extraintestinal pathogenic escherichia coli


Summary: Strains of Escherichia coli that possess virulence traits which allow them to invade, colonize, and induce disease in tissues outside of the GASTROINTESTINAL TRACT. They are a cause of URINARY TRACT INFECTIONS (UROPATHOGENIC ESCHERICHIA COLI); neonatal MENINGITIS; SEPSIS; PNEUMONIA; and SURGICAL WOUND INFECTION.

Top Publications

  1. Delannoy S, Beutin L, Mariani Kurkdjian P, Fleiss A, Bonacorsi S, Fach P. The Escherichia coli Serogroup O1 and O2 Lipopolysaccharides Are Encoded by Multiple O-antigen Gene Clusters. Front Cell Infect Microbiol. 2017;7:30 pubmed publisher
    ..coli (STEC) strains. ..
  2. Gaschignard J, Geslain G, Mallet C, Lorrot M, Blot N, Alison M, et al. Spondylodiscitis in a healthy 12-year-old girl with Extraintestinal pathogenic Escherichia coli (ExPEC) bacteraemia. BMC Infect Dis. 2017;17:380 pubmed publisher
    ..coli (ExPEC). Immunological work-up was normal. The identification of E. coli in a spondylodiscitis should lead to the search for immunosuppression of the host and virulence factors of the strain, particularly those of ExPEC. ..
  3. Shimizu T, Harada K, Tsuyuki Y, Kimura Y, Miyamoto T, Hatoya S, et al. In vitro efficacy of 16 antimicrobial drugs against a large collection of ?-lactamase-producing isolates of extraintestinal pathogenic Escherichia coli from dogs and cats. J Med Microbiol. 2017;66:1085-1091 pubmed publisher
    ..of candidate antimicrobials against extended-spectrum ?-lactamase (ESBL)-producing isolates of extraintestinal pathogenic Escherichia coli (ExPEC) from companion animals...
  4. Da Silva L, de Mello Santos A, Silva R. Uropathogenic Escherichia coli pathogenicity islands and other ExPEC virulence genes may contribute to the genome variability of enteroinvasive E. coli. BMC Microbiol. 2017;17:68 pubmed publisher
    ..The presence of phylogroups B2 and E strains allied to the presence of UPEC virulence-associated genes may underscore the ongoing evolution of EIEC towards a hypervirulent pathotype. ..
  5. Nicolas Chanoine M, Petitjean M, Mora A, Mayer N, Lavigne J, Boulet O, et al. The ST131 Escherichia coli H22 subclone from human intestinal microbiota: Comparison of genomic and phenotypic traits with those of the globally successful H30 subclone. BMC Microbiol. 2017;17:71 pubmed publisher
    ..coli in our H30-R strains. ..
  6. Russell C, Richards A, Chang A, Mulvey M. The Rhomboid Protease GlpG Promotes the Persistence of Extraintestinal Pathogenic Escherichia coli within the Gut. Infect Immun. 2017;85: pubmed publisher
    ..This work reveals a novel biological role for a rhomboid protease and highlights new avenues for defining mechanisms by which ExPEC strains colonize the mammalian gastrointestinal tract. ..
  7. Zhu Y, Dong W, Ma J, Yuan L, Hejair H, Pan Z, et al. Characterization and virulence clustering analysis of extraintestinal pathogenic Escherichia coli isolated from swine in China. BMC Vet Res. 2017;13:94 pubmed publisher
    Swine extraintestinal pathogenic Escherichia coli (ExPEC) is an important pathogen that leads to economic and welfare costs in the swine industry worldwide, and is occurring with increasing frequency in China...
  8. Kong L, Guo X, Wang Z, Gao Y, Jia B, Liu S, et al. Whole genome sequencing of an ExPEC that caused fatal pneumonia at a pig farm in Changchun, China. BMC Vet Res. 2017;13:169 pubmed publisher
    In recent years, highly frequent swine respiratory diseases have been caused by extraintestinal pathogenic Escherichia coli (ExPEC) in China...
  9. Poole N, Green S, Rajan A, Vela L, Zeng X, Estes M, et al. Role for FimH in Extraintestinal Pathogenic Escherichia coli Invasion and Translocation through the Intestinal Epithelium. Infect Immun. 2017;85: pubmed publisher
    ..Our study also highlights the use of human intestinal enteroids in the study of enteric diseases. ..

More Information


  1. Magistro G, Magistro C, Stief C, Schubert S. The high-pathogenicity island (HPI) promotes flagellum-mediated motility in extraintestinal pathogenic Escherichia coli. PLoS ONE. 2017;12:e0183950 pubmed publisher
    The key of success of extraintestinal pathogenic Escherichia coli (ExPEC) to colonize niches outside the intestinal tract and to establish infection is the coordinated action of numerous virulence and fitness factors...