bordetella bronchiseptica

Summary

Summary: A species of BORDETELLA that is parasitic and pathogenic. It is found in the respiratory tract of domestic and wild mammalian animals and can be transmitted from animals to man. It is a common cause of bronchopneumonia in lower animals.

Top Publications

  1. Llombart M, Chiner E, Senent C. [Necrotizing pneumonia due to Bordetella bronchiseptica in an immunocompetent woman]. Arch Bronconeumol. 2006;42:255-6 pubmed
  2. Savelkoul P, de Kerf D, Willems R, Mooi F, van der Zeijst B, Gaastra W. Characterization of the fim2 and fim3 fimbrial subunit genes of Bordetella bronchiseptica: roles of Fim2 and Fim3 fimbriae and flagella in adhesion. Infect Immun. 1996;64:5098-105 pubmed
    ..from the fimbrial subunit genes fim2 and fim3 of Bordetella pertussis, two homologous subunit genes of Bordetella bronchiseptica were identified and cloned. The nucleotide sequences of these genes were determined...
  3. Kang M, Kang S, Jiang H, Guo D, Lee D, Rayamahji N, et al. Chitosan microspheres containing Bordetella bronchiseptica antigens as novel vaccine against atrophic rhinitis in pigs. J Microbiol Biotechnol. 2008;18:1179-85 pubmed
    The immune-stimulating activities of Bordetella bronchiseptica antigens containing dermonecrotoxin (BBD) loaded in chitosan microspheres (CMs) have already been reported in vitro and in vivo with a mouse alveolar macrophage cell line (..
  4. Ahuja U, Liu M, Tomida S, Park J, Souda P, Whitelegge J, et al. Phenotypic and genomic analysis of hypervirulent human-associated Bordetella bronchiseptica. BMC Microbiol. 2012;12:167 pubmed publisher
    ..Our observations reveal a T3SS-dependent hypervirulence phenotype in human-associated complex IV isolates, highlighting the need for further studies on the epidemiology and evolutionary dynamics of this B. bronchiseptica lineage. ..
  5. Lorenzo Pajuelo B, Villanueva J, Rodríguez Cuesta J, Vergara Irigaray N, Bernabeu Wittel M, García Curiel A, et al. Cavitary pneumonia in an AIDS patient caused by an unusual Bordetella bronchiseptica variant producing reduced amounts of pertactin and other major antigens. J Clin Microbiol. 2002;40:3146-54 pubmed
    Although Bordetella bronchiseptica can infect and colonize immunocompromised humans, its role as a primary pathogen in pneumonia and other respiratory processes affecting those patients remains controversial...
  6. Bock A, Gross R. The BvgAS two-component system of Bordetella spp.: a versatile modulator of virulence gene expression. Int J Med Microbiol. 2001;291:119-30 pubmed
    ..This review discusses the current knowledge about the molecular mechanisms of virulence regulation and their relevance for infection by these respiratory pathogens. ..
  7. Register K, DeJong K. Analytical verification of a multiplex PCR for identification of Bordetella bronchiseptica and Pasteurella multocida from swine. Vet Microbiol. 2006;117:201-10 pubmed
    b>Bordetella bronchiseptica and Pasteurella multocida are etiologic agents of progressive atrophic rhinitis (PAR) and bronchopneumonia in swine. Only dermonecrotic toxin-producing strains of P...
  8. Reissinger A, Skinner J, Yuk M. Downregulation of mitogen-activated protein kinases by the Bordetella bronchiseptica Type III secretion system leads to attenuated nonclassical macrophage activation. Infect Immun. 2005;73:308-16 pubmed
    b>Bordetella bronchiseptica utilizes a type III secretion system (TTSS) to establish a persistent infection of the murine respiratory tract...
  9. Gopinathan L, Kirimanjeswara G, Wolfe D, Kelley M, Harvill E. Different mechanisms of vaccine-induced and infection-induced immunity to Bordetella bronchiseptica. Microbes Infect. 2007;9:442-8 pubmed
    ..this work, we use a murine model of respiratory infection using the highly successful animal pathogen, Bordetella bronchiseptica. Since previously infected animals have been shown to resist re-infection by B...

More Information

Publications96

  1. Brockmeier S. Prior infection with Bordetella bronchiseptica increases nasal colonization by Haemophilus parasuis in swine. Vet Microbiol. 2004;99:75-8 pubmed
    The objective of this study was to determine whether Bordetella bronchiseptica would predispose to colonization or disease with Haemophilus parasuis. Three experiments were completed...
  2. Preston A, Petersen B, Duus J, Kubler Kielb J, Ben Menachem G, Li J, et al. Complete structures of Bordetella bronchiseptica and Bordetella parapertussis lipopolysaccharides. J Biol Chem. 2006;281:18135-44 pubmed
    The structures of the lipopolysaccharide (LPS) core and O antigen of Bordetella bronchiseptica and Bordetella parapertussis are known, but how these two regions are linked to each other had not been determined...
  3. Mishra M, Parise G, Jackson K, Wozniak D, Deora R. The BvgAS signal transduction system regulates biofilm development in Bordetella. J Bacteriol. 2005;187:1474-84 pubmed
    ..Finally, we discuss the significance of the biofilm lifestyle mode as a potential contributor to persistent infections...
  4. Edwards J, Groathouse N, Boitano S. Bordetella bronchiseptica adherence to cilia is mediated by multiple adhesin factors and blocked by surfactant protein A. Infect Immun. 2005;73:3618-26 pubmed
    In the virulent state (Bvg+), Bordetella bronchiseptica expresses adhesins and toxins that mediate adherence to the upper airway epithelium, an essential early step in pathogenesis...
  5. Brockmeier S, Lager K. Experimental airborne transmission of porcine reproductive and respiratory syndrome virus and Bordetella bronchiseptica. Vet Microbiol. 2002;89:267-75 pubmed
    Experiments were designed to determine if porcine reproductive and respiratory syndrome virus (PRRSV) or Bordetella bronchiseptica could be transmitted through indirect airborne contact. Three principal pigs were infected with PRRSV, B...
  6. Vinogradov E, Peppler M, Perry M. The structure of the nonreducing terminal groups in the O-specific polysaccharides from two strains of Bordetella bronchiseptica. Eur J Biochem. 2000;267:7230-7 pubmed
    The structures of the polysaccharide chains of the LPS from Bordetella bronchiseptica strains 110H and Bp512 were analysed by NMR spectroscopy and mass spectrometry...
  7. Liu M, Deora R, Doulatov S, Gingery M, Eiserling F, Preston A, et al. Reverse transcriptase-mediated tropism switching in Bordetella bacteriophage. Science. 2002;295:2091-4 pubmed
    ..This cassette-based mechanism is capable of providing a vast repertoire of potential ligand-receptor interactions. ..
  8. Mann P, Goebel E, Barbarich J, Pilione M, Kennett M, Harvill E. Use of a genetically defined double mutant strain of Bordetella bronchiseptica lacking adenylate cyclase and type III secretion as a live vaccine. Infect Immun. 2007;75:3665-72 pubmed
    ..b>Bordetella bronchiseptica is a gram-negative respiratory pathogen that is endemic in many nonhuman mammalian populations and ..
  9. Wallet F, Perez T, Armand S, Wallaert B, Courcol R. Pneumonia due to Bordetella bronchiseptica in a cystic fibrosis patient: 16S rRNA sequencing for diagnosis confirmation. J Clin Microbiol. 2002;40:2300-1 pubmed
    b>Bordetella bronchiseptica was identified as an unusual etiologic agent of pulmonary recurrent exacerbations and pneumonia in a cystic fibrosis (CF) patient by utilizing a 16S rRNA molecular kit in our hospital's clinical laboratory...
  10. Magyar T, Donkó T, Kovacs F. Atrophic rhinitis vaccine composition triggers different serological profiles that do not correlate with protection. Acta Vet Hung. 2008;56:27-40 pubmed publisher
    Atrophic rhinitis (AR) is a widespread and economically important disease of swine caused by Bordetella bronchiseptica and Pasteurella multocida. It can be controlled by vaccination...
  11. Mattoo S, Miller J, Cotter P. Role of Bordetella bronchiseptica fimbriae in tracheal colonization and development of a humoral immune response. Infect Immun. 2000;68:2024-33 pubmed
    ..b>Bordetella bronchiseptica has four known fimbrial genes: fim2, fim3, fimX, and fimA...
  12. Kuwae A, Ohishi M, Watanabe M, Nagai M, Abe A. BopB is a type III secreted protein in Bordetella bronchiseptica and is required for cytotoxicity against cultured mammalian cells. Cell Microbiol. 2003;5:973-83 pubmed
    The cytotoxicity of Bordetella bronchiseptica to infected cells is known to be dependent on a B. bronchiseptica type III secretion system...
  13. Loving C, Brockmeier S, Vincent A, Palmer M, Sacco R, Nicholson T. Influenza virus coinfection with Bordetella bronchiseptica enhances bacterial colonization and host responses exacerbating pulmonary lesions. Microb Pathog. 2010;49:237-45 pubmed publisher
    ..Overall, Flu infection increased Bb colonization and enhanced production of proinflammatory mediators that likely contribute to exacerbated pulmonary lesions. ..
  14. Widney D, Hu Y, Foreman Wykert A, Bui K, Nguyen T, Lu B, et al. CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung. Infect Immun. 2005;73:485-93 pubmed
    Intranasal inoculation of mice with Bordetella bronchiseptica produces a transient pneumonia that is cleared over several weeks in a process known to require both neutrophils and lymphocytes...
  15. Stockbauer K, Fuchslocher B, Miller J, Cotter P. Identification and characterization of BipA, a Bordetella Bvg-intermediate phase protein. Mol Microbiol. 2001;39:65-78 pubmed
    ..Recently, we identified a phenotypic phase of Bordetella bronchiseptica that displays reduced virulence in a rat model of respiratory infection concomitant with increased ..
  16. Beall B, Hoenes T. An iron-regulated outer-membrane protein specific to Bordetella bronchiseptica and homologous to ferric siderophore receptors. Microbiology. 1997;143 ( Pt 1):135-45 pubmed
    The bfrA (Bordetella bronchiseptica ferric iron repressed outer-membrane protein) gene was cloned from Bordetella bronchiseptica by screening a library of TnphoA insertion mutants for iron-repressed fusions to phoA...
  17. Kadlec K, Kehrenberg C, Schwarz S. Efflux-mediated resistance to florfenicol and/or chloramphenicol in Bordetella bronchiseptica: identification of a novel chloramphenicol exporter. J Antimicrob Chemother. 2007;59:191-6 pubmed
    Twenty florfenicol- and/or chloramphenicol-resistant Bordetella bronchiseptica isolates of porcine and feline origin were investigated for the presence of floR and cml genes and their location on plasmids. The B...
  18. Skinner J, Reissinger A, Shen H, Yuk M. Bordetella type III secretion and adenylate cyclase toxin synergize to drive dendritic cells into a semimature state. J Immunol. 2004;173:1934-40 pubmed
    b>Bordetella bronchiseptica establishes persistent infection of the murine respiratory tract...
  19. Gueirard P, Bassinet L, Bonne I, Prevost M, Guiso N. Ultrastructural analysis of the interactions between Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica and human tracheal epithelial cells. Microb Pathog. 2005;38:41-6 pubmed
    Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are respiratory pathogens that colonize the respiratory tract of their host after adhesion to the respiratory epithelium...
  20. Pósa R, Donkó T, Bogner P, Kovacs M, Repa I, Magyar T. Interaction of Bordetella bronchiseptica, Pasteurella multocida, and fumonisin B1 in the porcine respiratory tract as studied by computed tomography. Can J Vet Res. 2011;75:176-82 pubmed
    The interaction of Bordetella bronchiseptica, toxigenic Pasteurella multocida serotype D, and the mycotoxin fumonisin B(1) (FB(1)) was studied...
  21. Zhao Z, Wang C, Xue Y, Tang X, Wu B, Cheng X, et al. The occurrence of Bordetella bronchiseptica in pigs with clinical respiratory disease. Vet J. 2011;188:337-40 pubmed publisher
    Between January 2003 and September 2008, 652 Bordetella bronchiseptica isolates were cultured from 3506 lung samples collected from pigs with respiratory disease. Over the 6-year period, the average isolation rate was 18.6%, making B...
  22. Mann P, Kennett M, Harvill E. Toll-like receptor 4 is critical to innate host defense in a murine model of bordetellosis. J Infect Dis. 2004;189:833-6 pubmed
    ..TLR4-deficient mice rapidly succumb following inoculation with as few as 1000 organisms, indicating that TLR4 is critical to innate host defense against bordetellosis...
  23. Mazar J, Cotter P. Topology and maturation of filamentous haemagglutinin suggest a new model for two-partner secretion. Mol Microbiol. 2006;62:641-54 pubmed
    ..This model provides an explanation for the energetics of export of globular protein domains across membranes in the absence of ATP and it suggests a new mechanism for the control of protein folding. ..
  24. Brockmeier S, Register K, Magyar T, Lax A, Pullinger G, Kunkle R. Role of the dermonecrotic toxin of Bordetella bronchiseptica in the pathogenesis of respiratory disease in swine. Infect Immun. 2002;70:481-90 pubmed
    b>Bordetella bronchiseptica is one of the etiologic agents causing atrophic rhinitis and pneumonia in swine...
  25. Kirimanjeswara G, Mann P, Harvill E. Role of antibodies in immunity to Bordetella infections. Infect Immun. 2003;71:1719-24 pubmed
  26. Thakar J, Saadatpour Moghaddam A, Harvill E, Albert R. Constraint-based network model of pathogen-immune system interactions. J R Soc Interface. 2009;6:599-612 pubmed publisher
    Pathogenic bacteria such as Bordetella bronchiseptica modulate host immune responses to enable their establishment and persistence; however, the immune response is generally successful in clearing these bacteria...
  27. Sloan G, Love C, Sukumar N, Mishra M, Deora R. The Bordetella Bps polysaccharide is critical for biofilm development in the mouse respiratory tract. J Bacteriol. 2007;189:8270-6 pubmed
    Bordetellae are respiratory pathogens that infect both humans and animals. Bordetella bronchiseptica establishes asymptomatic and long-term to life-long infections of animal nasopharynges...
  28. Jiang H, Park I, Shin N, Yoo H, Akaike T, Cho C. Controlled release of Bordetella bronchiseptica dermonecrotoxin (BBD) vaccine from BBD-loaded chitosan microspheres in vitro. Arch Pharm Res. 2004;27:346-50 pubmed
    ..b>Bordetella Bronchiseptica Dermonecrotoxin (BBD) as a major virulence factor of a causative agent of atrophic rhinitis (AR) was ..
  29. Pilione M, Pishko E, Preston A, Maskell D, Harvill E. pagP is required for resistance to antibody-mediated complement lysis during Bordetella bronchiseptica respiratory infection. Infect Immun. 2004;72:2837-42 pubmed
    ..b>Bordetella bronchiseptica is a gram-negative respiratory pathogen that naturally infects mice and persists in the lower ..
  30. Vergara Irigaray N, Chávarri Martínez A, Rodríguez Cuesta J, Miller J, Cotter P, Martinez de Tejada G. Evaluation of the role of the Bvg intermediate phase in Bordetella pertussis during experimental respiratory infection. Infect Immun. 2005;73:748-60 pubmed
    ..Finally, even though B. pertussis expresses in vitro the Bvg(i) phase at the human nasal temperature, anti-BipA antibodies were undetectable in a large collection of sera from pertussis patients...
  31. Lehar C, Jayappa H, Erskine J, Brown A, Sweeney D, Wassmoen T. Demonstration of 1-year duration of immunity for attenuated Bordetella bronchiseptica vaccines in dogs. Vet Ther. 2008;9:257-62 pubmed
    Three groups of healthy dogs with low antibody titers to Bordetella bronchiseptica (Bb), canine parainfluenza virus (CPI), and canine adenovirus type 2 (CAV-2) were used in this study...
  32. Stubs D, Fuchs T, Schneider B, Bosserhoff A, Gross R. Identification and regulation of cold-inducible factors of Bordetella bronchiseptica. Microbiology. 2005;151:1895-909 pubmed
    ..b>Bordetella bronchiseptica encodes five CSPs (named CspA to CspE) with significant amino acid homology to CspA of Escherichia coli...
  33. Irie Y, O Toole G, Yuk M. Pseudomonas aeruginosa rhamnolipids disperse Bordetella bronchiseptica biofilms. FEMS Microbiol Lett. 2005;250:237-43 pubmed
    We have previously reported that the respiratory pathogen Bordetella bronchiseptica can form biofilms in vitro. In this report, we demonstrate the disruption of B...
  34. Spears P, Temple L, Miyamoto D, Maskell D, Orndorff P. Unexpected similarities between Bordetella avium and other pathogenic Bordetellae. Infect Immun. 2003;71:2591-7 pubmed
  35. Burns V, Pishko E, Preston A, Maskell D, Harvill E. Role of Bordetella O antigen in respiratory tract infection. Infect Immun. 2003;71:86-94 pubmed
    ..Genes of the wbm locus are required for the assembly of O antigen on the animal pathogen Bordetella bronchiseptica and the human pathogen B. parapertussis. However, the important human pathogen B...
  36. Magyar T, King V, Kovacs F. Evaluation of vaccines for atrophic rhinitis--a comparison of three challenge models. Vaccine. 2002;20:1797-802 pubmed
    ..three challenge models for the assessment of atrophic rhinitis (AR) vaccines: combined infection with Bordetella bronchiseptica (Bb) and Pasteurella multocida (Pm); application of acetic acid (AA) to the nasal mucosa followed by Pm ..
  37. Jacob Dubuisson F, Kehoe B, Willery E, Reveneau N, Locht C, Relman D. Molecular characterization of Bordetella bronchiseptica filamentous haemagglutinin and its secretion machinery. Microbiology. 2000;146 ( Pt 5):1211-21 pubmed
    Two closely related pathogens, Bordetella pertussis and Bordetella bronchiseptica, share a number of virulence factors. Filamentous haemagglutinin (FHA) is widely regarded as the dominant adhesin of B...
  38. Buboltz A, Nicholson T, Parette M, Hester S, Parkhill J, Harvill E. Replacement of adenylate cyclase toxin in a lineage of Bordetella bronchiseptica. J Bacteriol. 2008;190:5502-11 pubmed publisher
    b>Bordetella bronchiseptica is a gram-negative respiratory pathogen that infects a wide range of hosts and causes a diverse spectrum of disease...
  39. Yuk M, Harvill E, Miller J. The BvgAS virulence control system regulates type III secretion in Bordetella bronchiseptica. Mol Microbiol. 1998;28:945-59 pubmed
    ..arbitrary-primed polymerase chain reaction (PCR), we identified a gene expressed in the Bvg+ phase of Bordetella bronchiseptica that shows a high degree of sequence similarity to a locus involved in providing energy for type III ..
  40. Register K, Boisvert A, Ackermann M. Use of ribotyping to distinguish Bordetella bronchiseptica isolates. Int J Syst Bacteriol. 1997;47:678-83 pubmed
    A total of 113 Bordetella bronchiseptica strains, isolated from 11 different host species worldwide, were characterized by ribotyping with restriction enzyme PvuII...
  41. Hausman S, Cherry J, Heininger U, Wirsing von König C, Burns D. Analysis of proteins encoded by the ptx and ptl genes of Bordetella bronchiseptica and Bordetella parapertussis. Infect Immun. 1996;64:4020-6 pubmed
    ..pertussis is the only bacteria] species which is known to produce pertussis toxin (PT); however, both Bordetella bronchiseptica and Bordetella parapertussis contain regions homologous to the ptx genes of B...
  42. Menozzi F, Gantiez C, Locht C. Identification and purification of transferrin- and lactoferrin-binding proteins of Bordetella pertussis and Bordetella bronchiseptica. Infect Immun. 1991;59:3982-8 pubmed
    Bordetella pertussis and Bordetella bronchiseptica were both able to grow in iron-deficient medium when supplemented with iron-saturated human lactoferrin or transferrin but not with human apotransferrin...
  43. King J, Vinogradov E, Preston A, Li J, Maskell D. Post-assembly modification of Bordetella bronchiseptica O polysaccharide by a novel periplasmic enzyme encoded by wbmE. J Biol Chem. 2009;284:1474-83 pubmed publisher
    b>Bordetella bronchiseptica is a pathogen of humans and animals that colonizes the respiratory tract. It produces a lipopolysaccharide O antigen that contains a homopolymer of 2,3-dideoxy-2,3-diacetamido-L-galacturonic acid (L-GalNAc3NAcA)...
  44. Huebner E, Christman B, Dummer S, Tang Y, Goodman S. Hospital-acquired Bordetella bronchiseptica infection following hematopoietic stem cell transplantation. J Clin Microbiol. 2006;44:2581-3 pubmed
    ..53 and 112 days earlier and were being monitored at the same transplant center developed severe Bordetella bronchiseptica infections within 3 days of each other...
  45. Kang M, Kang S, Jiang H, Shin S, Lee D, Ahn J, et al. In vivo induction of mucosal immune responses by intranasal administration of chitosan microspheres containing Bordetella bronchiseptica DNT. Eur J Pharm Biopharm. 2006;63:215-20 pubmed
    In vitro immune-stimulating activities of Bordetella bronchiseptica dermonecrotoxin (BBD)-loaded in chitosan microspheres (CMs) were reported with a mouse alveolar macrophage cell line (RAW264.7)...
  46. Pilione M, Harvill E. The Bordetella bronchiseptica type III secretion system inhibits gamma interferon production that is required for efficient antibody-mediated bacterial clearance. Infect Immun. 2006;74:1043-9 pubmed
    ..Here, we report an immunomodulation involving the Bordetella bronchiseptica type III secretion system (TTSS) which contributes to bacterial survival in the lower respiratory tract ..
  47. Akerley B, Monack D, Falkow S, Miller J. The bvgAS locus negatively controls motility and synthesis of flagella in Bordetella bronchiseptica. J Bacteriol. 1992;174:980-90 pubmed
    ..We have identified a phenotype in Bordetella bronchiseptica that is negatively controlled by bvg...
  48. Mann P, Wolfe D, Latz E, Golenbock D, Preston A, Harvill E. Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection. Infect Immun. 2005;73:8144-52 pubmed
    ..Thus, it appears that in adapting to infect humans, B. pertussis and B. parapertussis independently modified their LPS to reduce TLR4-mediated responses, which may compensate for slower growth rates and facilitate host colonization...
  49. Dworkin M, Sullivan P, Buskin S, Harrington R, Olliffe J, MacArthur R, et al. Bordetella bronchiseptica infection in human immunodeficiency virus-infected patients. Clin Infect Dis. 1999;28:1095-9 pubmed
    b>Bordetella bronchiseptica is a pleomorphic gram-negative coccobacillus that commonly causes respiratory tract infections in dogs. We identified nine human immunodeficiency virus (HIV)-infected persons with culture-confirmed B...
  50. Buboltz A, Nicholson T, Karanikas A, Preston A, Harvill E. Evidence for horizontal gene transfer of two antigenically distinct O antigens in Bordetella bronchiseptica. Infect Immun. 2009;77:3249-57 pubmed publisher
    ..Here we show that two Bordetella bronchiseptica strains, RB50 and 1289, express two antigenically distinct O-antigen serotypes (O1 and O2, respectively)...
  51. Sacco R, Register K, Nordholm G. Restriction endonuclease analysis discriminates Bordetella bronchiseptica isolates. J Clin Microbiol. 2000;38:4387-93 pubmed
    One hundred ninety-five Bordetella bronchiseptica isolates from 12 different host species worldwide were characterized by restriction enzyme analysis (REA). These isolates had previously been categorized into 19 PvuII ribotypes...
  52. Pathak A, Creppage K, Werner J, Cattadori I. Immune regulation of a chronic bacteria infection and consequences for pathogen transmission. BMC Microbiol. 2010;10:226 pubmed publisher
    ..Despite the interest in this area of study, and the development of theoretical work on the immuno-epidemiology of infections, little is known about the immunological processes that influence pathogen shedding patterns...
  53. Iemura R, Tsukatani R, Micallef M, Taneno A. Simultaneous analysis of the nasal shedding kinetics of field and vaccine strains of Bordetella bronchiseptica. Vet Rec. 2009;165:747-51 pubmed
    ..of four two-week-old puppies were administered serial dilutions of an intranasal vaccine containing live Bordetella bronchiseptica and canine parainfluenza virus vaccine and housed individually in isolator cages...
  54. Vinogradov E, King J, Pathak A, Harvill E, Preston A. Antigenic Variation among Bordetella: Bordetella bronchiseptica strain MO149 expresses a novel o chain that is poorly immunogenic. J Biol Chem. 2010;285:26869-77 pubmed publisher
    The O chain polysaccharide (O PS) of Bordetella bronchiseptica and Bordetella parapertussis lipopolysaccharide is a homopolymer of 2,3-diacetamido-2,3-dideoxygalacturonic acid (GalNAc3NAcA) in which some of the sugars are present as ..
  55. Belen O, Campos J, Cogen P, Jantausch B. Postsurgical meningitis caused by Bordetella bronchiseptica. Pediatr Infect Dis J. 2003;22:380-1 pubmed
  56. Won K, Ha G, Kim J, Kang H, Tak W, Lee J. Relapsing peritonitis caused by Bordetella bronchiseptica in continuous ambulatory peritoneal dialysis patient: a case report. J Korean Med Sci. 2009;24 Suppl:S215-8 pubmed publisher
    ..Finally, the indwelling CAPD catheter was removed and the patient was started on hemodialysis. This is the first report of a B. bronchiseptica human infection in the Korean literature...
  57. Horiguchi Y, Inoue N, Masuda M, Kashimoto T, Katahira J, Sugimoto N, et al. Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho. Proc Natl Acad Sci U S A. 1997;94:11623-6 pubmed
    ..These results indicate that the toxin catalyzes deamidation of Gln-63 of Rho and renders it constitutively active, leading to formation of actin stress fibers...
  58. Irie Y, Yuk M. In vivo colonization profile study of Bordetella bronchiseptica in the nasal cavity. FEMS Microbiol Lett. 2007;275:191-8 pubmed
    b>Bordetella bronchiseptica chronically infects a wide range of mammals, and resides primarily in the nasal cavity of the infected host...
  59. Medhekar B, Shrivastava R, Mattoo S, Gingery M, Miller J. Bordetella Bsp22 forms a filamentous type III secretion system tip complex and is immunoprotective in vitro and in vivo. Mol Microbiol. 2009;71:492-504 pubmed publisher
    ..that Bsp22, the most abundantly secreted substrate of the Bordetella T3SS, self-polymerizes to form the Bordetella bronchiseptica tip complex...
  60. Parkhill J, Sebaihia M, Preston A, Murphy L, Thomson N, Harris D, et al. Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet. 2003;35:32-40 pubmed
    Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative beta-proteobacteria that colonize the respiratory tracts of mammals. B...
  61. Cummings C, Bootsma H, Relman D, Miller J. Species- and strain-specific control of a complex, flexible regulon by Bordetella BvgAS. J Bacteriol. 2006;188:1775-85 pubmed
    ..pertussis. We propose the concept of a "flexible regulon." This flexible regulon may prove to be important for pathogen evolution and the diversification of host range specificity...
  62. Kozak N, Mattoo S, Foreman Wykert A, Whitelegge J, Miller J. Interactions between partner switcher orthologs BtrW and BtrV regulate type III secretion in Bordetella. J Bacteriol. 2005;187:5665-76 pubmed
  63. Chalker V, Toomey C, Opperman S, Brooks H, Ibuoye M, Brownlie J, et al. Respiratory disease in kennelled dogs: serological responses to Bordetella bronchiseptica lipopolysaccharide do not correlate with bacterial isolation or clinical respiratory symptoms. Clin Diagn Lab Immunol. 2003;10:352-6 pubmed
    The role of Bordetella bronchiseptica in a natural outbreak of canine infectious respiratory disease was investigated both by culture and serological analysis. B...
  64. Stevenson A, Roberts M. Use of Bordetella bronchiseptica and Bordetella pertussis as live vaccines and vectors for heterologous antigens. FEMS Immunol Med Microbiol. 2003;37:121-8 pubmed
    Bordetella pertussis and Bordetella bronchiseptica are respiratory pathogens of humans and animals respectively. Unlike many bacteria, they are able to efficiently colonise healthy ciliated respiratory mucosa...
  65. West N, Jungnitz H, Fitter J, McArthur J, Guzm n C, Walker M. Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence. Infect Immun. 2000;68:4673-80 pubmed
    The phosphoglucomutase (PGM)-encoding gene of Bordetella bronchiseptica is required for lipopolysaccharide (LPS) biosynthesis. An insertion mutant of the wild-type B...
  66. Conover M, Mishra M, Deora R. Extracellular DNA is essential for maintaining Bordetella biofilm integrity on abiotic surfaces and in the upper respiratory tract of mice. PLoS ONE. 2011;6:e16861 pubmed publisher
    ..shown that by adopting a biofilm mode of existence in vivo, the gram negative bacterial pathogens Bordetella bronchiseptica and Bordetella pertussis are able to efficiently colonize and persist in the mammalian respiratory tract...
  67. Kuwae A, Matsuzawa T, Ishikawa N, Abe H, Nonaka T, Fukuda H, et al. BopC is a novel type III effector secreted by Bordetella bronchiseptica and has a critical role in type III-dependent necrotic cell death. J Biol Chem. 2006;281:6589-600 pubmed
    In Bordetella bronchiseptica, the functional type III secretion system (TTSS) is required for the induction of necrotic cell death in infected mammalian cells...
  68. Buboltz A, Nicholson T, Weyrich L, Harvill E. Role of the type III secretion system in a hypervirulent lineage of Bordetella bronchiseptica. Infect Immun. 2009;77:3969-77 pubmed publisher
    ..We use a combination of approaches to determine which factors contribute to the increased virulence of a Bordetella bronchiseptica lineage. A strain isolated from a host with B...
  69. Kowalczyk A, Pomorska Mól M, Kwit K, Pejsak Z, Rachubik J, Markowska Daniel I. Cytokine and chemokine mRNA expression profiles in BALF cells isolated from pigs single infected or co-infected with swine influenza virus and Bordetella bronchiseptica. Vet Microbiol. 2014;170:206-12 pubmed publisher
    ..animal experimental model for several respiratory pathogens, including Swine Influenza Virus (SIV) and Bordetella bronchiseptica (Bbr)...
  70. Li J, Fairweather N, Novotny P, Dougan G, Charles I. Cloning, nucleotide sequence and heterologous expression of the protective outer-membrane protein P.68 pertactin from Bordetella bronchiseptica. J Gen Microbiol. 1992;138 Pt 8:1697-705 pubmed publisher
    The prn gene encoding the 68 kDa protective outer-membrane protein of Bordetella bronchiseptica (P.68 pertactin) was cloned, sequenced and expressed in Escherichia coli...
  71. Pradel E, Locht C. Expression of the putative siderophore receptor gene bfrZ is controlled by the extracytoplasmic-function sigma factor BupI in Bordetella bronchiseptica. J Bacteriol. 2001;183:2910-7 pubmed
    A new gene from Bordetella bronchiseptica, bfrZ encoding a putative siderophore receptor, was identified in a Fur-repressor titration assay. A bfrZ null mutant was constructed by allelic exchange...
  72. Kang M, Jiang H, Kang S, Guo D, Lee D, Cho C, et al. Pluronic F127 enhances the effect as an adjuvant of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxin. Vaccine. 2007;25:4602-10 pubmed
    ..The Bordetella bronchiseptica multiple antigens containing dermonecrotoxin (BBD), a virulent factor leading to atrophic rhinitis (AR) ..
  73. Zimna K, Medina E, Jungnitz H, Guzman C. Role played by the response regulator Ris in Bordetella bronchiseptica resistance to macrophage killing. FEMS Microbiol Lett. 2001;201:177-80 pubmed
    Previous studies suggested that the persistence in eukaryotic cells of a Bordetella bronchiseptica mutant carrying an insertion in the locus encoding the response regulator RisAS is impaired...
  74. Carbone M, Pennisi M, Masucci M, De Sarro A, Giannone M, Fera M. Activity and postantibiotic effect of marbofloxacin, enrofloxacin, difloxacin and ciprofloxacin against feline Bordetella bronchiseptica isolates. Vet Microbiol. 2001;81:79-84 pubmed
    ..enrofloxacin, difloxacin and ciprofloxacin were evaluated in vitro against 43 feline-source Bordetella bronchiseptica strains. All strains tested were susceptible to marbofloxacin and enrofloxacin (MIC90 0...
  75. Horiguchi Y, Okada T, Sugimoto N, Morikawa Y, Katahira J, Matsuda M. Effects of Bordetella bronchiseptica dermonecrotizing toxin on bone formation in calvaria of neonatal rats. FEMS Immunol Med Microbiol. 1995;12:29-32 pubmed
    The effects of Bordetella bronchiseptica dermonecrotizing toxin on bone formation were investigated using a purified toxin preparation. Single injection of 4...
  76. McMillan D, Mau M, Walker M. Characterisation of the urease gene cluster in Bordetella bronchiseptica. Gene. 1998;208:243-51 pubmed
    b>Bordetella bronchiseptica is a common ureolytic mammalian respiratory pathogen. The urease operon of this organism is encoded within an 8...
  77. Preston A, Allen A, Cadisch J, Thomas R, Stevens K, Churcher C, et al. Genetic basis for lipopolysaccharide O-antigen biosynthesis in bordetellae. Infect Immun. 1999;67:3763-7 pubmed
    b>Bordetella bronchiseptica and Bordetella parapertussis express a surface polysaccharide, attached to a lipopolysaccharide, which has been called O antigen. This structure is absent from Bordetella pertussis...
  78. Kirimanjeswara G, Mann P, Pilione M, Kennett M, Harvill E. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol. 2005;175:7504-11 pubmed
    ..Using the mouse respiratory pathogen Bordetella bronchiseptica, we examined the mechanisms of Ab-mediated clearance of bacteria from the respiratory tract...
  79. Kislyuk A, Katz L, Agrawal S, Hagen M, Conley A, Jayaraman P, et al. A computational genomics pipeline for prokaryotic sequencing projects. Bioinformatics. 2010;26:1819-26 pubmed publisher
    ..The resulting requirement to invest significant resources into custom informatics support for genome sequencing projects remains a major impediment to the accessibility of high-throughput sequence data...
  80. Pishko E, Kirimanjeswara G, Pilione M, Gopinathan L, Kennett M, Harvill E. Antibody-mediated bacterial clearance from the lower respiratory tract of mice requires complement component C3. Eur J Immunol. 2004;34:184-93 pubmed
    ..bacterial infection, we used mice genetically deficient in complement components and the murine pathogen Bordetella bronchiseptica. Complement component C3 was not required for the control of bacterial infection or for the generation ..
  81. Mazumder S, Cleveland K. Bordetella bronchiseptica bacteremia in a patient with AIDS. South Med J. 2010;103:934-5 pubmed publisher
    b>Bordetella bronchiseptica bacteremia is often associated with various infection in animals. The majority of B bronchiseptica infections reported in humans are cases of pneumonia...
  82. Winstanley C, Shina A, Dawson S, Gaskell R, Hart C. Variation in Bordetella bronchiseptica flaA does not correlate with typing by macro-restriction analysis by pulsed-field gel electrophoresis. J Med Microbiol. 2001;50:255-60 pubmed publisher
    ..based on PCR-RFLP analysis of the flagellin gene (flaA) was applied to 30 mainly feline isolates of Bordetella bronchiseptica. These isolates were separated into three PCR-RFLP groups with the restriction endonucleases HaeIII, ..
  83. Nogawa H, Kuwae A, Matsuzawa T, Abe A. The type III secreted protein BopD in Bordetella bronchiseptica is complexed with BopB for pore formation on the host plasma membrane. J Bacteriol. 2004;186:3806-13 pubmed
    The cytotoxicity of Bordetella bronchiseptica to infected cells is known to be dependent on a B. bronchiseptica type III secretion system...
  84. Skinner J, Pilione M, Shen H, Harvill E, Yuk M. Bordetella type III secretion modulates dendritic cell migration resulting in immunosuppression and bacterial persistence. J Immunol. 2005;175:4647-52 pubmed
    ..b>Bordetella bronchiseptica uses a type III secretion system (TTSS) to persist in the lower respiratory tract of mice...
  85. Yevsa T, Ebensen T, Fuchs B, Zygmunt B, Libanova R, Gross R, et al. Development and characterization of attenuated metabolic mutants of Bordetella bronchiseptica for applications in vaccinology. Environ Microbiol. 2013;15:64-76 pubmed publisher
    b>Bordetella bronchiseptica is an important pathogen causing a number of veterinary respiratory syndromes in agriculturally important and food-producing confinement-reared animals, resulting in great economic losses annually amounting to ..
  86. Sukumar N, Love C, Conover M, Kock N, Dubey P, Deora R. Active and passive immunizations with Bordetella colonization factor A protect mice against respiratory challenge with Bordetella bronchiseptica. Infect Immun. 2009;77:885-95 pubmed publisher
    ..properties of BcfA prompted us to examine its utility in inducing a protective immune response against Bordetella bronchiseptica in a mouse model of intranasal infection...
  87. Gueirard P, Ave P, Balazuc A, Thiberge S, Huerre M, Milon G, et al. Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract. Infect Immun. 2003;71:4137-43 pubmed
    Early after the intranasal instillation of Bordetella bronchiseptica into mice, not only are mature dendritic leukocytes recovered from lung parenchyma and bronchoalveolar lavage fluid but their numbers are also increased in the ..