actinobacillus suis

Summary

Summary: A species of gram-negative bacteria in the genus ACTINOBACILLUS. It is mainly a pathogen of PIGS, but also can infect HORSES.

Top Publications

  1. Rullo A, Papp Szabo E, Michael F, Macinnes J, Monteiro M. The structural basis for the serospecificity of Actinobacillus suis serogroup O:2. Biochem Cell Biol. 2006;84:184-90 pubmed
    b>Actinobacillus suis is an important bacterial pathogen of healthly pigs...
  2. Lillie B, Hammermueller J, MacInnes J, Jacques M, Hayes M. Porcine mannan-binding lectin A binds to Actinobacillus suis and Haemophilus parasuis. Dev Comp Immunol. 2006;30:954-65 pubmed
    ..that bind in a carbohydrate-dependent manner to surfaces of important bacterial pig pathogens including Actinobacillus suis (AS), A. pleuropneumoniae (APP), and Haemophilus parasuis (HP). A plasma protein with 32kDa subunits (pI 5...
  3. MacInnes J, Gottschalk M, Lone A, Metcalf D, Ojha S, Rosendal T, et al. Prevalence of Actinobacillus pleuropneumoniae, Actinobacillus suis, Haemophilus parasuis, Pasteurella multocida, and Streptococcus suis in representative Ontario swine herds. Can J Vet Res. 2008;72:242-8 pubmed
    ..At least 16% and possibly as many as 94% of the herds tested were Actinobacillus suis positive; only 3 of the 50 herds were both A. pleuropneumoniae and A...
  4. Brockmeier S, Loving C, Palmer M, Spear A, Nicholson T, Faaberg K, et al. Comparison of Asian porcine high fever disease isolates of porcine reproductive and respiratory syndrome virus to United States isolates for their ability to cause disease and secondary bacterial infection in swine. Vet Microbiol. 2017;203:6-17 pubmed publisher
    ..strains (SDSU73 or VR-2332) alone or in combination with Streptococcus suis, Haemophilus parasuis, and Actinobacillus suis. Pigs infected with rJXwn06 exhibited the most severe clinical disease while the pigs infected with rSRV07 ..
  5. Bujold A, MacInnes J. Identification of putative adhesins of Actinobacillus suis and their homologues in other members of the family Pasteurellaceae. BMC Res Notes. 2015;8:675 pubmed publisher
    b>Actinobacillus suis disease has been reported in a wide range of vertebrate species, but is most commonly found in swine. A...
  6. Curran D, Adamiak P, Fegan J, Qian C, Yu R, Schryvers A. Sequence and structural diversity of transferrin receptors in Gram-negative porcine pathogens. Vaccine. 2015;33:5700-5707 pubmed publisher
    Actinobacillus pleuropneumoniae, Actinobacillus suis, and Haemophilus parasuis are bacterial pathogens from the upper respiratory tract that are responsible for a substantial burden of porcine disease...
  7. Bujold A, Labrie J, Jacques M, MacInnes J. Differential expression of putative adhesin genes of Actinobacillus suis grown in in vivo-like conditions. Vet Microbiol. 2016;195:60-69 pubmed publisher
    b>Actinobacillus suis is an opportunistic pathogen that resides in the tonsils of the soft palate of swine. Unknown stimuli can cause this organism to invade the host, resulting in septicaemia and sequelae including death...
  8. Bowring B, Fahy V, Morris A, Collins A. An unusual culprit: Klebsiella pneumoniae causing septicaemia outbreaks in neonatal pigs?. Vet Microbiol. 2017;203:267-270 pubmed publisher
    ..coli and beta-haemolytic streptococci. Infrequent causes of septicaemia are Actinobacillus suis and Citrobacter freundii...
  9. Bujold A, MacInnes J. Attachment of Actinobacillus suis H91-0380 and Its Isogenic Adhesin Mutants to Extracellular Matrix Components of the Tonsils of the Soft Palate of Swine. Infect Immun. 2016;84:2944-52 pubmed publisher
    ..b>Actinobacillus suis is a common resident of the tonsils of the soft palate in pigs, but under certain circumstances it can ..

More Information

Publications24

  1. Calmettes C, Yu R, Silva L, Curran D, Schriemer D, Schryvers A, et al. Structural variations within the transferrin binding site on transferrin-binding protein B, TbpB. J Biol Chem. 2011;286:12683-92 pubmed publisher
  2. Silva L, Yu R, Calmettes C, Yang X, Moraes T, Schryvers A, et al. Conserved interaction between transferrin and transferrin-binding proteins from porcine pathogens. J Biol Chem. 2011;286:21353-60 pubmed publisher
    ..Together, our findings support a model whereby TbpB efficiently captures and presents iron-loaded pTf to other elements of the uptake pathway, even under low iron conditions...
  3. Ojha S, Lacouture S, Gottschalk M, MacInnes J. Characterization of colonization-deficient mutants of Actinobacillus suis. Vet Microbiol. 2010;140:122-30 pubmed publisher
    b>Actinobacillus suis is an important opportunistic pathogen of swine that can cause disease in pigs of all ages, especially in high-health status herds. Although A...
  4. Mauch C, Bilkei G. Actinobacillus suis, a potential cause of abortion in gilts and low parity sows. Vet J. 2004;168:186-7 pubmed
  5. Negrete Abascal E, Pacheco S, Paniagua G, Méndez A, Caballero J, Márquez V, et al. Metalloproteases secreted by Actinobacillus suis. Curr Microbiol. 2004;49:55-8 pubmed
    b>Actinobacillus suis secretes metalloproteases into its medium...
  6. Kariyawasam S, Strait E, Jordan D, Kroll J. Development of a real-time polymerase chain reaction assay for detection of Actinobacillus suis in porcine lung. J Vet Diagn Invest. 2011;23:885-9 pubmed publisher
    ..of a real-time polymerase chain reaction (PCR) assay using a TaqMan-labeled probe for the detection of Actinobacillus suis from porcine lung samples is described...
  7. Ojha S, Hayes M, Turner P, MacInnes J. An experimental model of Actinobacillus suis infection in mice. Comp Med. 2007;57:340-8 pubmed
    b>Actinobacillus suis is an opportunistic pathogen of high health status swine and is associated with fatal septicemia, especially in neonatal pigs. A practical model of A. suis is unavailable currently...
  8. Ojha S, Sirois M, MacInnes J. Identification of Actinobacillus suis genes essential for the colonization of the upper respiratory tract of swine. Infect Immun. 2005;73:7032-9 pubmed
    b>Actinobacillus suis has emerged as an important opportunistic pathogen of high-health-status swine...
  9. Woldehiwet Z. Actinobacillus suis abortion: a possible cause for concern in pigs. Vet J. 2004;168:116-7 pubmed
  10. Deutschmann R, Boncheff A, Daraban L, MacInnes J, Monteiro M. Common sialylated glycan in Actinobacillus suis. Glycobiology. 2010;20:1227-32 pubmed publisher
    ..oligosaccharide was identified in four representative strains of the Gram-negative swine pathogen, Actinobacillus suis. As characterized, the glycan consists of a free oligosaccharide with a N-acetyl-lactosamine-like backbone ..
  11. Cheung Q, Turner P, Song C, Wu D, Cai H, MacInnes J, et al. Enhanced resistance to bacterial infection in protegrin-1 transgenic mice. Antimicrob Agents Chemother. 2008;52:1812-9 pubmed publisher
    ..on the production of transgenic mice that ectopically expressed PG-1 and compare their susceptibilities to Actinobacillus suis infection with those of their wild-type (WT) littermates. Of the 126 mice that were challenged with A...
  12. Deutschmann R, Boncheff A, MacInnes J, Monteiro M. Discovery and characterization of a fructosylated capsule polysaccharide and sialylated lipopolysaccharide in a virulent strain of Actinobacillus suis. Biochem Cell Biol. 2011;89:325-31 pubmed publisher
    We are developing a serotyping system for Actinobacillus suis based on its capsule (K) and lipopolysaccharide O-chain (O) structures...
  13. Ganeshapillai J, Boncheff A, Slavic D, Macinnes J, Monteiro M. The lipopolysaccharide core of Actinobacillus suis and its relationship to those of Actinobacillus pleuropneumoniae. Biochem Cell Biol. 2011;89:351-8 pubmed publisher
    The Gram-negative bacteria Actinobacillus suis colonizes the upper respiratory and genital tracts of swine. Along with capsular polysaccharides, lipopolysaccharides (O-chain?core?lipid A~cell) are a main cell-surface component of A...
  14. MacInnes J, Mackinnon J, Bujold A, Ziebell K, Kropinski A, Nash J. Complete genome sequence of Actinobacillus suis H91-0380, a virulent serotype O2 strain. J Bacteriol. 2012;194:6686-7 pubmed publisher
    Here, we report the first complete genome sequence of Actinobacillus suis, an important opportunistic pathogen of swine. By comparing the genome sequence of A...
  15. Bahrami F, Niven D. Iron acquisition by Actinobacillus suis: identification and characterization of a single-component haemoglobin receptor and encoding gene. Microb Pathog. 2005;39:45-51 pubmed
    b>Actinobacillus suis is an important swine pathogen. As with other pathogens, the ability of A. suis to acquire iron within the host is crucial for virulence. Here, we investigated the ability of seven strains of A...