lactobacillus acidophilus


Summary: A species of gram-positive, rod-shaped bacteria isolated from the intestinal tract of humans and animals, the human mouth, and vagina. This organism produces the fermented product, acidophilus milk.

Top Publications

  1. Singh V, Raheja G, Borthakur A, Kumar A, Gill R, Alakkam A, et al. Lactobacillus acidophilus upregulates intestinal NHE3 expression and function. Am J Physiol Gastrointest Liver Physiol. 2012;303:G1393-401 pubmed publisher
    ..We have previously demonstrated Lactobacillus acidophilus (LA) to stimulate Cl(-)/HCO3- exchange activity via an increase in the surface levels and expression of ..
  2. Urbanska A, Bhathena J, Martoni C, Prakash S. Estimation of the potential antitumor activity of microencapsulated Lactobacillus acidophilus yogurt formulation in the attenuation of tumorigenesis in Apc(Min/+) mice. Dig Dis Sci. 2009;54:264-73 pubmed publisher
    ..Daily oral administration of microencapsulated Lactobacillus acidophilus bacterial cells in the yogurt formulation mice resulted in significant suppression of colon tumor ..
  3. Mohamadzadeh M, Duong T, Sandwick S, Hoover T, Klaenhammer T. Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge. Proc Natl Acad Sci U S A. 2009;106:4331-6 pubmed publisher
    ..A vaccine strategy was established by using Lactobacillus acidophilus to deliver Bacillus anthracis protective antigen (PA) via specific dendritic cell-targeting peptides to ..
  4. Weiss G, Maaetoft Udsen K, Stifter S, Hertzog P, Goriely S, Thomsen A, et al. MyD88 drives the IFN-? response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7. J Immunol. 2012;189:2860-8 pubmed publisher
    ..demonstrated that this IFN response is not restricted to pathogens, as the Gram-positive bacterium Lactobacillus acidophilus, a natural inhabitant of the intestine, induces high levels of IFN-? in dendritic cells...
  5. Hole A, Rud I, Grimmer S, Sigl S, Narvhus J, Sahlstrøm S. Improved bioavailability of dietary phenolic acids in whole grain barley and oat groat following fermentation with probiotic Lactobacillus acidophilus , Lactobacillus johnsonii , and Lactobacillus reuteri. J Agric Food Chem. 2012;60:6369-75 pubmed publisher
    ..with three probiotic strains, Lactobacillus johnsonii LA1, Lactobacillus reuteri SD2112, and Lactobacillus acidophilus LA-5, with maximum increases from 2.55 to 69.91 ?g g(-1) DM and from 4.13 to 109...
  6. Kim Y, Mylonakis E. Caenorhabditis elegans immune conditioning with the probiotic bacterium Lactobacillus acidophilus strain NCFM enhances gram-positive immune responses. Infect Immun. 2012;80:2500-8 pubmed publisher
    ..elegans host responses. We found that the probiotic Gram-positive bacterium Lactobacillus acidophilus NCFM is not harmful to C. elegans and that L. acidophilus NCFM is unable to colonize the C...
  7. Fredslund F, Hachem M, Larsen R, S rensen P, Coutinho P, Lo Leggio L, et al. Crystal structure of ?-galactosidase from Lactobacillus acidophilus NCFM: insight into tetramer formation and substrate binding. J Mol Biol. 2011;412:466-80 pubmed publisher
    b>Lactobacillus acidophilus NCFM is a probiotic bacterium known for its beneficial effects on human health...
  8. Khazaie K, Zadeh M, Khan M, Bere P, Gounari F, Dennis K, et al. Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A. 2012;109:10462-7 pubmed publisher
    ..of the phosphoglycerol transferase gene that is responsible for lipoteichoic acid (LTA) biosynthesis in Lactobacillus acidophilus (NCK2025) rendered this bacterium able to significantly protect mice against induced colitis when ..
  9. Zhao J, Feng X, Zhang X, LE K. Effect of Porphyromonas gingivalis and Lactobacillus acidophilus on secretion of IL1B, IL6, and IL8 by gingival epithelial cells. Inflammation. 2012;35:1330-7 pubmed publisher
    ..This study explored the effect of Lactobacillus acidophilus on the specific expressions of the interleukins (ILs) IL1B, IL6, and IL8 induced by the pathogen...

More Information


  1. Kaushal D, Kansal V. Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum alleviates age-inflicted oxidative stress and improves expression of biomarkers of ageing in mice. Mol Biol Rep. 2012;39:1791-9 pubmed publisher
    ..lactis biovar diacetylactis NCDC-60) along with selected strain of Lactobacillus acidophilus LaVK2 (La-Dahi) or combined L. acidophilus and Bifidobacterium bifidum BbVK3 (LaBb-Dahi)...
  2. Bull M, Plummer S, Marchesi J, Mahenthiralingam E. The life history of Lactobacillus acidophilus as a probiotic: a tale of revisionary taxonomy, misidentification and commercial success. FEMS Microbiol Lett. 2013;349:77-87 pubmed publisher
    b>Lactobacillus acidophilus is a commercially significant bacterial probiotic, originally isolated from the human gastrointestinal tract and designated Bacillus acidophilus in 1900...
  3. Moeini H, Rahim R, Omar A, Shafee N, Yusoff K. Lactobacillus acidophilus as a live vehicle for oral immunization against chicken anemia virus. Appl Microbiol Biotechnol. 2011;90:77-88 pubmed publisher of Lactococcus lactis were used to display the VP1 protein of chicken anemia virus (CAV) on Lactobacillus acidophilus. One and two repeats of the cell wall binding domain of acmA gene were amplified from L...
  4. Medeiros J, Gonçalves T, Boyanova L, Pereira M, de Carvalho J, Pereira A, et al. Evaluation of Helicobacter pylori eradication by triple therapy plus Lactobacillus acidophilus compared to triple therapy alone. Eur J Clin Microbiol Infect Dis. 2011;30:555-9 pubmed publisher
    The purpose of this study was to evaluate the influence of adding Lactobacillus acidophilus to a triple regimen for Helicobacter pylori eradication in untreated patients with peptic ulcers or ulcer-scars...
  5. Ng E, Yeung M, Tong P. Effects of yogurt starter cultures on the survival of Lactobacillus acidophilus. Int J Food Microbiol. 2011;145:169-75 pubmed publisher
    Recognized to confer health benefits to consumers, probiotics such as Lactobacillus acidophilus are commonly incorporated into fermented dairy products worldwide; among which yogurt is a popular delivery vehicle...
  6. Buriti F, Castro I, Saad S. Viability of Lactobacillus acidophilus in synbiotic guava mousses and its survival under in vitro simulated gastrointestinal conditions. Int J Food Microbiol. 2010;137:121-9 pubmed publisher
    ..of refrigeration, freezing and substitution of milk fat by inulin and whey protein concentrate (WPC) on Lactobacillus acidophilus La-5 viability and resistance to gastric and enteric simulated conditions in synbiotic guava mousses ..
  7. Yazdi M, Soltan Dallal M, Hassan Z, Holakuyee M, Agha Amiri S, Abolhassani M, et al. Oral administration of Lactobacillus acidophilus induces IL-12 production in spleen cell culture of BALB/c mice bearing transplanted breast tumour. Br J Nutr. 2010;104:227-32 pubmed publisher
    ..In the present work, we studied the effects of oral administration of Lactobacillus acidophilus on the immune responses of BALB/c mice bearing transplanted breast tumour...
  8. Ehsandoost E, Gholami S, Nazemi M. Effect of denak (Oliveria decumbens Vent) on growth and survival of Lactobacillus acidophilus and Bifidobacterium bifidum for production of probiotic herbal milk and yoghurt. Pak J Biol Sci. 2013;16:2009-14 pubmed
    ..5, 1.0 and 1.5%) of Denak powder (Oliveria decumbens Vent) on viability of Lactobacillus acidophilus and Bifidobacterium bifidum in milk and yoghurt during 21 day refrigerated storage for production of ..
  9. Oh H, Lee J, Lim S, Kim M, Kim G, Kim J, et al. Molecular cloning and characterization of a bile salt hydrolase from Lactobacillus acidophilus PF01. J Microbiol Biotechnol. 2008;18:449-56 pubmed
    Phenotypic screening for bile salt hydrolase (BSH) activity was performed on Lactobacillus acidophilus PF01 isolated from piglet feces. A gene encoding BSH was identified and cloned from the genomic library of L. acidophilus PF01...
  10. Singh R, Damle S, Chawla A. Salivary mutans streptococci and lactobacilli modulations in young children on consumption of probiotic ice-cream containing Bifidobacterium lactis Bb12 and Lactobacillus acidophilus La5. Acta Odontol Scand. 2011;69:389-94 pubmed publisher
    ..In conclusion, probiotic ice-cream containing Bifidobacterium lactis Bb-12 ATCC27536 and Lactobacillus acidophilus La-5 can reduce the levels of certain caries-associated micro-organisms in saliva.
  11. Andersen J, Barrangou R, Abou Hachem M, Lahtinen S, Goh Y, Svensson B, et al. Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus. Proc Natl Acad Sci U S A. 2011;108:17785-90 pubmed publisher
    ..This study aimed to identify genetic loci in Lactobacillus acidophilus NCFM responsible for the transport and catabolism of GOS...
  12. Nakai H, Petersen B, Westphal Y, Dilokpimol A, Abou Hachem M, Duus J, et al. Rational engineering of Lactobacillus acidophilus NCFM maltose phosphorylase into either trehalose or kojibiose dual specificity phosphorylase. Protein Eng Des Sel. 2010;23:781-7 pubmed publisher
    b>Lactobacillus acidophilus NCFM maltose phosphorylase (LaMP) of the (alpha/alpha)(6)-barrel glycoside hydrolase family 65 (GH65) catalyses both phosphorolysis of maltose and formation of maltose by reverse phosphorolysis with beta-glucose ..
  13. Rerksuppaphol S, Rerksuppaphol L. Lactobacillus acidophilus and Bifidobacterium bifidum stored at ambient temperature are effective in the treatment of acute diarrhoea. Ann Trop Paediatr. 2010;30:299-304 pubmed publisher
    ..Probiotics such as Lactobacillus acidophilus and Bifidobacterium bifidum (Infloran(®)) are usually maintained at a storage temperature of 4°C which ..
  14. Martínez M, Prado Acosta M, Candurra N, Ruzal S. S-layer proteins of Lactobacillus acidophilus inhibits JUNV infection. Biochem Biophys Res Commun. 2012;422:590-5 pubmed publisher
    ..entry is enhanced in cells expressing DC-SIGN and for that reason surface-layer protein (S-layer) of Lactobacillus acidophilus ATCC 4365 was evaluated as a possible JUNV inhibitor...
  15. Albertini B, Vitali B, Passerini N, Cruciani F, Di Sabatino M, Rodriguez L, et al. Development of microparticulate systems for intestinal delivery of Lactobacillus acidophilus and Bifidobacterium lactis. Eur J Pharm Sci. 2010;40:359-66 pubmed publisher
    ..present study intestinal delivery systems resistant to gastric juice, loaded with the probiotic bacteria Lactobacillus acidophilus LA14 and Bifidobacterium lactis BI07, were produced by the polyelectrolyte complexation...
  16. Andersen J, Barrangou R, Hachem M, Lahtinen S, Goh Y, Svensson B, et al. Transcriptional analysis of prebiotic uptake and catabolism by Lactobacillus acidophilus NCFM. PLoS ONE. 2012;7:e44409 pubmed publisher
    ..Here differential transcriptomics and functional genomics were used to identify genes in Lactobacillus acidophilus NCFM involved in the uptake and catabolism of 11 potential prebiotic compounds consisting of ?- and ?-..
  17. Konstantinov S, Smidt H, de Vos W, Bruijns S, Singh S, Valence F, et al. S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions. Proc Natl Acad Sci U S A. 2008;105:19474-9 pubmed publisher
    ..Here, we examined the interactions of Lactobacillus acidophilus NCFM and its cell surface compounds with DCs. L...
  18. Khaleghi M, Kasra Kermanshahi R, Zarkesh Esfahani S. Effects of penicillin G on morphology and certain physiological parameters of Lactobacillus acidophilus ATCC 4356. J Microbiol Biotechnol. 2011;21:822-9 pubmed
    ..015, 0.03, and 0.06 mg/l) on the morphology and adhesion of Lactobacillus acidophilus ATCC 4356, including the colony morphotype, biofilm production, hydrophobicity, H?O? formation, S-layer ..
  19. Singh P, Chopra K, Kuhad A, Kaur I. Role of Lactobacillus acidophilus loaded floating beads in chronic fatigue syndrome: behavioral and biochemical evidences. Neurogastroenterol Motil. 2012;24:366-e170 pubmed publisher
    ..In the present study probable role of per-oral administration of free Lactobacillus acidophilus (LAB) and LAB loaded alginate beads in attenuation of the symptoms associated with chronic fatigue ..
  20. Torii S, Torii A, Itoh K, Urisu A, Terada A, Fujisawa T, et al. Effects of oral administration of Lactobacillus acidophilus L-92 on the symptoms and serum markers of atopic dermatitis in children. Int Arch Allergy Immunol. 2011;154:236-45 pubmed publisher
    Few studies have investigated the complementary effects of long-term oral administration of Lactobacillus acidophilus on traditional medical therapy in the treatment of patients with atopic dermatitis (AD).
  21. van Baarlen P, Troost F, van der Meer C, Hooiveld G, Boekschoten M, Brummer R, et al. Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4562-9 pubmed publisher
    ..In the mucosa of the proximal small intestine of healthy volunteers, probiotic strains from the species Lactobacillus acidophilus, L. casei, and L...
  22. Weiss G, Rasmussen S, Nielsen Fink L, Jarmer H, Nøhr Nielsen B, Frøkiaer H. Bifidobacterium bifidum actively changes the gene expression profile induced by Lactobacillus acidophilus in murine dendritic cells. PLoS ONE. 2010;5:e11065 pubmed publisher
    ..We have previously shown that Lactobacillus acidophilus induces a strong production of the pro-inflammatory and Th1 polarizing cytokine IL-12 in DC, whereas ..
  23. Lee J, Kim Y, Yun H, Kim J, Oh S, Kim S. Genetic and proteomic analysis of factors affecting serum cholesterol reduction by Lactobacillus acidophilus A4. Appl Environ Microbiol. 2010;76:4829-35 pubmed publisher
    ..Approximately 600 Lactobacillus acidophilus A4 mutants were created by random mutagenesis...
  24. Kajikawa A, Zhang L, Long J, Nordone S, Stoeker L, Lavoy A, et al. Construction and immunological evaluation of dual cell surface display of HIV-1 gag and Salmonella enterica serovar Typhimurium FliC in Lactobacillus acidophilus for vaccine delivery. Clin Vaccine Immunol. 2012;19:1374-81 pubmed publisher
    ..A recombinant Lactobacillus acidophilus strain expressing the HIV-1 Gag on the bacterial cell surface was established by fusion with the signal ..
  25. Zeinhom M, Tellez A, Delcenserie V, el Kholy A, El Shinawy S, Griffiths M. Yogurt containing bioactive molecules produced by Lactobacillus acidophilus La-5 exerts a protective effect against enterohemorrhagic Escherichia coli in mice. J Food Prot. 2012;75:1796-805 pubmed publisher
    An active fraction extracted from Lactobacillus acidophilus La5 cell-free spent medium (LAla-5AF) was incorporated in a dairy matrix and tested to assess its antivirulent effect against enterohemorrhagic Escherichia coli (EHEC)...
  26. Goh Y, Azcarate Peril M, O Flaherty S, Durmaz E, Valence F, Jardin J, et al. Development and application of a upp-based counterselective gene replacement system for the study of the S-layer protein SlpX of Lactobacillus acidophilus NCFM. Appl Environ Microbiol. 2009;75:3093-105 pubmed publisher
    In silico genome analysis of Lactobacillus acidophilus NCFM coupled with gene expression studies have identified putative genes and regulatory networks that are potentially important to this organism's survival, persistence, and ..
  27. Prado Acosta M, Ruzal S, Allievi M, Palomino M, Sanchez Rivas C. Synergistic effects of the Lactobacillus acidophilus surface layer and nisin on bacterial growth. Appl Environ Microbiol. 2010;76:974-7 pubmed publisher
    We have previously described a murein hydrolase activity for the surface layer (S-layer) of Lactobacillus acidophilus ATCC 4356...
  28. Pan Q, Zhu J, Liu L, Cong Y, Hu F, Li J, et al. Functional identification of a putative beta-galactosidase gene in the special lac gene cluster of Lactobacillus acidophilus. Curr Microbiol. 2010;60:172-8 pubmed publisher
    The putative beta-galactosidase gene (lacZ) of Lactobacillus acidophilus has a very low degree of homology to the Escherichia coli beta-galactosidase gene (lacZ) and locates in a special lac gene cluster which contains two beta-..
  29. Kim J, Kwon J, Ahn S, Lee S, Han Y, Choi Y, et al. Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial. Pediatr Allergy Immunol. 2010;21:e386-93 pubmed publisher
    ..lactis AD011, and Lactobacillus acidophilus AD031, or placebo, starting at 4-8 wks before delivery and continuing until 6 months after delivery...
  30. Medellin Peña M, Griffiths M. Effect of molecules secreted by Lactobacillus acidophilus strain La-5 on Escherichia coli O157:H7 colonization. Appl Environ Microbiol. 2009;75:1165-72 pubmed publisher
    The probiotic bacterium Lactobacillus acidophilus strain La-5 is a gut-colonizing microorganism that, when established, becomes an important part of the gastrointestinal (GI) tract microbiota...
  31. Tahmourespour A, Kermanshahi R. The effect of a probiotic strain (Lactobacillus acidophilus) on the plaque formation of oral Streptococci. Bosn J Basic Med Sci. 2011;11:37-40 pubmed
    ..of biofilm formation among mutans and non mutans oral streptococci and to determine the effect of Lactobacillus acidophilus DSM 20079 as a probiotic strain on the adhesion of selected streptococcal strains on the surfaces...
  32. Ringel Kulka T, Palsson O, Maier D, Carroll I, Galanko J, Leyer G, et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011;45:518-25 pubmed publisher
    ..Recent data suggest a role for the intestinal microbiota in the pathogenesis of functional bowel disorders (FBDs). Probiotic studies in FBDs generated inconsistent results suggesting a strain-specific and product-specific effect...
  33. Hayes M, Barrett E, Ross R, Fitzgerald G, Hill C, Stanton C. Evaluation of an antimicrobial ingredient prepared from a Lactobacillus acidophilus casein fermentate against Enterobacter sakazakii. J Food Prot. 2009;72:340-6 pubmed
    ..caseicin B), were identified following the fermentation of sodium caseinate with the proteolytic strain Lactobacillus acidophilus DPC 6026...
  34. Campana R, Federici S, Ciandrini E, Baffone W. Antagonistic activity of Lactobacillus acidophilus ATCC 4356 on the growth and adhesion/invasion characteristics of human Campylobacter jejuni. Curr Microbiol. 2012;64:371-8 pubmed publisher
    ..The observed inhibitory properties of L. acidophilus ATCC 4356 on growth ability and on cells adhesion/invasion of C. jejuni may offer potential use of this strain for the management of Campylobacter infections...
  35. Ejtahed H, Mohtadi Nia J, Homayouni Rad A, Niafar M, Asghari Jafarabadi M, Mofid V, et al. Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. J Dairy Sci. 2011;94:3288-94 pubmed publisher
    ..6 mmol/L were assigned to 2 groups. Participants consumed daily 300 g of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 or 300 g of conventional yogurt for 6 wk...
  36. Larsen N, Vogensen F, Gøbel R, Michaelsen K, Abu Al Soud W, Sørensen S, et al. Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07. FEMS Microbiol Ecol. 2011;75:482-96 pubmed publisher
    The effect of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 on the composition of the Lactobacillus group, Bifidobacterium and the total bacterial population in feces from young children with atopic ..
  37. Andreasen A, Larsen N, Pedersen Skovsgaard T, Berg R, Møller K, Svendsen K, et al. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr. 2010;104:1831-8 pubmed publisher
    ..Therefore, the effects of oral supplementation with the probiotic bacterium Lactobacillus acidophilus NCFM on insulin sensitivity and the inflammatory response were investigated in subjects with normal or ..
  38. Chitapanarux I, Chitapanarux T, Traisathit P, Kudumpee S, Tharavichitkul E, Lorvidhaya V. Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients. Radiat Oncol. 2010;5:31 pubmed publisher
    ..This study was performed to determine the ability of a probiotic containing live lactobacillus acidophilus plus bifidobacterium bifidum to reduce the incidence of radiation-induced diarrhea in locally advanced ..
  39. M ller M, Fredslund F, Majumder A, Nakai H, Poulsen J, Lo Leggio L, et al. Enzymology and structure of the GH13_31 glucan 1,6-?-glucosidase that confers isomaltooligosaccharide utilization in the probiotic Lactobacillus acidophilus NCFM. J Bacteriol. 2012;194:4249-59 pubmed publisher
    ..Genomes of probiotic lactobacilli from the acidophilus group, as represented by Lactobacillus acidophilus NCFM, encode ?-1,6 glucosidases of the family GH13_31 (glycoside hydrolase family 13 subfamily 31) that ..
  40. Fung W, Woo Y, Liong M. Optimization of growth of Lactobacillus acidophilus FTCC 0291 and evaluation of growth characteristics in soy whey medium: a response surface methodology approach. J Agric Food Chem. 2008;56:7910-8 pubmed publisher
    Four strains of probiotics were evaluated for their alpha-galactosidase activity. Lactobacillus acidophilus FTCC 0291 displayed the highest specific alpha-galactosidase activity and was thus selected to be optimized in soy whey medium ..
  41. Walencka E, Rozalska S, Sadowska B, Rozalska B. The influence of Lactobacillus acidophilus-derived surfactants on staphylococcal adhesion and biofilm formation. Folia Microbiol (Praha). 2008;53:61-6 pubmed publisher
    The ability of surfactants obtained from three Lactobacillus acidophilus strains to inhibit Staphylococcus aureus and S. epidermidis biofilms was evaluated...
  42. Schmidt E, Claesson M, Jensen S, Ravn P, Kristensen N. Antigen-presenting cells exposed to Lactobacillus acidophilus NCFM, Bifidobacterium bifidum BI-98, and BI-504 reduce regulatory T cell activity. Inflamm Bowel Dis. 2010;16:390-400 pubmed publisher
    The effect in vitro of six different probiotic strains including Lactobacillus acidophilus NCFM, Lactobacillus salivarius Ls-33, Lactobacillus paracasei subsp...
  43. Yadav H, Jain S, Sinha P. Oral administration of dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei delayed the progression of streptozotocin-induced diabetes in rats. J Dairy Res. 2008;75:189-95 pubmed publisher
    In this study, the effect of dahi containing probiotic Lactobacillus acidophilus NCDC14 and Lactobacillus casei NCDC19 (73 x 10(8) cfu/g) on progression of streptozotocin (STZ)-induced diabetes in rats (15 g/day/rat) for 28 days was ..
  44. Azevedo M, Zhang W, Wen K, Gonzalez A, Saif L, Yousef A, et al. Lactobacillus acidophilus and Lactobacillus reuteri modulate cytokine responses in gnotobiotic pigs infected with human rotavirus. Benef Microbes. 2012;3:33-42 pubmed publisher
    ..Our goal was to delineate the influence of combining two probiotic strains of Lactobacillus acidophilus and Lactobacillus reuteri on the development of cytokine responses in neonatal gnotobiotic pigs infected ..
  45. Foye O, Huang I, Chiou C, Walker W, Shi H. Early administration of probiotic Lactobacillus acidophilus and/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling. FEMS Immunol Med Microbiol. 2012;65:467-80 pubmed publisher
    ..A murine model to parallel infantile enteric disease was used to determine the effects of probiotic, Lactobacillus acidophilus (La), prebiotic, inulin, or both (synbiotic, syn) on pathogen-induced inflammatory responses, NF-?B, and ..
  46. Silva M, Dias G, Ferreira C, Franceschini S, Costa N. Growth of preschool children was improved when fed an iron-fortified fermented milk beverage supplemented with Lactobacillus acidophilus. Nutr Res. 2008;28:226-32 pubmed publisher
    ..milk beverage was fortified with iron amino acid chelate (3 mg iron per 80 mL) and supplemented with Lactobacillus acidophilus (test) or not (control)...
  47. Oh S, Roh H, Ko H, Kim S, Kim K, Lee S, et al. Complete genome sequencing of Lactobacillus acidophilus 30SC, isolated from swine intestine. J Bacteriol. 2011;193:2882-3 pubmed publisher
    b>Lactobacillus acidophilus 30SC has been isolated from swine intestines and considered a probiotic strain for dairy products because of its ability to assimilate cholesterol and produce bacteriocins...
  48. Buck B, Azcarate Peril M, Klaenhammer T. Role of autoinducer-2 on the adhesion ability of Lactobacillus acidophilus. J Appl Microbiol. 2009;107:269-79 pubmed publisher
    ..The aim of this study was to investigate whether or not the quorum-sensing signalling molecule, autoinducer (AI)-2, was produced by Lactobacillus acidophilus and affected adherence to intestinal epithelial cells.
  49. Pfeiler E, Klaenhammer T. Role of transporter proteins in bile tolerance of Lactobacillus acidophilus. Appl Environ Microbiol. 2009;75:6013-6 pubmed publisher
    b>Lactobacillus acidophilus NCFM derivatives containing deletion mutations in the transporter genes LBA0552, LBA1429, LBA1446, and LBA1679 exhibited increased sensitivity to bile...
  50. Li P, Yin Y, Yu Q, Yang Q. Lactobacillus acidophilus S-layer protein-mediated inhibition of Salmonella-induced apoptosis in Caco-2 cells. Biochem Biophys Res Commun. 2011;409:142-7 pubmed publisher
    ..In addition, Salmonella-induced apoptotic cell damage was modified by S-layer proteins through the ERK1/2 signaling pathway. This mechanism may represent a novel approach for antagonizing Salmonella infection...
  51. Mohamadzadeh M, Pfeiler E, Brown J, Zadeh M, Gramarossa M, Managlia E, et al. Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4623-30 pubmed publisher
    ..the phosphoglycerol transferase gene that plays a key role in lipoteichoic acid (LTA) biosynthesis in Lactobacillus acidophilus NCFM (NCK56) was deleted. The data show that the L...
  52. Lahtinen S, Forssten S, Aakko J, Granlund L, Rautonen N, Salminen S, et al. Probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM® modifies subpopulations of fecal lactobacilli and Clostridium difficile in the elderly. Age (Dordr). 2012;34:133-43 pubmed publisher
    ..trial, we assessed the effects of a probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM on the intestinal microbiota and fecal immune markers of 31 elderly volunteers and compared these ..
  53. Cheon S, Lee K, Kim K, Park J, Park S, Kim C, et al. Heat-killed Lactobacillus acidophilus La205 enhances NK cell cytotoxicity through increased granule exocytosis. Immunol Lett. 2011;136:171-6 pubmed publisher
    ..In this study, we investigated the effect of heat-killed Lactobacillus acidophilus La205 (La205) on NK cytolytic activity...
  54. Gao X, Mubasher M, Fang C, Reifer C, Miller L. Dose-response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea prophylaxis in adult patients. Am J Gastroenterol. 2010;105:1636-41 pubmed publisher
    ..Standard therapies for antibiotic-associated diarrhea (AAD) and Clostridium difficile-associated diarrhea (CDAD) have limited efficacy. Probiotic prophylaxis is a promising alternative for reduction of AAD and CDAD incidence...
  55. Nakai H, Baumann M, Petersen B, Westphal Y, Schols H, Dilokpimol A, et al. The maltodextrin transport system and metabolism in Lactobacillus acidophilus NCFM and production of novel alpha-glucosides through reverse phosphorolysis by maltose phosphorylase. FEBS J. 2009;276:7353-65 pubmed publisher
    A gene cluster involved in maltodextrin transport and metabolism was identified in the genome of Lactobacillus acidophilus NCFM, which encoded a maltodextrin-binding protein, three maltodextrin ATP-binding cassette transporters and five ..
  56. Nakai H, Dilokpimol A, Abou Hachem M, Svensson B. Efficient one-pot enzymatic synthesis of alpha-(1-->4)-glucosidic disaccharides through a coupled reaction catalysed by Lactobacillus acidophilus NCFM maltose phosphorylase. Carbohydr Res. 2010;345:1061-4 pubmed publisher
    b>Lactobacillus acidophilus NCFM maltose phosphorylase (LaMalP) of glycoside hydrolase family 65 catalysed enzymatic synthesis of alpha-(1-->4)-glucosidic disaccharides from maltose and five monosaccharides in a coupled phosphorolysis/..
  57. Sun J, Zhou T, Le G, Shi Y. Association of Lactobacillus acidophilus with mice Peyer's patches. Nutrition. 2010;26:1008-13 pubmed publisher
    To clarify the adhesion mechanism of Lactobacillus acidophilus to Peyer's patches.
  58. Lin C, Tsai H, Lin P, Tsen H, Tsai C. Lactobacillus acidophilus LAP5 able to inhibit the Salmonella choleraesuis invasion to the human Caco-2 epithelial cell. Anaerobe. 2008;14:251-5 pubmed publisher
    ..Previously, we found a strain of Lactobacillus acidophilus isolated from swine, i.e. strain LAP5, was with antagonistic effect against Salmonella typhimurium...
  59. O Flaherty S, Klaenhammer T. Functional and phenotypic characterization of a protein from Lactobacillus acidophilus involved in cell morphology, stress tolerance and adherence to intestinal cells. Microbiology. 2010;156:3360-7 pubmed publisher
    ..These results indicate a role for LBA649 in stress tolerance, cell wall division and adherence to Caco-2 cells...
  60. Sunada Y, Nakamura S, Kamei C. Effect of Lactobacillus acidophilus strain L-55 on the development of atopic dermatitis-like skin lesions in NC/Nga mice. Int Immunopharmacol. 2008;8:1761-6 pubmed publisher
    In this study, we examined whether Lactobacillus acidophilus strain L-55 (strain L-55) suppresses the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of 2,4,6-trinitrochlorobenzene (TNCB) in ..
  61. Chen C, Chiu C, Lin T, Shi H, Walker W. Effect of probiotics Lactobacillus acidophilus on Citrobacter rodentium colitis: the role of dendritic cells. Pediatr Res. 2009;65:169-75 pubmed publisher
    ..We preinoculated the mice early in life with the probiotic bacteria Lactobacillus acidophilus NCFM (La) at age 2 wk...
  62. Kim Y, Whang J, Whang K, Oh S, Kim S. Characterization of the cholesterol-reducing activity in a cell-free supernatant of Lactobacillus acidophilus ATCC 43121. Biosci Biotechnol Biochem. 2008;72:1483-90 pubmed
    This study characterizes the factors responsible for the cholesterol reduction by Lactobacillus acidophilus ATCC 43121...
  63. Zeuthen L, Fink L, Metzdorff S, Kristensen M, Licht T, Nellemann C, et al. Lactobacillus acidophilus induces a slow but more sustained chemokine and cytokine response in naïve foetal enterocytes compared to commensal Escherichia coli. BMC Immunol. 2010;11:2 pubmed publisher
    ..Facultative anaerobic bacteria are the first to colonise the infant gut, and the impact of these bacteria on intestinal epithelial cells (IEC) may be determinant for how the immune system subsequently tolerates gut bacteria...
  64. Chen C, Lin W, Kong M, Shi H, Walker W, Lin C, et al. Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue. Br J Nutr. 2012;107:1623-34 pubmed publisher
    ..We orally pre-inoculated mice with probiotics Lactobacillus acidophilus NCFM (La) for 14 d...
  65. Björklund M, Ouwehand A, Forssten S, Nikkilä J, Tiihonen K, Rautonen N, et al. Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol. Age (Dordr). 2012;34:987-99 pubmed publisher
    ..The synbiotic product consisted of the probiotic Lactobacillus acidophilus NCFM and the prebiotic lactitol and was ingested twice a day, with a total daily dose of 10 g lactitol ..
  66. Majumder A, Sultan A, Jersie Christensen R, Ejby M, Schmidt B, Lahtinen S, et al. Proteome reference map of Lactobacillus acidophilus NCFM and quantitative proteomics towards understanding the prebiotic action of lactitol. Proteomics. 2011;11:3470-81 pubmed publisher
    b>Lactobacillus acidophilus NCFM is a probiotic bacterium adapted to survive in the gastrointestinal tract and with potential health benefits to the host...
  67. Pescuma M, Hébert E, Dalgalarrondo M, Haertle T, Mozzi F, Chobert J, et al. Effect of exopolysaccharides on the hydrolysis of beta-lactoglobulin by Lactobacillus acidophilus CRL 636 in an in vitro gastric/pancreatic system. J Agric Food Chem. 2009;57:5571-7 pubmed publisher
    An analysis of the peptides generated by hydrolysis of BLG by nonproliferating cells of the strain Lactobacillus acidophilus CRL 636 was carried out...
  68. Lightfoot Y, Yang T, Sahay B, Mohamadzadeh M. Targeting aberrant colon cancer-specific DNA methylation with lipoteichoic acid-deficient Lactobacillus acidophilus. Gut Microbes. 2013;4:84-8 pubmed publisher
    ..Previously, we demonstrated that a lipoteichoic acid (LTA)-deficient Lactobacillus acidophilus strain, NCK2025, ameliorated inflammation-induced colitis, significantly reduced the number of polyps in ..
  69. Johnson B, Selle K, O Flaherty S, Goh Y, Klaenhammer T. Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM. Microbiology. 2013;159:2269-82 pubmed publisher
    ..The S-layer-forming bacterium Lactobacillus acidophilus NCFM expresses three major Slps: SlpA (46 kDa), SlpB (47 kDa) and SlpX (51 kDa)...
  70. Yanagihara S, Hirota T, Yamamoto N. Transcriptional response of Lactobacillus acidophilus L-92 after attachment to epithelial Caco-2 cells. J Biosci Bioeng. 2012;114:582-5 pubmed publisher
    Transcriptome analysis showed that Lactobacillus acidophilus L-92 cells having anti-allergy effects on human up-regulated 41 genes involved permease, ABC transporter, proteinase and transcriptional regulator after attached to epithelial ..
  71. Majumder A, Cai L, Ejby M, Schmidt B, Lahtinen S, Jacobsen S, et al. Two-dimensional gel-based alkaline proteome of the probiotic bacterium Lactobacillus acidophilus NCFM. Proteomics. 2012;12:1006-14 pubmed publisher
    b>Lactobacillus acidophilus NCFM (NCFM) is a well-documented probiotic bacterium isolated from human gut. Detailed 2D gel-based NCFM proteomics addressed the so-called alkaline range, i.e., pH 6-11...
  72. Yang Y, Chuang C, Yang H, Lu C, Sheu B. Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NF?B pathways. BMC Microbiol. 2012;12:38 pubmed publisher
    ..This study examines if probiotics can improve H. pylori-induced gastric inflammation by inactivating the Smad7 and NF?B pathways...
  73. Arora T, Anastasovska J, Gibson G, Tuohy K, Sharma R, Bell J, et al. Effect of Lactobacillus acidophilus NCDC 13 supplementation on the progression of obesity in diet-induced obese mice. Br J Nutr. 2012;108:1382-9 pubmed publisher
    ..In the present study, Lactobacillus acidophilus NCDC 13 was used to evaluate its anti-obesity potential in diet-induced obese (C57BL/6) mice...
  74. Savard P, Lamarche B, Paradis M, Thiboutot H, Laurin E, Roy D. Impact of Bifidobacterium animalis subsp. lactis BB-12 and, Lactobacillus acidophilus LA-5-containing yoghurt, on fecal bacterial counts of healthy adults. Int J Food Microbiol. 2011;149:50-7 pubmed publisher
    ..lactis (BB-12) and Lactobacillus acidophilus (LA-5) on fecal bacterial counts of healthy adults...
  75. Kurtmann L, Carlsen C, Skibsted L, Risbo J. Water activity-temperature state diagrams of freeze-dried Lactobacillus acidophilus (La-5): influence of physical state on bacterial survival during storage. Biotechnol Prog. 2009;25:265-70 pubmed publisher
    Water activity-temperature state diagrams for Lactobacillus acidophilus freeze-dried in a sucrose or a lactose matrix were established based on determination of stabilized glass transition temperatures by differential scanning ..
  76. Patrignani F, Burns P, Serrazanetti D, Vinderola G, Reinheimer J, Lanciotti R, et al. Suitability of high pressure-homogenized milk for the production of probiotic fermented milk containing Lactobacillus paracasei and Lactobacillus acidophilus. J Dairy Res. 2009;76:74-82 pubmed publisher
    ..All the samples received high sensory analysis scores for each descriptor considered. HPH treatment of milk can potentially diversify the market for probiotic fermented milks, especially in terms of texture parameters...
  77. Goto H, Sagitani A, Ashida N, Kato S, Hirota T, Shinoda T, et al. Anti-influenza virus effects of both live and non-live Lactobacillus acidophilus L-92 accompanied by the activation of innate immunity. Br J Nutr. 2013;110:1810-8 pubmed publisher
    The antiviral effects of both a live and non-live Lactobacillus acidophilus strain L-92 (L-92) were investigated by oral administration (10 mg/mouse per d) daily for 21 d in a mouse model infected intranasally with influenza virus (H1N1)...
  78. Ashraf R, Shah N. Selective and differential enumerations of Lactobacillus delbrueckii subsp. bulgaricus, Streptococcus thermophilus, Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium spp. in yoghurt--a review. Int J Food Microbiol. 2011;149:194-208 pubmed publisher
    ..and Lb. casei. Bifidobacterium could be enumerated on MRS agar supplemented with nalidixic acid, paromomycin, neomycin sulphate and lithium chloride (MRS-NPNL) under anaerobic incubation at 37°C for 72h...
  79. Kajikawa A, Nordone S, Zhang L, Stoeker L, LaVoy A, Klaenhammer T, et al. Dissimilar properties of two recombinant Lactobacillus acidophilus strains displaying Salmonella FliC with different anchoring motifs. Appl Environ Microbiol. 2011;77:6587-96 pubmed publisher
    ..In this study, two recombinant Lactobacillus acidophilus derivatives displaying Salmonella flagellin (FliC) were constructed using different anchor motifs...