bordetella pertussis

Summary

Summary: A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.

Top Publications

  1. Lavine J, King A, Bjørnstad O. Natural immune boosting in pertussis dynamics and the potential for long-term vaccine failure. Proc Natl Acad Sci U S A. 2011;108:7259-64 pubmed publisher
    ..in the pre- and postvaccine eras, and (iv) the apparent shift from susceptible-infectious-recovered (SIR)-like to susceptible-infectious-recovered-susceptible (SIRS)-like phenomenology of infection and immunity to Bordetella pertussis.
  2. Han H, Kuwae A, Abe A, Arakawa Y, Kamachi K. Differential expression of type III effector BteA protein due to IS481 insertion in Bordetella pertussis. PLoS ONE. 2011;6:e17797 pubmed publisher
    b>Bordetella pertussis is the primary etiologic agent of the disease pertussis...
  3. Feunou P, Kammoun H, Debrie A, Mielcarek N, Locht C. Long-term immunity against pertussis induced by a single nasal administration of live attenuated B. pertussis BPZE1. Vaccine. 2010;28:7047-53 pubmed publisher
    ..live vaccine, named BPZE1, which has been shown to be safe and to induce strong protective immunity against Bordetella pertussis infection in mice...
  4. Kretzschmar M, Teunis P, Pebody R. Incidence and reproduction numbers of pertussis: estimates from serological and social contact data in five European countries. PLoS Med. 2010;7:e1000291 pubmed publisher
    ..discussed for the failure of vaccination to eliminate the disease is continued circulation of the pathogen Bordetella pertussis by mostly asymptomatic and mild infections in adolescents and adults...
  5. Heininger U, Riffelmann M, Bär G, Rudin C, von König C. The protective role of maternally derived antibodies against Bordetella pertussis in young infants. Pediatr Infect Dis J. 2013;32:695-8 pubmed publisher
  6. Subrini O, Sotomayor P rez A, Hessel A, Spiaczka Karst J, Selwa E, Sapay N, et al. Characterization of a membrane-active peptide from the Bordetella pertussis CyaA toxin. J Biol Chem. 2013;288:32585-98 pubmed publisher
    b>Bordetella pertussis, the pathogenic bacteria responsible for whooping cough, secretes several virulence factors, among which is the adenylate cyclase toxin (CyaA) that plays a crucial role in the early stages of human respiratory tract ..
  7. Rendi Wagner P, Tobias J, Moerman L, Goren S, Bassal R, Green M, et al. The seroepidemiology of Bordetella pertussis in Israel--Estimate of incidence of infection. Vaccine. 2010;28:3285-90 pubmed publisher
    This study was undertaken to estimate the magnitude of Bordetella pertussis infections in a highly vaccinated population in Israel in order to evaluate the relationship between clinical notification data and serology-based evidence of ..
  8. Veneziano R, Rossi C, Chenal A, Devoisselle J, Ladant D, Chopineau J. Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer. Proc Natl Acad Sci U S A. 2013;110:20473-8 pubmed publisher
    ..Our model toxin, the adenylate cyclase (CyaA) from Bordetella pertussis, is able to invade eukaryotic cells by translocating its catalytic domain directly across the plasma ..
  9. Bart M, van Gent M, van der Heide H, Boekhorst J, Hermans P, Parkhill J, et al. Comparative genomics of prevaccination and modern Bordetella pertussis strains. BMC Genomics. 2010;11:627 pubmed publisher
    ..The resurgence of pertussis has been associated with the expansion of Bordetella pertussis strains with a novel allele for the pertussis toxin (Ptx) promoter, ptxP3, which have replaced resident ..

More Information

Publications100

  1. Karst J, BARKER R, Devi U, Swann M, Davi M, Roser S, et al. Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin. J Biol Chem. 2012;287:9200-12 pubmed publisher
    The adenylate cyclase (CyaA) toxin, one of the virulence factors secreted by Bordetella pertussis, the pathogenic bacteria responsible for whooping cough, plays a critical role in the early stages of respiratory tract colonization by this ..
  2. Shuel M, Jamieson F, Tang P, Brown S, Farrell D, Martin I, et al. Genetic analysis of Bordetella pertussis in Ontario, Canada reveals one predominant clone. Int J Infect Dis. 2013;17:e413-7 pubmed publisher
    To characterize Bordetella pertussis isolates in Ontario, Canada in order to understand the clonal diversity of strains present in this province.
  3. Geduhn J, Dove S, Shen Y, Tang W, Konig B, Seifert R. Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin. J Pharmacol Exp Ther. 2011;336:104-15 pubmed publisher
    Whooping cough is caused by Bordetella pertussis and still constitutes one of the top five causes of death in young children, particularly in developing countries...
  4. Hallander H, Andersson M, Gustafsson L, Ljungman M, Netterlid E. Seroprevalence of pertussis antitoxin (anti-PT) in Sweden before and 10 years after the introduction of a universal childhood pertussis vaccination program. APMIS. 2009;117:912-22 pubmed publisher
    ..The results indicate a reduced exposure to Bordetella pertussis in the population...
  5. Boulanger A, Chen Q, Hinton D, Stibitz S. In vivo phosphorylation dynamics of the Bordetella pertussis virulence-controlling response regulator BvgA. Mol Microbiol. 2013;88:156-72 pubmed publisher
    ..us to readily ascertain the degree of phosphorylation of BvgA in in vitro reactions, or in crude lysates of Bordetella pertussis grown under varying laboratory conditions...
  6. Carbonetti N. Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools. Future Microbiol. 2010;5:455-69 pubmed publisher
    Pertussis toxin and adenylate cyclase toxin are two important virulence factors of Bordetella pertussis, the bacterial cause of the respiratory disease pertussis or whooping cough...
  7. Kallonen T, He Q. Bordetella pertussis strain variation and evolution postvaccination. Expert Rev Vaccines. 2009;8:863-75 pubmed publisher
    b>Bordetella pertussis is a Gram-negative bacterium that causes pertussis or whooping cough in humans...
  8. Bibova I, Skopova K, Masin J, Cerny O, Hot D, Sebo P, et al. The RNA chaperone Hfq is required for virulence of Bordetella pertussis. Infect Immun. 2013;81:4081-90 pubmed publisher
    b>Bordetella pertussis is a Gram-negative pathogen causing the human respiratory disease called pertussis or whooping cough. Here we examined the role of the RNA chaperone Hfq in B. pertussis virulence...
  9. Nakamura Y, Kamachi K, Toyoizumi Ajisaka H, Otsuka N, Saito R, Tsuruoka J, et al. Marked difference between adults and children in Bordetella pertussis DNA load in nasopharyngeal swabs. Clin Microbiol Infect. 2011;17:365-70 pubmed publisher
    b>Bordetella pertussis is the aetiologic agent of whooping cough, a common cause of severe respiratory illness in children and prolonged mild cough in adults...
  10. Gaillard M, Bottero D, Castuma C, Basile L, Hozbor D. Laboratory adaptation of Bordetella pertussis is associated with the loss of type three secretion system functionality. Infect Immun. 2011;79:3677-82 pubmed publisher
    Although Bordetella pertussis contains and transcribes loci encoding type III secretion system (TTSS) homologues, expression of TTSS-associated proteins has been reported only for non-laboratory-adapted Irish clinical isolates...
  11. Cornia P, Hersh A, Lipsky B, Newman T, Gonzales R. Does this coughing adolescent or adult patient have pertussis?. JAMA. 2010;304:890-6 pubmed publisher
    ..The presence or absence of posttussive emesis or inspiratory whoop modestly change the likelihood of pertussis; therefore, clinicians must use their overall clinical impression to decide about additional testing or empirical treatment. ..
  12. Bottero D, Griffith M, Lara C, Flores D, Pianciola L, Gaillard M, et al. Bordetella holmesii in children suspected of pertussis in Argentina. Epidemiol Infect. 2013;141:714-7 pubmed publisher
    ..Most patients reported cough and cold symptoms. No death was reported. We report B. holmesii isolation in infants with respiratory symptoms in Argentina...
  13. Dakic G, Kallonen T, Elomaa A, Pljesa T, Vignjevic Krastavcevic M, He Q. Bordetella pertussis vaccine strains and circulating isolates in Serbia. Vaccine. 2010;28:1188-92 pubmed publisher
    ..Current composition of the vaccine has been used since 1985 and contains four autochthonous strains of Bordetella pertussis isolated from 1957 to 1984...
  14. Broutin H, Viboud C, Grenfell B, Miller M, Rohani P. Impact of vaccination and birth rate on the epidemiology of pertussis: a comparative study in 64 countries. Proc Biol Sci. 2010;277:3239-45 pubmed publisher
    b>Bordetella pertussis infection remains an important public health problem worldwide despite decades of routine vaccination...
  15. Skerry C, Cassidy J, English K, Feunou Feunou P, Locht C, Mahon B. A live attenuated Bordetella pertussis candidate vaccine does not cause disseminating infection in gamma interferon receptor knockout mice. Clin Vaccine Immunol. 2009;16:1344-51 pubmed publisher
    b>Bordetella pertussis is the cause of whooping cough and responsible for 300,000 infant deaths per annum. Current vaccines require 6 months to confer optimal immunity on infants, the population at highest risk...
  16. Skerry C, Mahon B. A live, attenuated Bordetella pertussis vaccine provides long-term protection against virulent challenge in a murine model. Clin Vaccine Immunol. 2011;18:187-93 pubmed publisher
    ..high levels of gamma interferon (IFN-?), could be detected from spleen cells restimulated with inactivated Bordetella pertussis. BPZE1 induced low levels of interleukin-17 (IL-17) and no IL-10 or IL-5...
  17. Lavine J, Broutin H, Harvill E, Bjørnstad O. Imperfect vaccine-induced immunity and whooping cough transmission to infants. Vaccine. 2010;29:11-6 pubmed publisher
    ..In addition, the data indicate that the B. pertussis vaccine is not protective against disease induced by B. parapertussis. ..
  18. Zhang X, Hester S, Kennett M, Karanikas A, Bendor L, Place D, et al. Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis. Infect Immun. 2011;79:527-41 pubmed publisher
    ..better define the role of IL-1R in immunity to respiratory infections, we challenged IL-1R(-/-) mice with Bordetella pertussis and Bordetella parapertussis, the causative agents of whooping cough. Following inoculation with B...
  19. Tatti K, Sparks K, Boney K, Tondella M. Novel multitarget real-time PCR assay for rapid detection of Bordetella species in clinical specimens. J Clin Microbiol. 2011;49:4059-66 pubmed publisher
    A novel multitarget real-time PCR (RT-PCR) assay for the rapid identification of Bordetella pertussis, B. parapertussis, and B...
  20. Fedele G, Bianco M, Ausiello C. The virulence factors of Bordetella pertussis: talented modulators of host immune response. Arch Immunol Ther Exp (Warsz). 2013;61:445-57 pubmed publisher
    ..Although several types of vaccines are licensed and widely used, Bordetella pertussis continues to circulate in populations with high vaccine coverage of infants and children due to the waning ..
  21. Syed M, Ahmed W, Naeem A, Bokhari H. Seroprevalence of Bordetella pertussis antibodies to pertussis toxin among healthy children. J Coll Physicians Surg Pak. 2012;22:677-8 pubmed publisher
    ..cough is a highly communicable, vaccine-preventable acute respiratory tract disease, caused mainly by Bordetella pertussis. In this study, serosurveillance of IgG antibodies against pertussis toxin was carried out in healthy ..
  22. Vukman K, Ravidà A, Aldridge A, O Neill S. Mannose receptor and macrophage galactose-type lectin are involved in Bordetella pertussis mast cell interaction. J Leukoc Biol. 2013;94:439-48 pubmed publisher
    Mast cells are crucial in the development of immunity against Bordetella pertussis, and the function of TLRs in this process has been investigated. Here, the interaction between mast cells and B...
  23. Holberg Petersen M, Jenum P, Mannsåker T, Melby K. Comparison of PCR with culture applied on nasopharyngeal and throat swab specimens for the detection of Bordetella pertussis. Scand J Infect Dis. 2011;43:221-4 pubmed publisher
    An in-house nested polymerase chain reaction (PCR) was prospectively compared with culture for Bordetella pertussis detection in 435 nasopharyngeal and/or throat swabs from 304 patients...
  24. Soria Guerra R, Rosales Mendoza S, Moreno Fierros L, López Revilla R, Alpuche Solís A. Oral immunogenicity of tomato-derived sDPT polypeptide containing Corynebacterium diphtheriae, Bordetella pertussis and Clostridium tetani exotoxin epitopes. Plant Cell Rep. 2011;30:417-24 pubmed publisher
    ..These findings support the concept of using transgenic tomatoes expressing sDPT polypeptide as model for edible vaccine against diphtheria, pertussis, and tetanus...
  25. Schnoeller C, Roux X, Sawant D, Raze D, Olszewska W, Locht C, et al. Attenuated Bordetella pertussis vaccine protects against respiratory syncytial virus disease via an IL-17-dependent mechanism. Am J Respir Crit Care Med. 2014;189:194-202 pubmed publisher
    We attenuated virulent Bordetella pertussis by genetically eliminating or detoxifying three major toxins. This strain, named BPZE1, is being developed as a possible live nasal vaccine for the prevention of whooping cough...
  26. van de Waterbeemd B, Streefland M, Pennings J, van der Pol L, Beuvery C, Tramper J, et al. Gene-expression-based quality scores indicate optimal harvest point in Bordetella pertussis cultivation for vaccine production. Biotechnol Bioeng. 2009;103:900-8 pubmed publisher
    The evolution of vaccine product quality during batch cultivation of Bordetella pertussis, the causative agent of whooping cough, was investigated with the goal to determine the optimal harvest point...
  27. Zhang S, Xu Y, Zhou Z, Wang S, Yang R, Wang J, et al. Complete genome sequence of Bordetella pertussis CS, a Chinese pertussis vaccine strain. J Bacteriol. 2011;193:4017-8 pubmed publisher
    b>Bordetella pertussis is the causative agent of pertussis...
  28. Schneider O, Weiss A, Miller W. Pertussis toxin signals through the TCR to initiate cross-desensitization of the chemokine receptor CXCR4. J Immunol. 2009;182:5730-9 pubmed publisher
    ..These data suggest that TCR crosstalk with CXCR4 is likely a normal cellular process that leads to cross-desensitization, which is exploited by the B subunit of PTx...
  29. Ross P, Sutton C, Higgins S, Allen A, Walsh K, Misiak A, et al. Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine. PLoS Pathog. 2013;9:e1003264 pubmed publisher
    Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa)...
  30. Gray M, Hewlett E. Cell cycle arrest induced by the bacterial adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Cell Microbiol. 2011;13:123-34 pubmed publisher
    Bacillus anthracis oedema toxin (ET) and Bordetella pertussis adenylate cyclase toxin (ACT) enter host cells and produce cAMP...
  31. Noofeli M, Bokhari H, Blackburn P, Roberts M, Coote J, Parton R. BapC autotransporter protein is a virulence determinant of Bordetella pertussis. Microb Pathog. 2011;51:169-77 pubmed publisher
    ..AF081494) or BapC (GenBank accession no. AJ277634) has been identified as a member of the Bordetella pertussis autotransporter family and the present work suggests that this protein, like the previously characterised ..
  32. Li R, Lim A, Ow S, Phoon M, Locht C, Chow V, et al. Development of live attenuated Bordetella pertussis strains expressing the universal influenza vaccine candidate M2e. Vaccine. 2011;29:5502-11 pubmed publisher
    The attenuated Bordetella pertussis BPZE1 vaccine strain represents an attractive platform for the delivery of heterologous vaccine candidates via the nasal route...
  33. van Gent M, Bart M, van der Heide H, Heuvelman K, Mooi F. Small mutations in Bordetella pertussis are associated with selective sweeps. PLoS ONE. 2012;7:e46407 pubmed publisher
    b>Bordetella pertussis is the causative agent of pertussis, a highly contagious disease of the human respiratory tract...
  34. Advani A, Hallander H, Dalby T, Krogfelt K, Guiso N, Njamkepo E, et al. Pulsed-field gel electrophoresis analysis of Bordetella pertussis isolates circulating in Europe from 1998 to 2009. J Clin Microbiol. 2013;51:422-8 pubmed publisher
    Between 1998 and 2009, Bordetella pertussis clinical isolates were collected during three periods, i.e., 1998 to 2001 (n = 102), 2004 to 2005 (n = 154), and 2007 to 2009 (n = 140), from nine countries with distinct vaccination programs, i...
  35. Li R, Cheng C, Chong S, Lim A, Goh Y, Locht C, et al. Attenuated Bordetella pertussis BPZE1 protects against allergic airway inflammation and contact dermatitis in mouse models. Allergy. 2012;67:1250-8 pubmed publisher
    We previously reported that prior nasal administration of highly attenuated Bordetella pertussis BPZE1 provides effective and sustained protection against lethal challenge with influenza A viruses...
  36. Zhang X, Goel T, Goodfield L, Muse S, Harvill E. Decreased leukocyte accumulation and delayed Bordetella pertussis clearance in IL-6-/- mice. J Immunol. 2011;186:4895-904 pubmed publisher
    ..that IL-6 influences the adaptive immune responses against the endemic human respiratory pathogen Bordetella pertussis. IL-6 was induced in the lungs of C57BL/6 mice by B. pertussis...
  37. van Gent M, Bart M, van der Heide H, Heuvelman K, Kallonen T, He Q, et al. SNP-based typing: a useful tool to study Bordetella pertussis populations. PLoS ONE. 2011;6:e20340 pubmed publisher
    To monitor changes in Bordetella pertussis populations, mainly two typing methods are used; Pulsed-Field Gel Electrophoresis (PFGE) and Multiple-Locus Variable-Number Tandem Repeat Analysis (MLVA)...
  38. Schmidtke A, Boney K, Martin S, Skoff T, Tondella M, Tatti K. Population diversity among Bordetella pertussis isolates, United States, 1935-2009. Emerg Infect Dis. 2012;18:1248-55 pubmed publisher
    ..Since the 1980s, pertussis notifications in the United States have been increasing. To determine the types of Bordetella pertussis responsible for these increases, we divided 661 B...
  39. Asensio C, Gaillard M, Moreno G, Bottero D, Zurita E, Rumbo M, et al. Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate. Vaccine. 2011;29:1649-56 pubmed publisher
    ..The pagL gene from Bordetella bronchiseptica, which encodes a lipid A 3-deacylase, was expressed in Bordetella pertussis strain Tohama I...
  40. Advani A, van der Heide H, Hallander H, Mooi F. Analysis of Swedish Bordetella pertussis isolates with three typing methods: characterization of an epidemic lineage. J Microbiol Methods. 2009;78:297-301 pubmed publisher
    Three Bordetella pertussis typing methods, pulsed-field gel electrophoresis (PFGE), multi-locus sequence typing (MLST), and multi-locus variable number tandem repeat analysis (MLVA) were compared using a collection of Swedish strains...
  41. Wearing H, Rohani P. Estimating the duration of pertussis immunity using epidemiological signatures. PLoS Pathog. 2009;5:e1000647 pubmed publisher
    ..Our results support a period of natural immunity that is, on average, long-lasting (at least 30 years) but inherently variable...
  42. Berbers G, de Greeff S, Mooi F. Improving pertussis vaccination. Hum Vaccin. 2009;5:497-503 pubmed
  43. Ghanaie R, Karimi A, Sadeghi H, Esteghamti A, Falah F, Armin S, et al. Sensitivity and specificity of the World Health Organization pertussis clinical case definition. Int J Infect Dis. 2010;14:e1072-5 pubmed publisher
    b>Bordetella pertussis continues to circulate even in countries with good childhood vaccination coverage...
  44. Fransen F, Stenger R, Poelen M, van Dijken H, Kuipers B, Boog C, et al. Differential effect of TLR2 and TLR4 on the immune response after immunization with a vaccine against Neisseria meningitidis or Bordetella pertussis. PLoS ONE. 2010;5:e15692 pubmed publisher
    Neisseria meningitidis and Bordetella pertussis are Gram-negative bacterial pathogens that can cause serious diseases in humans. N...
  45. Sugisaki K, Hanawa T, Yonezawa H, Osaki T, Fukutomi T, Kawakami H, et al. Role of (p)ppGpp in biofilm formation and expression of filamentous structures in Bordetella pertussis. Microbiology. 2013;159:1379-89 pubmed publisher
    b>Bordetella pertussis, the causative agent of whooping cough, is highly adapted to cause human infection. The production of virulence factors, such as adhesins and toxins, is just part of an array of mechanisms by which B...
  46. Moreno G, Errea A, Van Maele L, Roberts R, Leger H, Sirard J, et al. Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection. Microbes Infect. 2013;15:708-18 pubmed publisher
    Most of the knowledge on the impact of Bordetella pertussis lipo-oligosaccharide (LOS) on the infectious process was obtained when the bacteria was established within the host...
  47. Lamberti Y, Hayes J, Perez Vidakovics M, Harvill E, Rodriguez M. Intracellular trafficking of Bordetella pertussis in human macrophages. Infect Immun. 2010;78:907-13 pubmed publisher
    Although Bordetella pertussis has been observed to survive inside macrophages, its ability to resist or evade degradation in phagolysosomes has not been defined. We here investigated the trafficking of B...
  48. Hegerle N, Paris A, Brun D, Dore G, Njamkepo E, Guillot S, et al. Evolution of French Bordetella pertussis and Bordetella parapertussis isolates: increase of Bordetellae not expressing pertactin. Clin Microbiol Infect. 2012;18:E340-6 pubmed publisher
    b>Bordetella pertussis and Bordetella parapertussis are closely related bacterial agents of whooping cough. Whole-cell pertussis (wP) vaccine was introduced in France in 1959...
  49. Komatsu E, Yamaguchi F, Abe A, Weiss A, Watanabe M. Synergic effect of genotype changes in pertussis toxin and pertactin on adaptation to an acellular pertussis vaccine in the murine intranasal challenge model. Clin Vaccine Immunol. 2010;17:807-12 pubmed publisher
    The Bordetella pertussis pertussis toxin and pertactin (Prn) are protective antigens and are contained in acellular pertussis vaccines...
  50. Quinello C, Quintilio W, Carneiro Sampaio M, Palmeira P. Passive acquisition of protective antibodies reactive with Bordetella pertussis in newborns via placental transfer and breast-feeding. Scand J Immunol. 2010;72:66-73 pubmed publisher
    ..bacterial pathogenicity in an in vivo experimental model using mice intracerebrally challenged with viable Bordetella pertussis. Forty paired samples of maternal/umbilical cord sera and colostrum were obtained...
  51. Miyaji Y, Otsuka N, Toyoizumi Ajisaka H, Shibayama K, Kamachi K. Genetic analysis of Bordetella pertussis isolates from the 2008-2010 pertussis epidemic in Japan. PLoS ONE. 2013;8:e77165 pubmed publisher
    ..To investigate epidemic strains, we analyzed 33 Bordetella pertussis isolates from the epidemic period by sequencing virulence-associated genes (fim3, ptxP, ptxA, and prn) and ..
  52. Fedele G, Bianco M, Debrie A, Locht C, Ausiello C. Attenuated Bordetella pertussis vaccine candidate BPZE1 promotes human dendritic cell CCL21-induced migration and drives a Th1/Th17 response. J Immunol. 2011;186:5388-96 pubmed publisher
    ..A novel live attenuated Bordetella pertussis vaccine strain, BPZE1, has been developed by eliminating or detoxifying three important B...
  53. Bokhari H, Said F, Syed M, Mughal A, Kazi Y, Heuvelman K, et al. Whooping cough in Pakistan: Bordetella pertussis vs Bordetella parapertussis in 2005-2009. Scand J Infect Dis. 2011;43:818-20 pubmed publisher
    ..or whooping cough, is an acute respiratory disease mainly affecting infants and children and is caused by Bordetella pertussis and Bordetella parapertussis...
  54. van Gent M, de Greeff S, van der Heide H, Mooi F. An investigation into the cause of the 1983 whooping cough epidemic in the Netherlands. Vaccine. 2009;27:1898-903 pubmed publisher
    ..of this study was to reinvestigate the causes of the increased notifications by identifying changes in the Bordetella pertussis population. B...
  55. Nuolivirta K, Koponen P, He Q, Halkosalo A, Korppi M, Vesikari T, et al. Bordetella pertussis infection is common in nonvaccinated infants admitted for bronchiolitis. Pediatr Infect Dis J. 2010;29:1013-5 pubmed
    ..Preliminary evidence suggests that viral-pertussis coinfections are common in nonvaccinated infants...
  56. Marr N, Hajjar A, Shah N, Novikov A, Yam C, Caroff M, et al. Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14. Infect Immun. 2010;78:2060-9 pubmed publisher
    b>Bordetella pertussis endotoxin is a key modulator of the host immune response, mainly due to the role of its lipid A moiety in Toll-like receptor 4 (TLR4)-mediated signaling...
  57. Lam C, Octavia S, Bahrame Z, Sintchenko V, Gilbert G, Lan R. Selection and emergence of pertussis toxin promoter ptxP3 allele in the evolution of Bordetella pertussis. Infect Genet Evol. 2012;12:492-5 pubmed publisher
    Evolutionary studies using single nucleotide polymorphisms (SNPs) have separated Bordetella pertussis isolates into six major clusters, with recent isolates forming cluster I...
  58. Kavanagh H, Noone C, Cahill E, English K, Locht C, Mahon B. Attenuated Bordetella pertussis vaccine strain BPZE1 modulates allergen-induced immunity and prevents allergic pulmonary pathology in a murine model. Clin Exp Allergy. 2010;40:933-41 pubmed publisher
    Virulent Bordetella pertussis, the causative agent of whooping cough, exacerbates allergic airway inflammation in a murine model of ovalbumin (OVA) sensitization. A live genetically attenuated B...
  59. Quinn H, McIntyre P. The impact of adolescent pertussis immunization, 2004-2009: lessons from Australia. Bull World Health Organ. 2011;89:666-74 pubmed publisher
  60. Advani A, Gustafsson L, Ahrén C, Mooi F, Hallander H. Appearance of Fim3 and ptxP3-Bordetella pertussis strains, in two regions of Sweden with different vaccination programs. Vaccine. 2011;29:3438-42 pubmed publisher
    ..To investigate a possible cause of this difference, the Bordetella pertussis populations in both regions were compared by determining the fimbrial serotype (Fim), the PFGE-type and the ..
  61. Hot D, Slupek S, Wulbrecht B, D Hondt A, Hubans C, Antoine R, et al. Detection of small RNAs in Bordetella pertussis and identification of a novel repeated genetic element. BMC Genomics. 2011;12:207 pubmed publisher
    ..So far, little is known about sRNAs in Bordetella, and only very few sRNAs have been identified in the genome of Bordetella pertussis, the causative agent of whooping cough.
  62. Dirix V, Verscheure V, Goetghebuer T, Hainaut M, Debrie A, Locht C, et al. Monocyte-derived interleukin-10 depresses the Bordetella pertussis- specific gamma interferon response in vaccinated infants. Clin Vaccine Immunol. 2009;16:1816-21 pubmed publisher
    Antigen-specific gamma interferon (IFN-gamma) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B...
  63. Haberling D, Holman R, Paddock C, Murphy T. Infant and maternal risk factors for pertussis-related infant mortality in the United States, 1999 to 2004. Pediatr Infect Dis J. 2009;28:194-8 pubmed publisher
    ..Infants aged <12 months have the highest rates of complications and death from pertussis of any age group. Factors that increase the risk of pertussis-related death in infants are not well defined...
  64. Nar Otgun S, Durmaz R, Karagoz A, Esen B, Ertek M. Pulsed-field gel electrophoresis characterization of Bordetella pertussis clinical isolates circulating in Turkey in 2001-2009. Eur J Clin Microbiol Infect Dis. 2011;30:1229-36 pubmed publisher
    Our purpose was to evaluate the natural epidemiological history of circulating Bordetella pertussis clinical isolates in Turkey, comparing isolates by means of pulsed-field gel electrophoresis (PFGE) profiles according to years, ..
  65. Coleman M, Finlay C, Moran B, Keane J, Dunne P, Mills K. The immunoregulatory role of CD4? FoxP3? CD25? regulatory T cells in lungs of mice infected with Bordetella pertussis. FEMS Immunol Med Microbiol. 2012;64:413-24 pubmed publisher
    ..In this study, we used a murine model of respiratory infection with Bordetella pertussis to examine the role of Treg cells in protective immunity in the lung...
  66. Conover M, Mishra M, Deora R. Extracellular DNA is essential for maintaining Bordetella biofilm integrity on abiotic surfaces and in the upper respiratory tract of mice. PLoS ONE. 2011;6:e16861 pubmed publisher
    ..a biofilm mode of existence in vivo, the gram negative bacterial pathogens Bordetella bronchiseptica and Bordetella pertussis are able to efficiently colonize and persist in the mammalian respiratory tract...
  67. Zouari A, Smaoui H, Brun D, Njamkepo E, Sghaier S, Zouari E, et al. Prevalence of Bordetella pertussis and Bordetella parapertussis infections in Tunisian hospitalized infants: results of a 4-year prospective study. Diagn Microbiol Infect Dis. 2012;72:303-17 pubmed publisher
    ..for the first time in a Tunisian prospective study in order to get a first estimation of the prevalence of Bordetella pertussis/parapertussis infections and to evaluate their use to determine the epidemiologic characteristics of these ..
  68. Dalby T, Petersen J, Harboe Z, Krogfelt K. Antibody responses to pertussis toxin display different kinetics after clinical Bordetella pertussis infection than after vaccination with an acellular pertussis vaccine. J Med Microbiol. 2010;59:1029-36 pubmed publisher
    ..ELISA is a frequently used method for studying the antibody responses after pertussis vaccination and after Bordetella pertussis infection...
  69. Neo Y, Li R, Howe J, Hoo R, Pant A, Ho S, et al. Evidence for an intact polysaccharide capsule in Bordetella pertussis. Microbes Infect. 2010;12:238-45 pubmed publisher
    ..The production of a capsule in Bordetella pertussis, the etiologic agent of whooping cough, has remained controversial; earlier studies reported this pathogen ..
  70. Mielcarek N, Debrie A, Mahieux S, Locht C. Dose response of attenuated Bordetella pertussis BPZE1-induced protection in mice. Clin Vaccine Immunol. 2010;17:317-24 pubmed publisher
    ..As a potential solution to this problem, we have developed an attenuated live Bordetella pertussis vaccine strain, named BPZE1...
  71. King A, van der Lee S, Mohangoo A, van Gent M, van der Ark A, van de Waterbeemd B. Genome-wide gene expression analysis of Bordetella pertussis isolates associated with a resurgence in pertussis: elucidation of factors involved in the increased fitness of epidemic strains. PLoS ONE. 2013;8:e66150 pubmed publisher
    b>Bordetella pertussis (B. pertussis) is the causative agent of whooping cough, which is a highly contagious disease in the human respiratory tract...
  72. Vermeulen F, Verscheure V, Damis E, Vermeylen D, Leloux G, Dirix V, et al. Cellular immune responses of preterm infants after vaccination with whole-cell or acellular pertussis vaccines. Clin Vaccine Immunol. 2010;17:258-62 pubmed publisher
    Based on studies reporting specific antibody titers, it is recommended to vaccinate preterm infants against Bordetella pertussis according to their chronological age...
  73. Higgs R, Higgins S, Ross P, Mills K. Immunity to the respiratory pathogen Bordetella pertussis. Mucosal Immunol. 2012;5:485-500 pubmed publisher
    b>Bordetella pertussis causes whooping cough, a severe respiratory tract infection in infants and children, and also infects adults...
  74. Brickman T, Cummings C, Liew S, Relman D, Armstrong S. Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression. J Bacteriol. 2011;193:4798-812 pubmed publisher
    Serological studies of patients with pertussis and the identification of antigenic Bordetella pertussis proteins support the hypothesis that B...
  75. Li R, Lim A, Phoon M, Narasaraju T, Ng J, Poh W, et al. Attenuated Bordetella pertussis protects against highly pathogenic influenza A viruses by dampening the cytokine storm. J Virol. 2010;84:7105-13 pubmed publisher
    ..influenza virus-induced pneumonitis, we observed that prior nasal administration of an attenuated strain of Bordetella pertussis (BPZE1) provided effective and sustained protection against lethal challenge with two different influenza A ..
  76. Rossi Paccani S, Benagiano M, Capitani N, Zornetta I, Ladant D, Montecucco C, et al. The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling. PLoS Pathog. 2009;5:e1000325 pubmed publisher
    ..CD4(+) T cell differentiation of two adenylate cyclase toxins, Bacillus anthracis edema toxin (ET) and Bordetella pertussis CyaA, which differ in structure, mode of cell entry, and subcellular localization...
  77. Riffelmann M, Thiel K, Schmetz J, Wirsing von Koenig C. Performance of commercial enzyme-linked immunosorbent assays for detection of antibodies to Bordetella pertussis. J Clin Microbiol. 2010;48:4459-63 pubmed publisher
    Measuring antibodies to Bordetella pertussis antigens is mostly done by enzyme-linked immunosorbent assays (ELISAs). We compared the performance of ELISA kits that were commercially available in Germany...
  78. Elomaa A, He Q, Minh N, Mertsola J. Pertussis before and after the introduction of acellular pertussis vaccines in Finland. Vaccine. 2009;27:5443-9 pubmed publisher
    ..this study was to evaluate the effects of these changes on the epidemiology and strain characteristics of Bordetella pertussis. From the national register, we first analysed all the laboratory diagnosed cases during the study years in ..
  79. Bottero D, Gaillard M, Basile L, Fritz M, Hozbor D. Genotypic and phenotypic characterization of Bordetella pertussis strains used in different vaccine formulations in Latin America. J Appl Microbiol. 2012;112:1266-76 pubmed publisher
    To characterize Bordetella pertussis vaccine strains in comparison with current circulating bacteria.
  80. Quintilio W, Kubrusly F, Iourtov D, Miyaki C, Sakauchi M, Lúcio F, et al. Bordetella pertussis monophosphoryl lipid A as adjuvant for inactivated split virion influenza vaccine in mice. Vaccine. 2009;27:4219-24 pubmed publisher
    ..The use of adjuvants could increase several fold the current installed production capacity. Bordetella pertussis monophosphyl lipid A (MPLA) was produced by acid hydrolysis of LPS, obtained as a by-product of its removal ..
  81. Zhang X, Rodriguez M, Harvill E. O antigen allows B. parapertussis to evade B. pertussis vaccine-induced immunity by blocking binding and functions of cross-reactive antibodies. PLoS ONE. 2009;4:e6989 pubmed publisher
    ..parapertussis prevalence varies substantially between populations with different vaccination strategies...
  82. Rodgers L, Martin S, Cohn A, Budd J, Marcon M, Terranella A, et al. Epidemiologic and laboratory features of a large outbreak of pertussis-like illnesses associated with cocirculating Bordetella holmesii and Bordetella pertussis--Ohio, 2010-2011. Clin Infect Dis. 2013;56:322-31 pubmed publisher
    ..The majority of cases were identified by IS481-directed polymerase chain reaction (PCR), which does not differentiate among Bordetella species. We sought to determine outbreak etiology and epidemiologic characteristics...
  83. Hendrikx L, Oztürk K, de Rond L, Veenhoven R, Sanders E, Berbers G, et al. Identifying long-term memory B-cells in vaccinated children despite waning antibody levels specific for Bordetella pertussis proteins. Vaccine. 2011;29:1431-7 pubmed publisher
    Whooping cough is a respiratory disease caused by Bordetella pertussis. Since the 1950s in developed countries pertussis vaccinations are included in the national immunization program...
  84. Octavia S, Maharjan R, Sintchenko V, Stevenson G, Reeves P, Gilbert G, et al. Insight into evolution of Bordetella pertussis from comparative genomic analysis: evidence of vaccine-driven selection. Mol Biol Evol. 2011;28:707-15 pubmed publisher
    ..A significant factor that may be contributing to this increase is adaptation to the vaccine by Bordetella pertussis, the causative agent of pertussis. In this study, we first assessed the genetic diversity of B...
  85. Bouchez V, Brun D, Cantinelli T, Dore G, Njamkepo E, Guiso N. First report and detailed characterization of B. pertussis isolates not expressing Pertussis Toxin or Pertactin. Vaccine. 2009;27:6034-41 pubmed publisher
    b>Bordetella pertussis isolates not expressing Pertussis Toxin (PT) or Pertactin (PRN) have been collected, for the first time in 2007, in France, a highly vaccinated country with acellular vaccines...
  86. Shah N, AlBitar Nehmé S, Kim E, Marr N, Novikov A, Caroff M, et al. Minor modifications to the phosphate groups and the C3' acyl chain length of lipid A in two Bordetella pertussis strains, BP338 and 18-323, independently affect Toll-like receptor 4 protein activation. J Biol Chem. 2013;288:11751-60 pubmed publisher
    Lipopolysaccharides (LPS) of Bordetella pertussis are important modulators of the immune system...
  87. Abu Raya B, Bamberger E, Kassis I, Kugelman A, Srugo I, Miron D. Bordetella pertussis infection attenuates clinical course of acute bronchiolitis. Pediatr Infect Dis J. 2013;32:619-21 pubmed publisher
    b>Bordetella pertussis (BP) was detected in hospitalized children with various lower respiratory tract infections...
  88. Serra D, Conover M, Arnal L, Sloan G, Rodriguez M, Yantorno O, et al. FHA-mediated cell-substrate and cell-cell adhesions are critical for Bordetella pertussis biofilm formation on abiotic surfaces and in the mouse nose and the trachea. PLoS ONE. 2011;6:e28811 pubmed publisher
    ..These discoveries highlight FHA as a key factor in establishing structured biofilm communities in the respiratory tract...
  89. Zepp F, Heininger U, Mertsola J, Bernatowska E, Guiso N, Roord J, et al. Rationale for pertussis booster vaccination throughout life in Europe. Lancet Infect Dis. 2011;11:557-70 pubmed publisher
  90. Zhang L, Xu Y, Zhao J, Kallonen T, Cui S, Xu Y, et al. Effect of vaccination on Bordetella pertussis strains, China. Emerg Infect Dis. 2010;16:1695-701 pubmed publisher
    ..We used standard typing methods to compare 96 Bordetella pertussis isolates collected before and after introduction of vaccination, during 1953-2005...
  91. Sin M, Zenke R, Rönckendorf R, Littmann M, Jorgensen P, Hellenbrand W. Pertussis outbreak in primary and secondary schools in Ludwigslust, Germany demonstrating the role of waning immunity. Pediatr Infect Dis J. 2009;28:242-4 pubmed publisher
    ..Results suggested waning immunity beginning approximately 5 years after the last dose of pertussis vaccination. Most cases could have been prevented by earlier booster vaccination...