propionibacterium acnes

Summary

Summary: A bacteria isolated from normal skin, intestinal contents, wounds, blood, pus, and soft tissue abscesses. It is a common contaminant of clinical specimens, presumably from the skin of patients or attendants.

Top Publications

  1. Lomholt H, Kilian M. Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne. PLoS ONE. 2010;5:e12277 pubmed publisher
    The involvement of Propionibacterium acnes in the pathogenesis of acne is controversial, mainly owing to its dominance as an inhabitant of healthy skin...
  2. Lee Y, Choi H, Kang T, Kim H, Chung M, Park Y. CBT-SL5, a bacteriocin from Enterococcus faecalis, suppresses the expression of interleukin-8 induced by Propionibacterium acnes in cultured human keratinocytes. J Microbiol Biotechnol. 2008;18:1308-16 pubmed
    b>Propionibacterium acnes is known to play a pivotal role in the pathogenesis of acne vulgaris. CBT-SL5 is one of the antimicrobial peptides from Enterococcus faecalis SL5, and it has shown antimicrobial activity against P. acnes...
  3. Takenaka Y, Hayashi N, Takeda M, Ashikaga S, Kawashima M. Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes. J Dermatol. 2012;39:350-4 pubmed publisher
    ..To assess growth inhibitory and bactericidal effects of glycolic acid on Propionibacterium acnes in vitro, we used an agar diffusion method and a time-kill method...
  4. Sugisaki H, Yamanaka K, Kakeda M, Kitagawa H, Tanaka K, Watanabe K, et al. Increased interferon-gamma, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris: host response but not bacterial species is the determinant factor of the disease. J Dermatol Sci. 2009;55:47-52 pubmed publisher
    ..keratinization of hair epithelium, bacterial overgrowth and immunological mechanisms; the role of Propionibacterium acnes (P. acnes) is particularly important...
  5. Hager B, Strauss W, Falk H. Cationic hypericin derivatives as novel agents with photobactericidal activity: synthesis and photodynamic inactivation of Propionibacterium acnes. Photochem Photobiol. 2009;85:1201-6 pubmed publisher
    ..Photobactericidal activity was assessed using Propionibacterium acnes. The quaternary N,N,N-trimethyl-anilinium derivative displayed a pronounced photodynamic inactivation of ..
  6. Liu P, Phan J, Tang D, Kanchanapoomi M, Hall B, Krutzik S, et al. CD209(+) macrophages mediate host defense against Propionibacterium acnes. J Immunol. 2008;180:4919-23 pubmed
    b>Propionibacterium acnes is a major etiological factor of acne, triggering an inflammatory response in part through the activation of TLR2. In this study, we demonstrate that activation of peripheral blood monocytes with P...
  7. Michalak Stoma A, Tabarkiewicz J, Olender A, Juszkiewicz Borowiec M, Stoma F, Pietrzak A, et al. The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells. Folia Histochem Cytobiol. 2008;46:535-9 pubmed publisher
    b>Propionibacterium acnes (P. acnes) has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder...
  8. Lood R, Collin M. Characterization and genome sequencing of two Propionibacterium acnes phages displaying pseudolysogeny. BMC Genomics. 2011;12:198 pubmed publisher
    b>Propionibacterium acnes is a Gram positive rod inhabiting the human skin that also infects orthopaedic implants and is associated with acne vulgaris. Previously, one lytic bacteriophage, PA6, from P...
  9. Fu S, Sun C, Tao X, Ren Y. Anti-in?ammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes. Nat Prod Res. 2012;26:1746-9 pubmed publisher
    ..Based on the obtained results, it can be suggested that these active constituents are potential acne-mitigating candidates for cosmetic applications. ..

More Information

Publications135 found, 100 shown here

  1. Levy P, Fenollar F, Stein A, Borrione F, Cohen E, Lebail B, et al. Propionibacterium acnes postoperative shoulder arthritis: an emerging clinical entity. Clin Infect Dis. 2008;46:1884-6 pubmed publisher
    The purpose of this study, which involved 276 patients, was to report the importance of Propionibacterium acnes in shoulder infections. The proportion of patients with shoulder infection who had infection due to P...
  2. Tchaptchet S, Kirberg J, Freudenberg N, Schamel W, Galanos C, Freudenberg M. Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes. Eur J Immunol. 2010;40:2506-16 pubmed publisher
    b>Propionibacterium acnes is a human commensal but also an opportunistic pathogen. In mice, P. acnes exerts strong immunomodulatory activities, including formation of intrahepatic granulomas and induction of LPS hypersensitivity...
  3. Mak T, Fischer N, Laube B, Brinkmann V, Metruccio M, Sfanos K, et al. Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation. Cell Microbiol. 2012;14:1720-33 pubmed publisher
    The contribution of the human microbiota to health and disease is poorly understood. Propionibacterium acnes is a prominent member of the skin microbiota, but is also associated with acne vulgaris...
  4. Bemer P, Corvec S, Tariel S, Asseray N, Boutoille D, Langlois C, et al. Significance of Propionibacterium acnes-positive samples in spinal instrumentation. Spine (Phila Pa 1976). 2008;33:E971-6 pubmed publisher
    A retrospective study about Propionibacterium acnes infections after Cotrel-Dubousset (CD) instrumentation. To analyze the significance of P. acnes-positive deep samples after CD. The diagnosis of spinal infections to P...
  5. Yang D, Pornpattananangkul D, Nakatsuji T, Chan M, Carson D, Huang C, et al. The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. Biomaterials. 2009;30:6035-40 pubmed publisher
    This study evaluated the antimicrobial activity of lauric acid (LA) and its liposomal derivatives against Propionibacterium acnes (P. acnes), the bacterium that promotes inflammatory acne...
  6. Dai T, Gupta A, Murray C, Vrahas M, Tegos G, Hamblin M. Blue light for infectious diseases: Propionibacterium acnes, Helicobacter pylori, and beyond?. Drug Resist Updat. 2012;15:223-36 pubmed publisher
    ..Blue light therapy is a clinically accepted approach for Propionibacterium acnes infections...
  7. Miura Y, Ishige I, Soejima N, Suzuki Y, Uchida K, Kawana S, et al. Quantitative PCR of Propionibacterium acnes DNA in samples aspirated from sebaceous follicles on the normal skin of subjects with or without acne. J Med Dent Sci. 2010;57:65-74 pubmed
    To elucidate whether people with hair follicles containing many Propionibacterium acnes cells are prone to acne, we developed a novel method to count the number of P. acnes in hair follicles...
  8. Sampedro M, Huddleston P, Piper K, Karau M, Dekutoski M, Yaszemski M, et al. A biofilm approach to detect bacteria on removed spinal implants. Spine (Phila Pa 1976). 2010;35:1218-24 pubmed publisher
    ..In addition, we compared detection of Staphylococcus and Propionibacterium acnes by rapid cycle real-time polymerase chain reaction with culture of sonicate fluid...
  9. Saleh K, Sonesson A, Persson B, Riesbeck K, Schmidtchen A. A descriptive study of bacterial load of full-thickness surgical wounds in dermatologic surgery. Dermatol Surg. 2011;37:1014-22 pubmed publisher
    ..Coagulase-negative staphylococci and Propionibacterium acnes were the predominant bacteria isolated at all times. Intraoperative analysis was not predictive of SSIs...
  10. Tzellos T, Zampeli V, Makrantonaki E, Zouboulis C. Treating acne with antibiotic-resistant bacterial colonization. Expert Opin Pharmacother. 2011;12:1233-47 pubmed publisher
    Acne is a chronic skin disorder of the pilosebaceous unit; it has a multifactorial pathogenesis. Propionibacterium acnes within the follicle is considered to be a triggering factor of inflammation in acne...
  11. Shinohara D, Vaghasia A, Yu S, Mak T, Bruggemann H, Nelson W, et al. A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes. Prostate. 2013;73:1007-15 pubmed publisher
    ..bacteria-induced chronic inflammation of the prostate using a human prostatectomy-derived strain of Propionibacterium acnes. C57BL/6J mice were inoculated, via urethral catheterization, with vehicle control or a prostatectomy-..
  12. Arnell K, Cesarini K, Lagerqvist Widh A, Wester T, Sjölin J. Cerebrospinal fluid shunt infections in children over a 13-year period: anaerobic cultures and comparison of clinical signs of infection with Propionibacterium acnes and with other bacteria. J Neurosurg Pediatr. 2008;1:366-72 pubmed publisher
    ..performed in addition to the usual tests, to prolonged incubation times, and to infections caused by Propionibacterium acnes. The medical records of 237 hydrocephalic children (age range 0-15 years) in whom operations were ..
  13. Shibata M, Katsuyama M, Onodera T, Ehama R, Hosoi J, Tagami H. Glucocorticoids enhance Toll-like receptor 2 expression in human keratinocytes stimulated with Propionibacterium acnes or proinflammatory cytokines. J Invest Dermatol. 2009;129:375-82 pubmed publisher
    ..In acne vulgaris, TLR2 activation by Propionibacterium acnes (P...
  14. McDowell A, Nagy I, Magyari M, Barnard E, Patrick S. The opportunistic pathogen Propionibacterium acnes: insights into typing, human disease, clonal diversification and CAMP factor evolution. PLoS ONE. 2013;8:e70897 pubmed publisher
    ..These evolutionary insights may prove important for discussions surrounding camp2 as an immunotherapy target for acne, and the effect such treatments may have on commensal lineages. ..
  15. Störmer M, Kleesiek K, Dreier J. Propionibacterium acnes lacks the capability to proliferate in platelet concentrates. Vox Sang. 2008;94:193-201 pubmed
    b>Propionibacterium acnes is considered to be one of the most frequent contaminants of platelet concentrates (PCs) when anaerobic culture-based detection methods are used...
  16. Iinuma K, Sato T, Akimoto N, Noguchi N, Sasatsu M, Nishijima S, et al. Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. J Invest Dermatol. 2009;129:2113-9 pubmed publisher
    b>Propionibacterium acnes is considered to be involved in the aggravation of acne vulgaris, but it remains unclear whether P. acnes directly influences lipogenesis in sebaceous glands. In this study, we showed that a culture medium of P...
  17. Lee S, Kim J, Jeong S, Jeon J, Yoon H, Jeong M, et al. Protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to Propionibacterium acnes. Arch Dermatol Res. 2010;302:745-56 pubmed publisher
    b>Propionibacterium acnes (P. acnes) has been known to produce various exogenous proteases, however, their role in acne pathogenesis remains largely unknown...
  18. Sato T, Kurihara H, Akimoto N, Noguchi N, Sasatsu M, Ito A. Augmentation of gene expression and production of promatrix metalloproteinase 2 by Propionibacterium acnes-derived factors in hamster sebocytes and dermal fibroblasts: a possible mechanism for acne scarring. Biol Pharm Bull. 2011;34:295-9 pubmed
    ..To investigate the involvement of Propionibacterium acnes (P...
  19. Lomholt H, Kilian M. [Is acne caused by colonization with the "wrong" strain of Propionibacterium acnes? A review of the role of Propionibacterium acnes in acne]. Ugeskr Laeger. 2008;170:1234-7 pubmed
    ..A number of studies suggest that the species Propionibacterium acnes plays an important role in the pathogenesis, and new data point towards molecular mechanisms by which the ..
  20. Sfanos K, Isaacs W. An evaluation of PCR primer sets used for detection of Propionibacterium acnes in prostate tissue samples. Prostate. 2008;68:1492-5 pubmed publisher
    Multiple studies have now shown that Propionibacterium acnes can be cultured from post-prostatectomy derived prostate tissue samples. In contrast, both universal eubacterial 16S rDNA PCR and P...
  21. Tomida S, Nguyen L, Chiu B, Liu J, Sodergren E, Weinstock G, et al. Pan-genome and comparative genome analyses of propionibacterium acnes reveal its genomic diversity in the healthy and diseased human skin microbiome. MBio. 2013;4:e00003-13 pubmed publisher
    b>Propionibacterium acnes constitutes a major part of the skin microbiome and contributes to human health...
  22. Jalian H, Liu P, Kanchanapoomi M, Phan J, Legaspi A, Kim J. All-trans retinoic acid shifts Propionibacterium acnes-induced matrix degradation expression profile toward matrix preservation in human monocytes. J Invest Dermatol. 2008;128:2777-82 pubmed publisher
    b>Propionibacterium acnes is a critical component in the pathogenesis of acne vulgaris, stimulating the production of various inflammatory mediators, such as cytokines and chemokines, important in the local inflammatory response found in ..
  23. List R, Sheikh N, Theologou T, Mitchell I, Mathew T. Propionibacterium acnes endocarditis of a prosthetic aortic valve. Clin Cardiol. 2009;32:E46-7 pubmed publisher
    ..We report a case of P. acnes infective endocarditis identified on prolonged blood cultures with aortic root abscess involving a Starr-Edwards valve. Intravenous antibiotics and valve replacement led to recovery. ..
  24. Alexeyev O, Marklund I, Shannon B, Golovleva I, Olsson J, Andersson C, et al. Direct visualization of Propionibacterium acnes in prostate tissue by multicolor fluorescent in situ hybridization assay. J Clin Microbiol. 2007;45:3721-8 pubmed
    ..BPH) frequently contain histological inflammation, and a proportion of these patients show evidence of Propionibacterium acnes infection in the prostate gland...
  25. Choi C, Choi J, Park K, Youn S. Ultraviolet-induced red fluorescence of patients with acne reflects regional casual sebum level and acne lesion distribution: qualitative and quantitative analyses of facial fluorescence. Br J Dermatol. 2012;166:59-66 pubmed publisher
    The ultraviolet (UV)-induced red fluorescence of patients with acne has been considered to be caused by Propionibacterium acnes.
  26. He R, Yao X, Yao N, Wang M, Dai Y, Gao H, et al. Protective effects of radix Rosa laevigata against Propionibacterium acnes and lipopolysaccharide-induced liver injury. Biosci Biotechnol Biochem. 2009;73:1129-36 pubmed
    We investigated the effects of an extract of Radix Rosa laevigata (R. R. laevigata) on Propionibacterium acnes (P. acnes) and lipopolysaccharide (LPS)-induced acute liver injury...
  27. Yang H, Guo H, Fan K, Zhang B, Zhao L, Hou S, et al. Clearance of Propionibacterium acnes by kupffer cells is regulated by osteopontin through modulating the expression of p47phox. Mol Immunol. 2011;48:2019-26 pubmed publisher
    ..In this report, we revealed that OPN could affect the clearance of Propionibacterium acnes in kupffer cells. In a murine model of P...
  28. Patil V, Bandivadekar A, Debjani D. Inhibition of Propionibacterium acnes lipase by extracts of Indian medicinal plants. Int J Cosmet Sci. 2012;34:234-9 pubmed publisher
    ..The aim of this study was to identify inhibitory effects of plant extracts on the lipase activity of Propionibacterium acnes. Colorimetric microassay was used to determine lipase activity...
  29. Lee D, Yamasaki K, Rudsil J, Zouboulis C, Park G, Yang J, et al. Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes. J Invest Dermatol. 2008;128:1863-6 pubmed publisher
  30. Xiao Y, Xu J, Mao C, Jin M, Wu Q, Zou J, et al. 18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha. J Biol Chem. 2010;285:1128-37 pubmed publisher
    ..Here, we investigate the effect of GA in Propionibacterium acnes-induced acute inflammatory liver injury. C57BL/6 mice were primed with P...
  31. Kilian M, Scholz C, Lomholt H. Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnes. J Clin Microbiol. 2012;50:1158-65 pubmed publisher
    b>Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris, in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals...
  32. Tchaptchet S, Gumenscheimer M, Kalis C, Freudenberg N, Holscher C, Kirschning C, et al. TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes. PLoS ONE. 2012;7:e39155 pubmed publisher
    b>Propionibacterium acnes is usually a relatively harmless commensal. However, under certain, poorly understood conditions it is implicated in the etiology of specific inflammatory diseases. In mice, P...
  33. Nakatsuji T, Kao M, Fang J, Zouboulis C, Zhang L, Gallo R, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009;129:2480-8 pubmed publisher
    ..not been demonstrated whether lauric acid can be used for acne treatment as a natural antibiotic against Propionibacterium acnes (P. acnes), which promotes follicular inflammation (inflammatory acne)...
  34. Kinney M, Yentzer B, Fleischer A, Feldman S. Trends in the treatment of acne vulgaris: are measures being taken to avoid antimicrobial resistance?. J Drugs Dermatol. 2010;9:519-24 pubmed
    ..Antibiotic-resistance of Propionibacterium acnes (P...
  35. Wang Y, Zhang Z, Chen L, Guang H, Li Z, Yang H, et al. Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris. PLoS ONE. 2011;6:e22120 pubmed publisher
    ..In this study, cathelicidin-BF was found exerting strong antibacterial activities against Propionibacterium acnes. Its minimal inhibitory concentration against two strains of P. acnes was 4.7 µg/ml...
  36. Nakatsuji T, Liu Y, Huang C, Zoubouis C, Gallo R, Huang C. Antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the IL-8 production in human sebocytes: relevance to therapy for acne vulgaris. J Invest Dermatol. 2008;128:2451-7 pubmed publisher
    b>Propionibacterium acnes is a key pathogen involved in the progression of inflammation in acne vulgaris. We examined whether vaccination against P. acnes suppressed P. acnes-induced skin inflammation. Inactivation of P...
  37. Furukawa A, Uchida K, Ishige Y, Ishige I, Kobayashi I, Takemura T, et al. Characterization of Propionibacterium acnes isolates from sarcoid and non-sarcoid tissues with special reference to cell invasiveness, serotype, and trigger factor gene polymorphism. Microb Pathog. 2009;46:80-7 pubmed publisher
    Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism so far isolated from sarcoid lesions. To examine whether P...
  38. Holmberg A, Lood R, Morgelin M, Soderquist B, Holst E, Collin M, et al. Biofilm formation by Propionibacterium acnes is a characteristic of invasive isolates. Clin Microbiol Infect. 2009;15:787-95 pubmed publisher
    b>Propionibacterium acnes is a common and probably underestimated cause of delayed joint prosthesis infection. Bacterial biofilm formation is central in the pathogenesis of infections related to foreign material, and P...
  39. Wu L, Zhao M, Xia C, Ni H, Zhang H. [Isolation, identification and rumen fermentation characteristics of Propionibacterium acnes]. Wei Sheng Wu Xue Bao. 2009;49:168-73 pubmed
    ..We isolated and screened a Propionibacterium acnes strain from health cow rumen fluid, and studied its rumen fermentation characteristics...
  40. McDowell A, Barnard E, Nagy I, Gao A, Tomida S, Li H, et al. An expanded multilocus sequence typing scheme for propionibacterium acnes: investigation of 'pathogenic', 'commensal' and antibiotic resistant strains. PLoS ONE. 2012;7:e41480 pubmed publisher
    The Gram-positive bacterium Propionibacterium acnes is a member of the normal human skin microbiota and is associated with various infections and clinical conditions...
  41. Qin M, Pirouz A, Kim M, Krutzik S, Garban H, Kim J. Propionibacterium acnes Induces IL-1? secretion via the NLRP3 inflammasome in human monocytes. J Invest Dermatol. 2014;134:381-388 pubmed publisher
    b>Propionibacterium acnes induction of inflammatory responses is a major etiological factor contributing to the pathogenesis of acne vulgaris...
  42. Joo S, Jang S, Kim S, Choi J, Hwang K, Lee D. Anti-acne activity of Selaginella involvens extract and its non-antibiotic antimicrobial potential on Propionibacterium acnes. Phytother Res. 2008;22:335-9 pubmed
    ..Although there has been much debate about the direct involvement of bacteria, Propionibacterium acnes is now believed to contribute to the inflammatory stages of the condition, and thus initiate the inflamed ..
  43. Lood R, Morgelin M, Holmberg A, Rasmussen M, Collin M. Inducible Siphoviruses in superficial and deep tissue isolates of Propionibacterium acnes. BMC Microbiol. 2008;8:139 pubmed publisher
    b>Propionibacterium acnes is a commensal of human skin but is also known to be involved in certain diseases, such as acne vulgaris and infections of orthopaedic implants...
  44. Patel A, Calfee R, Plante M, Fischer S, Green A. Propionibacterium acnes colonization of the human shoulder. J Shoulder Elbow Surg. 2009;18:897-902 pubmed publisher
    b>Propionibacterium acnes (P. acnes) is frequently cultured in patients with wound infections after shoulder surgery. The purpose of this study was to characterize the colonization of various anatomic locations with P...
  45. Olsson J, Drott J, Laurantzon L, Laurantzon O, Bergh A, Elgh F. Chronic prostatic infection and inflammation by Propionibacterium acnes in a rat prostate infection model. PLoS ONE. 2012;7:e51434 pubmed publisher
    ..Several studies have demonstrated the gram-positive bacterium Propionibacterium acnes to be frequently present in prostate tissue from men suffering from prostate disease. P...
  46. Paillot R. A systematic review of the immune-modulators Parapoxvirus ovis and Propionibacterium acnes for the prevention of respiratory disease and other infections in the horse. Vet Immunol Immunopathol. 2013;153:1-9 pubmed publisher
    Inactivated Parapoxvirus ovis (iPPVO) and Propionibacterium acnes (P...
  47. Squaiella C, Longhini A, Braga E, Mussalem J, Ananias R, Yendo T, et al. Modulation of the type I hypersensitivity late phase reaction to OVA by Propionibacterium acnes-soluble polysaccharide. Immunol Lett. 2008;121:157-66 pubmed publisher
    ..Recently, we verified that killed Propionibacterium acnes (P...
  48. Niazi S, Clarke D, Do T, Gilbert S, Mannocci F, Beighton D. Propionibacterium acnes and Staphylococcus epidermidis isolated from refractory endodontic lesions are opportunistic pathogens. J Clin Microbiol. 2010;48:3859-69 pubmed publisher
    ..from 20 refractory endodontic lesions (9 with abscesses and 11 without abscesses) were determined, and Propionibacterium acnes and Staphylococcus epidermidis were among the most predominant organisms...
  49. S rensen M, Mak T, Hurwitz R, Ogilvie L, Mollenkopf H, Meyer T, et al. Mutagenesis of Propionibacterium acnes and analysis of two CAMP factor knock-out mutants. J Microbiol Methods. 2010;83:211-6 pubmed publisher
    ..acnes. The here presented insertional mutagenesis approach will facilitate future studies on P. acnes...
  50. Liu P, Nakatsuji T, Zhu W, Gallo R, Huang C. Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris. Vaccine. 2011;29:3230-8 pubmed publisher
    b>Propionibacterium acnes (P. acnes) bacteria play a key role in the pathogenesis of acne vulgaris...
  51. Coenye T, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B, et al. Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds. Phytomedicine. 2012;19:409-12 pubmed publisher
    b>Propionibacterium acnes is a Gram-positive bacterium that plays an important role in the pathogenesis of acne vulgaris...
  52. Achermann Y, Vogt M, Leunig M, Wüst J, Trampuz A. Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants. J Clin Microbiol. 2010;48:1208-14 pubmed publisher
    ..The pathogen was detected in 5 cases in sonication fluid only (Propionibacterium acnes in all cases; none of these patients had previously received antibiotics) and in 11 cases by multiplex ..
  53. Kumar A, Agarwal S, Ahuja A, Ali J, Choudhry R, Baboota S. Preparation, characterization, and in vitro antimicrobial assessment of nanocarrier based formulation of nadifloxacin for acne treatment. Pharmazie. 2011;66:111-4 pubmed
    ..based formulation of nadifloxacin and to investigate its in vitro antimicrobial effect against Propionibacterium acnes. Nanocarrier based microemulsion formulations were prepared by aqueous titration method, using oleic acid ..
  54. Butler Wu S, Burns E, POTTINGER P, Magaret A, Rakeman J, Matsen F, et al. Optimization of periprosthetic culture for diagnosis of Propionibacterium acnes prosthetic joint infection. J Clin Microbiol. 2011;49:2490-5 pubmed publisher
    b>Propionibacterium acnes is increasingly recognized as an important agent of prosthetic joint infection (PJI). However, the optimum culture conditions for recovery of this organism from PJI specimens have not been determined...
  55. Kamei Y, Sueyoshi M, Hayashi K, Terada R, Nozaki H. The novel anti-Propionibacterium acnes compound, Sargafuran, found in the marine brown alga Sargassum macrocarpum. J Antibiot (Tokyo). 2009;62:259-63 pubmed publisher
    ..of 342 species of marine algae collected from Japanese coastlines for antibacterial activity against Propionibacterium acnes, and found a novel antibacterial compound, which we named Sargafuran, from the MeOH extract of the marine ..
  56. Pannu J, McCarthy A, Martin A, Hamouda T, Ciotti S, Ma L, et al. In vitro antibacterial activity of NB-003 against Propionibacterium acnes. Antimicrob Agents Chemother. 2011;55:4211-7 pubmed publisher
    ..In vitro susceptibility of Propionibacterium acnes to NB-003 formulations and comparator drugs was evaluated...
  57. Sahdo B, Särndahl E, Elgh F, Söderquist B. Propionibacterium acnes activates caspase-1 in human neutrophils. APMIS. 2013;121:652-63 pubmed publisher
    b>Propionibacterium acnes is a Gram-positive, slow-growing, anaerobic bacillus, predominantly found as a commensal on the skin and mucous membranes of adults...
  58. Nagy E, Urban E, Becker S, Kostrzewa M, Vörös A, Hunyadkürti J, et al. MALDI-TOF MS fingerprinting facilitates rapid discrimination of phylotypes I, II and III of Propionibacterium acnes. Anaerobe. 2013;20:20-6 pubmed publisher
    ..b>Propionibacterium acnes is frequently referred to as an anaerobic skin commensal of relatively low pathogenicity...
  59. Kistowska M, Gehrke S, Jankovic D, Kerl K, Fettelschoss A, Feldmeyer L, et al. IL-1? drives inflammatory responses to propionibacterium acnes in vitro and in vivo. J Invest Dermatol. 2014;134:677-685 pubmed publisher
    ..a severe skin disease associated with colonization of the pilo-sebaceous unit by the commensal bacterium Propionibacterium acnes and inflammation. P...
  60. Nakatsuji T, Liu Y, Huang C, Zouboulis C, Gallo R, Huang C. Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris. PLoS ONE. 2008;3:e1551 pubmed publisher
    ..people in the United State and the severity of this disorder is associated with the immune response to Propionibacterium acnes (P. acnes). Systemic therapies for acne target P...
  61. Agarwal V, Golish S, Alamin T. Bacteriologic culture of excised intervertebral disc from immunocompetent patients undergoing single level primary lumbar microdiscectomy. J Spinal Disord Tech. 2011;24:397-400 pubmed publisher
    ..Cultures were positive in 10 patients (19.2%). Propionibacterium acnes was the sole organism isolated in 7 (13...
  62. Brzuszkiewicz E, Weiner J, Wollherr A, Thürmer A, Hüpeden J, Lomholt H, et al. Comparative genomics and transcriptomics of Propionibacterium acnes. PLoS ONE. 2011;6:e21581 pubmed publisher
    The anaerobic gram-positive bacterium Propionibacterium acnes is a human skin commensal that is occasionally associated with inflammatory diseases. Recent work has indicated that evolutionary distinct lineages of P...
  63. Choi J, Bae H, Kim S, Choi I. In vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, Propionibacterium acnes. J Environ Biol. 2011;32:313-8 pubmed
    ..Methanol extracts of 13 species (22.8%) showed inhibitory effects against Propionibacterium acnes. The aqueous extracts of only two species (3.5%) showed antimicrobial activity...
  64. Furustrand Tafin U, Corvec S, Betrisey B, Zimmerli W, Trampuz A. Role of rifampin against Propionibacterium acnes biofilm in vitro and in an experimental foreign-body infection model. Antimicrob Agents Chemother. 2012;56:1885-91 pubmed publisher
    b>Propionibacterium acnes is an important cause of orthopedic-implant-associated infections, for which the optimal treatment has not yet been determined...
  65. Choi J, Piao M, Lee J, Oh J, Kim I, Lee S. Propionibacterium acnes stimulates pro-matrix metalloproteinase-2 expression through tumor necrosis factor-alpha in human dermal fibroblasts. J Invest Dermatol. 2008;128:846-54 pubmed
    b>Propionibacterium acnes (P. acnes) is a commensal microorganism found in sebum-rich skin and plays a role in acne inflammation by stimulating keratinocyte to produce a number of proinflammatory cytokines. However, the role of P...
  66. Nakatsuji T, Shi Y, Zhu W, Huang C, Chen Y, Lee D, et al. Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo. Proteomics. 2008;8:3406-15 pubmed publisher
    ..Unlike humans, most animals produce little or no triglycerides in hair follicles to harbor Propionibacterium acnes a fact that has encumbered the development of novel treatments for acne lesions...
  67. Grange P, Weill B, Dupin N, Batteux F. Does inflammatory acne result from imbalance in the keratinocyte innate immune response?. Microbes Infect. 2010;12:1085-90 pubmed publisher
    ..The pathogenesis of acne involves inflammatory reactions and colonization by the Propionibacterium acnes (P. acnes) strain. P...
  68. Perry A, Lambert P. Propionibacterium acnes: infection beyond the skin. Expert Rev Anti Infect Ther. 2011;9:1149-56 pubmed publisher
    b>Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P...
  69. Moon S, Roh H, Kim Y, Kim J, Ko J, Ro Y. Antibiotic resistance of microbial strains isolated from Korean acne patients. J Dermatol. 2012;39:833-7 pubmed publisher
    ..Among the bacteria isolated, Staphylococcus epidermidis (36 patients) was the most common, followed by Propionibacterium acnes (30 patients). Eleven strains of P. acnes (36.7%) and 25 strains of S. epidermidis (69...
  70. Olsson J, Davidsson S, Unemo M, Mölling P, Andersson S, Andrén O, et al. Antibiotic susceptibility in prostate-derived Propionibacterium acnes isolates. APMIS. 2012;120:778-85 pubmed publisher
    The aim of this study was to determine antibiotic susceptibility of Propionibacterium acnes isolates from prostate. Prostate-derived P...
  71. Zouboulis C. Propionibacterium acnes and sebaceous lipogenesis: a love-hate relationship?. J Invest Dermatol. 2009;129:2093-6 pubmed publisher
    In this issue, Iinuma et al. show that Propionibacterium acnes (P. acnes)-conditioned medium and formalin-killed P. acnes augment intracellular lipid formation in hamster sebocytes by increasing the de novo synthesis of triacylglycerols...
  72. Bellew S, Thiboutot D, Del Rosso J. Pathogenesis of acne vulgaris: what's new, what's interesting and what may be clinically relevant. J Drugs Dermatol. 2011;10:582-5 pubmed
    ..acnes, TLR involvement and role of the sebaceous gland and factors influencing sebum production...
  73. Horvath B, Hunyadkürti J, Vörös A, Fekete C, Urban E, Kemeny L, et al. Genome sequence of Propionibacterium acnes type II strain ATCC 11828. J Bacteriol. 2012;194:202-3 pubmed publisher
    b>Propionibacterium acnes is an anaerobic Gram-positive bacterium that forms part of the normal human cutaneous microbiota and is occasionally associated with inflammatory diseases (I. Kurokawa et al., Exp. Dermatol. 18:821-832, 2009)...
  74. Kang M, Oh J, Lee S, Lim H, Choi N, Kim S. Effect of Lactobacillus reuteri on the proliferation of Propionibacterium acnes and Staphylococcus epidermidis. J Microbiol. 2012;50:137-42 pubmed publisher
    While it is generally accepted that Propionibacterium acnes is involved in the development of acne, other bacteria including Staphylococcus epidermidis have also been isolated from the acne lesion...
  75. McDowell A, Hunyadkürti J, Horvath B, Vörös A, Barnard E, Patrick S, et al. Draft genome sequence of an antibiotic-resistant Propionibacterium acnes strain, PRP-38, from the novel type IC cluster. J Bacteriol. 2012;194:3260-1 pubmed publisher
    b>Propionibacterium acnes, a non-spore-forming, anaerobic gram-positive bacterium, is most notably recognized for its association with acne vulgaris (I. Kurokawa et al., Exp. Dermatol. 18:821-832, 2009)...
  76. Furusawa H, Suzuki Y, Miyazaki Y, Inase N, Eishi Y. Th1 and Th17 immune responses to viable Propionibacterium acnes in patients with sarcoidosis. Respir Investig. 2012;50:104-9 pubmed publisher
    b>Propionibacterium acnes and Mycobacterium tuberculosis have emerged as probable candidates responsible for sarcoidosis...
  77. Albert H, Lambert P, Rollason J, Sorensen J, Worthington T, Pedersen M, et al. Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae?. Eur Spine J. 2013;22:690-6 pubmed publisher
    ..herniated discs have demonstrated the presence of low virulent anaerobic microorganisms, predominantly Propionibacterium acnes, in 7-53 % of patients...
  78. Shu M, Wang Y, Yu J, Kuo S, Coda A, Jiang Y, et al. Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus. PLoS ONE. 2013;8:e55380 pubmed publisher
    ..Here, we demonstrate that fermentation of glycerol with Propionibacterium acnes (P...
  79. Eishi Y. Etiologic aspect of sarcoidosis as an allergic endogenous infection caused by Propionibacterium acnes. Biomed Res Int. 2013;2013:935289 pubmed publisher
    Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism that has been isolated from sarcoid lesions. Many P...
  80. Malinka W, Swiatek P, Sliwińska M, Szponar B, Gamian A, Karczmarzyk Z, et al. Synthesis of novel isothiazolopyridines and their in vitro evaluation against Mycobacterium and Propionibacterium acnes. Bioorg Med Chem. 2013;21:5282-91 pubmed publisher
    ..vitro antibacterial assays against Mycobacterium tuberculosis H37Rv, Mycobacterium fortuitum PCM 672 and Propionibacterium acnes PCM 2400. Compound 13a was found to be the most active derivative against M...
  81. Guío L, Sarria C, de las Cuevas C, Gamallo C, Duarte J. Chronic prosthetic valve endocarditis due to Propionibacterium acnes: an unexpected cause of prosthetic valve dysfunction. Rev Esp Cardiol. 2009;62:167-77 pubmed
    To determine the characteristics of Propionibacterium acnes prosthetic valve endocarditis (PAPVE).
  82. Kranick S, Vinnard C, Kolson D. Propionibacterium acnes brain abscess appearing 10 years after neurosurgery. Arch Neurol. 2009;66:793-5 pubmed publisher
    To describe a case of Propionibacterium acnes infection arising 10 years after neurosurgery and to review the literature regarding similar cases and their treatment.
  83. Assmann G, Kueck O, Kirchhoff T, Rosenthal H, Voswinkel J, Pfreundschuh M, et al. Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: an interventional study. Arthritis Res Ther. 2009;11:R140 pubmed publisher
    ..The etiology of SAPHO syndrome is unknown, but an association with infection by semipathogenic bacteria like Propionibacterium acnes has been suggested. We conducted an interventional study of SAPHO patients receiving antibiotics.
  84. Nakatsuji T, Kao M, Zhang L, Zouboulis C, Gallo R, Huang C. Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. J Invest Dermatol. 2010;130:985-94 pubmed publisher
    ..The supernatant of FFA-incubated sebocyte culture showed antimicrobial activity against Propionibacterium acnes, whereas the enhanced antimicrobial activity of human sebocytes was neutralized by anti-hBD-2 IgG...
  85. McDowell A, Gao A, Barnard E, Fink C, Murray P, Dowson C, et al. A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens. Microbiology. 2011;157:1990-2003 pubmed publisher
    ..org/pacnes/) for Propionibacterium acnes based on the analysis of seven core housekeeping genes...
  86. Negi M, Takemura T, Guzman J, Uchida K, Furukawa A, Suzuki Y, et al. Localization of propionibacterium acnes in granulomas supports a possible etiologic link between sarcoidosis and the bacterium. Mod Pathol. 2012;25:1284-97 pubmed publisher
    ..b>Propionibacterium acnes is the only microorganism, however, found in sarcoid lesions by bacterial culture...
  87. Hsu C, Tsai T, Li Y, Wu W, Huang C, Tsai P. Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation. Food Chem. 2012;135:976-84 pubmed publisher
    ..var. abbreviata Ser.) on Propionibacterium acnes-induced inflammation and to identify the bioactive components...
  88. Tsai H, Lee W, Wang P, Cheng K, Chen Y, Shen S. Propionibacterium acnes-induced iNOS and COX-2 protein expression via ROS-dependent NF-?B and AP-1 activation in macrophages. J Dermatol Sci. 2013;69:122-31 pubmed publisher
    b>Propionibacterium acnes (P. acnes), a gram-positive anaerobic bacterium, plays a critical role in the development of inflammatory lesion as a result of cytokines production by keratinocytes and macrophages activation...
  89. Bayston R, Nuradeen B, Ashraf W, Freeman B. Antibiotics for the eradication of Propionibacterium acnes biofilms in surgical infection. J Antimicrob Chemother. 2007;60:1298-301 pubmed
    b>Propionibacterium acnes is increasingly recognized as a cause of delayed infection after spinal instrumentation or shunting for hydrocephalus. Biofilm development by this organism has recently been demonstrated...
  90. Nakajima M, Nishimoto M, Kitaoka M. Characterization of beta-1,3-galactosyl-N-acetylhexosamine phosphorylase from Propionibacterium acnes. Appl Microbiol Biotechnol. 2009;83:109-15 pubmed publisher
    ..phosphorylase (GalHexNAcP) gene (gnpA) were cloned from the genomic DNA of Propionibacterium acnes JCM6425 and P. acnes JCM6473, showing 99.9% and 97...
  91. Sampedro M, Piper K, McDowell A, Patrick S, Mandrekar J, Rouse M, et al. Species of Propionibacterium and Propionibacterium acnes phylotypes associated with orthopedic implants. Diagn Microbiol Infect Dis. 2009;64:138-45 pubmed publisher
    ..a prospective trial to determine the species of Propionibacterium and the phylotype (IA, IB, II, III) of Propionibacterium acnes isolated from the surface of removed orthopedic implants, and we correlated these findings with the ..
  92. Al Ghazzewi F, Tester R. Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitro. Int J Cosmet Sci. 2010;32:139-42 pubmed publisher
    ..of probiotic bacteria and konjac glucomannan hydrolysates (GMH) to inhibit acne-inducing bacterium, Propionibacterium acnes growth was studied in vitro...