yersinia pestis

Summary

Summary: The etiologic agent of PLAGUE in man, rats, ground squirrels, and other rodents.

Top Publications

  1. Morelli G, Song Y, Mazzoni C, Eppinger M, Roumagnac P, Wagner D, et al. Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity. Nat Genet. 2010;42:1140-3 pubmed publisher
    Plague is a pandemic human invasive disease caused by the bacterial agent Yersinia pestis. We here report a comparison of 17 whole genomes of Y. pestis isolates from global sources. We also screened a global collection of 286 Y...
  2. Webb Robertson B, Cannon W, Oehmen C, Shah A, Gurumoorthi V, Lipton M, et al. A support vector machine model for the prediction of proteotypic peptides for accurate mass and time proteomics. Bioinformatics. 2010;26:1677-83 pubmed
    ..Using three independently derived AMT databases (Shewanella oneidensis, Salmonella typhimurium, Yersinia pestis) for training and validation within and across species, the SVM resulted in an average accuracy measure of ..
  3. Kolodziejek A, Schnider D, Rohde H, Wojtowicz A, Bohach G, Minnich S, et al. Outer membrane protein X (Ail) contributes to Yersinia pestis virulence in pneumonic plague and its activity is dependent on the lipopolysaccharide core length. Infect Immun. 2010;78:5233-43 pubmed publisher
    b>Yersinia pestis, the causative agent of plague, is one of the most virulent microorganisms known. The outer membrane protein X (OmpX) in Y...
  4. Bertherat E, Thullier P, Shako J, England K, Kone M, Arntzen L, et al. Lessons learned about pneumonic plague diagnosis from two outbreaks, Democratic Republic of the Congo. Emerg Infect Dis. 2011;17:778-84 pubmed publisher
    ..This prompted modifications in diagnostic strategies, resulting in isolation of Yersinia pestis during the second outbreak...
  5. Swietnicki W, Carmany D, Retford M, Guelta M, Dorsey R, Bozue J, et al. Identification of small-molecule inhibitors of Yersinia pestis Type III secretion system YscN ATPase. PLoS ONE. 2011;6:e19716 pubmed publisher
    b>Yersinia pestis is a gram negative zoonotic pathogen responsible for causing bubonic and pneumonic plague in humans...
  6. Pechous R, Sivaraman V, Price P, Stasulli N, Goldman W. Early host cell targets of Yersinia pestis during primary pneumonic plague. PLoS Pathog. 2013;9:e1003679 pubmed publisher
    Inhalation of Yersinia pestis causes primary pneumonic plague, a highly lethal syndrome with mortality rates approaching 100%...
  7. Williamson E, Oyston P. The natural history and incidence of Yersinia pestis and prospects for vaccination. J Med Microbiol. 2012;61:911-8 pubmed publisher
    ..The considerable challenges in achieving a vaccine which is licensed for human use and which will comprehensively protect against this serious human pathogen are assessed...
  8. Peters K, Dhariwala M, Hughes Hanks J, Brown C, Anderson D. Early apoptosis of macrophages modulated by injection of Yersinia pestis YopK promotes progression of primary pneumonic plague. PLoS Pathog. 2013;9:e1003324 pubmed publisher
    b>Yersinia pestis causes pneumonic plague, a disease characterized by inflammation, necrosis and rapid bacterial growth which together cause acute lung congestion and lethality...
  9. Turingan R, Thomann H, Zolotova A, Tan E, Selden R. Rapid focused sequencing: a multiplexed assay for simultaneous detection and strain typing of Bacillus anthracis, Francisella tularensis, and Yersinia pestis. PLoS ONE. 2013;8:e56093 pubmed publisher
    ..the deadliest bacteria, including the Class A Select Agents Bacillus anthracis, Francisella tularensis, and Yersinia pestis, are highly infectious via the pulmonary route when released in aerosolized form...

More Information

Publications100

  1. Charusanti P, Chauhan S, McAteer K, Lerman J, Hyduke D, Motin V, et al. An experimentally-supported genome-scale metabolic network reconstruction for Yersinia pestis CO92. BMC Syst Biol. 2011;5:163 pubmed publisher
    b>Yersinia pestis is a gram-negative bacterium that causes plague, a disease linked historically to the Black Death in Europe during the Middle Ages and to several outbreaks during the modern era. Metabolism in Y...
  2. Brown H, Levy C, Enscore R, Schriefer M, DeLiberto T, Gage K, et al. Annual seroprevalence of Yersinia pestis in coyotes as predictors of interannual variation in reports of human plague cases in Arizona, United States. Vector Borne Zoonotic Dis. 2011;11:1439-46 pubmed publisher
    ..2,276 coyote blood samples from four Arizona counties were tested for serological evidence of exposure to Yersinia pestis, the causative agent of plague...
  3. Sebbane F, Jarrett C, Gardner D, Long D, Hinnebusch B. Role of the Yersinia pestis yersiniabactin iron acquisition system in the incidence of flea-borne plague. PLoS ONE. 2010;5:e14379 pubmed publisher
    Plague is a flea-borne zoonosis caused by the bacterium Yersinia pestis. Y...
  4. Ayyadurai S, Flaudrops C, Raoult D, Drancourt M. Rapid identification and typing of Yersinia pestis and other Yersinia species by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. BMC Microbiol. 2010;10:285 pubmed publisher
    ..Yersinia enterocolitica and Yersinia pseudotuberculosis and from the group A bioterrorism plague agent Yersinia pestis. In order to circumvent the limitations of current phenotypic and PCR-based identification methods, we aimed ..
  5. Wojciechowski J, Danley D, Cooper J, Yazvenko N, Taitt C. Multiplexed electrochemical detection of Yersinia pestis and staphylococcal enterotoxin B using an antibody microarray. Sensors (Basel). 2010;10:3351-62 pubmed publisher
    ..microelectrodes coupled to an adjacent bio-friendly matrix coated with antibodies to the biological pathogens Yersinia pestis and Bacillus anthracis, and the bacterial toxin staphylococcal enterotoxin B (SEB)...
  6. Demeure C, Blanchet C, Fitting C, Fayolle C, Khun H, Szatanik M, et al. Early systemic bacterial dissemination and a rapid innate immune response characterize genetic resistance to plague of SEG mice. J Infect Dis. 2012;205:134-43 pubmed publisher
    Although laboratory mice are usually highly susceptible to Yersinia pestis, we recently identified a mouse strain (SEG) that exhibited an exceptional capacity to resist bubonic plague and used it to identify immune mechanisms associated ..
  7. Yang H, Tan Y, Zhang T, Tang L, Wang J, Ke Y, et al. Identification of novel protein-protein interactions of Yersinia pestis type III secretion system by yeast two hybrid system. PLoS ONE. 2013;8:e54121 pubmed publisher
    ..Here in this report, interactions among the possible components in T3SS of Yersinia pestis were identified using yeast mating technique...
  8. Cui Y, Yu C, Yan Y, Li D, Li Y, Jombart T, et al. Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis. Proc Natl Acad Sci U S A. 2013;110:577-82 pubmed publisher
    The genetic diversity of Yersinia pestis, the etiologic agent of plague, is extremely limited because of its recent origin coupled with a slow clock rate. Here we identified 2,326 SNPs from 133 genomes of Y...
  9. Patel A, Lee Lewis H, Hughes Hanks J, Lewis C, Anderson D. Opposing roles for interferon regulatory factor-3 (IRF-3) and type I interferon signaling during plague. PLoS Pathog. 2012;8:e1002817 pubmed publisher
    ..In this work, we addressed the role of type I IFN during Yersinia pestis infection in a murine model of septicemic plague...
  10. Yamashita S, Lukacik P, Barnard T, Noinaj N, Felek S, Tsang T, et al. Structural insights into Ail-mediated adhesion in Yersinia pestis. Structure. 2011;19:1672-82 pubmed publisher
    Ail is an outer membrane protein from Yersinia pestis that is highly expressed in a rodent model of bubonic plague, making it a good candidate for vaccine development...
  11. Li B, Tan Y, Guo J, Cui B, Wang Z, Wang H, et al. Use of protein microarray to identify gene expression changes of Yersinia pestis at different temperatures. Can J Microbiol. 2011;57:287-94 pubmed publisher
    b>Yersinia pestis is a bacterium that is transmitted between fleas, which have a body temperature of 26 °C, and mammalian hosts, which have a body temperature of 37 °C...
  12. Achtman M. Insights from genomic comparisons of genetically monomorphic bacterial pathogens. Philos Trans R Soc Lond B Biol Sci. 2012;367:860-7 pubmed publisher
    ..g. the cause of plague, Yersinia pestis. Based on recent results, it is now possible to reconstruct the sources and the history of pandemic waves of ..
  13. Leslie T, Whitehouse C, Yingst S, Baldwin C, Kakar F, Mofleh J, et al. Outbreak of gastroenteritis caused by Yersinia pestis in Afghanistan. Epidemiol Infect. 2011;139:728-35 pubmed publisher
    Plague, which is most often caused by the bite of Yersinia pestis-infected fleas, is a rapidly progressing, serious disease that can be fatal without prompt antibiotic treatment...
  14. Yan Y, Su S, Meng X, Ji X, Qu Y, Liu Z, et al. Determination of sRNA expressions by RNA-seq in Yersinia pestis grown in vitro and during infection. PLoS ONE. 2013;8:e74495 pubmed publisher
    ..pestis pathogenesis. However, information on how Yersinia pestis modulates the expression of sRNAs during infection is largely unknown...
  15. Tsangaras K, Greenwood A. Museums and disease: using tissue archive and museum samples to study pathogens. Ann Anat. 2012;194:58-73 pubmed publisher
    ..This article reviews the advantages, problems, and failures of ancient microbiological research. ..
  16. Wendte J, Ponnusamy D, Reiber D, Blair J, Clinkenbeard K. In vitro efficacy of antibiotics commonly used to treat human plague against intracellular Yersinia pestis. Antimicrob Agents Chemother. 2011;55:3752-7 pubmed publisher
    b>Yersinia pestis initiates infection as a facultative intracellular parasite in host macrophages; however, little is known about the efficacy of antibiotics commonly used to treat human plague against intracellular Y. pestis...
  17. Chung H, Raetz C. Dioxygenases in Burkholderia ambifaria and Yersinia pestis that hydroxylate the outer Kdo unit of lipopolysaccharide. Proc Natl Acad Sci U S A. 2011;108:510-5 pubmed publisher
    Several gram-negative pathogens, including Yersinia pestis, Burkholderia cepacia, and Acinetobacter haemolyticus, synthesize an isosteric analog of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo), known as D-glycero-D-talo-oct-2-ulosonic acid (..
  18. Bozue J, Cote C, Webster W, Bassett A, Tobery S, Little S, et al. A Yersinia pestis YscN ATPase mutant functions as a live attenuated vaccine against bubonic plague in mice. FEMS Microbiol Lett. 2012;332:113-21 pubmed publisher
    b>Yersinia pestis is the causative agent responsible for bubonic and pneumonic plague. The bacterium uses the pLcr plasmid-encoded type III secretion system to deliver virulence factors into host cells...
  19. Houppert A, Kwiatkowski E, Glass E, Debord K, Merritt P, Schneewind O, et al. Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells. PLoS ONE. 2012;7:e34039 pubmed publisher
    ..the contribution of chromosomal genes to the complex regulatory process controlling type III secretion in Yersinia pestis. Using transposon mutagenesis, we identified five chromosomal genes required for expression or secretion of ..
  20. Plano G, Schesser K. The Yersinia pestis type III secretion system: expression, assembly and role in the evasion of host defenses. Immunol Res. 2013;57:237-45 pubmed publisher
    b>Yersinia pestis, the etiologic agent of plague, utilizes a type III secretion system (T3SS) to subvert the defenses of its mammalian hosts...
  21. Perry R, Fetherston J. Yersiniabactin iron uptake: mechanisms and role in Yersinia pestis pathogenesis. Microbes Infect. 2011;13:808-17 pubmed publisher
    ..The Ybt system is essential for the ability of Yersinia pestis to cause bubonic plague and important in pneumonic plague as well...
  22. Sun Y, Koumoutsi A, Jarrett C, Lawrence K, Gherardini F, Darby C, et al. Differential control of Yersinia pestis biofilm formation in vitro and in the flea vector by two c-di-GMP diguanylate cyclases. PLoS ONE. 2011;6:e19267 pubmed publisher
    b>Yersinia pestis forms a biofilm in the foregut of its flea vector that promotes transmission by flea bite. As in many bacteria, biofilm formation in Y...
  23. Qiu Y, Liu Y, Qi Z, Wang W, Kou Z, Zhang Q, et al. Comparison of immunological responses of plague vaccines F1+rV270 and EV76 in Chinese-origin rhesus macaque, Macaca mulatta. Scand J Immunol. 2010;72:425-33 pubmed publisher
    ..subunit vaccine (SV) had an advantage over EV76 in terms of the indispensable role of anti-V antibody against Yersinia pestis. There was no significant antibody titre difference between SV1 and SV2, suggesting that the immune response ..
  24. Bobrov A, Kirillina O, Ryjenkov D, Waters C, Price P, Fetherston J, et al. Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis. Mol Microbiol. 2011;79:533-51 pubmed publisher
    ..we systematically examine the functionality of the genes encoding putative c-di-GMP metabolic enzymes in Yersinia pestis. We determine that, in addition to hmsT and hmsP, only the gene y3730 encodes a functional enzyme capable of ..
  25. Uittenbogaard A, Chelvarajan R, Myers Morales T, Gorman A, Brickey W, Ye Z, et al. Toward a molecular pathogenic pathway for Yersinia pestis YopM. Front Cell Infect Microbiol. 2012;2:155 pubmed publisher
    ..These studies revealed novel early transcriptional effects of YopM but point to a time after 18 h of infection when critical transitional events lead to later major effects on cytokine gene transcription...
  26. Weening E, Cathelyn J, Kaufman G, Lawrenz M, Price P, Goldman W, et al. The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background. Infect Immun. 2011;79:644-52 pubmed publisher
    b>Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of bubonic and pneumonic plague. Y...
  27. Ulery B, Kumar D, Ramer Tait A, Metzger D, Wannemuehler M, Narasimhan B. Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases. PLoS ONE. 2011;6:e17642 pubmed publisher
  28. Lane M, Lenz J, Miller V. Proteolytic processing of the Yersinia pestis YapG autotransporter by the omptin protease Pla and the contribution of YapG to murine plague pathogenesis. J Med Microbiol. 2013;62:1124-34 pubmed publisher
    ..To better understand the role of autotransporters in disease, our research focused on the autotransporters of Yersinia pestis, the aetiological agent of plague. Y...
  29. Oliveira M, Barros M, Silveira Filho V, Araújo Nepomuceno M, Balbino V, Leal N, et al. Genetic diversity of Yersinia pestis in Brazil. Genet Mol Res. 2012;11:3414-24 pubmed publisher
    ..We conclude that there is some correlation among genetic groups of this species, related to the temporal and geographic origin of isolates. ..
  30. Janse I, Bok J, Hamidjaja R, Hodemaekers H, van Rotterdam B. Development and comparison of two assay formats for parallel detection of four biothreat pathogens by using suspension microarrays. PLoS ONE. 2012;7:e31958 pubmed publisher
    ..suspension microarrays for sensitive and specific detection of the biothreat pathogens Bacillus anthracis, Yersinia pestis, Francisella tularensis and Coxiella burnetii...
  31. Sun W, Six D, Kuang X, Roland K, Raetz C, Curtiss R. A live attenuated strain of Yersinia pestis KIM as a vaccine against plague. Vaccine. 2011;29:2986-98 pubmed publisher
    b>Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y...
  32. Weller S, Cox V, Essex Lopresti A, Hartley M, Parsons T, Rachwal P, et al. Evaluation of two multiplex real-time PCR screening capabilities for the detection of Bacillus anthracis, Francisella tularensis and Yersinia pestis in blood samples generated from murine infection models. J Med Microbiol. 2012;61:1546-55 pubmed publisher
    ..and FilmArray) were evaluated for their ability to detect Bacillus anthracis, Francisella tularensis and Yersinia pestis in blood samples obtained from respective murine infection models...
  33. Busch J, Van Andel R, Cordova J, Colman R, Keim P, Rocke T, et al. Population differences in host immune factors may influence survival of Gunnison's prairie dogs (Cynomys gunnisoni) during plague outbreaks. J Wildl Dis. 2011;47:968-73 pubmed
    Over the past 40 yr, epizootics of plague (Yersinia pestis) in northern Arizona have reduced populations of the Gunnison's prairie dog (Cynomys gunnisoni), with the exception of a large population found in the Aubrey Valley (AV)...
  34. Bhattacharya D, Mecsas J, Hu L. Development of a vaccinia virus based reservoir-targeted vaccine against Yersinia pestis. Vaccine. 2010;28:7683-9 pubmed publisher
    b>Yersinia pestis, the causative organism of plague, is a zoonotic organism with a worldwide distribution. Although the last plague epidemic occurred in early 1900s, human cases continue to occur due to contact with infected wild animals...
  35. Simon S, Demeure C, Lamourette P, Filali S, Plaisance M, Creminon C, et al. Fast and simple detection of Yersinia pestis applicable to field investigation of plague foci. PLoS ONE. 2013;8:e54947 pubmed publisher
    b>Yersinia pestis, the plague bacillus, has a rodent-flea-rodent life cycle but can also persist in the environment for various periods of time. There is now a convenient and effective test (F1-dipstick) for the rapid identification of Y...
  36. Saavedra R, Dias J. [Yersinia pestis infection in the State of Bahia: effective control or epidemiological silence?]. Rev Soc Bras Med Trop. 2011;44:223-7 pubmed
    ..Despite the absence of cases of human plague in Brazil, its etiologic agent, the bacteria Yersinia pestis, is still deep rooted in its natural environment...
  37. Andrianaivoarimanana V, Telfer S, Rajerison M, Ranjalahy M, Andriamiarimanana F, Rahaingosoamamitiana C, et al. Immune responses to plague infection in wild Rattus rattus, in Madagascar: a role in foci persistence?. PLoS ONE. 2012;7:e38630 pubmed publisher
    ..In addition, we evaluate the use of a recently developed rapid serological diagnostic test to investigate the immune response of potential reservoir hosts in plague foci...
  38. Ponnusamy D, Hartson S, Clinkenbeard K. Intracellular Yersinia pestis expresses general stress response and tellurite resistance proteins in mouse macrophages. Vet Microbiol. 2011;150:146-51 pubmed publisher
    b>Yersinia pestis inoculated subcutaneously via fleabite or experimental injection in natural rodent hosts multiply initially in macrophage phagolysosomes. Survival and multiplication of Y...
  39. Wang S, Goguen J, Li F, Lu S. Involvement of CD8+ T cell-mediated immune responses in LcrV DNA vaccine induced protection against lethal Yersinia pestis challenge. Vaccine. 2011;29:6802-9 pubmed publisher
    b>Yersinia pestis (Y. pestis) is the causative pathogen of plague, a highly fatal disease for which an effective vaccine, especially against mucosal transmission, is still not available...
  40. Spinner J, Carmody A, Jarrett C, Hinnebusch B. Role of Yersinia pestis toxin complex family proteins in resistance to phagocytosis by polymorphonuclear leukocytes. Infect Immun. 2013;81:4041-52 pubmed publisher
    b>Yersinia pestis carries homologues of the toxin complex (Tc) family proteins, which were first identified in other Gram-negative bacteria as having potent insecticidal activity. The Y...
  41. Ren G, Yan H, Zhu H, Guo X, Sun Y. HmsC, a periplasmic protein, controls biofilm formation via repression of HmsD, a diguanylate cyclase in Yersinia pestis. Environ Microbiol. 2014;16:1202-16 pubmed publisher
    b>Yersinia pestis, the cause of plague, forms a biofilm in the foregut of its flea vector to enhance transmission. Biofilm formation in Y...
  42. Beauregard A, Smith E, Petrone B, Singh N, Karch C, McDonough K, et al. Identification and characterization of small RNAs in Yersinia pestis. RNA Biol. 2013;10:397-405 pubmed publisher
    b>Yersinia pestis, the etiologic agent of plague, is closely related to Yersinia pseudotuberculosis evolutionarily but has a very different mode of infection...
  43. Ke Y, Chen Z, Yang R. Yersinia pestis: mechanisms of entry into and resistance to the host cell. Front Cell Infect Microbiol. 2013;3:106 pubmed publisher
    ..Here, we discuss those factors that seem to function reversely and give some hypothesis about how bacteria switch between the two distinct status. ..
  44. Felek S, Jeong J, Runco L, Murray S, Thanassi D, Krukonis E. Contributions of chaperone/usher systems to cell binding, biofilm formation and Yersinia pestis virulence. Microbiology. 2011;157:805-18 pubmed publisher
    b>Yersinia pestis genome sequencing projects have revealed six intact uncharacterized chaperone/usher systems with the potential to play roles in plague pathogenesis...
  45. Krishnadev O, Srinivasan N. Prediction of protein-protein interactions between human host and a pathogen and its application to three pathogenic bacteria. Int J Biol Macromol. 2011;48:613-9 pubmed publisher
    ..coli, Salmonella enterica typhimurium and Yersinia pestis. We identified several novel interactions involving proteins of host or pathogen that could be thought of as ..
  46. Tran T, Signoli M, Fozzati L, Aboudharam G, Raoult D, Drancourt M. High throughput, multiplexed pathogen detection authenticates plague waves in medieval Venice, Italy. PLoS ONE. 2011;6:e16735 pubmed publisher
    ..Historical records suggest that multiple burial sites from the 14th-16th centuries in Venice, Italy, were used during the Black Death and subsequent plague epidemics...
  47. Comer J, Sturdevant D, Carmody A, Virtaneva K, Gardner D, Long D, et al. Transcriptomic and innate immune responses to Yersinia pestis in the lymph node during bubonic plague. Infect Immun. 2010;78:5086-98 pubmed publisher
    A delayed inflammatory response is a prominent feature of infection with Yersinia pestis, the agent of bubonic and pneumonic plague...
  48. Lountos G, Tropea J, Waugh D. Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system. Acta Crystallogr D Biol Crystallogr. 2012;68:201-9 pubmed publisher
    The Yersinia pestis YscD protein is an essential component of the type III secretion system. YscD consists of an N-terminal cytoplasmic domain (residues 1-121), a transmembrane linker (122-142) and a large periplasmic domain (143-419)...
  49. Kolodziejek A, Caplan A, Bohach G, Paszczynski A, Minnich S, Hovde C. Physiological levels of glucose induce membrane vesicle secretion and affect the lipid and protein composition of Yersinia pestis cell surfaces. Appl Environ Microbiol. 2013;79:4509-14 pubmed publisher
    b>Yersinia pestis grown with physiologic glucose increased cell autoaggregation and deposition of extracellular material, including membrane vesicles...
  50. Torres R, Chim N, Sankaran B, Pujol C, Bliska J, Goulding C. Structural insights into RipC, a putative citrate lyase ? subunit from a Yersinia pestis virulence operon. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:2-7 pubmed publisher
    b>Yersinia pestis remains a threat, with outbreaks of plague occurring in rural areas and its emergence as a weapon of bioterrorism; thus, an improved understanding of its various pathogenicity pathways is warranted...
  51. del Rio B, Fuente J, Neves V, Dattwyler R, Seegers J, Gomes Solecki M. Platform technology to deliver prophylactic molecules orally: an example using the Class A select agent Yersinia pestis. Vaccine. 2010;28:6714-22 pubmed publisher
    ..technology can be applied to developing vaccines for other diseases by focusing on the Class A select agent, Yersinia pestis. We used a number of biochemistry and immunology techniques to determine the localization of the immunogen in ..
  52. Jones P, Britten H. The absence of concordant population genetic structure in the black-tailed prairie dog and the flea, Oropsylla hirsuta, with implications for the spread of Yersinia pestis. Mol Ecol. 2010;19:2038-49 pubmed publisher
    ..extirpations and isolation as a result of human activity including the introduction of an exotic pathogen, Yersinia pestis, the causative agent of sylvatic plague...
  53. Torres R, Swift R, Chim N, Wheatley N, Lan B, Atwood B, et al. Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis. PLoS ONE. 2011;6:e25084 pubmed publisher
    ..A subset of these pathogens has developed mechanisms to survive in human macrophages. Yersinia pestis, the causative agent of the bubonic plague, is a predominately extracellular pathogen with the ability to ..
  54. Valls Seron M, Haiko J, de Groot P, Korhonen T, Meijers J. Thrombin-activatable fibrinolysis inhibitor is degraded by Salmonella enterica and Yersinia pestis. J Thromb Haemost. 2010;8:2232-40 pubmed publisher
    ..In particular, the important bacterial pathogens Salmonella enterica and Yersinia pestis intervene with the plasminogen/fibrinolytic system...
  55. Kong C, Yu J, Minion F, Rajan K. Identification of biologically significant genes from combinatorial microarray data. ACS Comb Sci. 2011;13:562-71 pubmed publisher
    ..In this study, a series of microarray experimental data from Yersinia pestis (Y...
  56. Tsang T, Annis D, Kronshage M, Fenno J, Usselman L, Mosher D, et al. Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120-kDa region of fibronectin to facilitate cell binding by Yersinia pestis. J Biol Chem. 2012;287:16759-67 pubmed publisher
    The Yersinia pestis adhesin molecule Ail interacts with the extracellular matrix protein fibronectin (Fn) on host cells to facilitate efficient delivery of cytotoxic Yop proteins, a process essential for plague virulence...
  57. Jones A, Bosio C, Duffy A, Goodyear A, Schriefer M, Dow S. Protection against pneumonic plague following oral immunization with a non-replicating vaccine. Vaccine. 2010;28:5924-9 pubmed publisher
    b>Yersinia pestis is a dangerous bacterial pathogen that when inhaled can rapidly induce fatal pneumonic plague...
  58. Bhaduri S, Chaney Pope K, Smith J. A procedure for monitoring the presence of the virulence plasmid (pYV) in Yersinia pestis under culture conditions. Foodborne Pathog Dis. 2011;8:459-63 pubmed publisher
    The pathogenicity of Yersinia pestis depends on the presence of a virulence plasmid (pYV). The unstable nature of pYV in Y. pestis leads to the eventual outgrowth of pYV-less cells due to its higher growth rate...
  59. Deng Z, Meng X, Su S, Liu Z, Ji X, Zhang Y, et al. Two sRNA RyhB homologs from Yersinia pestis biovar microtus expressed in vivo have differential Hfq-dependent stability. Res Microbiol. 2012;163:413-8 pubmed publisher
    ..Maintenance of iron homeostasis is an essential step in the lifecycle of Yersinia pestis. Y. pestis encodes two RyhB homologs, RyhB1 and RyhB2. In this study, we found that as in the case of E...
  60. Seo K, Kim J, Park J, Viall A, Minnich S, Rohde H, et al. Role of a new intimin/invasin-like protein in Yersinia pestis virulence. Infect Immun. 2012;80:3559-69 pubmed publisher
    A comprehensive TnphoA mutant library was constructed in Yersinia pestis KIM6 to identify surface proteins involved in Y. pestis host cell invasion and bacterial virulence...
  61. Goulard C, Langrand S, Carniel E, Chauvaux S. The Yersinia pestis chromosome encodes active addiction toxins. J Bacteriol. 2010;192:3669-77 pubmed publisher
    ..In this study, we show that the chromosome of Yersinia pestis, the causative agent of plague, carries 10 putative TA modules and two solitary antitoxins that belong to ..
  62. Hong W, Huang L, Wang H, Qu J, Guo Z, Xie C, et al. Development of an up-converting phosphor technology-based 10-channel lateral flow assay for profiling antibodies against Yersinia pestis. J Microbiol Methods. 2010;83:133-40 pubmed publisher
    ..phosphor technology-based lateral flow (TC-UPT-LF) assay was developed to profile antibodies against Yersinia pestis. Ten expressed Y...
  63. Luo D, Lin J, Parent M, Mullarky Kanevsky I, Szaba F, Kummer L, et al. Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis. J Immunol. 2013;190:4149-61 pubmed publisher
    The Gram-negative bacterium Yersinia pestis causes plague, a rapidly progressing and often fatal disease. The formation of fibrin at sites of Y...
  64. Dentovskaya S, Anisimov A, Kondakova A, Lindner B, Bystrova O, Svetoch T, et al. Functional characterization and biological significance of Yersinia pestis lipopolysaccharide biosynthesis genes. Biochemistry (Mosc). 2011;76:808-22 pubmed publisher
    ..the phylogenetic proximity levels of enzymes responsible for biosynthesis of lipopolysaccharide (LPS) of Yersinia pestis, the cause of plague, to homologous proteins of closely related Yersinia spp...
  65. Yang F, Ke Y, Tan Y, Bi Y, Shi Q, Yang H, et al. Cell membrane is impaired, accompanied by enhanced type III secretion system expression in Yersinia pestis deficient in RovA regulator. PLoS ONE. 2010;5: pubmed publisher
    ..the expression of invasin, which is important for enteropathogenic pathogenesis but is inactivated in Yersinia pestis. Investigation of the RovA regulon in Y...
  66. Bartra S, Gong X, Lorica C, Jain C, Nair M, SCHIFFERLI D, et al. The outer membrane protein A (OmpA) of Yersinia pestis promotes intracellular survival and virulence in mice. Microb Pathog. 2012;52:41-6 pubmed publisher
    The plague bacterium Yersinia pestis has a number of well-described strategies to protect itself from both host cells and soluble factors...
  67. Salkeld D, Salathé M, Stapp P, Jones J. Plague outbreaks in prairie dog populations explained by percolation thresholds of alternate host abundance. Proc Natl Acad Sci U S A. 2010;107:14247-50 pubmed publisher
    ..In American grasslands, plague, caused by Yersinia pestis, exemplifies this quiescent-outbreak pattern, because it sporadically erupts in epizootics that decimate ..
  68. Li B, Du C, Zhou L, Bi Y, Wang X, Wen L, et al. Humoral and cellular immune responses to Yersinia pestis infection in long-term recovered plague patients. Clin Vaccine Immunol. 2012;19:228-34 pubmed publisher
    Plague is one of the most dangerous diseases and is caused by Yersinia pestis. Effective vaccine development requires understanding of immune protective mechanisms against the bacterium in humans...
  69. Minato Y, Ghosh A, Faulkner W, Lind E, Schesser Bartra S, Plano G, et al. Na+/H+ antiport is essential for Yersinia pestis virulence. Infect Immun. 2013;81:3163-72 pubmed publisher
    ..In this study, we examined the possible role of Na(+)/H(+) antiport in Yersinia pestis virulence and found that Y...
  70. Schotthoefer A, Bearden S, Vetter S, Holmes J, Montenieri J, Graham C, et al. Effects of temperature on early-phase transmission of Yersina pestis by the flea, Xenopsylla cheopis. J Med Entomol. 2011;48:411-7 pubmed
    Sharp declines in human and animal cases of plague, caused by the bacterium Yersinia pestis (Yersin), have been observed when outbreaks coincide with hot weather...
  71. Kwon K, Hasseman J, Latham S, Grose C, Do Y, Fleischmann R, et al. Recombinant expression and functional analysis of proteases from Streptococcus pneumoniae, Bacillus anthracis, and Yersinia pestis. BMC Biochem. 2011;12:17 pubmed publisher
    ..It has been observed that cloning, expression and purification of proteases often fail due to their catalytic functions which, in turn, cause toxicity in the E. coli heterologous host...
  72. Houppert A, Bohman L, Merritt P, Cole C, Caulfield A, Lathem W, et al. RfaL is required for Yersinia pestis type III secretion and virulence. Infect Immun. 2013;81:1186-97 pubmed publisher
    b>Yersinia pestis, the causative agent of plague, uses a type III secretion system (T3SS) to inject cytotoxic Yop proteins directly into the cytosol of mammalian host cells...
  73. Desrosiers D, Bearden S, Mier I, Abney J, Paulley J, Fetherston J, et al. Znu is the predominant zinc importer in Yersinia pestis during in vitro growth but is not essential for virulence. Infect Immun. 2010;78:5163-77 pubmed publisher
    Little is known about Zn homeostasis in Yersinia pestis, the plague bacillus. The Znu ABC transporter is essential for zinc (Zn) uptake and virulence in a number of bacterial pathogens...
  74. Fellows P, Lin W, Detrisac C, Hu S, Rajendran N, Gingras B, et al. Establishment of a Swiss Webster mouse model of pneumonic plague to meet essential data elements under the animal rule. Clin Vaccine Immunol. 2012;19:468-76 pubmed publisher
    ..Standardized procedures for the preparation of Yersinia pestis challenge material also were developed...
  75. Ali R, Naqvi R, Kumar S, Bhat A, Rao D. Multiple antigen peptide containing B and T cell epitopes of F1 antigen of Yersinia pestis showed enhanced Th1 immune response in murine model. Scand J Immunol. 2013;77:361-71 pubmed publisher
    b>Yersinia pestis is a facultative bacterium that can survive and proliferate inside host macrophages and cause bubonic, pneumonic and systemic infection...
  76. Lillo A, Ayriss J, Shou Y, Graves S, Bradbury A, Pavlik P. Development of phage-based single chain Fv antibody reagents for detection of Yersinia pestis. PLoS ONE. 2011;6:e27756 pubmed publisher
    Most Yersinia pestis strains are known to express a capsule-like antigen, fraction 1 (F1)(.) F1 is encoded by the caf1 gene located on the large 100-kb pFra plasmid, which is found in Y...
  77. Koo J, Alleyne T, Schiano C, Jafari N, Lathem W. Global discovery of small RNAs in Yersinia pseudotuberculosis identifies Yersinia-specific small, noncoding RNAs required for virulence. Proc Natl Acad Sci U S A. 2011;108:E709-17 pubmed publisher
    ..Six sRNAs are Y. pseudotuberculosis specific and are absent from the genome of the closely related species Yersinia pestis. We found that the expression of many sRNAs conserved between Y. pseudotuberculosis and Y...
  78. Sun Y, Guo X, Hinnebusch B, Darby C. The Yersinia pestis Rcs phosphorelay inhibits biofilm formation by repressing transcription of the diguanylate cyclase gene hmsT. J Bacteriol. 2012;194:2020-6 pubmed publisher
    b>Yersinia pestis, which causes bubonic plague, forms biofilms in fleas, its insect vectors, as a means to enhance transmission...
  79. Lin J, Park S, Adamovicz J, Hill J, Bliska J, Cote C, et al. TNF? and IFN? contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague. Vaccine. 2010;29:357-62 pubmed publisher
    Immunization with the Yersinia pestis F1 and LcrV proteins improves survival in mouse and non-human primate models of pneumonic plague...
  80. Chauvaux S, Dillies M, Marceau M, Rosso M, Rousseau S, Moszer I, et al. In silico comparison of Yersinia pestis and Yersinia pseudotuberculosis transcriptomes reveals a higher expression level of crucial virulence determinants in the plague bacillus. Int J Med Microbiol. 2011;301:105-16 pubmed publisher
    Although Yersinia pestis and Yersinia pseudotuberculosis are genetically very similar (97% nucleotide sequence identity for most of the chromosomal genes), they exhibit very different patterns of infection. Y...
  81. Dewoody R, Merritt P, Marketon M. YopK controls both rate and fidelity of Yop translocation. Mol Microbiol. 2013;87:301-17 pubmed publisher
    b>Yersinia pestis, the causative agent of plague, utilizes a type III secretion system (T3SS) to intoxicate host cells...
  82. Bahta M, Burke T. Yersinia pestis and approaches to targeting its outer protein H protein-tyrosine phosphatase (YopH). Curr Med Chem. 2012;19:5726-34 pubmed
    ..It remains a threat in many parts of the world today. Plague is caused by the bacterium, Yersinia pestis (Y. pestis), which has as one of its required virulence factors, the protein-tyrosine phosphatase, YopH...
  83. Ye Z, Uittenbogaard A, Cohen D, Kaplan A, Ambati J, Straley S. Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ?yopM mutant in liver and spleen during systemic plague. Infect Immun. 2011;79:674-87 pubmed publisher
    ..to identify the cells and pathways that are undermined by the virulence protein YopM of the plague bacterium Yersinia pestis. In this study, we pursued previous findings that Gr1(+) cells are required to selectively limit growth of ?..
  84. Plesniak L, Mahalakshmi R, Rypien C, Yang Y, Racic J, Marassi F. Expression, refolding, and initial structural characterization of the Y. pestis Ail outer membrane protein in lipids. Biochim Biophys Acta. 2011;1808:482-9 pubmed publisher
    Ail is an outer membrane protein and virulence factor of Yersinia pestis, an extremely pathogenic, category A biothreat agent, responsible for precipitating massive human plague pandemics throughout history...
  85. Yang H, Ke Y, Wang J, Tan Y, Myeni S, Li D, et al. Insight into bacterial virulence mechanisms against host immune response via the Yersinia pestis-human protein-protein interaction network. Infect Immun. 2011;79:4413-24 pubmed publisher
    A Yersinia pestis-human protein interaction network is reported here to improve our understanding of its pathogenesis. Up to 204 interactions between 66 Y...
  86. Wang X, Zhang X, Zhou D, Yang R. Live-attenuated Yersinia pestis vaccines. Expert Rev Vaccines. 2013;12:677-86 pubmed publisher
    Plague caused by Yersinia pestis is one of the most dangerous infectious diseases...
  87. Nham T, Filali S, Danne C, Derbise A, Carniel E. Imaging of bubonic plague dynamics by in vivo tracking of bioluminescent Yersinia pestis. PLoS ONE. 2012;7:e34714 pubmed publisher
    b>Yersinia pestis dissemination in a host is usually studied by enumerating bacteria in the tissues of animals sacrificed at different times...
  88. Fetherston J, Mier I, Truszczynska H, Perry R. The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plague. Infect Immun. 2012;80:3880-91 pubmed publisher
    The Yfe/Sit and Feo transport systems are important for the growth of a variety of bacteria. In Yersinia pestis, single mutations in either yfe or feo result in reduced growth under static (limited aeration), iron-chelated conditions, ..
  89. Schotthoefer A, Bearden S, Holmes J, Vetter S, Montenieri J, Williams S, et al. Effects of temperature on the transmission of Yersinia Pestis by the flea, Xenopsylla Cheopis, in the late phase period. Parasit Vectors. 2011;4:191 pubmed publisher
    Traditionally, efficient flea-borne transmission of Yersinia pestis, the causative agent of plague, was thought to be dependent on a process referred to as blockage in which biofilm-mediated growth of the bacteria physically blocks the ..
  90. Tsang T, Felek S, Krukonis E. Ail binding to fibronectin facilitates Yersinia pestis binding to host cells and Yop delivery. Infect Immun. 2010;78:3358-68 pubmed publisher
    b>Yersinia pestis, the causative agent of plague, evades host immune responses and rapidly causes disease. The Y. pestis adhesin Ail mediates host cell binding and is critical for Yop delivery...
  91. Kolodziejek A, Hovde C, Minnich S. Yersinia pestis Ail: multiple roles of a single protein. Front Cell Infect Microbiol. 2012;2:103 pubmed publisher
    b>Yersinia pestis is one of the most virulent bacteria identified. It is the causative agent of plague-a systemic disease that has claimed millions of human lives throughout history. Y...