chlamydophila pneumoniae

Summary

Summary: A species of CHLAMYDOPHILA that causes acute respiratory infection, especially atypical pneumonia, in humans, horses, and koalas.

Top Publications

  1. Kim T, Moon K, Lee K, Park C, Bae Y, Moon H, et al. Chlamydophila pneumoniae triggers release of CCL20 and vascular endothelial growth factor from human bronchial epithelial cells through enhanced intracellular oxidative stress and MAPK activation. J Clin Immunol. 2009;29:629-36 pubmed publisher
    b>Chlamydophila pneumoniae may contribute to the pathogenesis of asthmatic airway inflammation through chemical mediators secreted by C. pneumoniae-infected bronchial epithelial cells (BECs)...
  2. Lin T, Chen C, Wu H, Wang C, Chen Y, Eng H. The association of C (-260)-->T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients. Am J Clin Pathol. 2008;130:595-601 pubmed publisher
    ..3% vs 38.6%; P < .001). Our findings suggest that persistent C pneumoniae infection is independently associated with stroke in CC genotypes and the lowering of cHsp60 antibody levels in TT genotypes...
  3. Bandaru V, Boddu D, Laxmi V, Neeraja M, Kaul S. Seroprevalence of Chlamydia pneumoniae antibodies in stroke in young. Can J Neurol Sci. 2009;36:725-30 pubmed
    ..03). After adjustment of all risk factors C. pneumoniae IgG seropositivity showed odds ratio of 2.6; 95% Confidence Interval 1.2-5.6. C. pneumoniae IgG antibodies were found to be associated with ischemic stroke in young. ..
  4. Deniset J, Cheung P, Dibrov E, Lee K, Steigerwald S, Pierce G. Chlamydophila pneumoniae infection leads to smooth muscle cell proliferation and thickening in the coronary artery without contributions from a host immune response. Am J Pathol. 2010;176:1028-37 pubmed publisher
    ..These results demonstrate that C. pneumoniae infection can stimulate arterial thickening in a complex vessel environment without the presence of a host immune response and further supports the involvement of HSP60 in this action. ..
  5. Specjalski K, Jassem E. Chlamydophila pneumoniae, Mycoplasma pneumoniae infections, and asthma control. Allergy Asthma Proc. 2011;32:9-17 pubmed publisher
    ..The aim of this study was to evaluate the impact of Chlamydophila pneumoniae and Mycoplasma pneumoniae infections on the control and severity of asthma...
  6. Jha H, Srivastava P, Divya A, Prasad J, Mittal A. Prevalence of Chlamydophila pneumoniae is higher in aorta and coronary artery than in carotid artery of coronary artery disease patients. APMIS. 2009;117:905-11 pubmed publisher
    ..Data obtained from several seroepidemiological studies have suggested that infection with Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus and herpes simplex virus-1 can initiate or maintain the ..
  7. Di Pietro M, Schiavoni G, Sessa V, Pallotta F, Costanzo G, Sessa R. Chlamydia pneumoniae and osteoporosis-associated bone loss: a new risk factor?. Osteoporos Int. 2013;24:1677-82 pubmed publisher
    ..pneumoniae DNA, both in bone tissue and PBMCs, and the increase in sRANKL/OPG ratio as well as in IL-1? and IL-6 levels observed in osteoporotic patients suggests C. pneumoniae infection as a new risk factor for osteoporosis. ..
  8. Tang Y, Sriram S, Li H, Yao S, Meng S, Mitchell W, et al. Qualitative and quantitative detection of Chlamydophila pneumoniae DNA in cerebrospinal fluid from multiple sclerosis patients and controls. PLoS ONE. 2009;4:e5200 pubmed publisher
    A standardized molecular test for the detection of Chlamydophila pneumoniae DNA in cerebrospinal fluid (CSF) would assist the further assessment of the association of C. pneumoniae with multiple sclerosis (MS)...
  9. Hvidsten D, Halvorsen D, Berdal B, Gutteberg T. Chlamydophila pneumoniae diagnostics: importance of methodology in relation to timing of sampling. Clin Microbiol Infect. 2009;15:42-9 pubmed publisher
    ..compared to single-serum IgM antibody measurement and IgG antibody seroconversion during an outbreak of Chlamydophila pneumoniae in a military community...

More Information

Publications94

  1. Zhan P, Suo L, Qian Q, Shen X, Qiu L, Yu L, et al. Chlamydia pneumoniae infection and lung cancer risk: a meta-analysis. Eur J Cancer. 2011;47:742-7 pubmed publisher
    ..22; 95% CI, 1.06-1.41) and the IgA ? 64 cutoff group (OR, 2.35; 95% CI, 1.88-2.93). In conclusion, C. pneumoniae infection is associated with an increased risk for lung cancer, higher titre may be a better predictor of lung cancer risk...
  2. Crother T, Schröder N, Karlin J, Chen S, Shimada K, Slepenkin A, et al. Chlamydia pneumoniae infection induced allergic airway sensitization is controlled by regulatory T-cells and plasmacytoid dendritic cells. PLoS ONE. 2011;6:e20784 pubmed publisher
    ..We conclude that Tregs and pDCs are critical determinants regulating CP infection-induced allergic sensitization. Furthermore, TLR2 and TLR4 signaling during CP infection may play a regulatory role through the modulation of Tregs. ..
  3. Lin F, Lin Y, Huang C, Chang Y, Tsao N, Chang N, et al. GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, induces lectin-like oxidized low-density lipoprotein receptor 1 expression in endothelial cells and enhances atherogenesis in hypercholesterolemic rabbits. J Immunol. 2011;186:4405-14 pubmed publisher
    ..The GroEL1 protein of C. pneumoniae may contribute to vascular inflammation and cardiovascular disorders...
  4. Park S, Kwon S, Lee S, Kim Y, Hwang K, Kang Y, et al. Identification of immunogenic antigen candidate for Chlamydophila pneumoniae diagnosis. J Proteome Res. 2009;8:2933-43 pubmed publisher
    b>Chlamydophila pneumoniae is a Gram-negative intracellular obligate human pathogen and accounts for 5-10% of cases of community-acquired pneumonia...
  5. Nazzal D, Therville N, Yacoub Youssef H, Garcia V, Thomsen M, Levade T, et al. Apolipoprotein E-deficient mice develop an anti-Chlamydophila pneumoniae T helper 2 response and resist vascular infection. J Infect Dis. 2010;202:782-90 pubmed publisher
    ..No information is available about its impact on the immune response toward Chlamydophila pneumoniae. Apolipoprotein E (apoE)-deficient and wild-type mice fed a normal diet were infected with a single ..
  6. Cho M, Kim H, An D, Lee M, Noh S, Kim M, et al. Comparison of sputum and nasopharyngeal swab specimens for molecular diagnosis of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. Ann Lab Med. 2012;32:133-8 pubmed publisher
    ..we compared sputum and nasopharyngeal swabs (NPS) for use in detection of Mycoplasma pneumoniae (MP), Chlamydophila pneumoniae (CP), and Legionella pneumophila (LP), using Seeplex PneumoBacter ACE Detection Assay (PneumoBacter; ..
  7. Crother T, Ma J, Jupelli M, Chiba N, Chen S, Slepenkin A, et al. Plasmacytoid dendritic cells play a role for effective innate immune responses during Chlamydia pneumoniae infection in mice. PLoS ONE. 2012;7:e48655 pubmed publisher
    ..Thus pDCs in the lung and the draining lymph node appear to have different roles and phenotypes during acute CP infection and may play a role in host immune responses. ..
  8. Gaballah A, Kloeckner A, Otten C, Sahl H, Henrichfreise B. Functional analysis of the cytoskeleton protein MreB from Chlamydophila pneumoniae. PLoS ONE. 2011;6:e25129 pubmed publisher
    ..Our findings suggest that MreB is involved in tethering biosynthesis of lipid II and as such may be necessary for maintaining a functional divisome machinery in Chlamydiaceae. ..
  9. Bossone E, Trimarchi S, Esposito G, Aliberti S, Citro R, Allegra L, et al. Chlamydia pneumoniae and acute aortic syndrome: a call for a multi-institutional study. Monaldi Arch Chest Dis. 2008;70:68-70 pubmed
    ..pneumoniae and acute aortic dissection. Well-designed large prospective studies are needed in order to clarify the pathophysiologic role of CP infection in acute and chronic aortic disease...
  10. Mei C, He P, Cheng B, Liu W, Wang Y, Wan J. Chlamydia pneumoniae induces macrophage-derived foam cell formation via PPAR alpha and PPAR gamma-dependent pathways. Cell Biol Int. 2009;33:301-8 pubmed publisher
    ..These results first reveal that C. pneumoniae induces foam cell formation via PPAR alpha and PPAR gamma-dependent pathway, which may contribute to its pro-atherogenic properties. ..
  11. Hedayat D, Jebeli M, Mandegar M, Bagheri J, Nabavi S, Eghtesadi Araghi P, et al. The association between Chlamydia pneumoniae DNA in arherosclerotic plaque and major risk factors in patients undergoing coronary artery bypass grafting. Kardiol Pol. 2009;67:981-6 pubmed
  12. Puolakkainen M. Innate immunity and vaccines in chlamydial infection with special emphasis on Chlamydia pneumoniae. FEMS Immunol Med Microbiol. 2009;55:167-77 pubmed publisher
    ..Modern technologies and data obtained using different 'omics' techniques (genomics, proteomics, transcriptomics and immunomics) might help in designing novel, more efficient vaccines, hopefully also against chlamydial infections. ..
  13. Pignanelli S, Shurdhi A, Delucca F, Donati M. Simultaneous use of direct and indirect diagnostic techniques in atypical respiratory infections from Chlamydophila pneumoniae and Mycoplasma pneumoniae. J Clin Lab Anal. 2009;23:206-9 pubmed publisher
    ..symptoms have been investigated using two real-time PCR methods: one assay for the single detection of Chlamydophila pneumoniae and Mycoplasma pneumoniae DNA and one commercially available real-time duplex PCR assay for the detection ..
  14. Satpathy G, Bhan A, Sharma A, Kar U. Detection of Chlamydophila pneumoniae (Chlamydia pneumoniae) in endarteroctomy specimens of coronary heart diseases patients. Indian J Med Res. 2008;128:658-62 pubmed
    ..pneumoniae and coronary artery disease would not be established by genome or antigen detection. However, C. pneumoniae antibodies were detected in more number of patients than controls. More studies are required to reach to a conclusion. ..
  15. Schröder N, Crother T, Naiki Y, Chen S, Wong M, Yilmaz A, et al. Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization. J Allergy Clin Immunol. 2008;122:595-602.e5 pubmed publisher
    ..A mechanistic reconciliation of these findings has not yet emerged. In particular, the role of innate immunity in this context is unclear...
  16. Stone C, Johnson D, Bulir D, Gilchrist J, Mahony J. Characterization of the putative type III secretion ATPase CdsN (Cpn0707) of Chlamydophila pneumoniae. J Bacteriol. 2008;190:6580-8 pubmed publisher
    ..b>Chlamydophila pneumoniae is a gram-negative, obligate intracellular pathogen that has the structural genes coding for a T3S system,..
  17. Agarwal A, Chander Y. Chronic Chlamydia pneumoniae infection and bronchial asthma: is there a link?. Indian J Med Microbiol. 2008;26:338-41 pubmed
    ..pneumoniae was more frequent in patients with asthma compared with control subjects. Our results support the correlation of bronchial asthma and chronic infection with C. pneumoniae in Indian population. ..
  18. Di Pietro M, Schiavoni G, Del Piano M, Shaik Y, Boscolo P, Caraffa A, et al. Chlamydia pneumoniae and atherosclerosis: the role of mast cells. J Biol Regul Homeost Agents. 2009;23:65-9 pubmed
    ..pneumoniae and mast cells and their potential role in plaque instability. In addition, in this paper we review the role of mast cells in innate immunity. ..
  19. Yasui Y, Yanatori I, Kawai Y, Miura K, Suminami Y, Hirota T, et al. Genomic screening for Chlamydophila pneumoniae-specific antigens using serum samples from patients with primary infection. FEMS Microbiol Lett. 2012;329:168-76 pubmed publisher
    b>Chlamydophila pneumoniae, an obligate intracellular human pathogen, causes respiratory tract infections. The most common techniques used for the serological diagnosis of C...
  20. Rivera J, Walduck A, Strugnell R, Sobey C, Drummond G. Chlamydia pneumoniae induces a pro-inflammatory phenotype in murine vascular smooth muscle cells independently of elevating reactive oxygen species. Clin Exp Pharmacol Physiol. 2012;39:218-26 pubmed publisher
    ..pneumoniae persistence within the cell. ..
  21. Mancini F, Savarino A, Losardo M, Cassone A, Ciervo A. Characterization of the serological response to phospholipase D protein of Chlamydophila pneumoniae in patients with acute coronary syndromes. Microbes Infect. 2009;11:367-73 pubmed publisher
    ..of this study was to evaluate the serological response to the recombinant phospholipase D protein of Chlamydophila pneumoniae (CpPLD) in patients with acute coronary syndromes (ACS) and infected by C. pneumoniae...
  22. Mousa A, Al Zaki A, Taha S, Bakhiet M. Induction of interleukin-18 in atherosclerotic patients: a role for Chlamydia pneumoniae. Med Princ Pract. 2009;18:105-10 pubmed publisher
  23. Alavi S, Ahmadi F, Abeshtan A. Is Chlamydia pneumoniae seropositivity associated with atherothrombotic cerebrovascular infarction?. J Infect Public Health. 2009;2:96-9 pubmed publisher
    ..Since these studies have reported controversial results, we performed this study to identify whether Cp-immunoglobulin was associated with atherothrombotic cerebrovascular infarction (ACI) in Iranian patients...
  24. Sorrentino R, Gray P, Chen S, Shimada K, Crother T, Arditi M. Plasmacytoid dendritic cells prevent cigarette smoke and Chlamydophila pneumoniae-induced Th2 inflammatory responses. Am J Respir Cell Mol Biol. 2010;43:422-31 pubmed publisher
    Smoking promotes the development of allergic asthma and pneumonia. Chlamydophila pneumoniae lung infection is associated with an increased risk for asthma, inducing an immune response regulated by dendritic cells (DCs)...
  25. Deniset J, Pierce G. Possibilities for therapeutic interventions in disrupting Chlamydophila pneumoniae involvement in atherosclerosis. Fundam Clin Pharmacol. 2010;24:607-17 pubmed publisher
    Strong sero-epidemiologic, pathologic, and experimental evidence suggests that Chlamydophila pneumoniae (Cpn) infection may play a causative role in the development of atherosclerosis...
  26. Maia I, Nicolau J, Machado M, Maia L, Takakura I, Rocha P, et al. Prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniae in different forms of coronary disease. Arq Bras Cardiol. 2009;92:405-11, 422-8, 439-45 pubmed
    ..Several infectious agents have been investigated since the association between atherosclerosis and infection was demonstrated; however, the results of these studies are contradictory...
  27. Shimada K, Crother T, Karlin J, Chen S, Chiba N, Ramanujan V, et al. Caspase-1 dependent IL-1? secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. PLoS ONE. 2011;6:e21477 pubmed publisher
    ..Interestingly, Caspase-1 activation during CP infection occurs with mitochondrial dysfunction indicating a possible mechanism involving the mitochondria for CP-induced inflammasome activation...
  28. Kurz H, Göpfrich H, Wabnegger L, Apfalter P. Role of Chlamydophila pneumoniae in children hospitalized for community-acquired pneumonia in Vienna, Austria. Pediatr Pulmonol. 2009;44:873-6 pubmed publisher
    No recent Austrian data are available on the epidemiology and morbidity of Chlamydophila pneumoniae (C. pneumoniae) as causative agent in youths and children hospitalized with community-acquired pneumonia (CAP)...
  29. Guvenc M, Midilli K, Inci E, Kuşkucu M, Tahamiler R, Ozergil E, et al. Lack of Chlamydophila pneumoniae and predominance of Alloiococcus otitidis in middle ear fluids of children with otitis media with effusion. Auris Nasus Larynx. 2010;37:269-73 pubmed publisher
    To investigate the presence of Chlamydophila pneumoniae and other bacterial pathogens in middle ear effusion samples obtained from children with otitis media with effusion (OME).
  30. Thurman K, Warner A, Cowart K, Benitez A, Winchell J. Detection of Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella spp. in clinical specimens using a single-tube multiplex real-time PCR assay. Diagn Microbiol Infect Dis. 2011;70:1-9 pubmed publisher
    ..This procedure may allow for a practical and efficient means to test respiratory clinical specimens for atypical pneumonia agents in health care settings and facilitate an appropriate public health response to outbreaks...
  31. Mannonen L, Markkula E, Puolakkainen M. Analysis of Chlamydia pneumoniae infection in mononuclear cells by reverse transcription-PCR targeted to chlamydial gene transcripts. Med Microbiol Immunol. 2011;200:143-54 pubmed publisher
  32. Papaetis G, Anastasakou E, Orphanidou D. Chlamydophila pneumoniae infection and COPD: more evidence for lack of evidence?. Eur J Intern Med. 2009;20:579-85 pubmed publisher
    b>Chlamydophila pneumoniae has been recognized as a common cause of respiratory tract infections affecting all age groups. The organism has been implicated as an infectious trigger for acute exacerbations of COPD...
  33. Gagliardi R, Caiaffa Filho H. Chlamydia pneumoniae and stroke: is there a direct relationship?. Arq Neuropsiquiatr. 2009;67:600-4 pubmed
    ..To investigate the possible relationship between atherothrombotic stroke and Chlamydia pneumoniae...
  34. Reverter J, Tassies D, Alonso N, Pellitero S, Sanmartí A, Reverter J. Non-detectable Chlamydophila pneumoniae DNA in peripheral leukocytes in type 2 diabetes mellitus patients with and without carotid atherosclerosis. Med Clin (Barc). 2012;138:11-4 pubmed publisher
    To study Chlamydophila pneumoniae DNA (CP-DNA) in leukocytes measured by real-time polymerase chain reaction (PCR) in patients with type 2 diabetes mellitus (DM2) with different degrees of atherosclerosis, a cross-sectional protocol was ..
  35. Di Pietro M, Tramonti A, De Santis F, De Biase D, Schiavoni G, Filardo S, et al. Analysis of gene expression in penicillin G induced persistence of Chlamydia pneumoniae. J Biol Regul Homeost Agents. 2012;26:277-84 pubmed
    ..In conclusion, the Chlamydial expression pattern of hctA, hctB, and htrA genes may be helpful to identify target molecules to diagnose and treat Chlamydia-associated chronic diseases...
  36. Nyström Rosander C, Frisk P, Edvinsson M, Hjelm E, Thelin S, Friman G, et al. Thoracic aortic aneurysm patients with Chlamydophila pneumoniae infection showed a shift in trace element levels in serum and diseased aortic tissue. J Trace Elem Med Biol. 2009;23:100-6 pubmed publisher
    ..DNA from the intracellular respiratory pathogen Chlamydophila pneumoniae (C...
  37. Patel K, Vicencio A, Du Z, Tsirilakis K, Salva P, Webley W. Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma. Pediatr Infect Dis J. 2010;29:1093-8 pubmed
    ..Chlamydia pneumoniae has been implicated in asthma, possibly by induction of interleukin (IL-8). We hypothesized that IL-8 is increased in the bronchoalveolar lavage (BAL) fluid from children with asthma and C. pneumoniae...
  38. Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, et al. Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells. PLoS ONE. 2012;7:e30379 pubmed publisher
    b>Chlamydophila pneumoniae causes acute respiratory tract infections and has been associated with development of asthma and atherosclerosis...
  39. Bermudez Fajardo A, Stark A, El Kadri R, Penichet M, Hölzle K, Wittenbrink M, et al. The effect of Chlamydophila pneumoniae Major Outer Membrane Protein (MOMP) on macrophage and T cell-mediated immune responses. Immunobiology. 2011;216:152-63 pubmed publisher
    The Major Outer Membrane Protein (MOMP) belongs to the membrane complex of cysteine-rich proteins of Chlamydophila pneumoniae. Although MOMP can elicit strong immune responses it fails to confer long-term protection against infection in ..
  40. Tiszlavicz Z, Endresz V, Németh B, Megyeri K, Orosz L, Seprényi G, et al. Inducible expression of human ?-defensin 2 by Chlamydophila pneumoniae in brain capillary endothelial cells. Innate Immun. 2011;17:463-9 pubmed publisher
    Defensins are an important family of natural antimicrobial peptides. Chlamydophila pneumoniae, a common cause of acute respiratory infection, has a tendency to cause persistent inflammatory diseases such as atherosclerosis, which may lead ..
  41. Mölleken K, Schmidt E, Hegemann J. Members of the Pmp protein family of Chlamydia pneumoniae mediate adhesion to human cells via short repetitive peptide motifs. Mol Microbiol. 2010;78:1004-17 pubmed publisher
    ..Our findings imply that Pmp6, Pmp20 and Pmp21 act as adhesins, are vital during infection and thus represent promising vaccine candidates...
  42. Chaturvedi A, Gaydos C, Agreda P, Holden J, Chatterjee N, Goedert J, et al. Chlamydia pneumoniae infection and risk for lung cancer. Cancer Epidemiol Biomarkers Prev. 2010;19:1498-505 pubmed publisher
  43. Di Pietro M, Filardo S, Cazzavillan S, Segala C, Bevilacqua P, Bonoldi E, et al. Could past Chlamydial vascular infection promote the dissemination of Chlamydia pneumoniae to the brain?. J Biol Regul Homeost Agents. 2013;27:155-64 pubmed
    ..It will be important for current and future researches to perform large-scale prospective studies on cardiovascular patients with chlamydial vascular infection in order to evaluate the long-term pathological alterations of the brain...
  44. Mitchell C, Mathews S, Theodoropoulos C, Timms P. In vitro characterisation of koala Chlamydia pneumoniae: morphology, inclusion development and doubling time. Vet Microbiol. 2009;136:91-9 pubmed publisher
    ..Our findings have provided new insights and identified key differences in the in vitro doubling time, size and morphology of an animal C. pneumoniae isolate...
  45. Mitchell S, Budhiraja S, Thurman K, Lanier Thacker W, Winchell J. Evaluation of two real-time PCR chemistries for the detection of Chlamydophila pneumoniae in clinical specimens. Mol Cell Probes. 2009;23:309-11 pubmed publisher
    b>Chlamydophila pneumoniae is an atypical bacterial respiratory pathogen that is responsible for approximately 3-10% of community-acquired pneumonia cases...
  46. Klos A, Thalmann J, Peters J, Gerard H, Hudson A. The transcript profile of persistent Chlamydophila (Chlamydia) pneumoniae in vitro depends on the means by which persistence is induced. FEMS Microbiol Lett. 2009;291:120-6 pubmed publisher
    ..Each model system studied here can provide information regarding the molecular characteristics of persistent C. pneumoniae infection. However, we do not know which aspect(s) of which model correspond to in vivo disease or other contexts...
  47. Kreutmayer S, Csordas A, Kern J, Maass V, Almanzar G, Offterdinger M, et al. Chlamydia pneumoniae infection acts as an endothelial stressor with the potential to initiate the earliest heat shock protein 60-dependent inflammatory stage of atherosclerosis. Cell Stress Chaperones. 2013;18:259-68 pubmed publisher
    ..pneumoniae as a potent primary endothelial stressor for arterial endothelial cells leading to enrichment of hHSP60 on the cellular membrane and, as such, a potential initiator of atherosclerosis...
  48. Hongliang C, Zhou Z, Zhan H, Yanhua Z, Zhongyu L, Yingbiao L, et al. Serodiagnosis of Chlamydia pneumoniae infection using three inclusion membrane proteins. J Clin Lab Anal. 2010;24:55-61 pubmed publisher
    ..pneumoniae infection...
  49. Prakash H, Albrecht M, Becker D, Kuhlmann T, Rudel T. Deficiency of XIAP leads to sensitization for Chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice. J Biol Chem. 2010;285:20291-302 pubmed publisher
    Obligate intracellular Chlamydophila pneumoniae induce apoptosis resistance in host cells to escape eradication by immune effector cells...
  50. Shima K, Kuhlenbäumer G, Rupp J. Chlamydia pneumoniae infection and Alzheimer's disease: a connection to remember?. Med Microbiol Immunol. 2010;199:283-9 pubmed publisher
    ..We will also present three mutually non-exclusive hypotheses how Cpn might contribute to the pathogenesis of AD...
  51. Roblin P, Kohlhoff S, Parker C, Hammerschlag M. In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae. Antimicrob Agents Chemother. 2010;54:1358-9 pubmed publisher
    ..pneumoniae were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by CEM-101 were 0.25 microg/ml (ranges, 0.125 to 0.5 microg/ml for C. trachomatis and 0.25 to 1.0 microg/ml for C. pneumoniae)...
  52. Monno R, Fumarola L, Trerotoli P, Giannelli G, Correale M, Brunetti D, et al. Seroprevalence of Chlamydophila pneumoniae in ischaemic heart disease. New Microbiol. 2010;33:381-5 pubmed
    We investigated the presence of Chlamydophila pneumoniae antibodies in 125 patients with cardiovascular disease and in 128 controls. C. pneumoniae antibodies were measured by microimmunofluorescence assay...
  53. She R, Thurber A, Hymas W, Stevenson J, Langer J, Litwin C, et al. Limited utility of culture for Mycoplasma pneumoniae and Chlamydophila pneumoniae for diagnosis of respiratory tract infections. J Clin Microbiol. 2010;48:3380-2 pubmed publisher
    We assessed the utility of culture for Mycoplasma pneumoniae and Chlamydophila pneumoniae to diagnose respiratory tract infections. Compared to PCR and IgM serology, culture was less sensitive and had extremely low yield...
  54. Rodriguez N, Lang R, Wantia N, Cirl C, Ertl T, Dürr S, et al. Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK. J Leukoc Biol. 2008;84:1585-93 pubmed publisher
    ..NO plays an important role in host defense against intracellular bacteria including Chlamydophila pneumoniae as a result of its microbicidal activity. In MyD88-deficient mice, which succumb to C...
  55. Timms P, Good D, Wan C, Theodoropoulos C, Mukhopadhyay S, Summersgill J, et al. Differential transcriptional responses between the interferon-gamma-induction and iron-limitation models of persistence for Chlamydia pneumoniae. J Microbiol Immunol Infect. 2009;42:27-37 pubmed
    ..This study was performed to compare the interferon-gamma (IFN-gamma) induction and iron-limitation models of persistence for Chlamydia spp. to investigate the common and unique transcriptional pathways involved...
  56. Naiki Y, Sorrentino R, Wong M, Michelsen K, Shimada K, Chen S, et al. TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol. 2008;181:7176-85 pubmed
    ..pneumoniae infection...
  57. Polkinghorne A, Ziegler U, Gonz lez Hern ndez Y, Pospischil A, Timms P, Vaughan L. Chlamydophila pneumoniae HflX belongs to an uncharacterized family of conserved GTPases and associates with the Escherichia coli 50S large ribosomal subunit. Microbiology. 2008;154:3537-46 pubmed publisher
    ..here what appears to be the first analysis of a HflX family GTPase using a predicted homologue from Chlamydophila pneumoniae. In agreement with phylogenetic predictions for members of this GTPase family, purified recombinant Cp...
  58. Borel N, Pospischil A, Dowling R, Dumrese C, Gaydos C, Bunk S, et al. Antigens of persistent Chlamydia pneumoniae within coronary atheroma from patients undergoing heart transplantation. J Clin Pathol. 2012;65:171-7 pubmed publisher
    ..Current theory suggests that C pneumoniae may persist at the site of infection via an alternative replicative form, known as an aberrant body...
  59. Al Bannawi A, Al Wesebai K, Taha S, Bakhiet M. Chlamydia pneumoniae induces chemokine expression by platelets in patients with atherosclerosis. Med Princ Pract. 2011;20:438-43 pubmed publisher
    ..In this study, the role of Chlamydia pneumoniae in triggering platelets to induce the inflammatory potential chemokines CCL3, CCL5, CCL7 and CXCL8 in atherosclerotic patients was investigated...
  60. Liu W, He P, Cheng B, Mei C, Wang Y, Wan J. Chlamydia pneumoniae disturbs cholesterol homeostasis in human THP-1 macrophages via JNK-PPAR? dependent signal transduction pathways. Microbes Infect. 2010;12:1226-35 pubmed publisher
    ..pneumoniae infections disturb cholesterol homeostasis in human THP-1 macrophages and C. pneumoniae infection disturbs cholesterol homeostasis via JNK-PPAR? dependent signal transduction pathways...
  61. Hahn D, Peeling R. Airflow limitation, asthma, and Chlamydia pneumoniae-specific heat shock protein 60. Ann Allergy Asthma Immunol. 2008;101:614-8 pubmed publisher
    ..The pathogenesis of C trachomatis disease associations is thought to include molecular mimicry (autoimmunity), direct activation of the innate immune response via the CD14/toll-like receptor 4 complex, or both...
  62. Webley W, Tilahun Y, Lay K, Patel K, Stuart E, Andrzejewski C, et al. Occurrence of Chlamydia trachomatis and Chlamydia pneumoniae in paediatric respiratory infections. Eur Respir J. 2009;33:360-7 pubmed publisher
    ..To the current authors' knowledge, this is the first report of viable Chlamydia trachomatis in the lungs of children...
  63. Kern J, Maass V, Maass M. Chlamydia pneumoniae adversely modulates vascular cell properties by direct interaction with signalling cascades. Thromb Haemost. 2009;102:1064-70 pubmed publisher
    ..This review displays crucial mechanisms of Chlamydia pneumoniae-induced interactions with vascular host cell signalling cascades with an emphasis on mitogenic and inflammatory processes as well as target cell activation...
  64. Johnson D, Stone C, Bulir D, Coombes B, Mahony J. A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication. BMC Microbiol. 2009;9:218 pubmed publisher
    We have shown previously that Chlamydophila pneumoniae contains a dual-specific Ser/Thr protein kinase that phosphorylates CdsD, a structural component of the type III secretion apparatus...
  65. He P, Mei C, Cheng B, Liu W, Wang Y, Wan J. Chlamydia pneumoniae induces macrophage-derived foam cell formation by up-regulating acyl-coenzyme A: cholesterol acyltransferase 1. Microbes Infect. 2009;11:157-63 pubmed publisher
    ..These results first demonstrate that C. pneumoniae induces macrophage-derived foam cell formation by up-regulating ACAT1 expression via PPAR gamma-dependent pathway, which may contribute to its pro-atherogenic properties...
  66. Li X, Zhang L, Wang B, Zhang T, Ye J. Chlamydophila (Chlamydia) pneumoniae infection promotes vascular smooth muscle cell adhesion and migration through IQ domain GTPase-activating protein 1. Microb Pathog. 2012;53:207-13 pubmed publisher
    ..Taken together, our results suggest that C. pneumoniae infection may promote the adhesion and migration of VSMCs possibly by upregulating the IQGAP1 expression...
  67. Wang A, Al Kuhlani M, Johnston S, Ojcius D, Chou J, Dean D. Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection. Cell Microbiol. 2013;15:779-94 pubmed publisher
    ..These findings suggest that C. pneumoniae initiates signalling via TLR3 and MAPK that activate AP-1, a known immune activator in other bacteria not previously shown for chlamydiae, triggering inflammation linked to C. pneumoniae disease...
  68. Kēniņa V, Auce P, Millers A. The relationship between seropositivity against Chlamydia pneumoniae and stroke and its subtypes in a Latvian population. Medicina (Kaunas). 2011;47:657-60 pubmed
    ..This study showed that IgG seropositivity to Chlamydia pneumoniae was associated with stroke and all the analyzed etiological subtypes of stroke. ..
  69. Prochnau D, Rodel J, Prager K, Kuersten D, Heller R, Straube E, et al. Induced expression of lectin-like oxidized ldl receptor-1 in vascular smooth muscle cells following Chlamydia pneumoniae infection and its down-regulation by fluvastatin. Acta Microbiol Immunol Hung. 2010;57:147-55 pubmed publisher
    ..pneumoniae infection and atherosclerosis. The effect of lowering the LOX-1 expression by fluvastatin may provide a pharmacological option of limiting oxLDL uptake via its scavenger receptor...
  70. Jha H, Srivastava P, Sarkar R, Prasad J, Mittal A. Chlamydia pneumoniae IgA and elevated level of IL-6 may synergize to accelerate coronary artery disease. J Cardiol. 2008;52:140-5 pubmed publisher
    ..Also the physiological and baseline characteristics in IL-6 positive CAD patients were studied...
  71. Bellmann Weiler R, Martinz V, Kurz K, Engl S, Feistritzer C, Fuchs D, et al. Divergent modulation of Chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gamma. Immunobiology. 2010;215:842-8 pubmed publisher
    ..pneumoniae biology in endothelial, but not monocytic cells. Our results contribute to a better understanding of C. pneumoniae infection and its role in chronic inflammatory diseases such as atherosclerosis...
  72. Chen S, Sorrentino R, Shimada K, Bulut Y, Doherty T, Crother T, et al. Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation. J Immunol. 2008;181:7186-93 pubmed
    ..pneumoniae accelerates the development of atherosclerotic plaque and lends support to the proposal that LXR agonists might prove clinically useful in suppressing atherogenesis...
  73. Baumert J, Schmidt K, Eitner A, Straube E, Rödel J. Host cell cytokines induced by Chlamydia pneumoniae decrease the expression of interstitial collagens and fibronectin in fibroblasts. Infect Immun. 2009;77:867-76 pubmed publisher
    ..In atherosclerosis the inhibition of collagen synthesis by C. pneumoniae infection may promote plaque vulnerability, thereby increasing the risk of plaque rupture...
  74. Carter J, Gerard H, Espinoza L, Ricca L, Valeriano J, Snelgrove J, et al. Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis. Arthritis Rheum. 2009;60:1311-6 pubmed publisher
    ..The aim of the present study was to assess the prevalence of synovial Chlamydia trachomatis and Chlamydia pneumoniae infections in patients with chronic undifferentiated spondylarthritis (uSpA)...
  75. Sasaki A, Ouchi K, Makata H, Hashimoto K, Matsubara T, Furukawa S. The effect of inhaled corticosteroids on Chlamydophila pneumoniae and Mycoplasma pneumoniae infection in children with bronchial asthma. J Infect Chemother. 2009;15:99-103 pubmed publisher
    ..of this study was to clarify whether inhaled corticosteroids (ICSs) increased the infectious load of Chlamydophila pneumoniae and/or Mycoplasma pneumoniae in the respiratory tracts of asthmatic children...
  76. Palikhe A, Tiirola T, Puolakkainen M, Nieminen M, Saikku P, Leinonen M, et al. Chlamydia pneumoniae DNA is present in peripheral blood mononuclear cells during acute coronary syndrome and correlates with chlamydial lipopolysaccharide levels in serum. Scand J Infect Dis. 2009;41:201-5 pubmed publisher
    ..003). In conclusion, Chlamydia pneumoniae DNA is present during acute coronary syndrome and in the recovery period, but declines in stable state, suggesting a role of the bacterium in the acute phase of coronary syndrome...
  77. Wolf K, Plano G, Fields K. A protein secreted by the respiratory pathogen Chlamydia pneumoniae impairs IL-17 signalling via interaction with human Act1. Cell Microbiol. 2009;11:769-79 pubmed publisher
    ..We describe here a unique strategy employed by C. pneumoniae to achieve inhibition of NF?B activation via interaction of CP0236 with mammalian Act1...
  78. Tamari M, Harada M, Hirota T, Nakamura Y. Host molecular defense mechanisms against Chlamydophila pneumoniae and genetic studies of immune-response-related genes in asthma. Recent Pat Inflamm Allergy Drug Discov. 2009;3:17-25 pubmed
    b>Chlamydophila pneumoniae is an intracellular pathogen and a major cause of pneumonia that can cause chronic, persistent, and often asymptomatic, infections in target cells such as monocytes, macrophages, endothelial cells, fibroblasts, ..
  79. Korhonen J, Puolakkainen M, Haveri A, Tammiruusu A, Sarvas M, Lahesmaa R. Chlamydia pneumoniae entry into epithelial cells by clathrin-independent endocytosis. Microb Pathog. 2012;52:157-64 pubmed publisher
    ..In addition, our data indicate that SR-BI supports the growth of C. pneumoniae in epithelial cells...
  80. Karlsson L, Björck M, Parsson H, Wanhainen A. The association between serological markers for Chlamydophila pneumoniae and the development of abdominal aortic aneurysm. Ann Vasc Surg. 2011;25:322-6 pubmed publisher
    To investigate the association between serological markers for Chlamydophila pneumoniae (Cpn) and the development of abdominal aortic aneurysm (AAA) in a population-based case-control study.
  81. Damy S, Higuchi M, Timenetsky J, Reis M, Palomino S, Ikegami R, et al. Mycoplasma pneumoniae and/or Chlamydophila pneumoniae inoculation causing different aggravations in cholesterol-induced atherosclerosis in apoE KO male mice. BMC Microbiol. 2009;9:194 pubmed publisher
    ..The plaque area/intimal surface ratio was obtained by measuring all three segments. The adventitial inflammation was semiquantified (0 absent, 1 mild, 2 moderate, and 3 diffuse)...
  82. Diaz M, Winchell J. Detection of Mycoplasma pneumoniae and Chlamydophila pneumoniae directly from respiratory clinical specimens using a rapid real-time polymerase chain reaction assay. Diagn Microbiol Infect Dis. 2012;73:278-80 pubmed publisher
    We developed a rapid real-time polymerase chain reaction assay for detecting Mycoplasma pneumoniae and Chlamydophila pneumoniae directly from respiratory specimens...
  83. Shimada K, Chen S, Dempsey P, Sorrentino R, Alsabeh R, Slepenkin A, et al. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog. 2009;5:e1000379 pubmed publisher
    Here we investigated the role of the Nod/Rip2 pathway in host responses to Chlamydophila pneumoniae-induced pneumonia in mice. Rip2(-/-) mice infected with C...
  84. Abromaitis S, Hefty P, Stephens R. Chlamydia pneumoniae encodes a functional aromatic amino acid hydroxylase. FEMS Immunol Med Microbiol. 2009;55:196-205 pubmed publisher
    ..The maintenance of this gene within a number of Chlamydia suggests that the enzyme may have an important role in shaping the metabolism or overall pathogenesis of these bacteria...
  85. Dreses Werringloer U, Bhuiyan M, Zhao Y, Gerard H, Whittum Hudson J, Hudson A. Initial characterization of Chlamydophila (Chlamydia) pneumoniae cultured from the late-onset Alzheimer brain. Int J Med Microbiol. 2009;299:187-201 pubmed publisher
    ..This observation indicated that the brain isolates are more closely related to respiratory than to vascular/atheroma strains of C. pneumoniae...