proteus mirabilis

Summary

Summary: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is frequently isolated from clinical specimens. Its most common site of infection is the urinary tract.

Top Publications

  1. Saito R, Sato K, Kumita W, Inami N, Nishiyama H, Okamura N, et al. Role of type II topoisomerase mutations and AcrAB efflux pump in fluoroquinolone-resistant clinical isolates of Proteus mirabilis. J Antimicrob Chemother. 2006;58:673-7 pubmed
    We conducted a study to determine the role played by amino acid mutations in DNA gyrase and topoisomerase IV, and the AcrAB efflux pump in resistance to fluoroquinolones in clinical isolates of Proteus mirabilis.
  2. Schadich E, Cole A. Pathogenicity of Aeromonas hydrophila, Klebsiella pneumoniae, and Proteus mirabilis to brown tree frogs (Litoria ewingii). Comp Med. 2010;60:114-7 pubmed
    ..Chryseobacterium indologenes, Chryseobacterium meningosepticum, Citrobacter freundii, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Serratia liquifaciens...
  3. Rocha S, Elias W, Cianciarullo A, Menezes M, Nara J, Piazza R, et al. Aggregative adherence of uropathogenic Proteus mirabilis to cultured epithelial cells. FEMS Immunol Med Microbiol. 2007;51:319-26 pubmed
    b>Proteus mirabilis is an important cause of urinary tract infection (UTI) in patients with complicated urinary tracts. Thirty-five strains of P. mirabilis isolated from UTI were examined for the adherence capacity to epithelial cells...
  4. Lee Y, Patellis J, Belas R. Activity of Proteus mirabilis FliL is viscosity dependent and requires extragenic DNA. J Bacteriol. 2013;195:823-32 pubmed publisher
    b>Proteus mirabilis is a urinary tract pathogen and well known for its ability to move over agar surfaces by flagellum-dependent swarming motility. When P. mirabilis encounters a highly viscous environment, e.g...
  5. Jones S, Yerly J, Hu Y, Ceri H, Martinuzzi R. Structure of Proteus mirabilis biofilms grown in artificial urine and standard laboratory media. FEMS Microbiol Lett. 2007;268:16-21 pubmed
    b>Proteus mirabilis is a urinary pathogen that can differentiate from a swimmer cell into a swarmer cell morphotype and can form biofilms on the surfaces of urinary catheters...
  6. Rocha S, Pelayo J, Elias W. Fimbriae of uropathogenic Proteus mirabilis. FEMS Immunol Med Microbiol. 2007;51:1-7 pubmed
    b>Proteus mirabilis is a common causative agent of cystitis and pyelonephritis in patients with urinary catheters or structural abnormalities of the urinary tract...
  7. Morgenstein R, Szostek B, Rather P. Regulation of gene expression during swarmer cell differentiation in Proteus mirabilis. FEMS Microbiol Rev. 2010;34:753-63 pubmed publisher
    The gram-negative bacterium Proteus mirabilis can exist in either of two cell types, a vegetative cell characterized as a short rod and a highly elongated and hyperflagellated swarmer cell...
  8. Jiang S, Liu M, Teng L, Wang W, Hsueh P, Liaw S. Proteus mirabilis pmrI, an RppA-regulated gene necessary for polymyxin B resistance, biofilm formation, and urothelial cell invasion. Antimicrob Agents Chemother. 2010;54:1564-71 pubmed publisher
    b>Proteus mirabilis is naturally resistant to polymyxin B (PB). To investigate the underlying mechanisms, Tn5 mutagenesis was performed, and a mutant exhibiting increased PB susceptibility was isolated...
  9. Clemmer K, Rather P. The Lon protease regulates swarming motility and virulence gene expression in Proteus mirabilis. J Med Microbiol. 2008;57:931-7 pubmed publisher
    ..insertion in a gene encoding an orthologue of the Lon protease conferred a hyper-swarming phenotype on Proteus mirabilis. The lon mutation increased the accumulation of mRNA for representative class 1 (flhDC), class 2 (fliA) and ..

More Information

Publications93

  1. Ma Q, Fonseca A, Liu W, Fields A, Pimsler M, Spindola A, et al. Proteus mirabilis interkingdom swarming signals attract blow flies. ISME J. 2012;6:1356-66 pubmed publisher
    ..Our hypothesis was that this symbiotic interaction may depend on interkingdom signaling. We obtained Proteus mirabilis from the salivary glands of the blow fly Lucilia sericata; this strain swarmed significantly and produced a ..
  2. Treviño M, Navarro D, Barbeito G, Areses P, García Riestra C, Regueiro B. [Plasmid-mediated AMPc producing Proteus mirabilis in the Health Care Area of Santiago de Compostela: molecular and epidemiological analysis by rep-PCR and MALDI-TOF]. Rev Esp Quimioter. 2012;25:122-8 pubmed
    b>Proteus mirabilis is an important pathogen isolated from both community-acquired and health-care associated infections...
  3. Wu J, Chen H, Ko W, Wu H, Tsai S, Yan J. Prevalence of extended-spectrum beta-lactamases in Proteus mirabilis in a Taiwanese university hospital, 1999 to 2005: identification of a novel CTX-M enzyme (CTX-M-66). Diagn Microbiol Infect Dis. 2008;60:169-75 pubmed
    A total of 1574 nonduplicate Proteus mirabilis isolates collected at a Taiwanese hospital during 1999 to 2005 were analyzed for production of extended-spectrum beta-lactamases (ESBLs)...
  4. Gibbs K, Urbanowski M, Greenberg E. Genetic determinants of self identity and social recognition in bacteria. Science. 2008;321:256-9 pubmed publisher
    The bacterium Proteus mirabilis is capable of movement on solid surfaces by a type of motility called swarming. Boundaries form between swarming colonies of different P. mirabilis strains but not between colonies of a single strain...
  5. Morgenstein R, Clemmer K, Rather P. Loss of the waaL O-antigen ligase prevents surface activation of the flagellar gene cascade in Proteus mirabilis. J Bacteriol. 2010;192:3213-21 pubmed publisher
    b>Proteus mirabilis is a Gram-negative bacterium that undergoes a physical and biochemical change from a vegetative swimmer cell (a typical Gram-negative rod) to an elongated swarmer cell when grown on a solid surface...
  6. Jebamercy G, Balamurugan K. Effects of sequential infections of Caenorhabditis elegans with Staphylococcus aureus and Proteus mirabilis. Microbiol Immunol. 2012;56:825-35 pubmed publisher
    ..With C. elegans, Proteus mirabilis acts as an opportunistic pathogen and does not kill this host. Hence, in the present study, C...
  7. Lautenbach E, Marsicano R, Tolomeo P, Heard M, Serrano S, Stieritz D. Epidemiology of antimicrobial resistance among gram-negative organisms recovered from patients in a multistate network of long-term care facilities. Infect Control Hosp Epidemiol. 2009;30:790-3 pubmed publisher
    ..The prevalence of resistance varied significantly by facility type, size, and geographic location...
  8. Armbruster C, Smith S, Yep A, Mobley H. Increased incidence of urolithiasis and bacteremia during Proteus mirabilis and Providencia stuartii coinfection due to synergistic induction of urease activity. J Infect Dis. 2014;209:1524-32 pubmed publisher
    ..The urease-positive species Proteus mirabilis and Providencia stuartii are two of the leading causes of CaUTIs and commonly co-colonize catheters...
  9. Jiang S, Lin T, Wang W, Liu M, Hsueh P, Liaw S. Characterization of UDP-glucose dehydrogenase and UDP-glucose pyrophosphorylase mutants of Proteus mirabilis: defectiveness in polymyxin B resistance, swarming, and virulence. Antimicrob Agents Chemother. 2010;54:2000-9 pubmed publisher
    b>Proteus mirabilis is known to be highly resistant to the action of polymyxin B (PB). However, the mechanism underlying PB resistance is not clear...
  10. Pearson M, Yep A, Smith S, Mobley H. Transcriptome of Proteus mirabilis in the murine urinary tract: virulence and nitrogen assimilation gene expression. Infect Immun. 2011;79:2619-31 pubmed publisher
    The enteric bacterium Proteus mirabilis is a common cause of complicated urinary tract infections. In this study, microarrays were used to analyze P. mirabilis gene expression in vivo from experimentally infected mice...
  11. Irwin N, McCoy C, Carson L. Effect of pH on the in vitro susceptibility of planktonic and biofilm-grown Proteus mirabilis to the quinolone antimicrobials. J Appl Microbiol. 2013;115:382-9 pubmed publisher
    ..as reported during urinary catheter infections, on quinolone activity against the urease-producing pathogen Proteus mirabilis. Susceptibility of Pr...
  12. Budding A, Ingham C, Bitter W, Vandenbroucke Grauls C, Schneeberger P. The Dienes phenomenon: competition and territoriality in Swarming Proteus mirabilis. J Bacteriol. 2009;191:3892-900 pubmed publisher
    When two different strains of swarming Proteus mirabilis encounter one another on an agar plate, swarming ceases and a visible line of demarcation forms...
  13. Siebor E, Neuwirth C. The new variant of Salmonella genomic island 1 (SGI1-V) from a Proteus mirabilis French clinical isolate harbours blaVEB-6 and qnrA1 in the multiple antibiotic resistance region. J Antimicrob Chemother. 2011;66:2513-20 pubmed publisher
    The clinical strain of Proteus mirabilis VB1248 isolated from a blood culture in August 2009 was multiresistant (i.e. resistant to ?-lactams, fluoroquinolones, aminoglycosides and sulphonamides)...
  14. Phan V, Belas R, Gilmore B, Ceri H. ZapA, a virulence factor in a rat model of Proteus mirabilis-induced acute and chronic prostatitis. Infect Immun. 2008;76:4859-64 pubmed publisher
    ..To determine the role of the virulence factor ZapA, a 54-kDa metalloproteinase of Proteus mirabilis, in prostatitis, rats were infected with either wild-type (WT) P...
  15. Nielubowicz G, Smith S, Mobley H. Zinc uptake contributes to motility and provides a competitive advantage to Proteus mirabilis during experimental urinary tract infection. Infect Immun. 2010;78:2823-33 pubmed publisher
    b>Proteus mirabilis, a Gram-negative bacterium, represents a common cause of complicated urinary tract infections in catheterized patients or those with functional or anatomical abnormalities of the urinary tract...
  16. Pitout J, Le P, Moore K, Church D, Gregson D. Detection of AmpC beta-lactamases in Escherichia coli, Klebsiella spp., Salmonella spp. and Proteus mirabilis in a regional clinical microbiology laboratory. Clin Microbiol Infect. 2010;16:165-70 pubmed publisher
    ..Escherichia coli, Proteus mirabilis and Salmonella spp...
  17. Pearson M, Mobley H. The type III secretion system of Proteus mirabilis HI4320 does not contribute to virulence in the mouse model of ascending urinary tract infection. J Med Microbiol. 2007;56:1277-83 pubmed
    The Gram-negative enteric bacterium Proteus mirabilis is a frequent cause of urinary tract infections (UTIs) in individuals with long-term indwelling catheters or with complicated urinary tracts. The recent release of the P...
  18. Choi K, Schweizer H. mini-Tn7 insertion in bacteria with secondary, non-glmS-linked attTn7 sites: example Proteus mirabilis HI4320. Nat Protoc. 2006;1:170-8 pubmed
    ..Here we provide a protocol for application of the mini-Tn7 system in Proteus mirabilis as an example of a bacterium with a secondary attTn7 site that is not linked to glmS but, in this case, ..
  19. O May G, Jacobsen S, Longwell M, Stoodley P, Mobley H, Shirtliff M. The high-affinity phosphate transporter Pst in Proteus mirabilis HI4320 and its importance in biofilm formation. Microbiology. 2009;155:1523-35 pubmed publisher
    b>Proteus mirabilis causes urinary tract infections (UTIs) in individuals requiring long-term indwelling catheterization...
  20. Cohen Nahum K, Saidel Odes L, Riesenberg K, Schlaeffer F, Borer A. Urinary tract infections caused by multi-drug resistant Proteus mirabilis: Risk factors and clinical outcomes. Infection. 2010;38:41-6 pubmed publisher
    b>Proteus mirabilis (PM) as well as other members of the Enterobacteriaceae family are a leading cause of infectious diseases in both the community and acute care settings...
  21. Mokracka J, Gruszczyńska B, Kaznowski A. Integrons, ?-lactamase and qnr genes in multidrug resistant clinical isolates of Proteus mirabilis and P. vulgaris. APMIS. 2012;120:950-8 pubmed publisher
    Thirty-three isolates of Proteus mirabilis and two P...
  22. Raffi H, Bates J, Laszik Z, Kumar S. Tamm-horsfall protein protects against urinary tract infection by proteus mirabilis. J Urol. 2009;181:2332-8 pubmed publisher
    b>Proteus mirabilis is a common cause of urinary tract infection. We determined the role of Tamm-Horsfall protein as a host defense factor against the cystitis and pyelonephritis caused by P. mirabilis...
  23. Perepelov A, Zabłotni A, Shashkov A, Knirel Y, Sidorczyk Z. Structure of the O-polysaccharide of Proteus mirabilis CCUG 10705 (OF) containing an amide of D-galacturonic acid with L-alanine. Carbohydr Res. 2006;341:1969-74 pubmed
    The structure of the O-polysaccharide of Proteus mirabilis CCUG 10705 (OF) was determined by chemical analyses along with one- and two-dimensional (1)H and (13)C NMR spectroscopy...
  24. Lee W, Jung B, Hong S, Song W, Jeong S, Lee K, et al. Comparison of 3 phenotypic-detection methods for identifying plasmid-mediated AmpC beta-lactamase-producing Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis strains. Korean J Lab Med. 2009;29:448-54 pubmed publisher
    ..b>Proteus mirabilis, and Salmonella spp...
  25. Samadi N, Golkaran D, Eslamifar A, Jamalifar H, Fazeli M, Mohseni F. Intra/extracellular biosynthesis of silver nanoparticles by an autochthonous strain of Proteus mirabilis isolated from photographic waste. J Biomed Nanotechnol. 2009;5:247-53 pubmed
    ..of an efficient and eco-friendly viable process for the synthesis of nanoscale silver particles using Proteus mirabilis PTCC 1710, a bacterial strain that was isolated during a screening program from photographic waste...
  26. Alamuri P, Mobley H. A novel autotransporter of uropathogenic Proteus mirabilis is both a cytotoxin and an agglutinin. Mol Microbiol. 2008;68:997-1017 pubmed publisher
    One of the six predicted Proteus mirabilis autotransporters (ATs), ORF c2341, is predicted to contain a serine protease motif and was earlier identified as an immunogenic outer membrane protein in P. mirabilis. The 3...
  27. Kanayama A, Iyoda T, Matsuzaki K, Saika T, Ikeda F, Ishii Y, et al. Rapidly spreading CTX-M-type beta-lactamase-producing Proteus mirabilis in Japan. Int J Antimicrob Agents. 2010;36:340-2 pubmed publisher
    In recent years, increased isolation of extended-spectrum beta-lactamase (ESBL)-producing Proteus mirabilis has been reported in Japan. We undertook an investigation to determine the prevalence of ESBL-producing P...
  28. Schulze S, Köster S, Geldmacher U, Terwisscha van Scheltinga A, Kuhlbrandt W. Structural basis of Na(+)-independent and cooperative substrate/product antiport in CaiT. Nature. 2010;467:233-6 pubmed publisher
    ..Here we report the structures of the sodium-independent carnitine/butyrobetaine antiporter CaiT from Proteus mirabilis (PmCaiT) at 2.3-A and from Escherichia coli (EcCaiT) at 3.5-A resolution...
  29. D Andrea M, Literacka E, Zioga A, Giani T, Baraniak A, Fiett J, et al. Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe. Antimicrob Agents Chemother. 2011;55:2735-42 pubmed publisher
    b>Proteus mirabilis isolates obtained in 1999 to 2008 from three European countries were analyzed; all carried chromosomal AmpC-type cephalosporinase bla(CMY) genes from a Citrobacter freundii origin (bla(CMY-2)-like genes)...
  30. Armbruster C, Mobley H. Merging mythology and morphology: the multifaceted lifestyle of Proteus mirabilis. Nat Rev Microbiol. 2012;10:743-54 pubmed publisher
    b>Proteus mirabilis, named for the Greek god who changed shape to avoid capture, has fascinated microbiologists for more than a century with its unique swarming differentiation, Dienes line formation and potent urease activity...
  31. Tuson H, Copeland M, Carey S, Sacotte R, Weibel D. Flagellum density regulates Proteus mirabilis swarmer cell motility in viscous environments. J Bacteriol. 2013;195:368-77 pubmed publisher
    b>Proteus mirabilis is an opportunistic pathogen that is frequently associated with urinary tract infections. In the lab, P...
  32. Lane M, Li X, Pearson M, Simms A, Mobley H. Oxygen-limiting conditions enrich for fimbriate cells of uropathogenic Proteus mirabilis and Escherichia coli. J Bacteriol. 2009;191:1382-92 pubmed publisher
    MR/P fimbriae of uropathogenic Proteus mirabilis undergo invertible element-mediated phase variation whereby an individual bacterium switches between expressing fimbriae (phase ON) and not expressing fimbriae (phase OFF)...
  33. Stankowska D, Kwinkowski M, Kaca W. Quantification of Proteus mirabilis virulence factors and modulation by acylated homoserine lactones. J Microbiol Immunol Infect. 2008;41:243-53 pubmed
    Measurement of the main Proteus mirabilis virulence factors would increase our understanding of how the organism infects and colonizes the urinary tract. The purpose of this study was to quantify the virulence factors of twelve P...
  34. Callewaert L, Vanderkelen L, Deckers D, Aertsen A, Robben J, Michiels C. Detection of a lysozyme inhibitor in Proteus mirabilis by a new reverse zymogram method. Appl Environ Microbiol. 2008;74:4978-81 pubmed publisher
    ..This method was validated by using a periplasmic protein extract of Escherichia coli containing a known inhibitor and subsequently led to the detection of a new proteinaceous hen egg white lysozyme inhibitor in Proteus mirabilis.
  35. Vourli S, Tsorlini H, Katsifa H, Polemis M, Tzouvelekis L, Kontodimou A, et al. Emergence of Proteus mirabilis carrying the bla metallo-beta-lactamase gene. Clin Microbiol Infect. 2006;12:691-4 pubmed
    Seven genetically related Proteus mirabilis clinical isolates from a hospital in Thessaloniki, Greece, exhibited decreased susceptibility to imipenem and carried a bla(VIM-1) metallo-beta-lactamase gene...
  36. Mazzariol A, Kocsis B, Koncan R, Kocsis E, Lanzafame P, Cornaglia G. Description and plasmid characterization of qnrD determinants in Proteus mirabilis and Morganella morganii. Clin Microbiol Infect. 2012;18:E46-8 pubmed publisher
    ..Four Proteus mirabilis and one Morganella morganii (0...
  37. Tibbetts R, Frye J, Marschall J, Warren D, Dunne W. Detection of KPC-2 in a clinical isolate of Proteus mirabilis and first reported description of carbapenemase resistance caused by a KPC beta-lactamase in P. mirabilis. J Clin Microbiol. 2008;46:3080-3 pubmed publisher
    An isolate of Proteus mirabilis recovered from blood cultures of a diabetic patient was shown to be resistant to imipenem, meropenem, and ertapenem by disk diffusion susceptibility testing...
  38. Federici L, Masulli M, Di Ilio C, Allocati N. Characterization of the hydrophobic substrate-binding site of the bacterial beta class glutathione transferase from Proteus mirabilis. Protein Eng Des Sel. 2010;23:743-50 pubmed publisher
    ..by site-directed mutagenesis of residues facing the H-site in the bacterial beta class GSH transferase from Proteus mirabilis. We investigate the behaviour of these mutants under a variety of conditions and analyse their activity ..
  39. Xia S, Zhang Z, Wang X, Yang A, Chen L, Zhao J, et al. Production and characterization of a bioflocculant by Proteus mirabilis TJ-1. Bioresour Technol. 2008;99:6520-7 pubmed
    ..By 16S rDNA sequence and biochemical and physiological characteristics, strain TJ-1 was identified as Proteus mirabilis. The most preferred carbon source, nitrogen source and C/N ratio (w/w) for strain TJ-1 to produce the ..
  40. Carpinella M, De Bellis L, Joray M, Sosa V, Zunino P, Palacios S. Inhibition of development, swarming differentiation and virulence factors in Proteus mirabilis by an extract of Lithrea molleoides and its active principle (Z,Z)-5-(trideca-4',7'-dienyl)-resorcinol. Phytomedicine. 2011;18:994-7 pubmed publisher
    Antibacterial activity of Lithrea molleoides extract against Proteus mirabilis has been previously reported by our group...
  41. Boyd D, Shi X, Hu Q, Ng L, Doublet B, Cloeckaert A, et al. Salmonella genomic island 1 (SGI1), variant SGI1-I, and new variant SGI1-O in proteus mirabilis clinical and food isolates from China. Antimicrob Agents Chemother. 2008;52:340-4 pubmed
    ..genomic island 1 (SGI1) and variants (SGI1-I and the new variant SGI1-O) were mapped in five strains of Proteus mirabilis isolated from humans and food in China...
  42. Morrissey I, Bouchillon S, Hackel M, Biedenbach D, Hawser S, Hoban D, et al. Evaluation of the Clinical and Laboratory Standards Institute phenotypic confirmatory test to detect the presence of extended-spectrum ?-lactamases from 4005 Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae and Proteus mirabilis isolates. J Med Microbiol. 2014;63:556-61 pubmed publisher
    A subset of Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae and Proteus mirabilis isolates collected for the Study for Monitoring Antimicrobial Resistance Trends that were positive for the Clinical and Laboratory Standards ..
  43. Galani I, Souli M, Koratzanis E, Koratzanis G, Chryssouli Z, Giamarellou H. Emerging bacterial pathogens: Escherichia coli, Enterobacter aerogenes and Proteus mirabilis clinical isolates harbouring the same transferable plasmid coding for metallo-beta-lactamase VIM-1 in Greece. J Antimicrob Chemother. 2007;59:578-9 pubmed
  44. Kuan L, Schaffer J, Zouzias C, Pearson M. Characterization of 17 chaperone-usher fimbriae encoded by Proteus mirabilis reveals strong conservation. J Med Microbiol. 2014;63:911-22 pubmed publisher
    b>Proteus mirabilis is a Gram-negative enteric bacterium that causes complicated urinary tract infections, particularly in patients with indwelling catheters. Sequencing of clinical isolate P...
  45. Hu Y, Cai J, Zhang R, Zhou H, Sun Q, Chen G. Emergence of Proteus mirabilis harboring blaKPC-2 and qnrD in a Chinese Hospital. Antimicrob Agents Chemother. 2012;56:2278-82 pubmed publisher
    Nineteen carbapenem-nonsusceptible Proteus mirabilis isolates were recovered from intensive care units in the Second Affiliated Hospital of Zhejiang University during a 3-month period...
  46. Song W, Kim J, Bae I, Jeong S, Seo Y, Shin J, et al. Chromosome-encoded AmpC and CTX-M extended-spectrum ?-lactamases in clinical isolates of Proteus mirabilis from Korea. Antimicrob Agents Chemother. 2011;55:1414-9 pubmed publisher
    Among 222 Proteus mirabilis clinical isolates collected from 17 hospitals in Korea in 2008, 28 (12.6%) and 8 (3.6%) isolates exhibited extended-spectrum ?-lactamase (ESBL) and AmpC phenotypes, respectively...
  47. Wang M, Guo Q, Xu X, Wang X, Ye X, Wu S, et al. New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Antimicrob Agents Chemother. 2009;53:1892-7 pubmed publisher
    ..A clinical strain of Proteus mirabilis was isolated from an outpatient with a urinary tract infection and was susceptible to most antimicrobials ..
  48. Sosa V, Schlapp G, Zunino P. Proteus mirabilis isolates of different origins do not show correlation with virulence attributes and can colonize the urinary tract of mice. Microbiology. 2006;152:2149-57 pubmed
    b>Proteus mirabilis has been described as an aetiological agent in a wide range of infections, playing an important role in urinary tract infections (UTIs). In this study, a collection of P...
  49. Chong Y, Shimoda S, Yakushiji H, Ito Y, Miyamoto T, Kamimura T, et al. Community spread of extended-spectrum ?-lactamase-producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis: a long-term study in Japan. J Med Microbiol. 2013;62:1038-43 pubmed publisher
    ..Out of 5137 isolates, 321 (6.3?%) were ESBL producers, including E. coli, Klebsiella pneumoniae and Proteus mirabilis. The detection rates of the ESBL-producing isolates gradually increased and reached 14.3, 8.7 and 19...
  50. Keirsse J, Lahaye E, Bouter A, Dupont V, Boussard Pledel C, Bureau B, et al. Mapping bacterial surface population physiology in real-time: infrared spectroscopy of Proteus mirabilis swarm colonies. Appl Spectrosc. 2006;60:584-91 pubmed
    We mapped the space-time distribution of stationary and swarmer cells within a growing Proteus mirabilis colony by infrared (IR) microspectroscopy...
  51. Vinogradov E. Structure of the core part of the lipopolysaccharide from Proteus mirabilis genomic strain HI4320. Biochemistry (Mosc). 2011;76:803-7 pubmed publisher
    The structure of the core part of the lipopolysaccharide from Proteus mirabilis genomic strain HI4320 was studied...
  52. Jacobsen S, Shirtliff M. Proteus mirabilis biofilms and catheter-associated urinary tract infections. Virulence. 2011;2:460-5 pubmed publisher
    b>Proteus mirabilis inhabits the environment and causes a number of infections including those of the skin, respiratory tract, wounds and urinary tract...
  53. Flannery E, Antczak S, Mobley H. Self-transmissibility of the integrative and conjugative element ICEPm1 between clinical isolates requires a functional integrase, relaxase, and type IV secretion system. J Bacteriol. 2011;193:4104-12 pubmed publisher
    ..Recently, we identified a genomic island of Proteus mirabilis, a common agent of catheter-associated urinary tract infection (UTI), that possesses all the properties ..
  54. Doublet B, Golding G, Mulvey M, Cloeckaert A. Potential integration sites of the Salmonella genomic island 1 in Proteus mirabilis and other bacteria. J Antimicrob Chemother. 2007;59:801-3 pubmed
  55. Luzzaro F, Brigante G, D Andrea M, Pini B, Giani T, Mantengoli E, et al. Spread of multidrug-resistant Proteus mirabilis isolates producing an AmpC-type beta-lactamase: epidemiology and clinical management. Int J Antimicrob Agents. 2009;33:328-33 pubmed publisher
    A remarkable increase in Proteus mirabilis strains producing acquired AmpC-type beta-lactamases (CBLs) has been observed at Ospedale di Circolo e Fondazione Macchi (Varese, Italy) over the last few years...
  56. Wang W, Lai H, Hsueh P, Chiou R, Lin S, Liaw S. Inhibition of swarming and virulence factor expression in Proteus mirabilis by resveratrol. J Med Microbiol. 2006;55:1313-21 pubmed
    ..The effect of resveratrol on swarming and virulence factor expression of Proteus mirabilis, an important pathogen infecting the urinary tract, was determined on swarming agar plates with and without ..
  57. Lima A, Zunino P, D Alessandro B, Piccini C. An iron-regulated outer-membrane protein of Proteus mirabilis is a haem receptor that plays an important role in urinary tract infection and in in vivo growth. J Med Microbiol. 2007;56:1600-7 pubmed
    b>Proteus mirabilis, a common cause of urinary tract infections, expresses iron-regulated outer-membrane proteins (OMPs) in response to iron restriction...
  58. Hammer M, Brauser A, Olak C, Brezesinski G, Goldmann T, Gutsmann T, et al. Lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide NK-2 against Escherichia coli and Proteus mirabilis. Biochem J. 2010;427:477-88 pubmed publisher
    ..study we investigated interactions of NK-2 and a shortened variant with viable Escherichia coli WBB01 and Proteus mirabilis R45, and with model membranes composed of LPS isolated from these two strains...
  59. Stickler D, Jones G. Reduced Susceptibility of Proteus mirabilis to triclosan. Antimicrob Agents Chemother. 2008;52:991-4 pubmed publisher
    Clinical isolates of Proteus mirabilis causing catheter encrustation and blockage are susceptible to the biocide triclosan (MICs of 0.2 mg/liter)...
  60. Cusick K, Lee Y, Youchak B, Belas R. Perturbation of FliL interferes with Proteus mirabilis swarmer cell gene expression and differentiation. J Bacteriol. 2012;194:437-47 pubmed publisher
    b>Proteus mirabilis is a dimorphic, motile bacterium often associated with urinary tract infections...
  61. Wang W, Chen I, Jiang S, Chen H, Hsu C, Hsueh P, et al. Role of RppA in the regulation of polymyxin b susceptibility, swarming, and virulence factor expression in Proteus mirabilis. Infect Immun. 2008;76:2051-62 pubmed publisher
    b>Proteus mirabilis, a human pathogen that frequently causes urinary tract infections, is intrinsically highly resistant to cationic antimicrobial peptides, such as polymyxin B (PB). To explore the mechanisms underlying P...
  62. Cui G, Zhong S, Yang S, Zuo X, Liang M, Sun J, et al. Effects of Taishan Pinus massoniana pollen polysaccharide on the subunit vaccine of Proteus mirabilis in birds. Int J Biol Macromol. 2013;56:94-8 pubmed publisher
    ..TPPPS), white mineral oil (WO) and propolis (PP), were added to the outer membrane protein (OMP) of Proteus mirabilis (P. mirabilis) and their effects were compared...
  63. Arabski M, Wasik S, Dworecki K, Kaca W. Laser interferometric and cultivation methods for measurement of colistin/ampicilin and saponin interactions with smooth and rough of Proteus mirabilis lipopolysaccharides and cells. J Microbiol Methods. 2009;77:178-83 pubmed publisher
    ..The modification relies on the measurement of diffusion from 1% agarose gel. As a model for this study, two Proteus mirabilis strains were used that differ in polysaccharide content: smooth P...
  64. Pearson M, Mobley H. Repression of motility during fimbrial expression: identification of 14 mrpJ gene paralogues in Proteus mirabilis. Mol Microbiol. 2008;69:548-58 pubmed
    b>Proteus mirabilis alternates between motile and adherent forms. MrpJ, a transcriptional regulator previously reported to repress motility, is encoded at the 3' end of the mrp fimbrial operon in P. mirabilis. Sequencing of the P...
  65. Aiassa V, Barnes A, Albesa I. Resistance to ciprofloxacin by enhancement of antioxidant defenses in biofilm and planktonic Proteus mirabilis. Biochem Biophys Res Commun. 2010;393:84-8 pubmed publisher
    Antibiotic resistance and antioxidant defense were induced by ciprofloxacin in planktonic Proteus mirabilis and compared with the natural antibiotic resistance of biofilm...
  66. Saito R, Okugawa S, Kumita W, Sato K, Chida T, Okamura N, et al. Clinical epidemiology of ciprofloxacin-resistant Proteus mirabilis isolated from urine samples of hospitalised patients. Clin Microbiol Infect. 2007;13:1204-6 pubmed
    This study investigated the clinical characteristics of ciprofloxacin-resistant Proteus mirabilis isolates from urine samples associated with nosocomial infection or colonisation, and identified the risk-factors for ciprofloxacin ..
  67. Hossain G, Li J, Shin H, Chen R, Du G, Liu L, et al. Bioconversion of l-glutamic acid to ?-ketoglutaric acid by an immobilized whole-cell biocatalyst expressing l-amino acid deaminase from Proteus mirabilis. J Biotechnol. 2014;169:112-20 pubmed publisher
    ..mirabilisl-AAD. Compared with traditional multistep chemical synthesis, the biocatalytic process described here has the advantage of reducing environmental pollution and thus has great potential for the large-scale production of ?-KG. ..
  68. Alamuri P, Löwer M, Hiss J, Himpsl S, Schneider G, Mobley H. Adhesion, invasion, and agglutination mediated by two trimeric autotransporters in the human uropathogen Proteus mirabilis. Infect Immun. 2010;78:4882-94 pubmed publisher
    Fimbriae of the human uropathogen Proteus mirabilis are the only characterized surface proteins that contribute to its virulence by mediating adhesion and invasion of the uroepithelia...
  69. Holling N, Lednor D, Tsang S, Bissell A, Campbell L, Nzakizwanayo J, et al. Elucidating the genetic basis of crystalline biofilm formation in Proteus mirabilis. Infect Immun. 2014;82:1616-26 pubmed publisher
    b>Proteus mirabilis forms extensive crystalline biofilms on urethral catheters that occlude urine flow and frequently complicate the management of long-term-catheterized patients...
  70. Aquilini E, Azevedo J, Jimenez N, Bouamama L, Tomas J, Regue M. Functional identification of the Proteus mirabilis core lipopolysaccharide biosynthesis genes. J Bacteriol. 2010;192:4413-24 pubmed publisher
    ..of genes required for the biosynthesis of the core lipopolysaccharides (LPSs) of two strains of Proteus mirabilis. Since P...
  71. Weaver T, Smith J, Hocking J, Bailey L, Wawrzyn G, Howard D, et al. Structural and functional studies of truncated hemolysin A from Proteus mirabilis. J Biol Chem. 2009;284:22297-309 pubmed publisher
    In this study we analyzed the structure and function of a truncated form of hemolysin A (HpmA265) from Proteus mirabilis using a series of functional and structural studies. Hemolysin A belongs to the two-partner secretion pathway...
  72. Nakano R, Nakano A, Abe M, Inoue M, Okamoto R. Regional outbreak of CTX-M-2 ?-lactamase-producing Proteus mirabilis in Japan. J Med Microbiol. 2012;61:1727-35 pubmed publisher
    b>Proteus mirabilis is a common cause of urinary tract infection. Wild-type P. mirabilis strains are usually susceptible to penicillins and cephalosporins, but occurrences of P...
  73. Prywer J, Torzewska A, Płociński T. Unique surface and internal structure of struvite crystals formed by Proteus mirabilis. Urol Res. 2012;40:699-707 pubmed publisher
    Crystallization of struvite from artificial urine in the presence of Proteus mirabilis microorganisms depends strongly on pH value. At small value of pH, struvite yields crystals of coffin-like habit with very specific structure...
  74. Pearson M, Sebaihia M, Churcher C, Quail M, Seshasayee A, Luscombe N, et al. Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility. J Bacteriol. 2008;190:4027-37 pubmed publisher
    The gram-negative enteric bacterium Proteus mirabilis is a frequent cause of urinary tract infections in individuals with long-term indwelling catheters or with complicated urinary tracts (e.g...
  75. Aragón L, Mirelis B, Miro E, Mata C, Gomez L, Rivera A, et al. Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases. J Antimicrob Chemother. 2008;61:1029-32 pubmed publisher
    ..the different inhibitor-resistant TEM beta-lactamases, extended-spectrum beta-lactamases (ESBLs) and plasmid-mediated AmpC beta-lactamases implicated in beta-lactam resistance in Proteus mirabilis, which has increased over recent years.
  76. Scavone P, Umpierrez A, Maskell D, Zunino P. Nasal immunization with attenuated Salmonella Typhimurium expressing an MrpA-TetC fusion protein significantly reduces Proteus mirabilis colonization in the mouse urinary tract. J Med Microbiol. 2011;60:899-904 pubmed publisher
    ..b>Proteus mirabilis is commonly associated with complicated UTIs and expresses several virulence factors, including mannose-..
  77. Tan T, Ng S, Teo L, Koh Y, Teok C. Detection of plasmid-mediated AmpC in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. J Clin Pathol. 2008;61:642-4 pubmed
    ..plasmid-mediated AmpC production in selected clinical isolates of Escherichia coli, Klebsiella species and Proteus mirabilis, and compared the results of boronic acid disc screening with conventional susceptibility testing for the ..
  78. Stickler D, Morgan S. Modulation of crystalline Proteus mirabilis biofilm development on urinary catheters. J Med Microbiol. 2006;55:489-94 pubmed
    The crystalline biofilms formed by Proteus mirabilis can seriously complicate the care of patients undergoing long-term bladder catheterization...
  79. Carson L, Gorman S, Gilmore B. The use of lytic bacteriophages in the prevention and eradication of biofilms of Proteus mirabilis and Escherichia coli. FEMS Immunol Med Microbiol. 2010;59:447-55 pubmed publisher
    ..The use of lytic bacteriophages against established biofilms of Proteus mirabilis and Escherichia coli is described, whereby biofilm populations have been reduced successfully by three to ..
  80. Kurihara S, Sakai Y, Suzuki H, Muth A, Phanstiel O, Rather P. Putrescine importer PlaP contributes to swarming motility and urothelial cell invasion in Proteus mirabilis. J Biol Chem. 2013;288:15668-76 pubmed publisher
    ..that the speA gene, encoding arginine decarboxylase, is required for swarming in the urinary tract pathogen Proteus mirabilis. In addition, this previous study suggested that putrescine may act as a cell-to-cell signaling molecule (..
  81. Savory N, Lednor D, Tsukakoshi K, Abe K, Yoshida W, Ferri S, et al. In silico maturation of binding-specificity of DNA aptamers against Proteus mirabilis. Biotechnol Bioeng. 2013;110:2573-80 pubmed publisher
    b>Proteus mirabilis is a prominent cause of catheter-associated urinary tract infections (CAUTIs) among patients undergoing long-term bladder catheterization. There are currently no effective means of preventing P...
  82. Broomfield R, Morgan S, Khan A, Stickler D. Crystalline bacterial biofilm formation on urinary catheters by urease-producing urinary tract pathogens: a simple method of control. J Med Microbiol. 2009;58:1367-75 pubmed publisher
    ..b>Proteus mirabilis, Proteus vulgaris and Providencia rettgeri were able to raise the urinary pH above 8...
  83. Jacobsen S, Lane M, Harro J, Shirtliff M, Mobley H. The high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection. FEMS Immunol Med Microbiol. 2008;52:180-93 pubmed publisher
    b>Proteus mirabilis is a ubiquitous bacterium associated with complicated urinary tract infection (UTI)...
  84. Xue C, Budrene E, Othmer H. Radial and spiral stream formation in Proteus mirabilis colonies. PLoS Comput Biol. 2011;7:e1002332 pubmed publisher
    The enteric bacterium Proteus mirabilis, which is a pathogen that forms biofilms in vivo, can swarm over hard surfaces and form a variety of spatial patterns in colonies...