burkholderia cepacia complex

Summary

Summary: A group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents.

Top Publications

  1. Reik R, Spilker T, LiPuma J. Distribution of Burkholderia cepacia complex species among isolates recovered from persons with or without cystic fibrosis. J Clin Microbiol. 2005;43:2926-8 pubmed
    We analyzed Burkholderia cepacia complex isolates recovered from 1,218 cystic fibrosis (CF) patients and 90 patients without CF. Although all B. cepacia complex species were found, some were rarely identified...
  2. Sousa S, Ulrich M, Bragonzi A, Burke M, Worlitzsch D, Leitão J, et al. Virulence of Burkholderia cepacia complex strains in gp91phox-/- mice. Cell Microbiol. 2007;9:2817-25 pubmed
    In cystic fibrosis (CF), infection with Burkholderia cepacia complex (Bcc) strains may cause long-term asymptomatic airway colonization, or severe lung infection leading to rapid pulmonary decline...
  3. Goudie A, Lynch K, Seed K, Stothard P, Shrivastava S, Wishart D, et al. Genomic sequence and activity of KS10, a transposable phage of the Burkholderia cepacia complex. BMC Genomics. 2008;9:615 pubmed publisher
    The Burkholderia cepacia complex (BCC) is a versatile group of Gram negative organisms that can be found throughout the environment in sources such as soil, water, and plants...
  4. Zlosnik J, Speert D. The role of mucoidy in virulence of bacteria from the Burkholderia cepacia complex: a systematic proteomic and transcriptomic analysis. J Infect Dis. 2010;202:770-81 pubmed publisher
    Bacteria of the Burkholderia cepacia complex (BCC) are associated with severe infection in cystic fibrosis...
  5. Meghdas I, Loiez C, Baida N, Dabboussi F, Hamze M, Husson M, et al. [Epidemiology of infections associated to "Burkholderia cepacia complex" in the course of cystic fibrosis]. Arch Pediatr. 2004;11:360-6 pubmed
    ..The identification of these new species appears particularly difficult and, by the fact, the data on taxonomy and molecular epidemiology can be provided only by highly specialized reference centers. ..
  6. Uehlinger S, Schwager S, Bernier S, Riedel K, Nguyen D, Sokol P, et al. Identification of specific and universal virulence factors in Burkholderia cenocepacia strains by using multiple infection hosts. Infect Immun. 2009;77:4102-10 pubmed publisher
    Over the past few decades, strains of the Burkholderia cepacia complex have emerged as important pathogens for patients suffering from cystic fibrosis...
  7. Maloney K, Valvano M. The mgtC gene of Burkholderia cenocepacia is required for growth under magnesium limitation conditions and intracellular survival in macrophages. Infect Immun. 2006;74:5477-86 pubmed
  8. Conway B, Chu K, Bylund J, Altman E, Speert D. Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice. J Infect Dis. 2004;190:957-66 pubmed
    Despite the characterization of some Burkholderia cepacia complex exopolysaccharides (EPSs), little is known about the role of EPSs in the pathogenicity of B. cepacia complex organisms...
  9. Mott T, Soler M, Grigsby S, Medley R, Whitlock G. Identification of potential diagnostic markers among Burkholderia cenocepacia and B. multivorans supernatants. J Clin Microbiol. 2010;48:4186-92 pubmed publisher
    ..Among them, the Burkholderia cepacia complex (Bcc) bacteria, consisting of nine related species, have emerged as problematic CF pathogens due to ..

More Information

Publications96

  1. Flannagan R, Aubert D, Kooi C, Sokol P, Valvano M. Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo. Infect Immun. 2007;75:1679-89 pubmed
    ..Together, our data demonstrate that HtrA(BCAL2829) is a virulence factor in B. cenocepacia. ..
  2. Tabacchioni S, Ferri L, Manno G, Mentasti M, Cocchi P, Campana S, et al. Use of the gyrB gene to discriminate among species of the Burkholderia cepacia complex. FEMS Microbiol Lett. 2008;281:175-82 pubmed publisher
    Bacteria of the Burkholderia cepacia complex (Bcc) are opportunistic pathogens that can cause serious infections in lungs of cystic fibrosis patients...
  3. Yang J, Spilker T, LiPuma J. Simultaneous coinfection by multiple strains during Burkholderia cepacia complex infection in cystic fibrosis. Diagn Microbiol Infect Dis. 2006;54:95-8 pubmed
    Much remains unknown about the natural history of respiratory tract infection by Burkholderia cepacia complex (Bcc) in persons with cystic fibrosis (CF)...
  4. Coenye T. Social interactions in the Burkholderia cepacia complex: biofilms and quorum sensing. Future Microbiol. 2010;5:1087-99 pubmed publisher
    b>Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B...
  5. Drevinek P, Vosahlikova S, Dedeckova K, Cinek O, Mahenthiralingam E. Direct culture-independent Strain typing of Burkholderia cepacia complex in sputum samples from patients with cystic fibrosis. J Clin Microbiol. 2010;48:1888-91 pubmed publisher
    We examined if multilocus sequence typing (MLST), a method for genotyping and species identification of Burkholderia cepacia complex bacteria, could be applied directly to cystic fibrosis sputum...
  6. Seed K, Dennis J. Experimental bacteriophage therapy increases survival of Galleria mellonella larvae infected with clinically relevant strains of the Burkholderia cepacia complex. Antimicrob Agents Chemother. 2009;53:2205-8 pubmed publisher
    The Burkholderia cepacia complex (BCC) is a group of bacterial pathogens that are highly antibiotic resistant and associated with debilitating respiratory infections...
  7. Olland A, Falcoz P, Kessler R, Massard G. Should cystic fibrosis patients infected with Burkholderia cepacia complex be listed for lung transplantation?. Interact Cardiovasc Thorac Surg. 2011;13:631-4 pubmed publisher
    ..remained a beneficial treatment for cystic fibrosis (CF) patients infected or colonized with Burkholderia cepacia complex (BCC) prior to lung transplantation (LTx)...
  8. Middleton P, Kidd T, Williams B. Combination aerosol therapy to treat Burkholderia cepacia complex. Eur Respir J. 2005;26:305-8 pubmed
    ..Furthermore, the strategy of combining antibiotics with ion transport agents may have ramifications for the treatment of other multi-resistant organisms. ..
  9. Mahenthiralingam E, Vandamme P. Taxonomy and pathogenesis of the Burkholderia cepacia complex. Chron Respir Dis. 2005;2:209-17 pubmed
    ..The Burkholderia cepacia complex bacteria are problematic CF pathogens because (i) they are very resistant to antibiotics, making ..
  10. Lynch K, Stothard P, Dennis J. Characterization of DC1, a broad-host-range Bcep22-like podovirus. Appl Environ Microbiol. 2012;78:889-91 pubmed publisher
    ..We have isolated and characterized a novel member of this group named DC1. This podovirus shows many genomic similarities to BcepIL02 and Bcep22, but it infects strains belonging to multiple Burkholderia cepacia complex (BCC) species.
  11. Lamothe J, Thyssen S, Valvano M. Burkholderia cepacia complex isolates survive intracellularly without replication within acidic vacuoles of Acanthamoeba polyphaga. Cell Microbiol. 2004;6:1127-38 pubmed
    We have previously demonstrated that isolates of the Burkholderia cepacia complex can survive intracellularly in murine macrophages and in free-living Acanthamoeba. In this work, we show that the clinical isolates B...
  12. Drevinek P, Vosahlikova S, Cinek O, Vavrova V, Bartosova J, Pohunek P, et al. Widespread clone of Burkholderia cenocepacia in cystic fibrosis patients in the Czech Republic. J Med Microbiol. 2005;54:655-9 pubmed
    ..and mortality rates in patients with cystic fibrosis (CF) are significantly affected by infections with Burkholderia cepacia complex. In a Czech CF Centre, the prevalence of the infection reached up to 30 %, with the majority of ..
  13. Lucero C, Cohen A, Trevino I, Rupp A, Harris M, Forkan Kelly S, et al. Outbreak of Burkholderia cepacia complex among ventilated pediatric patients linked to hospital sinks. Am J Infect Control. 2011;39:775-8 pubmed publisher
    We investigated a cluster of Burkholderia cepacia complex colonization in ventilated pediatric patients. Isolates from 15 patients, 2 sink drains, and several ventilator components were found to belong to a single B cenocepacia clone...
  14. Vanlaere E, Baldwin A, Gevers D, Henry D, De Brandt E, LiPuma J, et al. Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov. Int J Syst Evol Microbiol. 2009;59:102-11 pubmed publisher
    ..was to re-examine the taxonomic position and structure of taxon K (also known as group K) within the Burkholderia cepacia complex (Bcc)...
  15. Zlosnik J, Hird T, Fraenkel M, Moreira L, Henry D, Speert D. Differential mucoid exopolysaccharide production by members of the Burkholderia cepacia complex. J Clin Microbiol. 2008;46:1470-3 pubmed publisher
    We demonstrate that all nine species of the Burkholderia cepacia complex can express the mucoid phenotype. A survey of clinical isolates showed that strains of B...
  16. Leitão J, Sousa S, Cunha M, Salgado M, Melo Cristino J, Barreto M, et al. Variation of the antimicrobial susceptibility profiles of Burkholderia cepacia complex clonal isolates obtained from chronically infected cystic fibrosis patients: a five-year survey in the major Portuguese treatment center. Eur J Clin Microbiol Infect Dis. 2008;27:1101-11 pubmed publisher
    The treatment of cystic fibrosis (CF) patients chronically infected with Burkholderia cepacia complex (Bcc) bacteria requires extensive and aggressive antibiotics therapy, exposing these bacteria to prolonged antibiotics-selective ..
  17. Saldías M, Lamothe J, Wu R, Valvano M. Burkholderia cenocepacia requires the RpoN sigma factor for biofilm formation and intracellular trafficking within macrophages. Infect Immun. 2008;76:1059-67 pubmed publisher
    ..cenocepacia is involved in delaying phagolysosomal fusion, thereby prolonging bacterial intracellular survival within macrophages. ..
  18. Drevinek P, Mahenthiralingam E. Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence. Clin Microbiol Infect. 2010;16:821-30 pubmed publisher
    b>Burkholderia cepacia complex (Bcc) bacteria have gained notoriety as pathogens in cystic fibrosis (CF) because they are difficult to identify and treat, and also have the ability to spread between CF individuals...
  19. Gingues S, Kooi C, Visser M, Subsin B, Sokol P. Distribution and expression of the ZmpA metalloprotease in the Burkholderia cepacia complex. J Bacteriol. 2005;187:8247-55 pubmed
    The distribution of the metalloprotease gene zmpA was determined among strains of the Burkholderia cepacia complex (Bcc). The zmpA gene was present in B. cepacia, B. cenocepacia, B. stabilis, B. ambifaria and B...
  20. Brisse S, Cordevant C, Vandamme P, Bidet P, Loukil C, Chabanon G, et al. Species distribution and ribotype diversity of Burkholderia cepacia complex isolates from French patients with cystic fibrosis. J Clin Microbiol. 2004;42:4824-7 pubmed
    ..B. multivorans genotype A (found in 32 French patients) and two other genotypes were also identified among isolates from Austrian, German, Italian, and Canadian patients. ..
  21. Deng Y, Wu J, Eberl L, Zhang L. Structural and functional characterization of diffusible signal factor family quorum-sensing signals produced by members of the Burkholderia cepacia complex. Appl Environ Microbiol. 2010;76:4675-83 pubmed publisher
    ..In this study, we determined whether C(12):Delta(2) production is conserved in other members of the Burkholderia cepacia complex (Bcc) by using a combination of high-performance liquid chromatography, mass spectrometry, and ..
  22. Lynch K, Dennis J. Cangene gold medal award lecture - Genomic analysis and modification of Burkholderia cepacia complex bacteriophages. Can J Microbiol. 2012;58:221-35 pubmed publisher
    ..Both the genomic characterization and subsequent engineering of Bcc-specific phages are fundamental to the development of an effective phage therapy strategy for these bacteria. ..
  23. Vandamme P, Dawyndt P. Classification and identification of the Burkholderia cepacia complex: Past, present and future. Syst Appl Microbiol. 2011;34:87-95 pubmed publisher
    The Burkholderia cepacia complex is a group of closely related species with conflicting biological properties...
  24. Campana S, Taccetti G, Ravenni N, Favari F, Cariani L, Sciacca A, et al. Transmission of Burkholderia cepacia complex: evidence for new epidemic clones infecting cystic fibrosis patients in Italy. J Clin Microbiol. 2005;43:5136-42 pubmed
    To analyze national prevalence, genomovar distribution, and epidemiology of the Burkholderia cepacia complex in Italy, 225 putative B. cepacia complex isolates were obtained from 225 cystic fibrosis (CF) patients attending 18 CF centers...
  25. Horsley A, Jones A. Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation. Cochrane Database Syst Rev. 2012;10:CD009529 pubmed publisher
    ..Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 17 closely-related species of gram-negative bacteria, are particularly difficult ..
  26. Koh S, Tay S, Sermswan R, Wongratanacheewin S, Chua K, Puthucheary S. Development of a multiplex PCR assay for rapid identification of Burkholderia pseudomallei, Burkholderia thailandensis, Burkholderia mallei and Burkholderia cepacia complex. J Microbiol Methods. 2012;90:305-8 pubmed publisher
    ..of cultures for Burkholderia pseudomallei, Burkholderia thailandensis, Burkholderia mallei and Burkholderia cepacia complex. The assay is valuable for use in clinical and veterinary laboratories, and in a deployable laboratory ..
  27. Bartholdson S, Brown A, Mewburn B, Clarke D, Fry S, Campopiano D, et al. Plant host and sugar alcohol induced exopolysaccharide biosynthesis in the Burkholderia cepacia complex. Microbiology. 2008;154:2513-21 pubmed publisher
    The species that presently constitute the Burkholderia cepacia complex (Bcc) have multiple roles; they include soil and water saprophytes, bioremediators, and plant, animal and human pathogens...
  28. Campana S, Taccetti G, Ravenni N, Masi I, Audino S, Sisi B, et al. Molecular epidemiology of Pseudomonas aeruginosa, Burkholderia cepacia complex and methicillin-resistant Staphylococcus aureus in a cystic fibrosis center. J Cyst Fibros. 2004;3:159-63 pubmed
    Chronic pulmonary infections caused by Pseudomonas aeruginosa, Burkholderia cepacia complex and Staphylococcus aureus are responsible for most of the morbidity and mortality of patients with cystic fibrosis (CF)...
  29. Baldwin A, Mahenthiralingam E, Drevinek P, Vandamme P, Govan J, Waine D, et al. Environmental Burkholderia cepacia complex isolates in human infections. Emerg Infect Dis. 2007;13:458-61 pubmed
    Members of the Burkholderia cepacia complex (Bcc), found in many environments, are associated with clinical infections...
  30. Hunt T, Kooi C, Sokol P, Valvano M. Identification of Burkholderia cenocepacia genes required for bacterial survival in vivo. Infect Immun. 2004;72:4010-22 pubmed
    Burkholderia cenocepacia (formerly Burkholderia cepacia complex genomovar III) causes chronic lung infections in patients with cystic fibrosis...
  31. Suppiger A, Schmid N, Aguilar C, Pessi G, Eberl L. Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex. Virulence. 2013;4:400-9 pubmed publisher
    The Burkholderia cepacia complex (Bcc) consists of 17 closely related species that are problematic opportunistic bacterial pathogens for cystic fibrosis patients and immunocompromised individuals...
  32. Holden M, Seth Smith H, Crossman L, Sebaihia M, Bentley S, Cerdeño Tárraga A, et al. The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients. J Bacteriol. 2009;191:261-77 pubmed publisher
    ..The J2315 genome contains evidence that its unique and highly adapted genetic content has played a significant role in its success as an epidemic CF pathogen...
  33. Ryall B, Lee X, Zlosnik J, Hoshino S, Williams H. Bacteria of the Burkholderia cepacia complex are cyanogenic under biofilm and colonial growth conditions. BMC Microbiol. 2008;8:108 pubmed publisher
    The Burkholderia cepacia complex (Bcc) is a collection of nine genotypically distinct but phenotypically similar species...
  34. Tomlin K, Malott R, Ramage G, Storey D, Sokol P, Ceri H. Quorum-sensing mutations affect attachment and stability of Burkholderia cenocepacia biofilms. Appl Environ Microbiol. 2005;71:5208-18 pubmed
  35. Ramette A, LiPuma J, Tiedje J. Species abundance and diversity of Burkholderia cepacia complex in the environment. Appl Environ Microbiol. 2005;71:1193-201 pubmed publisher
    Despite considerable interest in studying Burkholderia cepacia complex in the environment, we still do not have efficient methods to detect, isolate, and screen large numbers of B. cepacia isolates...
  36. Bamford S, Ryley H, Jackson S. Highly purified lipopolysaccharides from Burkholderia cepacia complex clinical isolates induce inflammatory cytokine responses via TLR4-mediated MAPK signalling pathways and activation of NFkappaB. Cell Microbiol. 2007;9:532-43 pubmed
    In cystic fibrosis (CF), bacteria of the Burkholderia cepacia complex (Bcc) can induce a fulminant inflammation with pneumonitis and sepsis...
  37. Malott R, Baldwin A, Mahenthiralingam E, Sokol P. Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia. Infect Immun. 2005;73:4982-92 pubmed
    ..The cciR mutant had less protease activity than the parent strain. The phenotypes of the cepI cciI and cepR cciR mutants were similar to cepI or cepR mutants, with less protease activity and swarming motility than the parent strain...
  38. Markey K, Glendinning K, Morgan J, Hart C, Winstanley C. Caenorhabditis elegans killing assay as an infection model to study the role of type III secretion in Burkholderia cenocepacia. J Med Microbiol. 2006;55:967-9 pubmed
  39. Duff C, Murphy P, Callaghan M, McClean S. Differences in invasion and translocation of Burkholderia cepacia complex species in polarised lung epithelial cells in vitro. Microb Pathog. 2006;41:183-92 pubmed
    In order to investigate the mechanisms by which Burkholderia cepacia complex (Bcc) strains cross the epithelial barrier of the lung and cause septicaemia in a subgroup of Cystic Fibrosis (CF) patients, the invasiveness of four Bcc species ..
  40. Ferri L, Perrin E, Campana S, Tabacchioni S, Taccetti G, Cocchi P, et al. Application of multiplex single nucleotide primer extension (mSNuPE) to the identification of bacteria: the Burkholderia cepacia complex case. J Microbiol Methods. 2010;80:251-6 pubmed publisher
    b>Burkholderia cepacia complex (BCC) is characterized by a complex taxonomy constituted by seventeen closely related species of both biotechnological and clinical importance...
  41. Lamothe J, Huynh K, Grinstein S, Valvano M. Intracellular survival of Burkholderia cenocepacia in macrophages is associated with a delay in the maturation of bacteria-containing vacuoles. Cell Microbiol. 2007;9:40-53 pubmed
    Strains of the Burkholderia cepacia complex (Bcc) are opportunistic bacteria that can cause life-threatening infections in patients with cystic fibrosis and chronic granulomatous disease...
  42. De Soyza A, Silipo A, Lanzetta R, Govan J, Molinaro A. Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides. Innate Immun. 2008;14:127-44 pubmed publisher
    The Burkholderia cepacia complex comprises 10 closely related Gram-negative organisms all of which appear capable of causing disease in humans. These organisms appear of particular relevance to patients with cystic fibrosis...
  43. Ferreira A, Leitão J, Silva I, Pinheiro P, Sousa S, Ramos C, et al. Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions. Appl Environ Microbiol. 2010;76:441-50 pubmed publisher
    ..Genome sequence analyses of representative Burkholderia cepacia complex (Bcc) and non-Bcc strains for the presence of the bce-I gene cluster, directing the biosynthesis of the ..
  44. AuCoin D, Crump R, Thorkildson P, Nuti D, LiPuma J, Kozel T. Identification of Burkholderia cepacia complex bacteria with a lipopolysaccharide-specific monoclonal antibody. J Med Microbiol. 2010;59:41-7 pubmed publisher
    ..b>Burkholderia cepacia complex (Bcc) bacteria (which include at least 17 separate species) produce LPS structures that are quite ..
  45. Thomson E, Dennis J. A Burkholderia cepacia complex non-ribosomal peptide-synthesized toxin is hemolytic and required for full virulence. Virulence. 2012;3:286-98 pubmed publisher
    Members of the Burkholderia cepacia complex (Bcc) have recently gained notoriety as significant bacterial pathogens due to their extreme levels of antibiotic resistance, their transmissibility in clinics, their persistence in ..
  46. Rose H, Baldwin A, Dowson C, Mahenthiralingam E. Biocide susceptibility of the Burkholderia cepacia complex. J Antimicrob Chemother. 2009;63:502-10 pubmed publisher
    The Burkholderia cepacia complex (Bcc) species are important opportunistic pathogens with intrinsic antibiotic resistance...
  47. Yara R, Maccheroni W, Horii J, Azevedo J. A bacterium belonging to the Burkholderia cepacia complex associated with Pleurotus ostreatus. J Microbiol. 2006;44:263-8 pubmed
    ..was identified via the analysis of a partial 16S rDNA sequence; it was determined to belong to the Burkholderia cepacia complex, but was not closely related to other fungus-isolated Burkholderiaceae...
  48. Martins I, Pellegrino F, Freitas A, Santos M, Ferraiuoli G, Vasques M, et al. Case-crossover study of Burkholderia cepacia complex bloodstream infection associated with contaminated intravenous bromopride. Infect Control Hosp Epidemiol. 2010;31:516-21 pubmed publisher
    To investigate an outbreak of healthcare-associated Burkholderia cepacia complex (BCC) primary bloodstream infections (BCC-BSI).
  49. Kenna D, Yesilkaya H, Forbes K, Barcus V, Vandamme P, Govan J. Distribution and genomic location of active insertion sequences in the Burkholderia cepacia complex. J Med Microbiol. 2006;55:1-10 pubmed
    This study aimed firstly to establish the distribution and copy number within the Burkholderia cepacia complex of three insertion sequences (IS402, IS407 and IS1416) that possess the ability to activate transcription and hence influence ..
  50. Thomas M. Iron acquisition mechanisms of the Burkholderia cepacia complex. Biometals. 2007;20:431-52 pubmed
    The Burkholderia cepacia complex (Bcc) is comprised of at least 10 closely related species of Gram-negative proteobacteria that are associated with infections in certain groups of immunocompromised individuals, particularly those with ..
  51. Vanlaere E, Sergeant K, Dawyndt P, Kallow W, Erhard M, Sutton H, et al. Matrix-assisted laser desorption ionisation-time-of of-flight mass spectrometry of intact cells allows rapid identification of Burkholderia cepacia complex. J Microbiol Methods. 2008;75:279-86 pubmed publisher
    ..desorption ionisation-time-of-flight mass spectrometry (MALDI-TOF MS) for a rapid identification of Burkholderia cepacia complex (Bcc) bacteria using an Applied Biosystems 4700 Proteomics Analyser...
  52. Vanlaere E, LiPuma J, Baldwin A, Henry D, De Brandt E, Mahenthiralingam E, et al. Burkholderia latens sp. nov., Burkholderia diffusa sp. nov., Burkholderia arboris sp. nov., Burkholderia seminalis sp. nov. and Burkholderia metallica sp. nov., novel species within the Burkholderia cepacia complex. Int J Syst Evol Microbiol. 2008;58:1580-90 pubmed publisher
    The taxonomic position of five recA gene clusters of Burkholderia cepacia complex (Bcc) isolates was determined using a polyphasic taxonomic approach...
  53. Martin M, Christiansen B, Caspari G, Hogardt M, von Thomsen A, Ott E, et al. Hospital-wide outbreak of Burkholderia contaminans caused by prefabricated moist washcloths. J Hosp Infect. 2011;77:267-70 pubmed publisher
    ..In case of infections due to contaminated products, immediate communication to healthcare authorities is required, including RAPEX warning if products are sold across Europe...
  54. Summer E, Gonzalez C, Bomer M, Carlile T, Embry A, Kucherka A, et al. Divergence and mosaicism among virulent soil phages of the Burkholderia cepacia complex. J Bacteriol. 2006;188:255-68 pubmed
    ..of four virulent myophages, Bcep1, Bcep43, BcepB1A, and Bcep781, whose hosts are soil isolates of the Burkholderia cepacia complex. Despite temporal and spatial separations between initial isolations, three of the phages (Bcep1, ..
  55. Jacobs J, Fasi A, Ramette A, Smith J, Hammerschmidt R, Sundin G. Identification and onion pathogenicity of Burkholderia cepacia complex isolates from the onion rhizosphere and onion field soil. Appl Environ Microbiol. 2008;74:3121-9 pubmed publisher
    b>Burkholderia cepacia complex strains are genetically related but phenotypically diverse organisms that are important opportunistic pathogens in patients with cystic fibrosis (CF,) as well as pathogens of onion and banana, colonizers of ..
  56. Messiaen A, Verbrugghen T, Declerck C, Ortmann R, Schlitzer M, Nelis H, et al. Resistance of the Burkholderia cepacia complex to fosmidomycin and fosmidomycin derivatives. Int J Antimicrob Agents. 2011;38:261-4 pubmed publisher
    The Burkholderia cepacia complex (BCC) is a group of 17 closely related opportunistic pathogens that are able to infect the respiratory tract of cystic fibrosis patients...
  57. Loutet S, Valvano M. A decade of Burkholderia cenocepacia virulence determinant research. Infect Immun. 2010;78:4088-100 pubmed publisher
    The Burkholderia cepacia complex (Bcc) is a group of genetically related environmental bacteria that can cause chronic opportunistic infections in patients with cystic fibrosis (CF) and other underlying diseases...
  58. McKeon S, Nguyen D, Viteri D, Zlosnik J, Sokol P. Functional quorum sensing systems are maintained during chronic Burkholderia cepacia complex infections in patients with cystic fibrosis. J Infect Dis. 2011;203:383-92 pubmed publisher
    Quorum sensing (QS) contributes to the virulence of Pseudomonas aeruginosa and Burkholderia cepacia complex lung infections. P. aeruginosa QS mutants are frequently isolated from patients with cystic fibrosis...
  59. Herasimenka Y, Cescutti P, Impallomeni G, Campana S, Taccetti G, Ravenni N, et al. Exopolysaccharides produced by clinical strains belonging to the Burkholderia cepacia complex. J Cyst Fibros. 2007;6:145-52 pubmed
    ..clarify the role of exopolysaccharides (EPS) in bacterial virulence, EPS produced by species of the Burkholderia cepacia complex (Bcc), namely Burkholderia multivorans, Burkholderia cenocepacia, and a Bcc member of undetermined ..
  60. Moreira B, Leobons M, Pellegrino F, Santos M, Teixeira L, de Andrade Marques E, et al. Ralstonia pickettii and Burkholderia cepacia complex bloodstream infections related to infusion of contaminated water for injection. J Hosp Infect. 2005;60:51-5 pubmed
    Ralstonia pickettii and Burkholderia cepacia complex isolates are causes of healthcare-associated infection related to contamination of intravenously administered products...
  61. Carmody L, Gill J, Summer E, Sajjan U, Gonzalez C, YOUNG R, et al. Efficacy of bacteriophage therapy in a model of Burkholderia cenocepacia pulmonary infection. J Infect Dis. 2010;201:264-71 pubmed publisher
    ..cenocepacia lung infection model. Systemic phage administration was more effective than inhalational administration, suggesting that circulating phages have better access to bacteria in lungs than do topical phages...
  62. Brown A, Govan J. Assessment of fluorescent in situ hybridization and PCR-based methods for rapid identification of Burkholderia cepacia complex organisms directly from sputum samples. J Clin Microbiol. 2007;45:1920-6 pubmed
    Several species within the Burkholderia cepacia complex (BCC) have emerged as significant opportunistic pathogens of patients with cystic fibrosis (CF)...
  63. Mullen T, Markey K, Murphy P, McClean S, Callaghan M. Role of lipase in Burkholderia cepacia complex (Bcc) invasion of lung epithelial cells. Eur J Clin Microbiol Infect Dis. 2007;26:869-77 pubmed
    The Burkholderia cepacia complex (Bcc) is a group of ten closely related species associated with life-threatening infection in cystic fibrosis (CF)...
  64. Glendinning K, Parsons Y, Duangsonk K, Hales B, Humphreys D, Hart C, et al. Sequence divergence in type III secretion gene clusters of the Burkholderia cepacia complex. FEMS Microbiol Lett. 2004;235:229-35 pubmed
    The Burkholderia cepacia complex (BCC) comprises a group of bacteria associated with opportunistic infections, especially in cystic fibrosis patients. B...
  65. Pope C, Gillespie S, Moore J, McHugh T. Approaches to measure the fitness of Burkholderia cepacia complex isolates. J Med Microbiol. 2010;59:679-86 pubmed publisher
    Members of the Burkholderia cepacia complex (Bcc) are highly resistant to many antibacterial agents and infection can be difficult to eradicate...
  66. Waine D, Henry D, Baldwin A, Speert D, Honeybourne D, Mahenthiralingam E, et al. Reliability of multilocus sequence typing of the Burkholderia cepacia complex in cystic fibrosis. J Cyst Fibros. 2007;6:215-9 pubmed
    Infection with the Burkholderia cepacia complex is an important cause of morbidity and mortality in cystic fibrosis (CF)...
  67. Chung J, Speert D. Proteomic identification and characterization of bacterial factors associated with Burkholderia cenocepacia survival in a murine host. Microbiology. 2007;153:206-14 pubmed
    Burkholderia cenocepacia is a member of the Burkholderia cepacia complex, a diverse family of Gram-negative bacteria that are serious respiratory pathogens in immunocompromised patients and individuals with cystic fibrosis...
  68. Vial L, Chapalain A, Groleau M, Déziel E. The various lifestyles of the Burkholderia cepacia complex species: a tribute to adaptation. Environ Microbiol. 2011;13:1-12 pubmed publisher
    The Burkholderia cepacia complex (Bcc) is composed of 17 closely related species. These bacteria are widely but heterogeneously distributed in the natural environment, such as soil, water and rhizosphere...
  69. Golshahi L, Seed K, Dennis J, Finlay W. Toward modern inhalational bacteriophage therapy: nebulization of bacteriophages of Burkholderia cepacia complex. J Aerosol Med Pulm Drug Deliv. 2008;21:351-60 pubmed publisher
    ..purpose of the present in vitro study was to investigate the possibility of respiratory delivery of a Burkholderia cepacia complex (BCC) bacteriophage by nebulized aerosol administration...
  70. Ku N, Han S, Kim C, Baek J, Jeong S, Jin S, et al. Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia. Scand J Infect Dis. 2011;43:792-7 pubmed publisher
    Over the last 2 decades, Burkholderia cepacia complex has emerged as a serious human pathogen, especially in critically ill patients. B...
  71. Vinion Dubiel A, Goldberg J. Lipopolysaccharide of Burkholderia cepacia complex. J Endotoxin Res. 2003;9:201-13 pubmed
    b>Burkholderia cepacia complex (Bcc) is a group of phenotypically similar, genetically distinct bacteria that are beneficial to the environment but can also cause severe human infections...
  72. Boussaud V, Guillemain R, Grenet D, Coley N, Souilamas R, Bonnette P, et al. Clinical outcome following lung transplantation in patients with cystic fibrosis colonised with Burkholderia cepacia complex: results from two French centres. Thorax. 2008;63:732-7 pubmed publisher
    Infection with Burkholderia cepacia complex (BCC) is a life threatening complication of cystic fibrosis (CF), often seen as a contraindication for lung transplantation.
  73. Lynch K, Dennis J. Development of a species-specific fur gene-based method for identification of the Burkholderia cepacia complex. J Clin Microbiol. 2008;46:447-55 pubmed
    ..ecological and pathogenic importance, including nine closely related species collectively termed the Burkholderia cepacia complex (BCC)...
  74. Mahenthiralingam E, Urban T, Goldberg J. The multifarious, multireplicon Burkholderia cepacia complex. Nat Rev Microbiol. 2005;3:144-56 pubmed
    The Burkholderia cepacia complex (Bcc) is a collection of genetically distinct but phenotypically similar bacteria that are divided into at least nine species...
  75. Ibrahim M, Tang Q, Shi Y, Almoneafy A, Fang Y, Xu L, et al. Diversity of potential pathogenicity and biofilm formation among Burkholderia cepacia complex water, clinical, and agricultural isolates in China. World J Microbiol Biotechnol. 2012;28:2113-23 pubmed publisher
    A collection of 70 Burkholderia cepacia complex isolates, recovered from clinical, water, and agricultural resources in China in our previous studies, were tested to assess their potential pathogenicity and association of biofilm ..
  76. Papaleo M, Fondi M, Maida I, Perrin E, Lo Giudice A, Michaud L, et al. Sponge-associated microbial Antarctic communities exhibiting antimicrobial activity against Burkholderia cepacia complex bacteria. Biotechnol Adv. 2012;30:272-93 pubmed publisher
    ..produce antimicrobial compounds active toward Cystic Fibrosis opportunistic pathogens belonging to the Burkholderia cepacia complex (Bcc)...
  77. Lou M, Fang Y, Zhang G, Xie G, Zhu B, Ibrahim M. Diversity of Burkholderia cepacia complex from the Moso bamboo (Phyllostachys edulis) rhizhosphere soil. Curr Microbiol. 2011;62:650-8 pubmed publisher
    The purpose of this study was to determine the existence of Burkholderia cepacia complex (Bcc) at species level and the predominant species in the environment of moso bamboo plantations in Hangzhou, China...
  78. Van Acker H, Van Snick E, Nelis H, Coenye T. In vitro activity of temocillin against planktonic and sessile Burkholderia cepacia complex bacteria. J Cyst Fibros. 2010;9:450-4 pubmed publisher
    b>Burkholderia cepacia complex (Bcc) bacteria are opportunistic respiratory pathogens which are particularly difficult to eradicate from the lungs of cystic fibrosis (CF) patients because of their innate resistance to antimicrobials and ..
  79. Sousa S, Ramos C, Moreira L, Leitão J. The hfq gene is required for stress resistance and full virulence of Burkholderia cepacia to the nematode Caenorhabditis elegans. Microbiology. 2010;156:896-908 pubmed publisher
    The Burkholderia cepacia complex (Bcc) emerged as problematic opportunistic pathogens to cystic fibrosis (CF) patients...
  80. Zhou J, Chen Y, Tabibi S, Alba L, Garber E, Saiman L. Antimicrobial susceptibility and synergy studies of Burkholderia cepacia complex isolated from patients with cystic fibrosis. Antimicrob Agents Chemother. 2007;51:1085-8 pubmed
    ..tobramycin) and checkerboard synergy (23 combinations) studies were performed for 2,621 strains of Burkholderia cepacia complex isolated from 1,257 cystic fibrosis patients...
  81. Gautam V, Singhal L, Ray P. Burkholderia cepacia complex: beyond pseudomonas and acinetobacter. Indian J Med Microbiol. 2011;29:4-12 pubmed publisher
    b>Burkholderia cepacia complex (BCC) is an important nosocomial pathogen in hospitalised patients, particularly those with prior broad-spectrum antibacterial therapy...
  82. Cesarini S, Bevivino A, Tabacchioni S, Chiarini L, Dalmastri C. RecA gene sequence and Multilocus Sequence Typing for species-level resolution of Burkholderia cepacia complex isolates. Lett Appl Microbiol. 2009;49:580-8 pubmed publisher
    To identify, by means of recA sequencing and multilocus sequence typing (MLST), Burkholderia cepacia complex (BCC) isolates of environmental and clinical origin, which failed to be identified by recA RFLP and species-specific PCR.
  83. Tegos G, Haynes M, Schweizer H. Dissecting novel virulent determinants in the Burkholderia cepacia complex. Virulence. 2012;3:234-7 pubmed publisher
    ..Despite beneficial aspects such as use in biocontrol and bioremediation exhibited by members of the Burkholderia cepacia complex (Bcc) some members of this group have recently gained attention as significant bacterial pathogens due ..
  84. Shu Z, Lin R, Jiang H, Zhang Y, Wang M, Huang J. A rapid and efficient method for directed screening of lipase-producing Burkholderia cepacia complex strains with organic solvent tolerance from rhizosphere. J Biosci Bioeng. 2009;107:658-61 pubmed publisher
    ..All of the 14 lipolytic bacteria were identified as B. cepacia complex strains except that the recA gene sequence of one lipolytic bacterium, strain ZMB009, was not obtained...
  85. Caraher E, Reynolds G, Murphy P, McClean S, Callaghan M. Comparison of antibiotic susceptibility of Burkholderia cepacia complex organisms when grown planktonically or as biofilm in vitro. Eur J Clin Microbiol Infect Dis. 2007;26:213-6 pubmed
    This study determined the antibiotic susceptibility of planktonic and biofilm cultures of Burkholderia cepacia complex organisms, a group of highly problematic pathogens associated with cystic fibrosis patients...
  86. Jordá Vargas L, Degrossi J, Castañeda N, D Aquino M, Valvano M, Procopio A, et al. Prevalence of indeterminate genetic species of Burkholderia cepacia complex in a cystic fibrosis center in Argentina. J Clin Microbiol. 2008;46:1151-2 pubmed publisher
  87. Vermis K, Brachkova M, Vandamme P, Nelis H. Isolation of Burkholderia cepacia complex genomovars from waters. Syst Appl Microbiol. 2003;26:595-600 pubmed
    The aim of this study was to develop a selective enrichment broth as an aid for the isolation of Burkholderia cepacia complex (Bcc) bacteria from water...