burkholderia cepacia

Summary

Summary: A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.

Top Publications

  1. Dales L, Ferris W, Vandemheen K, Aaron S. Combination antibiotic susceptibility of biofilm-grown Burkholderia cepacia and Pseudomonas aeruginosa isolated from patients with pulmonary exacerbations of cystic fibrosis. Eur J Clin Microbiol Infect Dis. 2009;28:1275-9 pubmed publisher
    We identified double and triple antibiotic combinations effective against biofilm-grown Burkholderia cepacia and Pseudomonas aeruginosa sampled from cystic fibrosis (CF) patients undergoing acute pulmonary exacerbations...
  2. Major T, Panmanee W, Mortensen J, Gray L, Hoglen N, Hassett D. Sodium nitrite-mediated killing of the major cystic fibrosis pathogens Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia under anaerobic planktonic and biofilm conditions. Antimicrob Agents Chemother. 2010;54:4671-7 pubmed publisher
    ..mutant and a sequenced nonmucoid strain, PAO1), Staphylococcus aureus USA300 (methicillin resistant), and Burkholderia cepacia, a notoriously antibiotic-resistant organism...
  3. Coenye T, Spilker T, Van Schoor A, LiPuma J, Vandamme P. Recovery of Burkholderia cenocepacia strain PHDC from cystic fibrosis patients in Europe. Thorax. 2004;59:952-4 pubmed
    ..Subsequent analysis of these isolates using BOX-PCR confirmed that the European isolates and strain PHDC represent the same clone. Strain PHDC represents a second transatlantic B cenocepacia clone capable of colonising patients with CF. ..
  4. Hadjiliadis D, Steele M, Chaparro C, Singer L, Waddell T, Hutcheon M, et al. Survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than Burkholderia cepacia, compared with patients harboring sensitive bacteria. J Heart Lung Transplant. 2007;26:834-8 pubmed
    The impact of panresistant bacteria, other than Burkholderia cepacia, on the survival after lung transplantation in patients with cystic fibrosis (CF) remains controversial...
  5. Bressler A, Kaye K, LiPuma J, Alexander B, Moore C, Reller L, et al. Risk factors for Burkholderia cepacia complex bacteremia among intensive care unit patients without cystic fibrosis: a case-control study. Infect Control Hosp Epidemiol. 2007;28:951-8 pubmed
    The Burkholderia cepacia complex is associated with colonization or disease in patients with cystic fibrosis (CF). For patients without CF, this complex is poorly understood apart from its presence in occasional point source outbreaks...
  6. Cunha M, Pinto de Oliveira A, Meirinhos Soares L, Salgado M, Melo Cristino J, Correia S, et al. Exceptionally high representation of Burkholderia cepacia among B. cepacia complex isolates recovered from the major Portuguese cystic fibrosis center. J Clin Microbiol. 2007;45:1628-33 pubmed
    b>Burkholderia cepacia, a species found infrequently in cystic fibrosis (CF), was isolated from 85% of patients infected with bacteria of the B. cepacia complex that visited the major Portuguese CF center, in Lisbon, during 2003 to 2005...
  7. Law R, Hamlin J, Sivro A, McCorrister S, Cardama G, Cardona S. A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model. J Bacteriol. 2008;190:7209-18 pubmed publisher
    Burkholderia cenocepacia is a member of the Burkholderia cepacia complex, a group of metabolically versatile bacteria that have emerged as opportunistic pathogens in cystic fibrosis and immunocompromised patients...
  8. Sousa S, Moreira L, Wopperer J, Eberl L, Sá Correia I, Leitão J. The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities. Biochem Biophys Res Commun. 2007;353:200-6 pubmed
    The bceA gene is part of the Burkholderia cepacia IST408 exopolysaccharide (EPS) biosynthetic cluster. It encodes a 55...
  9. Estivariz C, Bhatti L, Pati R, Jensen B, Arduino M, Jernigan D, et al. An outbreak of Burkholderia cepacia associated with contamination of albuterol and nasal spray. Chest. 2006;130:1346-53 pubmed
    Species within the Burkholderia cepacia complex (Bcc) can contaminate medications and disinfectants and cause severe pneumonia in critically ill patients or persons with cystic fibrosis...

More Information

Publications83

  1. Kilani Feki O, Culioli G, Ortalo Magné A, Zouari N, Blache Y, Jaoua S. Environmental Burkholderia cepacia strain Cs5 acting by two analogous alkyl-quinolones and a didecyl-phthalate against a broad spectrum of phytopathogens fungi. Curr Microbiol. 2011;62:1490-5 pubmed publisher
    An environmental Burkholderia cepacia strain named Cs5 was isolated and identified first using API biochemical identification system and then with 16S rDNA and recA sequence homology search...
  2. Jones A, Dodd M, Govan J, Barcus V, Doherty C, Morris J, et al. Burkholderia cenocepacia and Burkholderia multivorans: influence on survival in cystic fibrosis. Thorax. 2004;59:948-51 pubmed
    b>Burkholderia cepacia infection has been associated with a poor prognosis for patients with cystic fibrosis (CF)...
  3. Dizbay M, Tunccan O, Sezer B, Aktas F, Arman D. Nosocomial Burkholderia cepacia infections in a Turkish university hospital: a five-year surveillance. J Infect Dev Ctries. 2009;3:273-7 pubmed
    b>Burkholderia cepacia has the potential to cause fatal infections in ICUs, and multidrug resistance makes them a serious threat in hospital settings. The aim of this study was to evaluate the epidemiology of B...
  4. George R, Cartier Y, Casson A, Hernandez P. Suppurative mediastinitis secondary to Burkholderia cepacia in a patient with cystic fibrosis. Can Respir J. 2006;13:215-8 pubmed
    b>Burkholderia cepacia is an important opportunistic pathogen among patients with cystic fibrosis (CF); it is associated with deterioration of lung function, poor outcome following lung transplantation and increased mortality...
  5. Vanlaere E, Coenye T, Samyn E, Van den Plas C, Govan J, De Baets F, et al. A novel strategy for the isolation and identification of environmental Burkholderia cepacia complex bacteria. FEMS Microbiol Lett. 2005;249:303-7 pubmed
    The purpose of this study was to develop a novel strategy for the isolation and identification of Burkholderia cepacia complex bacteria from the home environment of cystic fibrosis (CF) patients...
  6. Wigfield S, Rigg G, Kavari M, Webb A, Matthews R, Burnie J. Identification of an immunodominant drug efflux pump in Burkholderia cepacia. J Antimicrob Chemother. 2002;49:619-24 pubmed
    b>Burkholderia cepacia, a major pathogen amongst individuals with cystic fibrosis (CF), is intrinsically resistant to most clinically available antibiotics...
  7. Abe K, D Angelo M, Sunenshine R, Noble Wang J, Cope J, Jensen B, et al. Outbreak of Burkholderia cepacia bloodstream infection at an outpatient hematology and oncology practice. Infect Control Hosp Epidemiol. 2007;28:1311-3 pubmed
    ..Though we did not identify the source of the organism, our findings support the hypothesis that cross-contamination of multidose medications through the use of the same needle and syringe was a contributing factor...
  8. Zhu C, Nomura C, Perrotta J, Stipanovic A, Nakas J. Production and characterization of poly-3-hydroxybutyrate from biodiesel-glycerol by Burkholderia cepacia ATCC 17759. Biotechnol Prog. 2010;26:424-30 pubmed publisher
    ..b>Burkholderia cepacia ATCC 17759 synthesized poly-3-hydroxybutyrate (PHB) from glycerol concentrations ranging from 3% to 9% (v/v)..
  9. Aggarwal N, Garg S, Pannu H, Kler T. Fatal Burkholderia cepacia early prosthetic valve endocarditis: a very rare case and a review of the literature. J Heart Valve Dis. 2005;14:271-4 pubmed
    ..Serial blood cultures grew Burkholderia cepacia at four to five days after incubation...
  10. Mariappan V, Vellasamy K, Hashim O, Vadivelu J. Profiling of Burkholderia cepacia secretome at mid-logarithmic and early-stationary phases of growth. PLoS ONE. 2011;6:e26518 pubmed publisher
    b>Burkholderia cepacia is a Gram-negative pathogen that causes serious respiratory infections in immunocompromised patients and individuals with cystic fibrosis...
  11. Held M, Begier E, Beardsley D, Browne F, Martinello R, Baltimore R, et al. Life-threatening sepsis caused by Burkholderia cepacia from contaminated intravenous flush solutions prepared by a compounding pharmacy in another state. Pediatrics. 2006;118:e212-5 pubmed
    We report 2 life-threatening cases of Burkholderia cepacia sepsis caused by infusate contamination during compounding...
  12. De Smet B, Veng C, Kruy L, Kham C, van Griensven J, Peeters C, et al. Outbreak of Burkholderia cepacia bloodstream infections traced to the use of Ringer lactate solution as multiple-dose vial for catheter flushing, Phnom Penh, Cambodia. Clin Microbiol Infect. 2013;19:832-7 pubmed publisher
    The Burkholderia cepacia complex is a group of Gram-negative bacteria known as respiratory pathogens in cystic fibrosis patients, but also increasingly reported as a cause of healthcare associated infections. We describe an outbreak of B...
  13. Rocha J, Popescu A, Borges P, Mil Homens D, Moreira L, Sá Correia I, et al. Structure of Burkholderia cepacia UDP-glucose dehydrogenase (UGD) BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate. J Bacteriol. 2011;193:3978-87 pubmed publisher
    Members of the Burkholderia cepacia complex (BCC) are serious respiratory pathogens in immunocompromised individuals and in patients with cystic fibrosis (CF)...
  14. Traczewski M, Brown S. In vitro activity of doripenem against Pseudomonas aeruginosa and Burkholderia cepacia isolates from both cystic fibrosis and non-cystic fibrosis patients. Antimicrob Agents Chemother. 2006;50:819-21 pubmed
    ..for 160 isolates of Pseudomonas aeruginosa (82 from cystic fibrosis [CF] patients) and 34 isolates of Burkholderia cepacia. Doripenem MIC90s were lower than those of all other comparative agents against all isolates combined and ..
  15. Schneider D, Ayres J, Brandt S, Costa A, Dionne M, Gordon M, et al. Drosophila eiger mutants are sensitive to extracellular pathogens. PLoS Pathog. 2007;3:e41 pubmed
    ..We propose that eiger activates the cellular immune response of the fly to aid clearance of extracellular pathogens. Intracellular pathogens, which can already defeat professional phagocytes, are unaffected by eiger...
  16. Alvarez Lerma F, Maull E, Terradas R, Segura C, Planells I, Coll P, et al. Moisturizing body milk as a reservoir of Burkholderia cepacia: outbreak of nosocomial infection in a multidisciplinary intensive care unit. Crit Care. 2008;12:R10 pubmed publisher
    An outbreak of severe nosocomial Burkholderia cepacia infections in patients admitted to intensive care unit (ICU), including investigation of the reservoir, is described.
  17. Herasimenka Y, Cescutti P, Impallomeni G, Campana S, Taccetti G, Ravenni N, et al. Exopolysaccharides produced by clinical strains belonging to the Burkholderia cepacia complex. J Cyst Fibros. 2007;6:145-52 pubmed
    ..better clarify the role of exopolysaccharides (EPS) in bacterial virulence, EPS produced by species of the Burkholderia cepacia complex (Bcc), namely Burkholderia multivorans, Burkholderia cenocepacia, and a Bcc member of undetermined ..
  18. Wani R, Kodam K, Gawai K, Dhakephalkar P. Chromate reduction by Burkholderia cepacia MCMB-821, isolated from the pristine habitat of alkaline crater lake. Appl Microbiol Biotechnol. 2007;75:627-32 pubmed
    ..bacterial strain MCMB-821 was isolated from the alkaline crater lake of Lonar and was identified as Burkholderia cepacia. MCMB-821 was resistant to 1,000-ppm Cr(VI) and reduced 98% of the 75 ppm Cr(VI) within 36 h at pH 9...
  19. Romero Gómez M, Quiles Melero M, Peña García P, Gutiérrez Altés A, García de Miguel M, Jimenez C, et al. Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit. Infect Control Hosp Epidemiol. 2008;29:377-8 pubmed publisher
  20. Lin T, Huang H, Shen F, Young C. The protons of gluconic acid are the major factor responsible for the dissolution of tricalcium phosphate by Burkholderia cepacia CC-Al74. Bioresour Technol. 2006;97:957-60 pubmed
    b>Burkholderia cepacia CC-Al74 with a high ability for solubilizing tricalcium phosphate (TCP) was used to study the P-solubilization mechanism...
  21. Lynch K, Seed K, Stothard P, Dennis J. Inactivation of Burkholderia cepacia complex phage KS9 gp41 identifies the phage repressor and generates lytic virions. J Virol. 2010;84:1276-88 pubmed publisher
    The Burkholderia cepacia complex (BCC) is made up of at least 17 species of gram-negative opportunistic bacterial pathogens that cause fatal infections in patients with cystic fibrosis and chronic granulomatous disease...
  22. Mariappan V, Vellasamy K, Thimma J, Hashim O, Vadivelu J. Identification of immunogenic proteins from Burkholderia cepacia secretome using proteomic analysis. Vaccine. 2010;28:1318-24 pubmed publisher
    b>Burkholderia cepacia is an opportunistic human pathogen associated with lung infections. Secretory proteins of B. cepacia are known to be involved in virulence and may mediate important host-pathogen interactions...
  23. Hwang G, Kang S, El Din M, Liu Y. Impact of conditioning films on the initial adhesion of Burkholderia cepacia. Colloids Surf B Biointerfaces. 2012;91:181-8 pubmed publisher
    ..Three Burkholderia cepacia strains with different extracellular polymeric substance (EPS) secretion capacities were tested...
  24. Courtney J, Dunbar K, McDowell A, Moore J, Warke T, Stevenson M, et al. Clinical outcome of Burkholderia cepacia complex infection in cystic fibrosis adults. J Cyst Fibros. 2004;3:93-8 pubmed
    The Burkholderia cepacia complex (BCC) is one of the most important groups of organisms infecting cystic fibrosis (CF) patients. The aim of the study was to examine how infection with BCC affects clinical outcome.
  25. Yang C, Chen T, Liao L, Ma L, Wang C, Lu P, et al. Nosocomial outbreak of two strains of Burkholderia cepacia caused by contaminated heparin. J Hosp Infect. 2008;69:398-400 pubmed publisher
  26. Miñán A, Bosch A, Lasch P, Stämmler M, Serra D, Degrossi J, et al. Rapid identification of Burkholderia cepacia complex species including strains of the novel Taxon K, recovered from cystic fibrosis patients by intact cell MALDI-ToF mass spectrometry. Analyst. 2009;134:1138-48 pubmed publisher
    ..mass spectrometry (IC-MALDI-ToF MS) have been evaluated in order to discriminate and identify nine former Burkholderia cepacia complex (Bcc) species, Burkholderia contaminans belonging to the novel Taxon K, Burkholderia gladioli, and ..
  27. Carvalho A, Ventura G, Pereira C, Leão R, Folescu T, Higa L, et al. Burkholderia cenocepacia, B. multivorans, B. ambifaria and B. vietnamiensis isolates from cystic fibrosis patients have different profiles of exoenzyme production. APMIS. 2007;115:311-8 pubmed
    Knowledge about the virulence mechanisms of species from the Burkholderia cepacia complex (BCC) is still limited...
  28. Da Rós P, Silva G, Mendes A, Santos J, de Castro H. Evaluation of the catalytic properties of Burkholderia cepacia lipase immobilized on non-commercial matrices to be used in biodiesel synthesis from different feedstocks. Bioresour Technol. 2010;101:5508-16 pubmed publisher
    The objective of this work was to produce an immobilized form of lipase from Burkholderia cepacia (lipase PS) with advantageous catalytic properties and stability to be used in the ethanolysis of different feedstocks, mainly babassu oil ..
  29. Van Acker H, Sass A, Bazzini S, De Roy K, Udine C, Messiaen T, et al. Biofilm-grown Burkholderia cepacia complex cells survive antibiotic treatment by avoiding production of reactive oxygen species. PLoS ONE. 2013;8:e58943 pubmed publisher
    ..In the present study we investigated whether persister cells are present in Burkholderia cepacia complex (Bcc) biofilms, what the molecular basis of antimicrobial tolerance in Bcc persisters is, and how ..
  30. Subsin B, Chambers C, Visser M, Sokol P. Identification of genes regulated by the cepIR quorum-sensing system in Burkholderia cenocepacia by high-throughput screening of a random promoter library. J Bacteriol. 2007;189:968-79 pubmed
    ..This study extends our understanding of genes whose expression is influenced by cepIR and indicates the global regulatory effect of the cepIR system in B. cenocepacia...
  31. Berthelot P, Grattard F, Mallaval F, Ros A, Lucht F, Pozzetto B. [Epidemiology of nosocomial infections due to Pseudomonas aeruginosa, Burkholderia cepacia and Stenotrophomonas maltophilia]. Pathol Biol (Paris). 2005;53:341-8 pubmed
  32. Strino F, Nahmany A, Rosen J, Kemp G, Sá Correia I, Nyholm P. Conformation of the exopolysaccharide of Burkholderia cepacia predicted with molecular mechanics (MM3) using genetic algorithm search. Carbohydr Res. 2005;340:1019-24 pubmed
    We present a computational conformational analysis of the exopolysaccharide of Burkholderia cepacia, which is believed to play a role in colonization and persistence of B. cepacia in the lungs of cystic fibrosis patients...
  33. Chambers C, Visser M, Schwab U, Sokol P. Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients. FEMS Microbiol Lett. 2005;244:297-304 pubmed
    Pseudomonas aeruginosa and species of the Burkholderia cepacia complex are the primary bacterial pathogens contributing to lung disease in patients with cystic fibrosis...
  34. Keenan T, Tanenbaum S, Stipanovic A, Nakas J. Production and characterization of poly-beta-hydroxyalkanoate copolymers from Burkholderia cepacia utilizing xylose and levulinic acid. Biotechnol Prog. 2004;20:1697-704 pubmed
    ..P(3HB-co-3HV)) copolymers were prepared via shake-flask fermentations of Burkholderia cepacia (formerly Pseudomonas cepacia) containing 2...
  35. Madala N, Molinaro A, Dubery I. Distinct carbohydrate and lipid-based molecular patterns within lipopolysaccharides from Burkholderia cepacia contribute to defense-associated differential gene expression in Arabidopsis thaliana. Innate Immun. 2012;18:140-54 pubmed publisher
    ..LPS from Burkholderia cepacia as well as two fragments, the glycolipid, lipid A and the polysaccharide (OPS-core) chain, were used to ..
  36. Pope C, Gillespie S, Pratten J, McHugh T. Fluoroquinolone-resistant mutants of Burkholderia cepacia. Antimicrob Agents Chemother. 2008;52:1201-3 pubmed
    Fluoroquinolone-resistant Burkholderia cepacia mutants were selected on ciprofloxacin. The rate of mutation in gyrA was estimated to be 9.6 x 10(-11) mutations per division...
  37. de Los Santos Villalobos S, Barrera Galicia G, Miranda Salcedo M, Peña Cabriales J. Burkholderia cepacia XXVI siderophore with biocontrol capacity against Colletotrichum gloeosporioides. World J Microbiol Biotechnol. 2012;28:2615-23 pubmed publisher
    Colletotrichum gloeosporioides is the causal agent of anthracnose in mango. Burkholderia cepacia XXVI, isolated from mango rhizosphere and identified by 16S rDNA sequencing as a member of B...
  38. Pan S, Liu X, Xie Y, Yi Y, Li C, Yan Y, et al. Esterification activity and conformation studies of Burkholderia cepacia lipase in conventional organic solvents, ionic liquids and their co-solvent mixture media. Bioresour Technol. 2010;101:9822-4 pubmed publisher
    ..work, experiments were carried out to evaluate the esterification activity and conformation of lipase from Burkholderia cepacia in the selected conventional organic solvents, ionic liquids and their co-solvent mixture media...
  39. Coutinho H. Burkholderia cepacia complex: virulence characteristics, importance and relationship with cystic fibrosis. Indian J Med Sci. 2007;61:422-9 pubmed
    b>Burkholderia cepacia has been described as a cause of opportunist infections in patients with immune deficiency because of the high transmission rates. Actually the B...
  40. Balkhy H, Cunningham G, Francis C, Almuneef M, Stevens G, Akkad N, et al. A National Guard outbreak of Burkholderia cepacia infection and colonization secondary to intrinsic contamination of albuterol nebulization solution. Am J Infect Control. 2005;33:182-8 pubmed
    b>Burkholderia cepacia, a gram-negative pathogen, has been a known cause of hospital outbreaks because of a contaminated common source such as multidose medications...
  41. Bernier S, Sokol P. Use of suppression-subtractive hybridization to identify genes in the Burkholderia cepacia complex that are unique to Burkholderia cenocepacia. J Bacteriol. 2005;187:5278-91 pubmed
    We have previously shown differences in virulence between species of the Burkholderia cepacia complex using the alfalfa infection model and the rat agar bead chronic infection model...
  42. Liu Y, Chen D, Yan Y, Peng C, Xu L. Biodiesel synthesis and conformation of lipase from Burkholderia cepacia in room temperature ionic liquids and organic solvents. Bioresour Technol. 2011;102:10414-8 pubmed publisher
    Biodiesel synthesis and conformation of Burkholderia cepacia lipase (BCL) were studied in 19 different room temperature ionic liquids (RTLLs) with a range of cation and anion structures...
  43. Liao C, Chang H, Lai C, Huang Y, Hsu M, Liu C, et al. Clinical characteristics and outcomes of patients with Burkholderia cepacia bacteremia in an intensive care unit. Diagn Microbiol Infect Dis. 2011;70:260-6 pubmed publisher
    The purpose of this study was to investigate a cohort of patients with Burkholderia cepacia bacteremia in the intensive care unit (ICU) at our institution. A large outbreak of B...
  44. Chambers C, Lutter E, Visser M, Law P, Sokol P. Identification of potential CepR regulated genes using a cep box motif-based search of the Burkholderia cenocepacia genome. BMC Microbiol. 2006;6:104 pubmed
    ..A bioinformatics approach was used to screen the B. cenocepacia J2315 genome for CepR binding site motifs...
  45. Leungsakul T, Keenan B, Smets B, Wood T. TNT and nitroaromatic compounds are chemoattractants for Burkholderia cepacia R34 and Burkholderia sp. strain DNT. Appl Microbiol Biotechnol. 2005;69:321-5 pubmed
    ..In this study, a drop assay was used to detect chemotaxis toward nitroaromatic compounds for wild-type Burkholderia cepacia R34, wild-type Burkholderia sp...
  46. Mezzetti A, Schrag J, Cheong C, Kazlauskas R. Mirror-image packing in enantiomer discrimination molecular basis for the enantioselectivity of B.cepacia lipase toward 2-methyl-3-phenyl-1-propanol. Chem Biol. 2005;12:427-37 pubmed
    ..The crystal structures of two phosphonate transition-state analogs bound to Burkholderia cepacia lipase reveal this molecular basis for a typical primary alcohol: 2-methyl-3-phenyl-1-propanol...
  47. Li X, Quan C, Fan S. Antifungal activity of a novel compound from Burkholderia cepacia against plant pathogenic fungi. Lett Appl Microbiol. 2007;45:508-14 pubmed
    ..To investigate antifungal activity of a novel compound (named as CF66I provisionally) against plant pathogenic fungi, mainly including Fusarium sp., Colletotrichum lindemuthianum, Rhizoctonia solani, etc...
  48. Livermore D, Mushtaq S, Ge Y, Warner M. Activity of cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa and Burkholderia cepacia group strains and isolates. Int J Antimicrob Agents. 2009;34:402-6 pubmed publisher
    ..aeruginosa and Burkholderia cepacia. Minimum inhibitory concentrations (MICs) of CXA-101 were determined by the Clinical and Laboratory ..
  49. Worgall S, Heguy A, Luettich K, O Connor T, Harvey B, Quadri L, et al. Similarity of gene expression patterns in human alveolar macrophages in response to Pseudomonas aeruginosa and Burkholderia cepacia. Infect Immun. 2005;73:5262-8 pubmed
    ..severity of pulmonary infection in cystic fibrosis seen with late isolates of Pseudomonas aeruginosa and Burkholderia cepacia are associated with differences in the initial response of alveolar macrophages (AM) to these pathogens, we ..
  50. Webb B, Ballinger J, Kim E, Belchik S, Lam K, Youn B, et al. Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100. J Biol Chem. 2010;285:2014-27 pubmed publisher
    b>Burkholderia cepacia AC1100 completely degrades 2,4,5-trichlorophenol, in which an FADH(2)-dependent monooxygenase (TftD) and an NADH:FAD oxidoreductase (TftC) catalyze the initial steps...
  51. Godshall M. Mounting a defense against Burkholderia cepacia. Nursing. 2005;35:18-9 pubmed
  52. Jia B, Yang J, Liu W, Li X, Yan Y. Homologous overexpression of a lipase from Burkholderia cepacia using the lambda Red recombinase system. Biotechnol Lett. 2010;32:521-6 pubmed publisher
    ..Using this system, we obtained T7 RNA polymerase (RNAP) substitution mutants in Burkholderia cepacia. To test the expression abilities of the T7 mutants, four different lipase expression vectors were ..
  53. Merk S, Meyer H, Greiser Wilke I, Sprague L, Neubauer H. Detection of Burkholderia cepacia DNA from artificially infected EDTA-blood and lung tissue comparing different DNA isolation methods. J Vet Med B Infect Dis Vet Public Health. 2006;53:281-5 pubmed
    Bacterial DNA (Burkholderia cepacia) was prepared from artificially infected equine ethylenediaminetetraacetic acid (EDTA)-blood and lung tissue by using four standard methods (lysis buffer containing proteinase K, phenol/chloroform/..
  54. Taghavi S, Barac T, Greenberg B, Borremans B, Vangronsveld J, Van Der Lelie D. Horizontal gene transfer to endogenous endophytic bacteria from poplar improves phytoremediation of toluene. Appl Environ Microbiol. 2005;71:8500-5 pubmed
    ..for phytoremediation of groundwater contaminated with organic solvents, was inoculated with the endophyte Burkholderia cepacia VM1468...
  55. Marioni G, Rinaldi R, Ottaviano G, Marchese Ragona R, Savastano M, Staffieri A. Cervical necrotizing fasciitis: a novel clinical presentation of Burkholderia cepacia infection. J Infect. 2006;53:e219-22 pubmed
    ..We describe the first case of CNF due to multi-drug resistant Burkholderia cepacia and Peptostreptococcus infection in an immuno-competent patient without cystic fibrosis.
  56. Madala N, Leone M, Molinaro A, Dubery I. Deciphering the structural and biological properties of the lipid A moiety of lipopolysaccharides from Burkholderia cepacia strain ASP B 2D, in Arabidopsis thaliana. Glycobiology. 2011;21:184-94 pubmed publisher
    ..Environmental strains of Burkholderia cepacia have been described as phytopathogens, growth promotors, biocontrol agents and bioremediation agents...
  57. Eberl L, Tummler B. Pseudomonas aeruginosa and Burkholderia cepacia in cystic fibrosis: genome evolution, interactions and adaptation. Int J Med Microbiol. 2004;294:123-31 pubmed
    The Gram-negative bacteria Pseudomonas aeruginosa and Burkholderia cepacia are opportunistic human pathogens that are responsible for severe nosocomial infections in immunocompromised patients and are the major pathogens in cystic ..
  58. Pan W, Perrotta J, Stipanovic A, Nomura C, Nakas J. Production of polyhydroxyalkanoates by Burkholderia cepacia ATCC 17759 using a detoxified sugar maple hemicellulosic hydrolysate. J Ind Microbiol Biotechnol. 2012;39:459-69 pubmed publisher
    ..9 g/l of xylose was used as an inexpensive feedstock to produce polyhydroxyalkanoates (PHAs) by Burkholderia cepacia ATCC 17759...
  59. Fauroux B, Hart N, Belfar S, Boule M, Tillous Borde I, Bonnet D, et al. Burkholderia cepacia is associated with pulmonary hypertension and increased mortality among cystic fibrosis patients. J Clin Microbiol. 2004;42:5537-41 pubmed
    The aim of the study was to evaluate the impact of Burkholderia cepacia on cardiovascular status and mortality in cystic fibrosis. Seven patients infected with B...
  60. Fauré R, Shiao T, Lagnoux D, Giguère D, Roy R. En route to a carbohydrate-based vaccine against Burkholderia cepacia. Org Biomol Chem. 2007;5:2704-8 pubmed
    ..to the repeating unit 1 of an O-polysaccharide present in the lipopolysaccharide of clinical isolate of Burkholderia cepacia. The approach included two successive glycosylations, based on D-rhamnosyl trichloroacetimidate donors 12 ..
  61. Ghazal S, Al Mudaimeegh K, Al Fakihi E, Asery A. Outbreak of Burkholderia cepacia bacteremia in immunocompetent children caused by contaminated nebulized sulbutamol in Saudi Arabia. Am J Infect Control. 2006;34:394-8 pubmed
    ..The Infection Control Department (ICD) in the King Fahad Medical City (KFMC) detected and investigated the outbreak to identify the source of the organism and mode of transmission...
  62. Mitsui R, Hirota M, Tsuno T, Tanaka M. Purification and characterization of vanillin dehydrogenases from alkaliphile Micrococcus sp. TA1 and neutrophile Burkholderia cepacia TM1. FEMS Microbiol Lett. 2010;303:41-7 pubmed publisher
    ..The neutrophile Burkholderia cepacia TM1, which was isolated previously, also grew on the above-mentioned compounds because they functioned as ..
  63. Trodler P, Schmid R, Pleiss J. Modeling of solvent-dependent conformational transitions in Burkholderia cepacia lipase. BMC Struct Biol. 2009;9:38 pubmed publisher
    ..Therefore, molecular dynamics simulations of a closed homology model and an open crystal structure of Burkholderia cepacia lipase in water and toluene were performed to investigate the influence of solvents on structure, dynamics, ..
  64. Molina Cabrillana J, Bolaños Rivero M, Alvarez Leon E, Martín Sánchez A, Sánchez Palacios M, Alvarez D, et al. Intrinsically contaminated alcohol-free mouthwash implicated in a nosocomial outbreak of Burkholderia cepacia colonization and infection. Infect Control Hosp Epidemiol. 2006;27:1281-2 pubmed
  65. Ferreira A, Leitão J, Sousa S, Cosme A, Sá Correia I, Moreira L. Functional analysis of Burkholderia cepacia genes bceD and bceF, encoding a phosphotyrosine phosphatase and a tyrosine autokinase, respectively: role in exopolysaccharide biosynthesis and biofilm formation. Appl Environ Microbiol. 2007;73:524-34 pubmed
    The biosynthesis of the exopolysaccharide (EPS) cepacian by Burkholderia cepacia complex strains requires the 16.2-kb bce cluster of genes...
  66. Ekkhunnatham A, Jongsareejit B, Yamkunthong W, Wichitwechkarn J. Purification and characterization of methyl parathion hydrolase from Burkholderia cepacia capable of degrading organophosphate insecticides. World J Microbiol Biotechnol. 2012;28:1739-46 pubmed publisher
    Methyl parathion hydrolase (MPH) from a methyl parathion-degrading Burkholderia cepacia indigenous to Thailand was purified to apparent homogeneity by three steps of column chromatography using Resource S, Sephadex G100, and Octyl ..
  67. Souza A, Moreira C, Pasternak J, Hirata M, Saltini D, Caetano V, et al. Characterizing uncommon Burkholderia cepacia complex isolates from an outbreak in a haemodialysis unit. J Med Microbiol. 2004;53:999-1005 pubmed
    ..b>Burkholderia cepacia complex was the agent most frequently recovered from blood...
  68. Rüger M, Bensch G, Tüngler R, Reichl U. A flow cytometric method for viability assessment of Staphylococcus aureus and Burkholderia cepacia in mixed culture. Cytometry A. 2012;81:1055-66 pubmed publisher
    ..In this study, flow cytometry was applied to assess the viability of Staphylococcus aureus and Burkholderia cepacia in mixed culture by membrane integrity analysis using SYBR® Green I and propidium iodide staining...
  69. Ventura G, Balloy V, Ramphal R, Khun H, Huerre M, Ryffel B, et al. Lack of MyD88 protects the immunodeficient host against fatal lung inflammation triggered by the opportunistic bacteria Burkholderia cenocepacia. J Immunol. 2009;183:670-6 pubmed publisher
    ..Altogether, our findings demonstrate that a MyD88-dependent pathway can critically contribute to a detrimental host inflammatory response that leads to fatal pneumonia...
  70. Huber B, Feldmann F, Köthe M, Vandamme P, Wopperer J, Riedel K, et al. Identification of a novel virulence factor in Burkholderia cenocepacia H111 required for efficient slow killing of Caenorhabditis elegans. Infect Immun. 2004;72:7220-30 pubmed
    ..Furthermore, evidence is provided that AidA is produced not only by B. cenocepacia but also by many other strains of the Burkholderia cepacia complex.
  71. Li X, Yu H, Lin Y, Teng H, Du L, Ma G. Morphological changes of Fusarium oxysporum induced by CF66I, an antifungal compound from Burkholderia cepacia. Biotechnol Lett. 2010;32:1487-95 pubmed publisher
    The morphological effects of CF66I, an antifungal compound produced by Burkholderia cepacia, on growing hyphae of Fusarium oxysporum were studied by fluorescence microscopy (FM) and transmission electron microscopy (TEM)...
  72. Kooi C, Corbett C, Sokol P. Functional analysis of the Burkholderia cenocepacia ZmpA metalloprotease. J Bacteriol. 2005;187:4421-9 pubmed
    ..cenocepacia ZmpA may cause direct tissue damage to the host or damage to host tissues through a modulation of the host's immune system...
  73. Yang X, Teng F, Zeng H, Liu Y. Impact of cranberry juice on initial adhesion of the EPS producing bacterium Burkholderia cepacia. Biofouling. 2012;28:417-31 pubmed publisher
    ..juice was investigated with respect to the initial adhesion of three isogenic strains of the bacterium Burkholderia cepacia with different extracellular polymeric substance (EPS) producing capacities, viz...
  74. Rosengarten D, Block C, Hidalgo Grass C, Temper V, Gross I, Budin Mizrahi A, et al. Cluster of pseudoinfections with Burkholderia cepacia associated with a contaminated washer-disinfector in a bronchoscopy unit. Infect Control Hosp Epidemiol. 2010;31:769-71 pubmed publisher
    In December 2008, bronchoalveolar lavage fluid samples obtained from 3 patients were positive for Burkholderia cepacia complex on culture...