burkholderia pseudomallei

Summary

Summary: A species of gram-negative, aerobic bacteria that causes MELIOIDOSIS. It has been isolated from soil and water in tropical regions, particularly Southeast Asia.

Top Publications

  1. Mima T, Kvitko B, Rholl D, Page M, Desarbre E, Schweizer H. In vitro activity of BAL30072 against Burkholderia pseudomallei. Int J Antimicrob Agents. 2011;38:157-9 pubmed publisher
    b>Burkholderia pseudomallei is an intrinsically antibiotic-resistant Category B priority pathogen and the aetiological agent of melioidosis. Treatment of B...
  2. Cuccui J, Milne T, Harmer N, George A, Harding S, Dean R, et al. Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region. Infect Immun. 2012;80:1209-21 pubmed publisher
    b>Burkholderia pseudomallei is the causative agent of melioidosis, a disease endemic to regions of Southeast Asia and Northern Australia...
  3. Wongtrakoongate P, Tumapa S, Tungpradabkul S. Regulation of a quorum sensing system by stationary phase sigma factor RpoS and their co-regulation of target genes in Burkholderia pseudomallei. Microbiol Immunol. 2012;56:281-94 pubmed publisher
    b>Burkholderia pseudomallei is the causative agent of a fatal disease, melioidosis. However, the mechanisms of pathogenesis and genes involved in its virulence are not understood...
  4. Sim S, Liu Y, Wang D, Novem V, Sivalingam S, Thong T, et al. Innate immune responses of pulmonary epithelial cells to Burkholderia pseudomallei infection. PLoS ONE. 2009;4:e7308 pubmed publisher
    b>Burkholderia pseudomallei, a facultative intracellular pathogen, causes systemic infection in humans with high mortality especially when infection occurs through an infectious aerosol...
  5. Lipscomb L, Schell M. Elucidation of the regulon and cis-acting regulatory element of HrpB, the AraC-type regulator of a plant pathogen-like type III secretion system in Burkholderia pseudomallei. J Bacteriol. 2011;193:1991-2001 pubmed publisher
    The human pathogen Burkholderia pseudomallei possesses multiple type III secretion system (T3SS) gene clusters. One of these, the B...
  6. Chin C, Tan S, Nathan S. Immunogenic recombinant Burkholderia pseudomallei MprA serine protease elicits protective immunity in mice. Front Cell Infect Microbiol. 2012;2:85 pubmed publisher
    b>Burkholderia pseudomallei is resistant to a diverse group of antimicrobials including third generation cephalosporins whilst quinolones and aminoglycosides have no reliable effect...
  7. Pumirat P, Cuccui J, Stabler R, Stevens J, Muangsombut V, Singsuksawat E, et al. Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system. BMC Microbiol. 2010;10:171 pubmed publisher
    b>Burkholderia pseudomallei is the causative agent of melioidosis where the highest reported incidence world wide is in the Northeast of Thailand, where saline soil and water are prevalent...
  8. Rattanavong S, Wuthiekanun V, Langla S, Amornchai P, Sirisouk J, Phetsouvanh R, et al. Randomized soil survey of the distribution of Burkholderia pseudomallei in rice fields in Laos. Appl Environ Microbiol. 2011;77:532-6 pubmed publisher
    Melioidosis is a major cause of morbidity and mortality in Southeast Asia, where the causative organism (Burkholderia pseudomallei) is present in the soil. In the Lao People's Democratic Republic (Laos), B...
  9. Liew F, Tay S, Puthucheary S. Reduced susceptibility of Malaysian clinical isolates of Burkholderia pseudomallei to ciprofloxacin. Trop Biomed. 2011;28:646-50 pubmed
    ..with good intracellular penetration may possibly be used for treatment of melioidosis caused by Burkholderia pseudomallei, but problems with resistance may be encountered...

More Information

Publications114 found, 100 shown here

  1. Judy B, Taylor K, Deeraksa A, Johnston R, Endsley J, Vijayakumar S, et al. Prophylactic application of CpG oligonucleotides augments the early host response and confers protection in acute melioidosis. PLoS ONE. 2012;7:e34176 pubmed publisher
    ..of CpG oligodeoxynucleotides (CpG ODNs) is known to confer protection against lethal sepsis caused by Burkholderia pseudomallei in the mouse model...
  2. Morris J, Williams N, Rush C, Govan B, Sangla K, Norton R, et al. Burkholderia pseudomallei triggers altered inflammatory profiles in a whole-blood model of type 2 diabetes-melioidosis comorbidity. Infect Immun. 2012;80:2089-99 pubmed publisher
    Melioidosis is a potentially fatal disease caused by the bacterium Burkholderia pseudomallei. Type 2 diabetes (T2D) is the most common comorbidity associated with melioidosis. B...
  3. Novem V, Shui G, Wang D, Bendt A, Sim S, Liu Y, et al. Structural and biological diversity of lipopolysaccharides from Burkholderia pseudomallei and Burkholderia thailandensis. Clin Vaccine Immunol. 2009;16:1420-8 pubmed publisher
    b>Burkholderia pseudomallei, the etiological agent of melioidosis, is a facultative intracellular pathogen. As B...
  4. Panomket P, Chetchotisakd P, Sermswan R, Pannengpetch P, Wongratanacheewin S. Use of a low-dose steroid as an adjunct in the treatment, in mice, of severe sepsis caused by Burkholderia pseudomallei. Ann Trop Med Parasitol. 2009;103:635-46 pubmed publisher
    Human melioidosis caused by Burkholderia pseudomallei is a severe septic disease that is associated with high mortality, even under appropriate antibiotic treatment...
  5. Draper A, Mayo M, Harrington G, Karp D, Yinfoo D, Ward L, et al. Association of the melioidosis agent Burkholderia pseudomallei with water parameters in rural water supplies in Northern Australia. Appl Environ Microbiol. 2010;76:5305-7 pubmed publisher
    We analyzed water parameters and the occurrence of the melioidosis agent Burkholderia pseudomallei in 47 water bores in Northern Australia. B. pseudomallei was associated with soft, acidic bore water of low salinity but high iron levels...
  6. Deris Z, Hasan H, Siti Suraiya M. Clinical characteristics and outcomes of bacteraemic melioidosis in a teaching hospital in a northeastern state of Malaysia: a five-year review. J Infect Dev Ctries. 2010;4:430-5 pubmed
    ..The wide range of clinical presentations and the fatal outcomes of melioidosis require a high level of suspicion among physicians to develop an early appropriate therapy and reduce the mortality rate. ..
  7. Moir D, Di M, Wong E, Moore R, Schweizer H, Woods D, et al. Development and application of a cellular, gain-of-signal, bioluminescent reporter screen for inhibitors of type II secretion in Pseudomonas aeruginosa and Burkholderia pseudomallei. J Biomol Screen. 2011;16:694-705 pubmed publisher
    ..In addition, seven of the nine compounds also inhibited the T2S-mediated extracellular secretion of phospholipase C by P. aeruginosa and protease activity by Burkholderia pseudomallei.
  8. Tunpiboonsak S, Mongkolrob R, Kitudomsub K, Thanwatanaying P, Kiettipirodom W, Tungboontina Y, et al. Role of a Burkholderia pseudomallei polyphosphate kinase in an oxidative stress response, motilities, and biofilm formation. J Microbiol. 2010;48:63-70 pubmed publisher
    b>Burkholderia pseudomallei, a motile and rod Gram-negative bacterium, is the causative agent of melioidosis...
  9. Gamage A, Shui G, Wenk M, Chua K. N-Octanoylhomoserine lactone signalling mediated by the BpsI-BpsR quorum sensing system plays a major role in biofilm formation of Burkholderia pseudomallei. Microbiology. 2011;157:1176-86 pubmed publisher
    The genome of Burkholderia pseudomallei encodes three acylhomoserine lactone (AHL) quorum sensing systems, each comprising an AHL synthase and a signal receptor/regulator...
  10. Zhang S, Feng S, Li B, Kim H, Rodriguez J, Tsai S, et al. In Vitro and In Vivo studies of monoclonal antibodies with prominent bactericidal activity against Burkholderia pseudomallei and Burkholderia mallei. Clin Vaccine Immunol. 2011;18:825-34 pubmed publisher
    Our laboratory has developed more than a hundred mouse monoclonal antibodies (MAbs) against Burkholderia pseudomallei and Burkholderia mallei...
  11. Baker A, Tahani D, Gardiner C, Bristow K, Greenhill A, Warner J. Groundwater seeps facilitate exposure to Burkholderia pseudomallei. Appl Environ Microbiol. 2011;77:7243-6 pubmed publisher
    b>Burkholderia pseudomallei is a saprophytic bacterium which is the causative agent of melioidosis, a common cause of fatal bacterial pneumonia and sepsis in the tropics...
  12. Cahn A, Koslowsky B, Nir Paz R, Temper V, Hiller N, Karlinsky A, et al. Imported melioidosis, Israel, 2008. Emerg Infect Dis. 2009;15:1809-11 pubmed publisher
    ..He had newly diagnosed diabetes mellitus, fever, multiple abscesses, and osteomyelitis. Burkholderia pseudomallei was isolated from urine and blood...
  13. Sarovich D, Price E, Von Schulze A, Cook J, Mayo M, Watson L, et al. Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from Australia. PLoS ONE. 2012;7:e30789 pubmed publisher
    b>Burkholderia pseudomallei is a gram-negative bacterium that causes the serious human disease, melioidosis...
  14. Woodman M, Worth R, Wooten R. Capsule influences the deposition of critical complement C3 levels required for the killing of Burkholderia pseudomallei via NADPH-oxidase induction by human neutrophils. PLoS ONE. 2012;7:e52276 pubmed publisher
    b>Burkholderia pseudomallei is the causative agent of melioidosis and is a major mediator of sepsis in its endemic areas...
  15. Songsri J, Proungvitaya T, Wongratanacheewin S, Homchampa P. Tn5-OT182 should not be used to identify genes involved in biofilm formation in Burkholderia pseudomallei. Southeast Asian J Trop Med Public Health. 2012;43:124-8 pubmed
    b>Burkholderia pseudomallei, a gram-negative bacterium, is the causative agent of melioidosis. One of the important virulence properties of this bacteria is its ability to form a biofilm. Genes involved in biofilm formation in B...
  16. Chen Y, Lin H, Mu J, Chiang C, Chen C, Buu L, et al. Distribution of melioidosis cases and viable Burkholderia pseudomallei in soil: evidence for emerging melioidosis in Taiwan. J Clin Microbiol. 2010;48:1432-4 pubmed publisher
    A survey for the prevalence if Burkholderia pseudomallei in soil in Taiwan found that its incidence is comparable to that in other regions of the world where melioidosis is endemic...
  17. Trung T, Hetzer A, Göhler A, Topfstedt E, Wuthiekanun V, Limmathurotsakul D, et al. Highly sensitive direct detection and quantification of Burkholderia pseudomallei bacteria in environmental soil samples by using real-time PCR. Appl Environ Microbiol. 2011;77:6486-94 pubmed publisher
    The soil bacterium and potential biothreat agent Burkholderia pseudomallei causes the infectious disease melioidosis, which is naturally acquired through environmental contact with the bacterium. Environmental detection of B...
  18. Behera B, Prasad Babu T, Kamalesh A, Reddy G. Ceftazidime resistance in Burkholderia pseudomallei: first report from India. Asian Pac J Trop Med. 2012;5:329-30 pubmed publisher
    ..Blood cultures and culture of the joint aspirate yielded pure growth of Burkholderia pseudomallei (B. pesudomallei), sensitive to carbapenem, co-trimoxazole and resistant to ceftazidime...
  19. Harris P, Engler C, Norton R. Comparative in vitro susceptibility of Burkholderia pseudomallei to doripenem, ertapenem, tigecycline and moxifloxacin. Int J Antimicrob Agents. 2011;37:547-9 pubmed publisher
    b>Burkholderia pseudomallei, the causative agent of melioidosis, continues to present therapeutic challenges in endemic areas. A number of clinical issues have prompted consideration of alternative antimicrobial therapies...
  20. Stewart T, Engelthaler D, Blaney D, Tuanyok A, Wangsness E, Smith T, et al. Epidemiology and investigation of melioidosis, Southern Arizona. Emerg Infect Dis. 2011;17:1286-8 pubmed publisher
    b>Burkholderia pseudomallei is a bacterium endemic to Southeast Asia and northern Australia, but it has not been found to occur endemically in the United States...
  21. Price E, Dale J, Cook J, Sarovich D, Seymour M, Ginther J, et al. Development and validation of Burkholderia pseudomallei-specific real-time PCR assays for clinical, environmental or forensic detection applications. PLoS ONE. 2012;7:e37723 pubmed publisher
    The bacterium Burkholderia pseudomallei causes melioidosis, a rare but serious illness that can be fatal if untreated or misdiagnosed. Species-specific PCR assays provide a technically simple method for differentiating B...
  22. Weissert C, Dollenmaier G, Rafeiner P, Riehm J, Schultze D. Burkholderia pseudomallei misidentified by automated system. Emerg Infect Dis. 2009;15:1799-801 pubmed publisher
    ..The organism was eventually identified by molecular methods as B. pseudomallei...
  23. Pearson T, Giffard P, Beckstrom Sternberg S, Auerbach R, Hornstra H, Tuanyok A, et al. Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer. BMC Biol. 2009;7:78 pubmed publisher
    ..gene transfer shows that the relative contributions of homologous recombination versus mutation for Burkholderia pseudomallei is over two times higher than for Streptococcus pneumoniae and is thus the highest value yet reported in ..
  24. Crow A, Race P, Jubelin G, Varela Chavez C, Escoubas J, Oswald E, et al. Crystal structures of Cif from bacterial pathogens Photorhabdus luminescens and Burkholderia pseudomallei. PLoS ONE. 2009;4:e5582 pubmed publisher
    ..insect pathogen/nematode symbiont Photorhabdus luminescens (a gamma-proteobacterium) and human pathogen Burkholderia pseudomallei (a beta-proteobacterium) are presented...
  25. Pankla R, Buddhisa S, Berry M, Blankenship D, Bancroft G, Banchereau J, et al. Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis. Genome Biol. 2009;10:R127 pubmed publisher
    Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, a Gram-negative bacillus classified by the National Institute of Allergy and Infectious Diseases (NIAID) as a category B priority agent...
  26. Bartpho T, Wongsurawat T, Wongratanacheewin S, Talaat A, Karoonuthaisiri N, Sermswan R. Genomic islands as a marker to differentiate between clinical and environmental Burkholderia pseudomallei. PLoS ONE. 2012;7:e37762 pubmed publisher
    b>Burkholderia pseudomallei, as a saprophytic bacterium that can cause a severe sepsis disease named melioidosis, has preserved several extra genes in its genome for survival...
  27. Lafontaine E, Zimmerman S, Shaffer T, Michel F, Gao X, Hogan R. Use of a safe, reproducible, and rapid aerosol delivery method to study infection by Burkholderia pseudomallei and Burkholderia mallei in mice. PLoS ONE. 2013;8:e76804 pubmed publisher
    b>Burkholderia pseudomallei, the etiologic agent of melioidosis, is a saprophytic bacterium readily isolated from wet soils of countries bordering the equator. Burkholderia mallei is a host-adapted clone of B...
  28. D Cruze T, Gong L, Treerat P, Ramm G, Boyce J, Prescott M, et al. Role for the Burkholderia pseudomallei type three secretion system cluster 1 bpscN gene in virulence. Infect Immun. 2011;79:3659-64 pubmed publisher
    b>Burkholderia pseudomallei, the causal agent of melioidosis, employs a number of virulence factors during its infection of mammalian cells...
  29. Dale J, Price E, Hornstra H, Busch J, Mayo M, Godoy D, et al. Epidemiological tracking and population assignment of the non-clonal bacterium, Burkholderia pseudomallei. PLoS Negl Trop Dis. 2011;5:e1381 pubmed publisher
    ..For non-clonal species such as Burkholderia pseudomallei, however, shared allelic states between distantly related isolates make it more difficult to identify ..
  30. Kaestli M, Richardson L, Colman R, Tuanyok A, Price E, Bowers J, et al. Comparison of TaqMan PCR assays for detection of the melioidosis agent Burkholderia pseudomallei in clinical specimens. J Clin Microbiol. 2012;50:2059-62 pubmed publisher
    Melioidosis is an emerging infectious disease caused by the soil bacterium Burkholderia pseudomallei. In diagnostic and forensic settings, molecular detection assays need not only high sensitivity with low limits of detection but also ..
  31. Wongprompitak P, Sirisinha S, Chaiyaroj S. Differential gene expression profiles of lung epithelial cells exposed to Burkholderia pseudomallei and Burkholderia thailandensis during the initial phase of infection. Asian Pac J Allergy Immunol. 2009;27:59-70 pubmed
    b>Burkholderia pseudomallei is the causative agent of melioidosis, and its infection usually affects patients' lungs...
  32. Ngugi S, Ventura V, Qazi O, Harding S, Kitto G, Estes D, et al. Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. Vaccine. 2010;28:7551-5 pubmed publisher
    Burkholderia thailandensis is a less virulent close relative of Burkholderia pseudomallei, a CDC category B biothreat agent. We have previously shown that lipopolysaccharide (LPS) extracted from B...
  33. Nieves W, Heang J, Asakrah S, Honer zu Bentrup K, Roy C, Morici L. Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization. PLoS ONE. 2010;5:e14361 pubmed publisher
    b>Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in parts of Southeast Asia and Northern Australia. Currently there is no licensed vaccine against infection with this biological threat agent...
  34. Begley D, Hartley R, Davies D, Edwards T, Leonard J, Abendroth J, et al. Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. J Struct Funct Genomics. 2011;12:63-76 pubmed publisher
    ..structure determination results for 2C-methyl-D-erythritol-2,4-cyclo-diphosphate (MECP) synthase from Burkholderia pseudomallei, the gram-negative bacterium which causes melioidosis...
  35. Riyapa D, Buddhisa S, Korbsrisate S, Cuccui J, Wren B, Stevens M, et al. Neutrophil extracellular traps exhibit antibacterial activity against burkholderia pseudomallei and are influenced by bacterial and host factors. Infect Immun. 2012;80:3921-9 pubmed publisher
    b>Burkholderia pseudomallei is the causative pathogen of melioidosis, of which a major predisposing factor is diabetes mellitus...
  36. Karger A, Stock R, Ziller M, Elschner M, Bettin B, Melzer F, et al. Rapid identification of Burkholderia mallei and Burkholderia pseudomallei by intact cell Matrix-assisted Laser Desorption/Ionisation mass spectrometric typing. BMC Microbiol. 2012;12:229 pubmed publisher
    ..When a dedicated reference set is used and spectra of high quality are acquired, it is possible to distinguish both species unambiguously. The need for a careful curation of reference spectra databases is stressed. ..
  37. Kayath C, Hussey S, El hajjami N, Nagra K, Philpott D, Allaoui A. Escape of intracellular Shigella from autophagy requires binding to cholesterol through the type III effector, IcsB. Microbes Infect. 2010;12:956-66 pubmed publisher
    ..Furthermore, we report that BopA, the counterpart of IcsB in Burkholderia pseudomallei with similar autophagy-evading properties, contains the CBD domain and is also able to bind cholesterol.
  38. Khoo J, Chai S, Mohamed R, Nathan S, Firdaus Raih M. Computational discovery and RT-PCR validation of novel Burkholderia conserved and Burkholderia pseudomallei unique sRNAs. BMC Genomics. 2012;13 Suppl 7:S13 pubmed publisher
    ..It is expected that sRNAs may also have similar functions for Burkholderia pseudomallei, a soil bacterium that can adapt to diverse environmental conditions, which causes the disease ..
  39. Lee S, Wong R, Chin C, Lim T, Eng S, Kong C, et al. Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor. Proc Natl Acad Sci U S A. 2013;110:15067-72 pubmed publisher
    b>Burkholderia pseudomallei is a Gram-negative soil bacterium that infects both humans and animals...
  40. Chantratita N, Tandhavanant S, Wongsuvan G, Wuthiekanun V, Teerawattanasook N, Day N, et al. Rapid detection of Burkholderia pseudomallei in blood cultures using a monoclonal antibody-based immunofluorescent assay. Am J Trop Med Hyg. 2013;89:971-2 pubmed publisher
    Melioidosis is a severe bacterial infection caused by Burkholderia pseudomallei. Rapid antimicrobial therapy is necessary to improve patient outcome, which is aided by direct detection of B. pseudomallei in clinical samples...
  41. Su Y, Wan K, Mohamed R, Nathan S. Immunization with the recombinant Burkholderia pseudomallei outer membrane protein Omp85 induces protective immunity in mice. Vaccine. 2010;28:5005-11 pubmed publisher
    b>Burkholderia pseudomallei is resistant to a wide range of antibiotics, leading to relapse and recrudescence of melioidosis after cessation of antibiotic therapy...
  42. Burtnick M, Brett P, Harding S, Ngugi S, Ribot W, Chantratita N, et al. The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 2011;79:1512-25 pubmed publisher
    The Burkholderia pseudomallei K96243 genome encodes six type VI secretion systems (T6SSs), but little is known about the role of these systems in the biology of B. pseudomallei...
  43. Revelli D, Boylan J, Gherardini F. A non-invasive intratracheal inoculation method for the study of pulmonary melioidosis. Front Cell Infect Microbiol. 2012;2:164 pubmed publisher
    Pulmonary melioidosis, a disease manifestation caused by the bacterium Burkholderia pseudomallei, has been studied using aerosols or intranasal (IN) inoculation in small animal models...
  44. Larsen J, Johnson N. Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei. Mil Med. 2009;174:647-51 pubmed
    b>Burkholderia pseudomallei and mallei are biological agents of military significance. There has been significant research in recent years to develop medical countermeasures for these organisms...
  45. Balder R, Lipski S, Lazarus J, Grose W, Wooten R, Hogan R, et al. Identification of Burkholderia mallei and Burkholderia pseudomallei adhesins for human respiratory epithelial cells. BMC Microbiol. 2010;10:250 pubmed publisher
    b>Burkholderia pseudomallei and Burkholderia mallei cause the diseases melioidosis and glanders, respectively...
  46. Williams N, Morris J, Rush C, Govan B, Ketheesan N. Impact of streptozotocin-induced diabetes on functional responses of dendritic cells and macrophages towards Burkholderia pseudomallei. FEMS Immunol Med Microbiol. 2011;61:218-27 pubmed publisher
    Diabetes mellitus is a documented risk factor for melioidosis, a tropical infection caused by Burkholderia pseudomallei. The increased susceptibility of diabetic individuals to infections with other pathogens has been associated with ..
  47. Henderson A, Propst K, Kedl R, Dow S. Mucosal immunization with liposome-nucleic acid adjuvants generates effective humoral and cellular immunity. Vaccine. 2011;29:5304-12 pubmed publisher
    ..vaccine adjuvanted with CLDC induced significant protection from lethal pulmonary challenge with Burkholderia pseudomallei. These findings suggest that liposome-nucleic acid adjuvants represent a promising new class of mucosal ..
  48. Pumpuang A, Chantratita N, Wikraiphat C, Saiprom N, Day N, Peacock S, et al. Survival of Burkholderia pseudomallei in distilled water for 16 years. Trans R Soc Trop Med Hyg. 2011;105:598-600 pubmed publisher
    b>Burkholderia pseudomallei was examined after being maintained in distilled water at 25°C for 16 years. The Gram stain was atypical (pale pink cocci or coccobacilli). The estimated number of live and dead B. pseudomallei was 3...
  49. Wuthiekanun V, Amornchai P, Saiprom N, Chantratita N, Chierakul W, Koh G, et al. Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand. Antimicrob Agents Chemother. 2011;55:5388-91 pubmed publisher
    ..Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis...
  50. Richardson L, Kaestli M, Mayo M, Bowers J, Tuanyok A, Schupp J, et al. Towards a rapid molecular diagnostic for melioidosis: Comparison of DNA extraction methods from clinical specimens. J Microbiol Methods. 2012;88:179-81 pubmed publisher
    Optimising DNA extraction from clinical samples for Burkholderia pseudomallei Type III secretion system real-time PCR in suspected melioidosis patients confirmed that urine and sputum are useful diagnostic samples...
  51. Brilhante R, Valente L, Rocha M, Bandeira T, Cordeiro R, Lima R, et al. Sesquiterpene farnesol contributes to increased susceptibility to ?-lactams in strains of Burkholderia pseudomallei. Antimicrob Agents Chemother. 2012;56:2198-200 pubmed publisher
    This study aimed to evaluate the in vitro combination of farnesol and ?-lactams against Burkholderia pseudomallei. A total of 12 ?-lactamase-positive strains were tested according to CLSI standards...
  52. Campos C, Borst L, Cotter P. Characterization of BcaA, a putative classical autotransporter protein in Burkholderia pseudomallei. Infect Immun. 2013;81:1121-8 pubmed publisher
    b>Burkholderia pseudomallei is a tier 1 select agent, and the causative agent of melioidosis, a disease with effects ranging from chronic abscesses to fulminant pneumonia and septic shock, which can be rapidly fatal...
  53. Lee Y, Chen Y, Ouyang X, Gan Y. Identification of tomato plant as a novel host model for Burkholderia pseudomallei. BMC Microbiol. 2010;10:28 pubmed publisher
    b>Burkholderia pseudomallei is the causative agent for melioidosis, a disease with significant mortality and morbidity in endemic regions. Its versatility as a pathogen is reflected in its relatively huge 7...
  54. Sun G, Gan Y. Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei. Trends Microbiol. 2010;18:561-8 pubmed publisher
    b>Burkholderia pseudomallei is a highly versatile pathogen capable of infecting many species of animals and plants...
  55. Mima T, Schweizer H, Xu Z. In vitro activity of cethromycin against Burkholderia pseudomallei and investigation of mechanism of resistance. J Antimicrob Chemother. 2011;66:73-8 pubmed publisher
    most Burkholderia pseudomallei strains are intrinsically resistant to macrolides, mainly due to AmrAB-OprA- and/or BpeAB-OprB-mediated efflux. We assessed the in vitro anti-B...
  56. Mukhopadhyay C, Kaestli M, Vandana K, Sushma K, Mayo M, Richardson L, et al. Molecular characterization of clinical Burkholderia pseudomallei isolates from India. Am J Trop Med Hyg. 2011;85:121-3 pubmed publisher
    Multilocus sequence typing of seven isolates of Burkholderia pseudomallei from India showed considerable diversity, with six different sequence types...
  57. Kanthawong S, Bolscher J, Veerman E, van Marle J, de Soet H, Nazmi K, et al. Antimicrobial and antibiofilm activity of LL-37 and its truncated variants against Burkholderia pseudomallei. Int J Antimicrob Agents. 2012;39:39-44 pubmed publisher
    The Gram-negative bacterium Burkholderia pseudomallei is the aetiological agent of melioidosis, which is an endemic disease in tropical areas of Southeast Asia and Northern Australia...
  58. Madhongsa K, Pasan S, Phophetleb O, Nasompag S, Thammasirirak S, Daduang S, et al. Antimicrobial action of the cyclic peptide bactenecin on Burkholderia pseudomallei correlates with efficient membrane permeabilization. PLoS Negl Trop Dis. 2013;7:e2267 pubmed publisher
    b>Burkholderia pseudomallei is a category B agent that causes Melioidosis, an acute and chronic disease with septicemia...
  59. Ooi W, Ong C, Nandi T, Kreisberg J, Chua H, Sun G, et al. The condition-dependent transcriptional landscape of Burkholderia pseudomallei. PLoS Genet. 2013;9:e1003795 pubmed publisher
    b>Burkholderia pseudomallei (Bp), the causative agent of the often-deadly infectious disease melioidosis, contains one of the largest prokaryotic genomes sequenced to date, at 7.2 Mb with two large circular chromosomes (1 and 2)...
  60. Mima T, Schweizer H. The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. Antimicrob Agents Chemother. 2010;54:3113-20 pubmed publisher
    Most Burkholderia pseudomallei strains are intrinsically aminoglycoside resistant, mainly due to AmrAB-OprA-mediated efflux...
  61. Galyov E, Brett P, DeShazer D. Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis. Annu Rev Microbiol. 2010;64:495-517 pubmed publisher
    b>Burkholderia pseudomallei and Burkholderia mallei are closely related gram-negative bacteria that can cause serious diseases in humans and animals...
  62. Phewkliang A, Wongratanacheewin S, Chareonsudjai S. Role of Burkholderia pseudomallei in the invasion, replication and induction of apoptosis in human epithelial cell lines. Southeast Asian J Trop Med Public Health. 2010;41:1164-76 pubmed
    b>Burkholderia pseudomallei is a bacterial pathogen causing melioidosis. In the present study, we demonstrated the effects of B...
  63. Suginta W, Mahendran K, Chumjan W, Hajjar E, Schulte A, Winterhalter M, et al. Molecular analysis of antimicrobial agent translocation through the membrane porin BpsOmp38 from an ultraresistant Burkholderia pseudomallei strain. Biochim Biophys Acta. 2011;1808:1552-9 pubmed publisher
    b>Burkholderia pseudomallei (Bps) is a Gram-negative bacterium that causes melioidosis, an infectious disease of animals and humans common in northern and north-eastern parts of Thailand...
  64. Breitbach K, Wongprompitak P, Steinmetz I. Distinct roles for nitric oxide in resistant C57BL/6 and susceptible BALB/c mice to control Burkholderia pseudomallei infection. BMC Immunol. 2011;12:20 pubmed publisher
    b>Burkholderia pseudomallei is the causative agent of melioidosis, an emerging bacterial infectious disease in tropical and subtropical areas...
  65. Nikolakakis K, Amber S, Wilbur J, Diner E, Aoki S, Poole S, et al. The toxin/immunity network of Burkholderia pseudomallei contact-dependent growth inhibition (CDI) systems. Mol Microbiol. 2012;84:516-29 pubmed publisher
    b>Burkholderia pseudomallei is a category B pathogen and the causative agent of melioidosis--a serious infectious disease that is typically acquired directly from environmental reservoirs. Nearly all B...
  66. Butt A, Müller C, Harmer N, Titball R. Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiol Lett. 2013;338:86-94 pubmed publisher
    ..We have identified eight candidate TA systems in the genome of the human pathogen Burkholderia pseudomallei. Five of these were located in genome islands...
  67. Asakrah S, Nieves W, Mahdi Z, Agard M, Zea A, Roy C, et al. Post-exposure therapeutic efficacy of COX-2 inhibition against Burkholderia pseudomallei. PLoS Negl Trop Dis. 2013;7:e2212 pubmed publisher
    b>Burkholderia pseudomallei is a Gram-negative, facultative intracellular bacillus and the etiologic agent of melioidosis, a severe disease in Southeast Asia and Northern Australia...
  68. Chan Y, Chua K. Growth-related changes in intracellular spermidine and its effect on efflux pump expression and quorum sensing in Burkholderia pseudomallei. Microbiology. 2010;156:1144-54 pubmed publisher
    The Burkholderia pseudomallei BpeAB-OprB resistance-nodulation-division (RND) family pump effluxes aminoglycoside and macrolide antibiotics as well as acylhomoserine lactones (AHLs) involved in quorum sensing...
  69. Tan K, Chen Y, Lim Y, Tan G, Liu Y, Lim Y, et al. Suppression of host innate immune response by Burkholderia pseudomallei through the virulence factor TssM. J Immunol. 2010;184:5160-71 pubmed publisher
    b>Burkholderia pseudomallei is a Gram-negative saprophyte that is the causative agent of melioidosis, a severe infectious disease endemic in Northern Australia and Southeast Asia...
  70. Harmer N. The structure of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei reveals a zinc binding site at the heart of the active site. J Mol Biol. 2010;400:379-92 pubmed publisher
    ..Here, the structure of GmhA from Burkholderia pseudomallei is reported...
  71. Pagnarith Y, Kumar V, Thaipadungpanit J, Wuthiekanun V, Amornchai P, Sin L, et al. Emergence of pediatric melioidosis in Siem Reap, Cambodia. Am J Trop Med Hyg. 2010;82:1106-12 pubmed publisher
    ..Our findings indicate the need for heightened awareness of melioidosis in Cambodia, and they have led us to review microbiology procedures and antimicrobial prescribing of suspected and confirmed cases...
  72. Tandhavanant S, Thanwisai A, Limmathurotsakul D, Korbsrisate S, Day N, Peacock S, et al. Effect of colony morphology variation of Burkholderia pseudomallei on intracellular survival and resistance to antimicrobial environments in human macrophages in vitro. BMC Microbiol. 2010;10:303 pubmed publisher
    ..from patients with melioidosis demonstrate variation in colony morphology of the causative organism, Burkholderia pseudomallei. Variable morphology is associated with changes in the expression of a range of putative virulence ..
  73. Wongtrakoongate P, Roytrakul S, Yasothornsrikul S, Tungpradabkul S. A proteome reference map of the causative agent of melioidosis Burkholderia pseudomallei. J Biomed Biotechnol. 2011;2011:530926 pubmed publisher
    b>Burkholderia pseudomallei is the etiologic agent of melioidosis. Using 2DE and MALDI-TOF MS, we report here a proteome reference map constructed from early stationary phase, a bacterial adaptation process...
  74. Skyberg J, Rollins M, Holderness J, Marlenee N, Schepetkin I, Goodyear A, et al. Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections. PLoS Pathog. 2012;8:e1002587 pubmed publisher
    Pulmonary Francisella tularensis and Burkholderia pseudomallei infections are highly lethal in untreated patients, and current antibiotic regimens are not always effective...
  75. Thomas R, Davies C, Nunez A, Hibbs S, Eastaugh L, Harding S, et al. Particle-size dependent effects in the Balb/c murine model of inhalational melioidosis. Front Cell Infect Microbiol. 2012;2:101 pubmed publisher
    Deposition of Burkholderia pseudomallei within either the lungs or nasal passages of the Balb/c murine model resulted in different infection kinetics. The infection resulting from the inhalation of B...
  76. Felgner P, Kayala M, VIGIL A, Burk C, Nakajima Sasaki R, Pablo J, et al. A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens. Proc Natl Acad Sci U S A. 2009;106:13499-504 pubmed publisher
    ..To provide insight into this area, we fabricated a protein microarray containing 1,205 Burkholderia pseudomallei proteins, probed it with 88 melioidosis patient sera, and identified 170 reactive antigens...
  77. Warawa J, Long D, Rosenke R, Gardner D, Gherardini F. Role for the Burkholderia pseudomallei capsular polysaccharide encoded by the wcb operon in acute disseminated melioidosis. Infect Immun. 2009;77:5252-61 pubmed publisher
    The capsular polysaccharide of Burkholderia pseudomallei is an essential virulence determinant that is required for protection from host serum cidal activity and opsonophagocytosis. In this study, the immune response directed against a B...
  78. Ireland R, Olivares Zavaleta N, Warawa J, Gherardini F, Jarrett C, Hinnebusch B, et al. Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens. PLoS Pathog. 2010;6:e1000921 pubmed publisher
    ..Lastly, CLDC+MPF was also effective at controlling infections with Yersinia pestis, Burkholderia pseudomallei and Brucella abortus...
  79. Biggins J, Liu X, Feng Z, Brady S. Metabolites from the induced expression of cryptic single operons found in the genome of Burkholderia pseudomallei. J Am Chem Soc. 2011;133:1638-41 pubmed publisher
    ..potential single-operon biosynthetic systems found in the genome of the pathogenic bacterium Burkholderia pseudomallei ...
  80. Trung T, Hetzer A, Topfstedt E, Göhler A, Limmathurotsakul D, Wuthiekanun V, et al. Improved culture-based detection and quantification of Burkholderia pseudomallei from soil. Trans R Soc Trop Med Hyg. 2011;105:346-51 pubmed publisher
    Environmental surveillance of the Gram-negative soil bacterium Burkholderia pseudomallei, the aetiological agent of melioidosis, is important in order to define human populations and livestock at risk of acquiring the infection...
  81. Engelthaler D, Bowers J, Schupp J, Pearson T, Ginther J, Hornstra H, et al. Molecular investigations of a locally acquired case of melioidosis in Southern AZ, USA. PLoS Negl Trop Dis. 2011;5:e1347 pubmed publisher
    Melioidosis is caused by Burkholderia pseudomallei, a Gram-negative bacillus, primarily found in soils in Southeast Asia and northern Australia...
  82. Muangman S, Korbsrisate S, Muangsombut V, Srinon V, Adler N, Schroeder G, et al. BopC is a type III secreted effector protein of Burkholderia pseudomallei. FEMS Microbiol Lett. 2011;323:75-82 pubmed publisher
    b>Burkholderia pseudomallei, the causative agent of melioidosis, exploits the Bsa type III secretion system (T3SS) to deliver effector proteins into host cells...
  83. Puangpetch A, Anderson R, Huang Y, Sermswan R, Chaicumpa W, Sirisinha S, et al. Cationic liposomes extend the immunostimulatory effect of CpG oligodeoxynucleotide against Burkholderia pseudomallei infection in BALB/c mice. Clin Vaccine Immunol. 2012;19:675-83 pubmed publisher
    Melioidosis is a severe disease caused by the Gram-negative bacterium Burkholderia pseudomallei. Previously we showed that pretreatment of mice with CpG oligodeoxynucleotide (CpG ODN) 2 to 10 days prior to B...
  84. Liew S, Tay S, Wongratanacheewin S, Puthucheary S. Enzymatic profiling of clinical and environmental isolates of Burkholderia pseudomallei. Trop Biomed. 2012;29:160-8 pubmed
    ..The disease caused by an environmental saprophyte Burkholderia pseudomallei, affects mostly adults with underlying immunocompromised conditions...
  85. Hayden H, Lim R, Brittnacher M, Sims E, Ramage E, Fong C, et al. Evolution of Burkholderia pseudomallei in recurrent melioidosis. PLoS ONE. 2012;7:e36507 pubmed publisher
    b>Burkholderia pseudomallei, the etiologic agent of human melioidosis, is capable of causing severe acute infection with overwhelming septicemia leading to death...
  86. Bandeira T, Moreira C, Brilhante R, Castelo Branco D, Neto M, Cordeiro R, et al. In vitro activities of amoxicillin-clavulanate, doxycycline, ceftazidime, imipenem, and trimethoprim-sulfamethoxazole against biofilm of Brazilian strains of Burkholderia pseudomallei. Antimicrob Agents Chemother. 2013;57:5771-3 pubmed publisher
    ..amoxicillin-clavulanate, doxycycline, ceftazidime, imipenem, and trimethoprim-sulfamethoxazole against Burkholderia pseudomallei in planktonic and biofilm forms, through broth microdilution and resazurin-based viability staining, ..
  87. Silva E, Goodyear A, Sutherland M, Podnecky N, Gonzalez Juarrero M, Schweizer H, et al. Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine. Infect Immun. 2013;81:4626-34 pubmed publisher
    Infections with the Gram-negative bacterium Burkholderia pseudomallei (melioidosis) are associated with high mortality, and there is currently no approved vaccine to prevent the development of melioidosis in humans...
  88. Koh S, Tay S, Puthucheary S. Colonial morphotypes and biofilm forming ability of Burkholderia pseudomallei. Trop Biomed. 2013;30:428-33 pubmed
    b>Burkholderia pseudomallei the causative agent of melioidosis, is being increasingly recognized as an important cause of morbidity and mortality in South East Asia. Biofilm formation of B...
  89. Wikraiphat C, Charoensap J, Utaisincharoen P, Wongratanacheewin S, Taweechaisupapong S, Woods D, et al. Comparative in vivo and in vitro analyses of putative virulence factors of Burkholderia pseudomallei using lipopolysaccharide, capsule and flagellin mutants. FEMS Immunol Med Microbiol. 2009;56:253-9 pubmed publisher
    b>Burkholderia pseudomallei is a gram-negative bacillus that is the causative agent of melioidosis. We evaluated host-pathogen interaction at different levels using three separate B...
  90. Buchko G, Robinson H, Abendroth J, Staker B, Myler P. Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state. Biochem Biophys Res Commun. 2010;394:1012-7 pubmed publisher
    ..Here we report the 2.1A resolution crystal structure for the 220-residue Adk from Burkholderia pseudomallei (BpAdk), the etiological agent responsible for the infectious disease melioidosis...
  91. Hamad M, Austin C, Stewart A, Higgins M, Vazquez Torres A, Voskuil M. Adaptation and antibiotic tolerance of anaerobic Burkholderia pseudomallei. Antimicrob Agents Chemother. 2011;55:3313-23 pubmed publisher
    The Gram-negative bacterium Burkholderia pseudomallei is the etiological agent of melioidosis and is remarkably resistant to most classes of antibacterials...
  92. Vanaporn M, Wand M, Michell S, Sarkar Tyson M, Ireland P, Goldman S, et al. Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei. Microbiology. 2011;157:2392-400 pubmed publisher
    b>Burkholderia pseudomallei is an intracellular pathogen and the causative agent of melioidosis, a life-threatening disease of humans. Within host cells, superoxide is an important mediator of pathogen killing...