deinococcus

Summary

Summary: A genus of gram-positive aerobic cocci found in the soil, that is highly resistant to radiation, especially ionizing radiation (RADIATION, IONIZING). Deinococcus radiodurans is the type species.

Top Publications

  1. Huang L, Hua X, Lu H, Gao G, Tian B, Shen B, et al. Three tandem HRDC domains have synergistic effect on the RecQ functions in Deinococcus radiodurans. DNA Repair (Amst). 2007;6:167-76 pubmed
    ..In Deinococcus radiodurans, DR1289 is a special member of RecQ family with unique arrangement of three tandem HRDC domains in ..
  2. Yuan M, Chen M, Zhang W, Lu W, Wang J, Yang M, et al. Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations. PLoS ONE. 2012;7:e34458 pubmed publisher
    ..We present here the complete genome and ultraviolet (UV) radiation-induced transcriptome of Deinococcus gobiensis I-0, which was isolated from the cold Gobi desert and shows higher tolerance to gamma radiation and ..
  3. Makharashvili N, Mi T, Koroleva O, Korolev S. RecR-mediated modulation of RecF dimer specificity for single- and double-stranded DNA. J Biol Chem. 2009;284:1425-34 pubmed publisher
    ..Here, we demonstrate that the RecF of Deinococcus radiodurans interacts with DNA as an ATP-dependent dimer, and that the DNA binding and ATPase activity of RecF ..
  4. Jena S, Joshi H, Sabareesh K, Tata B, Rao T. Dynamics of Deinococcus radiodurans under controlled growth conditions. Biophys J. 2006;91:2699-707 pubmed
    b>Deinococcus radiodurans is a potent radiation resistant bacterium with immense potential in nuclear waste treatment. In this investigation, the translational and rotational dynamics of dilute suspensions of D...
  5. Ghosh S, Grove A. The Deinococcus radiodurans-encoded HU protein has two DNA-binding domains. Biochemistry. 2006;45:1723-33 pubmed
    b>Deinococcus radiodurans can reconstitute its genome from double-strand breaks, most likely due to unusually efficient DNA repair and recombination. Factors that may contribute to such processes include the histone-like protein HU. The D...
  6. Servinsky M, Julin D. Effect of a recD mutation on DNA damage resistance and transformation in Deinococcus radiodurans. J Bacteriol. 2007;189:5101-7 pubmed
    The bacterium Deinococcus radiodurans is resistant to extremely high levels of DNA-damaging agents such as UV light, ionizing radiation, and chemicals such as hydrogen peroxide and mitomycin C...
  7. Baudet M, Ortet P, Gaillard J, Fernandez B, Guerin P, Enjalbal C, et al. Proteomics-based refinement of Deinococcus deserti genome annotation reveals an unwonted use of non-canonical translation initiation codons. Mol Cell Proteomics. 2010;9:415-26 pubmed publisher
    ..To achieve a comprehensive and accurate annotation of the Deinococcus deserti genome, we performed an N terminus-oriented characterization of its proteome...
  8. Huang L, Zhang S, Hua X, Gao G, Hua Y. [Construction of the recQ double mutants and analysis of adversity in Deinococcus radiodurans]. Wei Sheng Wu Xue Bao. 2006;46:205-9 pubmed
    ..b>Deinococcus radiodurans encodes two recQ genes with unusual domain: DR1289 and DR2444, whose functions, however, remain ..
  9. Wang W, Mao J, Zhang Z, Tang Q, Xie Y, Zhu J, et al. Deinococcus wulumuqiensis sp. nov., and Deinococcus xibeiensis sp. nov., isolated from radiation-polluted soil. Int J Syst Evol Microbiol. 2010;60:2006-10 pubmed publisher
    ..hybridizations showed that strains R12(T) and R13(T) are members of novel species belonging to the genus Deinococcus, with Deinococcus radiodurans DSM 20539(T) as the closest relative...

More Information

Publications154 found, 100 shown here

  1. Asker D, Awad T, Beppu T, Ueda K. Deinococcus misasensis and Deinococcus roseus, novel members of the genus Deinococcus, isolated from a radioactive site in Japan. Syst Appl Microbiol. 2008;31:43-9 pubmed
    ..lineage in the family Deinococcaceae, and the highest degrees of sequence similarity determined belonged to Deinococcus maricopensis LB-34T (88.8-89.3%), Deinococcus pimensis KR-235T (86.4-86...
  2. Kozlov A, Eggington J, Cox M, Lohman T. Binding of the dimeric Deinococcus radiodurans single-stranded DNA binding protein to single-stranded DNA. Biochemistry. 2010;49:8266-75 pubmed publisher
    b>Deinococcus radiodurans single-stranded (ss) DNA binding protein (DrSSB) originates from a radiation-resistant bacterium and participates in DNA recombination, replication, and repair...
  3. Khairnar N, Misra H. DNA polymerase X from Deinococcus radiodurans implicated in bacterial tolerance to DNA damage is characterized as a short patch base excision repair polymerase. Microbiology. 2009;155:3005-14 pubmed publisher
    The Deinococcus radiodurans R1 genome encodes an X-family DNA repair polymerase homologous to eukaryotic DNA polymerase beta...
  4. Heinz K, Marx A. Lesion bypass activity of DNA polymerase A from the extremely radioresistant organism Deinococcus radiodurans. J Biol Chem. 2007;282:10908-14 pubmed
    The bacterium Deinococcus radiodurans survives extremely high exposure to ionizing radiation and extended periods of desiccation...
  5. Bouthier de La Tour C, Toueille M, Jolivet E, Nguyen H, Servant P, Vannier F, et al. The Deinococcus radiodurans SMC protein is dispensable for cell viability yet plays a role in DNA folding. Extremophiles. 2009;13:827-37 pubmed publisher
    b>Deinococcus radiodurans contains a highly condensed nucleoid that remains to be unaltered following the exposure to high doses of gamma-irradiation...
  6. Kamble V, Rajpurohit Y, Srivastava A, Misra H. Increased synthesis of signaling molecules coincides with reversible inhibition of nucleolytic activity during postirradiation recovery of Deinococcus radiodurans. FEMS Microbiol Lett. 2010;303:18-25 pubmed publisher
    b>Deinococcus radiodurans tolerates extensive DNA damage and exhibits differential expression of various genes associated with the growth of the organism and DNA repair...
  7. Ngo K, Molzberger E, Chitteni Pattu S, Cox M. Regulation of Deinococcus radiodurans RecA protein function via modulation of active and inactive nucleoprotein filament states. J Biol Chem. 2013;288:21351-66 pubmed publisher
    The RecA protein of Deinococcus radiodurans (DrRecA) has a central role in genome reconstitution after exposure to extreme levels of ionizing radiation...
  8. Kampfer P, Lodders N, Huber B, Falsen E, Busse H. Deinococcus aquatilis sp. nov., isolated from water. Int J Syst Evol Microbiol. 2008;58:2803-6 pubmed publisher
    ..Analyses using the 16S rRNA gene sequence of the isolate showed that the organism belongs to the genus Deinococcus, with the highest sequence similarities to the type strains of Deinococcus ficus (94...
  9. Wagner J, Brunzelle J, Forest K, Vierstra R. A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome. Nature. 2005;438:325-31 pubmed publisher
    ..Here we describe the three-dimensional structure of the chromophore-binding domain of Deinococcus radiodurans phytochrome assembled with its chromophore biliverdin in the Pr ground state...
  10. Sghaier H, Narumi I, Satoh K, Ohba H, Mitomo H. Problems with the current deinococcal hypothesis: an alternative theory. Theory Biosci. 2007;126:43-5 pubmed
    All theories related to the evolution of Deinococcus radiodurans have a common denominator: the strong positive correlation between ionizing-radiation resistance and desiccation tolerance. Currently, the widespread hypothesis is that D...
  11. Shashidhar R, Bandekar J. Deinococcus piscis sp. nov., a radiation-resistant bacterium isolated from a marine fish. Int J Syst Evol Microbiol. 2009;59:2714-7 pubmed publisher
    ..9 %) with Deinococcus proteolyticus DSM 20540(T). The DeltaT(m) for DNA-DNA hybridization of D...
  12. Tian B, Sun Z, Shen S, Wang H, Jiao J, Wang L, et al. Effects of carotenoids from Deinococcus radiodurans on protein oxidation. Lett Appl Microbiol. 2009;49:689-94 pubmed publisher
    To evaluate the antioxidant effect of carotenoids from Deinococcus radiodurans on protein. Deinococcus radiodurans strain R1 (ATCC 13939) and its mutant strain R1DeltacrtB were used for this study. The total carotenoids (R1ex) from D...
  13. Blasius M, Shevelev I, Jolivet E, Sommer S, Hubscher U. DNA polymerase X from Deinococcus radiodurans possesses a structure-modulated 3'-->5' exonuclease activity involved in radioresistance. Mol Microbiol. 2006;60:165-76 pubmed
    Recently a family X DNA polymerase (PolXDr) was identified in the radioresistant bacterium Deinococcus radiodurans. Knockout cells show a delay in double-strand break repair (DSBR) and an increased sensitivity to gamma-irradiation...
  14. Yang Y, Itoh T, Yokobori S, Itahashi S, Shimada H, Satoh K, et al. Deinococcus aerius sp. nov., isolated from the high atmosphere. Int J Syst Evol Microbiol. 2009;59:1862-6 pubmed publisher
    ..Phylogenetic analysis based on 16S rRNA gene sequences showed that the strain was within the radiation of Deinococcus species. The major peptidoglycan amino acids were D-glutamic acid, glycine, D-alanine, L-alanine and ornithine...
  15. Joe M, Jung S, Im S, Lim S, Song H, Kwon O, et al. Genome-wide response of Deinococcus radiodurans on cadmium toxicity. J Microbiol Biotechnol. 2011;21:438-47 pubmed
    b>Deinococcus radiodurans is extremely resistant to various genotoxic conditions and chemicals. In this study, we characterized the effect of a sublethal concentration (100 microM) of cadmium (Cd) on D...
  16. Weon H, Kim B, Schumann P, Son J, Jang J, Go S, et al. Deinococcus cellulosilyticus sp. nov., isolated from air. Int J Syst Evol Microbiol. 2007;57:1685-8 pubmed
    ..The organism was found to have resistance to UV radiation typical of members of the genus Deinococcus, and it was placed within the radiation of the Deinococcus on a phylogenetic tree based on 16S rRNA gene ..
  17. Joe M, Lee K, Lim S, Im S, Song H, Lee I, et al. Pigment-based whole-cell biosensor system for cadmium detection using genetically engineered Deinococcus radiodurans. Bioprocess Biosyst Eng. 2012;35:265-72 pubmed publisher
    ..biosensor for cadmium (Cd) was designed using a genetically engineered red pigment producing bacterium, Deinococcus radiodurans...
  18. Gaidamakova E, Myles I, McDaniel D, Fowler C, Valdez P, Naik S, et al. Preserving immunogenicity of lethally irradiated viral and bacterial vaccine epitopes using a radio- protective Mn2+-Peptide complex from Deinococcus. Cell Host Microbe. 2012;12:117-124 pubmed publisher
    ..We demonstrate the use of a reconstituted manganous peptide complex from the radiation-resistant bacterium Deinococcus radiodurans to protect protein epitopes from radiation-induced damage and uncouple it from genome damage and ..
  19. Im S, Song D, Joe M, Kim D, Park D, Lim S. Comparative survival analysis of 12 histidine kinase mutants of Deinococcus radiodurans after exposure to DNA-damaging agents. Bioprocess Biosyst Eng. 2013;36:781-9 pubmed publisher
    ..b>Deinococcus radiodurans, one of the most resistant organisms to ionizing radiation, has 20 putative HKs and 25 putative RRs...
  20. Cox M, Battista J. Deinococcus radiodurans - the consummate survivor. Nat Rev Microbiol. 2005;3:882-92 pubmed
    Relatively little is known about the biochemical basis of the capacity of Deinococcus radiodurans to endure the genetic insult that results from exposure to ionizing radiation and can include hundreds of DNA double-strand breaks...
  21. Tian B, Sun Z, Xu Z, Shen S, Wang H, Hua Y. Carotenoid 3',4'-desaturase is involved in carotenoid biosynthesis in the radioresistant bacterium Deinococcus radiodurans. Microbiology. 2008;154:3697-706 pubmed publisher
    b>Deinococcus radiodurans strain R1 synthesizes deinoxanthin, a unique carotenoid product, which contributes to cell resistance following various stresses...
  22. Ohba H, Satoh K, Sghaier H, Yanagisawa T, Narumi I. Identification of PprM: a modulator of the PprI-dependent DNA damage response in Deinococcus radiodurans. Extremophiles. 2009;13:471-9 pubmed publisher
    b>Deinococcus radiodurans possesses a DNA damage response mechanism that acts via the PprI protein to induce RecA and PprA proteins, both of which are necessary in conferring extreme radioresistance...
  23. Leulliot N, Cladière L, Lecointe F, Durand D, Hubscher U, van Tilbeurgh H. The family X DNA polymerase from Deinococcus radiodurans adopts a non-standard extended conformation. J Biol Chem. 2009;284:11992-9 pubmed publisher
    b>Deinococcus radiodurans is an extraordinarily radioresistant bacterium that is able to repair hundreds of radiation-induced double-stranded DNA breaks. One of the players in this pathway is an X family DNA polymerase (PolX(Dr))...
  24. Ujaoney A, Potnis A, Kane P, Mukhopadhyaya R, Apte S. Radiation desiccation response motif-like sequences are involved in transcriptional activation of the Deinococcal ssb gene by ionizing radiation but not by desiccation. J Bacteriol. 2010;192:5637-44 pubmed publisher
    Single-stranded-DNA binding protein (SSB) levels during poststress recovery of Deinococcus radiodurans were significantly enhanced by (60)Co gamma rays or mitomycin C treatment but not by exposure to UV rays, hydrogen peroxide (H?O?), or ..
  25. Gao G, Lu H, Yin L, Hua Y. Ring-like nucleoid does not play a key role in radioresistance of Deinococcus radiodurans. Sci China C Life Sci. 2007;50:525-9 pubmed
    The conclusion based on transmission electron microscopy, "the tightly packed ring-like nucleoid of the Deinococcus radiodurans R1 is a key to radioresistance", has instigated lots of debates...
  26. Kota S, Kamble V, Rajpurohit Y, Misra H. ATP-type DNA ligase requires other proteins for its activity in vitro and its operon components for radiation resistance in Deinococcus radiodurans in vivo. Biochem Cell Biol. 2010;88:783-90 pubmed publisher
    A multiprotein DNA processing complex isolated from Deinococcus radiodurans contains the DNA repair protein PprA, an ATP-type DNA repair ligase (LigB) encoded by the drB0100 gene, and protein kinase activity...
  27. Hua X, Wang H, Wang C, Tian B, Hua Y. Global effect of an RNA polymerase ?-subunit mutation on gene expression in the radiation-resistant bacterium Deinococcus radiodurans. Sci China Life Sci. 2011;54:854-62 pubmed publisher
    ..acid replacement (L420R) and deletion (1258-66 9 bp deletion) have been previously isolated in the rpoB gene of Deinococcus radiodurans. In this study, a ?-subunit mutation in D. radiodurans resulted in a unique effect on growth rate...
  28. Daly M. Modulating radiation resistance: Insights based on defenses against reactive oxygen species in the radioresistant bacterium Deinococcus radiodurans. Clin Lab Med. 2006;26:491-504, x pubmed
    ..This article presents a new perspective on extreme IR resistance in the eubacterium Deinococcus radiodurans, reevaluates the role of superoxide (02*-) ions in IR toxicity, and speculates on potential ..
  29. Xu Z, Tian B, Sun Z, Lin J, Hua Y. Identification and functional analysis of a phytoene desaturase gene from the extremely radioresistant bacterium Deinococcus radiodurans. Microbiology. 2007;153:1642-52 pubmed
    ..The gene encoding phytoene desaturase in the deinoxanthin synthesis pathway of Deinococcus radiodurans was identified and characterized...
  30. Sukhi S, Shashidhar R, Kumar S, Bandekar J. Radiation resistance of Deinococcus radiodurans R1 with respect to growth phase. FEMS Microbiol Lett. 2009;297:49-53 pubmed publisher
    b>Deinococcus species exhibit an extraordinary ability to withstand ionizing radiation (IR). Most of the studies on radiation resistance have been carried out with exponential phase cells...
  31. Wu Y, Chen W, Zhao Y, Xu H, Hua Y. Involvement of RecG in H2O2-induced damage repair in Deinococcus radiodurans. Can J Microbiol. 2009;55:841-8 pubmed publisher
    b>Deinococcus radiodurans (ex Raj et al. 1960) Brooks and Murray 1981 is well known for its efficient repair of various types of physically or chemically induced DNA damage caused by ionizing and ultraviolet radiation or H2O2...
  32. Daly M, Gaidamakova E, Matrosova V, Kiang J, Fukumoto R, Lee D, et al. Small-molecule antioxidant proteome-shields in Deinococcus radiodurans. PLoS ONE. 2010;5:e12570 pubmed publisher
    For Deinococcus radiodurans and other bacteria which are extremely resistant to ionizing radiation, ultraviolet radiation, and desiccation, a mechanistic link exists between resistance, manganese accumulation, and protein protection...
  33. Desai S, Rajpurohit Y, Misra H, Deobagkar D. Characterization of the role of the RadS/RadR two-component system in the radiation resistance of Deinococcus radiodurans. Microbiology. 2011;157:2974-82 pubmed publisher
    b>Deinococcus radiodurans shows extraordinary tolerance to DNA damage, and exhibits differential gene expression and protein recycling...
  34. Kim J. Analysis of double stranded DNA-dependent activities of Deinococcus radiodurans RecA protein. J Microbiol. 2006;44:508-14 pubmed
    In this study, the double-stranded DNA-dependent activities of Deinococcus radiodurans RecA protein (Dr RecA) were characterized...
  35. Havelund J, Giessing A, Hansen T, Rasmussen A, Scott L, Kirpekar F. Identification of 5-hydroxycytidine at position 2501 concludes characterization of modified nucleotides in E. coli 23S rRNA. J Mol Biol. 2011;411:529-36 pubmed publisher
    ..we show that 5-hydroxycytidine is also present in the equivalent position of 23S rRNA from the bacterium Deinococcus radiodurans...
  36. Yoo S, Weon H, Kim S, Kim Y, Kim B, Kwon S. Deinococcus aerolatus sp. nov. and Deinococcus aerophilus sp. nov., isolated from air samples. Int J Syst Evol Microbiol. 2010;60:1191-5 pubmed publisher
    ..Phylogenetic analyses using 16S rRNA gene sequences showed that both novel strains were affiliated to the genus Deinococcus. Strain 5516T-9(T) exhibited the highest sequence similarity with Deinococcus marmoris DSM 12784(T) (96...
  37. Obiero J, Pittet V, Bonderoff S, Sanders D. Thioredoxin system from Deinococcus radiodurans. J Bacteriol. 2010;192:494-501 pubmed publisher
    ..reductase (TrxR) and the structure determination of TrxR from the ionizing radiation-tolerant bacterium Deinococcus radiodurans strain R1. The genes from D...
  38. Maisch T, Shimizu T, Mitra A, Heinlin J, Karrer S, Li Y, et al. Contact-free cold atmospheric plasma treatment of Deinococcus radiodurans. J Ind Microbiol Biotechnol. 2012;39:1367-75 pubmed publisher
    In this study we investigated the sensitivity of Deinococcus radiodurans to contact-free cold atmospheric plasma treatment as part of a project to establish new efficient procedures for disinfection of inanimate surfaces...
  39. Fisher D, Cartwright J, McLennan A. Characterization of the Mn2+-stimulated (di)adenosine polyphosphate hydrolase encoded by the Deinococcus radiodurans DR2356 nudix gene. Arch Microbiol. 2006;186:415-24 pubmed
    The DR2356 nudix hydrolase gene from Deinococcus radiodurans has been cloned and the product expressed as an 18 kDa histidine-tagged protein...
  40. Lu H, Gao G, Xu G, Fan L, Yin L, Shen B, et al. Deinococcus radiodurans PprI switches on DNA damage response and cellular survival networks after radiation damage. Mol Cell Proteomics. 2009;8:481-94 pubmed publisher
    ..of recA and other DNA repair genes in response to DNA damage in the extremely radioresistant bacterium Deinococcus radiodurans...
  41. Seo H, Lee Y. Characterization of Deinococcus radiophilus thioredoxin reductase active with both NADH and NADPH. J Microbiol. 2010;48:637-43 pubmed publisher
    Thioredoxin reductase (TrxR, EC 1.6.4.5) of Deinococcus radiophilus was purified by steps of sonication, ammonium sulfate fractionation, 2'5' ADP Sepharose 4B affinity chromatography, and Sephadex G-100 gel filtration...
  42. Li H, Zhang J, Vierstra R, Li H. Quaternary organization of a phytochrome dimer as revealed by cryoelectron microscopy. Proc Natl Acad Sci U S A. 2010;107:10872-7 pubmed publisher
    ..determine the quaternary arrangement of the phytochrome dimer as Pr, using the bacteriophytochrome (BphP) from Deinococcus radiodurans...
  43. Lu H, Chen H, Xu G, Shah A, Hua Y. DNA binding is essential for PprI function in response to radiation damage in Deinococcus radiodurans. DNA Repair (Amst). 2012;11:139-45 pubmed publisher
    The extremely radioresistant bacterium Deinococcus radiodurans possesses a rapid and efficient but poorly known DNA damage response mechanism that mobilizes one-third of its genome to survive lethal radiation damage...
  44. Reece S, Woodward J, Marletta M. Synthesis of nitric oxide by the NOS-like protein from deinococcus radiodurans: a direct role for tetrahydrofolate. Biochemistry. 2009;48:5483-91 pubmed publisher
    ..The NOS gene from one such bacterium, Deinococcus radiodurans, was cloned and expressed (deiNOS) in Escherichia coli and then purified and characterized...
  45. Hsu H, Ngo K, Chitteni Pattu S, Cox M, Li H. Investigating Deinococcus radiodurans RecA protein filament formation on double-stranded DNA by a real-time single-molecule approach. Biochemistry. 2011;50:8270-80 pubmed publisher
    With the aid of an efficient, precise, and almost error-free DNA repair system, Deinococcus radiodurans can survive hundreds of double-strand breaks inflicted by high doses of irradiation or desiccation. RecA of D...
  46. Kobayashi I, Tamura T, Sghaier H, Narumi I, Yamaguchi S, Umeda K, et al. Characterization of monofunctional catalase KatA from radioresistant bacterium Deinococcus radiodurans. J Biosci Bioeng. 2006;101:315-21 pubmed publisher
    ..purification and characterization of a catalase (KatA, DR1998) from the extremely radioresistant bacterium Deinococcus radiodurans. The size of purified D...
  47. Jiao J, Wang L, Xia W, Li M, Sun H, Xu G, et al. Function and biochemical characterization of RecJ in Deinococcus radiodurans. DNA Repair (Amst). 2012;11:349-56 pubmed publisher
    ..DSBs repair mainly occurs via the RecFOR pathway in Deinococcus radiodurans, a well-known radiation-resistant bacterium...
  48. Gao G, Le D, Huang L, Lu H, Narumi I, Hua Y. Internal promoter characterization and expression of the Deinococcus radiodurans pprI-folP gene cluster. FEMS Microbiol Lett. 2006;257:195-201 pubmed
    PprI is a general gene switch responsible for the extraordinary radioresistance of Deinococcus radiodurans...
  49. Cao Z, Julin D. Characterization in vitro and in vivo of the DNA helicase encoded by Deinococcus radiodurans locus DR1572. DNA Repair (Amst). 2009;8:612-9 pubmed publisher
    b>Deinococcus radiodurans survives extremely high doses of ionizing and ultraviolet radiation and treatment with various DNA-damaging chemicals...
  50. Wagner J, Zhang J, von Stetten D, Günther M, Murgida D, Mroginski M, et al. Mutational analysis of Deinococcus radiodurans bacteriophytochrome reveals key amino acids necessary for the photochromicity and proton exchange cycle of phytochromes. J Biol Chem. 2008;283:12212-26 pubmed publisher
    ..spectroscopic methods, we examined the roles of conserved amino acids within the bilin-binding domain of Deinococcus radiodurans bacteriophytochrome with respect to chromophore ligation and Pr/Pfr photoconversion...
  51. Shashidhar R, Kumar S, Misra H, Bandekar J. Evaluation of the role of enzymatic and nonenzymatic antioxidant systems in the radiation resistance of Deinococcus. Can J Microbiol. 2010;56:195-201 pubmed publisher
    ..different roles in the oxidative stress resistance responses of radiation-resistant bacteria belonging to the Deinococcus-Thermus group...
  52. Koroleva O, Makharashvili N, Courcelle C, Courcelle J, Korolev S. Structural conservation of RecF and Rad50: implications for DNA recognition and RecF function. EMBO J. 2007;26:867-77 pubmed
    ..Here, we present the crystal structure of RecF from Deinococcus radiodurans...
  53. Im W, Jung H, Ten L, Kim M, Bora N, Goodfellow M, et al. Deinococcus aquaticus sp. nov., isolated from fresh water, and Deinococcus caeni sp. nov., isolated from activated sludge. Int J Syst Evol Microbiol. 2008;58:2348-53 pubmed publisher
    ..and non-spore-forming and had chemotaxonomic properties consistent with their classification in the genus Deinococcus 16S rRNA gene tree, the highest sequence similarities being shown to the type strains of Deinococcus grandis (..
  54. Rajpurohit Y, Misra H. Characterization of a DNA damage-inducible membrane protein kinase from Deinococcus radiodurans and its role in bacterial radioresistance and DNA strand break repair. Mol Microbiol. 2010;77:1470-82 pubmed publisher
    b>Deinococcus radiodurans mutant lacking pyrroloquinoline-quinone (PQQ) synthesis shows sensitivity to ?-rays and impairment of DNA double strand break repair...
  55. Tian B, Hua Y. Carotenoid biosynthesis in extremophilic Deinococcus-Thermus bacteria. Trends Microbiol. 2010;18:512-20 pubmed publisher
    Bacteria from the phylum Deinococcus-Thermus are known for their resistance to extreme stresses including radiation, oxidation, desiccation and high temperature...
  56. Bentchikou E, Servant P, Coste G, Sommer S. Additive effects of SbcCD and PolX deficiencies in the in vivo repair of DNA double-strand breaks in Deinococcus radiodurans. J Bacteriol. 2007;189:4784-90 pubmed
    ..Here, we have inactivated the sbcC and/or sbcD genes of Deinococcus radiodurans, a highly radioresistant bacterium able to mend hundreds of radiation-induced DNA double-strand ..
  57. Xu G, Wang L, Chen H, Lu H, Ying N, Tian B, et al. RecO is essential for DNA damage repair in Deinococcus radiodurans. J Bacteriol. 2008;190:2624-8 pubmed publisher
    Here we present direct evidence for the vital role of RecO in Deinococcus radiodurans's radioresistance. A recO null mutant was constructed using a deletion replacement method...
  58. Bauermeister A, Bentchikou E, Moeller R, Rettberg P. Roles of PprA, IrrE, and RecA in the resistance of Deinococcus radiodurans to germicidal and environmentally relevant UV radiation. Arch Microbiol. 2009;191:913-8 pubmed publisher
    To study the role of different DNA repair genes in the resistance of Deinococcus radiodurans to mono- and polychromatic UV radiation, wild-type strain and knockout mutants in RecA, PprA, and IrrE of D...
  59. Guérin F, Barbe S, Pizzut Serin S, Potocki Veronese G, Guieysse D, Guillet V, et al. Structural investigation of the thermostability and product specificity of amylosucrase from the bacterium Deinococcus geothermalis. J Biol Chem. 2012;287:6642-54 pubmed publisher
    ..We report the first structures of the amylosucrases from Deinococcus geothermalis and Neisseria polysaccharea in complex with turanose. In the amylosucrase from N...
  60. Armengaud J. A perfect genome annotation is within reach with the proteomics and genomics alliance. Curr Opin Microbiol. 2009;12:292-300 pubmed publisher
    ..can be carried out at the earliest stage of the genome project as already exemplified by Mycoplasma mobile and Deinococcus deserti genomes...
  61. Chang S, Shu H, Li Z, Wang Y, Chen L, Hua Y, et al. Disruption of manganese ions [Mn(II)] transporter genes DR1709 or DR2523 in extremely radio-resistant bacterium Deinococcus radiodurans. Wei Sheng Wu Xue Bao. 2009;49:438-44 pubmed
    ..study was to identify whether the manganese ions [Mn(II)] transporter genes DR1709 and DR2523 played roles in Deinococcus radiodurans's radiation resistance...
  62. Saarimaa C, Peltola M, Raulio M, Neu T, Salkinoja Salonen M, Neubauer P. Characterization of adhesion threads of Deinococcus geothermalis as type IV pili. J Bacteriol. 2006;188:7016-21 pubmed
    b>Deinococcus geothermalis E50051 forms tenuous biofilms on paper machine surfaces...
  63. Wang L, Xu G, Chen H, Zhao Y, Xu N, Tian B, et al. DrRRA: a novel response regulator essential for the extreme radioresistance of Deinococcus radiodurans. Mol Microbiol. 2008;67:1211-22 pubmed publisher
    ..a response regulator (we designate it drRRA) is identified to be essential for the extreme radioresistance of Deinococcus radiodurans...
  64. Fredrickson J, Li S, Gaidamakova E, Matrosova V, Zhai M, Sulloway H, et al. Protein oxidation: key to bacterial desiccation resistance?. ISME J. 2008;2:393-403 pubmed publisher
    ..The majority of isolates were closely related to members of the genus Deinococcus, with Chelatococcus, Methylobacterium and Bosea also among the genera identified...
  65. Daly M. A new perspective on radiation resistance based on Deinococcus radiodurans. Nat Rev Microbiol. 2009;7:237-45 pubmed publisher
    ..This would allow an irradiated cell to protect sufficient enzymatic activity needed to repair DNA and survive. ..
  66. Sugiman Marangos S, Junop M. The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteins. Nucleic Acids Res. 2010;38:3432-40 pubmed publisher
    b>Deinococcus spp. are renowned for their amazing ability to recover rapidly from severe genomic fragmentation as a result of exposure to extreme levels of ionizing radiation or desiccation...
  67. Misra H, Khairnar N, Kota S, Shrivastava S, Joshi V, Apte S. An exonuclease I-sensitive DNA repair pathway in Deinococcus radiodurans: a major determinant of radiation resistance. Mol Microbiol. 2006;59:1308-16 pubmed
    b>Deinococcus radiodurans R1 recovering from acute dose of gamma radiation shows a biphasic mechanism of DNA double-strand break repair...
  68. Abreu I, Hearn A, An H, Nick H, Silverman D, Cabelli D. The kinetic mechanism of manganese-containing superoxide dismutase from Deinococcus radiodurans: a specialized enzyme for the elimination of high superoxide concentrations. Biochemistry. 2008;47:2350-6 pubmed publisher
    b>Deinococcus radiodurans (Drad), a bacterium with an extraordinary capacity to tolerate high levels of ionizing radiation, produces only a manganese-containing superoxide dismutase (MnSOD)...
  69. Cuypers M, Mitchell E, Romão C, McSweeney S. The crystal structure of the Dps2 from Deinococcus radiodurans reveals an unusual pore profile with a non-specific metal binding site. J Mol Biol. 2007;371:787-99 pubmed
    ..DNA protecting protein under starved conditions) from the Gram-positive, radiation-resistant bacterium Deinococcus radiodurans has been determined in its apo and iron loaded states...
  70. Schlesinger D. Role of RecA in DNA damage repair in Deinococcus radiodurans. FEMS Microbiol Lett. 2007;274:342-7 pubmed
    It has been shown previously that the RecA protein of Deinococcus radiodurans plays a unique role in the repair of DNA damage in this highly DNA damage-resistant organism...
  71. Griffiths E, Gupta R. Identification of signature proteins that are distinctive of the Deinococcus-Thermus phylum. Int Microbiol. 2007;10:201-8 pubmed
    The members of the Deinococcus-Thermus phylum, which include many species that are resistant to extreme radiation, as well as several thermophiles, have been recognized solely on the basis of their branching patterns in 16S rRNA and ..
  72. Toueille M, Mirabella B, Guerin P, Bouthier de La Tour C, Boisnard S, Nguyen H, et al. A comparative proteomic approach to better define Deinococcus nucleoid specificities. J Proteomics. 2012;75:2588-600 pubmed publisher
    Compared to radiation-sensitive bacteria, the nucleoids of radiation-resistant Deinococcus species show a higher degree of compaction...
  73. de La Tour C, Passot F, Toueille M, Mirabella B, Guerin P, Blanchard L, et al. Comparative proteomics reveals key proteins recruited at the nucleoid of Deinococcus after irradiation-induced DNA damage. Proteomics. 2013;13:3457-69 pubmed publisher
    The nucleoids of radiation-resistant Deinococcus species show a high degree of compaction maintained after ionizing irradiation...
  74. Tian B, Xu Z, Sun Z, Lin J, Hua Y. Evaluation of the antioxidant effects of carotenoids from Deinococcus radiodurans through targeted mutagenesis, chemiluminescence, and DNA damage analyses. Biochim Biophys Acta. 2007;1770:902-11 pubmed
    b>Deinococcus radiodurans is highly resistant to reactive oxygen species (ROS). The antioxidant effect of carotenoids in D...
  75. Vujicic Zagar A, Dulermo R, Le Gorrec M, Vannier F, Servant P, Sommer S, et al. Crystal structure of the IrrE protein, a central regulator of DNA damage repair in deinococcaceae. J Mol Biol. 2009;386:704-16 pubmed publisher
    Deinococcaceae are famous for their extreme radioresistance. Transcriptome analysis in Deinococcus radiodurans revealed a group of genes up-regulated in response to desiccation and ionizing radiation...
  76. Miropolskaya N, Artsimovitch I, Klimasauskas S, Nikiforov V, Kulbachinskiy A. Allosteric control of catalysis by the F loop of RNA polymerase. Proc Natl Acad Sci U S A. 2009;106:18942-7 pubmed publisher
    ..RNAP from thermophilic Thermus aquaticus is dramatically reduced compared with its closest mesophilic relative, Deinococcus radiodurans...
  77. Sun H, Xu G, Zhan H, Chen H, Sun Z, Tian B, et al. Identification and evaluation of the role of the manganese efflux protein in Deinococcus radiodurans. BMC Microbiol. 2010;10:319 pubmed publisher
    b>Deinococcus radiodurans accumulates high levels of manganese ions, and this is believed to be correlated with the radiation resistance ability of this microorganism. However, the maintenance of manganese ion homeostasis in D...
  78. Zeng Y, Shen F, Tan C, Huang C, Young C. The flexibility of UV-inducible mutation in Deinococcus ficus as evidenced by the existence of the imuB-dnaE2 gene cassette and generation of superior feather degrading bacteria. Microbiol Res. 2011;167:40-7 pubmed publisher
    ..But it was previously thought that TLS polymerase activity was unlikely to exist in the radio-resistant genus Deinococcus. In our preliminary studies, the lexA-imuB-dnaE2 gene cassette was found in a newly isolated feather-degrading ..
  79. Saikrishnan K, Powell B, Cook N, Webb M, Wigley D. Mechanistic basis of 5'-3' translocation in SF1B helicases. Cell. 2009;137:849-59 pubmed publisher
    ..We present crystal structures of the complex between the SF1B helicase RecD2 from Deinococcus radiodurans and ssDNA in the presence and absence of an ATP analog...
  80. Lockhart J, DeVeaux L. The essential role of the Deinococcus radiodurans ssb gene in cell survival and radiation tolerance. PLoS ONE. 2013;8:e71651 pubmed publisher
    ..The genome of the extremely radiation resistant bacterium Deinococcus radiodurans contains genes for two SSB homologs: the homodimeric, canonical Ssb, encoded by the gene ssb, and a ..
  81. de Groot A, Dulermo R, Ortet P, Blanchard L, Guerin P, Fernandez B, et al. Alliance of proteomics and genomics to unravel the specificities of Sahara bacterium Deinococcus deserti. PLoS Genet. 2009;5:e1000434 pubmed publisher
    ..in hot arid deserts, we report the first complete genome sequence and proteome analysis of a bacterium, Deinococcus deserti VCD115, isolated from Sahara surface sand. Its genome consists of a 2...
  82. Zhou Q, Zhang X, Xu H, Xu B, Hua Y. A new role of Deinococcus radiodurans RecD in antioxidant pathway. FEMS Microbiol Lett. 2007;271:118-25 pubmed
    In Deinococcus radiodurans, RecBCD holoenzyme is not intact because of the absence of RecB and RecC, but a RecD-like protein does indeed exist. In this work, D...
  83. Nguyen H, de La Tour C, Toueille M, Vannier F, Sommer S, Servant P. The essential histone-like protein HU plays a major role in Deinococcus radiodurans nucleoid compaction. Mol Microbiol. 2009;73:240-52 pubmed publisher
    ..radiodurans. ..
  84. Diaz B, Schulze Makuch D. Microbial survival rates of Escherichia coli and Deinococcus radiodurans under low temperature, low pressure, and UV-Irradiation conditions, and their relevance to possible Martian life. Astrobiology. 2006;6:332-47 pubmed
    Viability rates were determined for microbial populations of Escherichia coli and Deinococcus radiodurans under the environmental stresses of low temperature (-35 degrees C), low-pressure conditions (83...
  85. Brim H, Osborne J, Kostandarithes H, Fredrickson J, Wackett L, Daly M. Deinococcus radiodurans engineered for complete toluene degradation facilitates Cr(VI) reduction. Microbiology. 2006;152:2469-77 pubmed
    ..In this study, the extremely radiation-resistant bacterium Deinococcus radiodurans, which naturally reduces Cr(VI) to the less mobile and less toxic Cr(III), was engineered for ..
  86. Appukuttan D, Rao A, Apte S. Engineering of Deinococcus radiodurans R1 for bioprecipitation of uranium from dilute nuclear waste. Appl Environ Microbiol. 2006;72:7873-8 pubmed
    ..We have constructed a Deinococcus radiodurans strain harboring phoN, a gene encoding a nonspecific acid phosphatase, obtained from a local ..
  87. Rajpurohit Y, Gopalakrishnan R, Misra H. Involvement of a protein kinase activity inducer in DNA double strand break repair and radioresistance of Deinococcus radiodurans. J Bacteriol. 2008;190:3948-54 pubmed publisher
    ..b>Deinococcus radiodurans R1 encodes an active pyrroloquinoline quinone synthase, and constitutive synthesis of ..
  88. Yang Y, Itoh T, Yokobori S, Shimada H, Itahashi S, Satoh K, et al. Deinococcus aetherius sp. nov., isolated from the stratosphere. Int J Syst Evol Microbiol. 2010;60:776-9 pubmed publisher
    ..Phylogenetic analysis based on 16S rRNA gene sequences showed that it belonged to the genus Deinococcus. DNA G+C content (69...
  89. Satoh K, Kikuchi M, Ishaque A, Ohba H, Yamada M, Tejima K, et al. The role of Deinococcus radiodurans RecFOR proteins in homologous recombination. DNA Repair (Amst). 2012;11:410-8 pubmed publisher
    b>Deinococcus radiodurans exhibits extraordinary resistance to the lethal effect of DNA-damaging agents, a characteristic attributed to its highly proficient DNA repair capacity. Although the D...
  90. Lim S, Song D, Joe M, Kim D. Development of a qualitative dose indicator for gamma radiation using lyophilized Deinococcus. J Microbiol Biotechnol. 2012;22:1296-300 pubmed
    The feasibility of using Deinococcus showing strong resistance to both desiccation and ionizing radiation as a dose indicator of gamma radiation exposure was evaluated...
  91. Sharma A, Gaidamakova E, Matrosova V, Bennett B, Daly M, Hoffman B. Responses of Mn2+ speciation in Deinococcus radiodurans and Escherichia coli to ?-radiation by advanced paramagnetic resonance methods. Proc Natl Acad Sci U S A. 2013;110:5945-50 pubmed publisher
    The remarkable ability of bacterium Deinococcus radiodurans to survive extreme doses of ?-rays (12,000 Gy), 20 times greater than Escherichia coli, is undiminished by loss of Mn-dependent superoxide dismutase (SodA). D...
  92. Mennecier S, Servant P, Coste G, Bailone A, Sommer S. Mutagenesis via IS transposition in Deinococcus radiodurans. Mol Microbiol. 2006;59:317-25 pubmed
    ..of the complete genome indicates that insertion sequences (ISs) are abundant in the radio-resistant bacterium Deinococcus radiodurans. By developing a forward mutagenesis assay to detect any inactivation events in D...