brucella canis

Summary

Summary: A species of gram-negative bacteria infecting DOGS, the natural hosts, and causing canine BRUCELLOSIS. It can also cause a mild infection in humans.

Top Publications

  1. Lucero N, Escobar G, Ayala S, Jacob N. Diagnosis of human brucellosis caused by Brucella canis. J Med Microbiol. 2005;54:457-61 pubmed
    The transmission of Brucella canis to man commonly occurs through contact with infected dogs or their secretions, or through direct laboratory exposure...
  2. Dahlbom M, Johnsson M, Myllys V, Taponen J, Andersson M. Seroprevalence of canine herpesvirus-1 and Brucella canis in Finnish breeding kennels with and without reproductive problems. Reprod Domest Anim. 2009;44:128-31 pubmed publisher
    We compared the serological status of Brucella canis and canine herpesvirus-1 (CHV-1) in Finnish breeding kennels with and without reproductive problems...
  3. Gyuranecz M, Szeredi L, Rónai Z, Denes B, Dencso L, Dan A, et al. Detection of Brucella canis-induced reproductive diseases in a kennel. J Vet Diagn Invest. 2011;23:143-7 pubmed
    ..and the strong immunostaining of trophoblast cells by immunohistochemistry (IHC) using hyperimmune rabbit anti-Brucella canis primary antibodies. The rapid slide agglutination test was positive in 7 of 31 (23%) cases. The organism B...
  4. Keid L, Soares R, Vasconcellos S, Megid J, Salgado V, Richtzenhain L. Comparison of agar gel immunodiffusion test, rapid slide agglutination test, microbiological culture and PCR for the diagnosis of canine brucellosis. Res Vet Sci. 2009;86:22-6 pubmed publisher
    ..According to the results observed the 167 dogs were divided into three groups: Brucella canis infected dogs (Group 1), B. canis non-infected dogs (Group 2) and dogs with suspected brucellosis (Group 3)...
  5. Ledbetter E, Landry M, Stokol T, Kern T, Messick J. Brucella canis endophthalmitis in 3 dogs: clinical features, diagnosis, and treatment. Vet Ophthalmol. 2009;12:183-91 pubmed publisher
    To describe historical, clinical and diagnostic features of dogs with Brucella canis endophthalmitis and the response to medical therapy.
  6. Kang S, Her M, Heo E, Nam H, Jung S, Cho D. Molecular typing for epidemiological evaluation of Brucella abortus and Brucella canis isolated in Korea. J Microbiol Methods. 2009;78:144-9 pubmed publisher
    ..Field strains of Brucella abortus and Brucella canis were isolated from 9 provinces in the Republic of Korea during the years 1996-2006 and each of the isolates ..
  7. Keid L, Soares R, Vasconcellos S, Chiebao D, Megid J, Salgado V, et al. A polymerase chain reaction for the detection of Brucella canis in semen of naturally infected dogs. Theriogenology. 2007;67:1203-10 pubmed
    The objective was to evaluate a PCR assay for the detection of Brucella canis in canine semen, comparing its performance with that of bacterial isolation, serological tests and PCR assay of blood...
  8. de Oliveira M, Vale V, Keid L, Freire S, Meyer R, Portela R, et al. Validation of an ELISA method for the serological diagnosis of canine brucellosis due to Brucella canis. Res Vet Sci. 2011;90:425-31 pubmed publisher
    ..antigenic extracts, obtained by heat or ultrasonic homogenization of microbial antigens from a wild isolate of Brucella canis bacteria, were compared by ELISA and Western blot (WB)...
  9. Corrente M, Franchini D, Decaro N, Greco G, D Abramo M, Greco M, et al. Detection of Brucella canis in a dog in Italy. New Microbiol. 2010;33:337-41 pubmed
    Brucella spp. is a worldwide zoonotic pathogen. Infection by Brucella canis in dogs is endemic in the Southern USA and in Central and South America, but it appears sporadically in other parts of the world, including Europe...

More Information

Publications78

  1. Hollett R. Canine brucellosis: outbreaks and compliance. Theriogenology. 2006;66:575-87 pubmed
    ..An important infectious agent is Brucella canis. Classically deemed a major reason of abortion, this organism also produces infertility in stud dogs and poses ..
  2. Lucero N, Jacob N, Ayala S, Escobar G, Tuccillo P, Jacques I. Unusual clinical presentation of brucellosis caused by Brucella canis. J Med Microbiol. 2005;54:505-8 pubmed
    b>Brucella canis is considered a rare cause of human brucellosis. The clinical importance of this infection may have been underestimated so far because of difficulties with presumptive diagnosis...
  3. López Goñi I, García Yoldi D, Marin C, de Miguel M, Barquero Calvo E, Guzmán Verri C, et al. New Bruce-ladder multiplex PCR assay for the biovar typing of Brucella suis and the discrimination of Brucella suis and Brucella canis. Vet Microbiol. 2011;154:152-5 pubmed publisher
    ..suis biovars in a single test and differentiation of B. suis from Brucella canis by molecular approaches can be difficult...
  4. Vinayak A, Greene C, Moore P, Powell Johnson G. Clinical resolution of Brucella canis-induced ocular inflammation in a dog. J Am Vet Med Assoc. 2004;224:1804-7, 1788-9 pubmed
    ..with an 8-month history of recurrent bilateral anterior uveitis and hyphema secondary to infection with Brucella canis. Treatment with doxycycline PO and atropine and prednisone acetate topically prior to referral had failed to ..
  5. Eskra L, Covert J, Glasner J, Splitter G. Differential expression of iron acquisition genes by Brucella melitensis and Brucella canis during macrophage infection. PLoS ONE. 2012;7:e31747 pubmed publisher
    ..Iron is a particularly scarce nutrient for bacteria with an intracellular lifestyle. Brucella melitensis and Brucella canis share ~99% of their genomes but differ in intracellular lifestyles...
  6. Tuemmers C, Lüders C, Rojas C, Serri M, Castillo C, Espinoza R. [Detection of Brucella canis by immunochromatography method in vague dogs captured in Temuco city, Chile, 2011]. Rev Chilena Infectol. 2013;30:395-401 pubmed publisher
    b>Brucella canis is responsible for brucellosis in dogs, causing reproductive disorders and is considered a zoonoses, as described in several countries. The epidemiological data are scarce in our country.
  7. Lawaczeck E, Toporek J, Cwikla J, Mathison B. Brucella canis in a HIV-infected patient. Zoonoses Public Health. 2011;58:150-2 pubmed publisher
    The true incidence of Brucella canis in humans is unknown, but immunocompromised patients in direct contact with dogs are thought to be at a higher risk for infection. In this case report, we present a human case of B...
  8. Ebani V, Cerri D, Fratini F, Bey R, Andreani E. Serological diagnosis of brucellosis caused by Brucella canis. New Microbiol. 2003;26:65-73 pubmed
    Blood serum samples from 2,328 dogs were tested to detect antibodies against Brucella canis with the agar gel immunodiffusion (AGID) and 2-mercaptoethanol slide agglutination test (ME-SAT) using Brucella ovis as the antigen...
  9. Kang S, Heo E, Cho D, Kim J, Kim J, Jung S, et al. Genetic comparison of Brucella canis isolates by the MLVA assay in South Korea. J Vet Med Sci. 2011;73:779-86 pubmed
    ..Therefore, the MLVA assay will be useful as a tool for control and preventive measures of canine brucellosis...
  10. Sayan M, Erdenlig S, Stack J, Kilic S, Güdücüoğlu H, Aksoy Y, et al. A serological diagnostic survey for Brucella canis infection in Turkish patients with Brucellosis-like symptoms. Jpn J Infect Dis. 2011;64:516-9 pubmed
    The incidence of Brucella canis infection in humans is unknown in Turkey. In this study, we investigated the prevalence of B...
  11. Keid L, Soares R, Vasconcellos S, Salgado V, Megid J, Richtzenhain L. Comparison of a PCR assay in whole blood and serum specimens for canine brucellosis diagnosis. Vet Rec. 2010;167:96-9 pubmed publisher
    ..serum PCR assay was compared with that of a blood PCR assay for the diagnosis of canine brucellosis caused by Brucella canis in 72 dogs...
  12. Lucero N, Maldonado P, Kaufman S, Escobar G, Boeri E, Jacob N. Brucella canis causing infection in an HIV-infected patient. Vector Borne Zoonotic Dis. 2010;10:527-9 pubmed publisher
    ..of an HIV-positive patient with a febrile syndrome (CD4 count 385 cells/microL and viral load nondetectable), Brucella canis was isolated...
  13. Holst B, Löfqvist K, Ernholm L, Eld K, Cedersmyg M, Hallgren G. The first case of Brucella canis in Sweden: background, case report and recommendations from a northern European perspective. Acta Vet Scand. 2012;54:18 pubmed publisher
    Infection with Brucella canis has been diagnosed in Sweden for the first time. It was diagnosed in a three-year-old breeding bitch with reproductive disturbances...
  14. Nockler K, Kutzer P, Reif S, Rosenberger N, Draeger A, Bahn P, et al. [Canine brucellosis--a case report]. Berl Munch Tierarztl Wochenschr. 2003;116:368-72 pubmed
    ..5 years. During the study SAT serum titre steadily dropped from 1:200 to 1:50. By CFT, B. canis antibodies were detectable at the beginning with a titre of 1:320 and to the end of the study with titres between 1:80 and 1:160...
  15. Wanke M, Delpino M, Baldi P. Use of enrofloxacin in the treatment of canine brucellosis in a dog kennel (clinical trial). Theriogenology. 2006;66:1573-8 pubmed
    ..The purpose of this study was to evaluate the efficacy of enrofloxacin in a kennel infected with Brucella canis. Twelve dogs, 2 males and 10 females (including 1 in estrus, 3 pregnant, and 6 in anestrus) infected with B...
  16. Kim S, Lee D, Suzuki H, Watarai M. Detection of Brucella canis and Leptospira interrogans in canine semen by multiplex nested PCR. J Vet Med Sci. 2006;68:615-8 pubmed
    b>Brucella canis and Leptospira interrogans are pathogenic bacteria that cause brucellosis and leptospirosis in dogs around the world...
  17. Keid L, Soares R, Vasconcellos S, Chiebao D, Salgado V, Megid J, et al. A polymerase chain reaction for detection of Brucella canis in vaginal swabs of naturally infected bitches. Theriogenology. 2007;68:1260-70 pubmed
    A PCR assay for the detection of Brucella canis in canine vaginal swab samples was evaluated, comparing its performance with that of bacterial isolation, serological tests, and a blood PCR assay...
  18. Aras Z, Uçan U. Detection of Brucella canis from inguinal lymph nodes of naturally infected dogs by PCR. Theriogenology. 2010;74:658-62 pubmed publisher
    The aim of this study was to standardize and evaluate a PCR assay for the detection of Brucella canis (B. canis) in lymph node samples of naturally infected dogs...
  19. Dunne J, Sehgal K, McMillan A, Perret L. Canine brucellosis in a dog imported into the UK. Vet Rec. 2002;151:247 pubmed
  20. Brower A, Okwumabua O, Massengill C, Muenks Q, Vanderloo P, Duster M, et al. Investigation of the spread of Brucella canis via the U.S. interstate dog trade. Int J Infect Dis. 2007;11:454-8 pubmed
    ..Our study objectives were to first characterize Brucella canis outbreaks in Wisconsin kennels in the context of the dog trade in the USA, and then to identify a molecular ..
  21. Martín Martín A, Vizcaino N, Fernández Lago L. Cholesterol, ganglioside GM1 and class A scavenger receptor contribute to infection by Brucella ovis and Brucella canis in murine macrophages. Microbes Infect. 2010;12:246-51 pubmed publisher
    The establishment of infection by Brucella ovis and Brucella canis in J774.A1 macrophages was found to be dependent upon cholesterol and ganglioside GM(1), two components of lipid rafts...
  22. Koylass M, King A, Edwards Smallbone J, Gopaul K, Perrett L, Whatmore A. Comparative performance of SNP typing and 'Bruce-ladder' in the discrimination of Brucella suis and Brucella canis. Vet Microbiol. 2010;142:450-4 pubmed publisher
    ..Differentiation of Brucella canis from Brucella suis by molecular approaches can be difficult and here we compare the performance of 'Bruce-..
  23. Lucero N, Corazza R, Almuzara M, Reynes E, Escobar G, Boeri E, et al. Human Brucella canis outbreak linked to infection in dogs. Epidemiol Infect. 2010;138:280-5 pubmed publisher
    The zoonotic risk of Brucella canis has been considered fairly high for persons who handle breeding dogs in kennels or are exposed to infected animals. Transmission to humans in other circumstances has been thought to be rare...
  24. Ferrero M, Fossati C, Baldi P. Smooth Brucella strains invade and replicate in human lung epithelial cells without inducing cell death. Microbes Infect. 2009;11:476-83 pubmed publisher
    ..The number of adherent and intracellular bacteria was higher for rough strains (Brucella canis and Brucella abortus RB51) than for smooth strains (B. abortus 2308 and Brucella suis 1330)...
  25. Viana M, Wattam A, Govil Batra D, Boisvert S, Brettin T, Frace M, et al. Genome Sequences of Three Brucella canis Strains Isolated from Humans and a Dog. Genome Announc. 2017;5: pubmed publisher
    i>Brucella canis is a facultative intracellular pathogen that preferentially infects members of the Canidae family...
  26. Gao G, Li J, Li T, Zhang Z, Wang L, Yuan X, et al. Complete genome sequence of Brucella canis strain 118, a strain isolated from canine. J Bacteriol. 2012;194:6680 pubmed publisher
    b>Brucella canis infects several species of animals, and canine is the preferred host. Genome sequences of strains from different hosts are valuable for comparative analysis of host adaptation and microevolution...
  27. Ruoff C, Kerwin S, Taylor A. Diagnostic Imaging of Discospondylitis. Vet Clin North Am Small Anim Pract. 2018;48:85-94 pubmed publisher
    ..Image-guided biopsy should be considered in addition to blood and urine cultures and Brucella canis screening and as an alternative to surgical biopsy in some cases.
  28. Lee S, Islam M, Khatun M, Choi G, Jung J, Baek B, et al. Immunoglobulin profiles in acute Brucellosis experimentally induced by Brucella canis in BALB/c mice. Vector Borne Zoonotic Dis. 2010;10:927-30 pubmed publisher
    ..profiles of immunoglobulin (Ig; IgA, IgG, IgG1, and IgG2a) response in experimental brucellosis induced with Brucella canis in BALB/c mice during an 8-week infection period...
  29. Pujol M, Castillo F, Alvarez C, Rojas C, Borie C, Ferreira A, et al. Variability in the response of canine and human dendritic cells stimulated with Brucella canis. Vet Res. 2017;48:72 pubmed publisher
    b>Brucella canis is a small intracellular Gram-negative bacterium whose primary host is the dog, but it also can cause mild human brucellosis...
  30. Tsogtbaatar G, Tachibana M, Watanabe K, Kim S, Suzuki H, Watarai M. Enzyme-linked immunosorbent assay for screening of canine brucellosis using recombinant Cu-Zn superoxide dismutase. J Vet Med Sci. 2008;70:1387-9 pubmed
    b>Brucella canis, a facultative intracellular pathogen, is the causative agent of canine brucellosis...
  31. Watarai M, Kim S, Yamamoto J, Miyahara K, Kazama M, Matsuoka S, et al. A rapid agglutination assay for canine brucellosis using antigen coated beads. J Vet Med Sci. 2007;69:477-80 pubmed
    b>Brucella canis is the causative agent of canine brucellosis and facultative intracellular pathogen...
  32. Keleher L, Skyberg J. Activation of bovine neutrophils by Brucella spp. Vet Immunol Immunopathol. 2016;177:1-6 pubmed publisher
    ..abortus, B. melitensis, B. suis, and virulent, rough, strains of Brucella canis possess similar abilities to resist killing by resting, or IFN-?-activated, bovine neutrophils...
  33. Kapil S. Canid herpesvirus 1 (CHV-1)-related disease in older puppies and CHV-1 shedding in the vagina of adult pregnant dogs. J Vet Diagn Invest. 2015;27:758-61 pubmed publisher
    ..CHV-1 is persistently circulating in this kennel in spite of high serum antibody titers in the adult dogs. The dogs were negative for canine brucellosis antibodies based on Brucella canis rapid card test.
  34. Cortina M, Novak A, Melli L, Elena S, Corbera N, Romero J, et al. Development of improved enzyme-based and lateral flow immunoassays for rapid and accurate serodiagnosis of canine brucellosis. Vet Microbiol. 2017;208:174-180 pubmed publisher
    Brucellosis is a widespread zoonotic disease caused by Brucella spp. Brucella canis is the etiological agent of canine brucellosis, a disease that can lead to sterility in bitches and dogs causing important economic losses in breeding ..
  35. Qian J, Bu Z, Lang X, Yan G, Yang Y, Wang X, et al. A safe and molecular-tagged Brucella canis ghosts confers protection against virulent challenge in mice. Vet Microbiol. 2017;204:121-128 pubmed publisher
    Canine brucellosis, caused by Brucella canis, is a persistent infectious reproductive disease in dogs...
  36. Purvis T, Krouse D, Miller D, Livengood J, Thirumalapura N, Tewari D. Detection of Brucella canis infection in dogs by blood culture and bacterial identification using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Vet Diagn Invest. 2017;29:586-588 pubmed publisher
    b>Brucella canis was recovered from dogs that were canine brucellosis suspect by blood culture using a modified lysis method...
  37. Palomares Resendiz E, Arellano Reynoso B, Hernandez Castro R, Tenorio Gutierrez V, Salas Téllez E, Suárez Güemes F, et al. Immunogenic response of Brucella canis virB10 and virB11 mutants in a murine model. Front Cell Infect Microbiol. 2012;2:35 pubmed publisher
    ..A non-polar virB10 mutant and a virB11 deletion mutant were constructed in Brucella canis. In the mouse model, both mutants were cleared at day 21 post-infection, indicating reduced virulence in mice...
  38. Boeri E, Escobar G, Ayala S, Sosa Estani S, Lucero N. [Canine brucellosis in dogs in the city of Buenos Aires]. Medicina (B Aires). 2008;68:291-7 pubmed
    Canine brucellosis, caused by Brucella canis, provokes epidydimitis, testicular atrophy and sterility in male dogs, while in females the major symptom is miscarriage...
  39. Kim J, Jeong W, Jeoung H, Song J, Kim H, Beak J, et al. Complete genome sequence of Brucella canis strain HSK A52141, isolated from the blood of an infected dog. J Bacteriol. 2012;194:5134 pubmed publisher
    b>Brucella canis infection can be clinically inapparent in dogs, and when infection goes unnoticed, there is a chance for dog-to-human transmission. A new strain of B...
  40. Wallach J, Giambartolomei G, Baldi P, Fossati C. Human infection with M- strain of Brucella canis. Emerg Infect Dis. 2004;10:146-8 pubmed
    The less mucoid strain of Brucella canis or M- strain is used for the serologic diagnosis of canine brucellosis...
  41. Barkha S, Dharmendra Kumar S, Dhirendra Kumar S. Immunochemical characterization of antigens of Brucella canis and their use in seroprevalence study of canine brucellosis. Asian Pac J Trop Med. 2011;4:857-61 pubmed publisher
    To explore immunochemical characterization of antigens of Brucella canis (B. canis), and the use in seroprevalence study of canine brucellosis...
  42. Cadmus S, Adesokan H, Ajala O, Odetokun W, Perrett L, Stack J. Seroprevalence of Brucella abortus and B. canis in household dogs in southwestern Nigeria: a preliminary report. J S Afr Vet Assoc. 2011;82:56-7 pubmed
    ..given the wide range of risk factors. Further studies are recommended to elucidate the epidemiology of brucellosis in dogs and its possible zoonotic consequences in the country...
  43. Castrillón Salazar L, Giraldo Echeverri C, Sánchez Jiménez M, Olivera Angel M. [Factors associated with Brucella canis seropositivity in kennels of two regions of Antioquia, Colombia]. Cad Saude Publica. 2013;29:1955-73 pubmed
    The objectives of this study were to determine Brucella canis seroprevalence in dogs and in humans living near kennels and to explore risk factors associated with seropositivity...
  44. Truong Q, Cho Y, Kim K, Park B, Hahn T. Booster vaccination with safe, modified, live-attenuated mutants of Brucella abortus strain RB51 vaccine confers protective immunity against virulent strains of B. abortus and Brucella canis in BALB/c mice. Microbiology. 2015;161:2137-48 pubmed publisher
    ..abortus strain 2308 or the heterologous Brucella canis strain 26...
  45. Yuksekkaya S, Aras Z, Uçan U. [Investigation of Brucella canis Seroprevalence in Brucellosis Suspected Cases]. Mikrobiyol Bul. 2013;47:152-7 pubmed
    b>Brucella canis which is the main etiologic agent of brucellosis in dogs, can be transmitted to man. It causes mild or asymptomatic infection in human compared with other Brucella species. B...
  46. Brower A, Lucero N, Okwumabua O, Groussaud P, Gopaul K, Whatmore A, et al. Newly identified variability in Brucella canis fatty-acid content is associated with geographical origin. Epidemiol Infect. 2013;141:852-8 pubmed publisher
    This study compared the fatty-acid profiles of Brucella canis blood culture isolates obtained from infected dogs in the UK, Germany, Japan, South Africa, Peru, Mexico, Colombia, and Argentina, and from a human clinical case in Argentina, ..
  47. Wang Y, Ke Y, Zhen Q, Yuan X, Xu J, Qiu Y, et al. Complete genome sequence of Brucella canis BCB018, a strain isolated from a human patient. J Bacteriol. 2012;194:6697-8 pubmed publisher
    b>Brucella canis is considered a rare cause of human brucellosis because of difficulties in presumptive diagnosis and underestimation of the incidence...
  48. Escobar G, Boeri E, Ayala S, Lucero N. The feasibility of using antigens prepared with rough Brucella strains for diagnosis of canine brucellosis. Rev Argent Microbiol. 2010;42:35-40 pubmed publisher
    ..Since Brucella canis shares antigenic components with the Brucella ovis and Brucella abortus RB51 strain, it would seem that either ..
  49. Adone R, Francia M, Ciuchini F. Brucella melitensis B115-based complement fixation test to detect antibodies induced by Brucella rough strains. J Appl Microbiol. 2008;105:567-74 pubmed publisher
    ..naturally devoid of anticomplementary activity, used as antigen in a complement fixation test (CFT) to detect antibodies induced by Brucella strains with rough phenotype, such as Brucella abortus RB51, Brucella ovis and Brucella canis.
  50. Usta M, Aras Z, Taş A. Oxidant and antioxidant parameters in patients with Brucella canis. Clin Biochem. 2012;45:366-7 pubmed publisher
    The aim of this study was to evaluate the oxidative status in patient with Brucella canis (B...
  51. Marzetti S, Carranza C, Roncallo M, Escobar G, Lucero N. Recent trends in human Brucella canis infection. Comp Immunol Microbiol Infect Dis. 2013;36:55-61 pubmed publisher
    ..We report Brucella canis human infection link to Gaucher's disease and Guillain Barré syndrome and discuss complications observed in a ..
  52. Gous T, van Rensburg W, Gray M, Perrett L, Brew S, Young E, et al. Brucella canis in South Africa. Vet Rec. 2005;157:668 pubmed
  53. Lopez G, Escobar G, Ayala S, Lucero N. Detection of antibodies to Brucella ovis in sheep milk using B. ovis and B. canis antigen. Vet Microbiol. 2006;116:232-8 pubmed
    ..of milk and sera from lactating ewes, comparing bacteriological studies, serological and milk tests using Brucella canis and B. ovis antigens...
  54. Gyuranecz M, Rannals B, Allen C, Jánosi S, KEIM P, Foster J. Within-host evolution of Brucella canis during a canine brucellosis outbreak in a kennel. BMC Vet Res. 2013;9:76 pubmed publisher
    ..The current study is the first to employ fine-scale genotyping on an isolate collection derived from a Brucella canis outbreak. Eight isolates of B...
  55. Clausse M, Díaz A, Ghersi G, Zylberman V, Cassataro J, Giambartolomei G, et al. The vaccine candidate BLSOmp31 protects mice against Brucella canis infection. Vaccine. 2013;31:6129-35 pubmed publisher
    ..New approaches are therefore urgently needed to develop an effective and safe immunization strategy against Brucella canis. In the present study, BALB/c mice were subcutaneously immunized with the recombinant chimera rBLSOmp31 ..
  56. Baek B, Park M, Islam M, Khatun M, Lee S, Boyle S. The first detection of Brucella canis in cattle in the Republic of Korea. Zoonoses Public Health. 2012;59:77-82 pubmed publisher
    ..canis strain. This is the first report of the occurrence of a B. canis infection in cattle in Korea. More survey data are needed to determine whether B. canis is a significant aetiology in the cases of cattle brucellosis in Korea...
  57. Barrouin Melo S, Poester F, Ribeiro M, de Alcantara A, Aguiar P, Nascimento I, et al. Diagnosis of canine brucellosis by ELISA using an antigen obtained from wild Brucella canis. Res Vet Sci. 2007;83:340-6 pubmed
    An indirect ELISA test was developed for the diagnosis of Brucella canis infection in dogs. A bacterial whole cell extract was used as a solid phase antigen, using B. canis isolated from an infected animal...
  58. Kimura M, Imaoka K, Suzuki M, Kamiyama T, Yamada A. Evaluation of a microplate agglutination test (MAT) for serological diagnosis of canine brucellosis. J Vet Med Sci. 2008;70:707-9 pubmed
    ..test (MAT) was compared with the tube agglutinin test (TAT), a standard test for the diagnosis of Brucella canis, in terms of the sensitivity and specificity...
  59. Hofer E, Bag Z, Revilla Fern Ndez S, Melzer F, Tomaso H, L Pez Go I I, et al. First detection of Brucella canis infections in a breeding kennel in Austria. New Microbiol. 2012;35:507-10 pubmed
    b>Brucella canis occurs almost worldwide and is a potential danger to the health of dogs and humans. The pathogen was detected in the placenta and fetuses of a Standard Poodle by direct culture and immunohistochemistry...
  60. Sayan M, Erdenlig S, Etiler N. [Investigation of Brucella canis seropositivity by in-house slide agglutination test antigen in healthy blood donors]. Mikrobiyol Bul. 2011;45:655-63 pubmed
    Canine brucellosis which is due to Brucella canis, is transmitted to man by infected dogs or their secretions...
  61. Soloaga R, Salinas A, Poterallo M, Margari A, Suar B, Lucero N, et al. [Bacteremia by Brucella canis. Isolation with the Bact-Alert system]. Rev Argent Microbiol. 2004;36:81-4 pubmed
    b>Brucella canis and other species of the genus Brucella can cause human disease. However, this species infrequently cause human disease, including in countries where dogs population is highly infected...
  62. Reynes E, LOPEZ G, Ayala S, Hunter G, Lucero N. Monitoring infected dogs after a canine brucellosis outbreak. Comp Immunol Microbiol Infect Dis. 2012;35:533-7 pubmed publisher
    ..In an effort to protect the public, stray dogs should be controlled and educational programs about the risk of this zoonotic disease should be implemented...
  63. Hinic V, Brodard I, Thomann A, Cvetnic Z, Makaya P, Frey J, et al. Novel identification and differentiation of Brucella melitensis, B. abortus, B. suis, B. ovis, B. canis, and B. neotomae suitable for both conventional and real-time PCR systems. J Microbiol Methods. 2008;75:375-8 pubmed publisher
    ..The assay has proven to be highly specific with the additional advantage of being suitable for use with both conventional and real-time PCR...
  64. Manias V, Nagel A, Mollerach A, Mendosa M, Freyre H, Gómez A, et al. [Brucella canis endocarditis: first documented case in Argentina]. Rev Argent Microbiol. 2013;45:50-3 pubmed
    ..The strain was sent to the INEI-ANLIS "Dr. Carlos G. Malbrán" where it was identified as Brucella canis. The antimicrobial treatment was switched to doxycycline, rifampicin and trimethoprim-sulfamethoxazole with ..
  65. de la Cuesta Zuluaga J, Sánchez Jiménez M, Martínez Garro J, Olivera Angel M. Identification of the virB operon genes encoding the type IV secretion system, in Colombian Brucella canis isolates. Vet Microbiol. 2013;163:196-9 pubmed publisher
    Canine brucellosis is a zoonotic disease caused by Brucella canis. The establishment of intracellular replicative niches of B. canis is mediated by proteins secreted by the type IV secretion system, which is encoded by the virB operon...
  66. Taques I, Barbosa T, Martini A, Pitchenin L, Braga I, de Melo A, et al. Molecular assessment of the transplacental transmission of Toxoplasma gondii, Neospora caninum, Brucella canis and Ehrlichia canis in dogs. Comp Immunol Microbiol Infect Dis. 2016;49:47-50 pubmed publisher
    ..detected in pregnant female dogs, the objective of this study was to assess the transplacental transmission of Brucella canis, Ehrlichia canis, Neospora caninum and Toxoplasma gondii in stillborn puppies...
  67. Oliveira Filho E, Pinheiro J, Souza M, Santana V, Silva J, Mota R, et al. Serologic survey of brucellosis in captive neotropical wild carnivores in northeast Brazil. J Zoo Wildl Med. 2012;43:384-7 pubmed
    ..antibodies in captive carnivores from Brazil, as well as the first report of antibodies to Brucella spp. in coatis, crab-eating raccoons, hoary foxes, little spotted cats, tayras, and greater grisons...
  68. Marley M, Rynders P. Theriogenology question of the month. The infected bitch should be euthanized. The other dogs in the kennel should be quarantined. J Am Vet Med Assoc. 2007;231:867-9 pubmed
  69. Fernández A, Hielpos M, Ferrero M, Fossati C, Baldi P. Proinflammatory response of canine trophoblasts to Brucella canis infection. PLoS ONE. 2017;12:e0186561 pubmed publisher
    b>Brucella canis infection is an important cause of late-term abortion in pregnant bitches. The pathophysiological mechanisms leading to B. canis-induced abortion are unknown, but heavily infected trophoblasts are consistently observed...