enteropathogenic escherichia coli


Summary: Strains of ESCHERICHIA COLI characterized by attaching-and-effacing histopathology. These strains of bacteria intimately adhere to the epithelial cell membrane and show effacement of microvilli. In developed countries they are associated with INFANTILE DIARRHEA and infantile GASTROENTERITIS and, in contrast to ETEC strains, do not produce ENDOTOXINS.

Top Publications

  1. Scott N, Giogha C, Pollock G, Kennedy C, Webb A, Williamson N, et al. The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD). J Biol Chem. 2017;292:17337-17350 pubmed publisher
    ..We conclude that, at normal levels of expression during bacterial infection, NleB1/NleBCR antagonizes death receptor-induced apoptosis of infected cells by modifying FADD in an irreversible manner. ..
  2. Katsowich N, Elbaz N, Pal R, Mills E, Kobi S, Kahan T, et al. Host cell attachment elicits posttranscriptional regulation in infecting enteropathogenic bacteria. Science. 2017;355:735-739 pubmed publisher
    ..The CesT-CsrA interaction provokes reprogramming of expression of virulence and metabolic genes. This regulation is likely required for the pathogen's adaptation to life on the epithelium surface. ..
  3. Hartland E, Leong J. Enteropathogenic and enterohemorrhagic E. coli: ecology, pathogenesis, and evolution. Front Cell Infect Microbiol. 2013;3:15 pubmed publisher
  4. Spano L, da Cunha K, Monfardini M, de Cássia Bergamaschi Fonseca R, Scaletsky I. High prevalence of diarrheagenic Escherichia coli carrying toxin-encoding genes isolated from children and adults in southeastern Brazil. BMC Infect Dis. 2017;17:773 pubmed publisher
    ..High levels of resistance to antimicrobial drugs were found among DAEC and aEPEC isolates. The results show a high proportion of EAEC and DAEC carrying toxin-encoding genes among adults with diarrhea. ..
  5. Santiago A, Yan M, Hazen T, Sauder B, Meza Segura M, Rasko D, et al. The AraC Negative Regulator family modulates the activity of histone-like proteins in pathogenic bacteria. PLoS Pathog. 2017;13:e1006545 pubmed publisher
    ..In conclusion, this work further extends our knowledge of genes under the control of Aar and its biological relevance in vivo. ..
  6. Guest R, Wang J, Wong J, Raivio T. A Bacterial Stress Response Regulates Respiratory Protein Complexes To Control Envelope Stress Adaptation. J Bacteriol. 2017;199: pubmed publisher
  7. El Qaidi S, Chen K, Halim A, Siukstaite L, Rueter C, Hurtado Guerrero R, et al. NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity. J Biol Chem. 2017;292:11423-11430 pubmed publisher
    ..These results provide evidence that members of this highly conserved family of bacterial virulence effectors target different host protein substrates and exhibit distinct cellular modes of action to suppress host responses. ..
  8. Singhal M, Manzella C, Soni V, Alrefai W, Saksena S, Hecht G, et al. Role of SHP2 protein tyrosine phosphatase in SERT inhibition by enteropathogenic E. coli (EPEC). Am J Physiol Gastrointest Liver Physiol. 2017;312:G443-G449 pubmed publisher
    ..These studies highlight host-pathogen interactions, which may be of therapeutic relevance in the management of diarrhea associated with enteric infections. ..
  9. Pourakbari B, Heydari H, Mahmoudi S, Sabouni F, Teymuri M, Ferdosian F, et al. Diarrhoeagenic E. coli pathotypes in children with and without diarrhoea in an Iranian referral paediatrics centre. East Mediterr Health J. 2013;19:617-21 pubmed
    ..La proportion élevée de souches E. coli diarrhéogènes et la diversité des types d'E. coli soulignent la nécessité d'une surveillance accrue des agents de gastro-entérites chez les enfants de ce pays. ..

More Information


  1. Slinger R, Lau K, Slinger M, Moldovan I, Chan F. Higher atypical enteropathogenic Escherichia coli (a-EPEC) bacterial loads in children with diarrhea are associated with PCR detection of the EHEC factor for adherence 1/lymphocyte inhibitory factor A (efa1/lifa) gene. Ann Clin Microbiol Antimicrob. 2017;16:16 pubmed publisher
    Typical enteropathogenic Escherichia coli (t-EPEC) are known to cause diarrhea in children but it is uncertain whether atypical EPEC (a-EPEC) do, since a-EPEC lack the bundle-forming pilus (bfp) gene that encodes a key adherence factor ..
  2. Zhang Z, Lai S, Yu J, Yang W, Wang X, Jing H, et al. [Epidemiological characteristics of diarrheagenic Escherichia coli among diarrhea outpatients in China, 2012-2015]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38:419-423 pubmed publisher
    ..3%????????????etec??653??21.9%???????25~34???????????????dec????????????10.1%?11.1%?9.4%?dec???????????????????????? ??? dec?????????????????????eaec?epec?etec?????????????????????????????. ..
  3. Manko A, Motta J, Cotton J, Feener T, Oyeyemi A, Vallance B, et al. Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease. PLoS ONE. 2017;12:e0178647 pubmed publisher
    ..duodenalis trophozoites and enteropathogenic Escherichia coli (EPEC) enhanced the production of the AMPs human ?-defensin 2 (HBD-2) and TFF3; this effect was ..
  4. Pedersen G, Jensen H, Schelde A, Toft C, Pedersen H, Ulrichsen M, et al. The basolateral vesicle sorting machinery and basolateral proteins are recruited to the site of enteropathogenic E. coli microcolony growth at the apical membrane. PLoS ONE. 2017;12:e0179122 pubmed publisher
    Foodborne Enteropathogenic Escherichia coli (EPEC) infections of the small intestine cause diarrhea especially in children and are a major cause of childhood death in developing countries...
  5. Buschor S, Cuenca M, Uster S, Schären O, Balmer M, Terrazos M, et al. Innate immunity restricts Citrobacter rodentium A/E pathogenesis initiation to an early window of opportunity. PLoS Pathog. 2017;13:e1006476 pubmed publisher
    ..Our data demonstrate that the establishment phase of C. rodentium pathogenesis in vivo is restricted to a very short window of opportunity that determines both disease geography and severity. ..
  6. Mills E, Baruch K, Aviv G, Nitzan M, Rosenshine I. Dynamics of the type III secretion system activity of enteropathogenic Escherichia coli. MBio. 2013;4: pubmed publisher
    ..alongside a previously described real-time population-based translocation assay, focusing mainly on enteropathogenic Escherichia coli (EPEC) and partly comparing it to Salmonella...
  7. Hughes K. The locus of enterocyte effacement type III secretion specificity switch: the devil's in the data for a common mechanism. J Bacteriol. 2012;194:6019-22 pubmed publisher
  8. Xu Y, Bai X, Jin Y, Hu B, Wang H, Sun H, et al. High Prevalence of Virulence Genes in Specific Genotypes of Atypical Enteropathogenic Escherichia coli. Front Cell Infect Microbiol. 2017;7:109 pubmed publisher
    ..The high prevalence of diarrhea-associated genes in animal or raw meat strains suggests a zoonotic transmission pathway for potentially human pathogenic aEPEC. ..
  9. Mellies J, Platenkamp A, Osborn J, Ben Avi L. PerC Manipulates Metabolism and Surface Antigens in Enteropathogenic Escherichia coli. Front Cell Infect Microbiol. 2017;7:32 pubmed publisher
    ..In sum, this protein controls niche adaptation, and could help to explain the function of the PerC homologs (Pch), many of which are encoded within prophages in related, Gram-negative pathogens. ..