in an experimental model. Int J Food Microbiol. 2012;157:297-304 pubmed publisher
    ..All 17 isolates were identified by 16S rRNA sequencing as belonging to Lactobacillus casei. They were typed by plasmid S1-PFGE and genomic macrorestriction-PFGE analysis. Two strains (L...
  41. Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, et al. Phosphodiesterase inhibitors suppress Lactobacillus casei cell-wall-induced NF-?B and MAPK activations and cell proliferation through protein kinase A--or exchange protein activated by cAMP-dependent signal pathway. ScientificWorldJournal. 2012;2012:748572 pubmed publisher
    ..However, a high mortality rate results from underlying immunosuppressive conditions in patients with Lactobacillus casei bacteremia. Cyclic AMP (cAMP) is a small second messenger molecule that mediates signal transduction...
  42. Li H, Liu L, Zhang S, Cui W, Lv J. Identification of antifungal compounds produced by Lactobacillus casei AST18. Curr Microbiol. 2012;65:156-61 pubmed publisher
    b>Lactobacillus casei AST18 was screened as an antifungal lactic acid bacteria which we have reported before. In this research, the antifungal properties of cell-free culture filtrate (CCF) from L...
  43. Saxami G, Ypsilantis P, Sidira M, Simopoulos C, Kourkoutas Y, Galanis A. Distinct adhesion of probiotic strain Lactobacillus casei ATCC 393 to rat intestinal mucosa. Anaerobe. 2012;18:417-20 pubmed publisher
    ..In this study, the adhesion ability of Lactobacillus casei ATCC 393 to the gastrointestinal tract of Wistar rats was examined after single and daily administration of ..
  44. Toki S, Kagaya S, Shinohara M, Wakiguchi H, Matsumoto T, Takahata Y, et al. Lactobacillus rhamnosus GG and Lactobacillus casei suppress Escherichia coli-induced chemokine expression in intestinal epithelial cells. Int Arch Allergy Immunol. 2009;148:45-58 pubmed publisher
    ..We thus hypothesized that LAB influence the host immune system through the activation of IECs. To begin testing this hypothesis, chemokine expression in IECs exposed to intestinal bacteria was investigated...
  45. Fajardo Bernárdez P, Fuciños González C, Méndez Batán J, Pastrana Castro L, Pérez Guerra N. Performance and intestinal coliform counts in weaned piglets fed a probiotic culture (Lactobacillus casei subsp. casei CECT 4043) or an antibiotic. J Food Prot. 2008;71:1797-805 pubmed
    The production of biomass and antibacterial extracellular products by Lactobacillus casei subsp. casei CECT 4043 was followed in both batch and in realkalized fed-batch cultures...
  46. Martínez Gómez F, Santiago Rosales R, Ramón Bautista Garfias C. Effect of Lactobacillus casei Shirota strain intraperitoneal administration in CD1 mice on the establishment of Trichinella spiralis adult worms and on IgA anti-T. spiralis production. Vet Parasitol. 2009;162:171-5 pubmed publisher
    The effect of the intraperitoneal (ip) administration of Lactobacillus casei Shirota strain (LcS) in CD1 mice on the establishment of Trichinella spiralis adult worms (TSAW), and on the generation of intestinal IgA anti-T...
  47. Fujimoto J, Matsuki T, Sasamoto M, Tomii Y, Watanabe K. Identification and quantification of Lactobacillus casei strain Shirota in human feces with strain-specific primers derived from randomly amplified polymorphic DNA. Int J Food Microbiol. 2008;126:210-5 pubmed publisher
    b>Lactobacillus casei strain Shirota (LcS) has been used in the production of fermented milk products for many years and is one of the most intensively studied probiotics...
  48. Munoz Provencio D, Perez Martinez G, Monedero V. Characterization of a fibronectin-binding protein from Lactobacillus casei BL23. J Appl Microbiol. 2010;108:1050-9 pubmed publisher
    To characterize the functionality of the Lactobacillus casei BL23 fbpA gene encoding a putative fibronectin-binding protein.
  49. Landete J, Garcia Haro L, Blasco A, Manzanares P, Berbegal C, Monedero V, et al. Requirement of the Lactobacillus casei MaeKR two-component system for L-malic acid utilization via a malic enzyme pathway. Appl Environ Microbiol. 2010;76:84-95 pubmed publisher
    b>Lactobacillus casei can metabolize L-malic acid via malolactic enzyme (malolactic fermentation [MLF]) or malic enzyme (ME). Whereas utilization of L-malic acid via MLF does not support growth, the ME pathway enables L...
  50. Ge X, Yuan J, Qin H, Zhang W. Improvement of L-lactic acid production by osmotic-tolerant mutant of Lactobacillus casei at high temperature. Appl Microbiol Biotechnol. 2011;89:73-8 pubmed publisher
    L-Lactic acid production by Lactobacillus casei was used as a model to study the mechanism of substrate inhibition and the strategy for enhancing L-lactic acid production...
  51. Asahara T, Shimizu K, Takada T, Kado S, Yuki N, Morotomi M, et al. Protective effect of Lactobacillus casei strain Shirota against lethal infection with multi-drug resistant Salmonella enterica serovar Typhimurium DT104 in mice. J Appl Microbiol. 2011;110:163-73 pubmed publisher
    ..The anti-infectious activity of lactobacilli against multi-drug resistant Salmonella enterica serovar Typhimurium DT104 (DT104) was examined in a murine model of an opportunistic antibiotic-induced infection...
  52. Hwang J, Baek Y, Yang K, Yoo H, Cho C, Lee Y, et al. Lactobacillus casei extract induces apoptosis in gastric cancer by inhibiting NF-?B and mTOR-mediated signaling. Integr Cancer Ther. 2013;12:165-73 pubmed publisher
    b>Lactobacillus casei extract (LBX) has been reported to prevent gastric cancer, but the underlying mechanism remains unclear...
  53. Munoz Provencio D, Rodriguez Diaz J, Collado M, Langella P, Bermúdez Humarán L, Monedero V. Functional analysis of the Lactobacillus casei BL23 sortases. Appl Environ Microbiol. 2012;78:8684-93 pubmed publisher
    Sortases are a class of enzymes that anchor surface proteins to the cell wall of Gram-positive bacteria. Lactobacillus casei BL23 harbors four sortase genes, two belonging to class A (srtA1 and srtA2) and two belonging to class C (srtC1 ..
  54. Klewicka E, Cukrowska B, Libudzisz Z, Slizewska K, Motyl I. Changes in gut microbiota in children with atopic dermatitis administered the bacteria Lactobacillus casei DN--114001. Pol J Microbiol. 2011;60:329-33 pubmed
    ..months and suffering from atopic dermatitis before and after 3 month supplementation of their diet with Lactobacillus casei DN--114001 in a dose of 109 cells daily...
  55. Lee T, Kim Y, Lee K, Kim J, Lee I, Yang J, et al. Human papillomavirus type 16 E6-specific antitumor immunity is induced by oral administration of HPV16 E6-expressing Lactobacillus casei in C57BL/6 mice. Cancer Immunol Immunother. 2010;59:1727-37 pubmed publisher
    ..Here, we expressed the HPV16 E6 antigen on Lactobacillus casei (L. casei) and investigated E6-specific CMI following oral administration of the L. casei-PgsA-E6 to mice...
  56. Ai L, Chen C, Zhou F, Wang L, Zhang H, Chen W, et al. Complete genome sequence of the probiotic strain Lactobacillus casei BD-II. J Bacteriol. 2011;193:3160-1 pubmed publisher
    b>Lactobacillus casei BD-II, a patented probiotic strain (U.S. patent 7,270,994 B2), was isolated from homemade koumiss in China and has been implemented in the industrial production as starter cultures...
  57. Alcántara C, Zúñiga M. Proteomic and transcriptomic analysis of the response to bile stress of Lactobacillus casei BL23. Microbiology. 2012;158:1206-18 pubmed publisher
    b>Lactobacillus casei is a lactic acid bacterium commonly found in the gastrointestinal tract of animals, and some strains are used as probiotics...
  58. Villena J, Barbieri N, Salva S, Herrera M, Alvarez S. Enhanced immune response to pneumococcal infection in malnourished mice nasally treated with heat-killed Lactobacillus casei. Microbiol Immunol. 2009;53:636-46 pubmed publisher
    The present study analyzed whether nasal administration of viable and non-viable Lactobacillus casei CRL 431 to immunocompromised mice was capable of increasing resistance against Streptococcus pneumoniae...
  59. Chiba Y, Shida K, Nagata S, Wada M, Bian L, Wang C, et al. Well-controlled proinflammatory cytokine responses of Peyer's patch cells to probiotic Lactobacillus casei. Immunology. 2010;130:352-62 pubmed publisher
    ..In spleen cells, probiotic Lactobacillus casei induced interleukin (IL)-12 production by CD11b(+) cells more strongly than pathogenic Gram-positive and ..
  60. Bäuerl C, Perez Martinez G, Yan F, Polk D, Monedero V. Functional analysis of the p40 and p75 proteins from Lactobacillus casei BL23. J Mol Microbiol Biotechnol. 2010;19:231-41 pubmed publisher
    The genomes of Lactobacillus casei/paracasei and Lactobacillus rhamnosus strains carry two genes encoding homologues of p40 and p75 from L...
  61. De Preter V, Ghebretinsae A, Abrahantes J, Windey K, Rutgeerts P, Verbeke K. Impact of the synbiotic combination of Lactobacillus casei shirota and oligofructose-enriched inulin on the fecal volatile metabolite profile in healthy subjects. Mol Nutr Food Res. 2011;55:714-22 pubmed publisher
    ..However, the emergence of metabolite profiling strategies allows to evaluate the colonic metabolism from a top-down approach. In the present study, we evaluated the impact of a synbiotic combination on fecal metabolite profiles...
  62. Yadav H, Jain S, Sinha P. Oral administration of dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei delayed the progression of streptozotocin-induced diabetes in rats. J Dairy Res. 2008;75:189-95 pubmed publisher
    In this study, the effect of dahi containing probiotic Lactobacillus acidophilus NCDC14 and Lactobacillus casei NCDC19 (73 x 10(8) cfu/g) on progression of streptozotocin (STZ)-induced diabetes in rats (15 g/day/rat) for 28 days was ..
  63. Yasuda E, Serata M, Sako T. Suppressive effect on activation of macrophages by Lactobacillus casei strain Shirota genes determining the synthesis of cell wall-associated polysaccharides. Appl Environ Microbiol. 2008;74:4746-55 pubmed publisher
    ..We aimed to assess the function of polysaccharide moiety of the cell wall of Lactobacillus casei strain Shirota as a possible immune modulator which regulates cytokine production by macrophages...
  64. Douillard F, Ribbera A, Järvinen H, Kant R, Pietila T, Randazzo C, et al. Comparative genomic and functional analysis of Lactobacillus casei and Lactobacillus rhamnosus strains marketed as probiotics. Appl Environ Microbiol. 2013;79:1923-33 pubmed publisher
    ..rhamnosus GG and further highlights the differences between these and L. casei strains widely marketed as probiotics, in terms of genome content, mucus-binding and metabolic capacities, and host signaling capabilities...
  65. Schiffer C, Lalanne A, Cassard L, Mancardi D, Malbec O, Bruhns P, et al. A strain of Lactobacillus casei inhibits the effector phase of immune inflammation. J Immunol. 2011;187:2646-55 pubmed publisher
    ..The effects of one strain of Lactobacillus casei were investigated in vivo on IgE-induced passive systemic anaphylaxis and IgG-induced passive arthritis, ..
  66. Chiu Y, Hsieh Y, Liao K, Peng K. Preferential promotion of apoptosis of monocytes by Lactobacillus casei rhamnosus soluble factors. Clin Nutr. 2010;29:131-40 pubmed publisher
    ..Some probiotics inhibit monocytes' expansion, although mechanisms remain unknown. Supernatants of Lactobacillus strains were investigated for inducing apoptosis of monocytes...
  67. Guillemard E, Tanguy J, Flavigny A, de la Motte S, Schrezenmeir J. Effects of consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 on common respiratory and gastrointestinal infections in shift workers in a randomized controlled trial. J Am Coll Nutr. 2010;29:455-68 pubmed
    ..This study examined the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (verum) on the incidence of respiratory and gastrointestinal common infectious diseases (CIDs) ..
  68. de Leblanc A, Castillo N, Perdigon G. Anti-infective mechanisms induced by a probiotic Lactobacillus strain against Salmonella enterica serovar Typhimurium infection. Int J Food Microbiol. 2010;138:223-31 pubmed publisher
    ..The mechanism of the inhibition of cellular apoptosis was not involved...
  69. Matsuki T, Pedron T, Regnault B, Mulet C, Hara T, Sansonetti P. Epithelial cell proliferation arrest induced by lactate and acetate from Lactobacillus casei and Bifidobacterium breve. PLoS ONE. 2013;8:e63053 pubmed publisher
    ..These results demonstrate that the production of SCFAs, a characteristic of these symbiotic microorganisms, is potentially an essential regulatory effector of epithelial proliferation in the gut...
  70. Ferreira D, Darrieux M, Silva D, Leite L, Ferreira J, Ho P, et al. Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccines against a respiratory pneumococcal challenge in mice. Clin Vaccine Immunol. 2009;16:636-45 pubmed publisher
    ..responses induced by mucosal vaccines composed of both antigens as recombinant proteins or delivered by Lactobacillus casei were evaluated...
  71. Nowak A, Libudzisz Z. Ability of probiotic Lactobacillus casei DN 114001 to bind or/and metabolise heterocyclic aromatic amines in vitro. Eur J Nutr. 2009;48:419-27 pubmed publisher
    ..On the other hand, lactic acid bacteria existing in the colon and ingested with food including probiotics, may exert an anti-carcinogenic action, but the mechanism is still poorly understood...
  72. Wei C, Liu J, Hou X, Yu L, Lee J, Kim C. Immunogenicity and protective efficacy of orally or intranasally administered recombinant Lactobacillus casei expressing ETEC K99. Vaccine. 2010;28:4113-8 pubmed publisher
    ..The recombinant fusion proteins comprised of pgsA and fimbriae protein of ETEC K99 were stably expressed on Lactobacillus casei. Surface localization of the fusion protein was verified by immunoblotting, immunofluorescence microscopy ..
  73. Watanabe T, Nishio H, Tanigawa T, Yamagami H, Okazaki H, Watanabe K, et al. Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid. Am J Physiol Gastrointest Liver Physiol. 2009;297:G506-13 pubmed publisher
    ..The aim of this study was to investigate the probiotic effect of Lactobacillus casei strain Shirota (LcS) on indomethacin-induced small intestinal injury...
  74. Wu R, Zhang W, Sun T, Wu J, Yue X, Meng H, et al. Proteomic analysis of responses of a new probiotic bacterium Lactobacillus casei Zhang to low acid stress. Int J Food Microbiol. 2011;147:181-7 pubmed publisher
    ..Proteomics analysis of a new probiotic bacterium, Lactobacillus casei Zhang, was performed upon 30-min exposure to low acid stress (pH 2.5 vs. pH 6...
  75. Guillemard E, Tondu F, Lacoin F, Schrezenmeir J. Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr. 2010;103:58-68 pubmed publisher
    ..The present study examined the beneficial effect of a dairy product containing the probiotic strain Lactobacillus casei DN-114 001 (fermented product) on the resistance of free-living elderly to CID...
  76. Wu R, Wang W, Yu D, Zhang W, Li Y, Sun Z, et al. Proteomics analysis of Lactobacillus casei Zhang, a new probiotic bacterium isolated from traditional home-made koumiss in Inner Mongolia of China. Mol Cell Proteomics. 2009;8:2321-38 pubmed publisher
    b>Lactobacillus casei Zhang, isolated from traditional home-made koumiss in Inner Mongolia of China, was considered as a new probiotic bacterium by probiotic selection tests...
  77. Tanaka I, Tanaka M, Satoh A, Kurematsu A, Ishiwata A, Suzuki K, et al. Alteration of radioprotective effects of heat-killed Lactobacillus casei in X-irradiated C3H/He mouse related to blood level of proinflammatory cytokines by corticoids. J Radiat Res. 2010;51:81-6 pubmed
    ..We found that pre-administration of heat-killed Lactobacillus casei (HLC) to mice increases the level of interleukin (IL)-1 beta in circulation as well as the survival rate ..