yersinia pseudotuberculosis

Summary

Summary: A human and animal pathogen causing mesenteric lymphadenitis, diarrhea, and bacteremia.

Top Publications

  1. Zhang Y, Bliska J. YopJ-promoted cytotoxicity and systemic colonization are associated with high levels of murine interleukin-18, gamma interferon, and neutrophils in a live vaccine model of Yersinia pseudotuberculosis infection. Infect Immun. 2010;78:2329-41 pubmed publisher
    ..pseudotuberculosis and potentially enhancing adaptive immunity to a live vaccine. ..
  2. Carlsson K, Liu J, Edqvist P, Francis M. Influence of the Cpx extracytoplasmic-stress-responsive pathway on Yersinia sp.-eukaryotic cell contact. Infect Immun. 2007;75:4386-99 pubmed
    ..This is true of the Yersinia pseudotuberculosis Ysc-Yop type III secretion system...
  3. Wang X, Zhou D, Qin L, Dai E, Zhang J, Han Y, et al. Genomic comparison of Yersinia pestis and Yersinia pseudotuberculosis by combination of suppression subtractive hybridization and DNA microarray. Arch Microbiol. 2006;186:151-9 pubmed
    In order to further figure out the genetic differences between Yersinia pestis and Yersinia pseudotuberculosis, and to provide novel insights into the evolution of Y. pestis, we compared the genomes of Y...
  4. Amer A, Ahlund M, Bröms J, Forsberg A, Francis M. Impact of the N-terminal secretor domain on YopD translocator function in Yersinia pseudotuberculosis type III secretion. J Bacteriol. 2011;193:6683-700 pubmed publisher
    ..molecular constraints influence translocator secretion, we scrutinized this region within YopD from Yersinia pseudotuberculosis. Mutations in the 5' end of yopD that resulted in specific disruption of the mRNA sequence did not ..
  5. Kondakova A, Shaikhutdinova R, Ivanov S, Dentovskaya S, Shashkov A, Anisimov A, et al. Revision of the O-polysaccharide structure of Yersinia pseudotuberculosis O:1b. Carbohydr Res. 2009;344:2421-3 pubmed publisher
    The O-polysaccharide of Yersinia pseudotuberculosis O:1b was reinvestigated using (1)H and (13)C NMR spectroscopy, and the anomeric configuration of the mannose residue at the branching point was revised...
  6. Viboud G, Mejia E, Bliska J. Comparison of YopE and YopT activities in counteracting host signalling responses to Yersinia pseudotuberculosis infection. Cell Microbiol. 2006;8:1504-15 pubmed
    ..are functionally redundant by dissecting the contribution of these two effectors to the pathogenesis of Yersinia pseudotuberculosis in a mouse infection and tissue culture model...
  7. Bröms J, Sundin C, Francis M, Forsberg A. Comparative analysis of type III effector translocation by Yersinia pseudotuberculosis expressing native LcrV or PcrV from Pseudomonas aeruginosa. J Infect Dis. 2003;188:239-49 pubmed
    ..Thus, a PcrV complex with native P. aeruginosa translocon components is required to form fully functional pores for complete complementation of effector translocation in Yersinia. ..
  8. McPhee J, Mena P, Zhang Y, Bliska J. Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM. Infect Immun. 2012;80:2519-27 pubmed publisher
    ..levels of the immunosuppressive cytokine interleukin-10 (IL-10) in sera of C57BL/6J mice infected with Yersinia pseudotuberculosis. To determine if IL-10 production is important for the virulence function of YopM, C57BL/6J or congenic ..
  9. Ch ng S, Octavia S, Xia Q, Duong A, Tanaka M, Fukushima H, et al. Population structure and evolution of pathogenicity of Yersinia pseudotuberculosis. Appl Environ Microbiol. 2011;77:768-75 pubmed publisher
    b>Yersinia pseudotuberculosis is an enteric human pathogen but is widespread in the environment...

More Information

Publications99

  1. Chain P, Carniel E, Larimer F, Lamerdin J, Stoutland P, Regala W, et al. Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis. Proc Natl Acad Sci U S A. 2004;101:13826-31 pubmed
    ..causative agent of plague, is a highly uniform clone that diverged recently from the enteric pathogen Yersinia pseudotuberculosis. Despite their close genetic relationship, they differ radically in their pathogenicity and ..
  2. Derbise A, Lesic B, Dacheux D, Ghigo J, Carniel E. A rapid and simple method for inactivating chromosomal genes in Yersinia. FEMS Immunol Med Microbiol. 2003;38:113-6 pubmed
    ..Using this method, three chromosomal loci were successfully disrupted in Yersinia pseudotuberculosis. The use of this technique allows rapid and efficient large-scale mutagenesis of Yersinia target ..
  3. Wiley D, Shrestha N, Yang J, Atis N, Dayton K, Schesser K. The activities of the Yersinia protein kinase A (YpkA) and outer protein J (YopJ) virulence factors converge on an eIF2alpha kinase. J Biol Chem. 2009;284:24744-53 pubmed publisher
  4. Crimmins G, Mohammadi S, Green E, Bergman M, Isberg R, Mecsas J. Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes. PLoS Pathog. 2012;8:e1002828 pubmed publisher
    ..Most notably, yields of viable plasmid-deficient Yersinia pseudotuberculosis (Yptb) are indistinguishable from wild-type Yptb within mesenteric lymph nodes...
  5. Taylor V, Titball R, Oyston P. Oral immunization with a dam mutant of Yersinia pseudotuberculosis protects against plague. Microbiology. 2005;151:1919-26 pubmed
    ..pathogens such as Salmonella enterica serovar Typhimurium and is a lethal mutation in others such as Yersinia pseudotuberculosis strain YPIII...
  6. Xu S, Peng Z, Cui B, Wang T, Song Y, Zhang L, et al. FliS modulates FlgM activity by acting as a non-canonical chaperone to control late flagellar gene expression, motility and biofilm formation in Yersinia pseudotuberculosis. Environ Microbiol. 2014;16:1090-104 pubmed publisher
    ..Based on the results obtained, we established for the first time the regulatory role of the flagellin chaperone FliS to fine-tune late flagellar assembly by modulating FlgM activity. ..
  7. Bröms J, Francis M, Forsberg A. Diminished LcrV secretion attenuates Yersinia pseudotuberculosis virulence. J Bacteriol. 2007;189:8417-29 pubmed
  8. Zhou D, Han Y, Song Y, Huang P, Yang R. Comparative and evolutionary genomics of Yersinia pestis. Microbes Infect. 2004;6:1226-34 pubmed
    ..Understanding the genomic variability and the adaptive evolution of Y. pestis from the genomic point of view will contribute greatly to plague detection, identification, control and prevention. ..
  9. Daniel C, Sebbane F, Poiret S, Goudercourt D, Dewulf J, Mullet C, et al. Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV. Vaccine. 2009;27:1141-4 pubmed publisher
    Herein, we sought to evaluate the potential of a recombinant Lactococcus lactis strain secreting the Yersinia pseudotuberculosis low-calcium response V (LcrV) antigen for mucosal vaccination against Yersinia infections...
  10. Ellison D, Lawrenz M, Miller V. Invasin and beyond: regulation of Yersinia virulence by RovA. Trends Microbiol. 2004;12:296-300 pubmed
    ..regulates expression of invasin, the major adhesion and invasion factor in Yersinia enterocolitica and Yersinia pseudotuberculosis. Disruption of rovA increases the LD(50) of the organism when inoculated using the oral route...
  11. Stubben C, Duffield M, Cooper I, Ford D, Gans J, Karlyshev A, et al. Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens. BMC Genomics. 2009;10:501 pubmed publisher
    ..Mutants of 13 of these candidates were successfully generated in Yersinia pseudotuberculosis and the potential role of the proteins in virulence was assayed in an animal model...
  12. Lilo S, Zheng Y, Bliska J. Caspase-1 activation in macrophages infected with Yersinia pestis KIM requires the type III secretion system effector YopJ. Infect Immun. 2008;76:3911-23 pubmed publisher
    ..Naïve murine macrophages were infected with a panel of different Yersinia pestis and Yersinia pseudotuberculosis strains to determine whether Yops of these species inhibit caspase-1 activation...
  13. Ryndak M, Chung H, London E, Bliska J. Role of predicted transmembrane domains for type III translocation, pore formation, and signaling by the Yersinia pseudotuberculosis YopB protein. Infect Immun. 2005;73:2433-43 pubmed
    ..b>Yersinia pseudotuberculosis strains expressing the mutant YopB proteins were used to infect macrophages or epithelial cells...
  14. Wong K, Isberg R. Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake. J Exp Med. 2003;198:603-14 pubmed
    Efficient entry of the bacterium Yersinia pseudotuberculosis into mammalian cells requires the binding of the bacterial invasin protein to beta1 integrin receptors and the activation of the small GTPase Rac1...
  15. Strong P, Hinchliffe S, Patrick H, Atkinson S, Champion O, Wren B. Identification and characterisation of a novel adhesin Ifp in Yersinia pseudotuberculosis. BMC Microbiol. 2011;11:85 pubmed publisher
    ..A new Y. pseudotuberculosis adhesin has been identified and characterised. This Ifp is a new member in the family of invasin/intimin outer membrane adhesins. ..
  16. Uliczka F, Pisano F, Kochut A, Opitz W, Herbst K, Stolz T, et al. Monitoring of gene expression in bacteria during infections using an adaptable set of bioluminescent, fluorescent and colorigenic fusion vectors. PLoS ONE. 2011;6:e20425 pubmed publisher
    ..To test our vector system, we analyzed and quantified expression of Yersinia pseudotuberculosis virulence genes under laboratory conditions, in association with cells and during the infection process. ..
  17. Fukushima H. Molecular epidemiology of Yersinia pseudotuberculosis. Adv Exp Med Biol. 2003;529:357-8 pubmed
  18. Ho D, Riva R, Kirjavainen V, Jarva H, Ginström E, Blom A, et al. Functional recruitment of the human complement inhibitor C4BP to Yersinia pseudotuberculosis outer membrane protein Ail. J Immunol. 2012;188:4450-9 pubmed publisher
    ..These results indicate that Y. pseudotuberculosis Ail recruits C4BP in a functional manner, facilitating resistance to attack from complement. ..
  19. Aili M, Isaksson E, Carlsson S, Wolf Watz H, Rosqvist R, Francis M. Regulation of Yersinia Yop-effector delivery by translocated YopE. Int J Med Microbiol. 2008;298:183-92 pubmed
    The bacterial pathogen Yersinia pseudotuberculosis uses a type III secretion (T3S) system to translocate Yop effectors into eukaryotic cells...
  20. Martínez P, Fredriksson Ahomaa M, Pallotti A, Rosmini R, Houf K, Korkeala H. Variation in the prevalence of enteropathogenic Yersinia in slaughter pigs from Belgium, Italy, and Spain. Foodborne Pathog Dis. 2011;8:445-50 pubmed publisher
    ..Isolation of Yersinia enterocolitica and Yersinia pseudotuberculosis was done by selective enrichment and by cold enrichment for 7 and 14 days. Pathogenic Y...
  21. Hares M, Hinchliffe S, Strong P, Eleftherianos I, Dowling A, Ffrench Constant R, et al. The Yersinia pseudotuberculosis and Yersinia pestis toxin complex is active against cultured mammalian cells. Microbiology. 2008;154:3503-17 pubmed publisher
    ..Here we present work to suggest that Tc proteins in Yersinia pseudotuberculosis and Yersinia pestis are not insecticidal toxins but have evolved for mammalian pathogenicity...
  22. Heroven A, Böhme K, Dersch P. The Csr/Rsm system of Yersinia and related pathogens: a post-transcriptional strategy for managing virulence. RNA Biol. 2012;9:379-91 pubmed publisher
    ..review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens...
  23. Flamez C, Ricard I, Arafah S, Simonet M, Marceau M. Two-component system regulon plasticity in bacteria: a concept emerging from phenotypic analysis of Yersinia pseudotuberculosis response regulator mutants. Adv Exp Med Biol. 2007;603:145-55 pubmed
    ..PhoP-PhoQ and PmrA-PmrB studies to the most recent genome-scale preliminary analyses--in an attempt to highlight the contribution of 2CS regulon plasticity to the acquisition of some of Yersinia pseudotuberculosis' specific features.
  24. De Castro C, Skurnik M, Molinaro A, Holst O. Characterization of the specific O-polysaccharide structure and biosynthetic gene cluster of Yersinia pseudotuberculosis serotype O:15. Innate Immun. 2009;15:351-9 pubmed publisher
    b>Yersinia pseudotuberculosis serotyping scheme contains 21 serotypes based on the distribution of about 30 different O-factors within the species...
  25. Eliseikina M, Timchenko N, Bulgakov A, Magarlamov T, Petrova I. Influence of Yersinia pseudotuberculosis on the immunity of echinoderms. Adv Exp Med Biol. 2003;529:173-5 pubmed
  26. Lesic B, Carniel E. Horizontal transfer of the high-pathogenicity island of Yersinia pseudotuberculosis. J Bacteriol. 2005;187:3352-8 pubmed
    ..We demonstrate here that the HPI is indeed transferable from a donor to a recipient Yersinia pseudotuberculosis strain...
  27. Hsu L, Park J, Zhang K, Luo J, Maeda S, Kaufman R, et al. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004;428:341-5 pubmed
    ..The pro-apoptotic actions of PKR are mediated both through inhibition of protein synthesis and activation of interferon response factor 3. ..
  28. Zheng Y, Lilo S, Brodsky I, Zhang Y, Medzhitov R, Marcu K, et al. A Yersinia effector with enhanced inhibitory activity on the NF-?B pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog. 2011;7:e1002026 pubmed publisher
    ..This pro-inflammatory form of apoptosis may represent an early innate immune response to highly virulent pathogens such as Y. pestis KIM that have evolved an enhanced ability to inhibit host signaling pathways. ..
  29. Kiljunen S, Datta N, Dentovskaya S, Anisimov A, Knirel Y, Bengoechea J, et al. Identification of the lipopolysaccharide core of Yersinia pestis and Yersinia pseudotuberculosis as the receptor for bacteriophage ?A1122. J Bacteriol. 2011;193:4963-72 pubmed publisher
    ..pestis. ?A1122 infects Y. pestis grown both at 20 °C and at 37 °C. Wild-type Yersinia pseudotuberculosis strains are also infected but only when grown at 37 °C. Since Y...
  30. Dahlgren M, Kauppi A, Olsson I, Linusson A, Elofsson M. Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides--potent inhibitors of type III secretion in Yersinia. J Med Chem. 2007;50:6177-88 pubmed
    ..A PLS discriminant analysis (PLS-DA) model was derived using the same descriptor set as that for the Hi-PLS model. Both models were validated with an external test set...
  31. Fredriksson Ahomaa M, Wacheck S, Bonke R, Stephan R. Different enteropathogenic Yersinia strains found in wild boars and domestic pigs. Foodborne Pathog Dis. 2011;8:733-7 pubmed publisher
    Yersinia enterocolitica and Yersinia pseudotuberculosis strains isolated from wild boars and fattening pigs were characterized and compared with each other. In wild boars, ail-positive Y...
  32. Reeves P, Pacinelli E, Wang L. O antigen gene clusters of Yersinia pseudotuberculosis. Adv Exp Med Biol. 2003;529:199-206 pubmed
  33. Hu Y, Wang Y, Ding L, Lu P, Atkinson S, Chen S. Positive regulation of flhDC expression by OmpR in Yersinia pseudotuberculosis. Microbiology. 2009;155:3622-31 pubmed publisher
    ..Here we report the positive regulation of flhDC expression by OmpR in Yersinia pseudotuberculosis. A sigma(70)-dependent promoter was identified by primer extension analysis and an active region with ..
  34. Branger C, Torres Escobar A, Sun W, Perry R, Fetherston J, Roland K, et al. Oral vaccination with LcrV from Yersinia pestis KIM delivered by live attenuated Salmonella enterica serovar Typhimurium elicits a protective immune response against challenge with Yersinia pseudotuberculosis and Yersinia enterocolitica. Vaccine. 2009;27:5363-70 pubmed publisher
    ..and protective efficacy elicited by these strains in mice against two other major species of Yersinia: Yersinia pseudotuberculosis and Yersinia enterocolitica...
  35. Schweer J, Kulkarni D, Kochut A, Pezoldt J, Pisano F, Pils M, et al. The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases. PLoS Pathog. 2013;9:e1003746 pubmed publisher
    Some isolates of Yersinia pseudotuberculosis produce the cytotoxic necrotizing factor (CNFY), but the functional consequences of this toxin for host-pathogen interactions during the infection are unknown...
  36. Touchman J, Wagner D, Hao J, Mastrian S, Shah M, Vogler A, et al. A North American Yersinia pestis draft genome sequence: SNPs and phylogenetic analysis. PLoS ONE. 2007;2:e220 pubmed
    ..Slowly-evolving but stable markers such as SNPs could be useful for this purpose, but are difficult to identify due to the monomorphic nature of North American isolates...
  37. Antonenka U, Nölting C, Heesemann J, Rakin A. Horizontal transfer of Yersinia high-pathogenicity island by the conjugative RP4 attB target-presenting shuttle plasmid. Mol Microbiol. 2005;57:727-34 pubmed
    ..Such 'trapping' of pathogenicity islands and subsequent shuffling to new hosts by a conjugative replicon carrying a suitable attB site could be applied to other functional integrative elements and explain wide dissemination of PAIs...
  38. Carlsson K, Liu J, Edqvist P, Francis M. Extracytoplasmic-stress-responsive pathways modulate type III secretion in Yersinia pseudotuberculosis. Infect Immun. 2007;75:3913-24 pubmed
    ..Herein, we investigated whether any of these regulatory pathways in the enteropathogen Yersinia pseudotuberculosis affect the functionality of the Ysc-Yop type III secretion system...
  39. Palonen E, Lindstrom M, Somervuo P, Johansson P, Björkroth J, Korkeala H. Requirement for RNA helicase CsdA for growth of Yersinia pseudotuberculosis IP32953 at low temperatures. Appl Environ Microbiol. 2012;78:1298-301 pubmed publisher
    The expression of csdA, encoding an RNA helicase, was induced at 3°C in Yersinia pseudotuberculosis. The role of CsdA in Y. pseudotuberculosis under cold conditions was confirmed by impaired growth of insertional csdA mutants at 3°C...
  40. Zhang W, Wang Y, Song Y, Wang T, Xu S, Peng Z, et al. A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ Microbiol. 2013;15:557-69 pubmed publisher
    ..We have recently identified a thermoregulated T6SS4 in the enteric pathogen Yersinia pseudotuberculosis. Here we report that OmpR directly binds to the promoter of T6SS4 operon and regulates its expression...
  41. Palonen E, Lindstrom M, Karttunen R, Somervuo P, Korkeala H. Expression of signal transduction system encoding genes of Yersinia pseudotuberculosis IP32953 at 28°C and 3°C. PLoS ONE. 2011;6:e25063 pubmed publisher
    b>Yersinia pseudotuberculosis is a significant psychrotrophic food pathogen whose cold tolerance mechanisms are poorly understood...
  42. Dessein R, Gironella M, Vignal C, Peyrin Biroulet L, Sokol H, Secher T, et al. Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis. Gut. 2009;58:771-6 pubmed publisher
    b>Yersinia pseudotuberculosis causes ileitis and mesenteric lymphadenitis by mainly invading the Peyer's patches that are positioned in the terminal ileum...
  43. Liu J, Obi I, Thanikkal E, Kieselbach T, Francis M. Phosphorylated CpxR restricts production of the RovA global regulator in Yersinia pseudotuberculosis. PLoS ONE. 2011;6:e23314 pubmed publisher
    ..In the enteropathogen Y. pseudotuberculosis, we have previously reported that the extracytoplasmic stress sensing CpxA-CpxR two-component regulatory system modulates rovA expression...
  44. Zhang Y, Ting A, Marcu K, Bliska J. Inhibition of MAPK and NF-kappa B pathways is necessary for rapid apoptosis in macrophages infected with Yersinia. J Immunol. 2005;174:7939-49 pubmed
    ..Macrophages expressing these proteins were infected with Yersinia pseudotuberculosis strains that secrete functionally active or inactive forms of YopJ...
  45. Pouillot F, Derbise A, Kukkonen M, Foulon J, Korhonen T, Carniel E. Evaluation of O-antigen inactivation on Pla activity and virulence of Yersinia pseudotuberculosis harbouring the pPla plasmid. Microbiology. 2005;151:3759-68 pubmed
    Yersinia pestis is a species that emerged recently from Yersinia pseudotuberculosis and gained an exceptional pathogenicity potential...
  46. Laws T, Davey M, Green C, Cooper I, Titball R, Lukaszewski R. Yersinia pseudotuberculosis is resistant to killing by human neutrophils. Microbes Infect. 2011;13:607-11 pubmed publisher
    The interaction between human neutrophils and the Gram negative gastrointestinal pathogen Yersinia pseudotuberculosis was investigated in vitro...
  47. Niskanen T, Waldenstrom J, Fredriksson Ahomaa M, Olsen B, Korkeala H. virF-positive Yersinia pseudotuberculosis and Yersinia enterocolitica found in migratory birds in Sweden. Appl Environ Microbiol. 2003;69:4670-5 pubmed
  48. Quade N, Mendonca C, Herbst K, Heroven A, Ritter C, Heinz D, et al. Structural basis for intrinsic thermosensing by the master virulence regulator RovA of Yersinia. J Biol Chem. 2012;287:35796-803 pubmed publisher
    ..In conclusion, only minor alterations can transform a thermotolerant regulator into a thermosensor that allows adjustment of virulence and fitness determinants to their thermal environment...
  49. Kauppi A, Nordfelth R, Uvell H, Wolf Watz H, Elofsson M. Targeting bacterial virulence: inhibitors of type III secretion in Yersinia. Chem Biol. 2003;10:241-9 pubmed
    ..Screening of a chemical library with a luciferase reporter gene assay in viable Yersinia pseudotuberculosis furnished several compounds that inhibit the reporter gene signal expressed from the yopE promoter and ..
  50. Champion O, Karlyshev A, Cooper I, Ford D, Wren B, Duffield M, et al. Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1. Microbiology. 2011;157:1115-22 pubmed publisher
    ..In this study we confirm that a null mutation in Yersinia pseudotuberculosis mntH reduces intracellular manganese accumulation...
  51. Fisher M, Castillo C, Mecsas J. Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP. Infect Immun. 2007;75:429-42 pubmed
    b>Yersinia pseudotuberculosis infects many mammals and birds including humans, livestock, and wild rodents and can be recovered from the lungs of infected animals. To determine the Y...
  52. Bogdanovich T, Carniel E, Fukushima H, Skurnik M. Genetic (sero) typing of Yersinia pseudotuberculosis. Adv Exp Med Biol. 2003;529:337-40 pubmed
  53. Eppinger M, Rosovitz M, Fricke W, Rasko D, Kokorina G, Fayolle C, et al. The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever. PLoS Genet. 2007;3:e142 pubmed
    ..The causative agent was later identified as Yersinia pseudotuberculosis, although the range of morbidities was vastly different from classical pseudotuberculosis symptoms...
  54. Henry A, Shanks J, van Hoof A, Rosenzweig J. The Yersinia pseudotuberculosis degradosome is required for oxidative stress, while its PNPase subunit plays a degradosome-independent role in cold growth. FEMS Microbiol Lett. 2012;336:139-47 pubmed publisher
    ..These data suggest that while the Yersinia pseudotuberculosis PNPase plays a role in the oxidative stress response through a degradosome-dependent mechanism, PNPase'..
  55. Pujol C, Bliska J. The ability to replicate in macrophages is conserved between Yersinia pestis and Yersinia pseudotuberculosis. Infect Immun. 2003;71:5892-9 pubmed
    Yersinia pestis, the agent of plague, has arisen from a less virulent pathogen, Yersinia pseudotuberculosis, by a rapid evolutionary process. Although Y...
  56. Bogdanovich T, Carniel E, Fukushima H, Skurnik M. Use of O-antigen gene cluster-specific PCRs for the identification and O-genotyping of Yersinia pseudotuberculosis and Yersinia pestis. J Clin Microbiol. 2003;41:5103-12 pubmed
    Yersinia pestis is a very recently evolved clone of Yersinia pseudotuberculosis serotype O:1b. This close relationship causes potential difficulties in DNA-based diagnostic methods...
  57. Matero P, Pasanen T, Laukkanen R, Tissari P, Tarkka E, Vaara M, et al. Real-time multiplex PCR assay for detection of Yersinia pestis and Yersinia pseudotuberculosis. APMIS. 2009;117:34-44 pubmed publisher
    ..real-time polymerase chain reaction (PCR) assay was developed for the detection of Yersinia pestis and Yersinia pseudotuberculosis. The assay includes four primer pairs, two of which are specific for Y. pestis, one for Y. pestis and Y...
  58. Pinheiro V, Ellar D. Expression and insecticidal activity of Yersinia pseudotuberculosis and Photorhabdus luminescens toxin complex proteins. Cell Microbiol. 2007;9:2372-80 pubmed
    ..In particular, tc gene homologues have been identified in Yersinia enterocolitica, Yersinia pseudotuberculosis and Yersinia pestis and may have a role in Y. pestis evolution. Y...
  59. Roy D, Liston D, Idone V, Di A, Nelson D, Pujol C, et al. A process for controlling intracellular bacterial infections induced by membrane injury. Science. 2004;304:1515-8 pubmed
    ..Thus, the lysosomal repair response can also protect cells against pathogens that trigger membrane permeabilization...
  60. Wiedig C, Kramer U, Garbom S, Wolf Watz H, Autenrieth I. Induction of CD8+ T cell responses by Yersinia vaccine carrier strains. Vaccine. 2005;23:4984-98 pubmed
    ..In conclusion, Yersinia live carrier vaccine strains are suitable to target antigens into the MHC class I pathway and stimulate CD8+ T cell responses and thus, might be useful in vaccine approaches against intracellular pathogens...
  61. Bergsbaken T, Cookson B. Innate immune response during Yersinia infection: critical modulation of cell death mechanisms through phagocyte activation. J Leukoc Biol. 2009;86:1153-8 pubmed publisher
    ..This organism shares important attributes with its ancestral progenitor, Yersinia pseudotuberculosis, including a 70-kb virulence plasmid, lymphotropism during growth in the mammalian host, and killing of ..
  62. Antinori A, Paglia M, Marconi P, Festa A, Alba L, Boumis E, et al. Short Communication: Yersinia pseudotuberculosis septicemia in an HIV-infected patient failed HAART. AIDS Res Hum Retroviruses. 2004;20:709-10 pubmed
    The first case of septicemia due to Yersinia pseudotuberculosis in an HIV-infected person was reported. The 42-year-old woman was severely immunosuppressed despite a prolonged exposure to HAART...
  63. Hudson K, Bouton A. Yersinia pseudotuberculosis adhesins regulate tissue-specific colonization and immune cell localization in a mouse model of systemic infection. Infect Immun. 2006;74:6487-90 pubmed
    b>Yersinia pseudotuberculosis mutants deficient for the adhesins invasin and/or YadA were injected intravenously into BALB/c mice. Invasin expression inhibited colonization of the liver and spleen...
  64. Monnazzi L, Carlos I, de Medeiros B. Influence of Yersinia pseudotuberculosis outer proteins (Yops) on interleukin-12, tumor necrosis factor alpha and nitric oxide production by peritoneal macrophages. Immunol Lett. 2004;94:91-8 pubmed
    ..The aim of this study was to assess the influence of Yersinia outer proteins (Yops) released by Yersinia pseudotuberculosis on the production of the proinflammatory cytokines, interleukin-12 (IL-12), and tumor necrosis factor ..
  65. Björnfot A, Lavander M, Forsberg A, Wolf Watz H. Autoproteolysis of YscU of Yersinia pseudotuberculosis is important for regulation of expression and secretion of Yop proteins. J Bacteriol. 2009;191:4259-67 pubmed publisher
    ..The N263A mutant was cytotoxic for HeLa cells, demonstrating that the T3SS-mediated delivery of effectors was functional. We suggest that YscU blocks Yop release and that autoproteolysis is required to relieve this block...
  66. Tan L, Darby C. A movable surface: formation of Yersinia sp. biofilms on motile Caenorhabditis elegans. J Bacteriol. 2004;186:5087-92 pubmed
    ..Furthermore, biofilm accumulation depends on continuous C. elegans exposure to a lawn of Yersinia bacteria...
  67. Harmon D, Davis A, Castillo C, Mecsas J. Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis. Antimicrob Agents Chemother. 2010;54:3241-54 pubmed publisher
    ..b>Yersinia pseudotuberculosis requires the translocation of a group of effector molecules, called Yops, to subvert the innate immune ..
  68. Moreau K, Lacas Gervais S, Fujita N, Sebbane F, Yoshimori T, Simonet M, et al. Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages. Cell Microbiol. 2010;12:1108-23 pubmed publisher
    b>Yersinia pseudotuberculosis is able to replicate inside macrophages. However, the intracellular trafficking of the pathogen after its entry into the macrophage remains poorly understood...
  69. Fairman J, Dautin N, Wójtowicz D, Liu W, Noinaj N, Barnard T, et al. Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis. Structure. 2012;20:1233-43 pubmed publisher
    ..We then use this set of sequences along with our structural data to find and map the evolutionarily constrained residues within the β domain. ..
  70. Joshua G, Karlyshev A, Smith M, Isherwood K, Titball R, Wren B. A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface. Microbiology. 2003;149:3221-9 pubmed
    ..Similarly, 15 strains of Yersinia enterocolitica caused no effect. Strains of Yersinia pseudotuberculosis showed different levels of pathogenicity...
  71. Skurnik M, Bengoechea J. The biosynthesis and biological role of lipopolysaccharide O-antigens of pathogenic Yersiniae. Carbohydr Res. 2003;338:2521-9 pubmed
  72. Flores Kim J, Darwin A. Links between type III secretion and extracytoplasmic stress responses in Yersinia. Front Cell Infect Microbiol. 2012;2:125 pubmed publisher
    ..Instead, Ysc-Yop T3SS production induces the Psp system, which then mitigates T3SS-induced envelope stress. Consequently, the Y. enterocolitica Psp system is essential when the Ysc-Yop T3SS is produced...
  73. Collyn F, Fukushima H, Carnoy C, Simonet M, Vincent P. Linkage of the horizontally acquired ypm and pil genes in Yersinia pseudotuberculosis. Infect Immun. 2005;73:2556-8 pubmed
    ..ypm gene and the pil gene cluster governing type IV pilus biogenesis have been laterally acquired by Yersinia pseudotuberculosis. PCR assays on 270 unrelated strains from various environmental and animal sources revealed a ..
  74. Auerbuch V, Isberg R. Growth of Yersinia pseudotuberculosis in mice occurs independently of Toll-like receptor 2 expression and induction of interleukin-10. Infect Immun. 2007;75:3561-70 pubmed
    ..To determine whether TLR2 also plays a role in recognition of the enteropathogen Yersinia pseudotuberculosis and whether this results in an immune response that is detrimental to the host, we evaluated the ..
  75. Blumenthal B, Hoffmann C, Aktories K, Backert S, Schmidt G. The cytotoxic necrotizing factors from Yersinia pseudotuberculosis and from Escherichia coli bind to different cellular receptors but take the same route to the cytosol. Infect Immun. 2007;75:3344-53 pubmed
    ..necrotizing factors CNF1 and CNF2 produced by pathogenic Escherichia coli strains and CNF(Y) of Yersinia pseudotuberculosis constitutively activate small GTPases of the Rho family...
  76. Kwuan L, Adams W, Auerbuch V. Impact of host membrane pore formation by the Yersinia pseudotuberculosis type III secretion system on the macrophage innate immune response. Infect Immun. 2013;81:905-14 pubmed publisher
    ..To test these models, we constructed a Yersinia pseudotuberculosis mutant expressing YopD devoid of its predicted transmembrane domain (YopD(?TM)) and lacking the T3SS ..
  77. Grabenstein J, Marceau M, Pujol C, Simonet M, Bliska J. The response regulator PhoP of Yersinia pseudotuberculosis is important for replication in macrophages and for virulence. Infect Immun. 2004;72:4973-84 pubmed
    Yersinia pestis and Yersinia pseudotuberculosis are closely related facultative intracellular pathogens. The response regulator PhoP was previously shown to be important for Y...
  78. Lavander M, Ericsson S, Bröms J, Forsberg A. The twin arginine translocation system is essential for virulence of Yersinia pseudotuberculosis. Infect Immun. 2006;74:1768-76 pubmed
    ..A Yersinia pseudotuberculosis mutant strain with a disrupted Tat system (tatC) was, however, not affected in in vitro growth or more ..
  79. Collyn F, Billault A, Mullet C, Simonet M, Marceau M. YAPI, a new Yersinia pseudotuberculosis pathogenicity island. Infect Immun. 2004;72:4784-90 pubmed
    ..In the Yersinia pseudotuberculosis 32777 chromosome, we characterized a 98-kb segment that has all of the characteristic features of a PAI,..
  80. Zolotukhina M, Ovcharova I, Eremina S, Errais Lopes L, Mironov A. Comparison of the structure and regulation of the udp gene of Vibrio cholerae, Yersinia pseudotuberculosis, Salmonella typhimurium, and Escherichia coli. Res Microbiol. 2003;154:510-20 pubmed publisher
    The nucleotide sequences of the udp gene encoding uridine phosphorylase of Yersinia pseudotuberculosis and Vibrio cholerae are presented and compared with the udp sequences of Salmonella typhimurium and Escherichia coli...
  81. Davis A, Mecsas J. Mutations in the Yersinia pseudotuberculosis type III secretion system needle protein, YscF, that specifically abrogate effector translocation into host cells. J Bacteriol. 2007;189:83-97 pubmed
    ..Furthermore, the identification of YscF residues that are required for the assembly of the translocon and/or productive interactions with the translocon has allowed us to initiate the mapping of the needle-translocon interface...
  82. Donadini R, Liew C, Kwan A, Mackay J, Fields B. Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold. Structure. 2004;12:145-56 pubmed
    ..b>Yersinia pseudotuberculosis produces superantigens, YPMa, YPMb, and YPMc, which have no significant amino acid similarity to other ..
  83. Mejia E, Bliska J, Viboud G. Yersinia controls type III effector delivery into host cells by modulating Rho activity. PLoS Pathog. 2008;4:e3 pubmed publisher
    b>Yersinia pseudotuberculosis binds to beta1 integrin receptors, and uses the type III secretion proteins YopB and YopD to introduce pores and to translocate Yop effectors directly into host cells. Y...
  84. Hallanvuo S, Nuorti P, Nakari U, Siitonen A. Molecular epidemiology of the five recent outbreaks of Yersinia pseudotuberculosis in Finland. Adv Exp Med Biol. 2003;529:309-12 pubmed
  85. Lavander M, Sundberg L, Edqvist P, Lloyd S, Wolf Watz H, Forsberg A. Characterisation of the type III secretion protein YscU in Yersinia pseudotuberculosis. YscU cleavage--dispensable for TTSS but essential for survival. Adv Exp Med Biol. 2003;529:109-12 pubmed
  86. Gerke C, Falkow S, Chien Y. The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation. J Exp Med. 2005;201:361-71 pubmed
    ..phosphorylation levels of LAT and SLP-76 are the most affected in T cells exposed to low numbers of Yersinia pseudotuberculosis. This is the first example showing that a pathogen targets these adaptor proteins in the TCR signaling ..
  87. Kenyon J, De Castro C, Cunneen M, Reeves P, Molinaro A, Holst O, et al. The genetics and structure of the O-specific polysaccharide of Yersinia pseudotuberculosis serotype O:10 and its relationship with Escherichia coli O111 and Salmonella enterica O35. Glycobiology. 2011;21:1131-9 pubmed publisher
    ..of OPSs within a species is usually first defined serologically, and the current serotyping scheme for Yersinia pseudotuberculosis consists of 21 O serotypes of which 15 have been characterized genetically and structurally...
  88. Bergman M, Loomis W, Mecsas J, Starnbach M, Isberg R. CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells. PLoS Pathog. 2009;5:e1000573 pubmed publisher
  89. Tansini A, de Medeiros B. Susceptibility to Yersinia pseudotuberculosis infection is linked to the pattern of macrophage activation. Scand J Immunol. 2009;69:310-8 pubmed publisher
    T helper 1 cells play a crucial role in the clearance of Yersinia pseudotuberculosis infection. By producing cytokines and presenting antigens to T cells, activated macrophages can orientate the adaptive immune response...
  90. Ding L, Wang Y, Hu Y, Atkinson S, Williams P, Chen S. Functional characterization of FlgM in the regulation of flagellar synthesis and motility in Yersinia pseudotuberculosis. Microbiology. 2009;155:1890-900 pubmed publisher
    We describe here the functional characterization of the flgM gene in Yersinia pseudotuberculosis. Direct interaction of FlgM with the alternative sigma factor sigma(28) (FliA) was first confirmed...