citrobacter rodentium

Summary

Summary: A species of gram-negative bacteria in the genus CITROBACTER, family ENTEROBACTERIACEAE. As an important pathogen of laboratory mice, it serves as a model for investigating epithelial hyperproliferation and tumor promotion. It was previously considered a strain of CITROBACTER FREUNDII.

Top Publications

  1. Collins J, Akin A, Kosta A, Zhang N, Tangney M, Francis K, et al. Pre-treatment with Bifidobacterium breve UCC2003 modulates Citrobacter rodentium-induced colonic inflammation and organ specificity. Microbiology. 2012;158:2826-34 pubmed publisher
    b>Citrobacter rodentium, which colonizes the gut mucosa via formation of attaching and effacing (A/E) lesions, causes transmissible colonic hyperplasia...
  2. Bry L, Brigl M, Brenner M. CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium. Infect Immun. 2006;74:673-81 pubmed
    b>Citrobacter rodentium causes an attaching and effacing infection of the mouse colon. Surprisingly, protective adaptive immunity against this mucosal pathogen requires a systemic T-cell-dependent antibody response...
  3. Gibson D, Ma C, Bergstrom K, Huang J, Man C, Vallance B. MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis. Cell Microbiol. 2008;10:618-31 pubmed
    ..The current study investigated the role of MyD88 following infection by the murine bacterial pathogen, Citrobacter rodentium. MyD88-deficient mice suffered a lethal colitis coincident with colonic mucosal ulcerations and bleeding...
  4. Gueguen E, Cascales E. Promoter swapping unveils the role of the Citrobacter rodentium CTS1 type VI secretion system in interbacterial competition. Appl Environ Microbiol. 2013;79:32-8 pubmed publisher
    ..b>Citrobacter rodentium, a rodent pathogen, harbors two T6SS gene clusters, cts1 and cts2...
  5. Kiss E, Vonarbourg C, Kopfmann S, Hobeika E, Finke D, Esser C, et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science. 2011;334:1561-5 pubmed publisher
    ..AhR-deficient mice were highly susceptible to infection with Citrobacter rodentium, a mouse model for attaching and effacing infections...
  6. Deng W, Puente J, Gruenheid S, Li Y, Vallance B, Vazquez A, et al. Dissecting virulence: systematic and functional analyses of a pathogenicity island. Proc Natl Acad Sci U S A. 2004;101:3597-602 pubmed
    ..Human enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli, and the mouse pathogen Citrobacter rodentium (CR) possess the locus of enterocyte effacement (LEE) PAI...
  7. Chandrakesan P, Ahmed I, Anwar T, Wang Y, Sarkar S, Singh P, et al. Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38. J Biol Chem. 2010;285:33485-98 pubmed publisher
    Utilizing the Citrobacter rodentium-induced transmissible murine colonic hyperplasia (TMCH) model, we measured hyperplasia and NF-?B activation during progression (days 6 and 12 post-infection) and regression (days 20-34 post-infection) ..
  8. Borenshtein D, Nambiar P, Groff E, Fox J, Schauer D. Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Infect Immun. 2007;75:3271-81 pubmed
    b>Citrobacter rodentium is the causative agent of transmissible murine colonic hyperplasia...
  9. Guttman J, Li Y, Wickham M, Deng W, Vogl A, Finlay B. Attaching and effacing pathogen-induced tight junction disruption in vivo. Cell Microbiol. 2006;8:634-45 pubmed
    ..These results suggest that the diarrhoea induced by A/E pathogens occurs as part of functional tight junction disruption. ..

More Information

Publications96

  1. Roe A, Tysall L, Dransfield T, Wang D, Fraser Pitt D, Mahajan A, et al. Analysis of the expression, regulation and export of NleA-E in Escherichia coli O157 : H7. Microbiology. 2007;153:1350-60 pubmed
    ..Additionally, a family of non-LEE-encoded (Nle) effector proteins has been shown to be secreted from Citrobacter rodentium, homologues of which are located on the E. coli O157 chromosome...
  2. Wiles S, Dougan G, Frankel G. Emergence of a 'hyperinfectious' bacterial state after passage of Citrobacter rodentium through the host gastrointestinal tract. Cell Microbiol. 2005;7:1163-72 pubmed
    b>Citrobacter rodentium belongs to a family of human and animal enteric pathogens that includes the clinically significant enterohaemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC)...
  3. Wu X, Vallance B, Boyer L, Bergstrom K, Walker J, Madsen K, et al. Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors. Am J Physiol Gastrointest Liver Physiol. 2008;294:G295-306 pubmed
    ..The aim of this study was to examine the ameliorating effects of S. boulardii on Citrobacter rodentium colitis in vivo and identify potential mechanisms of action. C57BL/6 mice received 2.5 x 10(8) C...
  4. Maaser C, Housley M, Iimura M, Smith J, Vallance B, Finlay B, et al. Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun. 2004;72:3315-24 pubmed
    b>Citrobacter rodentium, a murine model pathogen for human enteropathogenic Escherichia coli, predominantly colonizes the lumen and mucosal surface of the colon and cecum and causes crypt hyperplasia and mucosal inflammation...
  5. Sonnenberg G, Monticelli L, Elloso M, Fouser L, Artis D. CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity. 2011;34:122-34 pubmed publisher
    ..We demonstrate that after infection with Citrobacter rodentium, CD4(+) LTi cells were a dominant source of interleukin-22 (IL-22) early during infection...
  6. Ma C, Wickham M, Guttman J, Deng W, Walker J, Madsen K, et al. Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map). Cell Microbiol. 2006;8:1669-86 pubmed
    ..Using Citrobacter rodentium, a mouse-adapted A/E bacterium, we found that Map colocalized with host cell mitochondria, and that in ..
  7. Johnson Henry K, Nadjafi M, Avitzur Y, Mitchell D, Ngan B, Galindo Mata E, et al. Amelioration of the effects of Citrobacter rodentium infection in mice by pretreatment with probiotics. J Infect Dis. 2005;191:2106-17 pubmed
    b>Citrobacter rodentium is a naturally occurring murine pathogen that causes colonic epithelial-cell hyperplasia, disrupts the colonic mucosa, and elicits a predominantly T helper 1 cellular immune response; it thereby serves as a model ..
  8. Cheng C, Tennant S, Azzopardi K, Bennett Wood V, Hartland E, Robins Browne R, et al. Contribution of the pst-phoU operon to cell adherence by atypical enteropathogenic Escherichia coli and virulence of Citrobacter rodentium. Infect Immun. 2009;77:1936-44 pubmed publisher
    ..contributes to bacterial colonization in vivo, a pstCA mutation was made in the EPEC-like murine pathogen, Citrobacter rodentium. C57BL/6 mice infected perorally with the pstCA mutant of C...
  9. Chen C, Louie S, Shi H, Walker W. Preinoculation with the probiotic Lactobacillus acidophilus early in life effectively inhibits murine Citrobacter rodentium colitis. Pediatr Res. 2005;58:1185-91 pubmed
    ..The mouse pathogen Citrobacter rodentium causes a similar A/E lesion in the murine intestine. Like EPEC, C...
  10. Lupp C, Robertson M, Wickham M, Sekirov I, Champion O, Gaynor E, et al. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe. 2007;2:204 pubmed
    ..Using mouse models of Citrobacter rodentium, which closely mimics human diarrheal pathogens inducing host intestinal inflammation, and Campylobacter ..
  11. D Arienzo R, Maurano F, Mazzarella G, Luongo D, Stefanile R, Ricca E, et al. Bacillus subtilis spores reduce susceptibility to Citrobacter rodentium-mediated enteropathy in a mouse model. Res Microbiol. 2006;157:891-7 pubmed
    ..To address this issue, we developed a mouse model of infection using the mouse enteropathogen Citrobacter rodentium, a member of a family of human and animal pathogens which includes the clinically significant ..
  12. McBee M, Zheng P, Rogers A, Fox J, Schauer D. Modulation of acute diarrheal illness by persistent bacterial infection. Infect Immun. 2008;76:4851-8 pubmed publisher
    Acute diarrheal illness is a global health problem that may be exacerbated by concurrent infection. Using Citrobacter rodentium, a murine model of attaching and effacing diarrheagenic Escherichia coli, we demonstrate that persistent ..
  13. Coulthurst S, Clare S, Evans T, Foulds I, Roberts K, Welch M, et al. Quorum sensing has an unexpected role in virulence in the model pathogen Citrobacter rodentium. EMBO Rep. 2007;8:698-703 pubmed
    The bacterial mouse pathogen Citrobacter rodentium causes attaching and effacing (AE) lesions in the same manner as pathogenic Escherichia coli, and is an important model for this mode of pathogenesis...
  14. Hoffmann C, Hill D, Minkah N, Kirn T, Troy A, Artis D, et al. Community-wide response of the gut microbiota to enteropathogenic Citrobacter rodentium infection revealed by deep sequencing. Infect Immun. 2009;77:4668-78 pubmed publisher
    We investigated the spatial and temporal response of the murine gut microbiome to infection with Citrobacter rodentium, an attaching-and-effacing bacterium that provokes innate and adaptive immune responses, resulting in transient ..
  15. Borenshtein D, McBee M, Schauer D. Utility of the Citrobacter rodentium infection model in laboratory mice. Curr Opin Gastroenterol. 2008;24:32-7 pubmed
    ..these diarrhea-causing pathogens, a growing number of studies have found the murine bacterial pathogen Citrobacter rodentium to provide a robust, relevant in-vivo model system...
  16. Shiomi H, Masuda A, Nishiumi S, Nishida M, Takagawa T, Shiomi Y, et al. Gamma interferon produced by antigen-specific CD4+ T cells regulates the mucosal immune responses to Citrobacter rodentium infection. Infect Immun. 2010;78:2653-66 pubmed publisher
    b>Citrobacter rodentium, a murine model pathogen for enteropathogenic Escherichia coli, colonizes the surface of intestinal epithelial cells and causes mucosal inflammation...
  17. Bry L, Brenner M. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol. 2004;172:433-41 pubmed
    b>Citrobacter rodentium uses virulence factors similar to the enteropathogenic Escherichia coli to produce attaching and effacing lesions in the distal colon of mice...
  18. Manta C, Heupel E, Radulovic K, Rossini V, Garbi N, Riedel C, et al. CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium. Mucosal Immunol. 2013;6:177-88 pubmed publisher
    ..study the role of CX(3)CR1(+) DCs and macrophages in host defence, we infected CX(3)CR1-GFP animals with Citrobacter rodentium. When transgenic CX(3)CR1-GFP animals are infected with the natural mouse pathogen C...
  19. Gareau M, Wine E, Reardon C, Sherman P. Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice. J Infect Dis. 2010;201:81-91 pubmed publisher
    ..Therefore, the aims of this study were to characterize Citrobacter rodentium infection in neonatal mice and determine the role played by specific probiotics in ameliorating disease ..
  20. Khan M, Bouzari S, Ma C, Rosenberger C, Bergstrom K, Gibson D, et al. Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium. Infect Immun. 2008;76:1410-22 pubmed publisher
    Enteropathogenic Escherichia coli (EPEC) and the murine pathogen Citrobacter rodentium belong to the attaching and effacing (A/E) family of bacterial pathogens...
  21. Symonds E, Riedel C, O Mahony D, Lapthorne S, O Mahony L, Shanahan F. Involvement of T helper type 17 and regulatory T cell activity in Citrobacter rodentium invasion and inflammatory damage. Clin Exp Immunol. 2009;157:148-54 pubmed publisher
    b>Citrobacter rodentium is a murine pathogen that transiently colonizes the lumen of the large intestine. C...
  22. Gareau M, Wine E, Rodrigues D, Cho J, Whary M, Philpott D, et al. Bacterial infection causes stress-induced memory dysfunction in mice. Gut. 2011;60:307-17 pubmed publisher
    ..Behaviour was assessed following infection with the non-invasive enteric pathogen, Citrobacter rodentium in both C57BL/6 mice and germ-free Swiss-Webster mice, in the presence or absence of acute water avoidance ..
  23. Wlodarska M, Willing B, Keeney K, Menendez A, Bergstrom K, Gill N, et al. Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis. Infect Immun. 2011;79:1536-45 pubmed publisher
    ..b>Citrobacter rodentium was used as a model enteric pathogen to investigate the effect of microbial perturbation on intestinal ..
  24. Tumanov A, Koroleva E, Guo X, Wang Y, Kruglov A, Nedospasov S, et al. Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge. Cell Host Microbe. 2011;10:44-53 pubmed publisher
    ..Using mice infected with the natural mouse enteric pathogen Citrobacter rodentium, we demonstrate that lymphotoxin (LT) is essential for IL-22 production by intestinal ILCs...
  25. Wei O, Hilliard A, Kalman D, Sherman M. Mast cells limit systemic bacterial dissemination but not colitis in response to Citrobacter rodentium. Infect Immun. 2005;73:1978-85 pubmed
    ..b>Citrobacter rodentium causes a similar colitis in mice and serves as a model for enteropathogenic E. coli infection in humans. C...
  26. Kaniuk N, Lam G, Ma C, Galindo Mata E, Jones N, Vallance B, et al. Citrobacter rodentium infection induces MyD88-dependent formation of ubiquitinated protein aggregates in the intestinal epithelium. J Innate Immun. 2011;3:83-98 pubmed publisher
    b>Citrobacter rodentium utilizes a type 3 secretion system (T3SS) to inject effector proteins into host intestinal epithelial cells, causing structural and functional changes in these cells during infection...
  27. McConnell B, Klapproth J, Sasaki M, Nandan M, Yang V. Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection. Gastroenterology. 2008;134:1007-16 pubmed publisher
    ..mediating proliferative responses to intestinal stressors in vivo, we examined its function in a mouse model of transmissible murine colonic hyperplasia triggered by colonization of the mouse colon by the bacteria Citrobacter rodentium.
  28. Borenshtein D, Fry R, Groff E, Nambiar P, Carey V, Fox J, et al. Diarrhea as a cause of mortality in a mouse model of infectious colitis. Genome Biol. 2008;9:R122 pubmed publisher
    ..profiling of the mouse colon was carried out in two cognate lines of mice that differ in their response to Citrobacter rodentium infection; susceptible inbred FVB/N and resistant outbred Swiss Webster mice...
  29. Lebeis S, Powell K, Merlin D, Sherman M, Kalman D. Interleukin-1 receptor signaling protects mice from lethal intestinal damage caused by the attaching and effacing pathogen Citrobacter rodentium. Infect Immun. 2009;77:604-14 pubmed publisher
    Enteropathogenic Escherichia coli, enterohemorrhagic E. coli, and Citrobacter rodentium are classified as attaching and effacing pathogens based on their ability to adhere to the intestinal epithelium via actin-filled membranous ..
  30. Zheng Y, Valdez P, Danilenko D, Hu Y, Sa S, Gong Q, et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med. 2008;14:282-9 pubmed publisher
    ..Using a mouse A/E pathogen, Citrobacter rodentium, we show that interleukin-22 (IL-22) has a crucial role in the early phase of host defense against C...
  31. Petty N, Toribio A, Goulding D, Foulds I, Thomson N, Dougan G, et al. A generalized transducing phage for the murine pathogen Citrobacter rodentium. Microbiology. 2007;153:2984-8 pubmed
    A virulent phage (phiCR1) capable of generalized transduction in Citrobacter rodentium was isolated from the environment and characterized. C. rodentium is a natural pathogen of mice, causing transmissible murine colonic hyperplasia...
  32. Jones S, Knight K. Bacillus subtilis-mediated protection from Citrobacter rodentium-associated enteric disease requires espH and functional flagella. Infect Immun. 2012;80:710-9 pubmed publisher
    ..The attaching and effacing mouse pathogen Citrobacter rodentium associates intimately with the intestinal epithelium, and infections result in acute colitis. C...
  33. Baker J, Brown K, Rajendiran E, Yip A, Decoffe D, Dai C, et al. Medicinal lavender modulates the enteric microbiota to protect against Citrobacter rodentium-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2012;303:G825-36 pubmed publisher
    ..Lavandula×intermedia cultivar Okanagan lavender (OLEO), in a mouse model of acute colitis caused by Citrobacter rodentium. In colitic mice, oral gavage with OLEO resulted in less severe disease, including decreased morbidity and ..
  34. Chen C, Louie S, McCormick B, Walker W, Shi H. Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infect Immun. 2005;73:5468-81 pubmed
    ..To analyze the modulatory effect of a Th2-inducing helminth on the outcome of enteric bacterium Citrobacter rodentium infection, BALB/c and STAT 6 knockout (KO) mice were infected with H. polygyrus, C. rodentium, or both...
  35. Brown J, Cheresh P, Goretsky T, Managlia E, Grimm G, Ryu H, et al. Epithelial phosphatidylinositol-3-kinase signaling is required for ?-catenin activation and host defense against Citrobacter rodentium infection. Infect Immun. 2011;79:1863-72 pubmed publisher
    b>Citrobacter rodentium infection of mice induces cell-mediated immune responses associated with crypt hyperplasia and epithelial ?-catenin signaling...
  36. Wiles S, Clare S, Harker J, Huett A, Young D, Dougan G, et al. Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium. Cell Microbiol. 2004;6:963-72 pubmed
    b>Citrobacter rodentium belongs to a family of human and animal enteric pathogens that includes the clinically significant enterohaemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC)...
  37. Spahn T, Maaser C, Eckmann L, Heidemann J, Lugering A, Newberry R, et al. The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitis. Gastroenterology. 2004;127:1463-73 pubmed
    ..Infection of mice with Citrobacter rodentium serves as an animal model for human infectious colitis induced by enteropathogenic Escherichia coli ...
  38. Liu Z, Zaki M, Vogel P, Gurung P, Finlay B, Deng W, et al. Role of inflammasomes in host defense against Citrobacter rodentium infection. J Biol Chem. 2012;287:16955-64 pubmed publisher
    b>Citrobacter rodentium is an enteric bacterial pathogen of the mouse intestinal tract that triggers inflammatory responses resembling those of humans infected with enteropathogenic and enterohemorrhagic Escherichia coli...
  39. Assi K, Bergstrom K, Vallance B, Owen D, Salh B. Requirement of epithelial integrin-linked kinase for facilitation of Citrobacter rodentium-induced colitis. BMC Gastroenterol. 2013;13:137 pubmed publisher
    ..Recently ILK been shown to have an important role in bacterial epithelial cell attachment, through ILK-bacterial OspE binding. Here we report on the role of epithelial derived ILK in response to Citrobacter rodentium infection.
  40. Flynn A, Buret A. Tight junctional disruption and apoptosis in an in vitro model of Citrobacter rodentium infection. Microb Pathog. 2008;45:98-104 pubmed publisher
    The murine model of Citrobacter rodentium infection has been used to complement in vitro studies of enteropathogenic Escherichia coli (EPEC) infections of human intestinal epithelial cells (IECs)...
  41. Crepin V, Girard F, Schüller S, Phillips A, Mousnier A, Frankel G. Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo. Mol Microbiol. 2010;75:308-23 pubmed publisher
    ..coli (EHEC) and Citrobacter rodentium (CR) infections, are dependent on the effector Tir...
  42. Dong T, Coombes B, Schellhorn H. Role of RpoS in the virulence of Citrobacter rodentium. Infect Immun. 2009;77:501-7 pubmed publisher
    b>Citrobacter rodentium is a mouse enteropathogen that is closely related to Escherichia coli and causes severe colonic hyperplasia and bloody diarrhea. C...
  43. Iimura M, Gallo R, Hase K, Miyamoto Y, Eckmann L, Kagnoff M. Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J Immunol. 2005;174:4901-7 pubmed
    ..Synthetic mCRAMP had antimicrobial activity against the murine enteric pathogen Citrobacter rodentium, which like the related clinically important human pathogens enteropathogenic Escherichia coli and ..
  44. Le Sage V, Zhu L, Lepage C, Portt A, Viau C, Daigle F, et al. An outer membrane protease of the omptin family prevents activation of the Citrobacter rodentium PhoPQ two-component system by antimicrobial peptides. Mol Microbiol. 2009;74:98-111 pubmed publisher
    ..A homologue of the phoPQ operon was found in the genome of the murine enteric extracellular pathogen, Citrobacter rodentium. Here we report that C...
  45. Conlin V, Wu X, Nguyen C, Dai C, Vallance B, Buchan A, et al. Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2009;297:G735-50 pubmed publisher
    ..The aim of this study was to examine whether VIP treatment modulated Citrobacter rodentium-induced disruption of intestinal barrier integrity and to identify potential mechanisms of action...
  46. Chen C, Chiu C, Lin T, Shi H, Walker W. Effect of probiotics Lactobacillus acidophilus on Citrobacter rodentium colitis: the role of dendritic cells. Pediatr Res. 2009;65:169-75 pubmed publisher
    ..The above findings suggest that DCs play a key role in probiotics attenuating Citrobacter rodentium (Cr) colitis...
  47. Rankin L, Groom J, Chopin M, Herold M, Walker J, Mielke L, et al. The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway. Nat Immunol. 2013;14:389-95 pubmed publisher
    ..Our results pinpoint the regulation of Notch signaling by T-bet as a distinct molecular pathway that guides the development of NKp46+ ILCs...
  48. Hardwidge P, Deng W, Vallance B, Rodriguez Escudero I, Cid V, Molina M, et al. Modulation of host cytoskeleton function by the enteropathogenic Escherichia coli and Citrobacter rodentium effector protein EspG. Infect Immun. 2005;73:2586-94 pubmed
    ..and effacing (A/E) pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli and Citrobacter rodentium. EspG is delivered into infected host cells by a type III secretion system...
  49. Harrington L, Srikanth C, Antony R, Rhee S, Mellor A, Shi H, et al. Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis. Infect Immun. 2008;76:3045-53 pubmed publisher
    ..had elevated levels of IgA antibodies that cross-reacted with the gram-negative enteric bacterial pathogen Citrobacter rodentium. In keeping with the functional importance of this natural secretory IgA, the mutant animals were more ..
  50. Guttman J, Samji F, Li Y, Deng W, Lin A, Finlay B. Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens. Cell Microbiol. 2007;9:131-41 pubmed
    ..A natural murine infection model, employing the A/E pathogen Citrobacter rodentium, has been helpful in studying the diseases in vivo. C...
  51. Bergstrom K, Kissoon Singh V, Gibson D, Ma C, Montero M, Sham H, et al. Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa. PLoS Pathog. 2010;6:e1000902 pubmed publisher
    ..the role of Muc2 during A/E bacterial infections, we inoculated Muc2 deficient (Muc2(-/-)) mice with Citrobacter rodentium, a murine A/E pathogen related to diarrheagenic A/E E. coli...
  52. Ota N, Wong K, Valdez P, Zheng Y, Crellin N, Diehl L, et al. IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nat Immunol. 2011;12:941-8 pubmed publisher
    ..and regulated the organization and maintenance of mature CLPs and ILFs in the colon during infection with Citrobacter rodentium. Lymphotoxin (LT?(1)?(2)) regulated the production of IL-22 during infection with C...
  53. Schreiber H, Loschko J, Karssemeijer R, Escolano A, Meredith M, Mucida D, et al. Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium. J Exp Med. 2013;210:2025-39 pubmed publisher
    ..and macrophages in immunity to pathogens was tested by their selective depletion during infection with Citrobacter rodentium. Although neither cell type was required to initiate immunity, monocytes and macrophages contributed to ..
  54. Kim Y, Kamada N, Shaw M, Warner N, Chen G, Franchi L, et al. The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity. 2011;34:769-80 pubmed publisher
    ..We found that Nod2-/- mice exhibited impaired intestinal clearance of Citrobacter rodentium, an enteric bacterium that models human infection by pathogenic Escherichia coli...
  55. Linden S, Florin T, McGuckin M. Mucin dynamics in intestinal bacterial infection. PLoS ONE. 2008;3:e3952 pubmed publisher
    Bacterial gastroenteritis causes morbidity and mortality in humans worldwide. Murine Citrobacter rodentium infection is a model for gastroenteritis caused by the human pathogens enteropathogenic Escherichia coli and enterohaemorrhagic E...
  56. Wickham M, Lupp C, Mascarenhas M, Vazquez A, Coombes B, Brown N, et al. Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection. J Infect Dis. 2006;194:819-27 pubmed
    ..In vivo, Citrobacter rodentium mutants lacking outbreak- and HUS-associated genes were deficient for virulence in mice; in particular, ..
  57. Bishop A, Wiles S, Dougan G, Frankel G. Cell attachment properties and infectivity of host-adapted and environmentally adapted Citrobacter rodentium. Microbes Infect. 2007;9:1316-24 pubmed
    b>Citrobacter rodentium belongs to a family of extracellular enteric pathogens that include enterohaemorrhagic and enteropathogenic Escherichia coli, which colonises the gastrointestinal mucosa by the attaching and effacing (A/E) mechanism...
  58. Hart E, Yang J, Tauschek M, Kelly M, Wakefield M, Frankel G, et al. RegA, an AraC-like protein, is a global transcriptional regulator that controls virulence gene expression in Citrobacter rodentium. Infect Immun. 2008;76:5247-56 pubmed publisher
    b>Citrobacter rodentium is an attaching and effacing pathogen which causes transmissible colonic hyperplasia in mice. Infection with C...
  59. Gibson D, Ma C, Rosenberger C, Bergstrom K, Valdez Y, Huang J, et al. Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis. Cell Microbiol. 2008;10:388-403 pubmed
    ..These studies investigated the role of TLR2 in a model of murine colitis induced by the bacterial pathogen Citrobacter rodentium. C...
  60. Wang Y, Xiang G, Kourouma F, Umar S. Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation. Br J Pharmacol. 2006;148:814-24 pubmed
    ..2. During transmissible murine colonic hyperplasia (TMCH) induced by Citrobacter rodentium, nuclear translocation of NF-kappaB in isolated colonic crypts increased 3 day's post-infection and ..
  61. Rathinam V, Vanaja S, Waggoner L, Sokolovska A, Becker C, Stuart L, et al. TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell. 2012;150:606-19 pubmed publisher
    ..The identification of TRIF as a regulator of caspase-11 underscores the importance of TLRs as master regulators of inflammasomes during Gram-negative bacterial infection...
  62. Hall L, Murphy C, Hurley G, Quinlan A, Shanahan F, Nally K, et al. Natural killer cells protect against mucosal and systemic infection with the enteric pathogen Citrobacter rodentium. Infect Immun. 2013;81:460-9 pubmed publisher
    ..C57BL/6 mice were orally gavaged with Citrobacter rodentium, a murine pathogen related to human diarrheagenic Escherichia coli...
  63. Raczynski A, Muthupalani S, Schlieper K, Fox J, Tannenbaum S, Schauer D. Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. PLoS ONE. 2012;7:e33099 pubmed publisher
    ..C. rodentium infection in C57BL/6 mice provides a potentially useful model to study acute liver injury and inflammatory stress under conditions of gastrointestinal infection analogous to enteropathogenic E. coli infection in humans...
  64. Ren C, Beatson S, Parkhill J, Pallen M. The Flag-2 locus, an ancestral gene cluster, is potentially associated with a novel flagellar system from Escherichia coli. J Bacteriol. 2005;187:1430-40 pubmed
    ..The presence of the Flag-2 cluster at identical sites in E. coli and its close relative Citrobacter rodentium, combined with its absence from S...
  65. Bergstrom K, Guttman J, Rumi M, Ma C, Bouzari S, Khan M, et al. Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen. Infect Immun. 2008;76:796-811 pubmed
    ..coli and the related mouse pathogen Citrobacter rodentium colonize their hosts' intestines by infecting the apical surfaces of enterocytes, subverting their ..
  66. Yang J, Hart E, Tauschek M, Price G, Hartland E, Strugnell R, et al. Bicarbonate-mediated transcriptional activation of divergent operons by the virulence regulatory protein, RegA, from Citrobacter rodentium. Mol Microbiol. 2008;68:314-27 pubmed publisher
    ..regulation of two putative virulence determinants adcA and kfc by RegA, an AraC/XylS-like regulator, from Citrobacter rodentium, and identified bicarbonate as the environmental signal which induced transcription of adcA and kfc ..
  67. LeBlanc P, Yeretssian G, Rutherford N, Doiron K, Nadiri A, Zhu L, et al. Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity. Cell Host Microbe. 2008;3:146-57 pubmed publisher
    ..Nod activation and resulting antimicrobial peptide production constitute an early innate defense mechanism, and caspase-12 inhibits this mucosal antimicrobial response...
  68. García Angulo V, Deng W, Thomas N, Finlay B, Puente J. Regulation of expression and secretion of NleH, a new non-locus of enterocyte effacement-encoded effector in Citrobacter rodentium. J Bacteriol. 2008;190:2388-99 pubmed publisher
    Together with enterohemorrhagic Escherichia coli and enteropathogenic Escherichia coli, Citrobacter rodentium is a member of the attaching-and-effacing (A/E) family of bacterial pathogens...
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    ..Together, these results identify the Nod-iT(H)17 axis as a central element in controlling enteric pathogens, which may implicate Nod-driven iT(H)17 responses in the development of inflammatory bowel diseases...
  70. Satoh Takayama N, Vosshenrich C, Lesjean Pottier S, Sawa S, Lochner M, Rattis F, et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity. 2008;29:958-70 pubmed publisher
    ..Mice lacking IL-22-producing NKp46+ cells showed heightened susceptibility to the pathogen Citrobacter rodentium, consistent with a role for intestinal NKp46+ cells in immune protection...
  71. Lebeis S, Bommarius B, Parkos C, Sherman M, Kalman D. TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. J Immunol. 2007;179:566-77 pubmed
    Enteropathogenic Escherichia coli, enterohemorrhagic E. coli, and Citrobacter rodentium are classified as attaching and effacing pathogens based on their ability to adhere to intestinal epithelium via actin-filled membranous protrusions (..
  72. Bailey M, Dowd S, Parry N, Galley J, Schauer D, Lyte M. Stressor exposure disrupts commensal microbial populations in the intestines and leads to increased colonization by Citrobacter rodentium. Infect Immun. 2010;78:1509-19 pubmed publisher
    ..stressed mice, as well as nonstressed controls, were challenged orally with the enteric murine pathogen Citrobacter rodentium. Exposure to the restraint stressor led to a significant increase in C...
  73. Spehlmann M, Dann S, Hruz P, Hanson E, McCole D, Eckmann L. CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen. J Immunol. 2009;183:3332-43 pubmed publisher
    ..b>Citrobacter rodentium, a murine model pathogen that shares important functional features with EPEC, colonizes mice in colon and ..
  74. Qiu J, Heller J, Guo X, Chen Z, Fish K, Fu Y, et al. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity. 2012;36:92-104 pubmed publisher
    ..Ahr-deficient mice succumbed to Citrobacter rodentium infection, whereas ectopic expression of IL-22 protected animals from early mortality...
  75. Singh K, Chaturvedi R, Asim M, Barry D, Lewis N, Vitek M, et al. The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. J Biol Chem. 2008;283:16752-61 pubmed publisher
    ..b>Citrobacter rodentium is the rodent equivalent of enteropathogenic Escherichia coli, and it causes colitis in mice by colonizing ..
  76. Fattouh R, Guo C, Lam G, Gareau M, Ngan B, Glogauer M, et al. Rac2-deficiency leads to exacerbated and protracted colitis in response to Citrobacter rodentium infection. PLoS ONE. 2013;8:e61629 pubmed publisher
    ..impair host immune responses in the intestine and promote disease in the context of an infection-based (Citrobacter rodentium) model of colitis...
  77. Guttman J, Samji F, Li Y, Vogl A, Finlay B. Evidence that tight junctions are disrupted due to intimate bacterial contact and not inflammation during attaching and effacing pathogen infection in vivo. Infect Immun. 2006;74:6075-84 pubmed
    ..For in vivo experiments, the murine model of A/E infection with Citrobacter rodentium is the animal model of choice...
  78. Dahan S, Wiles S, La Ragione R, Best A, Woodward M, Stevens M, et al. EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics. Infect Immun. 2005;73:679-86 pubmed
    Enterohemorrhagic Escherichia coli, enteropathogenic E. coli, and Citrobacter rodentium are highly adapted enteropathogens that successfully colonize their host's gastrointestinal tract via the formation of attaching and effacing (A/E) ..
  79. Mundy R, Petrovska L, Smollett K, Simpson N, Wilson R, Yu J, et al. Identification of a novel Citrobacter rodentium type III secreted protein, EspI, and roles of this and other secreted proteins in infection. Infect Immun. 2004;72:2288-302 pubmed
    b>Citrobacter rodentium is a member of a group of pathogens that colonize the lumen of the host gastrointestinal tract via attaching and effacing (A/E) lesion formation. C...
  80. Richardson T, Sherman M, Kalman D, Morgan E. Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney. Drug Metab Dispos. 2006;34:351-3 pubmed
    ..and infection, mice were administered either saline or 1 mg/kg lipopolysaccharide (LPS) (16 h), or Citrobacter rodentium by oral gavage (6 days)...
  81. Lyte M, Li W, Opitz N, Gaykema R, Goehler L. Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium. Physiol Behav. 2006;89:350-7 pubmed
    ..In the present study, we utilized an animal model of IBD, infection with Citrobacter rodentium, to determine whether the infection per se can drive anxiety-like behavior...
  82. Ghosh S, Dai C, Brown K, Rajendiran E, Makarenko S, Baker J, et al. Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status, and ion transporter gene expression. Am J Physiol Gastrointest Liver Physiol. 2011;301:G39-49 pubmed publisher
    ..Previous studies have identified that C3H/HeOuJ mice suffer 100% mortality during Citrobacter rodentium-induced colitis, whereas C57BL/6 mice recover from infection...
  83. Dann S, Spehlmann M, Hammond D, Iimura M, Hase K, Choi L, et al. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol. 2008;180:6816-26 pubmed
    ..A murine infection model with one such pathogen, Citrobacter rodentium, was used to elucidate the importance of the pleiotropic immune regulator, IL-6, in the pathogenesis of ..
  84. Mundy R, MacDonald T, Dougan G, Frankel G, Wiles S. Citrobacter rodentium of mice and man. Cell Microbiol. 2005;7:1697-706 pubmed
    ..coli (EHEC) and Citrobacter rodentium, all of which use attaching and effacing (A/E) lesion formation as a major mechanism of tissue targeting ..
  85. Hansen K, Sherman P, Cellars L, Andrade Gordon P, Pan Z, Baruch A, et al. A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis. Proc Natl Acad Sci U S A. 2005;102:8363-8 pubmed
    b>Citrobacter rodentium is a bacterial pathogen that causes a murine infectious colitis equivalent to enterohemorrhagic Escherichia coli infection in humans. Colonic luminal fluid from C...
  86. Tennant S, Hartland E, Phumoonna T, Lyras D, Rood J, Robins Browne R, et al. Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens. Infect Immun. 2008;76:639-45 pubmed
    ..proton pump) gene were infected with Yersinia enterocolitica, Salmonella enterica serovar Typhimurium, Citrobacter rodentium, or Clostridium perfringens cells or spores...
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    ..coli, and Citrobacter rodentium. The LEE carries more than 40 genes that are arranged in several operons, e.g., LEE1 to LEE5...