actinobacillus pleuropneumoniae

Summary

Summary: A species of gram-negative, facultatively anaerobic coccobacillus-shaped bacteria that has been isolated from pneumonic lesions and blood. It produces pneumonia with accompanying fibrinous pleuritis in swine.

Top Publications

  1. Marois C, Cariolet R, Morvan H, Kobisch M. Transmission of pathogenic respiratory bacteria to specific pathogen free pigs at slaughter. Vet Microbiol. 2008;129:325-32 pubmed publisher
    ..Five bacterial pathogens (Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis and Streptococcus suis) were detected by PCR, after ..
  2. Li L, Zhou R, Li T, Kang M, Wan Y, Xu Z, et al. Enhanced biofilm formation and reduced virulence of Actinobacillus pleuropneumoniae luxS mutant. Microb Pathog. 2008;45:192-200 pubmed publisher
    b>Actinobacillus pleuropneumoniae is the pathogen of porcine contagious pleuropneumonia causing great economic losses globally...
  3. Subashchandrabose S, Leveque R, Wagner T, Kirkwood R, Kiupel M, Mulks M. Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine. Infect Immun. 2009;77:4925-33 pubmed publisher
    In Actinobacillus pleuropneumoniae, which causes porcine pleuropneumonia, ilvI was identified as an in vivo-induced (ivi) gene and encodes the enzyme acetohydroxyacid synthase (AHAS) required for branched-chain amino acid (BCAA) ..
  4. Schwarz F, Fan Y, Schubert M, Aebi M. Cytoplasmic N-glycosyltransferase of Actinobacillus pleuropneumoniae is an inverting enzyme and recognizes the NX(S/T) consensus sequence. J Biol Chem. 2011;286:35267-74 pubmed publisher
    ..The identification of an enzyme that integrates some of the features of OST in a cytoplasmic pathway defines a novel class of N-linked protein glycosylation found in pathogenic bacteria...
  5. Ito H, Ishii H, Akiba M. Analysis of the complete nucleotide sequence of an Actinobacillus pleuropneumoniae streptomycin-sulfonamide resistance plasmid, pMS260. Plasmid. 2004;51:41-7 pubmed
    pMS260 is an 8.1-kb non-conjugative but mobilizable plasmid that was isolated from Actinobacillus pleuropneumoniae and encodes streptomycin (SM) and sulfonamide (SA) resistances...
  6. Archambault M, Labrie J, Rioux C, Dumas F, Thibault P, Elkins C, et al. Identification and preliminary characterization of a 75-kDa hemin- and hemoglobin-binding outer membrane protein of Actinobacillus pleuropneumoniae serotype 1. Can J Vet Res. 2003;67:271-7 pubmed
    The reference strains representing serotypes 1 to 12 of Actinobacillus pleuropneumoniae biotype 1 were examined for their ability to utilize porcine hemoglobin (Hb) or porcine hemin (Hm) as iron sources for growth...
  7. Xu Z, Zhou Y, Li L, Zhou R, Xiao S, Wan Y, et al. Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China. PLoS ONE. 2008;3:e1450 pubmed publisher
    b>Actinobacillus pleuropneumoniae is the etiologic agent of porcine contagious pleuropneumonia, a cause of considerable world wide economic losses in the swine industry. We sequenced the complete genome of A...
  8. Ganeshnarayan K, Shah S, Libera M, Santostefano A, Kaplan J. Poly-N-acetylglucosamine matrix polysaccharide impedes fluid convection and transport of the cationic surfactant cetylpyridinium chloride through bacterial biofilms. Appl Environ Microbiol. 2009;75:1308-14 pubmed publisher
    ..of the PNAG matrix in biofilms produced in vitro by the gram-negative porcine respiratory pathogen Actinobacillus pleuropneumoniae and the gram-positive device-associated pathogen Staphylococcus epidermidis...
  9. Boekema B, van Putten J, Stockhofe Zurwieden N, Smith H. Host cell contact-induced transcription of the type IV fimbria gene cluster of Actinobacillus pleuropneumoniae. Infect Immun. 2004;72:691-700 pubmed
    ..for the molecular basis of the reported variable expression of the Tfp gene cluster of the pathogen Actinobacillus pleuropneumoniae. Despite the presence of an intact Tfp gene cluster consisting of four genes, apfABCD, no Tfp were ..

More Information

Publications138 found, 100 shown here

  1. Paradis M, Vessie G, Merrill J, Dick C, Moore C, Charbonneau G, et al. Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine. Can J Vet Res. 2004;68:7-11 pubmed
    The efficacy of tilmicosin administered in the feed to control Actinobacillus pleuropneumoniae infections in pigs was evaluated through a multisite, multitrial study...
  2. Chiers K, Donné E, Van Overbeke I, Ducatelle R, Haesebrouck F. Actinobacillus pleuropneumoniae infections in closed swine herds: infection patterns and serological profiles. Vet Microbiol. 2002;85:343-52 pubmed
    Many farrow-to-finish herds are endemically infected with Actinobacillus pleuropneumoniae. In order to control the disease efficiently, a better knowledge of the ages at which pigs become infected is necessary...
  3. Shryock T, Staples J, DeRosa D. Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella multocida and Actinobacillus pleuropneumoniae associated with porcine respiratory disease. J Vet Diagn Invest. 2002;14:389-95 pubmed
    ..as a feed premix to control porcine respiratory disease associated with Pasteurella multocida and Actinobacillus pleuropneumoniae. The development of antimicrobial susceptibility testing guidelines for tilmicosin was predicated on ..
  4. Hennig I, Teutenberg Riedel B, Gerlach G. Downregulation of a protective Actinobacillus pleuropneumoniae antigen during the course of infection. Microb Pathog. 1999;26:53-63 pubmed
    The persistence of Actinobacillus pleuropneumoniae in convalescent pigs significantly contributes to the distribution of disease...
  5. Tumamao J, Bowles R, van den Bosch H, Klaasen H, Fenwick B, Blackall P. An evaluation of the role of antibodies to Actinobacillus pleuropneumoniae serovar 1 and 15 in the protection provided by sub-unit and live streptomycin-dependent pleuropneumonia vaccines. Aust Vet J. 2004;82:773-80 pubmed
    ..the Porcilis APP vaccine or a modified live vaccine based on a streptomycin-dependent (SD) strain of Actinobacillus pleuropneumoniae, and then challenged with an Australian isolate of A...
  6. Chien M, Chan Y, Chen Z, Wu C, Liao J, Chen T, et al. Actinobacillus pleuropneumoniae serotype 10 derived ApxI induces apoptosis in porcine alveolar macrophages. Vet Microbiol. 2009;135:327-33 pubmed publisher
    b>Actinobacillus pleuropneumoniae (AP) is the causative agent of swine pleuropneumonia, a fibrinous, exudative, hemorrhagic, necrotizing pleuropneumonia affecting all ages of pigs...
  7. Seah J, Frey J, Kwang J. The N-terminal domain of RTX toxin ApxI of Actinobacillus pleuropneumoniae elicits protective immunity in mice. Infect Immun. 2002;70:6464-7 pubmed
    We expressed three Actinobacillus pleuropneumoniae ApxI deletion derivatives to map the domain that could induce protective immunity...
  8. Tonpitak W, Thiede S, Oswald W, Baltes N, Gerlach G. Actinobacillus pleuropneumoniae iron transport: a set of exbBD genes is transcriptionally linked to the tbpB gene and required for utilization of transferrin-bound iron. Infect Immun. 2000;68:1164-70 pubmed
    Upon iron restriction, Actinobacillus pleuropneumoniae has been shown to express the transferrin-binding proteins TbpB and TbpA, both of which have been implied to be important virulence factors...
  9. Kristensen C, Angen Ø, Andreasen M, Takai H, Nielsen J, Jorsal S. Demonstration of airborne transmission of Actinobacillus pleuropneumoniae serotype 2 between simulated pig units located at close range. Vet Microbiol. 2004;98:243-9 pubmed
    Airborne transmission of Actinobacillus pleuropneumoniae was studied as the percentage of air needed to establish airborne transmission from an infected pig unit into a neighbouring non-infected pig unit...
  10. Huang H, Zhou R, Fan H, Dan H, Chen M, Yan L, et al. Generation of monoclonal antibodies and epitope mapping of ApxIVA of Actinobacillus pleuropneumoniae. Mol Immunol. 2006;43:2130-4 pubmed
    To study functions of ApxIV, a species-specific and in vivo inducible RTX toxin identified in Actinobacillus pleuropneumoniae recently, and to develop a diagnostic trial distinguishing the pigs infected naturally and vaccinated with ..
  11. Moser R, Reverter A, Lehnert S. Gene expression profiling of porcine peripheral blood leukocytes after infection with Actinobacillus pleuropneumoniae. Vet Immunol Immunopathol. 2008;121:260-74 pubmed
    ..profile of peripheral blood leukocytes (PBL) from extreme performing pigs after infection with Actinobacillus pleuropneumoniae was analysed using a custom complementary DNA (cDNA) microarray and quantitative reverse ..
  12. Park C, Ha Y, Kim S, Chae C, Ryu D. Construction and characterization of an Actinobacillus pleuropneumoniae serotype 2 mutant lacking the Apx toxin secretion protein genes apxIIIB and apxIIID. J Vet Med Sci. 2009;71:1317-23 pubmed
    Apx toxins have been identified as important virulence factors of Actinobacillus pleuropneumoniae, the etiologic agent of porcine pleuropneumonia. In some A...
  13. Jeannotte M, Abul Milh M, Dubreuil J, Jacques M. Binding of Actinobacillus pleuropneumoniae to phosphatidylethanolamine. Infect Immun. 2003;71:4657-63 pubmed
    The gram-negative bacterium Actinobacillus pleuropneumoniae is the causative agent of porcine fibrinohemorrhagic necrotizing pleuropneumonia, a disease that causes important economic losses to the swine industry worldwide...
  14. Moser R, Reverter A, Kerr C, Beh K, Lehnert S. A mixed-model approach for the analysis of cDNA microarray gene expression data from extreme-performing pigs after infection with Actinobacillus pleuropneumoniae. J Anim Sci. 2004;82:1261-71 pubmed
    ..blood leukocytes of two pigs showing extreme performance in their response to infection with Actinobacillus pleuropneumoniae. Principal components analyses were used to identify the two most extreme-performing pigs after ..
  15. Fu S, Ou J, Zhang M, Xu J, Liu H, Liu J, et al. The live attenuated Actinobacillus pleuropneumoniae triple-deletion mutant ?apxIC ?apxIIC ?apxIV-ORF1 strain, SLW05, Immunizes pigs against lethal challenge with Haemophilus parasuis. Clin Vaccine Immunol. 2013;20:134-9 pubmed publisher
    Haemophilus parasuis and Actinobacillus pleuropneumoniae both belong to the family Pasteurellaceae and are major respiratory pathogens that cause large economic losses in the pig industry worldwide...
  16. Gram T, Ahrens P, Nielsen J. Evaluation of a PCR for detection of Actinobacillus pleuropneumoniae in mixed bacterial cultures from tonsils. Vet Microbiol. 1996;51:95-104 pubmed
    A PCR for the detection of Actinobacillus pleuropneumoniae was evaluated. All of 102 field, isolates of A, pleuropneumoniae reacted in the PCR by amplification of a 985 bp product...
  17. Cho W, Choi C, Chae C. In situ hybridization for the detection of the apxIV gene in the lungs of pigs experimentally infected with twelve Actinobacillus pleuropneumoniae serotypes. Vet Res. 2002;33:653-60 pubmed
    ..pleuropneumoniae when only formalin-fixed tissues are submitted for diagnosis...
  18. O Neilla C, Jones S, Bosse J, Watson C, Williamson S, Rycroft A, et al. Population-based analysis of Actinobacillus pleuropneumoniae ApxIVA for use as a DIVA antigen. Vaccine. 2010;28:4871-4874 pubmed publisher
    APXIVA is an RTX toxin of Actinobacillus pleuropneumoniae that is a candidate antigen to differentiate infected from vaccinated animals (DIVA)...
  19. Jacques M. Surface polysaccharides and iron-uptake systems of Actinobacillus pleuropneumoniae. Can J Vet Res. 2004;68:81-5 pubmed
    b>Actinobacillus pleuropneumoniae is the etiologic agent of porcine pleuropneumonia. Infection by A...
  20. Wang C, Wang Y, Shao M, Si W, Liu H, Chang Y, et al. Positive role for rApxIVN in the immune protection of pigs against infection by Actinobacillus pleuropneumoniae. Vaccine. 2009;27:5816-21 pubmed publisher
    The role of in vivo-induced ApxIV toxin of Actinobacillus pleuropneumoniae in protective immunity was evaluated in pigs by administering it alone or added to a multicomponent recombinant subunit vaccine composed of recombinant ApxI, ..
  21. Huang H, Potter A, Campos M, Leighton F, Willson P, Haines D, et al. Pathogenesis of porcine Actinobacillus pleuropneumonia, part II: roles of proinflammatory cytokines. Can J Vet Res. 1999;63:69-78 pubmed
    The in vitro production of proinflammatory cytokines after stimulation with Actinobacillus pleuropneumoniae and the relation of these cytokines in vivo with the disease caused by A. pleuropneumoniae were investigated...
  22. Jessing S, Angen Ø, Inzana T. Evaluation of a multiplex PCR test for simultaneous identification and serotyping of Actinobacillus pleuropneumoniae serotypes 2, 5, and 6. J Clin Microbiol. 2003;41:4095-100 pubmed
    ..used to develop a multiplex PCR test for the simultaneous species identification and serotyping of Actinobacillus pleuropneumoniae serotypes 2, 5, and 6...
  23. Shin S, Bae J, Cho Y, Lee D, Kim D, Yang M, et al. Induction of antigen-specific immune responses by oral vaccination with Saccharomyces cerevisiae expressing Actinobacillus pleuropneumoniae ApxIIA. FEMS Immunol Med Microbiol. 2005;43:155-64 pubmed
    An effective way of inducing both mucosal and systemic immune responses to protect against Actinobacillus pleuropneumoniae serotype 2 Korean isolate was examined in mice by oral immunization using Saccharomyces cerevisiae expressing the ..
  24. Daniłowicz E, Martinez Arias R, Dolf G, Singh M, Probst I, Tummler B, et al. Characterization of the porcine transferrin gene (TF) and its association with disease severity following an experimental Actinobacillus pleuropneumoniae infection. Anim Genet. 2010;41:424-7 pubmed publisher
    ..association analyses using six selected TF markers and 116 pigs experimentally infected with Actinobacillus pleuropneumoniae serotype 7. The analysis showed breed-specific TF allele frequencies...
  25. Cho W, Chae C. Expression of the apxIV gene in pigs naturally infected with Actinobacillus pleuropneumoniae. J Comp Pathol. 2001;125:34-40 pubmed
    ..in formalin-fixed, paraffin wax-embedded samples of lung tissue from 10 pigs naturally infected with Actinobacillus pleuropneumoniae. A 442 base pair DNA probe of the apxIV gene from A...
  26. Myers M, Baarsch M, Murtaugh M. Effects of pentoxifylline on inflammatory cytokine expression and acute pleuropneumonia in swine. Immunobiology. 2002;205:17-34 pubmed
    ..These results suggest that pentoxifylline is an effective pharmacological tool for the dissection of cytokine regulation in vitro, but inhibitory concentrations may not be achievable for in vivo pharmacological use in swine...
  27. MacLean L, Perry M, Vinogradov E. Characterization of the antigenic lipopolysaccharide O chain and the capsular polysaccharide produced by Actinobacillus pleuropneumoniae serotype 13. Infect Immun. 2004;72:5925-30 pubmed
    Serotyping of Actinobacillus pleuropneumoniae, the etiologic agent of porcine pleuropneumonia, is important for epidemiological studies and for the development of homologous vaccine cell preparations...
  28. Gerlach G, Klashinsky S, Anderson C, Potter A, Willson P. Characterization of two genes encoding distinct transferrin-binding proteins in different Actinobacillus pleuropneumoniae isolates. Infect Immun. 1992;60:3253-61 pubmed
    The gene encoding the Actinobacillus pleuropneumoniae serotype 1 transferrin-binding protein (tfbA) was cloned, and the carboxy-terminal 70% of the protein was expressed as an aggregate protein in Escherichia coli...
  29. Hensel A, Huter V, Katinger A, Raza P, Strnistschie C, Roesler U, et al. Intramuscular immunization with genetically inactivated (ghosts) Actinobacillus pleuropneumoniae serotype 9 protects pigs against homologous aerosol challenge and prevents carrier state. Vaccine. 2000;18:2945-55 pubmed
    ..Currently available porcine Actinobacillus pleuropneumoniae vaccines afford only minimal protection by decreasing mortality but not morbidity...
  30. Fuller T, Martin S, Teel J, Alaniz G, Kennedy M, Lowery D. Identification of Actinobacillus pleuropneumoniae virulence genes using signature-tagged mutagenesis in a swine infection model. Microb Pathog. 2000;29:39-51 pubmed
    b>Actinobacillus pleuropneumoniae is a significant respiratory pathogen of swine causing a severe and often fatal fibrinous hemorrhagic bronchopneumonia with significant economic losses resulting from chronic as well as acute infections...
  31. Johansson E, Fossum C, Fuxler L, Wallgren P. Effects of an experimental infection with Actinobacillus pleuropneumoniae on the interferon-alpha and interleukin-6 producing capacity of porcine peripheral blood mononuclear cells stimulated with bacteria, virus or plasmid DNA. Vet Microbiol. 2001;79:171-82 pubmed
    ..by porcine cells was studied in specific pathogen-free (SPF) pigs, infected intranasally with Actinobacillus pleuropneumoniae serotype 2...
  32. Myers M, Farrell D, Snider T, Post L. Inflammatory cytokines, pleuropneumonia infection and the effect of dexamethasone. Pathobiology. 2004;71:35-42 pubmed
    b>Actinobacillus pleuropneumoniae causes an often fatal infection of swine due to pleuropneumonia. To determine if inflammatory cytokines are associated with A...
  33. Cirera S, Nygård A, Jensen H, Skovgaard K, Boye M, Fredholm M. Molecular characterization of the porcine surfactant, pulmonary-associated protein C gene. Genomics. 2006;88:659-68 pubmed
    ..in lung by real-time RT-PCR and they were significantly down-regulated in necrotic lungs of pigs infected with Actinobacillus pleuropneumoniae. Additionally, the protein levels were also decreased or absent in the necrotic tissue.
  34. Boekema B, Kamp E, Smits M, Smith H, Stockhofe Zurwieden N. Both ApxI and ApxII of Actinobacillus pleuropneumoniae serotype 1 are necessary for full virulence. Vet Microbiol. 2004;100:17-23 pubmed
    ..The results indicate that both ApxI and ApxII of A. pleuropneumoniae serotype 1 are necessary for full virulence. ..
  35. Bernardy J, Nechvatalova K, Krejci J, Kudlackova H, Brazdova I, Kucerova Z, et al. Comparison of different doses of antigen for intradermal administration in pigs: the Actinobacillus pleuropneumoniae model. Vaccine. 2008;26:6368-72 pubmed publisher
    The intensity of antibody responses and level of protection against challenge infection induced by Actinobacillus pleuropneumoniae (APP) were compared in piglets vaccinated intramuscularly with different vaccination doses of a subunit ..
  36. Xu Z, Chen X, Li L, Li T, Wang S, Chen H, et al. Comparative genomic characterization of Actinobacillus pleuropneumoniae. J Bacteriol. 2010;192:5625-36 pubmed publisher
    The Gram-negative bacterium Actinobacillus pleuropneumoniae is the etiologic agent of porcine contagious pleuropneumoniae, a lethal respiratory infectious disease causing great economic losses in the swine industry worldwide...
  37. Tobias T, Bouma A, Daemen A, Wagenaar J, Stegeman A, Klinkenberg D. Association between transmission rate and disease severity for Actinobacillus pleuropneumoniae infection in pigs. Vet Res. 2013;44:2 pubmed publisher
    ..Here we investigated the role of disease severity on infectivity and transmission of Actinobacillus pleuropneumoniae, a bacterium causing respiratory problems in pig farms...
  38. Provost M, Harel J, Labrie J, Sirois M, Jacques M. Identification, cloning and characterization of rfaE of Actinobacillus pleuropneumoniae serotype 1, a gene involved in lipopolysaccharide inner-core biosynthesis. FEMS Microbiol Lett. 2003;223:7-14 pubmed
    b>Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia and its lipopolysaccharides (LPS) have been identified as important adhesins involved in adherence to host cells...
  39. Baltes N, Hennig Pauka I, Jacobsen I, Gruber A, Gerlach G. Identification of dimethyl sulfoxide reductase in Actinobacillus pleuropneumoniae and its role in infection. Infect Immun. 2003;71:6784-92 pubmed
    b>Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, is capable of persisting in oxygen-deprived surroundings, namely, tonsils and sequestered necrotic lung tissue...
  40. Baltes N, Buettner F, Gerlach G. Selective capture of transcribed sequences (SCOTS) of Actinobacillus pleuropneumoniae in the chronic stage of disease reveals an HlyX-regulated autotransporter protein. Vet Microbiol. 2007;123:110-21 pubmed
    b>Actinobacillus pleuropneumoniae, an important respiratory pathogen in swine, is able to persist in host tissues for extended periods of time...
  41. Foote S, Bosse J, Bouevitch A, Langford P, Young N, Nash J. The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b). J Bacteriol. 2008;190:1495-6 pubmed
    There are 16 capsule-based serotypes of Actinobacillus pleuropneumoniae, all of which are capable of causing disease in pigs. Here we report the finished and annotated genome sequence of the reference serotype 5b strain L20...
  42. MacInnes J, Gottschalk M, Lone A, Metcalf D, Ojha S, Rosendal T, et al. Prevalence of Actinobacillus pleuropneumoniae, Actinobacillus suis, Haemophilus parasuis, Pasteurella multocida, and Streptococcus suis in representative Ontario swine herds. Can J Vet Res. 2008;72:242-8 pubmed
    ..Seventy-eight percent of the herds were diagnosed positive for Actinobacillus pleuropneumoniae by apxIV PCR...
  43. Hoeltig D, Hennig Pauka I, Thies K, Rehm T, Beyerbach M, Strutzberg Minder K, et al. A novel Respiratory Health Score (RHS) supports a role of acute lung damage and pig breed in the course of an Actinobacillus pleuropneumoniae infection. BMC Vet Res. 2009;5:14 pubmed publisher
    ..pleuropneumoniae...
  44. Chen Z, Chien M, Chang N, Chen T, Wu C, Huang C, et al. Mechanisms underlying Actinobacillus pleuropneumoniae exotoxin ApxI induced expression of IL-1?, IL-8 and TNF-? in porcine alveolar macrophages. Vet Res. 2011;42:25 pubmed publisher
    b>Actinobacillus pleuropneumoniae (A. pleuropneumoniae) causes fibrino-hemorrhagic necrotizing pleuropneumonia in pigs. Production of proinflammatory mediators in the lungs is an important feature of A. pleuropneumoniae infection...
  45. Fossum C, Wattrang E, Fuxler L, Jensen K, Wallgren P. Evaluation of various cytokines (IL-6, IFN-alpha, IFN-gamma, TNF-alpha) as markers for acute bacterial infection in swine--a possible role for serum interleukin-6. Vet Immunol Immunopathol. 1998;64:161-72 pubmed
    ..controls while the other 56 pigs were infected intranasally with approximately 7 x 10(8) CFU of Actinobacillus pleuropneumoniae serotype 2 (strain 700/89) in 1 ml saline...
  46. Buettner F, Bendallah I, Bosse J, Dreckmann K, Nash J, Langford P, et al. Analysis of the Actinobacillus pleuropneumoniae ArcA regulon identifies fumarate reductase as a determinant of virulence. Infect Immun. 2008;76:2284-95 pubmed publisher
    The ability of the bacterial pathogen Actinobacillus pleuropneumoniae to grow anaerobically allows the bacterium to persist in the lung...
  47. Sjolund M, Zoric M, Persson M, Karlsson G, Wallgren P. Disease patterns and immune responses in the offspring to sows with high or low antibody levels to Actinobacillus pleuropneumoniae serotype 2. Res Vet Sci. 2011;91:25-31 pubmed publisher
    The serum antibody responses to Actinobacillus pleuropneumoniae and the secondary invader Pasteurella multocida were monitored from birth until slaughter in the offspring to sows with high or low levels of serum antibodies to A...
  48. Buettner F, Maas A, Gerlach G. An Actinobacillus pleuropneumoniae arcA deletion mutant is attenuated and deficient in biofilm formation. Vet Microbiol. 2008;127:106-15 pubmed
    b>Actinobacillus pleuropneumoniae is a facultative anaerobic pathogen of the porcine respiratory tract requiring anaerobic metabolic activity for persistence on lung epithelium...
  49. Kang M, Zhou R, Liu L, Langford P, Chen H. Analysis of an Actinobacillus pleuropneumoniae multi-resistance plasmid, pHB0503. Plasmid. 2009;61:135-9 pubmed publisher
    A plasmid containing multidrug resistance genes has been discovered from a clinical Actinobacillus pleuropneumoniae strain isolated in China...
  50. van Overbeke I, Chiers K, Ducatelle R, Haesebrouck F. Effect of endobronchial challenge with Actinobacillus pleuropneumoniae serotype 9 of pigs vaccinated with a vaccine containing Apx toxins and transferrin-binding proteins. J Vet Med B Infect Dis Vet Public Health. 2001;48:15-20 pubmed
    The efficacy of a subunit vaccine containing the Apx toxins of Actinobacillus pleuropneumoniae and transferrin-binding proteins was determined. Ten pigs were vaccinated twice with the vaccine...
  51. Tonpitak W, Baltes N, Hennig Pauka I, Gerlach G. Construction of an Actinobacillus pleuropneumoniae serotype 2 prototype live negative-marker vaccine. Infect Immun. 2002;70:7120-5 pubmed
    Deletions were introduced into the ureC and apxIIA genes of an Actinobacillus pleuropneumoniae serotype 2 strain by homologous recombination and counterselection...
  52. Hultén C, Johansson E, Fossum C, Wallgren P. Interleukin 6, serum amyloid A and haptoglobin as markers of treatment efficacy in pigs experimentally infected with Actinobacillus pleuropneumoniae. Vet Microbiol. 2003;95:75-89 pubmed
    ..this possibility, the acute phase response (IL-6, serum amyloid A (SAA), and haptoglobin) elicited by Actinobacillus pleuropneumoniae and its reduction on treatment with various antibiotics was studied in serum from specific pathogen ..
  53. Cho W, Chae C. In vitro effects of Actinobacillus pleuropneumoniae on inducible nitric oxide synthase and cyclooxygenase-2 in porcine alveolar macrophages. Am J Vet Res. 2003;64:1514-8 pubmed
    ..oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activity in alveolar macrophages in response to Actinobacillus pleuropneumoniae (APP) by determining nitric oxide (NO) and prostaglandin E2 (PGE2) concentrations...
  54. Seo K, Kim D, Kim A, Yoo H, Lee K, Jang Y. Characterization of antigenic determinants in ApxIIA exotoxin capable of inducing protective immunity to Actinobacillus pleuropneumoniae challenge. Immunol Invest. 2011;40:465-80 pubmed publisher
    b>Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia...
  55. Li L, Xu Z, Zhou Y, Sun L, Liu Z, Chen H, et al. Global effects of catecholamines on Actinobacillus pleuropneumoniae gene expression. PLoS ONE. 2012;7:e31121 pubmed publisher
    ..b>Actinobacillus pleuropneumoniae is an important porcine respiratory pathogen causing great economic losses in the pig industry ..
  56. Mikael L, Pawelek P, Labrie J, Sirois M, Coulton J, Jacques M. Molecular cloning and characterization of the ferric hydroxamate uptake (fhu) operon in Actinobacillus pleuropneumoniae. Microbiology. 2002;148:2869-82 pubmed
    The bacterium Actinobacillus pleuropneumoniae, a swine pathogen, utilizes ferrichrome as an iron source. This study details the molecular cloning and sequencing of the genes involved in the uptake of this hydroxamate siderophore...
  57. Nielsen K, Boye M. Real-time quantitative reverse transcription-PCR analysis of expression stability of Actinobacillus pleuropneumoniae housekeeping genes during in vitro growth under iron-depleted conditions. Appl Environ Microbiol. 2005;71:2949-54 pubmed
    ..a sensitive and reproducible method for the study of gene expression in the porcine lung pathogen Actinobacillus pleuropneumoniae by real-time quantitative reverse transcription (RT)-PCR and to evaluate a number of suitable ..
  58. Ramjeet M, Cox A, Hancock M, Mourez M, Labrie J, Gottschalk M, et al. Mutation in the LPS outer core biosynthesis gene, galU, affects LPS interaction with the RTX toxins ApxI and ApxII and cytolytic activity of Actinobacillus pleuropneumoniae serotype 1. Mol Microbiol. 2008;70:221-35 pubmed publisher
    Lipopolysaccharides (LPS) and Apx toxins are major virulence factors of Actinobacillus pleuropneumoniae, a pathogen of the respiratory tract of pigs...
  59. Tegetmeyer H, Fricke K, Baltes N. An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Vet Microbiol. 2009;137:392-6 pubmed publisher
    AasP, an autotransporter serine protease of Actinobacillus pleuropneumoniae, has been shown to be expressed in necrotic porcine lung tissue. Based on the hypothesis that AasP might play an important role in A...
  60. Stevenson A, MacDonald J, Roberts M. Cloning and characterisation of type 4 fimbrial genes from Actinobacillus pleuropneumoniae. Vet Microbiol. 2003;92:121-34 pubmed
    b>Actinobacillus pleuropneumoniae is the cause of porcine pleuropneumoniae. Little is known about the mechanisms by which A. pleuropneumoniae colonises the respiratory tract...
  61. Vigre H, Dohoo I, Stryhn H, Busch M. Intra-unit correlations in seroconversion to Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae at different levels in Danish multi-site pig production facilities. Prev Vet Med. 2004;63:9-28 pubmed
    ..between pigs produced in Danish multi-site pig production facilities regarding seroconversion to Actinobacillus pleuropneumoniae serotype 2 (Ap2) and Mycoplasma hyopneumoniae (Mh)...
  62. Wagner T, Mulks M. Identification of the Actinobacillus pleuropneumoniae leucine-responsive regulatory protein and its involvement in the regulation of in vivo-induced genes. Infect Immun. 2007;75:91-103 pubmed
    b>Actinobacillus pleuropneumoniae is a gram-negative bacterial pathogen that causes a severe hemorrhagic pneumonia in swine...
  63. Bei W, He Q, Zhou R, Yan L, Huang H, Chen H. Evaluation of immunogenicity and protective efficacy of Actinobacillus pleuropneumoniae HB04C(-) mutant lacking a drug resistance marker in the pigs. Vet Microbiol. 2007;125:120-7 pubmed
    Previously, we reported the construction and characterization of a genetically defined Actinobacillus pleuropneumoniae (A. pleuropneumoniae) apxIIC gene mutant, HB04C(-), which conferred protection to mice against infection with A...
  64. Godara G, Smith C, Bosse J, Zeidel M, Mathai J. Functional characterization of Actinobacillus pleuropneumoniae urea transport protein, ApUT. Am J Physiol Regul Integr Comp Physiol. 2009;296:R1268-73 pubmed publisher
    ..We have characterized the urea transport channel protein ApUT from Actinobacillus pleuropneumoniae. Kinetic analysis of bacterial inside-out membranes enriched in ApUT showed approximately 28-fold ..
  65. Shao M, Wang Y, Wang C, Guo Y, Peng Y, Liu J, et al. Evaluation of multicomponent recombinant vaccines against Actinobacillus pleuropneumoniae in mice. Acta Vet Scand. 2010;52:52 pubmed publisher
    Porcine contagious pleuropneumonia (PCP) is a highly contagious disease that is caused by Actinobacillus pleuropneumoniae (APP) and characterized by severe fibrinous necrotizing hemorrhagic pleuropneumonia, which is a severe threat to ..
  66. Tumamao J, Bowles R, van den Bosch H, Klaasen H, Fenwick B, Storie G, et al. Comparison of the efficacy of a subunit and a live streptomycin-dependent porcine pleuropneumonia vaccine. Aust Vet J. 2004;82:370-4 pubmed
    To evaluate the efficacy of two new-generation porcine pleuropneumonia vaccines when challenged with Australian isolates of Actinobacillus pleuropneumoniae of serovars 1 and 15.
  67. Kaplan J, Mulks M. Biofilm formation is prevalent among field isolates of Actinobacillus pleuropneumoniae. Vet Microbiol. 2005;108:89-94 pubmed
    A total of 77 field isolates and 15 reference strains of the porcine respiratory pathogen Actinobacillus pleuropneumoniae were tested for their ability to form biofilms in a polystyrene microtiter plate assay...
  68. Cho W, Chae C. Genotypic prevalence of apx1V in Actinobacillus pleuropneumoniae field isolates. J Vet Diagn Invest. 2001;13:175-7 pubmed
    A total of 90 Actinobacillus pleuropneumoniae field strains from pigs were serotyped by slide agglutination and analyzed for the presence of the apxIV gene by polymerase chain reaction...
  69. Baltes N, Kyaw S, Hennig Pauka I, Gerlach G. Lack of influence of the anaerobic [NiFe] hydrogenase and L-1,2 propanediol oxidoreductase on the outcome of Actinobacillus pleuropneumoniae serotype 7 infection. Vet Microbiol. 2004;102:67-72 pubmed
    ..Deletion of the hybB or fucO genes appeared to have no significant effect on A. pleuropneumoniae virulence...
  70. Cho W, Chae C. Expression of nitric oxide synthase 2 and cyclooxygenase-2 in swine experimentally infected with Actinobacillus pleuropneumoniae. Vet Pathol. 2004;41:666-72 pubmed
    The expression of inflammatory mediators was examined in pigs experimentally infected with Actinobacillus pleuropneumoniae. The activity of nitric oxide synthase 2 (NOS2) and cyclooxygenase-2 (COX-2) was determined by measuring nitric ..
  71. Koyama T, To H, Nagai S. Isolation of Actinobacillus pleuropneumoniae serovar 15-like strain from a field case of porcine pleuropneumonia in Japan. J Vet Med Sci. 2007;69:961-4 pubmed
    An Actinobacillus pleuropneumoniae strain isolated from a field case of porcine pleuropneumonia in Japan, was closely related to a reference strain of serovar 15, which is a newly proposed serovar according to an analysis of field ..
  72. Rehm T, Benga L, Danilowicz E, Drungowski M, Hoeltig D, Kahlisch D, et al. [Functional genome analysis investigating resistance to respiratory tract disease in a porcine Actinobacillus pleuropneumoniae infection model]. Dtsch Tierarztl Wochenschr. 2008;115:260-4 pubmed
    ..IRAS started work in the fall of 2005 and--using the experimental infection of pigs with Actinobacillus pleuropneumoniae as model pathogen--aims at i) characterizing the course of infection by clinical as well as advanced ..
  73. Marois C, Gottschalk M, Morvan H, Fablet C, Madec F, Kobisch M. Experimental infection of SPF pigs with Actinobacillus pleuropneumoniae serotype 9 alone or in association with Mycoplasma hyopneumoniae. Vet Microbiol. 2009;135:283-91 pubmed publisher
    The purpose of this study was to compare in SPF pigs, the pathogenicity of an Actinobacillus pleuropneumoniae serotype 9 strain 21 (isolated from the palatine tonsils of a healthy gilt on a French nucleus pig farm, with no clinical signs ..
  74. Balaji R, Wright K, Turner J, Hill C, Dritz S, Fenwick B, et al. Circulating cortisol, tumor necrosis factor-alpha interleukin-1beta, and interferon-gamma in pigs infected with Actinobacillus pleuropneumoniae. J Anim Sci. 2002;80:202-7 pubmed
    ..systemic cytokine concentrations in an acute model of pneumonia in pigs challenged intranasally with Actinobacillus pleuropneumoniae. Feed intake and serum cortisol were measured as overt clinical and systemic markers of disease onset,..
  75. Yoshimura H, Takagi M, Ishimura M, Endoh Y. Comparative in vitro activity of 16 antimicrobial agents against Actinobacillus pleuropneumoniae. Vet Res Commun. 2002;26:11-9 pubmed
    Sixteen antimicrobial agents were tested for their activity against 68 isolates of Actinobacillus pleuropneumoniae by determining the minimum inhibitory concentrations (MICs)...
  76. Enríquez Verdugo I, Guerrero A, Serrano J, Godínez D, Rosales J, Tenorio V, et al. Adherence of Actinobacillus pleuropneumoniae to swine-lung collagen. Microbiology. 2004;150:2391-400 pubmed
    b>Actinobacillus pleuropneumoniae serotype 1 adhered to immobilized swine-lung collagen. Bacteria bound to collagen type I, III, IV and V. At 5 min incubation, 30 % of bacteria adhered to collagen, reaching saturation in around 90 min...
  77. Zhou L, Jones S, Angen Ø, Bosse J, Nash J, Frey J, et al. Multiplex PCR that can distinguish between immunologically cross- reactive serovar 3, 6, and 8 Actinobacillus pleuropneumoniae strains. J Clin Microbiol. 2008;46:800-3 pubmed
    ..multiplex PCR, based on capsular loci and the species specific apxIV gene, that unequivocally differentiates serovar 3, 6, and 8 Actinobacillus pleuropneumoniae strains that are cross-reactive in conventional immunological tests.
  78. Jessing S, Ahrens P, Inzana T, Angen Ø. The genetic organisation of the capsule biosynthesis region of Actinobacillus pleuropneumoniae serotypes 1, 6, 7, and 12. Vet Microbiol. 2008;129:350-9 pubmed publisher
    ..the organisation of the genes (cps) involved in biosynthesis the capsular polysaccharide (CPS) of Actinobacillus pleuropneumoniae serotypes 6, 7, and 12 and to compare these to the corresponding genes previously described in other ..
  79. Yang W, Pin C, Haibing G, Yang C, Hui L, Qigai H. Loop-mediated isothermal amplification targeting the apxIVA gene for detection of Actinobacillus pleuropneumoniae. FEMS Microbiol Lett. 2009;300:83-9 pubmed publisher
    ..We developed a diagnostic method based on LAMP for detection of Actinobacillus pleuropneumoniae. Using six specific primers targeting the apxIVA gene, the LAMP assay rapidly amplified the target ..
  80. Li G, Xie F, Zhang Y, Wang C. Draft genome sequence of Actinobacillus pleuropneumoniae serotype 7 strain S-8. J Bacteriol. 2012;194:6606-7 pubmed publisher
    The Gram-negative bacterium Actinobacillus pleuropneumoniae is the etiological agent of porcine pleuropneumonia, a respiratory disease that leads to severe economic losses in the swine industry...
  81. Fittipaldi N, Broes A, Harel J, Kobisch M, Gottschalk M. Evaluation and field validation of PCR tests for detection of Actinobacillus pleuropneumoniae in subclinically infected pigs. J Clin Microbiol. 2003;41:5085-93 pubmed
    Eight PCR tests were evaluated for their abilities to detect Actinobacillus pleuropneumoniae in swine tonsils. At first they were compared regarding their specificities by using A...
  82. Srikumar R, Mikael L, Pawelek P, Khamessan A, Gibbs B, Jacques M, et al. Molecular cloning of haemoglobin-binding protein HgbA in the outer membrane of Actinobacillus pleuropneumoniae. Microbiology. 2004;150:1723-34 pubmed
    From the porcine pathogen Actinobacillus pleuropneumoniae cultivated in iron-deficient or haem-deficient media, haemoglobin (Hb)-agarose affinity purification was exploited to isolate an outer-membrane protein of approximately 105 kDa, ..
  83. Baltes N, Gerlach G. Identification of genes transcribed by Actinobacillus pleuropneumoniae in necrotic porcine lung tissue by using selective capture of transcribed sequences. Infect Immun. 2004;72:6711-6 pubmed
    Genes expressed by Actinobacillus pleuropneumoniae in necrotic porcine lung tissue were identified by selective capture of transcribed sequences analysis...
  84. Gutiérrez Martín C, del Blanco N, Blanco M, Navas J, Rodríguez Ferri E. Changes in antimicrobial susceptibility of Actinobacillus pleuropneumoniae isolated from pigs in Spain during the last decade. Vet Microbiol. 2006;115:218-22 pubmed
    A total of 229 Spanish Actinobacillus pleuropneumoniae isolates recovered from diseased pigs with pleuropneumonia from 1997 to 2004 was tested for their susceptibility to 11 antimicrobials in a broth microdilution method...
  85. Maas A, Jacobsen I, Meens J, Gerlach G. Use of an Actinobacillus pleuropneumoniae multiple mutant as a vaccine that allows differentiation of vaccinated and infected animals. Infect Immun. 2006;74:4124-32 pubmed
    Vaccination against Actinobacillus pleuropneumoniae is hampered by the lack of vaccines inducing reliable cross-serotype protection...
  86. Gioia J, Qin X, Jiang H, Clinkenbeard K, Lo R, Liu Y, et al. The genome sequence of Mannheimia haemolytica A1: insights into virulence, natural competence, and Pasteurellaceae phylogeny. J Bacteriol. 2006;188:7257-66 pubmed
    ..haemolytica, Actinobacillus pleuropneumoniae, and Haemophilus ducreyi form a lineage distinct from other Pasteurellaceae...
  87. Mortensen S, Skovgaard K, Hedegaard J, Bendixen C, Heegaard P. Transcriptional profiling at different sites in lungs of pigs during acute bacterial respiratory infection. Innate Immun. 2011;17:41-53 pubmed publisher
    ..in different locations of lungs from pigs experimentally infected with the respiratory pathogen Actinobacillus pleuropneumoniae serotype 5B, using porcine cDNA microarrays...
  88. Podolska A, Anthon C, Bak M, Tommerup N, Skovgaard K, Heegaard P, et al. Profiling microRNAs in lung tissue from pigs infected with Actinobacillus pleuropneumoniae. BMC Genomics. 2012;13:459 pubmed publisher
    ..b>Actinobacillus pleuropneumoniae (APP) causes serious lung infections in pigs...
  89. Gonzalez G, Yu R, Rosteck P, Schryvers A. Sequence, genetic analysis, and expression of Actinobacillus pleuropneumoniae transferrin receptor genes. Microbiology. 1995;141 ( Pt 10):2405-16 pubmed
    ..and tbpB genes encoding the transferrin receptor proteins Tbp1 and Tbp2 from a serotype 7 strain of Actinobacillus pleuropneumoniae were cloned, sequenced, and expressed in Escherichia coli...
  90. Green J, Baldwin M. HlyX, the FNR homologue of Actinobacillus pleuropneumoniae, is a [4Fe-4S]-containing oxygen-responsive transcription regulator that anaerobically activates FNR-dependent class I promoters via an enhanced AR1 contact. Mol Microbiol. 1997;24:593-605 pubmed
    The hlyX gene of the pig pathogen Actinobacillus pleuropneumoniae encodes HlyX, a homologue of FNR, the anaerobic transcription regulator of Escherichia coli. The hlyX gone complements the anaerobic respiratory deficiencies of E...
  91. Maes D, Chiers K, Haesebrouck F, Laevens H, Verdonck M, de Kruif A. Herd factors associated with the seroprevalences of Actinobacillus pleuropneumoniae serovars 2, 3 and 9 in slaughter pigs from farrow-to-finish pig herds. Vet Res. 2001;32:409-19 pubmed
    ..descriptive epidemiological characteristics of infections with three different serovars of Actinobacillus pleuropneumoniae, and to identify risk factors for the within-herd seroprevalences of these serovars...
  92. Silin D, Lyubomska V. Overcoming immune tolerance during oral vaccination against Actinobacillus pleuropneumoniae. J Vet Med B Infect Dis Vet Public Health. 2002;49:169-75 pubmed
    In the preliminary study mice were vaccinated orally with Actinobacillus pleuropneumoniae microsphere oral vaccine...