mycobacterium marinum

Summary

Summary: A moderate-growing, photochromogenic species found in aquariums, diseased fish, and swimming pools. It is the cause of cutaneous lesions and granulomas (swimming pool granuloma) in humans. (Dorland, 28th ed)

Top Publications

  1. Casal M, Casal M. Multicenter study of incidence of Mycobacterium marinum in humans in Spain. Int J Tuberc Lung Dis. 2001;5:197-9 pubmed
    A retrospective survey was carried out on the epidemiological monitoring of the isolation incidence of Mycobacterium marinum in 21 laboratories, in an attempt to gain an insight into the frequency of its isolation in Spain...
  2. Clay H, Davis J, Beery D, Huttenlocher A, Lyons S, Ramakrishnan L. Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host Microbe. 2007;2:29-39 pubmed
    ..Using the optically transparent and genetically tractable zebrafish embryo-Mycobacterium marinum model of tuberculosis, we have directly examined early infection in the presence and absence of ..
  3. Meijer A, Verbeek F, Salas Vidal E, Corredor Adámez M, Bussman J, van der Sar A, et al. Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection. Mol Immunol. 2005;42:1185-203 pubmed
    The Mycobacterium marinum-zebrafish infection model was used in this study for analysis of a host transcriptome response to mycobacterium infection at the organismal level...
  4. Abuhammad A, Lowe E, Fullam E, Noble M, Garman E, Sim E. Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site. Protein Cell. 2010;1:384-392 pubmed publisher
    ..From the mode of ligand binding, features of the binding pocket can be identified, which point to a novel mechanism for the acetylation reaction that results in a 3-methyltriazolo[3,4-a]phthalazine ring compound as product. ..
  5. Cosma C, Klein K, Kim R, Beery D, Ramakrishnan L. Mycobacterium marinum Erp is a virulence determinant required for cell wall integrity and intracellular survival. Infect Immun. 2006;74:3125-33 pubmed
    ..understand the role of Erp in Mycobacterium pathogenesis, we generated a mutation in the erp homologue of Mycobacterium marinum, a close genetic relative of M. tuberculosis. erp-deficient M...
  6. Robinson N, Kolter T, Wolke M, Rybniker J, Hartmann P, Plum G. Mycobacterial phenolic glycolipid inhibits phagosome maturation and subverts the pro-inflammatory cytokine response. Traffic. 2008;9:1936-47 pubmed publisher
    ..We in this study characterize a glycolipid of Mycobacterium marinum identified through a screen of mutants disabled in inhibiting phagosome maturation to be phenolphthiocerol ..
  7. Prouty M, Correa N, Barker L, Jagadeeswaran P, Klose K. Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis. FEMS Microbiol Lett. 2003;225:177-82 pubmed
    We report here the development of a pathogenesis model utilizing Mycobacterium marinum infection of zebrafish (Danio rerio) for the study of mycobacterial disease...
  8. Alibaud L, Pawelczyk J, Gannoun Zaki L, Singh V, Rombouts Y, Drancourt M, et al. Increased phagocytosis of Mycobacterium marinum mutants defective in lipooligosaccharide production: a structure-activity relationship study. J Biol Chem. 2014;289:215-28 pubmed publisher
    b>Mycobacterium marinum is a waterborne pathogen responsible for tuberculosis-like infections in ectotherms and is an occasional opportunistic human pathogen. In the environment, M...
  9. Aubry A, Jarlier V, Escolano S, Truffot Pernot C, Cambau E. Antibiotic susceptibility pattern of Mycobacterium marinum. Antimicrob Agents Chemother. 2000;44:3133-6 pubmed
    In vitro activities of 17 antibiotics against 53 clinical strains of Mycobacterium marinum, an atypical mycobacterium responsible for cutaneous infections, were determined using the reference agar dilution method...

More Information

Publications127 found, 100 shown here

  1. Wu T, Chiu C, Su L, Chia J, Lee M, Chiang P, et al. Mycobacterium marinum infection in Taiwan. J Microbiol Immunol Infect. 2002;35:42-6 pubmed
    b>Mycobacterium marinum often causes skin infections, tenosynovitis, arthritis, and osteomyelitis, and occasionally results in severe disseminated infections in immunocompromised patients...
  2. Scheps D, Malca S, Hoffmann H, Nestl B, Hauer B. Regioselective ?-hydroxylation of medium-chain n-alkanes and primary alcohols by CYP153 enzymes from Mycobacterium marinum and Polaromonas sp. strain JS666. Org Biomol Chem. 2011;9:6727-33 pubmed publisher
    ..product yields resulting from C(5)-C(12) alkane and alcohol oxidation catalyzed by CYP153A enzymes from Mycobacterium marinum (CYP153A16) and Polaromonas sp. (CYP153A P. sp.)...
  3. Amrami K, Sundaram M, Shin A, Bishop A. Mycobacterium marinum infections of the distal upper extremities: clinical course and imaging findings in two cases with delayed diagnosis. Skeletal Radiol. 2003;32:546-9 pubmed
    b>Mycobacterium marinum infections cause tenosynovitis of the distal upper extremities and develop as a consequence of skin abrasions acquired in contaminated water...
  4. Ren H, Dover L, Islam S, Alexander D, Chen J, Besra G, et al. Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum. Mol Microbiol. 2007;63:1345-59 pubmed
    ..This is an important step in assessing the differential distribution of LOSs among Mycobacterium species and understanding the role of LOSs in mycobacterial virulence. ..
  5. Pang H, Lee J, Puhaindran M, Tan S, Tan A, Yong F. Mycobacterium marinum as a cause of chronic granulomatous tenosynovitis in the hand. J Infect. 2007;54:584-8 pubmed
    b>Mycobacterium marinum is an uncommon cause of chronic granulomatous flexor tenosynovitis and leads to significant morbidity in the hand. This paper aims to review our treatment of this infection and its clinical outcomes.
  6. Hall Stoodley L, Brun O, Polshyna G, Barker L. Mycobacterium marinum biofilm formation reveals cording morphology. FEMS Microbiol Lett. 2006;257:43-9 pubmed
    ..We assayed the NTM bacterium Mycobacterium marinum strain 1218R, a fish outbreak isolate, for biofilm formation on different surfaces over time using three ..
  7. Wu T, Chiu C, Yang C, Leu H, Huang C, Chen Y, et al. Fish tank granuloma caused by Mycobacterium marinum. PLoS ONE. 2012;7:e41296 pubmed publisher
    b>Mycobacterium marinum causes skin and soft tissue, bone and joint, and rare disseminated infections. In this study, we aimed to investigate the relationship between treatment outcome and antimicrobial susceptibility patterns...
  8. Pozos T, Ramakrishnan L, Ramakrishan L. New models for the study of Mycobacterium-host interactions. Curr Opin Immunol. 2004;16:499-505 pubmed
  9. Pag n Ramos E, Song J, McFalone M, Mudd M, Deretic V. Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum. J Bacteriol. 1998;180:4856-64 pubmed
    ..In this work, we characterized the oxyR-ahpC and furA-katG loci in the nontuberculous pathogen Mycobacterium marinum. In contrast to Mycobacterium smegmatis and like Mycobacterium tuberculosis and Mycobacterium leprae, M...
  10. Elass Rochard E, Rombouts Y, Coddeville B, Maes E, Blervaque R, Hot D, et al. Structural determination and Toll-like receptor 2-dependent proinflammatory activity of dimycolyl-diarabino-glycerol from Mycobacterium marinum. J Biol Chem. 2012;287:34432-44 pubmed publisher
    ..study an apolar glycolipid, presumably corresponding to dimycolyl-diarabino-glycerol, was purified from Mycobacterium marinum and subsequently identified as a 5-O-mycolyl-?-Araf-(1?2)-5-O-mycolyl-?-Araf-(1?1')-glycerol (designated ..
  11. Streit M, Böhlen L, Hunziker T, Zimmerli S, Tscharner G, Nievergelt H, et al. Disseminated Mycobacterium marinum infection with extensive cutaneous eruption and bacteremia in an immunocompromised patient. Eur J Dermatol. 2006;16:79-83 pubmed
    b>Mycobacterium marinum can cause fish tank granuloma (or swimming pool or aquarium granuloma) in immunocompetent patients...
  12. Weerdenburg E, Abdallah A, Mitra S, de Punder K, van der Wel N, Bird S, et al. ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish. Cell Microbiol. 2012;14:728-39 pubmed publisher
    ..In this work, we studied the effects of ESX-5 in embryonic and adult zebrafish using Mycobacterium marinum. We found that ESX-5-deficient M. marinum was slightly attenuated in zebrafish embryos...
  13. Tobin D, Roca F, Oh S, McFarland R, Vickery T, Ray J, et al. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 2012;148:434-46 pubmed publisher
    ..In zebrafish, we find that susceptibility to Mycobacterium marinum can result from either inadequate or excessive acute inflammation...
  14. Mehta P, Pandey A, Subbian S, El Etr S, Cirillo S, Samrakandi M, et al. Identification of Mycobacterium marinum macrophage infection mutants. Microb Pathog. 2006;40:139-51 pubmed
    b>Mycobacterium marinum is an important pathogen of humans, amphibians and fish. Most pathogenic mycobacteria, including M. marinum, infect, survive and replicate primarily intracellularly within macrophages...
  15. Schwendiman M, Johnson R, Henning J. Subcutaneous nodules with sporotrichoid spread. Dermatol Online J. 2009;15:11 pubmed
    b>Mycobacterium marinum is an atypical mycobacterium found worldwide and associated with swimming pools and aquariums. Infections typically present with subcutaneous nodules and lymphangitis...
  16. Cosma C, Humbert O, Ramakrishnan L. Superinfecting mycobacteria home to established tuberculous granulomas. Nat Immunol. 2004;5:828-35 pubmed
    ..We show here that superinfecting Mycobacterium marinum traffic rapidly into preexisting granulomas, including their caseous (necrotic) centers, through specific ..
  17. van der Sar A, Abdallah A, Sparrius M, Reinders E, Vandenbroucke Grauls C, Bitter W. Mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence. Infect Immun. 2004;72:6306-12 pubmed
    b>Mycobacterium marinum causes a systemic tuberculosis-like disease in a large number of poikilothermic animals and is used as a model for mycobacterial pathogenesis...
  18. Koo I, Wang C, Raghavan S, Morisaki J, Cox J, Brown E. ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection. Cell Microbiol. 2008;10:1866-78 pubmed publisher
    ..a virulence factor necessary for phagosome escape and host cell lysis by a contact-dependent haemolysin in Mycobacterium marinum. Here we show that ESX-1 from M. marinum and M...
  19. Ucko M, Colorni A, Kvitt H, Diamant A, Zlotkin A, Knibb W. Strain variation in Mycobacterium marinum fish isolates. Appl Environ Microbiol. 2002;68:5281-7 pubmed
    A molecular characterization of two Mycobacterium marinum genes, 16S rRNA and hsp65, was carried out with a total of 21 isolates from various species of fish from both marine and freshwater environments of Israel, Europe, and the Far ..
  20. Abdallah A, Bestebroer J, Savage N, de Punder K, van Zon M, Wilson L, et al. Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation. J Immunol. 2011;187:4744-53 pubmed publisher
    ..proteins secreted by ESX-5 are not required for the translocation of Mycobacterium tuberculosis or Mycobacterium marinum to the cytosol of host cells. However, the M...
  21. Ankomah P, Levin B. Two-drug antimicrobial chemotherapy: a mathematical model and experiments with Mycobacterium marinum. PLoS Pathog. 2012;8:e1002487 pubmed publisher
    ..In this report, mathematical models and in vitro experiments with Mycobacterium marinum and five antimycobacterial drugs are used to quantitatively evaluate the pharmaco-, population and ..
  22. Oh C, Moon C, Choi T, Kim B, Jang J. Mycobacterium marinum infection in Drosophila melanogaster for antimycobacterial activity assessment. J Antimicrob Chemother. 2013;68:601-9 pubmed publisher
    ..are a well-characterized immune system and high degree of susceptibility to tuberculosis caused by Mycobacterium marinum. The D. melanogaster-M...
  23. Tønjum T, Welty D, Jantzen E, Small P. Differentiation of Mycobacterium ulcerans, M. marinum, and M. haemophilum: mapping of their relationships to M. tuberculosis by fatty acid profile analysis, DNA-DNA hybridization, and 16S rRNA gene sequence analysis. J Clin Microbiol. 1998;36:918-25 pubmed
    ..tuberculosis. M. marinum may be particularly useful in this regard since strains of this species grow much more rapidly than M. tuberculosis and yet can cause systemic disease in immunocompromised hosts. ..
  24. Lewis F, Marsh B, von Reyn C. Fish tank exposure and cutaneous infections due to Mycobacterium marinum: tuberculin skin testing, treatment, and prevention. Clin Infect Dis. 2003;37:390-7 pubmed
    In the present study, 8 patients with soft tissue infection due to Mycobacterium marinum are described, and contemporary data on treatment are reviewed...
  25. Smith J, Manoranjan J, Pan M, Bohsali A, Xu J, Liu J, et al. Evidence for pore formation in host cell membranes by ESX-1-secreted ESAT-6 and its role in Mycobacterium marinum escape from the vacuole. Infect Immun. 2008;76:5478-87 pubmed publisher
    ..marinum escape from the vacuole and cell-to-cell spread. Our study provides new insight into the mechanism by which ESX-1 secretion and ESAT-6 enhance the virulence of mycobacterial infection. ..
  26. Cheung J, Fung B, Wong S, Ip W. Review article: Mycobacterium marinum infection of the hand and wrist. J Orthop Surg (Hong Kong). 2010;18:98-103 pubmed
    Misdiagnosis and delayed treatment of Mycobacterium marinum infection is common because of its diverse manifestations...
  27. Sun G, Chen C, Li J, Gui X, Li X, Chen L, et al. Discriminatory potential of a novel set of Variable Number of Tandem Repeats for genotyping Mycobacterium marinum. Vet Microbiol. 2011;152:200-4 pubmed publisher
    b>Mycobacterium marinum is a free-living bacterium that infects fish and amphibians, but is also an opportunistic pathogen in humans...
  28. Chan K, Knaak T, Satkamp L, Humbert O, Falkow S, Ramakrishnan L. Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection. Proc Natl Acad Sci U S A. 2002;99:3920-5 pubmed
    ..We analyzed the gene expression profile of Mycobacterium marinum, the cause of fish and amphibian tuberculosis, during its persistence in granulomas...
  29. Petrini B. Mycobacterium marinum: ubiquitous agent of waterborne granulomatous skin infections. Eur J Clin Microbiol Infect Dis. 2006;25:609-13 pubmed
    b>Mycobacterium marinum is a waterborne mycobacterium that commonly infects fish and amphibians worldwide...
  30. Rallis E, Koumantaki Mathioudaki E. Treatment of Mycobacterium marinum cutaneous infections. Expert Opin Pharmacother. 2007;8:2965-78 pubmed
    b>Mycobacterium marinum is a non-tuberculous mycobacterium found in non-chlorinated water, with worldwide prevalence. It is the most common atypical Mycobacterium that causes opportunistic infection in humans...
  31. Feng Y, Xu H, Wang H, Zhang C, Zong W, Wu Q. Outbreak of a cutaneous Mycobacterium marinum infection in Jiangsu Haian, China. Diagn Microbiol Infect Dis. 2011;71:267-72 pubmed publisher
    b>Mycobacterium marinum is a slow-growing mycobacterium. In November 2008, we diagnosed a patient with M. marinum infection who worked at a fish farm in Jiangsu Haian, China...
  32. Bråbäck M, Riesbeck K, Forsgren A. Susceptibilities of Mycobacterium marinum to gatifloxacin, gemifloxacin, levofloxacin, linezolid, moxifloxacin, telithromycin, and quinupristin-dalfopristin (Synercid) compared to its susceptibilities to reference macrolides and quinolones. Antimicrob Agents Chemother. 2002;46:1114-6 pubmed
    The susceptibility pattern of Mycobacterium marinum was determined. Quinupristin-dalfopristin and telithromycin were less active than clarithromycin. Linezolid showed good antimicrobial activity at clinically achievable concentrations...
  33. Arend S, van Meijgaarden K, de Boer K, de Palou E, van Soolingen D, Ottenhoff T, et al. Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M. kansasii. J Infect Dis. 2002;186:1797-807 pubmed
    ..ELISA and ELISPOT yielded comparable results, as did whole antigen and peptides (P<.0001). These results may be relevant for the development of novel assays for diagnosis of tuberculosis. ..
  34. Ruley K, Ansede J, Pritchett C, Talaat A, Reimschuessel R, Trucksis M. Identification of Mycobacterium marinum virulence genes using signature-tagged mutagenesis and the goldfish model of mycobacterial pathogenesis. FEMS Microbiol Lett. 2004;232:75-81 pubmed
    b>Mycobacterium marinum, a causative agent of fish tuberculosis, is one of the most closely related Mycobacterium species (outside the M. tuberculosis complex) to M. tuberculosis, the etiologic agent of human tuberculosis...
  35. Burguière A, Hitchen P, Dover L, Kremer L, Ridell M, Alexander D, et al. LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum. J Biol Chem. 2005;280:42124-33 pubmed
    ..Previous studies have shown that Mycobacterium marinum produces large amounts of a diacylglycosylphenolphthiocerol, "phenolic" glycolipid...
  36. Kennedy G, Morisaki J, Champion P. Conserved mechanisms of Mycobacterium marinum pathogenesis within the environmental amoeba Acanthamoeba castellanii. Appl Environ Microbiol. 2012;78:2049-52 pubmed publisher
    b>Mycobacterium marinum is a waterborne mycobacterial pathogen. Due to their common niche, protozoa likely represent natural hosts for M. marinum. We demonstrate that the ESX-1 secretion system is required for M...
  37. Wang H, Dong D, Tang S, Chen X, Gao Q. PPE38 of Mycobacterium marinum triggers the cross-talk of multiple pathways involved in the host response, as revealed by subcellular quantitative proteomics. J Proteome Res. 2013;12:2055-66 pubmed publisher
    ..The results of our systems investigation now indicate that there is cross-talk involving a broad range of diverse biological pathways/processes that coordinate the host response to M. marinum PPE38...
  38. Rhomberg P, Jones R. In vitro activity of 11 antimicrobial agents, including gatifloxacin and GAR936, tested against clinical isolates of Mycobacterium marinum. Diagn Microbiol Infect Dis. 2002;42:145-7 pubmed
    ..agents were determined using Etest (AB BIODISK, Solna, Sweden) against 37 clinical isolates of Mycobacterium marinum. The most potent agent (MIC(50,) 0.047 microg/mL) was trimethoprim/sulfamethoxazole, but only 91...
  39. Dionne M, Pham L, Shirasu Hiza M, Schneider D. Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr Biol. 2006;16:1977-85 pubmed
    ..Here, we examine the pathogenesis associated with Mycobacterium marinum infection in the fly. M. marinum is closely related to M...
  40. McLaughlin B, Chon J, MacGurn J, Carlsson F, Cheng T, Cox J, et al. A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. PLoS Pathog. 2007;3:e105 pubmed
    ..Both the Mycobacterium marinum and the Mycobacterium tuberculosis genomes contain an extended region of difference 1 (extRD1) locus that ..
  41. Stamm L, Brown E. Mycobacterium marinum: the generalization and specialization of a pathogenic mycobacterium. Microbes Infect. 2004;6:1418-28 pubmed
    b>Mycobacterium marinum is being used increasingly as a model for understanding pathogenic mycobacteria. However, recently discovered differences between M. marinum and M...
  42. Lai C, Lee L, Chang Y, Lee Y, Ding L, Hsueh P. Pulmonary infection due to Mycobacterium marinum in an immunocompetent patient. Clin Infect Dis. 2005;40:206-8 pubmed
  43. Davis J, Ramakrishnan L. The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell. 2009;136:37-49 pubmed publisher
    ..However, work in zebrafish infected with Mycobacterium marinum suggests that granulomas contribute to early bacterial growth...
  44. Gao L, Pak M, Kish R, Kajihara K, Brown E. A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages. Infect Immun. 2006;74:1757-67 pubmed
    ..We have found a Mycobacterium marinum locus of two genes that is required for both invasion and intracellular survival in macrophages...
  45. Stragier P, Hermans K, Stinear T, Portaels F. First report of a mycolactone-producing Mycobacterium infection in fish agriculture in Belgium. FEMS Microbiol Lett. 2008;286:93-5 pubmed publisher
    In the past few years, a mycolactone-producing subgroup of the Mycobacterium marinum complex has been identified and analyzed. These IS2404-positive species cause pathology in frogs and fish...
  46. Ramos J, García Sepulcre M, Rodriguez J, Padilla S, Gutierrez F. Mycobacterium marinum infection complicated by anti-tumour necrosis factor therapy. J Med Microbiol. 2010;59:617-21 pubmed publisher
    ..We describe sporotrichoid spread of Mycobacterium marinum in a man with Crohn's disease treated with infliximab...
  47. Lerena M, Colombo M. Mycobacterium marinum induces a marked LC3 recruitment to its containing phagosome that depends on a functional ESX-1 secretion system. Cell Microbiol. 2011;13:814-35 pubmed publisher
    ..b>Mycobacterium marinum is the causative agent of the fish-tank granuloma and has been widely used as an alternative model to ..
  48. El Etr S, Yan L, Cirillo J. Fish monocytes as a model for mycobacterial host-pathogen interactions. Infect Immun. 2001;69:7310-7 pubmed
    b>Mycobacterium marinum, a relatively rapid-growing fish and human pathogen, has become an important model for the investigation of mycobacterial pathogenesis. M...
  49. Fortune S, Rubin E. The complex relationship between mycobacteria and macrophages: it's not all bliss. Cell Host Microbe. 2007;2:5-6 pubmed
    ..show in a recent issue of Cell, there are both benefits and drawbacks for the pathogen in adopting this strategy, and some of our fundamental assumptions about how the host cell and bacterium interact might need to be reexamined. ..
  50. Porter J, Tobias N, Hong H, Tuck K, Jenkin G, Stinear T. Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum. Microbiology. 2009;155:1923-33 pubmed publisher
    ..of these two constructs permitted the two-step transfer of the entire 174 kb pMUM001 plasmid to Mycobacterium marinum, a rapidly growing non-mycolactone-producing mycobacterium that is a close genetic relative of M. ulcerans...
  51. Stoop E, Schipper T, Rosendahl Huber S, Nezhinsky A, Verbeek F, Gurcha S, et al. Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component. Dis Model Mech. 2011;4:526-36 pubmed publisher
    ..We exploited the zebrafish embryo Mycobacterium marinum infection model to study initiation of granuloma formation and developed an in vivo screen to select for ..
  52. Solomon J, Leung G, Isberg R. Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin. Infect Immun. 2003;71:3578-86 pubmed
    b>Mycobacterium marinum causes tuberculosis-like disease in fish and amphibians and has been used as a model mycobacterial species because of its rapid growth and less stringent containment requirements relative to other mycobacterial ..
  53. Subbian S, Mehta P, Cirillo S, Bermudez L, Cirillo J. A Mycobacterium marinum mel2 mutant is defective for growth in macrophages that produce reactive oxygen and reactive nitrogen species. Infect Immun. 2007;75:127-34 pubmed
    ..We recently constructed a Mycobacterium marinum mel2 locus mutant, which is known to affect macrophage infection...
  54. Deng W, Tang X, Hou M, Li C, Xie J. New insights into the pathogenesis of tuberculosis revealed by Mycobacterium marinum: the zebrafish model from the systems biology perspective. Crit Rev Eukaryot Gene Expr. 2011;21:337-45 pubmed
    ..This research serves to deepen our understanding of this complex process and to promote the discovery of better countermeasures against tuberculosis. ..
  55. Watral V, Kent M. Pathogenesis of Mycobacterium spp. in zebrafish (Danio rerio) from research facilities. Comp Biochem Physiol C Toxicol Pharmacol. 2007;145:55-60 pubmed
    ..United States: Mycobacterium abscessus, Mycobacterium peregrinum, Mycobacterium chelonae (2 isolates), and Mycobacterium marinum. We also included two isolates of M. marinum from other fishes...
  56. Osorio F, Magina S, Carvalho T, Goncalves M, Azevedo F. Mycobacterium marinum skin infection with tenosynovitis successfully treated with doxycycline. Dermatol Online J. 2010;16:7 pubmed
    Skin infection with Mycobacterium marinum can rarely spread to deeper structures, making it more difficult to treat. We report a case of a M...
  57. Dong D, Wang D, Li M, Wang H, Yu J, Wang C, et al. PPE38 modulates the innate immune response and is required for Mycobacterium marinum virulence. Infect Immun. 2012;80:43-54 pubmed publisher
    ..In this study, we isolated a transposon-inactivated PPE38 mutant of Mycobacterium marinum and characterized its phenotype...
  58. Ramakrishnan L, Federspiel N, Falkow S. Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family. Science. 2000;288:1436-9 pubmed
    ..We identified several genes preferentially expressed when Mycobacterium marinum, the cause of fish and amphibian tuberculosis, resides in host granulomas and/or macrophages...
  59. Hagedorn M, Rohde K, Russell D, Soldati T. Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts. Science. 2009;323:1729-33 pubmed publisher
    ..This insight offers new directions for research into the spreading of tubercular mycobacteria infections in mammalian cells...
  60. Stinear T, Jenkin G, Johnson P, Davies J. Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence. J Bacteriol. 2000;182:6322-30 pubmed
    Previous studies of the 16S rRNA genes from Mycobacterium ulcerans and Mycobacterium marinum have suggested a very close genetic relationship between these species (99.6% identity)...
  61. Chemlal K, Huys G, Laval F, Vincent V, Savage C, Gutierrez C, et al. Characterization of an unusual Mycobacterium: a possible missing link between Mycobacterium marinum and Mycobacterium ulcerans. J Clin Microbiol. 2002;40:2370-80 pubmed
    ..a previous study with a set of temporally and geographically diverse Mycobacterium ulcerans (n = 29) and Mycobacterium marinum (n = 29) isolates (K. Chemlal, G. Huys, P.-A. Fonteyne, V. Vincent, A. G. Lopez, L. Rigouts, J. Swings, W...
  62. Wongworawat M, Holtom P, Learch T, Fedenko A, Stevanovic M. A prolonged case of Mycobacterium marinum flexor tenosynovitis: radiographic and histological correlation, and review of the literature. Skeletal Radiol. 2003;32:542-5 pubmed
    We report on a 30-year-old man with prolonged Mycobacterium marinum flexor tenosynovitis. Due to low clinical suspicion, diagnosis was not made until 8 years after initial presentation...
  63. Song C, Lee J, Kim H, Park J, Paik T, Jo E. Interleukin-8 is differentially expressed by human-derived monocytic cell line U937 infected with Mycobacterium tuberculosis H37Rv and Mycobacterium marinum. Infect Immun. 2003;71:5480-7 pubmed
    Although Mycobacterium marinum is closely related to Mycobacterium tuberculosis H37Rv genomically, the clinical outcome in humans is quite different for M. marinum and M. tuberculosis infections...
  64. Cummins D, Delacerda D, Tausk F. Mycobacterium marinum with different responses to second-generation tetracyclines. Int J Dermatol. 2005;44:518-20 pubmed
    Persistent cutaneous infections with Mycobacterium marinum can follow exposure of injured skin to contaminated water or fish, and can be treated with second-generation tetracyclines in addition to other antimicrobials...
  65. Hagedorn M, Soldati T. Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection. Cell Microbiol. 2007;9:2716-33 pubmed publisher
    b>Mycobacterium marinum, a close relative of Mycobacterium tuberculosis, provides a useful model to study the pathogenesis of tuberculosis in genetically tractable model organisms...
  66. Clay H, Volkman H, Ramakrishnan L. Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. Immunity. 2008;29:283-94 pubmed publisher
    ..We monitored transparent Mycobacterium marinum-infected zebrafish live to conduct a stepwise dissection of how TNF signaling operates in mycobacterial ..
  67. Alibaud L, Rombouts Y, Trivelli X, Burguière A, Cirillo S, Cirillo J, et al. A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos. Mol Microbiol. 2011;80:919-34 pubmed publisher
    Infection of the zebrafish with Mycobacterium marinum is regarded as a well-established experimental model to study the pathogenicity of Mycobacterium tuberculosis. Herein, a M...
  68. Li Y, Champion M, Sun L, Champion P, Wojcik R, Dovichi N. Capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry as an alternative proteomics platform to ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry for samples of intermediate complexity. Anal Chem. 2012;84:1617-22 pubmed publisher
    ..of a tryptic digest of a sample of intermediate protein complexity, the secreted protein fraction of Mycobacterium marinum. For electrophoretic analysis, 11 fractions were generated from the sample using reverse-phase liquid ..
  69. Gao L, Groger R, Cox J, Beverley S, Lawson E, Brown E. Transposon mutagenesis of Mycobacterium marinum identifies a locus linking pigmentation and intracellular survival. Infect Immun. 2003;71:922-9 pubmed
    ..b>Mycobacterium marinum has recently been used as a model for aspects of the pathogenesis of tuberculosis because of its close ..
  70. Ucko M, Colorni A. Mycobacterium marinum infections in fish and humans in Israel. J Clin Microbiol. 2005;43:892-5 pubmed
    Israeli Mycobacterium marinum isolates from humans and fish were compared by direct sequencing of the 16S rRNA and hsp65 genes, restriction mapping, and amplified fragment length polymorphism analysis...
  71. van der Sar A, Spaink H, Zakrzewska A, Bitter W, Meijer A. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. Mol Immunol. 2009;46:2317-32 pubmed publisher
    ..outcomes: an acute disease with early lethality or a chronic disease with granuloma formation, caused by Mycobacterium marinum strains Mma20 and E11, respectively...
  72. van der Woude A, Sarkar D, Bhatt A, Sparrius M, Raadsen S, Boon L, et al. Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum. J Biol Chem. 2012;287:20417-29 pubmed publisher
    ..study, we set out to identify novel components involved in the secretion of PE_PGRS proteins by screening Mycobacterium marinum transposon mutants for secretion defects...
  73. Kurokawa S, Kabayama J, Hwang S, Nho S, Hikima J, Jung T, et al. Comparative genome analysis of fish and human isolates of Mycobacterium marinum. Mar Biotechnol (NY). 2013;15:596-605 pubmed publisher
    b>Mycobacterium marinum is a major causative agent of mycobacteriosis in fish that has a broad range of hosts, including in human isolates. So far, genomic analyses have focused on the human isolate...
  74. Aubry A, Chosidow O, Caumes E, Robert J, Cambau E. Sixty-three cases of Mycobacterium marinum infection: clinical features, treatment, and antibiotic susceptibility of causative isolates. Arch Intern Med. 2002;162:1746-52 pubmed
    b>Mycobacterium marinum is a nontuberculous mycobacterium responsible for skin infections. Although cases have been seldom reported, no series of M marinum infection has been recently reported and the treatment is not standardized.
  75. Cosma C, Sherman D, Ramakrishnan L. The secret lives of the pathogenic mycobacteria. Annu Rev Microbiol. 2003;57:641-76 pubmed
    ..In addition, we highlight current controversies and unanswered questions in these areas...
  76. Lee E, Rubin D, Brown D. Recurrent Mycobacterium marinum tenosynovitis of the wrist mimicking extraarticular synovial chondromatosis on MR images. Skeletal Radiol. 2004;33:405-8 pubmed
    ..We report a case of recurrent M. marinum infection involving the flexor tendons within the carpal tunnel in which the rice bodies were mistaken for synovial chondromatosis on MR images...
  77. Kent M, Watral V, Wu M, Bermudez L. In vivo and in vitro growth of Mycobacterium marinum at homoeothermic temperatures. FEMS Microbiol Lett. 2006;257:69-75 pubmed
    b>Mycobacterium marinum can cause systemic infection in fishes and skin infection in humans. Most strains grow better at <37 degrees C, which can explain the rarity of infections in humans...
  78. Pandian T, Deziel P, Otley C, Eid A, Razonable R. Mycobacterium marinum infections in transplant recipients: case report and review of the literature. Transpl Infect Dis. 2008;10:358-63 pubmed publisher
    Infections due to Mycobacterium marinum are rarely encountered following organ and tissue transplantation. Herein, we report a case of M...
  79. Wang S, Dong X, Zhu Y, Wang C, Sun G, Luo T, et al. Revealing of Mycobacterium marinum transcriptome by RNA-seq. PLoS ONE. 2013;8:e75828 pubmed publisher
    ..In general, our study has primarily uncovered M. marinum transcriptome, which could help to gain a better understanding of the regulation system in Mtb that underlines disease pathogenesis. ..
  80. Gatt R, Cushieri P, Sciberras C. An unusual case of flexor sheath tenosynovitis. J Hand Surg Br. 1998;23:698-9 pubmed
    We report a case of a flexor sheath tenosynovitis caused by Mycobacterium marinum.
  81. Rybniker J, Wolke M, Haefs C, Plum G. Transposition of Tn5367 in Mycobacterium marinum, using a conditionally recombinant mycobacteriophage. J Bacteriol. 2003;185:1745-8 pubmed
    b>Mycobacterium marinum is a close relative of the obligate human pathogen Mycobacterium tuberculosis. As with M. tuberculosis, M. marinum causes intracellular infection of poikilothermic vertebrates and skin infection in humans...
  82. Stinear T, Seemann T, Pidot S, Frigui W, Reysset G, Garnier T, et al. Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res. 2007;17:192-200 pubmed
    ..Comparisons with the recently completed 6.6-Mb genome of Mycobacterium marinum revealed >98% nucleotide sequence identity and genome-wide synteny. However, as well as the plasmid, M...
  83. Subbian S, Mehta P, Cirillo S, Cirillo J. The Mycobacterium marinum mel2 locus displays similarity to bacterial bioluminescence systems and plays a role in defense against reactive oxygen and nitrogen species. BMC Microbiol. 2007;7:4 pubmed
    ..We recently identified a locus in Mycobacterium marinum, mel2, that plays a role during infection of macrophages...
  84. Stinear T, Seemann T, Harrison P, Jenkin G, Davies J, Johnson P, et al. Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res. 2008;18:729-41 pubmed publisher
    b>Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of the M strain of M...
  85. Palamaras I, Pietropaolo N, el Jabbour J, Thomson P, Dissanayake M, Robles W, et al. Axonal sensory neuropathy in a patient treated with minocycline for fish-tank granuloma. J Eur Acad Dermatol Venereol. 2008;22:765-6 pubmed publisher
  86. Abdallah A, Verboom T, Weerdenburg E, Gey van Pittius N, Mahasha P, Jiménez C, et al. PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5. Mol Microbiol. 2009;73:329-40 pubmed publisher
    ..Here, we have determined the secretome of ESX-5 by a proteomic approach in two different strains of Mycobacterium marinum. Comparison of the secretion profile of wild-type strains and their ESX-5 mutants showed that a number of ..
  87. Volkman H, Pozos T, Zheng J, Davis J, Rawls J, Ramakrishnan L. Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. Science. 2010;327:466-9 pubmed publisher
    ..However, analysis of Mycobacterium marinum in zebrafish has shown that the early granuloma facilitates mycobacterial growth; uninfected macrophages ..
  88. Gao L, Laval F, Lawson E, Groger R, Woodruff A, Morisaki J, et al. Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy. Mol Microbiol. 2003;49:1547-63 pubmed
    ..tuberculosis to grow within host macrophages, a property required for pathogenesis of infection. Mycobacterium marinum is an established model for discovering genes involved in mycobacterial infection...
  89. Tan T, Lee W, Alexander D, Grinstein S, Liu J. The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation. Cell Microbiol. 2006;8:1417-29 pubmed
    ..In this study, we isolated a mutant of Mycobacterium marinum defective in the secretion of ESAT-6 and CFP-10...
  90. Broussard G, Ennis D. Mycobacterium marinum produces long-term chronic infections in medaka: a new animal model for studying human tuberculosis. Comp Biochem Physiol C Toxicol Pharmacol. 2007;145:45-54 pubmed
    ..b>Mycobacterium marinum may be a good surrogate pathogen, conferring TB-like chronic infections in some fish...
  91. Harriff M, Bermudez L, Kent M. Experimental exposure of zebrafish, Danio rerio (Hamilton), to Mycobacterium marinum and Mycobacterium peregrinum reveals the gastrointestinal tract as the primary route of infection: a potential model for environmental mycobacterial infection. J Fish Dis. 2007;30:587-600 pubmed
    ..Danio rerio (Hamilton) were exposed by bath immersion and intubation to Mycobacterium marinum and Mycobacterium peregrinum isolates obtained from diseased zebrafish...
  92. Driessen N, Stoop E, Ummels R, Gurcha S, Mishra A, Larrouy Maumus G, et al. Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan. Microbiology. 2010;156:3492-502 pubmed publisher
    ..Here, we report that a third gene is involved, MMAR_2380, which is the Mycobacterium marinum orthologue of Rv1565c. MMAR_2380 encodes a predicted transmembrane acyltransferase. In M...