mycobacterium avium

Summary

Summary: A bacterium causing tuberculosis in domestic fowl and other birds. In pigs, it may cause localized and sometimes disseminated disease. The organism occurs occasionally in sheep and cattle. It should be distinguished from the M. avium complex, which infects primarily humans.

Top Publications

  1. Souza C, Evanson O, Weiss D. Mitogen activated protein kinase p38 pathway is an important component of the anti-inflammatory response in Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes. Microb Pathog. 2006;41:59-66 pubmed
    ..p38) pathway on the antimicrobial functions and cytokine expression by bovine monocytes after ingestion of Mycobacterium avium subsp. paratuberculosis...
  2. Yamazaki Y, Danelishvili L, Wu M, Macnab M, Bermudez L. Mycobacterium avium genes associated with the ability to form a biofilm. Appl Environ Microbiol. 2006;72:819-25 pubmed
    b>Mycobacterium avium is widely distributed in the environment, and it is chiefly found in water and soil. M. avium, as well as Mycobacterium smegmatis, has been recognized to produce a biofilm or biofilm-like structure. We screened an M...
  3. Biet F, Bay S, Thibault V, Euphrasie D, Grayon M, Ganneau C, et al. Lipopentapeptide induces a strong host humoral response and distinguishes Mycobacterium avium subsp. paratuberculosis from M. avium subsp. avium. Vaccine. 2008;26:257-68 pubmed
    ..These surface-located GPLs are involved in pathogenicity by interfering with the host immune system. In Mycobacterium avium subsp...
  4. Murphy J, Sommer S, Kabara E, Verman N, Kuelbs M, Saama P, et al. Gene expression profiling of monocyte-derived macrophages following infection with Mycobacterium avium subspecies avium and Mycobacterium avium subspecies paratuberculosis. Physiol Genomics. 2006;28:67-75 pubmed
    b>Mycobacterium avium subspecies paratuberculosis (MAP) and Mycobacterium avium subspecies avium (MAA) represent two closely related intracellular bacteria with vastly different associated pathologies...
  5. Feller M, Huwiler K, Stephan R, Altpeter E, Shang A, Furrer H, et al. Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis. Lancet Infect Dis. 2007;7:607-13 pubmed
    This systematic review assesses the evidence for an association between Mycobacterium avium subspecies paratuberculosis (MAP) and Crohn's disease...
  6. Turenne C, Collins D, Alexander D, Behr M. Mycobacterium avium subsp. paratuberculosis and M. avium subsp. avium are independently evolved pathogenic clones of a much broader group of M. avium organisms. J Bacteriol. 2008;190:2479-87 pubmed publisher
    b>Mycobacterium avium comprises organisms that share the same species designation despite considerable genomic and phenotypic variability. To determine the degree and nature of variability between subspecies and strains of M...
  7. Wagner D, Maser J, Moric I, Vogt S, Kern W, Bermudez L. Elemental analysis of the Mycobacterium avium phagosome in Balb/c mouse macrophages. Biochem Biophys Res Commun. 2006;344:1346-51 pubmed
    ..macrophages from C57BL/6 mice, the phagosome of pathogenic mycobacteria (Mycobacterium tuberculosis and Mycobacterium avium) can accumulate iron. We expanded our studies to the M...
  8. Geier H, Mostowy S, Cangelosi G, Behr M, Ford T. Autoinducer-2 triggers the oxidative stress response in Mycobacterium avium, leading to biofilm formation. Appl Environ Microbiol. 2008;74:1798-804 pubmed publisher
    b>Mycobacterium avium is an environmental organism and opportunistic pathogen with inherent resistance to drugs, environmental stresses, and the host immune response. To adapt to these disparate conditions, M...
  9. Brugnera M, Miyata M, Zocolo G, Leite C, Zanoni M. A photoelectrocatalytic process that disinfects water contaminated with Mycobacterium kansasii and Mycobacterium avium. Water Res. 2013;47:6596-605 pubmed publisher
    ..9 and 99.8% inactivation of Mycobacterium kansasii and Mycobacterium avium with rate constant of 6.2 × 10(-3) and 4.2 × 10(-3) min(-1), respectively, after 240 min...

More Information

Publications137 found, 100 shown here

  1. Semret M, Turenne C, de Haas P, Collins D, Behr M. Differentiating host-associated variants of Mycobacterium avium by PCR for detection of large sequence polymorphisms. J Clin Microbiol. 2006;44:881-7 pubmed
    The Mycobacterium avium species consists of a group of organisms that are genetically related but phenotypically diverse, with certain variants presenting clear differences in terms of their host association and disease manifestations...
  2. Freeman R, Geier H, Weigel K, Do J, Ford T, Cangelosi G. Roles for cell wall glycopeptidolipid in surface adherence and planktonic dispersal of Mycobacterium avium. Appl Environ Microbiol. 2006;72:7554-8 pubmed
    The opportunistic pathogen Mycobacterium avium is a significant inhabitant of biofilms in drinking water distribution systems. M. avium expresses on its cell surface serovar-specific glycopeptidolipids (ssGPLs)...
  3. Basler T, Brumshagen C, Beineke A, Goethe R, Baumer W. Mycobacterium avium subspecies impair dendritic cell maturation. Innate Immun. 2013;19:451-61 pubmed publisher
    b>Mycobacterium avium ssp. paratuberculosis (MAP) causes Johne's disease, a chronic, granulomatous enteritis of ruminants...
  4. Nakahara H, Kamide Y, Hamano Y, Hosokawa T, Nishide M, Lin Y, et al. A case report of a patient with rheumatoid arthritis complicated with Mycobacterium avium during tocilizumab treatment. Mod Rheumatol. 2011;21:655-9 pubmed publisher
    A female patient with rheumatoid arthritis (RA) suffered from Mycobacterium avium (M. avium) infection during tocilizumab treatment...
  5. Harrenstien L, Finnegan M, Woodford N, Mansfield K, Waters W, Bannantine J, et al. Mycobacterium avium in pygmy rabbits (Brachylagus idahoensis): 28 cases. J Zoo Wildl Med. 2006;37:498-512 pubmed
    ..Disseminated mycobacteriosis due to Mycobacterium avium has been the most common cause of death of adult captive pygmy rabbits...
  6. Agdestein A, Johansen T, Kolbjørnsen Ø, Jørgensen A, Djønne B, Olsen I. A comparative study of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis in experimentally infected pigs. BMC Vet Res. 2012;8:11 pubmed publisher
    b>Mycobacterium avium subsp. avium (Maa) and Mycobacterium avium subsp. hominissuis (Mah) are opportunistic pathogens that may infect several species, including humans and pigs...
  7. Marsh I, Whittington R. Genomic diversity in Mycobacterium avium: single nucleotide polymorphisms between the S and C strains of M. avium subsp. paratuberculosis and with M. a. avium. Mol Cell Probes. 2007;21:66-75 pubmed
    ..to identify single nucleotide polymorphisms (SNPs) in 25 genes in the sheep (S) and cattle (C) strains of Mycobacterium avium subsp. paratuberculosis (M. a. paratuberculosis) and between M. a. paratuberculosis and M. a. avium...
  8. Piao Z, Shibayama K, Mori S, Wachino J, Arakawa Y. A novel insertion sequence, IS1642, of Mycobacterium avium, which forms long direct repeats of variable length. FEMS Microbiol Lett. 2009;291:216-21 pubmed publisher
    A new insertion sequence (IS), IS1642, was identified in a Mycobacterium avium strain isolated from a human patient...
  9. Sevilla I, Garrido J, Geijo M, Juste R. Pulsed-field gel electrophoresis profile homogeneity of Mycobacterium avium subsp. paratuberculosis isolates from cattle and heterogeneity of those from sheep and goats. BMC Microbiol. 2007;7:18 pubmed
    b>Mycobacterium avium subsp. paratuberculosis (Map) causes paratuberculosis in animals and is suspected of causing Crohn's Disease in humans...
  10. Fujita M, Harada E, Matsumoto T, Mizuta Y, Ikegame S, Ouchi H, et al. Impaired host defence against Mycobacterium avium in mice with chronic granulomatous disease. Clin Exp Immunol. 2010;160:457-60 pubmed publisher
    ..To determine whether or not NADPH oxidase is crucial to the host defence against Mycobacterium avium, we investigated the response against M. avium using CGD model mice (gp91-phox(-)) of C57BL/6 strain...
  11. Alvarez J, Castellanos E, Romero B, Aranaz A, Bezos J, Rodriguez S, et al. Epidemiological investigation of a Mycobacterium avium subsp. hominissuis outbreak in swine. Epidemiol Infect. 2011;139:143-8 pubmed publisher
    b>Mycobacterium avium subsp. hominissuis (MAH) infection in swine may cause granulomatous lesions in lymph nodes that must undergo differential diagnosis with those caused by M. tuberculosis complex members...
  12. Stabel J, Barnhill A, Bannantine J, Chang Y, Osman M. Evaluation of protection in a mouse model after vaccination with Mycobacterium avium subsp. paratuberculois protein cocktails. Vaccine. 2012;31:127-34 pubmed publisher
    Whole-cell vaccines successfully reduce signs of clinical disease and fecal shedding of Mycobacterium avium subsp. paratuberculosis (MAP), however, these vaccines have some limitations...
  13. Ichikawa K, Yagi T, Moriyama M, Inagaki T, Nakagawa T, Uchiya K, et al. Characterization of Mycobacterium avium clinical isolates in Japan using subspecies-specific insertion sequences, and identification of a new insertion sequence, ISMav6. J Med Microbiol. 2009;58:945-50 pubmed publisher
    Clinical isolates of Mycobacterium avium (n=81) from patients with pulmonary infections who were HIV-negative and isolates (n=33) from HIV-positive patients were subjected to genetic analysis by PCR detection of three M...
  14. Dagleish M, Stevenson K, Foster G, McLuckie J, Sellar M, Harley J, et al. Mycobacterium avium subsp. hominissuis Infection in a captive-bred kiang (Equus kiang). J Comp Pathol. 2012;146:372-7 pubmed publisher
    ..species reported, although a single report exists of disease due to definitively diagnosed infection with Mycobacterium avium subsp. hominissuis in two domestic horses...
  15. Barber D, Andrade B, McBerry C, Sereti I, Sher A. Role of IL-6 in Mycobacterium avium--associated immune reconstitution inflammatory syndrome. J Immunol. 2014;192:676-82 pubmed publisher
    ..protein levels transiently rise at the time of the IRIS event in HIV-infected patients, unmasking Mycobacterium avium complex infection after starting antiretroviral therapy...
  16. Harris N, Payeur J, Kapur V, Sreevatsan S. Short-sequence-repeat analysis of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium isolates collected from animals throughout the United States reveals both stability of loci and extensive diversity. J Clin Microbiol. 2006;44:2970-3 pubmed
    We analyzed the multilocus short sequence repeats (SSRs) of 211 and 56 isolates of Mycobacterium avium subsp. paratuberculosis and M. avium subsp. avium, respectively. The M. avium subsp...
  17. Möbius P, Fritsch I, Luyven G, Hotzel H, Köhler H. Unique genotypes of Mycobacterium avium subsp. paratuberculosis strains of Type III. Vet Microbiol. 2009;139:398-404 pubmed publisher
    b>Mycobacterium avium subsp...
  18. Komijn R, Wisselink H, Rijsman V, Stockhofe Zurwieden N, Bakker D, van Zijderveld F, et al. Granulomatous lesions in lymph nodes of slaughter pigs bacteriologically negative for Mycobacterium avium subsp. avium and positive for Rhodococcus equi. Vet Microbiol. 2007;120:352-7 pubmed
    ..1%) pig showed lesions in its mesenteric lymph node. Mycobacterium avium subsp...
  19. Bermudez L, Motamedi N, Kolonoski P, Chee C, Baimukanova G, Bildfell R, et al. The efficacy of clarithromycin and the bicyclolide EDP-420 against Mycobacterium avium in a mouse model of pulmonary infection. J Infect Dis. 2008;197:1506-10 pubmed publisher
    Lung disease caused by Mycobacterium avium complex (MAC) is increasing in prevalence...
  20. Agarwal R, Nath A. Hot-tub lung: hypersensitivity to Mycobacterium avium but not hypersensitivity pneumonitis. Respir Med. 2006;100:1478 pubmed
  21. Torvinen E, Lehtola M, Martikainen P, Miettinen I. Survival of Mycobacterium avium in drinking water biofilms as affected by water flow velocity, availability of phosphorus, and temperature. Appl Environ Microbiol. 2007;73:6201-7 pubmed
    b>Mycobacterium avium is a potential pathogen occurring in drinking water systems. It is a slowly growing bacterium producing a thick cell wall containing mycolic acids, and it is known to resist chlorine better than many other microbes...
  22. Kikuchi T, Watanabe A, Gomi K, Sakakibara T, Nishimori K, Daito H, et al. Association between mycobacterial genotypes and disease progression in Mycobacterium avium pulmonary infection. Thorax. 2009;64:901-7 pubmed publisher
    Non-tuberculous mycobacterial lung disease, most commonly caused by Mycobacterium avium infection, tends to show variable disease progression, and significant disease predictors have not been adequately established...
  23. Ariki S, Kojima T, Gasa S, Saito A, Nishitani C, Takahashi M, et al. Pulmonary collectins play distinct roles in host defense against Mycobacterium avium. J Immunol. 2011;187:2586-94 pubmed publisher
    ..b>Mycobacterium avium is one of the well-known opportunistic pathogens that can replicate within macrophages...
  24. Parra M, Cadieux N, Pickett T, Dheenadhayalan V, Brennan M. A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen. Infect Immun. 2006;74:786-9 pubmed
    Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited...
  25. Young S, Slobbe L, Wilson R, Buddle B, de Lisle G, Buchan G. Environmental strains of Mycobacterium avium interfere with immune responses associated with Mycobacterium bovis BCG vaccination. Infect Immun. 2007;75:2833-40 pubmed
    ..In this study, two strains of Mycobacterium avium, both isolated from New Zealand livestock, were investigated to determine their growth characteristics and ..
  26. Turenne C, Wallace R, Behr M. Mycobacterium avium in the postgenomic era. Clin Microbiol Rev. 2007;20:205-29 pubmed
    The past several years have witnessed an upsurge of genomic data pertaining to the Mycobacterium avium complex (MAC)...
  27. Johar M, Manning T, Tse C, Desroches N, Agrawal B, Kunimoto D, et al. Growth inhibition of Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium in vitro: effect of 1-beta-D-2'-arabinofuranosyl and 1-(2'-deoxy-2'-fluoro-beta-D-2'-ribofuranosyl) pyrimidine nucleoside analogs. J Med Chem. 2007;50:3696-705 pubmed
    ..tuberculosis H37Rv at similar concentrations. Some of these analogs also revealed in vitro antimicrobial effect against several other gram-positive pathogens. ..
  28. Luh J, Tong N, Raskin L, Mariñas B. Inactivation of Mycobacterium avium with monochloramine. Environ Sci Technol. 2008;42:8051-6 pubmed
    Batch experiments were performed to study the inactivation kinetics of Mycobacterium avium in the presence of monochloramine at 5-30 degrees C, pH 6-10, and 0.30-42.3 mg Cl2/ L...
  29. Greenstein R, Su L, Brown S. The thioamides methimazole and thiourea inhibit growth of M. avium Subspecies paratuberculosis in culture. PLoS ONE. 2010;5:e11099 pubmed publisher
    ..compelling data that another "autoimmune" affliction, Crohn disease, may be caused by Mycobacterium avium subspecies paratuberculosis (MAP). Like M. tb, MAP is systemic...
  30. Barber D, Mayer Barber K, Antonelli L, Wilson M, White S, Caspar P, et al. Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice. Blood. 2010;116:3485-93 pubmed publisher
    ..Here, we show that Mycobacterium avium-infected T cell-deficient mice injected with CD4 T cells also develop an immune reconstitution disease (IRD)..
  31. Johansen T, Olsen I, Jensen M, Dahle U, Holstad G, Djønne B. New probes used for IS1245 and IS1311 restriction fragment length polymorphism of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis isolates of human and animal origin in Norway. BMC Microbiol. 2007;7:14 pubmed
    b>Mycobacterium avium is an environmental mycobacterium that can be divided into the subspecies avium, hominissuis, paratuberculosis and silvaticum. Some M. avium subspecies are opportunistic pathogens for animals and humans...
  32. Schrenzel M, Nicolas M, Witte C, Papendick R, Tucker T, Keener L, et al. Molecular epidemiology of Mycobacterium avium subsp. avium and Mycobacterium intracellulare in captive birds. Vet Microbiol. 2008;126:122-31 pubmed
    b>Mycobacterium avium subsp. avium and Mycobacterium intracellulare are primary causes of mycobacteriosis in captive birds throughout the world, but little is known about how they are transmitted...
  33. Ignatov D, Malakho S, Majorov K, Skvortsov T, Apt A, Azhikina T. RNA-Seq analysis of Mycobacterium avium non-coding transcriptome. PLoS ONE. 2013;8:e74209 pubmed publisher
    Deep sequencing was implemented to study the transcriptional landscape of Mycobacterium avium. High-resolution transcriptome analysis identified the transcription start points for 652 genes...
  34. Flaherty D, Vesosky B, Beamer G, Stromberg P, Turner J. Exposure to Mycobacterium avium can modulate established immunity against Mycobacterium tuberculosis infection generated by Mycobacterium bovis BCG vaccination. J Leukoc Biol. 2006;80:1262-71 pubmed
    ..Mice were vaccinated with BCG and subsequently given repeated oral doses of live Mycobacterium avium to model exposure to environmental mycobacteria...
  35. Sechi L, Gazouli M, Sieswerda L, Molicotti P, Ahmed N, Ikonomopoulos J, et al. Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients. World J Gastroenterol. 2006;12:7161-4 pubmed
    To study the association between Crohn's disease (CD), Mycobacterium avium subspecies paratuberculosis (MAP), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (..
  36. Woo S, Barletta R, Czuprynski C. Extracellular ATP is cytotoxic to mononuclear phagocytes but does not induce killing of intracellular Mycobacterium avium subsp. paratuberculosis. Clin Vaccine Immunol. 2007;14:1078-83 pubmed
    b>Mycobacterium avium subsp. paratuberculosis is the etiologic agent of Johne's disease, a chronic granulomatous enteritis in ruminants...
  37. Lehtola M, Torvinen E, Miettinen I, Keevil C. Fluorescence in situ hybridization using peptide nucleic acid probes for rapid detection of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. paratuberculosis in potable-water biofilms. Appl Environ Microbiol. 2006;72:848-53 pubmed
    ..for the first time a high-affinity peptide nucleic acid (PNA) oligonucleotide sequence for detecting Mycobacterium avium bacteria, including the opportunistically pathogenic subspecies M. avium subsp. avium, M. avium subsp...
  38. Chinen L, Cipriano I, de Oliveira R, Leão S, Mariano M, Carneiro C. Recombinant interleukin-4-treated macrophages, epithelioid cell surrogates, harbor and arrest Mycobacterium avium multiplication in vitro. Microbes Infect. 2006;8:965-73 pubmed
    ..T-cell lymphoproliferation assays using ovalbumin (OVA) and Mycobacterium avium as antigens showed that both cultured macrophages were equally efficient as antigen presenting cells (APCs)...
  39. Wisselink H, van Solt Smits C, Oorburg D, van Soolingen D, Overduin P, Maneschijn Bonsing J, et al. Serodiagnosis of Mycobacterium avium infections in pigs. Vet Microbiol. 2010;142:401-7 pubmed publisher
    The aim of this study is the development and evaluation of a serodiagnostic assay for Mycobacterium avium (MA)...
  40. Danelishvili L, Wu M, Stang B, Harriff M, Cirillo S, Cirillo S, et al. Identification of Mycobacterium avium pathogenicity island important for macrophage and amoeba infection. Proc Natl Acad Sci U S A. 2007;104:11038-43 pubmed
    The ability to infect macrophages is a common characteristic shared among many mycobacterial species. Mycobacterium avium, Mycobacterium tuberculosis, and Mycobacterium kansasii enter macrophages, using the complement receptors CR1, CR3, ..
  41. Dominici S, Brandi G, Schiavano G, Magnani M. Selective killing of Mycobacterium avium-infected macrophages by inhibition of phosphorylated signal transducer and activator of transcription type 1. J Infect Dis. 2008;198:95-100 pubmed publisher
    b>Mycobacterium avium infects mononuclear phagocytes, which thereby become reservoirs for this pathogen. Currently recommended therapy does not ensure the eradication of intracellular bacteria. Here, we report that M...
  42. Garrido J, Vicente J, Carrasco García R, Galindo R, Minguijon E, Ballesteros C, et al. Experimental infection of Eurasian wild boar with Mycobacterium avium subsp. avium. Vet Microbiol. 2010;144:240-5 pubmed publisher
    ..We aimed to characterize the first experimental Mycobacterium avium subsp...
  43. Klanicova B, Slana I, Vondruskova H, Kaevska M, Pavlik I. Real-time quantitative PCR detection of Mycobacterium avium subspecies in meat products. J Food Prot. 2011;74:636-40 pubmed publisher
    The aim of this work was to examine various purchased meat products and to find out if any traces of Mycobacterium avium subsp. avium, M. avium subsp. hominissuis, and M. avium subsp. paratuberculosis could be detected in these samples...
  44. Wu C, Glasner J, Collins M, Naser S, Talaat A. Whole-genome plasticity among Mycobacterium avium subspecies: insights from comparative genomic hybridizations. J Bacteriol. 2006;188:711-23 pubmed
    Infection with Mycobacterium avium subsp. paratuberculosis causes Johne's disease in cattle and is also implicated in cases of Crohn's disease in humans. Another closely related strain, M. avium subsp...
  45. Barry D, Beaman B. Modulation of eukaryotic cell apoptosis by members of the bacterial order Actinomycetales. Apoptosis. 2006;11:1695-707 pubmed
    ..Rather than covering the entire field, this review focuses on the dysregulation of host cell apoptosis by members of the order Actinomycetales, containing the genera Corynebacterium, Mycobacterium, Rhodococcus, and Nocardia...
  46. Feng C, Weksberg D, Taylor G, Sher A, Goodell M. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell. 2008;2:83-9 pubmed publisher
    ..repopulation assays, and when challenged with hematopoietic ablation by 5-fluorouracil or infection with Mycobacterium avium, Lrg-47(-/-) mice fail to achieve the expected expansion response in stem and progenitor cell populations...
  47. Noh K, Shin S, Son K, Jung I, Kang H, Lee S, et al. The Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein, a toll-like receptor 4 agonist, enhances dendritic cell-based cancer vaccine potency. Exp Mol Med. 2012;44:340-9 pubmed publisher
    In this study, we showed the direct interaction between Mycobacterium avium subsp...
  48. Shitaye J, Matlova L, Horvathova A, Moravkova M, Dvorska Bartosova L, Treml F, et al. Mycobacterium avium subsp. avium distribution studied in a naturally infected hen flock and in the environment by culture, serotyping and IS901 RFLP methods. Vet Microbiol. 2008;127:155-64 pubmed
    b>Mycobacterium avium subsp. avium (MAA) of serotype 2 and genotype IS901+ and IS1245+ was cultured from 21 naturally infected hens (Gallus domesticus) from one smallholder aviary...
  49. Greenstein R, Su L, Juste R, Brown S. On the action of cyclosporine A, rapamycin and tacrolimus on M. avium including subspecies paratuberculosis. PLoS ONE. 2008;3:e2496 pubmed publisher
    b>Mycobacterium avium subspecies paratuberculosis (MAP) may be zoonotic...
  50. Gomes Pereira S, Rodrigues P, Appelberg R, Gomes M. Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice. Infect Immun. 2008;76:4713-9 pubmed publisher
    b>Mycobacterium avium is an opportunistic infectious agent in immunocompromised patients, living inside macrophage phagosomes. As for other mycobacterial species, iron availability is a critical factor for M...
  51. Halaas O, Steigedal M, Haug M, Awuh J, Ryan L, Brech A, et al. Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway. J Infect Dis. 2010;201:783-92 pubmed publisher
    ..Here we show that Lcn2 suppressed growth of Mycobacterium avium in culture, and M. avium induced Lcn2 production from mouse macrophages...
  52. Falkinham J, Iseman M, de Haas P, van Soolingen D. Mycobacterium avium in a shower linked to pulmonary disease. J Water Health. 2008;6:209-13 pubmed publisher
    b>Mycobacterium avium was isolated from hot and cold water samples and from sediment (biofilm) collected from the showerhead in the home of a woman with M. avium pulmonary disease lacking known M. avium risk factors...
  53. Sweet L, Zhang W, Torres Fewell H, Serianni A, Boggess W, Schorey J. Mycobacterium avium glycopeptidolipids require specific acetylation and methylation patterns for signaling through toll-like receptor 2. J Biol Chem. 2008;283:33221-31 pubmed publisher
    ..Recent studies from our laboratory indicate that glycopeptidolipids (GPLs), a major surface component of Mycobacterium avium and other non-tuberculosis mycobacteria, are ligands for TLR2...
  54. Sharbati J, Lewin A, Kutz Lohroff B, Kamal E, Einspanier R, Sharbati S. Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection. PLoS ONE. 2011;6:e20258 pubmed publisher
    ..microRNA as well as mRNA expression analysis of human monocyte derived macrophages infected with several Mycobacterium avium hominissuis strains by means of microarrays as well as quantitative reverse transcription PCR (qRT-PCR)...
  55. Tirkkonen T, Pakarinen J, Rintala E, Ali Vehmas T, Marttila H, Peltoniemi O, et al. Comparison of variable-number tandem-repeat markers typing and IS1245 restriction fragment length polymorphism fingerprinting of Mycobacterium avium subsp. hominissuis from human and porcine origins. Acta Vet Scand. 2010;52:21 pubmed publisher
    ..mycobacterial interspersed repetitive units (MIRUs), was evaluated for its ability to characterize Finnish Mycobacterium avium subsp...
  56. Harriff M, Danelishvili L, Wu M, Wilder C, McNamara M, Kent M, et al. Mycobacterium avium genes MAV_5138 and MAV_3679 are transcriptional regulators that play a role in invasion of epithelial cells, in part by their regulation of CipA, a putative surface protein interacting with host cell signaling pathways. J Bacteriol. 2009;191:1132-42 pubmed publisher
    The Mycobacterium avium complex (MAC) is an important group of opportunistic pathogens for birds, cattle, swine, and immunosuppressed humans...
  57. Sweet L, Singh P, Azad A, Rajaram M, Schlesinger L, Schorey J. Mannose receptor-dependent delay in phagosome maturation by Mycobacterium avium glycopeptidolipids. Infect Immun. 2010;78:518-26 pubmed publisher
    ..that phagosomes containing silica beads coated with glycopeptidolipids (GPLs), a major surface component of Mycobacterium avium, showed limited acidification and delayed recruitment of late endosomal/lysosomal markers compared to those ..
  58. Reed C, von Reyn C, Chamblee S, Ellerbrock T, Johnson J, Marsh B, et al. Environmental risk factors for infection with Mycobacterium avium complex. Am J Epidemiol. 2006;164:32-40 pubmed
    Infection with Mycobacterium avium complex is acquired from the environment, but risk factors for M. avium complex infection and disease are poorly understood...
  59. Sweet L, Schorey J. Glycopeptidolipids from Mycobacterium avium promote macrophage activation in a TLR2- and MyD88-dependent manner. J Leukoc Biol. 2006;80:415-23 pubmed
    ..susceptible to infection by Mycobacterium tuberculosis, Mycobacterium bovis bacillus Calmette-Guerin, and Mycobacterium avium. Therefore, it is important to define the molecules expressed by pathogenic mycobacteria, which bind the ..
  60. Gomes M, Sousa Fernandes S, Cordeiro J, Silva Gomes S, Vieira A, Appelberg R. Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity. Eur J Immunol. 2008;38:2180-9 pubmed publisher
    ..immune response to mycobacterial infections, being required for optimal immunity against certain virulent Mycobacterium avium strains. Here we analyzed the role of TLR2 in the intra-macrophagic growth of M...
  61. L Abbate C, Cipriano I, Perez Hurtado E, Leao S, Carneiro C, Machado J. TGF-?-mediated sustained ERK1/2 activity promotes the inhibition of intracellular growth of Mycobacterium avium in epithelioid cells surrogates. PLoS ONE. 2011;6:e21465 pubmed publisher
    ..in the pathogenesis of several diseases including infection with intracellular pathogens such as the Mycobacterium avium complex. Infection of macrophages with M...
  62. Tenant R, Bermudez L. Mycobacterium avium genes upregulated upon infection of Acanthamoeba castellanii demonstrate a common response to the intracellular environment. Curr Microbiol. 2006;52:128-33 pubmed
    Using a previously created Mycobacterium avium genomic library with GFP-promoter trap in Mycobacterium smegmatis, we screened for genes that are upregulated upon infection of A. castellanii. Clones exhibiting a 2...
  63. Vazquez N, Greenwell Wild T, Rekka S, Orenstein J, Wahl S. Mycobacterium avium-induced SOCS contributes to resistance to IFN-gamma-mediated mycobactericidal activity in human macrophages. J Leukoc Biol. 2006;80:1136-44 pubmed
    b>Mycobacterium avium is an opportunistic pathogen that commonly infects individuals colonized with HIV-1, although it is less frequent in the post-HAART era...
  64. Aly S, Laskay T, Mages J, Malzan A, Lang R, Ehlers S. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol. 2007;212:295-305 pubmed
    ..Lung histopathology of C57BL/6 (WT) mice 16 weeks after aerosol infection with Mycobacterium avium strain TMC724 is uniquely characterized by centrally necrotizing granulomas, strongly resembling human TB ..
  65. Jha S, Danelishvili L, Wagner D, Maser J, Li Y, Moric I, et al. Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages. BMC Microbiol. 2010;10:100 pubmed publisher
    b>Mycobacterium avium subsp hominissuis (previously Mycobacterium avium subsp avium) is an environmental organism associated with opportunistic infections in humans...
  66. Thomson R, Carter R, Gilpin C, Coulter C, Hargreaves M. Comparison of methods for processing drinking water samples for the isolation of Mycobacterium avium and Mycobacterium intracellulare. Appl Environ Microbiol. 2008;74:3094-8 pubmed publisher
    ..This study compared methods of processing potable water samples for the isolation of Mycobacterium avium and Mycobacterium intracellulare using spiked sterilized water and tap water decontaminated using 0...
  67. Crawford G, Ziccardi M, Gonzales B, Woods L, Fischer J, Manning E, et al. Mycobacterium avium subspecies paratuberculosis and Mycobacterium avium subsp. avium infections in a tule elk (Cervus elaphus nannodes) herd. J Wildl Dis. 2006;42:715-23 pubmed
    ..were identified by a multiplex polymerase chain reaction (PCR) that discriminates among members of the Mycobacterium avium complex (MAC)...
  68. Roque S, Nobrega C, Appelberg R, Correia Neves M. IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy. J Immunol. 2007;178:8028-35 pubmed
    ..Our results show that BALB/c mice are more susceptible than C57BL/6 to Mycobacterium avium infection...
  69. Selby W, Pavli P, Crotty B, Florin T, Radford Smith G, Gibson P, et al. Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease. Gastroenterology. 2007;132:2313-9 pubmed
    b>Mycobacterium avium subspecies paratuberculosis has been proposed as a cause of Crohn's disease...
  70. Riddell J, Kaul D, Karakousis P, Gallant J, Mitty J, Kazanjian P. Mycobacterium avium complex immune reconstitution inflammatory syndrome: long term outcomes. J Transl Med. 2007;5:50 pubmed
    To describe long term outcomes of Mycobacterium avium complex (MAC) immune reconstitution inflammatory syndrome (IRIS).
  71. Singh A, Singh S, Sohal J, Singh P. Comparative potential of modified indigenous, indigenous and commercial ELISA kits for diagnosis of Mycobacterium avium subspecies paratuberculosis in goat and sheep. Indian J Exp Biol. 2009;47:379-82 pubmed
    ..7%) and kit 2 (83.4%). Kit 1 showed superior diagnostic potential than the other two kits. Kit 1 may be used as single screening test regimen for diagnosis of MAP infection in the population of goats and sheep in India...
  72. Li Y, Danelishvili L, Wagner D, Petrofsky M, Bermudez L. Identification of virulence determinants of Mycobacterium avium that impact on the ability to resist host killing mechanisms. J Med Microbiol. 2010;59:8-16 pubmed publisher
    b>Mycobacterium avium is an opportunistic pathogen associated with pulmonary disease in non-AIDS patients and disseminated infection in patients with AIDS...
  73. Carvalho N, Oliveira F, Durães F, de Almeida L, Flórido M, Prata L, et al. Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses. Infect Immun. 2011;79:1638-46 pubmed publisher
    To investigate the role of Toll-like receptor 9 (TLR9) in innate immunity to Mycobacterium avium, TLR9, TLR2, and MyD88 knockout (KO) mice were infected with this bacterium...
  74. Agdestein A, Johansen T, Polaček V, Lium B, Holstad G, Vidanovic D, et al. Investigation of an outbreak of mycobacteriosis in pigs. BMC Vet Res. 2011;7:63 pubmed publisher
    ..An investigation of potential mycobacteriosis in the pigs imported to Serbia and the possible source of infection in the Lithuanian herd were therefore initialised...
  75. Stepanova H, Pavlova B, Stromerova N, Ondrackova P, Stejskal K, Slana I, et al. Different immune response of pigs to Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis infection. Vet Microbiol. 2012;159:343-50 pubmed publisher
    b>Mycobacterium avium subsp. avium (MAA) and Mycobacterium avium subsp. hominissuis (MAH) are the most common mycobacterial species isolated from granulomatous lesions in swine in countries with controlled bovine tuberculosis...
  76. Caire Brändli I, Papadopoulos A, Malaga W, Marais D, Canaan S, Thilo L, et al. Reversible lipid accumulation and associated division arrest of Mycobacterium avium in lipoprotein-induced foamy macrophages may resemble key events during latency and reactivation of tuberculosis. Infect Immun. 2014;82:476-90 pubmed publisher
    ..We propose that VLDL-driven FM constitute a well-defined cellular system in which to study changed metabolic states of intracellular mycobacteria that may relate to persistence and reactivation of tuberculosis. ..
  77. Flórido M, Appelberg R. Genetic control of immune-mediated necrosis of Mycobacterium avium granulomas. Immunology. 2006;118:122-30 pubmed
    Intravenous infection of C57BL/6 and C57BL/10 mice with low doses of a highly virulent strain of Mycobacterium avium (ATCC 25291) led to the development of granulomas that underwent necrosis...
  78. Pickup R, Rhodes G, Bull T, Arnott S, Sidi Boumedine K, Hurley M, et al. Mycobacterium avium subsp. paratuberculosis in lake catchments, in river water abstracted for domestic use, and in effluent from domestic sewage treatment works: diverse opportunities for environmental cycling and human exposure. Appl Environ Microbiol. 2006;72:4067-77 pubmed
    b>Mycobacterium avium subsp. paratuberculosis from infected animals enters surface waters and rivers in runoff from contaminated pastures...
  79. Lafuse W, Alvarez G, Curry H, Zwilling B. Mycobacterium tuberculosis and Mycobacterium avium inhibit IFN- gamma -induced gene expression by TLR2-dependent and independent pathways. J Interferon Cytokine Res. 2006;26:548-61 pubmed
    ..the inhibition of IFN-gamma-induced gene expression by Mycobacterium tuberculosis and four different Mycobacterium avium strains in mouse RAW264.7 macrophages. Gamma-irradiated M...
  80. Semret M, Bakker D, Smart N, Olsen I, Haslov K, Behr M. Genetic analysis of Mycobacterium avium complex strains used for producing purified protein derivatives. Clin Vaccine Immunol. 2006;13:991-6 pubmed
    ..Among these, reagents to detect infections by Mycobacterium avium complex organisms have been produced, but the utility of these reagents has not been clearly established ..
  81. Singh S, Singh P, Singh A, Sohal J, Gupta V, Vihan V. Comparative efficacy of an indigenous 'inactivated vaccine' using highly pathogenic field strain of Mycobacterium avium subspecies paratuberculosis 'Bison type' with a commercial vaccine for the control of Capri-paratuberculosis in India. Vaccine. 2007;25:7102-10 pubmed
    ..Efficacy of 'indigenous vaccine' containing native 'Bison type' genotype of Mycobacterium avium subspecies paratuberculosis (MAP) was compared with commercial vaccine using challenge studies with ..
  82. de Steenwinkel J, van Vianen W, ten Kate M, Verbrugh H, van Agtmael M, Schiffelers R, et al. Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in mice. J Antimicrob Chemother. 2007;60:1064-73 pubmed
    ..Improvement of the efficacy of drug treatment in mycobacterial infection by the development and application of targeted drug delivery...
  83. Pate M, Zolnir Dovc M, Krt B, Ocepek M. IS1245 RFLP-based genotyping study of Mycobacterium avium subsp. hominissuis isolates from pigs and humans. Comp Immunol Microbiol Infect Dis. 2008;31:537-50 pubmed publisher
    b>Mycobacterium avium subsp. hominissuis, ubiquitous environmental mycobacterium, is an opportunistic pathogen that is regularly isolated from pigs and humans in Slovenia...
  84. Rodrigues L, Wagner D, Viveiros M, Sampaio D, Couto I, Vavra M, et al. Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis. J Antimicrob Chemother. 2008;61:1076-82 pubmed publisher
    Therapy of AIDS patients infected with Mycobacterium avium is problematic due to its intrinsic resistance to antibiotics. We have characterized the efflux pump activity of M...
  85. Hayes S, Sivaganesan M, White K, Pfaller S. Assessing the effectiveness of low-pressure ultraviolet light for inactivating Mycobacterium avium complex (MAC) micro-organisms. Lett Appl Microbiol. 2008;47:386-92 pubmed publisher
    To assess low-pressure ultraviolet light (LP-UV) inactivation kinetics of Mycobacterium avium complex (MAC) strains in a water matrix using collimated beam apparatus.
  86. Domingos M, Amado A, Botelho A. IS1245 RFLP analysis of strains of Mycobacterium avium subspecies hominissuis isolated from pigs with tuberculosis lymphadenitis in Portugal. Vet Rec. 2009;164:116-20 pubmed
    ..b>Mycobacterium avium subspecies hominissuis was identified as the cause of this outbreak of tuberculosis lymphadenitis by IS901 ..
  87. Chow J, Wu L, Yew W. Directed evolution of a quorum-quenching lactonase from Mycobacterium avium subsp. paratuberculosis K-10 in the amidohydrolase superfamily. Biochemistry. 2009;48:4344-53 pubmed publisher
    ..Using a quorum-quenching lactonase from Mycobacterium avium subsp...
  88. Fernandes S, Nunes A, Gomes A, de Castro B, Hider R, Rangel M, et al. Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium. Microbes Infect. 2010;12:287-94 pubmed publisher
    ..an array of iron chelating ligands of the 3-hydroxy-4-pyridinone family, in the intramacrophagic growth of Mycobacterium avium. We found that bidentate chelators, namely N-alkyl-3-hydroxy-4-pyridinones and N-aryl-3-hydroxy-4-..
  89. Ovrutsky A, Chan E, Kartalija M, Bai X, Jackson M, Gibbs S, et al. Cooccurrence of free-living amoebae and nontuberculous Mycobacteria in hospital water networks, and preferential growth of Mycobacterium avium in Acanthamoeba lenticulata. Appl Environ Microbiol. 2013;79:3185-92 pubmed publisher
    ..by Mycobacterium peregrinum (4/17), Mycobacterium chelonae (2/17), Mycobacterium mucogenicum (1/17), and Mycobacterium avium (1/17). The propensity of Mycobacterium avium hospital isolate H87 and M...
  90. Steed K, Falkinham J. Effect of growth in biofilms on chlorine susceptibility of Mycobacterium avium and Mycobacterium intracellulare. Appl Environ Microbiol. 2006;72:4007-11 pubmed
    b>Mycobacterium avium and Mycobacterium intracellulare were grown in suspension and in biofilms, and their susceptibilities to chlorine were measured. M. avium and M...
  91. Nishiuchi Y, Maekura R, Kitada S, Tamaru A, Taguri T, Kira Y, et al. The recovery of Mycobacterium avium-intracellulare complex (MAC) from the residential bathrooms of patients with pulmonary MAC. Clin Infect Dis. 2007;45:347-51 pubmed
    The distribution of Mycobacterium avium-intracellulare complex (MAC) in residences was examined. MAC was only recovered from bathrooms but not from other sites of residences...
  92. Marce C, Beaudeau F, Bareille N, Seegers H, Fourichon C. Higher non-return rate associated with Mycobacterium avium subspecies paratuberculosis infection at early stage in Holstein dairy cows. Theriogenology. 2009;71:807-16 pubmed publisher
    The effects of infection by Mycobacterium avium paratuberculosis (Map) on dairy cows are poorly documented and quite controversial...