uropathogenic escherichia coli


Summary: Strains of Escherichia coli that preferentially grow and persist within the urinary tract. They exhibit certain virulence factors and infection pathways that cause URINARY TRACT INFECTIONS.

Top Publications

  1. Ho C, Fan C, Yu H, Wu C, Chen K, Liu S, et al. Testosterone suppresses uropathogenic Escherichia coli invasion and colonization within prostate cells and inhibits inflammatory responses through JAK/STAT-1 signaling pathway. PLoS ONE. 2017;12:e0180244 pubmed publisher
    Prostatitis is a common condition in adult men of all ages. Uropathogenic Escherichia coli (UPEC) are most frequent pathogen involved in bacterial prostatitis by refluxing the infected urine into prostatic ducts and resulting in an ..
  2. Kostakioti M, Hultgren S, Hadjifrangiskou M. Molecular blueprint of uropathogenic Escherichia coli virulence provides clues toward the development of anti-virulence therapeutics. Virulence. 2012;3:592-4 pubmed publisher
  3. Biswal B, Khairallah R, Bibi K, Mazza A, Gehr R, Masson L, et al. Impact of UV and peracetic acid disinfection on the prevalence of virulence and antimicrobial resistance genes in uropathogenic Escherichia coli in wastewater effluents. Appl Environ Microbiol. 2014;80:3656-66 pubmed
    ..peracetic acid (PAA) disinfection on the prevalence of virulence and antimicrobial resistance genes in uropathogenic Escherichia coli (UPEC), the most abundant E. coli pathotype in municipal wastewaters...
  4. Skowron B, Baranowska A, Kaszuba Zwoinska J, Wiecek G, Malska Woźniak A, Heczko P, et al. Experimental model for acute kidney injury caused by uropathogenic Escherichia coli. Postepy Hig Med Dosw (Online). 2017;71:520-529 pubmed
    ..coli at 107 cfu/ml was demonstrated to induce renal AKI, whereas inoculation with 109 cfu/ml seemed to cause not only ascending pyelonephritis, but perhaps also bacteremia and urosepsis (prerenal component of AKI). ..
  5. Peron G, Sut S, Pellizzaro A, Brun P, Voinovich D, Castagliuolo I, et al. The antiadhesive activity of cranberry phytocomplex studied by metabolomics: Intestinal PAC-A metabolites but not intact PAC-A are identified as markers in active urines against uropathogenic Escherichia coli. Fitoterapia. 2017;122:67-75 pubmed publisher
  6. Lüthje P, Brauner A. Ag43 promotes persistence of uropathogenic Escherichia coli isolates in the urinary tract. J Clin Microbiol. 2010;48:2316-7 pubmed publisher
  7. Oliveira Pinto C, Diamantino C, Oliveira P, Reis M, Costa P, Paiva M, et al. Occurrence and characterization of class 1 integrons in Escherichia coli from healthy individuals and those with urinary infection. J Med Microbiol. 2017;66:577-583 pubmed publisher
    ..Co-resistance to clinically relevant fluoroquinolone and trimethoprim-sulfamethazole in all UPEC isolates is a cause for concern. These results expand the current knowledge of gene cassettes in both commensal and pathogenic E. coli. ..
  8. Berry M, Mathews R, Ferdinand J, Jing C, Loudon K, Wlodek E, et al. Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone. Cell. 2017;170:860-874.e19 pubmed publisher
    ..Our work reveals a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense. ..
  9. Pilipczuk J, Zalewska Piatek B, Bruzdziak P, Czub J, Wieczór M, Olszewski M, et al. Role of the disulfide bond in stabilizing and folding of the fimbrial protein DraE from uropathogenic Escherichia coli. J Biol Chem. 2017;292:16136-16149 pubmed publisher
    ..We also show that the disulfide bond in DraE is recognized by the DraB chaperone, indicating a mechanism that precludes the incorporation of less stable, non-oxidized DraE forms into the fimbriae. ..

More Information


  1. Spaulding C, Klein R, Ruer S, Kau A, Schreiber H, Cusumano Z, et al. Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist. Nature. 2017;546:528-532 pubmed publisher
    Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) affect 150 million people annually. Despite effective antibiotic therapy, 30-50% of patients experience recurrent UTIs...
  2. Sahlberg Bang C, Demirel I, Kruse R, Persson K. Global gene expression profiling and antibiotic susceptibility after repeated exposure to the carbon monoxide-releasing molecule-2 (CORM-2) in multidrug-resistant ESBL-producing uropathogenic Escherichia coli. PLoS ONE. 2017;12:e0178541 pubmed publisher
    ..infections is today a challenge due to the increasing prevalence of multidrug-resistant ESBL-producing uropathogenic Escherichia coli (UPEC)...
  3. Madelung M, Kronborg T, Doktor T, Struve C, Krogfelt K, Møller Jensen J. DFI-seq identification of environment-specific gene expression in uropathogenic Escherichia coli. BMC Microbiol. 2017;17:99 pubmed publisher
    During infection of the urinary tract, uropathogenic Escherichia coli (UPEC) are exposed to different environments, such as human urine and the intracellular environments of bladder epithelial cells...
  4. Da Silva L, de Mello Santos A, Silva R. Uropathogenic Escherichia coli pathogenicity islands and other ExPEC virulence genes may contribute to the genome variability of enteroinvasive E. coli. BMC Microbiol. 2017;17:68 pubmed publisher
    ..The presence of phylogroups B2 and E strains allied to the presence of UPEC virulence-associated genes may underscore the ongoing evolution of EIEC towards a hypervirulent pathotype. ..
  5. MITTAL S, Sharma M, Chaudhary U. Biofilm and multidrug resistance in uropathogenic Escherichia coli. Pathog Glob Health. 2015;109:26-9 pubmed publisher
    ..These isolates were found to be resistant to antibiotics common in use and were 100% MDR. Biofilm production makes the organism to be more resistant to antibiotics and virulent as compared to non-biofilm producers. ..
  6. Heitmueller M, Billion A, Dobrindt U, Vilcinskas A, Mukherjee K. Epigenetic Mechanisms Regulate Innate Immunity against Uropathogenic and Commensal-Like Escherichia coli in the Surrogate Insect Model Galleria mellonella. Infect Immun. 2017;85: pubmed publisher
    ..coli in G. mellonella larvae, which may be relevant to understanding the different behaviors of these bacterial strains in the human urinary tract. ..
  7. Mydock McGrane L, Hannan T, Janetka J. Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn's disease. Expert Opin Drug Discov. 2017;12:711-731 pubmed publisher
  8. Ohlemacher S, Giblin D, d Avignon D, Stapleton A, Trautner B, Henderson J. Enterobacteria secrete an inhibitor of Pseudomonas virulence during clinical bacteriuria. J Clin Invest. 2017;127:4018-4030 pubmed publisher
    ..Future UTI-preventive probiotic strains may benefit by retaining the escherichelin biosynthetic capacity of the Yersinia HPI while eliminating the Ybt biosynthetic capacity. ..
  9. Sarshar S, Brandt S, Asadi Karam M, Habibi M, Bouzari S, Lechtenberg M, et al. Aqueous extract from Orthosiphon stamineus leaves prevents bladder and kidney infection in mice. Phytomedicine. 2017;28:1-9 pubmed publisher
    ..Evaluation of an aqueous extract against infection with uropathogenic Escherichia coli in vivo; investigation of underlying microbiological mechanisms...
  10. Ernstsen C, Login F, Jensen H, Nørregaard R, Møller Jensen J, Nejsum L. Detection and quantification of intracellular bacterial colonies by automated, high-throughput microscopy. J Microbiol Methods. 2017;139:37-44 pubmed publisher
    ..As a model we quantified intracellular bacterial colonies formed by uropathogenic Escherichia coli (UPEC) during infection of human kidney cells (HKC-8)...
  11. Howell A, Souza D, Roller M, Fromentin E. Comparison of the Anti-Adhesion Activity of Three Different Cranberry Extracts on Uropathogenic P-fimbriated Escherichia coli: a Randomized, Double-blind, Placebo Controlled, Ex Vivo, Acute Study. Nat Prod Commun. 2015;10:1215-8 pubmed
    ..All three cranberry extracts significantly increased anti-adhesion activity in urine. from 6 to 12 hours after intake of a single dose standardized to deliver 36 mg of PACs (as measured by the BL-DMAC method), versus placebo. ..
  12. Amabile Cuevas C, Arredondo García J. Antimicrobial activity data in support of nitrofurantoin three times per day. J Antimicrob Chemother. 2011;66:1652-3 pubmed publisher
  13. Peron G, Pellizzaro A, Brun P, Schievano E, Mammi S, Sut S, et al. Antiadhesive Activity and Metabolomics Analysis of Rat Urine after Cranberry (Vaccinium macrocarpon Aiton) Administration. J Agric Food Chem. 2017;65:5657-5667 pubmed publisher
    ..at 2, 4, 8, and 24 h after cranberry intake and their antiadhesive properties were tested against uropathogenic Escherichia coli. The 8 h samples showed the highest activity...