brucella suis

Summary

Summary: A species of gram-negative bacteria, primarily infecting SWINE, but it can also infect humans, DOGS, and HARES.

Top Publications

  1. Billard E, Dornand J, Gross A. Interaction of Brucella suis and Brucella abortus rough strains with human dendritic cells. Infect Immun. 2007;75:5916-23 pubmed
    ..In the present paper, we report that, in contrast to smooth bacteria, infection of DCs with rough mutants of Brucella suis or Brucella abortus leads to both phenotypic and functional maturation of infected cells...
  2. Wu N, Abril C, Hinić V, Brodard I, Thur B, Fattebert J, et al. Free-ranging wild boar: a disease threat to domestic pigs in Switzerland?. J Wildl Dis. 2011;47:868-79 pubmed
    ..There may be a risk of B. suis spillover from wild boars in Switzerland, which could increase in the future. Data on the occurrence of interactions between pigs and wild boars are needed to assess this risk. ..
  3. Galindo R, Muñoz P, de Miguel M, Marin C, Labairu J, Revilla M, et al. Gene expression changes in spleens of the wildlife reservoir species, Eurasian wild boar (Sus scrofa), naturally infected with Brucella suis biovar 2. J Genet Genomics. 2010;37:725-36 pubmed publisher
    b>Brucella suis is responsible for swine brucellosis worldwide. Of the five different B. suis biovars (bv.), bv...
  4. Kohler S, Porte F, Jubier Maurin V, Ouahrani Bettache S, Teyssier J, Liautard J. The intramacrophagic environment of Brucella suis and bacterial response. Vet Microbiol. 2002;90:299-309 pubmed
    ..suis. Altogether, these results suggest three major stress conditions encountered by brucellae in the phagosome: acid stress, starvation and low oxygen tension...
  5. Posadas D, Martin F, Sabio y García J, Spera J, Delpino M, Baldi P, et al. The TolC homologue of Brucella suis is involved in resistance to antimicrobial compounds and virulence. Infect Immun. 2007;75:379-89 pubmed
    ..The gene encoding the unique member of the TolC family from Brucella suis (BepC) was cloned and expressed in an Escherichia coli mutant disrupted in the gene encoding TolC, which has ..
  6. Carle A, Höppner C, Ahmed Aly K, Yuan Q, den Dulk Ras A, Vergunst A, et al. The Brucella suis type IV secretion system assembles in the cell envelope of the heterologous host Agrobacterium tumefaciens and increases IncQ plasmid pLS1 recipient competence. Infect Immun. 2006;74:108-17 pubmed
    ..To overcome these problems, we heterologously expressed the Brucella suis virB operon in the closely related alpha(2)-proteobacterium Agrobacterium tumefaciens and showed that the VirB ..
  7. Sivanesan D, Hancock M, Villamil Giraldo A, Baron C. Quantitative analysis of VirB8-VirB9-VirB10 interactions provides a dynamic model of type IV secretion system core complex assembly. Biochemistry. 2010;49:4483-93 pubmed publisher
    ..We propose a dynamic model for secretion system assembly in which VirB8 plays a role as an assembly factor that is not closely associated with the functional core complex comprising VirB9 and VirB10...
  8. Joseph P, Turtaut F, Ouahrani Bettache S, Montero J, Nishimori I, Minakuchi T, et al. Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis. J Med Chem. 2010;53:2277-85 pubmed publisher
    A beta-carbonic anhydrase (CA, EC 4.2.1.1) from the bacterial pathogen Brucella suis, bsCA 1, has been cloned, purified, and characterized kinetically...
  9. Boigegrain R, Salhi I, Alvarez Martinez M, Machold J, Fedon Y, Arpagaus M, et al. Release of periplasmic proteins of Brucella suis upon acidic shock involves the outer membrane protein Omp25. Infect Immun. 2004;72:5693-703 pubmed
    ..In order to identify proteins released by Brucella during this early acidification step, we analyzed Brucella suis conditioned medium at various pH levels. No significant proteins were released at pH 4...

More Information

Publications65

  1. Salcedo S, Chevrier N, Lacerda T, Ben Amara A, Gerart S, Gorvel V, et al. Pathogenic brucellae replicate in human trophoblasts. J Infect Dis. 2013;207:1075-83 pubmed publisher
    ..Because EVTs are essential for implantation during early stages of pregnancy, the nature of the replication niche may have a central role during Brucella-associated abortion in infected women...
  2. Chen F, Ding X, Ding Y, Xiang Z, Li X, Ghosh D, et al. Proinflammatory caspase-2-mediated macrophage cell death induced by a rough attenuated Brucella suis strain. Infect Immun. 2011;79:2460-9 pubmed publisher
    ..This unique cell death differs from apoptosis, which is not proinflammatory. It is also different from classical pyroptosis, which is caspase-1 mediated...
  3. Porte F, Naroeni A, Ouahrani Bettache S, Liautard J. Role of the Brucella suis lipopolysaccharide O antigen in phagosomal genesis and in inhibition of phagosome-lysosome fusion in murine macrophages. Infect Immun. 2003;71:1481-90 pubmed
    ..In this study, we show that the LPS O side chain is involved in inhibition of the early fusion between Brucella suis-containing phagosomes and lysosomes in murine macrophages...
  4. Cvetnic Z, Mitak M, Ocepek M, Lojkic M, Terzic S, Jemersic L, et al. Wild boars (Sus scrofa) as reservoirs of Brucella suis biovar 2 in Croatia. Acta Vet Hung. 2003;51:465-73 pubmed
    ..1%) swine, as well as from 10 (62.5%) out of 16 aborted piglets. In all the isolates Brucella suis biovar 2 was identified. Wild boars are carriers and reservoirs of Brucella suis biovar 2 in Croatia.
  5. Dornand J, Lafont V, Oliaro J, Terraza A, Castaneda Roldan E, Liautard J. Impairment of intramacrophagic Brucella suis multiplication by human natural killer cells through a contact-dependent mechanism. Infect Immun. 2004;72:2303-11 pubmed
    ..Therefore, we have analyzed the behavior of Brucella suis infecting isolated human macrophages in the presence of syngeneic NK cells...
  6. Billard E, Dornand J, Gross A. VirB type IV secretory system does not contribute to Brucella suis' avoidance of human dendritic cell maturation. FEMS Immunol Med Microbiol. 2008;53:404-12 pubmed publisher
  7. Billard E, Cazevieille C, Dornand J, Gross A. High susceptibility of human dendritic cells to invasion by the intracellular pathogens Brucella suis, B. abortus, and B. melitensis. Infect Immun. 2005;73:8418-24 pubmed
    ..Here we report that DCs display a great susceptibility to Brucella infection. Therefore, DCs might serve as a reservoir and be important for the development of Brucella bacteria within their host...
  8. Cvetnic Z, Spicic S, Curic S, Jukic B, Lojkic M, Albert D, et al. Isolation of Brucella suis biovar 3 from horses in Croatia. Vet Rec. 2005;156:584-5 pubmed
  9. López Goñi I, García Yoldi D, Marin C, de Miguel M, Barquero Calvo E, Guzmán Verri C, et al. New Bruce-ladder multiplex PCR assay for the biovar typing of Brucella suis and the discrimination of Brucella suis and Brucella canis. Vet Microbiol. 2011;154:152-5 pubmed publisher
    Rapid and specific identification of Brucella suis at the biovar level is necessary because some of the biovars that infect animals are pathogenic for humans...
  10. Loisel Meyer S, Jiménez de Bagüés M, Basseres E, Dornand J, Kohler S, Liautard J, et al. Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection. Infect Immun. 2006;74:1973-6 pubmed
    A mutant of Brucella suis bearing a Tn5 insertion in norD, the last gene of the operon norEFCBQD, encoding nitric oxide reductase, was unable to survive under anaerobic denitrifying conditions...
  11. Loisel Meyer S, Jiménez de Bagüés M, Kohler S, Liautard J, Jubier Maurin V. Differential use of the two high-oxygen-affinity terminal oxidases of Brucella suis for in vitro and intramacrophagic multiplication. Infect Immun. 2005;73:7768-71 pubmed
    Expression of the high-oxygen-affinity cytochrome cbb3 and cytochrome bd ubiquinol oxidases of Brucella suis was studied in vitro and in the intramacrophagic niche, which was previously proposed to be oxygen limited...
  12. Terradot L, Bayliss R, Oomen C, Leonard G, Baron C, Waksman G. Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori. Proc Natl Acad Sci U S A. 2005;102:4596-601 pubmed
    ..Here we present crystal structures of VirB8 of Brucella suis, the causative agent of brucellosis, and ComB10, a VirB10 homolog of Helicobacter pylori, the causative agent ..
  13. Bandara A, Sriranganathan N, Schurig G, Boyle S. Carboxyl-terminal protease regulates Brucella suis morphology in culture and persistence in macrophages and mice. J Bacteriol. 2005;187:5767-75 pubmed
    The putative carboxyl-terminal processing protease (CtpA) of Brucella suis 1330 is a member of a novel family of endoproteases involved in the maturation of proteins destined for the cell envelope. The B...
  14. Lavigne J, O Callaghan D, Blanc Potard A. Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment. Infect Immun. 2005;73:3160-3 pubmed
    A Brucella suis mgtC mutant is defective for growth within macrophages and in low-Mg(2+) medium...
  15. Bessoles S, Dudal S, Besra G, Sanchez F, Lafont V. Human CD4+ invariant NKT cells are involved in antibacterial immunity against Brucella suis through CD1d-dependent but CD4-independent mechanisms. Eur J Immunol. 2009;39:1025-35 pubmed publisher
    ..We have examined the role of CD4(+) iNKT cells on the intracellular Brucella suis growth. Our results indicate that CD4(+) iNKT cells impair the intramacrophagic growth of Brucella...
  16. Al Dahouk S, Loisel Meyer S, Scholz H, Tomaso H, Kersten M, Harder A, et al. Proteomic analysis of Brucella suis under oxygen deficiency reveals flexibility in adaptive expression of various pathways. Proteomics. 2009;9:3011-21 pubmed publisher
    ..of the environmental parameters characteristic of the patho-physiological conditions of natural infections by Brucella suis. We previously showed that various respiratory pathways may be used by B...
  17. Ferrão Beck L, Cardoso R, Muñoz P, de Miguel M, Albert D, Ferreira A, et al. Development of a multiplex PCR assay for polymorphism analysis of Brucella suis biovars causing brucellosis in swine. Vet Microbiol. 2006;115:269-77 pubmed
    Swine brucellosis is caused by the biovars 1, 2 and 3 of Brucella suis the identification of which up to now relies on microbiological tests lacking adequate specificity together with time consuming and expensive molecular procedures...
  18. Dozot M, Boigegrain R, Delrue R, Hallez R, Ouahrani Bettache S, Danese I, et al. The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB. Cell Microbiol. 2006;8:1791-802 pubmed
    ..The Rsh deletion mutants in Brucella suis and Brucella melitensis were characterized by altered morphology, and by reduced survival under starvation ..
  19. Höppner C, Carle A, Sivanesan D, Hoeppner S, Baron C. The putative lytic transglycosylase VirB1 from Brucella suis interacts with the type IV secretion system core components VirB8, VirB9 and VirB11. Microbiology. 2005;151:3469-82 pubmed
    ..This paper presents the biochemical analysis of interactions of purified Brucella suis VirB1 with core components of the type IV secretion system...
  20. Abril C, Thomann A, Brodard I, Wu N, Ryser Degiorgis M, Frey J, et al. A novel isolation method of Brucella species and molecular tracking of Brucella suis biovar 2 in domestic and wild animals. Vet Microbiol. 2011;150:405-10 pubmed publisher
    b>Brucella suis biovar 2 is the most common aetiological agent of porcine brucellosis in Europe. B...
  21. Bandara A, Contreras A, Contreras Rodriguez A, Martins A, Dobrean V, Poff Reichow S, et al. Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice. BMC Microbiol. 2007;7:57 pubmed
    ..The Brucella genomes contain two urease operons designated as ure1 and ure2. We investigated the role of the two Brucella suis urease operons on the infection, intracellular persistence, growth, and resistance to low-pH killing.
  22. Billard E, Dornand J, Gross A. Brucella suis prevents human dendritic cell maturation and antigen presentation through regulation of tumor necrosis factor alpha secretion. Infect Immun. 2007;75:4980-9 pubmed
    ..This model defines a specific evasion strategy of the bacteria by which they can escape the immune response to chronically infect their host...
  23. Abdo M, Joseph P, Mortier J, Turtaut F, Montero J, Masereel B, et al. Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors. Org Biomol Chem. 2011;9:3681-90 pubmed publisher
    In the facultative intracellular pathogen Brucella suis, histidinol dehydrogenase (HDH) activity, catalyzing the last step in histidine biosynthesis, is essential for intramacrophagic replication...
  24. Tae H, Shallom S, Settlage R, Preston D, Adams L, Garner H. Revised genome sequence of Brucella suis 1330. J Bacteriol. 2011;193:6410 pubmed publisher
    b>Brucella suis is a causative agent of porcine brucellosis...
  25. Posadas D, Ruiz Ranwez V, Bonomi H, Martin F, Zorreguieta A. BmaC, a novel autotransporter of Brucella suis, is involved in bacterial adhesion to host cells. Cell Microbiol. 2012;14:965-82 pubmed publisher
    ..In an attempt to identify bacterial genes encoding adhesins, a phage display library of Brucella suis was panned against fibronectin. Three fibronectin-binding proteins of B...
  26. Maresca A, Scozzafava A, Kohler S, Winum J, Supuran C. Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions. J Inorg Biochem. 2012;110:36-9 pubmed publisher
    The bacterial pathogen Brucella suis encodes two carbonic anhydrases (CAs, EC 4.2.1.1) belonging to the ?-class, bsCA1 and bsCA2, which are crucial for its life cycle...
  27. Halling S, Peterson Burch B, Bricker B, Zuerner R, Qing Z, Li L, et al. Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis. J Bacteriol. 2005;187:2715-26 pubmed
    ..We report the complete genome sequence of Brucella abortus field isolate 9-941 and compare it to those of Brucella suis 1330 and Brucella melitensis 16 M...
  28. Kohler S, Foulongne V, Ouahrani Bettache S, Bourg G, Teyssier J, Ramuz M, et al. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proc Natl Acad Sci U S A. 2002;99:15711-6 pubmed
    The pathogen Brucella suis resides and multiplies within a phagocytic vacuole of its host cell, the macrophage...
  29. Yingst S, Huzella L, Chuvala L, Wolcott M. A rhesus macaque (Macaca mulatta) model of aerosol-exposure brucellosis (Brucella suis): pathology and diagnostic implications. J Med Microbiol. 2010;59:724-30 pubmed publisher
    ..g. bone marrow biopsy. We studied the pathogenesis of Brucella suis aerosol infection in rhesus macaques in an effort to guide the diagnostic algorithm in case of possible ..
  30. Wu N, Abril C, Thomann A, Grosclaude E, Doherr M, Boujon P, et al. Risk factors for contacts between wild boar and outdoor pigs in Switzerland and investigations on potential Brucella suis spill-over. BMC Vet Res. 2012;8:116 pubmed publisher
    ..Furthermore, exposed pigs were tested for pathogen spill-over, taking Brucella suis as an example because B...
  31. Koylass M, King A, Edwards Smallbone J, Gopaul K, Perrett L, Whatmore A. Comparative performance of SNP typing and 'Bruce-ladder' in the discrimination of Brucella suis and Brucella canis. Vet Microbiol. 2010;142:450-4 pubmed publisher
    ..Differentiation of Brucella canis from Brucella suis by molecular approaches can be difficult and here we compare the performance of 'Bruce-ladder' and SNP typing ..
  32. Smither S, Perkins S, Davies C, Stagg A, Nelson M, Atkins H. Development and characterization of mouse models of infection with aerosolized Brucella melitensis and Brucella suis. Clin Vaccine Immunol. 2009;16:779-83 pubmed publisher
    ..We have developed mouse models of infection with aerosolized Brucella melitensis and Brucella suis and demonstrated their utility for the evaluation of vaccines using the model live B...
  33. Bergagna S, Zoppi S, Ferroglio E, Gobetto M, Dondo A, Di Giannatale E, et al. Epidemiologic survey for Brucella suis biovar 2 in a wild boar (Sus scrofa) population in northwest Italy. J Wildl Dis. 2009;45:1178-81 pubmed
    ..9, P<0.00005 OR: 1, 2.5, 4.9, 7.5; chi(2(trend))=43.1, P<0.00002, OR: 1, 2.5, 2.9, 4.8, respectively)...
  34. Contreras Rodriguez A, Quiroz Limon J, Martins A, Peralta H, Avila Calderon E, Sriranganathan N, et al. Enzymatic, immunological and phylogenetic characterization of Brucella suis urease. BMC Microbiol. 2008;8:121 pubmed publisher
    ..The present work describes the purification and the enzymatic and phylogenomic characterization of urease from Brucella suis strain 1330. Additionally, the urease reactivity of sera from patients diagnosed with brucellosis was examined.
  35. García Yoldi D, Le Fleche P, de Miguel M, Muñoz P, Blasco J, Cvetnic Z, et al. Comparison of multiple-locus variable-number tandem-repeat analysis with other PCR-based methods for typing Brucella suis isolates. J Clin Microbiol. 2007;45:4070-2 pubmed
    ..MLVA), multiplex PCR, and PCR-restriction fragment length polymorphism analysis were compared for typing Brucella suis isolates. A perfect concordance was obtained among these molecular assays...
  36. Jiménez de Bagüés M, Loisel Meyer S, Liautard J, Jubier Maurin V. Different roles of the two high-oxygen-affinity terminal oxidases of Brucella suis: Cytochrome c oxidase, but not ubiquinol oxidase, is required for persistence in mice. Infect Immun. 2007;75:531-5 pubmed
    The survival of Brucella suis mutant strains in mice demonstrated different roles of the two high-oxygen-affinity terminal oxidases. The cbb3-type cytochrome c oxidase was essential for chronic infection in oxygen-deficient organs...
  37. Jiang H, Wang H, Xu L, Hu G, Ma J, Xiao P, et al. MLVA genotyping of Brucella melitensis and Brucella abortus isolates from different animal species and humans and identification of Brucella suis vaccine strain S2 from cattle in China. PLoS ONE. 2013;8:e76332 pubmed publisher
    ..MLVA typing could be an essential assay to improve brucellosis surveillance and control programs. ..
  38. Rajasekaran P, Alexander J, Seleem M, Jain N, Sriranganathan N, Wattam A, et al. Peptide nucleic acids inhibit growth of Brucella suis in pure culture and in infected murine macrophages. Int J Antimicrob Agents. 2013;41:358-62 pubmed publisher
    ..The susceptibility of a virulent Brucella suis strain to a variety of PNAs was assessed in pure culture as well as in murine macrophages...
  39. Meirelles Bartoli R, Mathias L, Samartino L. Brucellosis due to Brucella suis in a swine herd associated with a human clinical case in the State of São Paulo, Brazil. Trop Anim Health Prod. 2012;44:1575-9 pubmed publisher
    b>Brucella suis has been recognized as the major etiological agent of human brucellosis in areas free from Brucella melitensis infection...
  40. Burkhardt S, Jiménez de Bagüés M, Liautard J, Kohler S. Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages. Infect Immun. 2005;73:6782-90 pubmed
    ..Allelic exchange mutants in eryC of Brucella suis were erythritol sensitive in vitro with a MIC of 1 to 5 mM of erythritol...
  41. Paschos A, Patey G, Sivanesan D, Gao C, Bayliss R, Waksman G, et al. Dimerization and interactions of Brucella suis VirB8 with VirB4 and VirB10 are required for its biological activity. Proc Natl Acad Sci U S A. 2006;103:7252-7 pubmed
    ..the results of a structure-function analysis of the periplasmic domain of VirB8 from the mammalian pathogen Brucella suis, which identifies amino acid residues required for three protein-protein interactions...
  42. Dudal S, Turriere C, Bessoles S, Fontes P, Sanchez F, Liautard J, et al. Release of LL-37 by activated human Vgamma9Vdelta2 T cells: a microbicidal weapon against Brucella suis. J Immunol. 2006;177:5533-9 pubmed
    ..We also show that LL-37 has an antibacterial effect on Brucella suis. Overall, our results demonstrate that LL-37 is a soluble factor responsible for a part of the bactericidal ..
  43. Andrieux L, Bourg G, Pirone A, O Callaghan D, Patey G. A single amino acid change in the transmembrane domain of the VirB8 protein affects dimerization, interaction with VirB10 and Brucella suis virulence. FEBS Lett. 2011;585:2431-6 pubmed publisher
    VirB8 is a critical component of the Brucella suis type IV secretion system (T4SS)...
  44. Leuenberger R, Boujon P, Thur B, Miserez R, Garin Bastuji B, Rüfenacht J, et al. Prevalence of classical swine fever, Aujeszky's disease and brucellosis in a population of wild boar in Switzerland. Vet Rec. 2007;160:362-8 pubmed
    ..5 per cent for brucellosis. There was no serological evidence of classical swine fever or Aujeszky's disease, but brucellosis due to Brucella suis biovar 2 was confirmed serologically and by bacterial isolation.
  45. Joseph P, Ouahrani Bettache S, Montero J, Nishimori I, Minakuchi T, Vullo D, et al. A new ?-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth. Bioorg Med Chem. 2011;19:1172-8 pubmed publisher
    A ?-carbonic anhydrase (CA, EC 4.2.1.1) from the bacterial pathogen Brucella suis, bsCA II, has been cloned, purified, and characterized kinetically...
  46. Hare S, Bayliss R, Baron C, Waksman G. A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact. J Mol Biol. 2006;360:56-66 pubmed
    VirB11 ATPases are hexameric assemblies that power type IV secretion systems in bacteria. The hexamer of Brucella suis VirB11 (BsB11), like that of the Helicobacter pylori VirB11 (Hp0525), consists of a double ring structure formed by ..
  47. Joseph P, Abdo M, Boigegrain R, Montero J, Winum J, Kohler S. Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen. Antimicrob Agents Chemother. 2007;51:3752-5 pubmed
    b>Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues...
  48. Cvetnic Z, Spicic S, Toncic J, Majnaric D, Benic M, Albert D, et al. Brucella suis infection in domestic pigs and wild boar in Croatia. Rev Sci Tech. 2009;28:1057-67 pubmed
    ..5%) wild boar which were randomly submitted for bacteriological study. All but three isolates were Brucella suis biovar 2; the others being biovar 3...
  49. Boigegrain R, Liautard J, Kohler S. Targeting of the virulence factor acetohydroxyacid synthase by sulfonylureas results in inhibition of intramacrophagic multiplication of Brucella suis. Antimicrob Agents Chemother. 2005;49:3922-5 pubmed
    The acetohydroxyacid synthase (AHAS) of Brucella suis can be effectively targeted by the sulfonylureas chlorimuron ethyl and metsulfuron methyl...
  50. Lavigne J, Patey G, Sangari F, Bourg G, Ramuz M, O Callaghan D, et al. Identification of a new virulence factor, BvfA, in Brucella suis. Infect Immun. 2005;73:5524-9 pubmed
    ..factor A), a small periplasmic protein unique to the genus Brucella, which is essential for the virulence of Brucella suis. A BvfA knockout mutant was highly attenuated both in in vitro macrophage infection assays and in vivo in the ..
  51. Bandara A, Sriranganathan N, Schurig G, Boyle S. Putative outer membrane autotransporter protein influences survival of Brucella suis in BALB/c mice. Vet Microbiol. 2005;109:95-104 pubmed
    ..The influence of the putative outer membrane autotransporter (OmaA) protein to the persistence of Brucella suis was investigated. Sequence analyses revealed that the OmaA protein of B...
  52. Ruiz Ranwez V, Posadas D, Van der Henst C, Estein S, Arocena G, Abdian P, et al. BtaE, an adhesin that belongs to the trimeric autotransporter family, is required for full virulence and defines a specific adhesive pole of Brucella suis. Infect Immun. 2013;81:996-1007 pubmed publisher
    ..We have previously shown that the BmaC unipolar monomeric autotransporter mediates the binding of Brucella suis to host cells through cell-associated fibronectin. Our genome analysis shows that the B...
  53. Zaccheus M, Ali T, Cloeckaert A, Zygmunt M, Weintraub A, Iriarte M, et al. The epitopic and structural characterization of Brucella suis biovar 2 O-polysaccharide demonstrates the existence of a new M-negative C-negative smooth Brucella serovar. PLoS ONE. 2013;8:e53941 pubmed publisher
    ..Serologically and structurally this new serovar is more similar to Y. enterocolitica O:9 than to other brucellae...
  54. Al Dahouk S, Jubier Maurin V, Scholz H, Tomaso H, Karges W, Neubauer H, et al. Quantitative analysis of the intramacrophagic Brucella suis proteome reveals metabolic adaptation to late stage of cellular infection. Proteomics. 2008;8:3862-70 pubmed publisher
    A 2-D DIGE approach allowed the characterization of the intramacrophagic proteome of the intracellular pathogen Brucella suis at the late stage of in vitro infection by efficient discrimination between bacterial and host cell proteins...
  55. Abdou E, Deredjian A, Jiménez de Bagüés M, Kohler S, Jubier Maurin V. RegA, the regulator of the two-component system RegB/RegA of Brucella suis, is a controller of both oxidative respiration and denitrification required for chronic infection in mice. Infect Immun. 2013;81:2053-61 pubmed publisher
    ..The flexibility of this bacterium with respect to oxygen depletion is remarkable, since Brucella suis can use an oxygen-dependent transcriptional regulator of the FnrN family, two high-oxygen-affinity terminal ..
  56. Vullo D, Nishimori I, Scozzafava A, Kohler S, Winum J, Supuran C. Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides. Bioorg Med Chem Lett. 2010;20:2178-82 pubmed publisher
    A beta-carbonic anhydrase (CA, EC 4.2.1.1) from the bacterial pathogen Brucella suis, bsCA 1, has been cloned, purified characterized kinetically and for inhibition with a series of water soluble glycosylated sulfanilamides...