chlamydia muridarum

Summary

Summary: Species of CHLAMYDIA causing pneumonitis in mice and hamsters. These isolates formerly belonged to CHLAMYDIA TRACHOMATIS.

Top Publications

  1. Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton M, et al. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J Immunol. 2009;183:1291-300 pubmed publisher
    ..early in the innate immunity phase after an intranasal infection with the obligate intracellular pathogen Chlamydia muridarum. The airway IL-17, which peaked at 48 h after infection, was dependent on live chlamydial organism ..
  2. Coers J, Bernstein Hanley I, Grotsky D, Parvanova I, Howard J, Taylor G, et al. Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. J Immunol. 2008;180:6237-45 pubmed
    ..the human pathogen Chlamydia trachomatis but fails to control growth of the closely related mouse pathogen Chlamydia muridarum. The ability of mouse cells to resist C...
  3. Kaiko G, Phipps S, Hickey D, Lam C, Hansbro P, Foster P, et al. Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity. J Immunol. 2008;180:2225-32 pubmed
    ..In the present study, we show that Chlamydia muridarum infection of murine bone marrow-derived dendritic cells (BMDC) modulates the phenotype, cytokine secretion ..
  4. Rey Ladino J, Jiang X, Gabel B, Shen C, Brunham R. Survival of Chlamydia muridarum within dendritic cells. Infect Immun. 2007;75:3707-14 pubmed
    ..Together, these results raise the possibility that Chlamydia-infected DCs may be central to the maintenance of T-cell memory that underlies both immunity and immunopathology. ..
  5. Nagarajan U, Sikes J, Prantner D, Andrews C, Frazer L, Goodwin A, et al. MyD88 deficiency leads to decreased NK cell gamma interferon production and T cell recruitment during Chlamydia muridarum genital tract infection, but a predominant Th1 response and enhanced monocytic inflammation are associated with infection resolu. Infect Immun. 2011;79:486-98 pubmed publisher
    We have previously shown that MyD88 knockout (KO) mice exhibit delayed clearance of Chlamydia muridarum genital infection compared to wild-type (WT) mice...
  6. Tang L, Yang Z, Zhang H, Zhou Z, Arulanandam B, Baseman J, et al. Induction of protective immunity against Chlamydia muridarum intracervical infection in DBA/1j mice. Vaccine. 2014;32:1407-13 pubmed publisher
    We previously reported that intracervical inoculation with Chlamydia muridarum induced hydrosalpinx in DBA/1j mice, but intravaginal inoculation failed to do so...
  7. Perfettini J, Ojcius D, Andrews C, Korsmeyer S, Rank R, Darville T. Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response. J Biol Chem. 2003;278:9496-502 pubmed
    ..Here we investigate the effect of BAX on infection by the sexually transmitted pathogen, Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis)...
  8. Peng B, Lu C, Tang L, Yeh I, He Z, Wu Y, et al. Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum. BMC Infect Dis. 2011;11:347 pubmed publisher
    ..trachomatis organisms. ..
  9. Murthy A, Chambers J, Meier P, Zhong G, Arulanandam B. Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production. Infect Immun. 2007;75:666-76 pubmed
    ..IL-12) (rCPAF+IL-12 immunization) was used to assess the protective immunity against genital Chlamydia muridarum infection in BALB/c mice...

More Information

Publications79

  1. Johnson R, Yu H, Kerr M, Slaven J, Karunakaran K, Brunham R. PmpG303-311, a protective vaccine epitope that elicits persistent cellular immune responses in Chlamydia muridarum-immune mice. Infect Immun. 2012;80:2204-11 pubmed publisher
    ..Previous studies have shown that CD4 T cells are necessary and sufficient to clear primary Chlamydia muridarum genital tract infections in the mouse model, making a protective CD4 T cell response a logical endpoint for ..
  2. Yu H, Jiang X, Shen C, Karunakaran K, Brunham R. Novel Chlamydia muridarum T cell antigens induce protective immunity against lung and genital tract infection in murine models. J Immunol. 2009;182:1602-8 pubmed
    ..8 MHC class II (I-A(b)) -bound Chlamydia peptides eluted from dendritic cells (DCs) infected with Chlamydia muridarum. In this study we cloned and purified the source proteins that contained each of these peptides and ..
  3. Farris C, Morrison S, Morrison R. CD4+ T cells and antibody are required for optimal major outer membrane protein vaccine-induced immunity to Chlamydia muridarum genital infection. Infect Immun. 2010;78:4374-83 pubmed publisher
    ..Female mice were first vaccinated with Chlamydia muridarum major outer membrane protein (MOMP) plus the adjuvants CpG-1826 and Montanide ISA 720; then they were ..
  4. Guo F, Yu X. Separate base usages of genes located on the leading and lagging strands in Chlamydia muridarum revealed by the Z curve method. BMC Genomics. 2007;8:366 pubmed
    ..This work aims to investigate the strand biases in Chlamydia muridarum genome and show the potential of the Z curve method for quantitatively differentiating genes on the leading ..
  5. Derbigny W, Hong S, Kerr M, Temkit M, Johnson R. Chlamydia muridarum infection elicits a beta interferon response in murine oviduct epithelial cells dependent on interferon regulatory factor 3 and TRIF. Infect Immun. 2007;75:1280-90 pubmed
    ..Antagonism of either IRF-3 or TRIF signaling significantly decreased IFN-beta production. These data implicate TLR3, or an unknown PRR utilizing TRIF, as the source of IFN-beta production by Chlamydia-infected oviduct epithelial cells. ..
  6. Jiao L, Gao X, Joyee A, Zhao L, Qiu H, Yang M, et al. NK cells promote type 1 T cell immunity through modulating the function of dendritic cells during intracellular bacterial infection. J Immunol. 2011;187:401-11 pubmed publisher
    ..We found that the NK cell-depleted mice showed exacerbated disease after respiratory tract Chlamydia muridarum infection, which was correlated with altered T cell cytokine profile. Furthermore, DC from C...
  7. Hansen J, Jensen K, Follmann F, Agger E, Theisen M, Andersen P. Liposome delivery of Chlamydia muridarum major outer membrane protein primes a Th1 response that protects against genital chlamydial infection in a mouse model. J Infect Dis. 2008;198:758-67 pubmed publisher
    ..C57BL/6 mice vaccinated with native refolded Chlamydia muridarum major outer membrane protein (MOMP) adjuvanted with either Th1-promoting cationic adjuvant formulation 1 (..
  8. Li W, Murthy A, Guentzel M, Seshu J, Forsthuber T, Zhong G, et al. Antigen-specific CD4+ T cells produce sufficient IFN-gamma to mediate robust protective immunity against genital Chlamydia muridarum infection. J Immunol. 2008;180:3375-82 pubmed
    ..bacterial killing; however, IFN-gamma-deficient mice exhibit suboptimal late phase vaginal Chlamydia muridarum clearance, greater dissemination, and oviduct pathology...
  9. Brown T, David J, Acosta Ramirez E, Moore J, Lee S, Zhong G, et al. Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection. Vaccine. 2012;30:350-60 pubmed publisher
    ..disparities observed in humoral and cellular immune responses, both the heterologous and homologous prime-boost regimens conferred significant immune protection against genital Chlamydia muridarum challenge in C3H/HeN and BALB/c mice.
  10. Imtiaz M, Distelhorst J, Schripsema J, Sigar I, Kasimos J, Lacy S, et al. A role for matrix metalloproteinase-9 in pathogenesis of urogenital Chlamydia muridarum infection in mice. Microbes Infect. 2007;9:1561-6 pubmed
    ..We have previously reported that global inhibition of MMP in Chlamydia muridarum urogenital tract infection of susceptible strains of female mice impeded ascension of C...
  11. Andrew D, Cochrane M, Schripsema J, Ramsey K, Dando S, O Meara C, et al. The duration of Chlamydia muridarum genital tract infection and associated chronic pathological changes are reduced in IL-17 knockout mice but protection is not increased further by immunization. PLoS ONE. 2013;8:e76664 pubmed publisher
    ..muridarum genital infection and associated oviduct pathology are significantly attenuated, however neither infection or pathology can be reduced further by vaccination protocols that effectively protect WT mice. ..
  12. Zhang Y, Wang H, Ren J, Tang X, Jing Y, Xing D, et al. IL-17A synergizes with IFN-? to upregulate iNOS and NO production and inhibit chlamydial growth. PLoS ONE. 2012;7:e39214 pubmed publisher
    ..as a new proinflammatory cytokine, has been shown to play a protective role in host defense against Chlamydia muridarum (Cm) infection...
  13. Carey A, Cunningham K, Andrew D, Hafner L, Timms P, Beagley K. A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice. Vaccine. 2011;29:6505-13 pubmed publisher
    ..Using the female Chlamydia muridarum genital tract mouse model, we examined this aspect of vaccine development...
  14. Prantner D, Sikes J, Hennings L, Savenka A, Basnakian A, Nagarajan U. Interferon regulatory transcription factor 3 protects mice from uterine horn pathology during Chlamydia muridarum genital infection. Infect Immun. 2011;79:3922-33 pubmed publisher
    ..These data suggest that IRF3 has a role in protection from uterine horn pathology that is independent of its function in IFN-? expression...
  15. Zhao L, Gao X, Peng Y, Joyee A, Bai H, Wang S, et al. Differential modulating effect of natural killer (NK) T cells on interferon-? production and cytotoxic function of NK cells and its relationship with NK subsets in Chlamydia muridarum infection. Immunology. 2011;134:172-84 pubmed publisher
    ..Our results showed that both NKT and NK cells became activated and produced IFN-? following Chlamydia muridarum infection in vitro and in vivo...
  16. Jayarapu K, Kerr M, Katschke A, Johnson R. Chlamydia muridarum-specific CD4 T-cell clones recognize infected reproductive tract epithelial cells in an interferon-dependent fashion. Infect Immun. 2009;77:4469-79 pubmed publisher
    ..In the experimental mouse model, CD4 T cells are necessary and sufficient to clear Chlamydia muridarum genital tract infections...
  17. Shimazaki K, Wadehra M, Forbes A, Chan A, Goodglick L, Kelly K, et al. Epithelial membrane protein 2 modulates infectivity of Chlamydia muridarum (MoPn). Microbes Infect. 2007;9:1003-10 pubmed
    ..Here we show that infectivity of the Chlamydia muridarum (MoPn) is associated with host cellular expression of EMP2 in multiple cell lines...
  18. Lu C, Zeng H, Li Z, Lei L, Yeh I, Wu Y, et al. Protective immunity against mouse upper genital tract pathology correlates with high IFN? but low IL-17 T cell and anti-secretion protein antibody responses induced by replicating chlamydial organisms in the airway. Vaccine. 2012;30:475-85 pubmed publisher
    ..we compared protection efficacy in mice immunized intranasally or intramuscularly with live or inactivated Chlamydia muridarum organisms...
  19. Skelding K, Hickey D, Horvat J, Bao S, Roberts K, Finnie J, et al. Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection. Vaccine. 2006;24:355-66 pubmed
    ..The best protection was obtained following IN immunization and correlated with IFNgamma production by mononuclear cells in lung-draining LN and MOMP-specific IgA in BAL...
  20. Asquith K, Horvat J, Kaiko G, Carey A, Beagley K, Hansbro P, et al. Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts. PLoS Pathog. 2011;7:e1001339 pubmed publisher
    ..Here, we show that IL-13 was produced in the lungs of mice rapidly after Chlamydia muridarum (Cmu) infection and promoted susceptibility to infection...
  21. Dong X, Liu Y, Chang X, Lei L, Zhong G. Signaling via tumor necrosis factor receptor 1 but not Toll-like receptor 2 contributes significantly to hydrosalpinx development following Chlamydia muridarum infection. Infect Immun. 2014;82:1833-9 pubmed publisher
  22. Horvat J, Starkey M, Kim R, Beagley K, Preston J, Gibson P, et al. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J Immunol. 2010;184:4159-69 pubmed publisher
    ..The effects of current and resolved Chlamydia muridarum infection during OVA sensitization on AAD were assessed and compared with uninfected and nonsensitized ..
  23. Cong Y, Jupelli M, Guentzel M, Zhong G, Murthy A, Arulanandam B. Intranasal immunization with chlamydial protease-like activity factor and CpG deoxynucleotides enhances protective immunity against genital Chlamydia muridarum infection. Vaccine. 2007;25:3773-80 pubmed
    ..Together, CpG dexoynucleotides are an efficacious alternative Th1 adjuvant with CPAF to induce protective anti-chlamydial immunity...
  24. Jiang X, Shen C, Yu H, Karunakaran K, Brunham R. Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection. Immunology. 2010;129:556-66 pubmed publisher
    ..the phenotypic basis for genetically determined differences in susceptibility and resistance to Chlamydia muridarum pulmonary infection using BALB/c and C57BL/6 mice. Following C...
  25. Murthy A, Li W, Chaganty B, Kamalakaran S, Guentzel M, Seshu J, et al. Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection. Infect Immun. 2011;79:2928-35 pubmed publisher
    ..and TNF-? are effector mechanisms of CD8(+) T cells, we evaluated the role of CD8(+) T cells during genital Chlamydia muridarum infection and oviduct sequelae...
  26. Yu H, Jiang X, Shen C, Karunakaran K, Jiang J, Rosin N, et al. Chlamydia muridarum T-cell antigens formulated with the adjuvant DDA/TDB induce immunity against infection that correlates with a high frequency of gamma interferon (IFN-gamma)/tumor necrosis factor alpha and IFN-gamma/interleukin-17 double-positive . Infect Immun. 2010;78:2272-82 pubmed publisher
  27. Lei L, Chen J, Hou S, Ding Y, Yang Z, Zeng H, et al. Reduced live organism recovery and lack of hydrosalpinx in mice infected with plasmid-free Chlamydia muridarum. Infect Immun. 2014;82:983-92 pubmed publisher
    Plasmid-free Chlamydia trachomatis and Chlamydia muridarum fail to induce severe pathology...
  28. Liu Y, Chen C, Gong S, Hou S, Qi M, Liu Q, et al. Transformation of Chlamydia muridarum reveals a role for Pgp5 in suppression of plasmid-dependent gene expression. J Bacteriol. 2014;196:989-98 pubmed publisher
    ..trachomatis to induce clinically relevant pathology in animal models. Chlamydia muridarum, which naturally infects mice, can induce hydrosalpinx in mice, a tubal pathology also seen in women ..
  29. He X, Nair A, Mekasha S, Alroy J, O Connell C, Ingalls R. Enhanced virulence of Chlamydia muridarum respiratory infections in the absence of TLR2 activation. PLoS ONE. 2011;6:e20846 pubmed publisher
    ..These data suggest that TLR2 has an anti-inflammatory function in the lung during Chlamydia infection, and that the role of TLR2 in mucosal inflammation varies at different mucosal surfaces...
  30. Murthy A, Cong Y, Murphey C, Guentzel M, Forsthuber T, Zhong G, et al. Chlamydial protease-like activity factor induces protective immunity against genital chlamydial infection in transgenic mice that express the human HLA-DR4 allele. Infect Immun. 2006;74:6722-9 pubmed
    ..allele (HLA-DR4 transgenic [tg] mice) to examine primary immune and CPAF-mediated responses against genital Chlamydia muridarum challenge...
  31. Qiu H, Fan Y, Joyee A, Wang S, Han X, Bai H, et al. Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophages. J Immunol. 2008;181:2092-102 pubmed
    ..IFNAR(-/-)) and wild-type control mice in susceptibility to Chlamydia trachomatis mouse pneumonitis (Chlamydia muridarum) lung infection. We found that the IFNAR(-/-) mice were significantly more resistant to C...
  32. Jupelli M, Guentzel M, Meier P, Zhong G, Murthy A, Arulanandam B. Endogenous IFN-gamma production is induced and required for protective immunity against pulmonary chlamydial infection in neonatal mice. J Immunol. 2008;180:4148-55 pubmed
    ..We examined the protective immune responses against intranasal Chlamydia muridarum challenge in 1-day-old C57BL/6 and BALB/c mice...
  33. Gracey E, Lin A, Akram A, Chiu B, Inman R. Intracellular survival and persistence of Chlamydia muridarum is determined by macrophage polarization. PLoS ONE. 2013;8:e69421 pubmed publisher
    ..Here we use Chlamydia muridarum and murine bone-marrow derived macrophages to show Chlamydia does not induce M2 polarization in macrophages ..
  34. Liu W, Dubinett S, Patterson S, Kelly K. COX-2 inhibition affects growth rate of Chlamydia muridarum within epithelial cells. Microbes Infect. 2006;8:478-86 pubmed
    ..addressed whether endogenous PGE2 alters chlamydial growth or apoptosis of epithelial cells infected with Chlamydia muridarum. PGE2 is secreted by infected host cells in the genital tract (GT)...
  35. Jupelli M, Selby D, Guentzel M, Chambers J, Forsthuber T, Zhong G, et al. The contribution of interleukin-12/interferon-gamma axis in protection against neonatal pulmonary Chlamydia muridarum challenge. J Interferon Cytokine Res. 2010;30:407-15 pubmed publisher
  36. Tang L, Zhang H, Lei L, Gong S, Zhou Z, Baseman J, et al. Oviduct infection and hydrosalpinx in DBA1/j mice is induced by intracervical but not intravaginal inoculation with Chlamydia muridarum. PLoS ONE. 2013;8:e71649 pubmed publisher
    ..The above findings also suggest that strategies aimed at reducing tubal infection may be most effective in blocking tubal pathology. ..
  37. Jayarapu K, Kerr M, Ofner S, Johnson R. Chlamydia-specific CD4 T cell clones control Chlamydia muridarum replication in epithelial cells by nitric oxide-dependent and -independent mechanisms. J Immunol. 2010;185:6911-20 pubmed publisher
    ..It is clear from knockout mice and T cell depletion studies using Chlamydia muridarum that MHC class II and CD4 T cells are critical for clearing bacteria from the murine genital tract...
  38. Derbigny W, Shobe L, Kamran J, Toomey K, Ofner S. Identifying a role for Toll-like receptor 3 in the innate immune response to Chlamydia muridarum infection in murine oviduct epithelial cells. Infect Immun. 2012;80:254-65 pubmed publisher
    ..Our OE cell data implicate TLR3 as an essential inducer of IFN-? and other inflammatory mediators by epithelial cells during Chlamydia infection and highlight the contribution of TLR3 to the inflammatory cytokine response...
  39. Yu H, Karunakaran K, Jiang X, Shen C, Andersen P, Brunham R. Chlamydia muridarum T cell antigens and adjuvants that induce protective immunity in mice. Infect Immun. 2012;80:1510-8 pubmed publisher
    ..The T cell antigens and adjuvants discovered in this study are of further interest in the development of a molecularly defined Chlamydia vaccine...
  40. Johnson R. Murine oviduct epithelial cell cytokine responses to Chlamydia muridarum infection include interleukin-12-p70 secretion. Infect Immun. 2004;72:3951-60 pubmed
    ..As expected, oviduct epithelial cells infected by Chlamydia muridarum produced a broad spectrum of chemokines, including CXCL16, and regulators of the acute-phase response, ..
  41. Derbigny W, Johnson R, Toomey K, Ofner S, Jayarapu K. The Chlamydia muridarum-induced IFN-? response is TLR3-dependent in murine oviduct epithelial cells. J Immunol. 2010;185:6689-97 pubmed publisher
  42. Chen L, Lei L, Chang X, Li Z, Lu C, Zhang X, et al. Mice deficient in MyD88 Develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection. J Immunol. 2010;184:2602-10 pubmed publisher
    ..molecule required for many innate immunity receptor-activated signaling pathways, was evaluated in a Chlamydia muridarum urogenital tract infection model...
  43. Lyons J, Ito J, Pena A, Morre S. Differences in growth characteristics and elementary body associated cytotoxicity between Chlamydia trachomatis oculogenital serovars D and H and Chlamydia muridarum. J Clin Pathol. 2005;58:397-401 pubmed
  44. Bai H, Cheng J, Gao X, Joyee A, Fan Y, Wang S, et al. IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. J Immunol. 2009;183:5886-95 pubmed publisher
    ..In this study, we investigated the role and mechanisms of IL-17/Th17 in host defense against Chlamydia muridarum, an obligate intracellular bacterium, lung infection...
  45. Moniz R, Chan A, Kelly K. Identification of dendritic cell subsets responding to genital infection by Chlamydia muridarum. FEMS Immunol Med Microbiol. 2009;55:226-36 pubmed publisher
    ..activation of two DC subsets: a classical CD11b+ (cDC) and plasmacytoid (pDC) during genital infection with Chlamydia muridarum. Genital infection induced an influx of cDC and pDC into the genital tract and its draining lymph node (..
  46. Murthy A, Chaganty B, Li W, Guentzel M, Chambers J, Seshu J, et al. A limited role for antibody in protective immunity induced by rCPAF and CpG vaccination against primary genital Chlamydia muridarum challenge. FEMS Immunol Med Microbiol. 2009;55:271-9 pubmed publisher
    ..Thus, antibodies may play a role in protection against chlamydial pathology after primary infection, but were largely dispensable in rCPAF+CpG-induced chlamydial clearance and reduction in pathology...
  47. O Connell C, Ingalls R, Andrews C, Scurlock A, Darville T. Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease. J Immunol. 2007;179:4027-34 pubmed
    ..In the murine model of genital disease with Chlamydia muridarum, TLR2 plays a role in both early production of inflammatory mediators and development of chronic oviduct ..
  48. Zeng H, Gong S, Hou S, Zou Q, Zhong G. Identification of antigen-specific antibody responses associated with upper genital tract pathology in mice infected with Chlamydia muridarum. Infect Immun. 2012;80:1098-106 pubmed publisher
    ..In the current study, 27 of 40 mice intravaginally infected with Chlamydia muridarum developed visible hydrosalpinges in the oviduct while the remaining 13 did not, although all infected mice ..
  49. Li Z, Lu C, Peng B, Zeng H, Zhou Z, Wu Y, et al. Induction of protective immunity against Chlamydia muridarum intravaginal infection with a chlamydial glycogen phosphorylase. PLoS ONE. 2012;7:e32997 pubmed publisher
    ..These results have demonstrated that intramuscular immunization of mice with purified proteins can be used to identify vaccine antigens for preventing intravaginal infection with C. trachomatis in humans...
  50. Nagarajan U, Prantner D, Sikes J, Andrews C, Goodwin A, Nagarajan S, et al. Type I interferon signaling exacerbates Chlamydia muridarum genital infection in a murine model. Infect Immun. 2008;76:4642-8 pubmed publisher
    ..role of type I IFNs during in vivo chlamydial genital infection, we examined the course and outcome of Chlamydia muridarum genital infection in mice genetically deficient in the receptor for type I IFNs (IFNAR(-/-) mice)...
  51. Bilenki L, Wang S, Yang J, Fan Y, Jiao L, Joyee A, et al. Adoptive transfer of CD8alpha+ dendritic cells (DC) isolated from mice infected with Chlamydia muridarum are more potent in inducing protective immunity than CD8alpha- DC. J Immunol. 2006;177:7067-75 pubmed
    ..trachomatis infection...
  52. Derbigny W, Kerr M, Johnson R. Pattern recognition molecules activated by Chlamydia muridarum infection of cloned murine oviduct epithelial cell lines. J Immunol. 2005;175:6065-75 pubmed
    ..and cytosolic nucleotide binding site/leucine-rich repeat proteins Nod1 and Nod2 in epithelial responses to Chlamydia muridarum infection. RT-PCR assays detected mRNA for TLR2 (TLRs 1 and 6), TLR3, and TLR5...
  53. Prantner D, Darville T, Sikes J, Andrews C, Brade H, Rank R, et al. Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages. Infect Immun. 2009;77:5334-46 pubmed publisher
    ..Although elicited mouse macrophages infected with Chlamydia muridarum in vitro secrete minimal IL-1beta, in vitro prestimulation of macrophages by Toll-like receptor (TLR) ..
  54. Yu H, Karunakaran K, Kelly I, Shen C, Jiang X, Foster L, et al. Immunization with live and dead Chlamydia muridarum induces different levels of protective immunity in a murine genital tract model: correlation with MHC class II peptide presentation and multifunctional Th1 cells. J Immunol. 2011;186:3615-21 pubmed publisher
    Mice that were intranasally vaccinated with live or dead Chlamydia muridarum with or without CpG-containing oligodeoxynucleotide 1862 elicited widely disparate levels of protective immunity to genital tract challenge...
  55. Shah A, Schripsema J, Imtiaz M, Sigar I, Kasimos J, Matos P, et al. Histopathologic changes related to fibrotic oviduct occlusion after genital tract infection of mice with Chlamydia muridarum. Sex Transm Dis. 2005;32:49-56 pubmed
    We sought to determine if intraluminal occluding fibrosis of the oviduct occurs after urogenital Chlamydia muridarum infection in mice.
  56. Maxion H, Liu W, Chang M, Kelly K. The infecting dose of Chlamydia muridarum modulates the innate immune response and ascending infection. Infect Immun. 2004;72:6330-40 pubmed
    Murine vaginal infection with the obligate intracellular bacterium Chlamydia muridarum is commonly used as a model for ascending Chlamydia infections of the human female genital tract...
  57. O Connell C, Nicks K. A plasmid-cured Chlamydia muridarum strain displays altered plaque morphology and reduced infectivity in cell culture. Microbiology. 2006;152:1601-7 pubmed
    ..Phenotypic characterization revealed that the cured derivative was unable to accumulate glycogen within intracytoplasmic inclusions. In addition, this strain formed small plaques at a reduced efficiency compared to the wild-type parent...
  58. Miyairi I, Ramsey K, Patton D. Duration of untreated chlamydial genital infection and factors associated with clearance: review of animal studies. J Infect Dis. 2010;201 Suppl 2:S96-103 pubmed publisher
    ..Future research should include use of humanized and nonmurine models that establish prolonged infection to improve understanding of chronic human infections...
  59. Johnson R, Kerr M, Slaven J. Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract. J Immunol. 2012;188:1896-904 pubmed publisher
    ..Studies utilizing the Chlamydia muridarum mouse model have shown that CD4 T cells are critical for clearing genital tract infections...
  60. Carey A, Cunningham K, Hafner L, Timms P, Beagley K. Effects of inoculating dose on the kinetics of Chlamydia muridarum genital infection in female mice. Immunol Cell Biol. 2009;87:337-43 pubmed publisher
    ..The murine model of female genital tract Chlamydia muridarum infection is frequently used as a model of human C. trachomatis reproductive tract infection...
  61. Cunningham K, Carey A, Lycke N, Timms P, Beagley K. CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa. J Reprod Immunol. 2009;81:34-8 pubmed publisher
    ..and mucosal antibodies, and reduces the level of chlamydial shedding following intravaginal challenge with Chlamydia muridarum. Thus, CTA1-DD is an effective adjuvant for vaccine development against Chlamydia trachomatis, and possibly ..
  62. Liu W, Kelly K. Prostaglandin E2 modulates dendritic cell function during chlamydial genital infection. Immunology. 2008;123:290-303 pubmed
    ..PGE2 is produced by epithelial cells lining the murine female reproductive tract during Chlamydia muridarum infection and likely manipulates the antichlamydial immune response during antigen uptake in the genital ..
  63. Karunakaran K, Rey Ladino J, Stoynov N, Berg K, Shen C, Jiang X, et al. Immunoproteomic discovery of novel T cell antigens from the obligate intracellular pathogen Chlamydia. J Immunol. 2008;180:2459-65 pubmed
    ..presented by MHC class II (I-A(b)) molecules from bone marrow-derived murine dendritic cells infected with Chlamydia muridarum. These MHC class II-bound peptides were recognized by Chlamydia-specific CD4 T cells harvested from immune ..
  64. Imtiaz M, Schripsema J, Sigar I, Kasimos J, Ramsey K. Inhibition of matrix metalloproteinases protects mice from ascending infection and chronic disease manifestations resulting from urogenital Chlamydia muridarum infection. Infect Immun. 2006;74:5513-21 pubmed
    ..We have previously reported enhanced expression of matrix metalloproteinases in Chlamydia muridarum urogenital tract infection of female mice...
  65. Champion C, Kickhoefer V, Liu G, Moniz R, Freed A, Bergmann L, et al. A vault nanoparticle vaccine induces protective mucosal immunity. PLoS ONE. 2009;4:e5409 pubmed publisher
    ..Here we report the use of a recombinant nanoparticle as a vaccine delivery platform against mucosal infections requiring T cell-mediated immunity for eradication...
  66. Ramsey K, Sigar I, Schripsema J, Shaba N, Cohoon K. Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of mice. Infect Immun. 2005;73:6962-73 pubmed
    ..To address this hypothesis, female C3H/HeN and C57BL/6 mice were infected intravaginally with Chlamydia muridarum. Uterine and oviduct tissues were assessed for transcription of MMP genes and their tissue inhibitors...
  67. Bilenki L, Wang S, Yang J, Fan Y, Joyee A, Yang X. NK T cell activation promotes Chlamydia trachomatis infection in vivo. J Immunol. 2005;175:3197-206 pubmed
    ..These data provide in vivo evidence for the involvement of NKT in a bacterial pathogenesis and its role in promoting Th2 responses during infection...
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    We previously demonstrated that plasmid-deficient Chlamydia muridarum retains the ability to infect the murine genital tract but does not elicit oviduct pathology because it fails to activate Toll-like receptor 2 (TLR2)...
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    ..The current outlook on the role of IL-23-IL-17 pathway in protective immunity to intracellular pathogens is discussed here...
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    Type I IFN signaling has recently been shown to be detrimental to the host during infection with Chlamydia muridarum in both mouse lung and female genital tract...