leptospira

Summary

Summary: A genus of aerobic, helical spirochetes, some species of which are pathogenic, others free-living or saprophytic.

Top Publications

  1. de Nardi G, Genovez M, Ribeiro M, Castro V, Jorge A. An in vitro growth inhibition test for measuring the potency of Leptospira spp. Sejroe group vaccine in buffaloes. Biologicals. 2010;38:474-8 pubmed publisher
    b>Leptospira spp. serovars Hardjo and Wollfi from Sejroe serogroup have been detected in livestock in Brazil, where the main control procedures rely on vaccination...
  2. Djelouadji Z, Roux V, Raoult D, Kodjo A, Drancourt M. Rapid MALDI-TOF mass spectrometry identification of Leptospira organisms. Vet Microbiol. 2012;158:142-6 pubmed publisher
    Leptospirosis is a worldwide deadly zoonotic disease. Accurate identification of the causative Leptospira spp. spirochetes ascertains the pathogenic status of the isolates, identifies potential source of infection and recognises outbreaks...
  3. Mathews P, da Silva V, Rosas F, d Affonseca Neto J, Lazzarini S, Ribeiro D, et al. Occurrence of antibodies to Toxoplasma gondii and Lepstospira spp. in manatees (Trichechus inunguis) of the Brazilian Amazon. J Zoo Wildl Med. 2012;43:85-8 pubmed
    The presence of Toxoplasma gondii and Leptospira spp. antibodies was investigated in 74 manatees (Trichechus inunguis [Mammalia: Sirenia]) kept in captivity in two rescue units in the northern region of Brazil. Antibodies to T...
  4. Bedir O, Kilic A, Atabek E, Kuskucu A, Turhan V, Basustaoglu A. Simultaneous detection and differentiation of pathogenic and nonpathogenic Leptospira spp. by multiplex real-time PCR (TaqMan) assay. Pol J Microbiol. 2010;59:167-73 pubmed
    Leptospirosis, caused by pathogenic Leptospira, is one of the most important zoonoses in the world. Several molecular techniques have been developed for detection and differentiation between pathogenic and saprophytic Leptospira spp...
  5. Subharat S, Wilson P, Heuer C, Collins Emerson J. Longitudinal serological survey and herd-level risk factors for Leptospira spp. serovars Hardjo-bovis and Pomona on deer farms with sheep and/or beef cattle. N Z Vet J. 2012;60:215-22 pubmed publisher
    To investigate the seroprevalence of Leptospira spp...
  6. Feng C, Li Q, Zhang X, Dong K, Hu B, Guo X. Immune strategies using single-component LipL32 and multi-component recombinant LipL32-41-OmpL1 vaccines against leptospira. Braz J Med Biol Res. 2009;42:796-803 pubmed
    Genes encoding lipoproteins LipL32, LipL41 and the outer-membrane protein OmpL1 of leptospira were recombined and cloned into a pVAX1 plasmid...
  7. Topic M, Habus J, Milas Z, Tosev E, Stritof Z, Turk N. Human leptospirosis in Croatia: current status of epidemiology and clinical characteristics. Trans R Soc Trop Med Hyg. 2010;104:202-6 pubmed publisher
    ..In comparison with previous periods, the mean yearly number of patients with leptospirosis hospitalised at UHID decreased, but among them a rather higher rate of patients with Weil's disease and a higher CFR was observed. ..
  8. Deveson Lucas D, Lo M, Bulach D, Quinsey N, Murray G, Allen A, et al. Recombinant LipL32 stimulates interferon-gamma production in cattle vaccinated with a monovalent Leptospira borgpetersenii serovar Hardjo subtype Hardjobovis vaccine. Vet Microbiol. 2014;169:163-70 pubmed publisher
    b>Leptospira borgpetersenii serovar Hardjo subtype Hardjobovis (Hardjobovis) is the main causative agent of bovine leptospirosis in Australia, New Zealand, North America and elsewhere...
  9. Carvalho E, Barbosa A, Gomez R, Cianciarullo A, Hauk P, Abreu P, et al. Leptospiral TlyC is an extracellular matrix-binding protein and does not present hemolysin activity. FEBS Lett. 2009;583:1381-5 pubmed publisher
    The role of TlyA, TlyB and TlyC proteins in the biology of Leptospira is still uncertain...

More Information

Publications104 found, 100 shown here

  1. Behera B, Chaudhry R, Pandey A, Mohan A, Dar L, Premlatha M, et al. Co-infections due to leptospira, dengue and hepatitis E: a diagnostic challenge. J Infect Dev Ctries. 2009;4:48-50 pubmed
    A case of mixed infection due to leptospira, dengue and hepatitis E is reported. Similar clinical presentation and simultaneous transmission of these diseases during rainy season can cause substantial misdiagnosis...
  2. Koizumi N, Gamage C, Muto M, Kularatne S, Budagoda B, Rajapakse R, et al. Serological and genetic analysis of leptospirosis in patients with acute febrile illness in kandy, sri lanka. Jpn J Infect Dis. 2009;62:474-5 pubmed
    ..2%). Leptospiral DNA was detected in 3 of the 107 serum samples. The deduced leptospiral species were Leptospira interrogans and L. kirschneri (2 and 1 samples, respectively)...
  3. Tulsiani S, Cobbold R, Graham G, Dohnt M, Burns M, Leung L, et al. The role of fruit bats in the transmission of pathogenic leptospires in Australia. Ann Trop Med Parasitol. 2011;105:71-84 pubmed publisher
    ..Stringent quantitative risk analysis of the present and similar data, to explore their implications in terms of disease prevalence and wildlife population dynamics, is recommended. ..
  4. Sapian M, Khair M, How S, Rajalingam R, Sahhir K, Norazah A, et al. Outbreak of melioidosis and leptospirosis co-infection following a rescue operation. Med J Malaysia. 2012;67:293-7 pubmed
    ..3% in professional rescuers. The soil and water samples in Lubuk Yu recreational area were positive for leptospira and Burkholderia pseudomallei...
  5. Leon A, Pronost S, Fortier G, André Fontaine G, Leclercq R. Multilocus sequence analysis for typing Leptospira interrogans and Leptospira kirschneri. J Clin Microbiol. 2010;48:581-5 pubmed publisher
    Fifty-three strains belonging to the pathogenic species Leptospira interrogans and Leptospira kirschneri were analyzed by multilocus sequence analysis. The species formed two distinct branches. In the L...
  6. Niller H. Myelodysplastic syndrome (MDS) as a late stage of subclinical hemophagocytic lymphohistiocytosis (HLH): a putative role for Leptospira infection. A hypothesis. Acta Microbiol Immunol Hung. 2010;57:181-9 pubmed publisher
    ..In rare and extreme cases, Leptospira infection causes severe and life-threatening HLH...
  7. Natarajaseenivasan K, Vedhagiri K, Sivabalan V, Prabagaran S, Sukumar S, Artiushin S, et al. Seroprevalence of Leptospira borgpetersenii serovar javanica infection among dairy cattle, rats and humans in the Cauvery river valley of southern India. Southeast Asian J Trop Med Public Health. 2011;42:679-86 pubmed
    ..RAPD comparisons and secY gene sequencing identified these isolates as Leptospira borgpetersenii. These results altogether indicated that L...
  8. Jorge S, Hartleben C, Seixas F, Coimbra M, Stark C, Larrondo A, et al. Leptospira borgpetersenii from free-living white-eared opossum (Didelphis albiventris): first isolation in Brazil. Acta Trop. 2012;124:147-51 pubmed publisher
    Leptospirosis is a zoonotic disease that occurs all over the world, caused by bacteria of the genus Leptospira. Marsupial and didelphidae families are considered susceptible to infection caused by a wide range of Leptospira serovars for ..
  9. Whitney E, Ailes E, Myers L, Saliki J, Berkelman R. Prevalence of and risk factors for serum antibodies against Leptospira serovars in US veterinarians. J Am Vet Med Assoc. 2009;234:938-44 pubmed publisher
    To determine the seroprevalence of antibodies against Leptospira serovars among veterinarians and identify risk factors for seropositivity in veterinary care settings. Seroepidemiologic survey...
  10. Barmettler R, Schweighauser A, Bigler S, Grooters A, Francey T. Assessment of exposure to Leptospira serovars in veterinary staff and dog owners in contact with infected dogs. J Am Vet Med Assoc. 2011;238:183-8 pubmed publisher
    To assess patterns of seroreactivity to Leptospira serovars in veterinary professional staff and dog owners exposed to dogs with acute leptospirosis and to contrast these patterns in people with those observed in dogs...
  11. Monahan A, Callanan J, Nally J. Review paper: Host-pathogen interactions in the kidney during chronic leptospirosis. Vet Pathol. 2009;46:792-9 pubmed publisher
    Pathogenic species of Leptospira cause leptospirosis, a global zoonotic disease...
  12. Yalin W, Lingbing Z, Hongliang Y, Jianmin X, Xiangyan Z, Xiaokui G, et al. High prevalence of pathogenic Leptospira in wild and domesticated animals in an endemic area of China. Asian Pac J Trop Med. 2011;4:841-5 pubmed publisher
    To assess the prevalence of Leptospira detected in wildlife and domesticated animals in Jiangxi Province, China, in...
  13. Sales I, Folly M, Garcia L, Ramos T, da Silva M, Pereira M. Leptospira and Brucella antibodies in collared anteaters (Tamandua tetradactyla) in Brazilian zoos. J Zoo Wildl Med. 2012;43:739-43 pubmed
    The presence of Leptospira spp. and Brucella spp. antibodies was investigated in serum samples from 28 collared anteaters (Tamandua tetradactyla) kept in seven Brazilian zoos...
  14. Båverud V, Gunnarsson A, Engvall E, Franzen P, Egenvall A. Leptospira seroprevalence and associations between seropositivity, clinical disease and host factors in horses. Acta Vet Scand. 2009;51:15 pubmed publisher
    A cross-sectional study was carried out to determine the seroprevalence of different serovars of Leptospira spp. and their association with clinical disease and host factors in Swedish horses...
  15. Adler B, Lo M, Seemann T, Murray G. Pathogenesis of leptospirosis: the influence of genomics. Vet Microbiol. 2011;153:73-81 pubmed publisher
    Leptospirosis is the most widespread zoonosis worldwide and is caused by serovars of pathogenic Leptospira species. The understanding of leptospiral pathogenesis lags far behind that of many other bacterial pathogens...
  16. Oliveira Lavinsky M, Said R, Strenzel G, Langoni H. Seroprevalence of anti-Leptospira spp. antibodies in dogs in Bahia, Brazil. Prev Vet Med. 2012;106:79-84 pubmed publisher
    The aim of this study was to determine the prevalence of anti-Leptospira spp. antibodies in dogs living in the urban area of the city of Ilhéus, Bahia, Brazil using the microscopic agglutination test (MAT) to investigate 24 serovars...
  17. Suepaul S, Carrington C, Campbell M, Borde G, Adesiyun A. Serovars of Leptospira isolated from dogs and rodents. Epidemiol Infect. 2010;138:1059-70 pubmed publisher
    We determined the frequency of isolation of Leptospira from dogs and rodents, the serovars of Leptospira, and the clinical, gross and histological manifestations in dogs with leptospirosis in Trinidad...
  18. Subharat S, Wilson P, Heuer C, Collins Emerson J. Evaluation of a SYTO9 real-time polymerase chain reaction assay to detect and identify pathogenic Leptospira species in kidney tissue and urine of New Zealand farmed deer. J Vet Diagn Invest. 2011;23:743-52 pubmed publisher
    A SYTO9 real-time polymerase chain reaction assay for detection of pathogenic Leptospira spp...
  19. da Silva J, Carvalho E, Covarrubias A, Ching A, Mattaraia V, Paiva D, et al. Induction of TNF-alfa and CXCL-2 mRNAs in different organs of mice infected with pathogenic Leptospira. Microb Pathog. 2012;52:206-16 pubmed publisher
    ..resistant and susceptible mice models, C3H/HeJ, C3H/HePas and BALB/c strains, using a virulent strain of Leptospira interrogans serovar Copenhageni...
  20. Ricaldi J, Fouts D, Selengut J, Harkins D, Patra K, Moreno A, et al. Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity. PLoS Negl Trop Dis. 2012;6:e1853 pubmed publisher
    ..whole genome analysis of two strains of the first intermediately pathogenic leptospiral species to be sequenced (Leptospira licerasiae strains VAR010 and MMD0835) provides insight into their pathogenic potential and deepens our ..
  21. Alton G, Berke O, Reid Smith R, Ojkic D, Prescott J. Increase in seroprevalence of canine leptospirosis and its risk factors, Ontario 1998-2006. Can J Vet Res. 2009;73:167-75 pubmed
    ..The temporal trend analysis was consistent with an increasing proportion or re-emergence of seroprevalent cases of canine leptospirosis since 1998, suggesting that the putative increase in canine leptospirosis has been genuine. ..
  22. Subharat S, Wilson P, Heuer C, Collins Emerson J. Growth response and shedding of Leptospira spp. in urine following vaccination for leptospirosis in young farmed deer. N Z Vet J. 2012;60:14-20 pubmed publisher
    To investigate the effect of vaccination against Leptospira serovars Hardjo-bovis and Pomona on growth rate and shedding of leptospires in urine in rising 1-year-old farmed red deer.
  23. Ivanova S, Herbreteau V, Blasdell K, Chaval Y, Buchy P, Guillard B, et al. Leptospira and rodents in Cambodia: environmental determinants of infection. Am J Trop Med Hyg. 2012;86:1032-8 pubmed publisher
    We investigated infection of rodents and shrews by Leptospira spp...
  24. Tanganuchitcharnchai A, Smythe L, Dohnt M, Hartskeerl R, Vongsouvath M, Davong V, et al. Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR. Trans R Soc Trop Med Hyg. 2012;106:563-6 pubmed publisher
    The diagnostic utility of the Standard Diagnostics Leptospira IgM ELISA for detection of acute leptospirosis was assessed in febrile adults admitted in Vientiane, Laos...
  25. Ribeiro R, Machry L, Brazil J, Ramos T, Avelar K, Pereira M. Technical improvement to prevent DNA degradation of Leptospira spp. in pulsed field gel electrophoresis. Lett Appl Microbiol. 2009;49:289-91 pubmed publisher
    Leptospirosis is a public health problem. Infection with pathogenic Leptospira occurs by exposure to many environments and is traditionally associated with occupational risk activities...
  26. Robertson C, Nelson T, Stephen C. Spatial epidemiology of suspected clinical leptospirosis in Sri Lanka. Epidemiol Infect. 2012;140:731-43 pubmed publisher
    ..The role of rainfall in the outbreak remains to be investigated, although analysis here suggests a more complex relationship than simple correlation...
  27. Lo Y, Hsu S, Ko Y, Hung C, Chang M, Hsu H, et al. Essential calcium-binding cluster of Leptospira LipL32 protein for inflammatory responses through the Toll-like receptor 2 pathway. J Biol Chem. 2013;288:12335-44 pubmed publisher
    Leptospirosis is the most widespread zoonosis caused by the pathogenic Leptospira worldwide...
  28. Ko A, Goarant C, Picardeau M. Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen. Nat Rev Microbiol. 2009;7:736-47 pubmed publisher
    ..One hundred years after the discovery of the causative spirochaetal agent, little is understood about Leptospira spp...
  29. Amilasan A, Ujiie M, Suzuki M, Salva E, Belo M, Koizumi N, et al. Outbreak of leptospirosis after flood, the Philippines, 2009. Emerg Infect Dis. 2012;18:91-4 pubmed publisher
    ..8%) died. A hospital-based investigation found risk factors associated with fatal infection to be older age, hemoptysis, anuria, jaundice, and delayed treatment with antimicrobial drugs...
  30. Villumsen S, Pedersen R, Borre M, Ahrens P, Jensen J, Krogfelt K. Novel TaqMan® PCR for detection of Leptospira species in urine and blood: pit-falls of in silico validation. J Microbiol Methods. 2012;91:184-90 pubmed publisher
    ..We report a specific real-time PCR assay for detection of Leptospira, i.e...
  31. Saito M, Villanueva S, Kawamura Y, Iida K, Tomida J, Kanemaru T, et al. Leptospira idonii sp. nov., isolated from environmental water. Int J Syst Evol Microbiol. 2013;63:2457-62 pubmed publisher
    ..The motility and morphology of the isolate were similar to those of members of the genus Leptospira, but the spiral structure of the isolate was sharper under dark-field microscopy. Cells were 10.6 ± 1...
  32. Rosario L, Arencibia D, Suarez Y, Infante J, Valdés B, Batista N. Cross-protection among unrelated leptospira pathogens serovars: an unfinished story. Adv Clin Exp Med. 2012;21:581-9 pubmed
    ..The results of this research demonstrated that a cross-protection among unrelated Leptospira serovars strain is possible...
  33. Marcsisin R, Bartpho T, Bulach D, Srikram A, Sermswan R, Adler B, et al. Use of a high-throughput screen to identify Leptospira mutants unable to colonize the carrier host or cause disease in the acute model of infection. J Med Microbiol. 2013;62:1601-8 pubmed publisher
    ..All virulence factors identified in Leptospira to date have been characterized in the acute model of infection, neglecting the carrier host...
  34. Turk N, Milas Z, Mojcec V, Ruzic Sabljic E, Staresina V, Stritof Z, et al. Molecular analysis of Leptospira spp. isolated from humans by restriction fragment length polymorphism, real-time PCR and pulsed-field gel electrophoresis. FEMS Microbiol Lett. 2009;300:174-9 pubmed publisher
    A total of 17 Leptospira clinical strains isolated from humans in Croatia were serologically and genetically analysed...
  35. Yan W, Faisal S, McDonough S, Chang C, Pan M, Akey B, et al. Identification and characterization of OmpA-like proteins as novel vaccine candidates for Leptospirosis. Vaccine. 2010;28:2277-83 pubmed publisher
    b>Leptospira is an important infectious Gram-negative bacterium causing Leptospirosis in mammals. Outer membrane proteins (OMPs) are key molecules in the interface between the cell and its environment...
  36. Gautam R, Wu C, Guptill L, Potter A, Moore G. Detection of antibodies against Leptospira serovars via microscopic agglutination tests in dogs in the United States, 2000-2007. J Am Vet Med Assoc. 2010;237:293-8 pubmed publisher
    ..at a commercial veterinary diagnostic laboratory to determine temporal and demographic distributions of positive serologic test results for leptospirosis in dogs and identify correlations among results for various Leptospira serovars.
  37. Ridzlan F, Bahaman A, Khairani Bejo S, Mutalib A. Detection of pathogenic Leptospira from selected environment in Kelantan and Terengganu, Malaysia. Trop Biomed. 2010;27:632-8 pubmed
    ..Pathogenic leptospires can be detected in Malaysian environment and this has the potential to cause an outbreak. Therefore, precautionary steps against leptospirosis should be taken by camp authorities to ensure the safety of trainees...
  38. Toma C, Okura N, Takayama C, Suzuki T. Characteristic features of intracellular pathogenic Leptospira in infected murine macrophages. Cell Microbiol. 2011;13:1783-92 pubmed publisher
    b>Leptospira interrogans is a spirochaete responsible for a zoonotic disease known as leptospirosis...
  39. Viau E, Boehm A. Quantitative PCR-based detection of pathogenic Leptospira in Hawai'ian coastal streams. J Water Health. 2011;9:637-46 pubmed publisher
    Pathogenic Leptospira, the causative agents of leptospirosis, are mainly associated with tropical freshwaters, but little is known about their fate in the environment...
  40. Klaasen H, van der Veen M, Molkenboer M, Sutton D. A novel tetravalent Leptospira bacterin protects against infection and shedding following challenge in dogs. Vet Rec. 2013;172:181 pubmed publisher
    ..suggests that vaccines against canine leptospirosis in Europe should be directed against infection with Leptospira interrogans (sensu lato) serogroups Canicola, Icterohaemorrhagiae, Grippotyphosa and Australis...
  41. Adler B, de la Peña Moctezuma A. Leptospira and leptospirosis. Vet Microbiol. 2010;140:287-96 pubmed publisher
    ..spread zoonosis worldwide; it is present in all continents except Antarctica and evidence for the carriage of Leptospira has been found in virtually all mammalian species examined...
  42. Bessa T, Spichler A, Chapola E, Husch A, de Almeida M, Sodré M, et al. The contribution of bats to leptospirosis transmission in Sao Paulo City, Brazil. Am J Trop Med Hyg. 2010;82:315-7 pubmed publisher
    ..Previous data indicate the potential for bats to act as carriers of Leptospira in regions such as the Amazon of South America and in Australia...
  43. Cai C, Zhu Y, Zhong Y, Xin X, Jiang X, Lou X, et al. Development of O-antigen gene cluster-specific PCRs for rapid typing six epidemic serogroups of Leptospira in China. BMC Microbiol. 2010;10:67 pubmed publisher
    b>Leptospira is the causative agent of leptospirosis. The O-antigen is the distal part of the lipopolysaccharide, which is a key component of outer membrane of Gram-negative bacteria and confers serological specificity...
  44. Villanueva S, Ezoe H, Baterna R, Yanagihara Y, Muto M, Koizumi N, et al. Serologic and molecular studies of Leptospira and leptospirosis among rats in the Philippines. Am J Trop Med Hyg. 2010;82:889-98 pubmed publisher
    ..Using the microscopic agglutination test, we found that 92% of rat serum samples were positive for anti-Leptospira antibodies; the most common infecting serovars were Manilae, Hebdomadis, and Losbanos...
  45. Martinez Lopez D, Fahey M, Coburn J. Responses of human endothelial cells to pathogenic and non-pathogenic Leptospira species. PLoS Negl Trop Dis. 2010;4:e918 pubmed publisher
    ..The agents of leptospirosis comprise several members of the genus Leptospira, which also includes non-pathogenic, saprophytic species...
  46. Lin Y, McDonough S, Sharma Y, Chang Y. Leptospira immunoglobulin-like protein B (LigB) binding to the C-terminal fibrinogen ?C domain inhibits fibrin clot formation, platelet adhesion and aggregation. Mol Microbiol. 2011;79:1063-76 pubmed publisher
    b>Leptospira immunoglobulin-like (Lig) proteins including LigA and LigB are adhesins that bind to fibronectin, collagen, laminin and elastin...
  47. Wang F, Herzig C, Chen C, Hsu H, Baldwin C, Telfer J. Scavenger receptor WC1 contributes to the ?? T cell response to Leptospira. Mol Immunol. 2011;48:801-9 pubmed publisher
    ..The expression of receptors within the WC1.1 group correlates with the capacity of ?? T cells to respond to Leptospira antigen...
  48. Moreno N, Agudelo Florez P. [Application of conventional and multiplex PCR assays for identification of isolates of Leptospira spp. in Colombia]. Rev Peru Med Exp Salud Publica. 2010;27:548-56 pubmed
    Serological identification of Leptospira ssp isolates is difficult to achieve. Thus, molecular testing may be of great interest thanks to its high discrimination power, reproducibility and easy interpretation.
  49. Dos Santos J, Lima Ribeiro A, Oliveira P, Dos Santos M, Ferreira A, Medeiros A, et al. Seroprevalence and risk factors for Leptospirosis in goats in Uberlândia, Minas Gerais, Brazil. Trop Anim Health Prod. 2012;44:101-6 pubmed publisher
    ..The results demonstrated that inadequate management was a factor which favored the occurrence of infection in the region of the study...
  50. Jorge R, Ferreira F, Ferreira Neto J, Vasconcellos S, Lima E, Morais Z, et al. Exposure of free-ranging wild carnivores, horses and domestic dogs to Leptospira spp in the northern Pantanal, Brazil. Mem Inst Oswaldo Cruz. 2011;106:441-4 pubmed
    ..and domestic dogs on a private reserve located in the northern Pantanal (Brazil) and the surrounding areas to Leptospira spp from 2002-2006, 75 free-ranging wild carnivores were captured in the Pantanal and serum samples were ..
  51. Maneewatch S, Sakolvaree Y, Tapchaisri P, Saengjaruk P, Songserm T, Wongratanachewin S, et al. Humanized-monoclonal antibody against heterologous Leptospira infection. Protein Eng Des Sel. 2009;22:305-12 pubmed publisher
    ..from total RNA of a murine hybridoma clone secreting monoclonal antibody (MAb) specific to LipL32 of pathogenic Leptospira spp. The MAb had therapeutic efficacy in Leptospira challenged hamsters...
  52. Atzingen M, Gomez R, Schattner M, Pretre G, Gonçales A, de Morais Z, et al. Lp95, a novel leptospiral protein that binds extracellular matrix components and activates e-selectin on endothelial cells. J Infect. 2009;59:264-76 pubmed publisher
    ..The study of a predicted outer membrane leptospiral protein encoded by the gene LIC12690 in mediating the adhesion process...
  53. Lottersberger J, Guerrero S, Tonarelli G, Frank R, Tarabla H, Vanasco N. Epitope mapping of pathogenic Leptospira LipL32. Lett Appl Microbiol. 2009;49:641-5 pubmed publisher
    ..To identify LipL32 epitopes and to evaluate their capability to recognize specific antibodies using ELISA...
  54. Benschop J, Heuer C, Jaros P, Collins Emerson J, Midwinter A, Wilson P. Sero-prevalence of leptospirosis in workers at a New Zealand slaughterhouse. N Z Med J. 2009;122:39-47 pubmed
    To undertake a pilot study to measure the sero-prevalence to Leptospira serovars Hardjo and Pomona in an occupationally exposed group...
  55. Ganoza C, Matthias M, Saito M, Cespedes M, Gotuzzo E, Vinetz J. Asymptomatic renal colonization of humans in the peruvian Amazon by Leptospira. PLoS Negl Trop Dis. 2010;4:e612 pubmed publisher
    ..We hypothesized that, like mammalian reservoir hosts, humans develop asymptomatic leptospiruria in settings of high disease transmission such as the Peruvian Amazon...
  56. Nalam K, Ahmed A, Devi S, Francalacci P, Baig M, Sechi L, et al. Genetic affinities within a large global collection of pathogenic Leptospira: implications for strain identification and molecular epidemiology. PLoS ONE. 2010;5:e12637 pubmed publisher
    ..The non-availability of accurate identification methods for the individualization of different Leptospira for outbreak investigations poses bountiful problems in the disease control arena...
  57. Miller M, Annis K, Lappin M, Lunn K. Variability in results of the microscopic agglutination test in dogs with clinical leptospirosis and dogs vaccinated against leptospirosis. J Vet Intern Med. 2011;25:426-32 pubmed publisher
    ..We sought to investigate the value of MAT results in predicting the infecting serogroup by comparing results across several laboratories and within individual dogs over time...
  58. Martins G, Penna B, Hamond C, Leite R, Silva A, Ferreira A, et al. Leptospirosis as the most frequent infectious disease impairing productivity in small ruminants in Rio de Janeiro, Brazil. Trop Anim Health Prod. 2012;44:773-7 pubmed publisher
    ..6% of goats and 3.2% of sheep samples were positive for CAE and MV, respectively. Leptospirosis was the major infectious problem in the small ruminants sampled and may contribute to impaired productivity of these animals...
  59. Hauk P, Barbosa A, Ho P, Farah C. Calcium binding to leptospira outer membrane antigen LipL32 is not necessary for its interaction with plasma fibronectin, collagen type IV, and plasminogen. J Biol Chem. 2012;287:4826-34 pubmed publisher
    LipL32 is the most abundant outer membrane protein from pathogenic Leptospira and has been shown to bind extracellular matrix (ECM) proteins as well as Ca(2+)...
  60. Smythe L, Adler B, Hartskeerl R, Galloway R, Turenne C, Levett P. Classification of Leptospira genomospecies 1, 3, 4 and 5 as Leptospira alstonii sp. nov., Leptospira vanthielii sp. nov., Leptospira terpstrae sp. nov. and Leptospira yanagawae sp. nov., respectively. Int J Syst Evol Microbiol. 2013;63:1859-62 pubmed publisher
    The genus Leptospira currently comprises 16 named species. In addition, four unnamed hybridization groups were designated Leptospira genomospecies 1, 3, 4 and 5...
  61. Slack A, Galloway R, Symonds M, Dohnt M, Smythe L. Reclassification of Leptospira meyeri serovar Perameles to Leptospira interrogans serovar Perameles through serological and molecular analysis: evidence of a need for changes to current procedures in Leptospira taxonomy. Int J Syst Evol Microbiol. 2009;59:1199-203 pubmed publisher
    It has been recognized that there is heterogeneity among Leptospira isolates in culture collections worldwide, causing confounding results for researchers utilizing these organisms; one such culture is Leptospira meyeri serovar Perameles...
  62. Chirathaworn C, Chantaramalai T, Sereemaspun A, Kongthong N, Suwancharoen D. Detection of Leptospira in urine using anti-Leptospira-coated gold nanoparticles. Comp Immunol Microbiol Infect Dis. 2011;34:31-4 pubmed publisher
    ..However, antibody is usually undetectable during the first week after infection. Detection of Leptospira DNA can be done by PCR but this technique requires special equipments and the cost is still relatively high...
  63. Rajeev S, Berghaus R, Overton M, Pence M, Baldwin C. Comparison of fluorescent antibody and microscopic agglutination testing for Leptospira in pregnant and nonpregnant cows. J Vet Diagn Invest. 2010;22:51-4 pubmed
    ..Four of the 7 herds that reported using a Leptospira borgpetersenii serovar Hardjo-bovis vaccine had one or more FAT-positive cows compared with 3 out of 3 herds ..
  64. Subharat S, Wilson P, Heuer C, Collins Emerson J. Investigation of localisation of Leptospira spp. in uterine and fetal tissues of non-pregnant and pregnant farmed deer. N Z Vet J. 2010;58:281-5 pubmed publisher
    To find evidence for localisation in the uterus, and fetal infection, of Leptospira spp. in farmed deer in the lower North Island of New Zealand during and shortly after the breeding season.
  65. Thaipadungpanit J, Thaipadunpanit J, Chierakul W, Wuthiekanun V, Limmathurotsakul D, Amornchai P, et al. Diagnostic accuracy of real-time PCR assays targeting 16S rRNA and lipL32 genes for human leptospirosis in Thailand: a case-control study. PLoS ONE. 2011;6:e16236 pubmed publisher
    ..The DSe of the rrs and lipL32 assays were high in the subgroup of 39 patients who were culture positive for Leptospira spp. (95% and 87%, respectively, p = 0.25)...
  66. Katz A, Buchholz A, Hinson K, Park S, Effler P. Leptospirosis in Hawaii, USA, 1999-2008. Emerg Infect Dis. 2011;17:221-6 pubmed publisher
    ..Also, during the past 20 years, recreational exposures have plateaued, while occupational exposures have increased. Ongoing surveillance is needed to clarify and track the dynamic epidemiology of this widespread zoonosis...
  67. Martins G, Brandão F, Hamond C, Medeiros M, Lilenbaum W. Diagnosis and control of an outbreak of leptospirosis in goats with reproductive failure. Vet J. 2012;193:600-1 pubmed publisher
    ..Soon after the outbreak, 61/125 (48.8%) of the goats were seropositive for Leptospira. Pure isolates of Leptospira were not obtained, but Leptospira PCR testing was positive in 48/50 (96%) urine ..
  68. Koizumi N, Nakajima C, Harunari T, Tanikawa T, Tokiwa T, Uchimura E, et al. A new loop-mediated isothermal amplification method for rapid, simple, and sensitive detection of Leptospira spp. in urine. J Clin Microbiol. 2012;50:2072-4 pubmed publisher
    ..a new loop-mediated isothermal amplification (LAMP) method to detect rrs, a 16S rRNA gene of pathogenic Leptospira spp. in urine...
  69. Desvars A, Naze F, Vourc h G, Cardinale E, Picardeau M, Michault A, et al. Similarities in Leptospira serogroup and species distribution in animals and humans in the Indian ocean island of Mayotte. Am J Trop Med Hyg. 2012;87:134-40 pubmed publisher
    Our objective was to identify local animal reservoirs of leptospirosis to explain the unusual features of Leptospira strains recently described among patients on the island of Mayotte...
  70. Fernandes L, Vieira M, Kirchgatter K, Alves I, de Morais Z, Vasconcellos S, et al. OmpL1 is an extracellular matrix- and plasminogen-interacting protein of Leptospira spp. Infect Immun. 2012;80:3679-92 pubmed publisher
    Leptospirosis is a zoonosis with multisystem involvement caused by pathogenic strains of the genus Leptospira. OmpL1 is an outer membrane protein of Leptospira spp. that is expressed during infection...
  71. Stoddard R. Detection of pathogenic Leptospira spp. through real-time PCR (qPCR) targeting the LipL32 gene. Methods Mol Biol. 2013;943:257-66 pubmed publisher
    ..There are a limited number of real-time PCR (qPCR) assays for detecting Leptospira and not all of these assays are able to distinguish pathogenic from nonpathogenic species...
  72. Stoddard R, Gee J, Wilkins P, McCaustland K, Hoffmaster A. Detection of pathogenic Leptospira spp. through TaqMan polymerase chain reaction targeting the LipL32 gene. Diagn Microbiol Infect Dis. 2009;64:247-55 pubmed publisher
    ..polymerase chain reaction (PCR) assay using a TaqMan probe targeting lipL32, which is present only in pathogenic Leptospira spp...
  73. Agudelo Florez P, Londoño A, Quiroz V, Angel J, Moreno N, Loaiza E, et al. Prevalence of Leptospira spp. in urban rodents from a groceries trade center of Medellin, Colombia. Am J Trop Med Hyg. 2009;81:906-10 pubmed publisher
    ..Our goal was to determine the frequency for Leptospira infection in rodents in a farmers market in the city of Medellin...
  74. Stern E, Galloway R, Shadomy S, Wannemuehler K, Atrubin D, Blackmore C, et al. Outbreak of leptospirosis among Adventure Race participants in Florida, 2005. Clin Infect Dis. 2010;50:843-9 pubmed publisher
    ..On 21 November 2005, a 32-year-old male resident of New York was hospitalized with suspected leptospirosis. He had participated in an endurance-length swamp race on 4-5 November 2005 outside of Tampa, Florida...
  75. Ahmed A, Anthony R, Hartskeerl R. A simple and rapid molecular method for Leptospira species identification. Infect Genet Evol. 2010;10:955-62 pubmed publisher
    ..Currently serological and molecular methods for characterizing Leptospira are complex and costly restricting their world-wide distribution and use...
  76. Evangelista K, Coburn J. Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses. Future Microbiol. 2010;5:1413-25 pubmed publisher
    ..Several pathogenic species of the genus Leptospira can cause a wide range of clinical manifestations, from a mild, flu-like illness to a severe disease form ..
  77. Goris M, Wagenaar J, Hartskeerl R, van Gorp E, Schuller S, Monahan A, et al. Potent innate immune response to pathogenic leptospira in human whole blood. PLoS ONE. 2011;6:e18279 pubmed publisher
    Leptospirosis is caused by pathogenic spirochetes of the genus Leptospira. The bacteria enter the human body via abraded skin or mucous membranes and may disseminate throughout...
  78. Perez J, Brescia F, Becam J, Mauron C, Goarant C. Rodent abundance dynamics and leptospirosis carriage in an area of hyper-endemicity in New Caledonia. PLoS Negl Trop Dis. 2011;5:e1361 pubmed publisher
    ..A better knowledge of how rodent populations and their Leptospira prevalence respond to seasonal and meteorological fluctuations might help implement relevant control measures.
  79. Benacer D, Woh P, Mohd Zain S, Amran F, Thong K. Pathogenic and saprophytic Leptospira species in water and soils from selected urban sites in peninsular Malaysia. Microbes Environ. 2013;28:135-40 pubmed
    b>Leptospira species were studied in water and soils from selected urban sites in Malaysia. A total of 151 water (n=121) and soil (n=30) samples were collected from 12 recreational lakes and wet markets...
  80. Cerqueira G, Picardeau M. A century of Leptospira strain typing. Infect Genet Evol. 2009;9:760-8 pubmed publisher
    ..Since the discovery of Leptospira, the causal agent of leptospirosis, a century ago, this spirochete has been isolated from the environment and a ..
  81. Vedhagiri K, Natarajaseenivasan K, Chellapandi P, Prabhakaran S, Selvin J, Sharma S, et al. Evolutionary implication of outer membrane lipoprotein-encoding genes ompL1, UpL32 and lipL41 of pathogenic Leptospira species. Genomics Proteomics Bioinformatics. 2009;7:96-106 pubmed publisher
    ..In this study, the antigenic variation in Leptospira interrogans and Leptospira borgpetersenii isolated from human urine and field rat kidney was preliminarily ..
  82. Araujo E, Seguro A, Spichler A, Magaldi A, Volpini R, de Brito T. Acute kidney injury in human leptospirosis: an immunohistochemical study with pathophysiological correlation. Virchows Arch. 2010;456:367-75 pubmed publisher
    ..Enhanced expression of aquaporin 2 in medullary collecting tubules is probably an attempt to retain water during the nonoliguric phase of renal failure...
  83. Rojas P, Monahan A, Schuller S, Miller I, Markey B, Nally J. Detection and quantification of leptospires in urine of dogs: a maintenance host for the zoonotic disease leptospirosis. Eur J Clin Microbiol Infect Dis. 2010;29:1305-9 pubmed publisher
    Leptospirosis is a global zoonotic disease. Pathogenic Leptospira species, the causative agent of leptospirosis, colonize the renal tubules of chronically infected maintenance hosts such as dogs, rats and cattle...
  84. Tulsiani S, Lau C, Graham G, Van Den Hurk A, Jansen C, Smythe L, et al. Emerging tropical diseases in Australia. Part 1. Leptospirosis. Ann Trop Med Parasitol. 2010;104:543-56 pubmed publisher
    ..This information should furnish clinicians with an updated tool to help overcome a number of problems associated with the diagnosis of leptospirosis...
  85. Cerqueira G, McBride A, Hartskeerl R, Ahmed N, Dellagostin O, Eslabão M, et al. Bioinformatics describes novel Loci for high resolution discrimination of leptospira isolates. PLoS ONE. 2010;5:e15335 pubmed publisher
    ..The development of multilocus sequence typing (MLST) schemes for Leptospira spp. is addressing this issue...
  86. Raman R, Rajanikanth V, Palaniappan R, Lin Y, He H, McDonough S, et al. Big domains are novel Ca²+-binding modules: evidences from big domains of Leptospira immunoglobulin-like (Lig) proteins. PLoS ONE. 2010;5:e14377 pubmed publisher
    ..Based on the possible similarities of immunoglobulin and ??-crystallin folds, we here explore the important question whether Ca²+ binds to a Big domains, which would provide a novel functional role of the proteins containing Big fold...
  87. Midence J, Leutenegger C, Chandler A, Goldstein R. Effects of recent Leptospira vaccination on whole blood real-time PCR testing in healthy client-owned dogs. J Vet Intern Med. 2012;26:149-52 pubmed publisher
    Bacterin-based canine Leptospira vaccines could present a challenge for the use of whole blood real-time polymerase chain reaction (PCR) as a diagnostic tool...
  88. Jorge S, Monte L, Coimbra M, Albano A, Hartwig D, Lucas C, et al. Detection of virulence factors and molecular typing of pathogenic Leptospira from capybara (Hydrochaeris hydrochaeris). Curr Microbiol. 2012;65:461-4 pubmed publisher
    Leptospirosis is a globally prevalent zoonosis caused by pathogenic Leptospira spp.; several serologic variants have reservoirs in synanthropic rodents...
  89. Chou L, Chen Y, Lu C, Ko Y, Tang C, Pan M, et al. Sequence of Leptospira santarosai serovar Shermani genome and prediction of virulence-associated genes. Gene. 2012;511:364-70 pubmed publisher
    Leptospirosis, a widespread zoonosis, is a re-emerging infectious disease caused by pathogenic Leptospira species...
  90. Picardeau M. Diagnosis and epidemiology of leptospirosis. Med Mal Infect. 2013;43:1-9 pubmed publisher
    ..Leptospirosis is expected to become more important due to a rapid urbanization in developing countries (slums), global warming, and extreme climatic events (floods)...
  91. Tung J, Yang C, Chou S, Lin C, Sun Y. Calcium binds to LipL32, a lipoprotein from pathogenic Leptospira, and modulates fibronectin binding. J Biol Chem. 2010;285:3245-52 pubmed publisher
    ..LipL32, a major lipoprotein and a virulence factor, locates on the outer membrane of the pathogen Leptospira. It evades immune response by recognizing and adhering to extracellular matrix components of the host cell...
  92. Fenner J, Anjum M, Randall L, Pritchard G, Wu G, Errington J, et al. Analysis of 16S rDNA sequences from pathogenic Leptospira serovars and use of single nucleotide polymorphisms for rapid speciation by D-HPLC. Res Vet Sci. 2010;89:48-57 pubmed publisher
    b>Leptospira have a worldwide distribution and include important zoonotic pathogens yet diagnosis and differentiation still tend to rely on traditional bacteriological and serological approaches. In this study a 1...