burkholderia cenocepacia


Summary: A species of gram-negative bacteria that causes disease in plants. It is found commonly in the environment and is an opportunistic pathogen in humans.

Top Publications

  1. Mesureur J, Feliciano J, Wagner N, Gomes M, Zhang L, Blanco Gonzalez M, et al. Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation. PLoS Pathog. 2017;13:e1006437 pubmed publisher
    ..We suggest that paradigm-changing approaches are needed for development of novel antimicrobials to efficiently disarm intracellular bacteria of this group of highly persistent, opportunistic pathogens. ..
  2. Liu Y, Lardi M, Pedrioli A, Eberl L, Pessi G. NtrC-dependent control of exopolysaccharide synthesis and motility in Burkholderia cenocepacia H111. PLoS ONE. 2017;12:e0180362 pubmed publisher
    b>Burkholderia cenocepacia is a versatile opportunistic pathogen that survives in a wide variety of environments, which can be limited in nutrients such as nitrogen...
  3. Dennis J. Burkholderia cenocepacia virulence microevolution in the CF lung: Variations on a theme. Virulence. 2017;8:618-620 pubmed publisher
  4. Van den Driessche F, Vanhoutte B, Brackman G, Crabbé A, Rigole P, Vercruysse J, et al. Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models. PLoS ONE. 2017;12:e0172723 pubmed publisher
    b>Burkholderia cenocepacia is an opportunistic pathogen responsible for life-threatening infections in cystic fibrosis patients. B...
  5. Guo F, Xiong L, Zhang K, Dong C, Zhang F, Woo P. Identification and analysis of genomic islands in Burkholderia cenocepacia AU 1054 with emphasis on pathogenicity islands. BMC Microbiol. 2017;17:73 pubmed publisher
    ..GIs have been identified in strain J2315 of Burkholderia cenocepacia, whereas in strain AU 1054 there has been no published works on such regions according to our text mining ..
  6. Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, et al. High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111. Microbiology. 2017;163:754-764 pubmed publisher
    The opportunistic human pathogen Burkholderia cenocepacia H111 uses two chemically distinct signal molecules for controlling gene expression in a cell density-dependent manner: N-acyl-homoserine lactones (AHLs) and cis-2-dodecenoic acid (..
  7. Kim Y, Chhor G, Tsai C, Fox G, Chen C, Winans N, et al. X-ray crystal structures of the pheromone-binding domains of two quorum-hindered transcription factors, YenR of Yersinia enterocolitica and CepR2 of Burkholderia cenocepacia. Proteins. 2017;85:1831-1844 pubmed publisher
    ..Another example is CepR2 of Burkholderia cenocepacia, which is antagonized by N-octanoyl-l-homoserine lactone (OHL), whose synthesis is directed by the cepI ..
  8. Higgins S, Sanchez Contreras M, Gualdi S, Pinto Carbó M, Carlier A, Eberl L. The Essential Genome of Burkholderia cenocepacia H111. J Bacteriol. 2017;199: pubmed publisher
    ..drug targets; hence, our aim was to identify the essential genome of the cystic fibrosis (CF) isolate Burkholderia cenocepacia H111...
  9. Yao G, Duarte Í, Le T, Carmody L, LiPuma J, Young R, et al. A Broad-Host-Range Tailocin from Burkholderia cenocepacia. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..As such, BceTMilo and related or modified tailocins have potential as bactericidal therapeutic agents against plant- and human-pathogenic Burkholderia. ..

More Information


  1. Vanhoutte B, Cappoen D, Maira B, Cools F, Torfs E, Coenye T, et al. Optimization and characterization of a murine lung infection model for the evaluation of novel therapeutics against Burkholderia cenocepacia. J Microbiol Methods. 2017;139:181-188 pubmed publisher
    ..As this mouse model is characterized by a reproducible course of infection and efficacy of TOB, it can be used as a tool for the in vivo evaluation of new antibacterial therapies. ..
  2. Borlee G, Plumley B, Martin K, Somprasong N, Mangalea M, Islam M, et al. Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene cluster. PLoS Negl Trop Dis. 2017;11:e0005689 pubmed publisher
    ..These findings will facilitate further advances in understanding the pathogenesis of B. pseudomallei and improve diagnostics and therapeutic treatment strategies. ..
  3. Moutinho T, Panagides J, Biggs M, Medlock G, Kolling G, Papin J. Novel co-culture plate enables growth dynamic-based assessment of contact-independent microbial interactions. PLoS ONE. 2017;12:e0182163 pubmed publisher
    ..Two bacterial species commonly found in the cystic fibrotic lung, Pseudomonas aeruginosa and Burkholderia cenocepacia, were co-cultured to demonstrate how this plate may be implemented to study microbial interactions...