leptospira interrogans serovar icterohaemorrhagiae

Summary

Summary: A serovar of the bacterial species LEPTOSPIRA INTERROGANS, whose primary host is RATS.

Top Publications

  1. Da Silva C, Wolkmer P, Da Silva A, Paim F, Tonin A, Castro V, et al. Cholinesterases as markers of the inflammatory process in rats infected with Leptospira interrogans serovar Icterohaemorrhagiae. J Med Microbiol. 2012;61:278-84 pubmed publisher
    ..changes in the cholinesterase activity in blood, lymphocytes and serum of rats infected with Leptospira interrogans serovar Icterohaemorrhagiae ('L. icterohaemorrhagiae')...
  2. Viriyakosol S, Matthias M, Swancutt M, Kirkland T, Vinetz J. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun. 2006;74:887-95 pubmed
    ..mice, but not C3H/OuJ mice (TLR4 intact), died after intraperitoneal infection with Leptospira interrogans serovar Icterohaemorrhagiae. Death in both C3H/HeJ mouse strains was associated with jaundice and pulmonary hemorrhage, ..
  3. Velineni S, Asuthkar S, Sritharan M. Iron limitation and expression of immunoreactive outer membrane proteins in Leptospira interrogans serovar icterohaemorrhagiae strain lai. Indian J Med Microbiol. 2006;24:339-42 pubmed
  4. Colombo V, Gamietea I, Loffler S, Brihuega B, Beldomenico P. New host species for Leptospira borgpetersenii and Leptospira interrogans serovar Copenhageni. Vet Microbiol. 2018;215:90-92 pubmed publisher
    ..from Oligoryzomys nigripes, Leptospira borgpetersenii from Scapteromys aquaticus and Leptospira interrogans serovar Icterohaemorrhagiae from Akodon azarae. The zoonotic Leptospira isolated and genotyped from O. nigripes and S...
  5. Wu D, Zhang W, Wang T, Lin T, Jin X, Xie X, et al. Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. Microb Pathog. 2017;102:36-41 pubmed publisher
    ..and ciprofloxacin (1, 2 and 5 mg/kg) against leptospirosis in a hamster model using Leptospira interrogans serovar Icterohaemorrhagiae. The histopathology and bacterial loads of target organs (liver, kidney and lung) were also ..
  6. Scialfa E, Bolpe J, Bardon J, Ridao G, Gentile J, Gallicchio O. Isolation of Leptospira interrogans from suburban rats in Tandil, Buenos Aires, Argentina. Rev Argent Microbiol. 2010;42:126-8 pubmed publisher
    ..These findings showed a high density of suburban rodents highly infected with pathogenic leptospira, sharing environment in close contact with humans with evidence of leptospiral disease...
  7. Rodríguez A, Jiménez Y, Santiesteban N, Abreu Y, Osenes J, González M. [Evaluation of the vaccine potentiality of 2 strains from Leptospira interrogans serogroup Ballum]. Rev Cubana Med Trop. 2005;57:63-4 pubmed
    ..The monovalent vaccine formulations obtained showed a high immunogenicity and capacity of homologous protection and, in a lesser degree, of cross protection...
  8. Strand T, Lõhmus M, Persson Vinnersten T, Råsbäck T, Sundström K, Bergstrom T, et al. Highly Pathogenic Leptospira Found in Urban Brown Rats (Rattus norvegicus) in the Largest Cities of Sweden. Vector Borne Zoonotic Dis. 2015;15:779-81 pubmed publisher
    ..rats, captured within urban districts in Sweden, were found to be positive for antibodies to Leptospira interrogans serovar Icterohaemorrhagiae. This serovar causes Weil's disease in humans, a severe infection with jaundice, renal ..
  9. Assez N, Mauriaucourt P, Cuny J, Goldstein P, Wiel E. [Fever and jaundice... and if it was a leptospirosis. About a case of L. interrogans icterohaemorrhagiae in Northern France]. Ann Fr Anesth Reanim. 2013;32:439-43 pubmed publisher
    ..We report the case of a severe form of hepatonephritis due to water contaminated with Leptospira observed in Northern France...

More Information

Publications46

  1. Hartwig D, Forster K, Oliveira T, Amaral M, McBride A, Dellagostin O. A prime-boost strategy using the novel vaccine candidate, LemA, protects hamsters against leptospirosis. Clin Vaccine Immunol. 2013;20:747-52 pubmed publisher
    ..The DNA vaccine failed to elicit an antibody response in immunized hamsters...
  2. Roczek A, Forster C, Raschel H, Hörmansdorfer S, Bogner K, Hafner Marx A, et al. Severe course of rat bite-associated Weil's disease in a patient diagnosed with a new Leptospira-specific real-time quantitative LUX-PCR. J Med Microbiol. 2008;57:658-63 pubmed publisher
    ..Transmission of Leptospira interrogans serovar Icterohaemorrhagiae, the causative agent of Weil's disease, to humans usually results from exposure to the urine ..
  3. Serna J, Ortiz J, Servin A, Espinoza A. [Seropositivity to leptospiras in sera from patients suspected of viral hepatitis negative to serological markers]. Rev Cubana Med Trop. 2005;57:57-8 pubmed
    ..15.99 % of them were positive patients. It was observed a predominance of serovars canicola, pomona and icterohaemorrhagiae...
  4. Aydemir H, Akduman D, Oztoprak N, Piskin N, Celebi G, Akkoyunlu Y. [A severe case of Weil's disease]. Mikrobiyol Bul. 2007;41:145-50 pubmed
    ..By the administration of antibiotic therapy and early supportive care the patient was cured completely. In conclusion Weil's disease should be taken into consideration in the patients with multiple organ involvements...
  5. Murray C, Hospenthal D. Broth microdilution susceptibility testing for Leptospira spp. Antimicrob Agents Chemother. 2004;48:1548-52 pubmed
    ..of our methods was assessed with 11 runs over numerous days with a single isolate of Leptospira interrogans serovar Icterohaemorrhagiae. By either method, the MICs for these internal-validity runs fell within 2 dilutions of each ..
  6. Klaasen H, Molkenboer M, Vrijenhoek M, Kaashoek M. Duration of immunity in dogs vaccinated against leptospirosis with a bivalent inactivated vaccine. Vet Microbiol. 2003;95:121-32 pubmed
    ..canicola bacteria, was demonstrated. It was, therefore, concluded that with this vaccine, using this vaccination schedule, a duration of immunity of 1 year can be attained against infection with both serovars...
  7. Obregón A, Fernandez C, Rodríguez I, Rodriguez J. The application of monoclonal antibody methodology as a tool for serotyping leptospira isolates in Cuba. Rev Cubana Med Trop. 2007;59:68-70 pubmed
    ..Pomona, Mozdok and Canicola serovars were the most prevalent types in these serogroups. Our study has essentially presented a validation of a monoclonal antibody method for the serotyping of Cuban leptospire isolates...
  8. de Souza A, Sztajnbok J, Marques S, Seguro A. Leptospirosis-induced meningitis and acute renal failure in a 19-month-old male child. J Med Microbiol. 2006;55:795-7 pubmed
    ..Some aspects concerning the pathogenesis and treatment of this potentially life-threatening disease are also discussed. Leptospirosis was diagnosed on the basis of history and serological tests...
  9. Gerasymchuk L, Swami A, Carpenter C, Samarapungavan D, Batke M, Kanhere R, et al. Case of fulminant leptospirosis in a renal transplant patient. Transpl Infect Dis. 2009;11:454-7 pubmed publisher
    ..This case is the third report to our knowledge of leptospirosis in a renal transplant recipient in the English literature...
  10. Minke J, Bey R, Tronel J, Latour S, Colombet G, Yvorel J, et al. Onset and duration of protective immunity against clinical disease and renal carriage in dogs provided by a bi-valent inactivated leptospirosis vaccine. Vet Microbiol. 2009;137:137-45 pubmed publisher
    ..This vaccine should provide veterinarians with a powerful tool to prevent clinical disease in dogs and zoonotic transmission of leptospirosis to humans...
  11. Meri T, Murgia R, Stefanel P, Meri S, Cinco M. Regulation of complement activation at the C3-level by serum resistant leptospires. Microb Pathog. 2005;39:139-47 pubmed
    ..Thus, binding of this major alternative complement pathway inhibitor is related to serum resistance in Leptospira spirochetes...
  12. Blum Domínguez S, Chi Dzib M, Maldonado Velázquez M, Nuñez Oreza L, Gómez Solano M, Caballero Poot R, et al. Detection of reactive canines to Leptospira in Campeche City, Mexico. Rev Argent Microbiol. 2013;45:34-8 pubmed
    ..15 %), and Leptospira Pomona (7.89 %) were those reacting in stray dogs. Results showed that all dogs have been in contact with different Leptospira serovars and outdoor exposure is the main infection risk factor...
  13. Huits R, van der Werf T, Zijlstra J. [Clinical reasoning and decision-making in practice. A man with jaundice, renal function disorder, thrombocytopenia, muscular pain and confusion]. Ned Tijdschr Geneeskd. 2004;148:1137-41 pubmed
    ..Leptospirosis, a multi-organ disease is seen ever more infrequently as an occupational disease in stock farmers and increasingly frequently in people whose hobbies involved animals...
  14. Rodríguez I, Rodriguez J, Fernandez C. [Alkalinization of human urine for the experimental isolation of leptospiras]. Rev Cubana Med Trop. 2005;57:55-6 pubmed
    ..The effect of different alkalizing agents of urine on the isolation of leptospiras was studied. Better results were obtained on using the basic solution of NaOH 1N inoculated in urine one hour after being alkalized...
  15. Maneewatch S, Tapchaisri P, Sakolvaree Y, Klaysing B, Tongtawe P, Chaisri U, et al. OmpL1 DNA vaccine cross-protects against heterologous Leptospira spp. challenge. Asian Pac J Allergy Immunol. 2007;25:75-82 pubmed
    ..While the results are encouraging, further studies are needed to optimize the immunization schedule, vaccine dosage and formulation in order to maximize the efficacy of the vaccine...
  16. Agudelo Florez P, Restrepo Jaramillo B, Arboleda Naranjo M. [Leptospirosis in Uraba, Antioquia, Colombia: a seroepidemiological and risk factor survey in the urban population]. Cad Saude Publica. 2007;23:2094-102 pubmed
    ..In conclusion, there is a high prevalence of Leptospira spp. antibodies in the area, where it is thus necessary to establish control measures to decrease the risk of environmental exposure to leptospirosis...
  17. Gonzalez A, Rodriguez Y, Batista N, Valdes Y, Nunez J, Mirabal M, et al. [Immunogenicity and protective capacity of leptospiral whole-cell monovalent serogroup Ballum vaccines in hamsters]. Rev Argent Microbiol. 2005;37:169-75 pubmed
  18. Johnson R, Rogers P. DIFFERENTIATION OF PATHOGENIC AND SAPROPHYTIC LEPTOSPIRES WITH 8-AZAGUANINE. J Bacteriol. 1964;88:1618-23 pubmed
    ..L. andaman CH11, L. semarang Veldrat S1 73, and L. andaman Correa, were classified with the L. biflexa strains on the basis of their growth response to 8-azaguanine...
  19. Klaasen H, van der Veen M, Molkenboer M, Bruderer U. Development of Leptospira in vitro potency assays: EU/industry experience and perspectives. Biologicals. 2013;41:315-22 pubmed publisher
    ..The recent approval of these assays for a new canine leptospirosis vaccine is an important contribution to the 3Rs in quality control testing of Leptospira vaccines...
  20. Herrmann Storck C, Saint Louis M, Foucand T, Lamaury I, Deloumeaux J, Baranton G, et al. Severe leptospirosis in hospitalized patients, Guadeloupe. Emerg Infect Dis. 2010;16:331-4 pubmed publisher
  21. Blanco R, Dos Santos L, Galloway R, Romero E. Is the microagglutination test (MAT) good for predicting the infecting serogroup for leptospirosis in Brazil?. Comp Immunol Microbiol Infect Dis. 2016;44:34-6 pubmed publisher
    ..However, it should be complemented by the identification of Leptospira isolates. ..
  22. Karaahmetoglu S, Ciftçi A, Ozer I, Topal M, Cesur S. [A case of acute pancreatitis due to Weil's disease]. Mikrobiyol Bul. 2003;37:297-9 pubmed
    ..This case was reported to draw attention to Leptospira infections which should be considered in the differential diagnosis of patients with jaundice and pancreatitis...
  23. Landon S, Tang J. Proposal to list ATCC 43642 as the type strain of Leptospira interrogans in the Approved Lists of Bacterial Names. Request for an opinion. Int J Syst Evol Microbiol. 2004;54:2439 pubmed
    ..An authentic culture of the Leptospira interrogans serovar icterohaemorrhagiae RGA(T) strain was then submitted and assigned ATCC 43642, which was designated as the type ..
  24. Monte L, Jorge S, Xavier M, Leal F, Amaral M, Seixas F, et al. Molecular characterization of virulent Leptospira interrogans serogroup icterohaemorrhagiae isolated from Cavia aperea. Acta Trop. 2013;126:164-6 pubmed publisher
    ..In conclusion, these findings could be useful for elucidating the epidemiological role of C. aperea in leptospirosis...
  25. Matsui M, Rouleau V, Bruyère Ostells L, Goarant C. Gene expression profiles of immune mediators and histopathological findings in animal models of leptospirosis: comparison between susceptible hamsters and resistant mice. Infect Immun. 2011;79:4480-92 pubmed publisher
    ..hamster, and a resistant one, the Oncins France 1 (OF1) mouse, both infected with virulent Leptospira interrogans serovar Icterohaemorrhagiae strain Verdun...
  26. Renault P, Boidin E, D Ortenzio E, Balleydier E, Daniel B, Filleul L. [Epidemiological surveillance of leptospirosis on Reunion Island in 2004-2008: possible impact of Chikungunya infection on the case fatality rate of leptospirosis]. Bull Soc Pathol Exot. 2011;104:148-52 pubmed publisher
    ..This could be linked to the outbreak of chikungunya, which peaked in February 2006. In endemic areas of leptospirosis, health professionals should remain aware of the risk of occurrence of fatal cases during arbovirosis outbreaks...
  27. Agesilas F, Gey F, Monbrunt A, Combes J, Llanas B, Schlossmacher P, et al. [Acute leptospirosis in children in Reunion Island: a retrospective review of 16 cases]. Arch Pediatr. 2005;12:1344-8 pubmed
    ..This infectious disease known with a high incidence in Reunion island (French overseas territories in Indian Ocean) is in state of endemia especially during rains season...
  28. Jha S, Ansari M. Leptospirosis presenting as acute meningoencephalitis. J Infect Dev Ctries. 2010;4:179-82 pubmed
  29. Senthilkumar T, Subathra M, Phil M, Ramadass P, Ramaswamy V. Rapid serodiagnosis of leptospirosis by latex agglutination test and flow-through assay. Indian J Med Microbiol. 2008;26:45-9 pubmed
    ..In the present study, in order to develop a simple, rapid immunodiagnostic assay, one of the outer membrane proteins (OMPs), recombinant LipL41 (rLipL41) has been utilised in latex agglutination test (LAT) and flow-through assay...
  30. Rodriguez Gonzalez I, Fillonneau C, Blanchet B, Suard I, Catilina P, Andre Fontaine G. [Efficacy of Spirolept vaccine against human leptospirosis as estimated by passive protection of laboratory rodents]. Med Mal Infect. 2004;34:196-200 pubmed
    ..This study had for aim to assess the serological response induced by the Spirolept vaccine against human leptospirosis...
  31. Sakolvaree Y, Maneewatch S, Jiemsup S, Klaysing B, Tongtawe P, Srimanote P, et al. Proteome and immunome of pathogenic Leptospira spp. revealed by 2DE and 2DE-immunoblotting with immune serum. Asian Pac J Allergy Immunol. 2007;25:53-73 pubmed
    ..These proteins not only are the diagnostic targets but also have potential as candidates of a broad spectrum leptospirosis vaccine especially the surface exposed components which should be vulnerable to the host immune effector factors...
  32. Geisen V, Stengel C, Brem S, Muller W, Greene C, Hartmann K. Canine leptospirosis infections - clinical signs and outcome with different suspected Leptospira serogroups (42 cases). J Small Anim Pract. 2007;48:324-8 pubmed
  33. Ramos A, Souza G, Lilenbaum W. Influence of leptospirosis on reproductive performance of sows in Brazil. Theriogenology. 2006;66:1021-5 pubmed
    ..Seroreactivity for pomona was associated (P<0.05) with stillborn piglets and mummified fetuses, whereas seroreactivity to icterohaemorrhagiae was associated (P<0.05) with the number of piglets born dead...
  34. He P, Zhang X, Guo X, Hu B, Huang X, Yang Y, et al. Identification and analysis of genes present in Leptospira interrogans serovar lai but absent in L. biflexa serovar monvalerio. Acta Biochim Biophys Sin (Shanghai). 2004;36:832-9 pubmed
    ..Further analysis of these DNA sequences will provide important information on the pathogenesis of Leptospira...
  35. Dall Antonia M, Sluga G, Whitfield S, Teall A, Wilson P, Krahe D. Leptospirosis pulmonary haemorrhage: a diagnostic challenge. Emerg Med J. 2008;25:51-2 pubmed
    ..Massive haemoptysis is a life threatening complication of leptospirosis, even outside tropical areas...
  36. Leibold J, Fusco S, Feucht J, Artunc F, Malek N, Bitzer M. [Punt-driver with jaundice - case 1/2014]. Dtsch Med Wochenschr. 2014;139:28 pubmed publisher
    ..A 30-year-old student, who worked part-time as a punt-driver, was admitted to the hospital with fever up to 39.5 °C, severe pain in in his lower extremity and the lower back, nausea and jaundice...
  37. Lilenbaum W, Ristow P, Fráguas S, da Silva E. Evaluation of a rapid slide agglutination test for the diagnosis of acute canine leptospirosis. Rev Latinoam Microbiol. 2002;44:124-8 pubmed
    ..01). Concordance of results was of 93.4% (199/ 213) of the animals correctly diagnosed by RSAT. Considering MAT as the standard test, sensitivity of RSAT was calculated on 94.3% (133/141) and specificity on 91.7% (66/72)...