streptomyces griseus

Summary

Summary: An actinomycete from which the antibiotics STREPTOMYCIN, grisein, and CANDICIDIN are obtained.

Top Publications

  1. Hirano S, Kato J, Ohnishi Y, Horinouchi S. Control of the Streptomyces Subtilisin inhibitor gene by AdpA in the A-factor regulatory cascade in Streptomyces griseus. J Bacteriol. 2006;188:6207-16 pubmed
    AdpA in the A-factor regulatory cascade in Streptomyces griseus activates a number of genes required for secondary metabolism and morphological differentiation, forming an AdpA regulon...
  2. Onaka H, Ando N, Nihira T, Yamada Y, Beppu T, Horinouchi S. Cloning and characterization of the A-factor receptor gene from Streptomyces griseus. J Bacteriol. 1995;177:6083-92 pubmed
    ..receptor protein control streptomycin production, streptomycin resistance, and aerial mycelium formation in Streptomyces griseus. The A-factor receptor protein (ArpA) was purified from a cell lysate of S. griseus IFO 13350...
  3. Hara H, Ohnishi Y, Horinouchi S. DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus. Microbiology. 2009;155:2197-210 pubmed publisher
    ..is a microbial hormone that triggers morphological differentiation and secondary metabolism in Streptomyces griseus. The effects of A-factor on global gene expression were determined by DNA microarray analysis of ..
  4. Marushima K, Ohnishi Y, Horinouchi S. CebR as a master regulator for cellulose/cellooligosaccharide catabolism affects morphological development in Streptomyces griseus. J Bacteriol. 2009;191:5930-40 pubmed publisher
    b>Streptomyces griseus mutants exhibiting deficient glucose repression of beta-galactosidase activity on lactose-containing minimal medium supplemented with a high concentration of glucose were isolated...
  5. Komatsu M, Kuwahara Y, Hiroishi A, Hosono K, Beppu T, Ueda K. Cloning of the conserved regulatory operon by its aerial mycelium-inducing activity in an amfR mutant of Streptomyces griseus. Gene. 2003;306:79-89 pubmed
    ..8 kb DNA fragment that suppressed the aerial mycelium-deficient phenotype of an amfR mutant of Streptomyces griseus when it was introduced on a high-copy-number plasmid...
  6. Lee H, Ohnishi Y, Horinouchi S. A sigmaB-like factor responsible for carotenoid biosynthesis in Streptomyces griseus. J Mol Microbiol Biotechnol. 2001;3:95-101 pubmed
    Self-cloning experiments with a high-copy-number plasmid and Streptomyces griseus IFO13350 led to the cloning of a 11-kb DNA fragment that conferred yellow pigment production on the host...
  7. Akanuma G, Hara H, Ohnishi Y, Horinouchi S. Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA in Streptomyces griseus. Mol Microbiol. 2009;73:898-912 pubmed publisher
    In Streptomyces griseus, A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) triggers morphological development and secondary metabolism by inducing a pleiotropic transcriptional regulator AdpA...
  8. Dharmatilake A, Kendrick K. Expression of the division-controlling gene ftsZ during growth and sporulation of the filamentous bacterium Streptomyces griseus. Gene. 1994;147:21-8 pubmed
    ..the role of cell septation events in the Streptomyces life cycle, we have isolated the ftsZ locus from Streptomyces griseus, an organism that undergoes sporulation on solid surfaces and in liquid culture...
  9. Ochi K. Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A factor. J Bacteriol. 1987;169:3608-16 pubmed
    ..the coordinated decrease in the GTP pool for initiating morphological and physiological differentiation of Streptomyces griseus, a streptomycin-producing strain...

More Information

Publications75

  1. Read R. Pushing the boundaries of molecular replacement with maximum likelihood. Acta Crystallogr D Biol Crystallogr. 2001;57:1373-82 pubmed
    ..Tests in a new molecular-replacement program, Beast, show that the likelihood-based targets are more sensitive and more accurate than previous targets. The new multiple-model likelihood function has a dramatic impact on success. ..
  2. Hirano S, Tanaka K, Ohnishi Y, Horinouchi S. Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus. Microbiology. 2008;154:905-14 pubmed publisher
    ..encoding the pathway-specific transcriptional activator of the streptomycin biosynthetic gene cluster in Streptomyces griseus [Uguru et al. (2005) Mol Microbiol 58, 131-150]. The atrA orthologue (atrA-g) in S...
  3. Gilboa R, Greenblatt H, Perach M, Spungin Bialik A, Lessel U, Wohlfahrt G, et al. Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution. Acta Crystallogr D Biol Crystallogr. 2000;56:551-8 pubmed
    SGAP is an aminopeptidase present in the extracellular fluid of Streptomyces griseus cultures. It is a double-zinc enzyme with a strong preference for large hydrophobic amino-terminus residues...
  4. Guo Y, Zheng W, Rong X, Huang Y. A multilocus phylogeny of the Streptomyces griseus 16S rRNA gene clade: use of multilocus sequence analysis for streptomycete systematics. Int J Syst Evol Microbiol. 2008;58:149-59 pubmed publisher
    ..In particular, the Streptomyces griseus 16S rRNA gene clade is the most challenging and least defined group within the genus Streptomyces in terms ..
  5. Funabashi M, Nonaka K, Yada C, Hosobuchi M, Masuda N, Shibata T, et al. Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196. J Antibiot (Tokyo). 2009;62:325-32 pubmed publisher
    A-500359s, produced by Streptomyces griseus SANK60196, are inhibitors of bacterial phospho-N-acetylmuramyl-pentapeptide translocase...
  6. Kezuka Y, Ohishi M, Itoh Y, Watanabe J, Mitsutomi M, Watanabe T, et al. Structural studies of a two-domain chitinase from Streptomyces griseus HUT6037. J Mol Biol. 2006;358:472-84 pubmed
    Chitinase C (ChiC) from Streptomyces griseus HUT6037 was the first glycoside hydrolase family 19 chitinase that was found in an organism other than higher plants...
  7. Menéndez N, Nur E Alam M, Fischer C, Brana A, Salas J, Rohr J, et al. Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity. Appl Environ Microbiol. 2006;72:167-77 pubmed
    Chromomycin A3 is an antitumor drug produced by Streptomyces griseus subsp. griseus...
  8. Menéndez N, Nur E Alam M, Brana A, Rohr J, Salas J, Mendez C. Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus. Mol Microbiol. 2004;53:903-15 pubmed
    ..It would convert a molecule with low biological activity into an active one, in a reaction catalysed by an enzyme that is predicted to be located in the cell membrane...
  9. Tezuka T, Ohnishi Y. Two glycine riboswitches activate the glycine cleavage system essential for glycine detoxification in Streptomyces griseus. J Bacteriol. 2014;196:1369-76 pubmed publisher
    ..b>Streptomyces griseus contains gcvP and the gcvT-gcvH operon, which encode three intrinsic components of the GCV system...
  10. Takano H, Hosono K, Beppu T, Ueda K. Involvement of sigma(H) and related sigma factors in glucose-dependent initiation of morphological and physiological development of Streptomyces griseus. Gene. 2003;320:127-35 pubmed
    We cloned and characterized sigH encoding a stress-response sigma factor, sigma(H), of Streptomyces griseus. Nucleotide sequencing of the sigH gene cluster revealed an identical gene organization as in the orthologous region of ..
  11. Yamazaki H, Tomono A, Ohnishi Y, Horinouchi S. DNA-binding specificity of AdpA, a transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus. Mol Microbiol. 2004;53:555-72 pubmed publisher
    ..transcriptional activator for a number of genes of various functions in the A-factor regulatory cascade in Streptomyces griseus. It consists of a ThiJ/PfpI/DJ-1-like dimerization domain at its N-terminal portion and a DNA-binding ..
  12. Funa N, Funabashi M, Ohnishi Y, Horinouchi S. Biosynthesis of hexahydroxyperylenequinone melanin via oxidative aryl coupling by cytochrome P-450 in Streptomyces griseus. J Bacteriol. 2005;187:8149-55 pubmed
    ..pathway involving a type III polyketide synthase (PKS), RppA, and a cytochrome P-450 enzyme, P-450mel, in Streptomyces griseus. In vitro reconstitution of the P-450mel catalyst with spinach ferredoxin-NADP(+) reductase/ferredoxin ..
  13. Ohnishi Y, Ishikawa J, Hara H, Suzuki H, Ikenoya M, Ikeda H, et al. Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350. J Bacteriol. 2008;190:4050-60 pubmed publisher
    We determined the complete genome sequence of Streptomyces griseus IFO 13350, a soil bacterium producing an antituberculosis agent, streptomycin, which is the first aminoglycoside antibiotic, discovered more than 60 years ago...
  14. Otani H, Higo A, Nanamiya H, Horinouchi S, Ohnishi Y. An alternative sigma factor governs the principal sigma factor in Streptomyces griseus. Mol Microbiol. 2013;87:1223-36 pubmed publisher
    ..The filamentous bacterium Streptomyces griseus has 52 sigma factors, including one essential 'principal' sigma factor (?(HrdB) ) that is responsible for ..
  15. Jiang H, Kendrick K. Characterization of ssfR and ssgA, two genes involved in sporulation of Streptomyces griseus. J Bacteriol. 2000;182:5521-9 pubmed
    In the presence of cefoxitin, which inhibits septum formation during sporulation, Streptomyces griseus is unable to sporulate, retaining the sonication sensitivity of nonsporulating hyphae...
  16. Ohnishi Y, Kameyama S, Onaka H, Horinouchi S. The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A-factor receptor. Mol Microbiol. 1999;34:102-11 pubmed
    In Streptomyces griseus, A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) at an extremely low concentration triggers streptomycin biosynthesis and cell differentiation by binding a repressor-type receptor protein (ArpA) and ..
  17. Seo J, Ohnishi Y, Hirata A, Horinouchi S. ATP-binding cassette transport system involved in regulation of morphological differentiation in response to glucose in Streptomyces griseus. J Bacteriol. 2002;184:91-103 pubmed
    b>Streptomyces griseus NP4, which was derived by UV mutagenesis from strain IFO13350, showed a bald and wrinkled colony morphology in response to glucose...
  18. Wendt Pienkowski E, Huang Y, Zhang J, Li B, Jiang H, Kwon H, et al. Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. J Am Chem Soc. 2005;127:16442-52 pubmed publisher
    ..The fdm gene cluster was localized to 33-kb DNA segment of Streptomyces griseus ATCC 49344, and its involvement in FDM A biosynthesis was proven by gene inactivation, complementation, and ..
  19. Guan S, Sattler I, Lin W, Guo D, Grabley S. p-Aminoacetophenonic acids produced by a mangrove endophyte: Streptomyces griseus subsp. J Nat Prod. 2005;68:1198-200 pubmed
    ..The structures of 1-3 were elucidated using spectroscopic analyses, primarily NMR and MS...
  20. Kato J, Chi W, Ohnishi Y, Hong S, Horinouchi S. Transcriptional control by A-factor of two trypsin genes in Streptomyces griseus. J Bacteriol. 2005;187:286-95 pubmed
    ..transcriptional activator for a number of genes of various functions in the A-factor regulatory cascade in Streptomyces griseus, forming an AdpA regulon...
  21. Völler G, Krawczyk J, Pesic A, Krawczyk B, Nachtigall J, Sussmuth R. Characterization of new class III lantibiotics--erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing. Chembiochem. 2012;13:1174-83 pubmed publisher
    ..and Griseopeptin (Gri) from Streptomyces avermitilis DSM 46492, Saccharopolyspora erythraea NRRL 2338, and Streptomyces griseus DSM 40236, respectively...
  22. Kato J, Miyahisa I, Mashiko M, Ohnishi Y, Horinouchi S. A single target is sufficient to account for the biological effects of the A-factor receptor protein of Streptomyces griseus. J Bacteriol. 2004;186:2206-11 pubmed
    In the model of the A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) regulatory cascade in Streptomyces griseus, A-factor binds ArpA, the A-factor receptor protein, that has bound to the adpA promoter and dissociates it from ..
  23. Antony Babu S, Stach J, Goodfellow M. Genetic and phenotypic evidence for Streptomyces griseus ecovars isolated from a beach and dune sand system. Antonie Van Leeuwenhoek. 2008;94:63-74 pubmed publisher
    ..six strains shared >99% 16S rRNA gene similarities with one another and with representative strains of Streptomyces griseus. Infraspecific diversity amongst the strains was investigated by multilocus sequence typing (MLST) in ..
  24. Yao M, Ohtsuka J, Nagata K, Miyazono K, Zhi Y, Ohnishi Y, et al. Complex structure of the DNA-binding domain of AdpA, the global transcription factor in Streptomyces griseus, and a target duplex DNA reveals the structural basis of its tolerant DNA sequence specificity. J Biol Chem. 2013;288:31019-29 pubmed publisher
    ..controlling the secondary metabolism and morphological differentiation of the filamentous bacterium Streptomyces griseus. AdpA binds to over 500 operator regions with the consensus sequence 5'-TGGCSNGWWY-3' (where S is G or C, W ..
  25. Takano H, Asano K, Beppu T, Ueda K. Role of sigmaH paralogs in intracellular melanin formation and spore development in Streptomyces griseus. Gene. 2007;393:43-52 pubmed
    b>Streptomyces griseus possesses multiple stress-response sigma factors including sigma(H). Previously, we have suggested that sigma(H) and related sigma factors are involved in the developmental control of S. griseus...
  26. Suzuki H, Ohnishi Y, Horinouchi S. Arylamine N-acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus. J Bacteriol. 2007;189:2155-9 pubmed publisher
    ..N-acetyltransferase (NAT) responsible for the N acetylation of exogenous 3-amino-4-hydroxybenzoic acid in Streptomyces griseus was identified and characterized...
  27. Ngo K, Umakoshi H, Shimanouchi T, Bui H, Kuboi R. Enhanced release of chitosanase from Streptomyces griseus through direct interaction of liposome with cell membrane under heat stress. J Biosci Bioeng. 2008;106:602-5 pubmed publisher
    A direct interaction of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) liposomes with membrane of Streptomyces griseus cell under the heat stress at 41 degrees C increased the chitosanase production and release to 2...
  28. Perez M, Lombo F, Baig I, Brana A, Rohr J, Salas J, et al. Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses. Appl Environ Microbiol. 2006;72:6644-52 pubmed
    ..The constructed gene clusters may be used to increase the capabilities of microorganisms to synthesize new deoxysugars and therefore to produce new glycosylated bioactive compounds...
  29. Moura R, Martin J, Martin A, Liras P. Substrate analysis and molecular cloning of the extracellular alkaline phosphatase of Streptomyces griseus. Microbiology. 2001;147:1525-33 pubmed
    ..An AP has been purified to homogeneity from cultures of Streptomyces griseus IMRU 3570...
  30. Gilboa R, Spungin Bialik A, Wohlfahrt G, Schomburg D, Blumberg S, Shoham G. Interactions of Streptomyces griseus aminopeptidase with amino acid reaction products and their implications toward a catalytic mechanism. Proteins. 2001;44:490-504 pubmed
    b>Streptomyces griseus aminopeptidase (SGAP) is a double-zinc exopeptidase with a high preference toward large hydrophobic amino-terminus residues...
  31. Tezuka T, Hara H, Ohnishi Y, Horinouchi S. Identification and gene disruption of small noncoding RNAs in Streptomyces griseus. J Bacteriol. 2009;191:4896-904 pubmed publisher
    ..identify and characterize novel bacterial sRNAs, a gram-positive, soil-inhabiting, filamentous bacterium, Streptomyces griseus, was examined, on the assumption that Streptomyces should express sRNAs as important regulators of ..
  32. Poopal A, Laxman R. Hexavalent chromate reduction by immobilized Streptomyces griseus. Biotechnol Lett. 2008;30:1005-10 pubmed publisher
    Hexavalent chromium, which is a mutagen and carcinogen, was efficiently reduced by Streptomyces griseus. This activity was associated with the cell...
  33. Kwon H, Smith W, Scharon A, Hwang S, Kurth M, Shen B. C-O bond formation by polyketide synthases. Science. 2002;297:1327-30 pubmed
    ..Genetic and biochemical characterization of the nonactin biosynthesis gene cluster from Streptomyces griseus revealed two KSs, NonJ and NonK, that are highly homologous to known KSs but catalyze sequential ..
  34. Tanaka Y, Tokuyama S, Ochi K. Activation of secondary metabolite-biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus. J Antibiot (Tokyo). 2009;62:669-73 pubmed publisher
    Unlike other Streptomyces spp., the streptomycin producer Streptomyces griseus IFO13189 shows emergence of a small fraction of rsmG and rpsL mutants among spontaneous low- or high-level streptomycin-resistant mutants...
  35. Chen Y, Wendt Pienkowski E, Ju J, Lin S, Rajski S, Shen B. Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944. J Biol Chem. 2010;285:38853-60 pubmed publisher
    ..Analysis of the fdm cluster from Streptomyces griseus ATCC 43944, however, failed to reveal genes encoding the types of amide synthetases commonly seen in ..
  36. Ueda K, Oinuma K, Ikeda G, Hosono K, Ohnishi Y, Horinouchi S, et al. AmfS, an extracellular peptidic morphogen in Streptomyces griseus. J Bacteriol. 2002;184:1488-92 pubmed
    The amf gene cluster was previously identified as a regulator for the onset of aerial-mycelium formation in Streptomyces griseus. The nucleotide sequences of amf and its counterparts in other species revealed a conserved gene organization ..
  37. Yamazaki H, Ohnishi Y, Horinouchi S. An A-factor-dependent extracytoplasmic function sigma factor (sigma(AdsA)) that is essential for morphological development in Streptomyces griseus. J Bacteriol. 2000;182:4596-605 pubmed
    ..at an extremely low concentration triggers streptomycin production and aerial mycelium formation in Streptomyces griseus. A-factor induces the expression of an A-factor-dependent transcriptional activator, AdpA, essential for ..
  38. Shin S, Xu D, Kwon H, Suh J. S-adenosylmethionine activates adpA transcription and promotes streptomycin biosynthesis in Streptomyces griseus. FEMS Microbiol Lett. 2006;259:53-9 pubmed
    ..SAM, in a quantity as low as 10 muM, enhanced streptomycin production and adpA transcription in both Streptomyces griseus wild-type strain and mutant HO1, which displays no ArpA repression on the adpA promoter...
  39. Fundoiano Hershcovitz Y, Rabinovitch L, Langut Y, Reiland V, Shoham G, Shoham Y. Identification of the catalytic residues in the double-zinc aminopeptidase from Streptomyces griseus. FEBS Lett. 2004;571:192-6 pubmed publisher
    The aminopeptidase from Streptomyces griseus (SGAP) has been cloned and expressed in Escherichia coli. By growing the cells in the presence of 1 M sorbitol at 18 degrees C, the protein was obtained in a soluble and active form...
  40. Claesen J, Bibb M. Biosynthesis and regulation of grisemycin, a new member of the linaridin family of ribosomally synthesized peptides produced by Streptomyces griseus IFO 13350. J Bacteriol. 2011;193:2510-6 pubmed publisher
    ..and characterization of grisemycin, a linaridin produced by a previously unidentified gene cluster in Streptomyces griseus IFO 13350...
  41. Ueda K, Umeyama T, Beppu T, Horinouchi S. The aerial mycelium-defective phenotype of Streptomyces griseus resulting from A-factor deficiency is suppressed by a Ser/Thr kinase of S. coelicolor A3(2). Gene. 1996;169:91-5 pubmed
    ..is essential for aerial mycelium formation and streptomycin (Sm) production in Streptomyces griseus. A protein Ser/Thr kinase (AfsK), the product of the Streptomyces coelicolor A3(2) afsK gene, controlling ..
  42. Endo K, Hosono K, Beppu T, Ueda K. A novel extracytoplasmic phenol oxidase of Streptomyces: its possible involvement in the onset of morphogenesis. Microbiology. 2002;148:1767-76 pubmed
    ..a parallel correlation between the stimulatory effect of copper and phenol-oxidizing enzyme activities in Streptomyces griseus. Here a novel extracytoplasmic phenol oxidase (EpoA) associated with cellular development of this organism ..
  43. Endo K, Hayashi Y, Hibi T, Hosono K, Beppu T, Ueda K. Enzymological characterization of EpoA, a laccase-like phenol oxidase produced by Streptomyces griseus. J Biochem. 2003;133:671-7 pubmed
    ..the enzymological characterization of EpoA, a laccase-like extracytoplasmic phenol oxidase produced by Streptomyces griseus. EpoA was expressed and purified with an Escherichia coli host-vector system as a recombinant protein fused ..
  44. Funabashi M, Funa N, Horinouchi S. Phenolic lipids synthesized by type III polyketide synthase confer penicillin resistance on Streptomyces griseus. J Biol Chem. 2008;283:13983-91 pubmed publisher
    ..A Gram-positive, filamentous bacterium Streptomyces griseus contained an srs operon, in which srsA encoded a type III PKS, srsB encoded a methyltransferase, and srsC ..
  45. Ohnishi Y, Nishiyama Y, Sato R, Kameyama S, Horinouchi S. An oligoribonuclease gene in Streptomyces griseus. J Bacteriol. 2000;182:4647-53 pubmed
    In Streptomyces griseus, A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) serves as a microbial hormone that switches on many genes required for streptomycin production and morphological development...
  46. Andersson M, Mikkola R, Kroppenstedt R, Rainey F, Peltola J, Helin J, et al. The mitochondrial toxin produced by Streptomyces griseus strains isolated from an indoor environment is valinomycin. Appl Environ Microbiol. 1998;64:4767-73 pubmed
    ..The four strains were identified as Streptomyces griseus strains by 16S ribosomal DNA and chemotaxonomic methods. The four S...
  47. Marcos A, Guti rrez S, D ez B, Fern ndez F, Oguiza J, Mart n J. Three genes hrdB, hrdD and hrdT of Streptomyces griseus IMRU 3570, encoding sigma factor-like proteins, are differentially expressed under specific nutritional conditions. Gene. 1995;153:41-8 pubmed
    ..coli, that encode sigma factor-like proteins, have been cloned from DNA of the candicidin-producing strain Streptomyces griseus IMRU 3570. They are located in different regions of the chromosome...
  48. Truhlar S, Cunningham E, Agard D. The folding landscape of Streptomyces griseus protease B reveals the energetic costs and benefits associated with evolving kinetic stability. Protein Sci. 2004;13:381-90 pubmed
    Like most extracellular bacterial proteases, Streptomyces griseus protease B (SGPB) and alpha-lytic protease (alphaLP) are synthesized with covalently attached pro regions necessary for their folding...
  49. Hong B, Phornphisutthimas S, Tilley E, Baumberg S, McDowall K. Streptomycin production by Streptomyces griseus can be modulated by a mechanism not associated with change in the adpA component of the A-factor cascade. Biotechnol Lett. 2007;29:57-64 pubmed
    ..griseus. The potential biotechnological application of our findings is discussed...
  50. Kim B, Andersen C, Benz R. Identification of a cell wall channel of Streptomyces griseus: the channel contains a binding site for streptomycin. Mol Microbiol. 2001;41:665-73 pubmed
    Cells of the Gram-positive actinomycete Streptomyces griseus were disrupted and the cell envelope was subjected to sucrose step-gradient centrifugation...
  51. Ueda K, Takano H, Nishimoto M, Inaba H, Beppu T. Dual transcriptional control of amfTSBA, which regulates the onset of cellular differentiation in Streptomyces griseus. J Bacteriol. 2005;187:135-42 pubmed
    ..a probable secretion system for a peptidic morphogen, AmfS, which induces aerial mycelium formation in Streptomyces griseus. Here we examined the transcriptional control mechanism for the promoter preceding amfT (PamfT) directing ..
  52. Uguru G, Stephens K, Stead J, Towle J, Baumberg S, McDowall K. Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor. Mol Microbiol. 2005;58:131-50 pubmed
    ..transcriptional activator unrelated to actII-ORF4 that is the final regulator of streptomycin production in Streptomyces griseus. These findings provide further evidence that the path leading to the expression of pathway-specific ..
  53. Suzuki H, Marushima K, Ohnishi Y, Horinouchi S. A novel pair of terminal protein and telomere-associated protein for replication of the linear chromosome of Streptomyces griseus IFO13350. Biosci Biotechnol Biochem. 2008;72:2973-80 pubmed
    The linear chromosome of Streptomyces griseus IFO13350 contains not only atypical telomere sequences but also probable pseudogenes for two typical telomeric proteins...
  54. Menéndez N, Nur E Alam M, Brana A, Rohr J, Salas J, Mendez C. Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. Chem Biol. 2004;11:21-32 pubmed
    ..A pathway for the biosynthesis of chromomycin A3 and its deoxysugars is proposed...
  55. Higo A, Horinouchi S, Ohnishi Y. Strict regulation of morphological differentiation and secondary metabolism by a positive feedback loop between two global regulators AdpA and BldA in Streptomyces griseus. Mol Microbiol. 2011;81:1607-22 pubmed publisher
    ..A-factor and activates many genes required for morphological differentiation and secondary metabolism in Streptomyces griseus. We confirmed that the regulatory tRNA gene bldA was required for translation of TTA-containing adpA...
  56. Chi W, Song J, Oh E, Park S, Chang Y, Kim E, et al. Medium optimization and application of an affinity column chromatography for streptomyces griseus trypsin production from the recombinant Streptomyces griseus. J Microbiol Biotechnol. 2009;19:1191-6 pubmed
    The expression vector pWHM3-TR1R2, which contains sprT encoding Streptomyces griseus trypsin (SGT) and two positive regulatory genes (sgtR1 and sgtR2), was introduced into S...
  57. Kawamoto S, Zhang D, Ochi K. Molecular analysis of the ribosomal L11 protein gene (rplK = relC) of Streptomyces griseus and identification of a deletion allele. Mol Gen Genet. 1997;255:549-60 pubmed
    The rplK (= relC) gene, which codes for ribosomal protein L11, was cloned from Streptomyces griseus IFO13189 using a screening procedure based on polymerase chain reaction amplification of a gene segment that subsequently allowed the ..
  58. Guan S, Grabley S, Groth I, Lin W, Christner A, Guo D, et al. Structure determination of germacrane-type sesquiterpene alcohols from an endophyte Streptomyces griseus subsp. Magn Reson Chem. 2005;43:1028-31 pubmed
    ..Among them, 2 and 3 are identified as new compounds...
  59. Hershcovitz Y, Gilboa R, Reiland V, Shoham G, Shoham Y. Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus. FEBS J. 2007;274:3864-76 pubmed publisher
    The catalytic mechanism underlying the aminopeptidase from Streptomyces griseus (SGAP) was investigated. pH-dependent activity profiles revealed the enthalpy of ionization for the hydrolysis of leucine-para-nitroanilide by SGAP...
  60. Rong X, Huang Y. Taxonomic evaluation of the Streptomyces griseus clade using multilocus sequence analysis and DNA-DNA hybridization, with proposal to combine 29 species and three subspecies as 11 genomic species. Int J Syst Evol Microbiol. 2010;60:696-703 pubmed publisher
    b>Streptomyces griseus and related species form the biggest but least well-defined clade in the whole Streptomyces 16S rRNA gene tree. Multilocus sequence analysis (MLSA) has shown promising potential for refining Streptomyces systematics...
  61. Campelo A, Gil J. The candicidin gene cluster from Streptomyces griseus IMRU 3570. Microbiology. 2002;148:51-9 pubmed
    A 205 kb DNA region from Streptomyces griseus IMRU 3570, including the candicidin biosynthetic gene cluster, was cloned and partially sequenced...
  62. Kwak J, Jiang H, Kendrick K. Transformation using in vivo and in vitro methylation in Streptomyces griseus. FEMS Microbiol Lett. 2002;209:243-8 pubmed
    b>Streptomyces griseus does not readily take up foreign DNA isolated from other Streptomyces species or Escherichia coli, presumably due to its unique restriction-modification systems that function as a barrier for interspecific DNA ..
  63. Poopal A, Laxman R. Studies on biological reduction of chromate by Streptomyces griseus. J Hazard Mater. 2009;169:539-45 pubmed publisher
    ..tested for chromate reduction, thirteen strains reduced Cr(VI) to Cr(III), of which one strain of Streptomyces griseus (NCIM 2020) was most efficient showing complete reduction within 24h...
  64. Itoh Y, Watanabe J, Fukada H, Mizuno R, Kezuka Y, Nonaka T, et al. Importance of Trp59 and Trp60 in chitin-binding, hydrolytic, and antifungal activities of Streptomyces griseus chitinase C. Appl Microbiol Biotechnol. 2006;72:1176-84 pubmed
    The chitin-binding domain of Streptomyces griseus chitinase C (ChBD(ChiC)) belongs to CBM family 5...
  65. Kim J, Kang S, Lee J. The protein complex composed of nickel-binding SrnQ and DNA binding motif-bearing SrnR of Streptomyces griseus represses sodF transcription in the presence of nickel. J Biol Chem. 2003;278:18455-63 pubmed
    ..transcriptional repression of sodF, which codes for iron- and zinc-containing superoxide dismutase of Streptomyces griseus, was mediated through an operator (-2 to +15) spanning over the 5' end (+1) of the transcript...
  66. Itoh Y, Kawase T, Nikaidou N, Fukada H, Mitsutomi M, Watanabe T, et al. Functional analysis of the chitin-binding domain of a family 19 chitinase from Streptomyces griseus HUT6037: substrate-binding affinity and cis-dominant increase of antifungal function. Biosci Biotechnol Biochem. 2002;66:1084-92 pubmed
    Chitinase C (ChiC) is the first bacterial family 19 chitinase discovered in Streptomyces griseus HUT6037...