francisella tularensis

Summary

Summary: The etiologic agent of TULAREMIA in man and other warm-blooded animals.

Top Publications

  1. Kuolee R, Harris G, Conlan J, Chen W. Role of neutrophils and NADPH phagocyte oxidase in host defense against respiratory infection with virulent Francisella tularensis in mice. Microbes Infect. 2011;13:447-56 pubmed publisher
    b>Francisella tularensis subspecies (subsp.) tularensis is a CDC Category A biological warfare agent and inhalation of as few as 15 bacilli can initiate severe disease...
  2. Al Khodor S, Abu Kwaik Y. Triggering Ras signalling by intracellular Francisella tularensis through recruitment of PKC? and ?I to the SOS2/GrB2 complex is essential for bacterial proliferation in the cytosol. Cell Microbiol. 2010;12:1604-21 pubmed publisher
    Intracellular proliferation of Francisella tularensis is essential for manifestation of the fatal disease tularaemia, and is classified as a category A bioterrorism agent. The F...
  3. Peng K, Monack D. Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs. Infect Immun. 2010;78:2723-33 pubmed publisher
    ..b>Francisella tularensis is a bacterium capable of infecting multiple organs and thus encounters a myriad of organ-specific defense ..
  4. Leander R, Dai S, Schlesinger L, Friedman A. A mathematical model of CR3/TLR2 crosstalk in the context of Francisella tularensis infection. PLoS Comput Biol. 2012;8:e1002757 pubmed publisher
    ..Recognition of the virulent Schu S4 strain of the intracellular pathogen Francisella tularensis by host macrophages involves CR3/TLR2 crosstalk...
  5. Triebenbach A, Vogl S, Lotspeich Cole L, Sikes D, Happ G, Hueffer K. Detection of Francisella tularensis in Alaskan mosquitoes (Diptera: Culicidae) and assessment of a laboratory model for transmission. J Med Entomol. 2010;47:639-48 pubmed
    Tularemia is a zoonotic disease caused by the Category A bioterrorism agent Francisella tularensis. In Scandinavia, tularemia transmission by mosquitoes has been widely cited in the literature...
  6. Deshpande A, Gans J, Graves S, Green L, Taylor L, Kim H, et al. A rapid multiplex assay for nucleic acid-based diagnostics. J Microbiol Methods. 2010;80:155-63 pubmed publisher
    ..anthracis, Y. pestis, and F. tularensis. Combined with the ease and robustness of this assay, the results presented here show a strong potential of our assay for use in diagnostics and surveillance. ..
  7. Gestin B, Valade E, Thibault F, Schneider D, Maurin M. Phenotypic and genetic characterization of macrolide resistance in Francisella tularensis subsp. holarctica biovar I. J Antimicrob Chemother. 2010;65:2359-67 pubmed publisher
    b>Francisella tularensis subsp. holarctica strains are classified as biovars I and II, which are susceptible and naturally resistant to the macrolide erythromycin, respectively...
  8. Pyles R, Jezek G, Eaves Pyles T. Toll-like receptor 3 agonist protection against experimental Francisella tularensis respiratory tract infection. Infect Immun. 2010;78:1700-10 pubmed publisher
    We investigated whether Toll-like receptor 3 (TLR3) stimulation would protect the host from inhaled Francisella tularensis. TLR3 is expressed by respiratory epithelial cells and macrophages and can be activated by a synthetic double-..
  9. Jia Q, Lee B, Bowen R, Dillon B, Som S, Horwitz M. A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis chall. Infect Immun. 2010;78:4341-55 pubmed publisher
    b>Francisella tularensis, the causative agent of tularemia, is in the top category (category A) of potential agents of bioterrorism. The F...

More Information

Publications110 found, 100 shown here

  1. Zhao J, Raetz C. A two-component Kdo hydrolase in the inner membrane of Francisella novicida. Mol Microbiol. 2010;78:820-36 pubmed publisher
    Lipid A coats the outer surface of the outer membrane of Gram-negative bacteria. In Francisella tularensis subspecies novicida lipid A is present either as the covalently attached anchor of lipopolysaccharide (LPS) or as free lipid A...
  2. Mahawar M, Atianand M, Dotson R, Mora V, Rabadi S, Metzger D, et al. Identification of a novel Francisella tularensis factor required for intramacrophage survival and subversion of innate immune response. J Biol Chem. 2012;287:25216-29 pubmed publisher
    b>Francisella tularensis, the causative agent of tularemia, is one of the deadliest agents of biological warfare and bioterrorism...
  3. Crane D, Ireland R, Alinger J, Small P, Bosio C. Lipids derived from virulent Francisella tularensis broadly inhibit pulmonary inflammation via toll-like receptor 2 and peroxisome proliferator-activated receptor ?. Clin Vaccine Immunol. 2013;20:1531-40 pubmed publisher
    b>Francisella tularensis is a Gram-negative facultative intracellular pathogen that causes an acute lethal respiratory disease in humans...
  4. Janse I, Hamidjaja R, Bok J, van Rotterdam B. Reliable detection of Bacillus anthracis, Francisella tularensis and Yersinia pestis by using multiplex qPCR including internal controls for nucleic acid extraction and amplification. BMC Microbiol. 2010;10:314 pubmed publisher
    ..The application of B. thuringiensis spores as internal controls further reduces false negative results. This ensures highly reliable detection, while template consumption and laboratory effort are kept at a minimum. ..
  5. Skyberg J, Rollins M, Holderness J, Marlenee N, Schepetkin I, Goodyear A, et al. Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections. PLoS Pathog. 2012;8:e1002587 pubmed publisher
    Pulmonary Francisella tularensis and Burkholderia pseudomallei infections are highly lethal in untreated patients, and current antibiotic regimens are not always effective...
  6. Mohapatra N, Soni S, Rajaram M, Strandberg K, Gunn J. Type A Francisella tularensis acid phosphatases contribute to pathogenesis. PLoS ONE. 2013;8:e56834 pubmed publisher
    ..Thus, F. tularensis Schu S4 acid phosphatases, including the truncated HapA, play a major role in intramacrophage survival and virulence of this human pathogen. ..
  7. Cremer T, Ravneberg D, Clay C, Piper Hunter M, Marsh C, Elton T, et al. MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS ONE. 2009;4:e8508 pubmed publisher
    The intracellular gram-negative bacterium Francisella tularensis causes the disease tularemia and is known for its ability to subvert host immune responses...
  8. Kubelkova K, Krocova Z, Balonova L, Pejchal J, Stulik J, Macela A. Specific antibodies protect gamma-irradiated mice against Francisella tularensis infection. Microb Pathog. 2012;53:259-68 pubmed publisher
    The role of antibodies in the course of Francisella tularensis (F. tularensis) infection is still a subject of debate...
  9. Skyberg J, Rollins M, Samuel J, Sutherland M, Belisle J, Pascual D. Interleukin-17 protects against the Francisella tularensis live vaccine strain but not against a virulent F. tularensis type A strain. Infect Immun. 2013;81:3099-105 pubmed publisher
    b>Francisella tularensis is a highly infectious intracellular bacterium that causes the zoonotic infection tularemia. While much literature exists on the host response to F...
  10. Bandara A, Champion A, Wang X, Berg G, Apicella M, McLendon M, et al. Isolation and mutagenesis of a capsule-like complex (CLC) from Francisella tularensis, and contribution of the CLC to F. tularensis virulence in mice. PLoS ONE. 2011;6:e19003 pubmed publisher
    b>Francisella tularensis is a category-A select agent and is responsible for tularemia in humans and animals. The surface components of F. tularensis that contribute to virulence are not well characterized...
  11. Forslund A, Salomonsson E, Golovliov I, Kuoppa K, Michell S, Titball R, et al. The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis. BMC Microbiol. 2010;10:227 pubmed publisher
    All four Francisella tularensis subspecies possess gene clusters with potential to express type IV pili (Tfp). These clusters include putative pilin genes, as well as pilB, pilC and pilQ, required for secretion and assembly of Tfp...
  12. Loveless B, Yermakova A, Christensen D, Kondig J, Heine H, Wasieloski L, et al. Identification of ciprofloxacin resistance by SimpleProbe, High Resolution Melt and Pyrosequencing nucleic acid analysis in biothreat agents: Bacillus anthracis, Yersinia pestis and Francisella tularensis. Mol Cell Probes. 2010;24:154-60 pubmed publisher
    ..Ciprofloxacin-resistant (cipro(r)) strains of Bacillus anthracis, Yersinia pestis, and Francisella tularensis with one or more known mutations within the QRDR of gyrA, gyrB, parC, and parE genes were tested with ..
  13. Lindgren M, Bröms J, Meyer L, Golovliov I, Sjostedt A. The Francisella tularensis LVS ?pdpC mutant exhibits a unique phenotype during intracellular infection. BMC Microbiol. 2013;13:20 pubmed publisher
    A prerequisite for the virulence of the facultative intracellular bacterium Francisella tularensis is effective intramacrophage proliferation, which is preceded by phagosomal escape into the cytosol, and ultimately leads to host cell ..
  14. Wrench A, Gardner C, Gonzalez C, Lorca G. Identification of a small molecule that modifies MglA/SspA interaction and impairs intramacrophage survival of Francisella tularensis. PLoS ONE. 2013;8:e54498 pubmed publisher
    The transcription factors MglA and SspA of Francisella tularensis form a heterodimer complex and interact with the RNA polymerase to regulate the expression of the Francisella pathogenicity island (FPI) genes...
  15. Seibold E, Maier T, Kostrzewa M, Zeman E, Splettstoesser W. Identification of Francisella tularensis by whole-cell matrix-assisted laser desorption ionization-time of flight mass spectrometry: fast, reliable, robust, and cost-effective differentiation on species and subspecies levels. J Clin Microbiol. 2010;48:1061-9 pubmed publisher
    b>Francisella tularensis, the causative agent of tularemia, is a potential agent of bioterrorism...
  16. Kim T, Sebastian S, Pinkham J, ROSS R, Blalock L, Kasper D. Characterization of the O-antigen polymerase (Wzy) of Francisella tularensis. J Biol Chem. 2010;285:27839-49 pubmed publisher
    ..annotated as the putative O-antigen polymerase, which is located in the O-antigen biosynthetic locus of Francisella tularensis. In silico analysis (homology searching, hydropathy plotting, and codon usage assessment) strongly ..
  17. Hickey A, Hazlett K, Kirimanjeswara G, Metzger D. Identification of Francisella tularensis outer membrane protein A (FopA) as a protective antigen for tularemia. Vaccine. 2011;29:6941-7 pubmed publisher
    b>Francisella tularensis is a highly pathogenic gram negative bacterium that infects multiple sites in a host, including the skin and the respiratory tract, which can lead to the onset of a deadly disease with a 50% mortality rate...
  18. Kingry L, Troyer R, Marlenee N, Bielefeldt Ohmann H, Bowen R, Schenkel A, et al. Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis. Microbes Infect. 2011;13:261-75 pubmed publisher
    b>Francisella tularensis is a category A select agent based on its infectivity and virulence but disease mechanisms in infection remain poorly understood...
  19. Eneslätt K, Rietz C, Ryden P, Stoven S, House R, Wolfraim L, et al. Persistence of cell-mediated immunity three decades after vaccination with the live vaccine strain of Francisella tularensis. Eur J Immunol. 2011;41:974-80 pubmed publisher
    ..The causative agent of tularemia, Francisella tularensis, is rare in most areas and, therefore, tularemia vaccination is an interesting model for studies of the ..
  20. Ryden P, Twine S, Shen H, Harris G, Chen W, Sjostedt A, et al. Correlates of protection following vaccination of mice with gene deletion mutants of Francisella tularensis subspecies tularensis strain, SCHU S4 that elicit varying degrees of immunity to systemic and respiratory challenge with wild-type bacteria. Mol Immunol. 2013;54:58-67 pubmed publisher
    b>Francisella tularensis subspecies tularensis is an extremely virulent facultative intracellular bacterial pathogen capable of causing significant mortality in humans when inhaled...
  21. Russo B, Brown M, Nau G. MyD88-dependent signaling prolongs survival and reduces bacterial burden during pulmonary infection with virulent Francisella tularensis. Am J Pathol. 2013;183:1223-1232 pubmed publisher
    b>Francisella tularensis is the causative agent of the debilitating febrile illness tularemia. The severe morbidity associated with F. tularensis infections is attributed to its ability to evade the host immune response...
  22. Pilo P, Johansson A, Frey J. Identification of Francisella tularensis cluster in central and western Europe. Emerg Infect Dis. 2009;15:2049-51 pubmed publisher
    We conducted a molecular analysis of Francisella tularensis strains isolated in Switzerland and identified a specific subpopulation belonging to a cluster of F. tularensis subsp...
  23. Ray H, Chu P, Wu T, Lyons C, Murthy A, Guentzel M, et al. The Fischer 344 rat reflects human susceptibility to francisella pulmonary challenge and provides a new platform for virulence and protection studies. PLoS ONE. 2010;5:e9952 pubmed publisher
    The pathogenesis of Francisella tularensis, the causative agent of tularemia, has been primarily characterized in mice...
  24. Busse H, Huber B, Anda P, Escudero R, Scholz H, Seibold E, et al. Objections to the transfer of Francisella novicida to the subspecies rank of Francisella tularensis - response to Johansson et al. Int J Syst Evol Microbiol. 2010;60:1718-20 pubmed
  25. Sen B, Meeker A, Ramakrishnan G. The fslE homolog, FTL_0439 (fupA/B), mediates siderophore-dependent iron uptake in Francisella tularensis LVS. Infect Immun. 2010;78:4276-85 pubmed publisher
    The Gram-negative pathogen Francisella tularensis secretes a siderophore to obtain essential iron by a TonB-independent mechanism...
  26. Thomas R, Twine S, Fulton K, Tessier L, Kilmury S, Ding W, et al. Glycosylation of DsbA in Francisella tularensis subsp. tularensis. J Bacteriol. 2011;193:5498-509 pubmed publisher
    In Francisella tularensis subsp. tularensis, DsbA has been shown to be an essential virulence factor and has been observed to migrate to multiple protein spots on two-dimensional electrophoresis gels...
  27. Geier H, Celli J. Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis. Infect Immun. 2011;79:2204-14 pubmed publisher
    b>Francisella tularensis, the causative agent of tularemia, survives and proliferates within macrophages of the infected host as part of its pathogenic strategy, through an intracellular life cycle that includes phagosomal escape and ..
  28. Karlsson E, Svensson K, Lindgren P, Bystrom M, Sjodin A, Forsman M, et al. The phylogeographic pattern of Francisella tularensis in Sweden indicates a Scandinavian origin of Eurosiberian tularaemia. Environ Microbiol. 2013;15:634-45 pubmed publisher
    Previous studies of the causative agent of tularaemia, Francisella tularensis have identified phylogeographic patterns suggestive of environmental maintenance reservoirs...
  29. Thomas Charles C, Zheng H, Palmer L, Mena P, Thanassi D, Furie M. FeoB-mediated uptake of iron by Francisella tularensis. Infect Immun. 2013;81:2828-37 pubmed publisher
    b>Francisella tularensis, the bacterial cause of tularemia, infects the liver and replicates in hepatocytes in vivo and in vitro. However, the factors that govern adaptation of F...
  30. Furuya Y, Kirimanjeswara G, Roberts S, Metzger D. Increased susceptibility of IgA-deficient mice to pulmonary Francisella tularensis live vaccine strain infection. Infect Immun. 2013;81:3434-41 pubmed publisher
    b>Francisella tularensis, the causative agent of tularemia, is most deadly in the pneumonic form; therefore, mucosal immunity is an important first line of defense against this pathogen. We have now evaluated the lethality of primary F...
  31. Zarrella T, Singh A, Bitsaktsis C, Rahman T, Sahay B, Feustel P, et al. Host-adaptation of Francisella tularensis alters the bacterium's surface-carbohydrates to hinder effectors of innate and adaptive immunity. PLoS ONE. 2011;6:e22335 pubmed publisher
    The gram-negative bacterium Francisella tularensis survives in arthropods, fresh water amoeba, and mammals with both intracellular and extracellular phases and could reasonably be expected to express distinct phenotypes in these ..
  32. Schunder E, Rydzewski K, Grunow R, Heuner K. First indication for a functional CRISPR/Cas system in Francisella tularensis. Int J Med Microbiol. 2013;303:51-60 pubmed publisher
    b>Francisella tularensis is a zoonotic agent and the subspecies novicida is proposed to be a water-associated bacterium. The intracellular pathogen F...
  33. Lundstrom J, Andersson A, Backman S, Schafer M, Forsman M, Thelaus J. Transstadial transmission of Francisella tularensis holarctica in mosquitoes, Sweden. Emerg Infect Dis. 2011;17:794-9 pubmed publisher
    In Sweden, human cases of tularemia caused by Francisella tularensis holarctica are assumed to be transmitted by mosquitoes, but how mosquito vectors acquire and transmit the bacterium is not clear...
  34. Martinon F, Chen X, Lee A, Glimcher L. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol. 2010;11:411-8 pubmed publisher
    ..resulted in a much greater bacterial burden in mice infected with the TLR2-activating human intracellular pathogen Francisella tularensis. Our findings identify an unsuspected critical function for XBP1 in mammalian host defenses.
  35. Khader S, Gopal R. IL-17 in protective immunity to intracellular pathogens. Virulence. 2010;1:423-7 pubmed publisher
    ..The current outlook on the role of IL-23-IL-17 pathway in protective immunity to intracellular pathogens is discussed here...
  36. Moniuszko A, Zajkowska J, Pancewicz S, Kondrusik M, Grygorczuk S, Czupryna P. Arthropod-borne tularemia in Poland: a case report. Vector Borne Zoonotic Dis. 2011;11:1399-401 pubmed publisher
    ..In our article, we present the case of a patient who was infected with Francisella tularensis due to arthropod bite...
  37. Horzempa J, O Dee D, Stolz D, Franks J, Clay D, Nau G. Invasion of erythrocytes by Francisella tularensis. J Infect Dis. 2011;204:51-9 pubmed publisher
    b>Francisella tularensis is the causative agent of tularemia and is classified as a category A biodefense agent by the Centers for Disease Control and Prevention because of its highly infectious nature. F...
  38. Asare R, Abu Kwaik Y. Molecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensis. Environ Microbiol. 2010;12:2559-86 pubmed publisher
    Upon entry of Francisella tularensis to macrophages, the Francisella-containing phagosome (FCP) is trafficked into an acidified late endosome-like phagosome with limited fusion to the lysosomes followed by rapid escape into the cytosol ..
  39. Vogler A, Birdsell D, Lee J, Vaissaire J, Doujet C, Lapalus M, et al. Phylogeography of Francisella tularensis ssp. holarctica in France. Lett Appl Microbiol. 2011;52:177-80 pubmed publisher
    To investigate the phylogeography of French Francisella tularensis ssp. holarctica isolates. ? Canonical SNPs and MLVA were used to genotype 103 French F. tularensis ssp. holarctica isolates...
  40. Santic M, Pavokovic G, Jones S, Asare R, Kwaik Y. Regulation of apoptosis and anti-apoptosis signalling by Francisella tularensis. Microbes Infect. 2010;12:126-34 pubmed publisher
    b>Francisella tularensis induces apoptosis within macrophages but the temporal and spatial modulation through activation of caspase-1, caspase-3, and the anti-apoptosis nuclear transcription factor B (NF-kappaB) is not known...
  41. Yu J, Goluguri T, Guentzel M, Chambers J, Murthy A, Klose K, et al. Francisella tularensis T-cell antigen identification using humanized HLA-DR4 transgenic mice. Clin Vaccine Immunol. 2010;17:215-22 pubmed publisher
    There is no licensed vaccine against the intracellular pathogen Francisella tularensis. The use of conventional mouse strains to screen protective vaccine antigens may be problematic, given the differences in the major histocompatibility ..
  42. Nalbantoglu U, Sayood K, Dempsey M, Iwen P, Francesconi S, Barabote R, et al. Large direct repeats flank genomic rearrangements between a new clinical isolate of Francisella tularensis subsp. tularensis A1 and Schu S4. PLoS ONE. 2010;5:e9007 pubmed publisher
    b>Francisella tularensis subspecies tularensis consists of two separate populations A1 and A2. This report describes the complete genome sequence of NE061598, an F...
  43. Gyuranecz M, Denes B, Dan A, Rigó K, Földvári G, Szeredi L, et al. Susceptibility of the common hamster (Cricetus cricetus) to Francisella tularensis and its effect on the epizootiology of tularemia in an area where both are endemic. J Wildl Dis. 2010;46:1316-20 pubmed
    b>Francisella tularensis is a highly infectious zoonotic agent causing the disease tularemia. The common hamster (Cricetus cricetus) is considered a pest in eastern Europe, and believed to be a source of human tularemia infections...
  44. Medina E, Morris I, Berton M. Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain. J Immunol. 2010;185:7562-72 pubmed publisher
    An inadequate innate immune response appears to contribute to the virulence of Francisella tularensis following pulmonary infection...
  45. De Pascalis R, Chou A, Bosio C, Huang C, Follmann D, Elkins K. Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS. PLoS Pathog. 2012;8:e1002494 pubmed publisher
    ..to explore development of clinically useful correlates of protection for intracellular bacteria, using Francisella tularensis as an experimental model. F...
  46. Kleo K, Schafer D, Klar S, Jacob D, Grunow R, Lisdat F. Immunodetection of inactivated Francisella tularensis bacteria by using a quartz crystal microbalance with dissipation monitoring. Anal Bioanal Chem. 2012;404:843-51 pubmed publisher
    b>Francisella tularensis are very small, gram-negative bacteria which are capable of infecting a number of mammals. As a highly pathogenic species, it is a potential bioterrorism agent...
  47. Barel M, Meibom K, Dubail I, Botella J, Charbit A. Francisella tularensis regulates the expression of the amino acid transporter SLC1A5 in infected THP-1 human monocytes. Cell Microbiol. 2012;14:1769-83 pubmed publisher
    b>Francisella tularensis, a Gram-negative bacterium that causes the disease tularemia in a large number of animal species, is thought to reside preferentially within macrophages in vivo. F...
  48. Kurtz S, Foreman O, Bosio C, Anver M, Elkins K. Interleukin-6 is essential for primary resistance to Francisella tularensis live vaccine strain infection. Infect Immun. 2013;81:585-97 pubmed publisher
    We employed Francisella tularensis live vaccine strain (LVS) to study mechanisms of protective immunity against intracellular pathogens and, specifically, to understand protective correlates...
  49. Margolis J, El Etr S, Joubert L, Moore E, Robison R, Rasley A, et al. Contributions of Francisella tularensis subsp. novicida chitinases and Sec secretion system to biofilm formation on chitin. Appl Environ Microbiol. 2010;76:596-608 pubmed publisher
    b>Francisella tularensis, the zoonotic cause of tularemia, can infect numerous mammals and other eukaryotes. Although studying F...
  50. Nelson M, Lever M, Dean R, Savage V, Salguero F, Pearce P, et al. Characterization of lethal inhalational infection with Francisella tularensis in the common marmoset (Callithrix jacchus). J Med Microbiol. 2010;59:1107-13 pubmed publisher
    The intracellular Gram-negative pathogen Francisella tularensis is the causative agent of tularaemia and is prevalent in many countries in the northern hemisphere...
  51. Goethert H, Telford S. Differential mortality of dog tick vectors due to infection by diverse Francisella tularensis tularensis genotypes. Vector Borne Zoonotic Dis. 2011;11:1263-8 pubmed publisher
    The factors involved in the long-term perpetuation of Francisella tularensis tularensis in nature are poorly understood...
  52. Straskova A, Cerveny L, Spidlová P, Dankova V, Belcic D, Santic M, et al. Deletion of IglH in virulent Francisella tularensis subsp. holarctica FSC200 strain results in attenuation and provides protection against the challenge with the parental strain. Microbes Infect. 2012;14:177-87 pubmed publisher
    b>Francisella tularensis, the causative agent of tularemia, is a highly infectious intracellular pathogen with no licensed vaccine available today. The recent search for genome sequences involved in F...
  53. Qin A, Scott D, Rabideau M, Moore E, Mann B. Requirement of the CXXC motif of novel Francisella infectivity potentiator protein B FipB, and FipA in virulence of F. tularensis subsp. tularensis. PLoS ONE. 2011;6:e24611 pubmed publisher
    The lipoprotein encoded by the Francisella tularensis subsp...
  54. Schmitt D, O Dee D, Horzempa J, Carlson P, Russo B, Bales J, et al. A Francisella tularensis live vaccine strain that improves stimulation of antigen-presenting cells does not enhance vaccine efficacy. PLoS ONE. 2012;7:e31172 pubmed publisher
    ..The tularemia vaccine, Francisella tularensis live vaccine strain (LVS), does not elicit complete protection against lethal challenge with a virulent ..
  55. Rotem S, Bar Haim E, Cohen H, Elia U, Ber R, Shafferman A, et al. Consequences of delayed ciprofloxacin and doxycycline treatment regimens against Francisella tularensis airway infection. Antimicrob Agents Chemother. 2012;56:5406-8 pubmed publisher
    ..of extensively delayed ciprofloxacin or doxycycline treatments following airway exposure of mice to Francisella tularensis subsp. holarctica (strain LVS) or to the highly virulent F. tularensis subsp. tularensis (strain SchuS4)...
  56. Molins C, Delorey M, Young J, Yockey B, Belisle J, Schriefer M, et al. Use of temperature for standardizing the progression of Francisella tularensis in mice. PLoS ONE. 2012;7:e45310 pubmed publisher
    ..temperature as a non-subjective measurement to follow and compare infection in mice inoculated with Francisella tularensis, a Gram-negative pathogen that produces an acute and fatal illness in mice...
  57. Faith S, Smith L, Swatland A, Reed D. Growth conditions and environmental factors impact aerosolization but not virulence of Francisella tularensis infection in mice. Front Cell Infect Microbiol. 2012;2:126 pubmed publisher
    In refining methodology to develop a mouse model for inhalation of Francisella tularensis, it was noted that both relative humidity and growth media impacted the aerosol concentration of the live vaccine strain (LVS) of F. tularensis...
  58. Muller W, Hotzel H, Otto P, Karger A, Bettin B, Bocklisch H, et al. German Francisella tularensis isolates from European brown hares (Lepus europaeus) reveal genetic and phenotypic diversity. BMC Microbiol. 2013;13:61 pubmed publisher
    Tularemia is a zoonotic disease caused by Francisella tularensis that has been found in many different vertebrates. In Germany most human infections are caused by contact with infected European brown hares (Lepus europaeus)...
  59. Faron M, Fletcher J, Rasmussen J, Long M, Allen L, Jones B. The Francisella tularensis migR, trmE, and cphA genes contribute to F. tularensis pathogenicity island gene regulation and intracellular growth by modulation of the stress alarmone ppGpp. Infect Immun. 2013;81:2800-11 pubmed publisher
    The Francisella tularensis pathogenicity island (FPI) encodes many proteins that are required for virulence...
  60. McCaffrey R, Schwartz J, Lindemann S, Moreland J, Buchan B, Jones B, et al. Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis. J Leukoc Biol. 2010;88:791-805 pubmed publisher
    ..As Ft uses multiple mechanisms to block neutrophil NADPH oxidase activity, our data strongly suggest that this is a central aspect of virulence...
  61. Paranavitana C, Zelazowska E, DaSilva L, Pittman P, Nikolich M. Th17 cytokines in recall responses against Francisella tularensis in humans. J Interferon Cytokine Res. 2010;30:471-6 pubmed publisher
    ..species, we investigated production of Th17-associated cytokines IL-17 and IL-22 in a recall response to Francisella tularensis. Peripheral blood mononuclear cells (PBMCs) from volunteers previously immunized with the F...
  62. Reese S, Dietrich G, Dolan M, Sheldon S, Piesman J, Petersen J, et al. Transmission dynamics of Francisella tularensis subspecies and clades by nymphal Dermacentor variabilis (Acari: Ixodidae). Am J Trop Med Hyg. 2010;83:645-52 pubmed publisher
    ..the American dog tick, Dermacentor variabilis (Say) is considered an important biological vector of Francisella tularensis, the etiologic agent of tularemia. In this study, we evaluated the vector efficiency of nymphal D...
  63. Lindgren M, Eneslätt K, Bröms J, Sjostedt A. Importance of PdpC, IglC, IglI, and IglG for modulation of a host cell death pathway induced by Francisella tularensis. Infect Immun. 2013;81:2076-84 pubmed publisher
    ..The facultative intracellular bacterium Francisella tularensis is highly pathogenic, and effective proliferation in the macrophage cytosol leading to host cell death is ..
  64. Walters K, Olsufka R, Kuestner R, Cho J, Li H, Zornetzer G, et al. Francisella tularensis subsp. tularensis induces a unique pulmonary inflammatory response: role of bacterial gene expression in temporal regulation of host defense responses. PLoS ONE. 2013;8:e62412 pubmed publisher
    Pulmonary exposure to Francisella tularensis is associated with severe lung pathology and a high mortality rate...
  65. Su S, Saldanha R, Pemberton A, Bangar H, Kawamoto S, Aronow B, et al. Characterization of stable, constitutively expressed, chromosomal green and red fluorescent transcriptional fusions in the select agent bacterium, Francisella tularensis Schu S4 and the surrogate type B live vaccine strain (LVS). Appl Microbiol Biotechnol. 2013;97:9029-41 pubmed publisher
    ..chromosomal green (GFP) and red fluorescent (RFP) reporters in the genome of the surrogate strain, Francisella tularensis spp. holarctica LVS (herein LVS), and the select agent, F. tularensis Schu S4...
  66. Apicella M, Post D, Fowler A, Jones B, Rasmussen J, Hunt J, et al. Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of Francisella tularensis. PLoS ONE. 2010;5:e11060 pubmed publisher
    ..b>Francisella tularensis has been considered to express a capsular antigen but none has been isolated or characterized...
  67. Rodriguez A, Yu J, Murthy A, Guentzel M, Klose K, Forsthuber T, et al. Mast cell/IL-4 control of Francisella tularensis replication and host cell death is associated with increased ATP production and phagosomal acidification. Mucosal Immunol. 2011;4:217-26 pubmed publisher
    ..that mast cells and secreted interleukin-4 (IL-4) effectively control intramacrophage replication of Francisella tularensis Live Vaccine Strain (LVS), and that mice deficient in mast cells or IL-4 receptor (IL-4R(-/-)) exhibit ..
  68. Reis C, Cote M, Paul R, Bonnet S. Questing ticks in suburban forest are infected by at least six tick-borne pathogens. Vector Borne Zoonotic Dis. 2011;11:907-16 pubmed publisher
    ..6%), Babesia sp. EU1 (~1%), Bartonella birtlesii (0.1%), and Francisella tularensis (!1%)...
  69. Clemens D, Lee B, Horwitz M. O-antigen-deficient Francisella tularensis Live Vaccine Strain mutants are ingested via an aberrant form of looping phagocytosis and show altered kinetics of intracellular trafficking in human macrophages. Infect Immun. 2012;80:952-67 pubmed publisher
    ..Thus, the O antigen plays a role in the morphology of uptake in the presence of complement and the kinetics of intracellular growth but is not essential for escape, survival, altered membrane trafficking, or intramacrophage growth...
  70. Svetlanov A, Puri N, Mena P, Koller A, Karzai A. Francisella tularensis tmRNA system mutants are vulnerable to stress, avirulent in mice, and provide effective immune protection. Mol Microbiol. 2012;85:122-41 pubmed publisher
    ..is necessary for normal growth, adaptation to cellular stress and virulence by the bacterial pathogen Francisella tularensis. The mutant bacteria grow slower, have reduced resistance to heat and cold shocks, and are more sensitive ..
  71. Boltje T, Zhong W, Park J, Wolfert M, Chen W, Boons G. Chemical synthesis and immunological evaluation of the inner core oligosaccharide of Francisella tularensis. J Am Chem Soc. 2012;134:14255-62 pubmed publisher
    b>Francisella tularensis, which is a Gram negative bacterium that causes tularemia, has been classified by the Center for Disease Control and Prevention (CDC) as a category A bioweapon...
  72. Kreizinger Z, Makrai L, Helyes G, Magyar T, Erdélyi K, Gyuranecz M. Antimicrobial susceptibility of Francisella tularensis subsp. holarctica strains from Hungary, Central Europe. J Antimicrob Chemother. 2013;68:370-3 pubmed publisher
    Determining the in vitro susceptibility to 11 antibiotics of Francisella tularensis subsp. holarctica strains belonging to the phylogenetic group B.13, from different areas of Hungary.
  73. Celli J, Zahrt T. Mechanisms of Francisella tularensis intracellular pathogenesis. Cold Spring Harb Perspect Med. 2013;3:a010314 pubmed publisher
    b>Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the debilitating febrile illness tularemia. Although natural infections by F...
  74. Petersen J, Molins C. Subpopulations of Francisella tularensis ssp. tularensis and holarctica: identification and associated epidemiology. Future Microbiol. 2010;5:649-61 pubmed publisher
    Tularemia is primarily caused by two subspecies of Francisella tularensis worldwide, ssp. tularensis (type A) and ssp. holarctica (type B), which were originally delineated by phenotypic differences...
  75. Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W. Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy. PLoS ONE. 2010;5:e13349 pubmed publisher
    b>Francisella tularensis is a facultative intracellular bacterial pathogen and the etiological agent of tularemia. The subspecies F...
  76. Chanturia G, Birdsell D, Kekelidze M, Zhgenti E, Babuadze G, Tsertsvadze N, et al. Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia. BMC Microbiol. 2011;11:139 pubmed publisher
    b>Francisella tularensis, the causative agent of tularemia, displays subspecies-specific differences in virulence, geographic distribution, and genetic diversity. F. tularensis subsp...
  77. Kim T, Pinkham J, Heninger S, Chalabaev S, Kasper D. Genetic modification of the O-polysaccharide of Francisella tularensis results in an avirulent live attenuated vaccine. J Infect Dis. 2012;205:1056-65 pubmed publisher
    b>Francisella tularensis, the causative agent of tularemia, is a highly virulent microbe. One significant virulence factor of F. tularensis is the O-polysaccharide (O-PS) portion of the organism's lipopolysaccharide.
  78. Schwartz J, Barker J, Long M, Kaufman J, McCracken J, Allen L. Natural IgM mediates complement-dependent uptake of Francisella tularensis by human neutrophils via complement receptors 1 and 3 in nonimmune serum. J Immunol. 2012;189:3064-77 pubmed publisher
    A fundamental step in the life cycle of Francisella tularensis is bacterial entry into host cells. F...
  79. Rees D, Hartley M, Green M, Lukaszewski R, Griffin K, Atkins H, et al. The ability of CpG oligonucleotides to protect mice against Francisella tularensis live vaccine strain but not fully virulent F. tularensis subspecies holarctica is reflected in cell-based assays. Microb Pathog. 2013;63:16-8 pubmed publisher
    ..Here the protective effects of CpG DNA are assessed against the facultative intracellular pathogen Francisella tularensis. Dosing of mice with CpG DNA provided protection against disease caused by F. tularensis subsp...
  80. Edwards J, Rockx Brouwer D, Nair V, Celli J. Restricted cytosolic growth of Francisella tularensis subsp. tularensis by IFN-gamma activation of macrophages. Microbiology. 2010;156:327-39 pubmed publisher
    The intracellular bacterium Francisella tularensis ensures its survival and proliferation within phagocytes of the infected host through phagosomal escape and cytosolic replication, to cause the disease tularemia...
  81. Melillo A, Bakshi C, Melendez J. Francisella tularensis antioxidants harness reactive oxygen species to restrict macrophage signaling and cytokine production. J Biol Chem. 2010;285:27553-60 pubmed publisher
    b>Francisella tularensis is the etiologic agent of the highly infectious animal and human disease tularemia...
  82. Nelson M, Lever M, Dean R, Pearce P, Stevens D, Simpson A. Bioavailability and efficacy of levofloxacin against Francisella tularensis in the common marmoset (Callithrix jacchus). Antimicrob Agents Chemother. 2010;54:3922-6 pubmed publisher
    ..Marmosets were challenged with a mean of 1.5 x 10(2) CFU of Francisella tularensis by the airborne route. Treated animals were administered 16...
  83. Mortensen B, Fuller J, Taft Benz S, Kijek T, Miller C, Huang M, et al. Effects of the putative transcriptional regulator IclR on Francisella tularensis pathogenesis. Infect Immun. 2010;78:5022-32 pubmed publisher
    b>Francisella tularensis is a highly virulent Gram-negative bacterium and is the etiological agent of the disease tularemia. IclR, a presumed transcriptional regulator, is required for full virulence of the animal pathogen, F...
  84. Lindgren H, Honn M, Salomonsson E, Kuoppa K, Forsberg A, Sjostedt A. Iron content differs between Francisella tularensis subspecies tularensis and subspecies holarctica strains and correlates to their susceptibility to H(2)O(2)-induced killing. Infect Immun. 2011;79:1218-24 pubmed publisher
    b>Francisella tularensis, the causative agent of tularemia, is one of the most infectious bacterial pathogens known and is classified as a category A select agent and a facultative intracellular bacterium. Why F. tularensis subsp...
  85. Mara Koosham G, Hutt J, Lyons C, Wu T. Antibodies contribute to effective vaccination against respiratory infection by type A Francisella tularensis strains. Infect Immun. 2011;79:1770-8 pubmed publisher
    ..is a life-threatening disease caused by inhalation of the highly infectious intracellular bacterium Francisella tularensis. The most serious form of the disease associated with the type A strains can be prevented in experimental ..
  86. Molins C, Delorey M, Yockey B, Young J, Sheldon S, Reese S, et al. Virulence differences among Francisella tularensis subsp. tularensis clades in mice. PLoS ONE. 2010;5:e10205 pubmed publisher
    b>Francisella tularensis subspecies tularensis (type A) and holarctica (type B) are of clinical importance in causing tularemia...
  87. Zaide G, Grosfeld H, Ehrlich S, Zvi A, Cohen O, Shafferman A. Identification and characterization of novel and potent transcription promoters of Francisella tularensis. Appl Environ Microbiol. 2011;77:1608-18 pubmed publisher
    ..and on the chloramphenicol acetyltransferase (cat) cassette, were constructed for isolation of potent Francisella tularensis promoters. Of the 26,000 F...
  88. Valentino M, Maben Z, Hensley L, Woolard M, Kawula T, Frelinger J, et al. Identification of T-cell epitopes in Francisella tularensis using an ordered protein array of serological targets. Immunology. 2011;132:348-60 pubmed publisher
    b>Francisella tularensis is a Gram-negative intracellular bacterium that is the causative agent of tularaemia...
  89. Simsek H, Taner M, Karadenizli A, Ertek M, Vahaboglu H. Identification of Francisella tularensis by both culture and real-time TaqMan PCR methods from environmental water specimens in outbreak areas where tularemia cases were not previously reported. Eur J Clin Microbiol Infect Dis. 2012;31:2353-7 pubmed publisher
    Tularemia is an endemic disease in Turkey. In this study, we aimed to detect Francisella tularensis by two methods from natural water supplies thought to cause tularemia epidemiologically...
  90. Matero P, Hemmilä H, Tomaso H, Piiparinen H, Rantakokko Jalava K, Nuotio L, et al. Rapid field detection assays for Bacillus anthracis, Brucella spp., Francisella tularensis and Yersinia pestis. Clin Microbiol Infect. 2011;17:34-43 pubmed publisher
    ..Assay sensitivities for B. anthracis, Brucella spp., Francisella tularensis and Yersinia pestis were 10-100 fg of target DNA per reaction, and no significant difference in assay ..
  91. Twine S, Petit M, Fulton K, House R, Conlan J. Immunoproteomics analysis of the murine antibody response to vaccination with an improved Francisella tularensis live vaccine strain (LVS). PLoS ONE. 2010;5:e10000 pubmed publisher
    b>Francisella tularensis subspecies tularensis is the causative agent of a spectrum of diseases collectively known as tularemia...
  92. Gyuranecz M, Szeredi L, Makrai L, Fodor L, Mészáros A, Szépe B, et al. Tularemia of European Brown Hare (Lepus europaeus): a pathological, histopathological, and immunohistochemical study. Vet Pathol. 2010;47:958-63 pubmed publisher
    ..The aim of the present study was to examine the lesions induced by Francisella tularensis in 50 cases of naturally infected seropositive European brown hares...