neisseria

Summary

Summary: A genus of gram-negative, aerobic, coccoid bacteria whose organisms are part of the normal flora of the oropharynx, nasopharynx, and genitourinary tract. Some species are primary pathogens for humans.

Top Publications

  1. Vandamme P, Holmes B, Bercovier H, Coenye T. Classification of Centers for Disease Control Group Eugonic Fermenter (EF)-4a and EF-4b as Neisseria animaloris sp. nov. and Neisseria zoodegmatis sp. nov., respectively. Int J Syst Evol Microbiol. 2006;56:1801-5 pubmed
    ..Comparative 16S rRNA gene sequence analysis confirmed that group EF-4a and EF-4b belong to the genus Neisseria with Neisseria canis and Neisseria dentiae as the nearest phylogenetic neighbours...
  2. Cortes J, Simeon T, Remaud Simeon M, Tran V. Geometric algorithms for the conformational analysis of long protein loops. J Comput Chem. 2004;25:956-67 pubmed
    ..results demonstrate the efficacy of the approach for studying the mobility of loop 7 in amylosucrase from Neisseria polysaccharea...
  3. Büttcher V, Quanz M, Willmitzer L. Molecular cloning, functional expression and purification of a glucan branching enzyme from Neisseria denitrificans(1). Biochim Biophys Acta. 1999;1432:406-12 pubmed
    ..sequence containing the complete structural information for a glucan branching enzyme was isolated from a Neisseria denitrificans genomic library...
  4. Marri P, Paniscus M, Weyand N, Rendón M, Calton C, Hernández D, et al. Genome sequencing reveals widespread virulence gene exchange among human Neisseria species. PLoS ONE. 2010;5:e11835 pubmed publisher
    ..The genus Neisseria, containing both commensal and pathogenic species, provides an excellent opportunity to study these issues...
  5. Bennett J, Jolley K, Earle S, Corton C, Bentley S, Parkhill J, et al. A genomic approach to bacterial taxonomy: an examination and proposed reclassification of species within the genus Neisseria. Microbiology. 2012;158:1570-80 pubmed publisher
    In common with other bacterial taxa, members of the genus Neisseria are classified using a range of phenotypic and biochemical approaches, which are not entirely satisfactory in assigning isolates to species groups...
  6. Ayala B, Vasquez B, Clary S, Tainer J, Rodland K, So M. The pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of Lamp1 accessible to Neisseria IgA1 protease. Cell Microbiol. 2001;3:265-75 pubmed
    ..We demonstrate that Neisseria pili induce a transient increase in the levels of cytosolic free Ca2+ in A431 human epithelial cells, as ..
  7. Faridmoayer A, Fentabil M, Haurat M, Yi W, Woodward R, Wang P, et al. Extreme substrate promiscuity of the Neisseria oligosaccharyl transferase involved in protein O-glycosylation. J Biol Chem. 2008;283:34596-604 pubmed publisher
    b>Neisseria meningitidis PglL belongs to a novel family of bacterial oligosaccharyltransferases (OTases) responsible for O-glycosylation of type IV pilins...
  8. Saunders N, Snyder L. The minimal mobile element. Microbiology. 2002;148:3756-60 pubmed
  9. Furuya R, Onoye Y, Kanayama A, Saika T, Iyoda T, Tatewaki M, et al. Antimicrobial resistance in clinical isolates of Neisseria subflava from the oral cavities of a Japanese population. J Infect Chemother. 2007;13:302-4 pubmed
    A recent study indicated that Neisseria subflava, one of the commensal Neisseria species, may play an important role in the emergence of Neisseria gonorrhoeae strains with chromosomally mediated resistance to penicillin or cephalosporin ..

More Information

Publications100

  1. Lansac N, Picard F, Menard C, Boissinot M, Ouellette M, Roy P, et al. Novel genus-specific PCR-based assays for rapid identification of Neisseria species and Neisseria meningitidis. Eur J Clin Microbiol Infect Dis. 2000;19:443-51 pubmed
    ..presents the development of polymerase chain reaction (PCR)-based tests for the identification and detection of Neisseria species and Neisseria meningitidis...
  2. Allison K, Clarridge J. Long-term respiratory tract infection with canine-associated Pasteurella dagmatis and Neisseria canis in a patient with chronic bronchiectasis. J Clin Microbiol. 2005;43:4272-4 pubmed
    Pasteurella dagmatis and Neisseria canis were repeatedly isolated from the sputum of a poodle-owning patient with chronic bronchiectasis...
  3. Kawai M, Nakao K, Uchiyama I, Kobayashi I. How genomes rearrange: genome comparison within bacteria Neisseria suggests roles for mobile elements in formation of complex genome polymorphisms. Gene. 2006;383:52-63 pubmed
    ..approach to more complex genome polymorphisms that were observed when four genome sequences of bacterial genus Neisseria were compared...
  4. Muto M, Hitomi Y, Ohtsu A, Shimada H, Kashiwase Y, Sasaki H, et al. Acetaldehyde production by non-pathogenic Neisseria in human oral microflora: implications for carcinogenesis in upper aerodigestive tract. Int J Cancer. 2000;88:342-50 pubmed
    ..Here we demonstrate that, among the bacterial species identified from the human oral cavity, genus Neisseria had extremely high ADH activity and produced significant amounts of acetaldehyde when cultured with medium ..
  5. Smith N, Holmes E, Donovan G, Carpenter G, Spratt B. Networks and groups within the genus Neisseria: analysis of argF, recA, rho, and 16S rRNA sequences from human Neisseria species. Mol Biol Evol. 1999;16:773-83 pubmed publisher
    ..and rho genes, as well as part of the small-subunit (16S) rRNA gene, from about 50 isolates of human commensal Neisseria species and the pathogenic N. meningitidis and N. gonorrhoeae...
  6. Alber D, Oberkötter M, Suerbaum S, Claus H, Frosch M, Vogel U. Genetic diversity of Neisseria lactamica strains from epidemiologically defined carriers. J Clin Microbiol. 2001;39:1710-5 pubmed
    We assessed the genetic diversity of 26 Neisseria lactamica strains from epidemiologically related sources, i.e...
  7. John C, Liu M, Jarvis G. Profiles of structural heterogeneity in native lipooligosaccharides of Neisseria and cytokine induction. J Lipid Res. 2009;50:424-38 pubmed publisher
    Fine differences in the phosphorylation and acylation of lipooligosaccharide (LOS) from Neisseria species are thought to profoundly influence the virulence of the organisms and the innate immune responses of the host, such as signaling ..
  8. Saez Nieto J, Lujan R, Martinez Suarez J, Berron S, Vazquez J, Vinas M, et al. Neisseria lactamica and Neisseria polysaccharea as possible sources of meningococcal beta-lactam resistance by genetic transformation. Antimicrob Agents Chemother. 1990;34:2269-72 pubmed
    We studied the susceptibilities of relatively penicillin G-resistant and -susceptible strains of Neisseria meningitidis, as well as Neisseria lactamica and Neisseria polysaccharea, to penicillin, ampicillin, and several cephalosporins...
  9. Davidsen T, Bjørås M, Seeberg E, Tønjum T. Antimutator role of DNA glycosylase MutY in pathogenic Neisseria species. J Bacteriol. 2005;187:2801-9 pubmed
    Genome alterations due to horizontal gene transfer and stress constantly generate strain on the gene pool of Neisseria meningitidis, the causative agent of meningococcal (MC) disease...
  10. Wolfgang W, Carpenter A, Cole J, Gronow S, Habura A, Jose S, et al. Neisseria wadsworthii sp. nov. and Neisseria shayeganii sp. nov., isolated from clinical specimens. Int J Syst Evol Microbiol. 2011;61:91-8 pubmed publisher
    An analysis of 16S rRNA gene sequences from archived clinical reference specimens has identified two novel Neisseria species. For each species, two strains from independent sources were identified...
  11. Snyder L, McGowan S, Rogers M, Duro E, O Farrell E, Saunders N. The repertoire of minimal mobile elements in the Neisseria species and evidence that these are involved in horizontal gene transfer in other bacteria. Mol Biol Evol. 2007;24:2802-15 pubmed
    In the Neisseria spp...
  12. Noinaj N, Buchanan S, Cornelissen C. The transferrin-iron import system from pathogenic Neisseria species. Mol Microbiol. 2012;86:246-57 pubmed publisher
    Two pathogenic species within the genus Neisseria cause the diseases gonorrhoea and meningitis. While vaccines are available to protect against four N...
  13. Källström H, Liszewski M, Atkinson J, Jonsson A. Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Mol Microbiol. 1997;25:639-47 pubmed
    Pili of Neisseria gonorrhoeae and Neisseria meningitidis mediate binding of the bacteria to human cell-surface receptors...
  14. Hanage W, Fraser C, Spratt B. Fuzzy species among recombinogenic bacteria. BMC Biol. 2005;3:6 pubmed
    ..We have used concatenated sequences of seven house-keeping loci from 770 strains of 11 named Neisseria species, and phylogenetic trees, to investigate whether genotypic clusters can be resolved among these ..
  15. Skov L, Mirza O, Sprogøe D, Dar I, Remaud Simeon M, Albenne C, et al. Oligosaccharide and sucrose complexes of amylosucrase. Structural implications for the polymerase activity. J Biol Chem. 2002;277:47741-7 pubmed
    ..The polymer binding introduces structural changes that allow sucrose to migrate from its binding site into the active site and displace the polymer. ..
  16. Feil E, Zhou J, Maynard Smith J, Spratt B. A comparison of the nucleotide sequences of the adk and recA genes of pathogenic and commensal Neisseria species: evidence for extensive interspecies recombination within adk. J Mol Evol. 1996;43:631-40 pubmed
    ..sequences of the adenylate kinase gene (adk) and the RecA gene (recA) were determined from the same isolates of Neisseria gonorrhoeae, N. meningitidis, N. lactamica, N. polysaccharea, N. cinerea, N. mucosa, N. pharyngis var. flava, N...
  17. Noinaj N, Easley N, Oke M, Mizuno N, Gumbart J, Boura E, et al. Structural basis for iron piracy by pathogenic Neisseria. Nature. 2012;483:53-8 pubmed publisher
    b>Neisseria are obligate human pathogens causing bacterial meningitis, septicaemia and gonorrhoea. Neisseria require iron for survival and can extract it directly from human transferrin for transport across the outer membrane...
  18. Knapp J, Johnson S, Zenilman J, Roberts M, Morse S. High-level tetracycline resistance resulting from TetM in strains of Neisseria spp., Kingella denitrificans, and Eikenella corrodens. Antimicrob Agents Chemother. 1988;32:765-7 pubmed
    Similar to Neisseria gonorrhoeae, tetracycline-resistant isolates of N. meningitidis, Kingella denitrificans, and Eikenella corrodens contained 25.2-megadalton plasmids carrying the TetM determinant. In contrast, tetracycline-resistant N...
  19. Snyder L, Shafer W, Saunders N. Divergence and transcriptional analysis of the division cell wall (dcw) gene cluster in Neisseria spp. Mol Microbiol. 2003;47:431-42 pubmed
    Three of the 18 open reading frames in the division and cell wall synthesis cluster of the pathogenic Neisseria spp. are not present in the clusters of other bacterial species...
  20. Aho E, Urwin R, Batcheller A, Holmgren A, Havig K, Kulakoski A, et al. Neisserial pilin genes display extensive interspecies diversity. FEMS Microbiol Lett. 2005;249:327-34 pubmed
    All Neisseria live in association with host cells, however, little is known about the genetic potential of nonpathogenic Neisseria species to express attachment factors such as pili...
  21. Lau P, Forghani F, Labb D, Bergeron H, Brousseau R, H ltke H. The NlaIV restriction and modification genes of Neisseria lactamica are flanked by leucine biosynthesis genes. Mol Gen Genet. 1994;243:24-31 pubmed
    The genes encoding the Neisseria lactamica restriction endonuclease IV (R.NlaIV) and its cognate DNA methyltransferase (M...
  22. Valenza G, Ruoff C, Vogel U, Frosch M, Abele Horn M. Microbiological evaluation of the new VITEK 2 Neisseria-Haemophilus identification card. J Clin Microbiol. 2007;45:3493-7 pubmed
    VITEK 2 is an automated identification system for diverse bacterial and fungal species. A new card (the Neisseria-Haemophilus [NH] card) for the identification of Neisseria spp., Haemophilus spp...
  23. Snyder L, Saunders N. The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'. BMC Genomics. 2006;7:128 pubmed
    b>Neisseria meningitidis causes the life-threatening diseases meningococcal meningitis and meningococcal septicemia. Neisseria gonorrhoeae is closely related to the meningococcus, but is the cause of the very different infection, gonorrhea...
  24. Cannon J, Black W, Nachamkin I, Stewart P. Monoclonal antibody that recognizes an outer membrane antigen common to the pathogenic Neisseria species but not to most nonpathogenic Neisseria species. Infect Immun. 1984;43:994-9 pubmed
    ..8, that bound to all strains of Neisseria gonorrhoeae and N. meningitidis tested, and to N. lactamica and N...
  25. Troncoso G, Sanchez S, Kolberg J, Rosenqvist E, Veiga M, Ferreiros C, et al. Analysis of the expression of the putatively virulence-associated neisserial protein RmpM (class 4) in commensal Neisseria and Moraxella catarrhalis strains. FEMS Microbiol Lett. 2001;199:171-6 pubmed
    The RmpM protein has been reported to be present only in pathogenic Neisseria species. In the present study we demonstrate that this protein is also present at least in N. lactamica and N. sicca strains. The N...
  26. Morand P, Bille E, Morelle S, Eugène E, Beretti J, Wolfgang M, et al. Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins. EMBO J. 2004;23:2009-17 pubmed
    Pathogenic Neisseria express type IV pili (tfp), which have been shown to play a central role in the interactions of bacteria with their environment. The regulation of piliation thus constitutes a central element in bacterial life cycle...
  27. Wolfgang W, Passaretti T, Jose R, Cole J, Coorevits A, Carpenter A, et al. Neisseria oralis sp. nov., isolated from healthy gingival plaque and clinical samples. Int J Syst Evol Microbiol. 2013;63:1323-8 pubmed publisher
    ..7-100?%, and the closest species with a validly published name was Neisseria lactamica (96.9?% similarity to the type strain)...
  28. Jordan P, Snyder L, Saunders N. Diversity in coding tandem repeats in related Neisseria spp. BMC Microbiol. 2003;3:23 pubmed
    ..Coding tandem repeats appear to represent a largely unexplored mechanism of generating diversity in the Neisseria spp.
  29. Treangen T, Ambur O, Tonjum T, Rocha E. The impact of the neisserial DNA uptake sequences on genome evolution and stability. Genome Biol. 2008;9:R60 pubmed publisher
    Efficient natural transformation in Neisseria requires the presence of short DNA uptake sequences (DUSs). Doubts remain whether DUSs propagate by pure selfish molecular drive or are selected for 'safe sex' among conspecifics...
  30. Harrison O, Bennett J, Derrick J, Maiden M, Bayliss C. Distribution and diversity of the haemoglobin-haptoglobin iron-acquisition systems in pathogenic and non-pathogenic Neisseria. Microbiology. 2013;159:1920-30 pubmed publisher
    ..deposited in a Bacterial Isolate Genome Sequence Database (BIGSDB), the prevalence and diversity of HpuAB among Neisseria were investigated...
  31. Børud B, Aas F, Vik A, Winther Larsen H, Egge Jacobsen W, Koomey M. Genetic, structural, and antigenic analyses of glycan diversity in the O-linked protein glycosylation systems of human Neisseria species. J Bacteriol. 2010;192:2816-29 pubmed publisher
    ..a systematic approach was devised to correlate gene repertoire with protein-associated glycoform structure in Neisseria species important to human health and disease...
  32. Ward M, Lambden P, Heckels J. Sequence analysis and relationships between meningococcal class 3 serotype proteins and other porins from pathogenic and non-pathogenic Neisseria species. FEMS Microbiol Lett. 1992;73:283-9 pubmed
    The presence of highly conserved regions within previously determined porin gene sequences from Neisseria meningitidis and Neisseria gonorrhoeae permitted the construction of oligonucleotide primers for PCR amplification of other ..
  33. Zhou J, Bowler L, Spratt B. Interspecies recombination, and phylogenetic distortions, within the glutamine synthetase and shikimate dehydrogenase genes of Neisseria meningitidis and commensal Neisseria species. Mol Microbiol. 1997;23:799-812 pubmed
    ..interspecies recombinational exchanges between the meningococcal aroE and glnA genes and those of commensal Neisseria species...
  34. Qvarnstrom Y, Swedberg G. Variations in gene organization and DNA uptake signal sequence in the folP region between commensal and pathogenic Neisseria species. BMC Microbiol. 2006;6:11 pubmed
    Horizontal gene transfer is an important source of genetic variation among Neisseria species and has contributed to the spread of resistance to penicillin and sulfonamide drugs in the pathogen Neisseria meningitidis...
  35. Labbe D, Höltke H, Lau P. Cloning and characterization of two tandemly arranged DNA methyltransferase genes of Neisseria lactamica: an adenine-specific M.NlaIII and a cytosine-type methylase. Mol Gen Genet. 1990;224:101-10 pubmed
    The gene encoding the Neisseria lactamica III DNA methyltransferase (M.NlaIII) which recognizes the sequence CATG has been cloned and expressed in Escherichia coli. DNA sequencing of a 3.125 kb EcoRI-PstI fragment localizes the M...
  36. Grifantini R, Bartolini E, Muzzi A, Draghi M, Frigimelica E, Berger J, et al. Gene expression profile in Neisseria meningitidis and Neisseria lactamica upon host-cell contact: from basic research to vaccine development. Ann N Y Acad Sci. 2002;975:202-16 pubmed
    Differential gene regulation in the human pathogen Neisseria meningitidis group B (MenB) and in Neisseria lactamica, a human commensal species, was studied by whole genome microarray after bacterial interaction with epithelial cells...
  37. Hauck C, Meyer T. 'Small' talk: Opa proteins as mediators of Neisseria-host-cell communication. Curr Opin Microbiol. 2003;6:43-9 pubmed
    Opa proteins are variable outer membrane proteins of Neisseria gonorrhoeae and Neisseria meningitidis that mediate tight interaction of these pathogens with human cells...
  38. Goh L, Barkham T, Sim T. Molecular cloning and functional characterization of fumarases C in Neisseria species. Antonie Van Leeuwenhoek. 2005;87:205-13 pubmed publisher
    ..In this study, the fumC genes that encode fumarase C (FUMCs) from Neisseria meningitidis, N. gonorrhoeae and N...
  39. Jain S, Moscicka K, Bos M, Pachulec E, Stuart M, Keegstra W, et al. Structural characterization of outer membrane components of the type IV pili system in pathogenic Neisseria. PLoS ONE. 2011;6:e16624 pubmed publisher
    Structures of the type IV pili secretin complexes from Neisseria gonorrhoeae and Neisseria meningitidis, embedded in outer membranes were investigated by transmission electron microscopy...
  40. Mirza O, Skov L, Remaud Simeon M, Potocki de Montalk G, Albenne C, Monsan P, et al. Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose. Biochemistry. 2001;40:9032-9 pubmed
    The structure of amylosucrase from Neisseria polysaccharea in complex with beta-D-glucose has been determined by X-ray crystallography at a resolution of 1.66 A...
  41. Maiden M, Malorny B, Achtman M. A global gene pool in the neisseriae. Mol Microbiol. 1996;21:1297-8 pubmed
  42. Bourbeau P, Holla V, Piemontese S. Ophthalmia neonatorum caused by Neisseria cinerea. J Clin Microbiol. 1990;28:1640-1 pubmed
    b>Neisseria cinerea is an organism that has only recently been implicated as a human pathogen. In this case, N. cinerea was identified as the cause of ophthalmia neonatorum (conjunctivitis) in a 2-day-old girl.
  43. Furmanek B, Gromek K, Sektas M, Kaczorowski T. Isolation and characterization of type IIS restriction endonuclease from Neisseria cuniculi ATCC 14688. FEMS Microbiol Lett. 2001;196:171-6 pubmed
    b>Neisseria cuniculi produces the restriction enzyme NcuI which is an isoschizomer of MboII...
  44. John C, Liu M, Phillips N, Yang Z, Funk C, Zimmerman L, et al. Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals. Infect Immun. 2012;80:4014-26 pubmed publisher
    The interaction of the immune system with Neisseria commensals remains poorly understood...
  45. Spratt B, Zhang Q, Jones D, Hutchison A, Brannigan J, Dowson C. Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis. Proc Natl Acad Sci U S A. 1989;86:8988-92 pubmed
    Non-beta-lactamase-producing, penicillin-resistant strains of Neisseria meningitidis produce altered forms of penicillin-binding protein 2 that have decreased affinity for penicillin...
  46. Orús P, Vinas M. Mechanisms other than penicillin-binding protein-2 alterations may contribute to moderate penicillin resistance in Neisseria meningitidis. Int J Antimicrob Agents. 2001;18:113-9 pubmed
    Penicillin resistance in Neisseria spp is thought to be generated by the interspecies transfer of genetic material from naturally penicillin-resistant, commensal species...
  47. Mickelsen P, Sparling P. Ability of Neisseria gonorrhoeae, Neisseria meningitidis, and commensal Neisseria species to obtain iron from transferrin and iron compounds. Infect Immun. 1981;33:555-64 pubmed
    The ability of Neisseria species to use iron compounds and to compete with iron-binding proteins was examined with deferrated defined medium and the iron chelator deferoxamine...
  48. Ilina E, Borovskaya A, Malakhova M, Vereshchagin V, Kubanova A, Kruglov A, et al. Direct bacterial profiling by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry for identification of pathogenic Neisseria. J Mol Diagn. 2009;11:75-86 pubmed publisher
    ..the suitability of direct bacterial profiling as a tool for the identification and subtyping of pathogenic Neisseria. The genus Neisseria includes two human pathogens, Neisseria meningitidis and Neisseria gonorrhoeae, as well as ..
  49. Qvarnstr m Y, Swedberg G. Sulphonamide resistant commensal Neisseria with alterations in the dihydropteroate synthase can be isolated from carriers not exposed to sulphonamides. BMC Microbiol. 2002;2:34 pubmed
    Development of sulphonamide resistance in Neisseria meningitidis has been suggested to involve horizontal DNA-transfer from a commensal Neisseria species...
  50. Genco C, Desai P. Iron acquisition in the pathogenic Neisseria. Trends Microbiol. 1996;4:179-84 pubmed
    Pathogenic Neisseria species need to obtain iron from the host to grow in vivo. Several iron-transport systems are known, and regulation of Neisseria iron-transport genes occurs via the transcriptional regulator Fur...
  51. Aho E, Keating A, McGillivray S. A comparative analysis of pilin genes from pathogenic and nonpathogenic Neisseria species. Microb Pathog. 2000;28:81-8 pubmed
    Pathogenic Neisseria species elaborate type IV pili, which are considered important for virulence. In this study, we examined pilin-encoding expression loci (pilE) in nonpathogenic Neisseria species...
  52. Mazzone M, De Gregorio E, Lavitola A, Pagliarulo C, Alifano P, Di Nocera P. Whole-genome organization and functional properties of miniature DNA insertion sequences conserved in pathogenic Neisseriae. Gene. 2001;278:211-22 pubmed
    ..These DNA repeats, that we call nemis (for neisseria miniature insertion sequences) can be sorted into two major size classes...
  53. O dwyer C, Reddin K, Martin D, Taylor S, Gorringe A, Hudson M, et al. Expression of heterologous antigens in commensal Neisseria spp.: preservation of conformational epitopes with vaccine potential. Infect Immun. 2004;72:6511-8 pubmed
    Commensal neisseriae share with Neisseria meningitidis (meningococcus) a tendency towards overproduction of the bacterial outer envelope, leading to the formation and release during growth of outer membrane vesicles (OMVs)...
  54. Facius D, Meyer T. A novel determinant (comA) essential for natural transformation competence in Neisseria gonorrhoeae and the effect of a comA defect on pilin variation. Mol Microbiol. 1993;10:699-712 pubmed
    ..A novel genetic determinant (comA) has been identified and found to be required for the transformation of piliated Neisseria gonorrhoeae...
  55. Otto B, Verweij Van Vught A, MacLaren D. Transferrins and heme-compounds as iron sources for pathogenic bacteria. Crit Rev Microbiol. 1992;18:217-33 pubmed
    ..In this review, the nonsiderophore-mediated iron-uptake systems used by certain pathogenic bacteria are emphasized. The possible contribution of these iron-uptake systems to the virulence of pathogens is also discussed...
  56. Zhu P, Klutch M, Derrick J, Prince S, Tsang R, Tsai C. Identification of opcA gene in Neisseria polysaccharea: interspecies diversity of Opc protein family. Gene. 2003;307:31-40 pubmed
    ..the outer membrane adhesin/invasin protein OpcA was previously described in the genomes of two pathogenic Neisseria species, N. meningitidis (Nm) and N. gonorrhoeae (Ng)...
  57. Toleman M, Aho E, Virji M. Expression of pathogen-like Opa adhesins in commensal Neisseria: genetic and functional analysis. Cell Microbiol. 2001;3:33-44 pubmed
    ..We have investigated structural and functional similarities between adhesins of Cn and of Neisseria meningitidis (Nm), also a frequent colonizer of the nasopharynx...
  58. Bowler L, Zhang Q, Riou J, Spratt B. Interspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation. J Bacteriol. 1994;176:333-7 pubmed
    The penicillin-binding protein 2 genes (penA) of penicillin-resistant Neisseria meningitidis have a mosaic structure that has arisen by the introduction of regions from the penA genes of Neisseria flavescens or Neisseria cinerea...
  59. Serino L, Virji M. Genetic and functional analysis of the phosphorylcholine moiety of commensal Neisseria lipopolysaccharide. Mol Microbiol. 2002;43:437-48 pubmed
    Phosphorylcholine (ChoP) is a common surface feature of many mucosal organisms, including Neisseria spp., in which it is present exclusively on pili of pathogenic Neisseria and on the lipopolysaccharide (LPS) of commensal Neisseria (Cn)...
  60. Schryvers A, Stojiljkovic I. Iron acquisition systems in the pathogenic Neisseria. Mol Microbiol. 1999;32:1117-23 pubmed
    ..The receptors are potentially ideal vaccine targets in view of their critical role in survival in the host. Preliminary pilot studies indicate that transferrin receptor-based vaccines may be protective in humans...
  61. Spratt B, Bowler L, Zhang Q, Zhou J, Smith J. Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species. J Mol Evol. 1992;34:115-25 pubmed
    The two pathogenic species of Neisseria, N. meningitidis and N. gonorrhoeae, have evolved resistance to penicillin by alterations in chromosomal genes encoding the high molecular weight penicillin-binding proteins, or PBPs...
  62. Snyder L, Butcher S, Saunders N. Comparative whole-genome analyses reveal over 100 putative phase-variable genes in the pathogenic Neisseria spp. Microbiology. 2001;147:2321-32 pubmed
    Previously, a complete genome analysis of Neisseria meningitidis strain MC58 revealed the largest repertoire of putative phase-variable genes described in any species to date. Initial comparisons with two incomplete Neisseria spp...
  63. T njum T, Freitag N, Namork E, Koomey M. Identification and characterization of pilG, a highly conserved pilus-assembly gene in pathogenic Neisseria. Mol Microbiol. 1995;16:451-64 pubmed
    Expression of type IV pili appears to be a requisite determinant of infectivity for the strict human pathogens Neisseria gonorrhoeae and Neisseria meningitidis. The assembly of these colonization factors is a complex process...
  64. Yu C, Genco C. Fur-mediated global regulatory circuits in pathogenic Neisseria species. J Bacteriol. 2012;194:6372-81 pubmed publisher
    ..Whereas the repressive mechanism of Fur has been thoroughly investigated, emerging studies on direct and indirect Fur-mediated activation mechanisms have revealed novel global regulatory circuits...
  65. Peak I, Jennings M, Hood D, Bisercic M, Moxon E. Tetrameric repeat units associated with virulence factor phase variation in Haemophilus also occur in Neisseria spp. and Moraxella catarrhalis. FEMS Microbiol Lett. 1996;137:109-14 pubmed
    ..probes corresponding to five tandem copies of each of these tetramers, we have screened three strains of Neisseria meningitidis and one each of Neisseria gonorrhoeae, Neisseria lactamica, Haemophilus parainfluenzae, Bordetella ..
  66. Furmanek B, Sektas M, Wons E, Kaczorowski T. Molecular characterization of the DNA methyltransferase M1.NcuI from Neisseria cuniculi ATCC 14688. Res Microbiol. 2007;158:164-74 pubmed
    The methyltransferase M1.NcuI is a member of the restriction-modification system in Neisseria cuniculi ATCC14688 and recognizes the asymmetric pentanucleotide sequence 5'-GAAGA-3'/3'-CTTCT-5'. We purified M1...
  67. Roberts M, Chung W, Roe D, Xia M, Marquez C, Borthagaray G, et al. Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes. Antimicrob Agents Chemother. 1999;43:1367-72 pubmed
    Two Neisseria gonorrhoeae isolates from Seattle and two isolates from Uruguay were resistant to erythromycin (MIC, 4 to 16 microg/ml) and had reduced susceptibility to azithromycin (MIC, 1 to 4 microg/ml) due to the presence of the self-..
  68. Davidsen T, Rødland E, Lagesen K, Seeberg E, Rognes T, Tønjum T. Biased distribution of DNA uptake sequences towards genome maintenance genes. Nucleic Acids Res. 2004;32:1050-8 pubmed
    ..We have made a rigorous search for repeat genomic sequences in the human pathogens Neisseria meningitidis, Neisseria gonorrhoeae and Haemophilus influenzae and found that by far the most frequent 9-10mers ..
  69. Wang H, Wu M, Ko T, Wang A. Neisseria conserved hypothetical protein DMP12 is a DNA mimic that binds to histone-like HU protein. Nucleic Acids Res. 2013;41:5127-38 pubmed publisher
    ..Here, we present evidence that the Neisseria conserved hypothetical protein DMP12 should be added to this list...
  70. De Gregorio E, Abrescia C, Carlomagno M, Di Nocera P. Asymmetrical distribution of Neisseria miniature insertion sequence DNA repeats among pathogenic and nonpathogenic Neisseria strains. Infect Immun. 2003;71:4217-21 pubmed
    b>Neisseria miniature insertion sequences (nemis) are miniature DNA insertion sequences found in Neisseria species...
  71. Johannessen C, Koomey M, Børud B. Hypomorphic glycosyltransferase alleles and recoding at contingency loci influence glycan microheterogeneity in the protein glycosylation system of Neisseria species. J Bacteriol. 2012;194:5034-43 pubmed publisher
    ..has been reported for the broad-spectrum, O-linked protein glycosylation system in species within the genus Neisseria. To elucidate the mechanisms involved, a genetic approach was used to identify a hypomorphic allele of pglA (..
  72. Zhu P, Boykins R, Tsai C. Genetic and functional analyses of the lgtH gene, a member of the beta-1,4-galactosyltransferase gene family in the genus Neisseria. Microbiology. 2006;152:123-34 pubmed publisher
    Lipooligosaccharide (LOS) is a major virulence factor of the pathogenic Neisseria. Three galactosyltransferase genes, lgtB, lgtE and lgtH, responsible for the biosynthesis of LOS oligosaccharide chains, were analysed in five Neisseria ..
  73. Sanchez S, Arenas J, Abel A, Criado M, Ferreirós C. Analysis of outer membrane protein complexes and heat-modifiable proteins in Neisseria strains using two-dimensional diagonal electrophoresis. J Proteome Res. 2005;4:91-5 pubmed
    ..SDS-PAGE was used to resolve membrane complexes and identify proteins with temperature-dependent mobility in Neisseria meningitidis and N. lactamica...
  74. Gill D, Atkinson J. CD46 in Neisseria pathogenesis. Trends Mol Med. 2004;10:459-65 pubmed
  75. Perrin A, Bonacorsi S, Carbonnelle E, Talibi D, Dessen P, Nassif X, et al. Comparative genomics identifies the genetic islands that distinguish Neisseria meningitidis, the agent of cerebrospinal meningitis, from other Neisseria species. Infect Immun. 2002;70:7063-72 pubmed
    b>Neisseria meningitidis colonizes the nasopharynx and, unlike commensal Neisseria species, is capable of entering the bloodstream, crossing the blood-brain barrier, and invading the meninges...
  76. Kummeneje K. Isolation of Neisseria ovis and a Colesiota conjunctivae-like organism from cases of kerato-conjunctivitis in reindeer in northern Norway. Acta Vet Scand. 1976;17:107-8 pubmed
  77. Aspholm M, Aas F, Harrison O, Quinn D, Vik A, Viburiene R, et al. Structural alterations in a component of cytochrome c oxidase and molecular evolution of pathogenic Neisseria in humans. PLoS Pathog. 2010;6:e1001055 pubmed publisher
    Three closely related bacterial species within the genus Neisseria are of importance to human disease and health...
  78. Oliver K, Reddin K, Bracegirdle P, Hudson M, Borrow R, Feavers I, et al. Neisseria lactamica protects against experimental meningococcal infection. Infect Immun. 2002;70:3621-6 pubmed
    ..of natural immunity to meningococcal disease results from colonization of the nasopharynx by commensal Neisseria spp., particularly with N. lactamica. We report here that immunization with N...
  79. Barth K, Isabella V, Clark V. Biochemical and genomic analysis of the denitrification pathway within the genus Neisseria. Microbiology. 2009;155:4093-103 pubmed publisher
    Since Neisseria gonorrhoeae and Neisseria meningitidis are obligate human pathogens, a comparison with commensal species of the same genus could reveal differences important in pathogenesis...
  80. Rennie R, Brosnikoff C, Shokoples S, Reller L, Mirrett S, Janda W, et al. Multicenter evaluation of the new Vitek 2 Neisseria-Haemophilus identification card. J Clin Microbiol. 2008;46:2681-5 pubmed publisher
    The new Neisseria-Haemophilus identification (NH) card for Vitek 2 was compared with 16S rRNA gene sequencing (16S) as the reference method for accurate identification of Neisseria spp., Haemophilus spp...
  81. Stabler R, Hinds J. The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as virulence genes: response. BMC Genomics. 2006;7:129 pubmed
  82. Thompson S, Wang L, Sparling P. Cloning and nucleotide sequence of frpC, a second gene from Neisseria meningitidis encoding a protein similar to RTX cytotoxins. Mol Microbiol. 1993;9:85-96 pubmed
    b>Neisseria meningitidis FAM20 has recently been shown to produce two Fe-regulated proteins (FrpA and FrpC) related to the RTX family of cytotoxins...
  83. Saez Nieto J, Marcos C, Vindel A. Multicolonization of human nasopharynx due to Neisseria spp. Int Microbiol. 1998;1:59-63 pubmed
    The colonization due to Neisseria spp. in the nasopharynx of forty healthy adults was studied by using a selective medium that allows the differentiation of Neisseria species and inhibits the rest of pharyngeal microbiota...
  84. Fletcher L, Bernfield L, Barniak V, Farley J, Howell A, Knauf M, et al. Vaccine potential of the Neisseria meningitidis 2086 lipoprotein. Infect Immun. 2004;72:2088-100 pubmed
    A novel antigen that induces cross-reactive bactericidal antibodies against a number of Neisseria meningitidis strains is described...
  85. Plant L, Jonsson A. Contacting the host: insights and implications of pathogenic Neisseria cell interactions. Scand J Infect Dis. 2003;35:608-13 pubmed
    b>Neisseria is a highly adapted human specific pathogen that initiates infection at the mucosal epithelia by using multiple adhesins to interact with host cell receptors...
  86. Muzzi A, Mora M, Pizza M, Rappuoli R, Donati C. Conservation of meningococcal antigens in the genus Neisseria. MBio. 2013;4:e00163-13 pubmed publisher
    b>Neisseria meningitidis, one of the major causes of bacterial meningitis and sepsis, is a member of the genus Neisseria, which includes species that colonize the mucosae of many animals...
  87. Srikhanta Y, Dowideit S, Edwards J, Falsetta M, Wu H, Harrison O, et al. Phasevarions mediate random switching of gene expression in pathogenic Neisseria. PLoS Pathog. 2009;5:e1000400 pubmed publisher
    ..Phase-variable mod genes are also present in Neisseria meningitidis and Neisseria gonorrhoeae, suggesting that phasevarions may occur in these important human ..
  88. Corander J, Connor T, O dwyer C, Kroll J, Hanage W. Population structure in the Neisseria, and the biological significance of fuzzy species. J R Soc Interface. 2012;9:1208-15 pubmed publisher
    ..One of the most intriguing examples of this is the genus Neisseria, which comprises both pathogens and commensals colonizing a variety of body sites and host species, and causing ..
  89. Harrison O, Maiden M, Rokbi B. Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species. BMC Microbiol. 2008;8:66 pubmed publisher
    ..Two tbpB families have been documented in Neisseria meningitidis: an isotype I tbpB gene of 1.8 kb and an isotype II tbpB gene of 2...
  90. Albenne C, Skov L, Mirza O, Gajhede M, Feller G, D Amico S, et al. Molecular basis of the amylose-like polymer formation catalyzed by Neisseria polysaccharea amylosucrase. J Biol Chem. 2004;279:726-34 pubmed
    Amylosucrase from Neisseria polysaccharea is a remarkable transglucosidase from family 13 of the glycoside-hydrolases that synthesizes an insoluble amylose-like polymer from sucrose in the absence of any primer...
  91. Bakir M, Yagci A, Ulger N, Akbenlioglu C, Ilki A, Soyletir G. Asymtomatic carriage of Neisseria meningitidis and Neisseria lactamica in relation to Streptococcus pneumoniae and Haemophilus influenzae colonization in healthy children: apropos of 1400 children sampled. Eur J Epidemiol. 2001;17:1015-8 pubmed
    ..Colonization of Neisseria meningitidis and lactamica and factors affecting this carriage were determined in a group of healthy children ..