clostridium perfringens

Summary

Summary: The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.

Top Publications

  1. Morrison J, Wright C, John G. Identification, Isolation and characterization of a novel azoreductase from Clostridium perfringens. Anaerobe. 2012;18:229-34 pubmed publisher
    ..In this study, the azoreductase gene was identified in Clostridium perfringens, a pathogen that is commonly found in the human intestinal tract. C...
  2. Hiscox T, Harrison P, Chakravorty A, Choo J, Ohtani K, Shimizu T, et al. Regulation of sialidase production in Clostridium perfringens by the orphan sensor histidine kinase ReeS. PLoS ONE. 2013;8:e73525 pubmed publisher
    b>Clostridium perfringens is ubiquitous in nature and is often found as a commensal of the human and animal gastrointestinal tract...
  3. Bokori Brown M, Kokkinidou M, Savva C, Fernandes da Costa S, Naylor C, Cole A, et al. Clostridium perfringens epsilon toxin H149A mutant as a platform for receptor binding studies. Protein Sci. 2013;22:650-9 pubmed publisher
    b>Clostridium perfringens epsilon toxin (Etx) is a pore-forming toxin responsible for a severe and rapidly fatal enterotoxemia of ruminants. The toxin is classified as a category B bioterrorism agent by the U.S...
  4. Schoster A, Arroyo L, Staempfli H, Shewen P, Weese J. Presence and molecular characterization of Clostridium difficile and Clostridium perfringens in intestinal compartments of healthy horses. BMC Vet Res. 2012;8:94 pubmed publisher
    Clostridium difficile and Clostridium perfringens are commonly associated with colitis in equids, but healthy carriers exist. Scarce information is available on the prevalence of Clostridium spp...
  5. Seal B. Characterization of bacteriophages virulent for Clostridium perfringens and identification of phage lytic enzymes as alternatives to antibiotics for potential control of the bacterium. Poult Sci. 2013;92:526-33 pubmed publisher
    ..b>Clostridium perfringens is a gram-positive, spore-forming anaerobic bacterium that plays a significant role in human foodborne ..
  6. Kitadokoro K, Nishimura K, Kamitani S, Fukui Miyazaki A, Toshima H, Abe H, et al. Crystal structure of Clostridium perfringens enterotoxin displays features of beta-pore-forming toxins. J Biol Chem. 2011;286:19549-55 pubmed publisher
    b>Clostridium perfringens enterotoxin (CPE) is a cause of food poisoning and is considered a pore-forming toxin, which damages target cells by disrupting the selective permeability of the plasma membrane...
  7. Redondo L, Farber M, Venzano A, Jost B, Parma Y, Fernandez Miyakawa M. Sudden death syndrome in adult cows associated with Clostridium perfringens type E. Anaerobe. 2013;20:1-4 pubmed publisher
    b>Clostridium perfringens type E is considered a rare toxinotype and an infrequent cause of enterotoxemia of lambs, calves, and rabbits. Until now, only cases of young animal of C...
  8. Li J, Sayeed S, Robertson S, Chen J, McClane B. Sialidases affect the host cell adherence and epsilon toxin-induced cytotoxicity of Clostridium perfringens type D strain CN3718. PLoS Pathog. 2011;7:e1002429 pubmed publisher
    b>Clostridium perfringens type B or D isolates, which cause enterotoxemias or enteritis in livestock, produce epsilon toxin (ETX). ETX is exceptionally potent, earning it a listing as a CDC class B select toxin. Most C...
  9. Briggs D, Naylor C, Smedley J, Lukoyanova N, Robertson S, Moss D, et al. Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins. J Mol Biol. 2011;413:138-49 pubmed publisher
    b>Clostridium perfringens enterotoxin (CPE) is a major cause of food poisoning and antibiotic-associated diarrhea. Upon its release from C...

More Information

Publications98

  1. Li J, Miyamoto K, Sayeed S, McClane B. Organization of the cpe locus in CPE-positive clostridium perfringens type C and D isolates. PLoS ONE. 2010;5:e10932 pubmed publisher
    b>Clostridium perfringens enterotoxin (encoded by the cpe gene) contributes to several important human, and possibly veterinary, enteric diseases...
  2. Obana N, Shirahama Y, Abe K, Nakamura K. Stabilization of Clostridium perfringens collagenase mRNA by VR-RNA-dependent cleavage in 5' leader sequence. Mol Microbiol. 2010;77:1416-28 pubmed publisher
    ..regulates many genes including toxin genes such as collagenase (colA) and phospholipase C (plc) in Clostridium perfringens. Although the VR-RNA 3' region is sufficient to regulate the colA and plc genes, the molecular mechanism ..
  3. Gharaibeh S, Al Rifai R, Al Majali A. Molecular typing and antimicrobial susceptibility of Clostridium perfringens from broiler chickens. Anaerobe. 2010;16:586-9 pubmed publisher
    b>Clostridium perfringens (Cp) causes necrotic enteritis disease in commercial poultry. Antimicrobials are used to control and treat this disease and sometimes clinical outbreaks do not respond well to certain treatments...
  4. Mathur D, Deshmukh S, Kaushik H, Garg L. Functional and structural characterization of soluble recombinant epsilon toxin of Clostridium perfringens D, causative agent of enterotoxaemia. Appl Microbiol Biotechnol. 2010;88:877-84 pubmed publisher
    b>Clostridium perfringens types B and D are responsible for enterotoxaemia, one of the major causes of cattle mortality and is therefore of great economic concern...
  5. Nariya H, Miyata S, Tamai E, Sekiya H, Maki J, Okabe A. Identification and characterization of a putative endolysin encoded by episomal phage phiSM101 of Clostridium perfringens. Appl Microbiol Biotechnol. 2011;90:1973-9 pubmed publisher
    b>Clostridium perfringens produces potent toxins and histolytic enzymes, causing various diseases including life-threatening fulminant diseases in humans and other animals...
  6. Valgaeren B, Pardon B, Verherstraeten S, Goossens E, Timbermont L, Haesebrouck F, et al. Intestinal clostridial counts have no diagnostic value in the diagnosis of enterotoxaemia in veal calves. Vet Rec. 2013;172:237 pubmed publisher
    ..This study aimed to evaluate intestinal Clostridium perfringens counts as a diagnostic tool for enterotoxaemia...
  7. Martin T, Smyth J. The ability of disease and non-disease producing strains of Clostridium perfringens from chickens to adhere to extracellular matrix molecules and Caco-2 cells. Anaerobe. 2010;16:533-9 pubmed publisher
    b>Clostridium perfringens is a major enteric pathogen that is responsible for causing necrotic enteritis of poultry...
  8. Cheung J, Keyburn A, Carter G, Lanckriet A, Van Immerseel F, Moore R, et al. The VirSR two-component signal transduction system regulates NetB toxin production in Clostridium perfringens. Infect Immun. 2010;78:3064-72 pubmed publisher
    b>Clostridium perfringens causes several diseases in domestic livestock, including necrotic enteritis in chickens, which is of concern to the poultry industry due to its health implications and associated economic cost...
  9. Mueller Spitz S, Stewart L, Klump J, McLellan S. Freshwater suspended sediments and sewage are reservoirs for enterotoxin-positive Clostridium perfringens. Appl Environ Microbiol. 2010;76:5556-62 pubmed publisher
    ..b>Clostridium perfringens is a commonly used fecal indicator that represents a human pathogen...
  10. Rajendran G, Bothma P, Brodbeck A. Intravascular haemolysis and septicaemia due to Clostridium perfringens liver abscess. Anaesth Intensive Care. 2010;38:942-5 pubmed
    Intravascular haemolysis is a rare but serious complication of Clostridium perfringens sepsis. The outcome is usually fatal unless treatment is started early...
  11. Scallan E, Hoekstra R, Angulo F, Tauxe R, Widdowson M, Roy S, et al. Foodborne illness acquired in the United States--major pathogens. Emerg Infect Dis. 2011;17:7-15 pubmed publisher
    ..Most (58%) illnesses were caused by norovirus, followed by nontyphoidal Salmonella spp. (11%), Clostridium perfringens (10%), and Campylobacter spp. (9%). Leading causes of hospitalization were nontyphoidal Salmonella spp...
  12. Oda M, Kabura M, Takagishi T, Suzue A, Tominaga K, Urano S, et al. Clostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex. J Biol Chem. 2012;287:33070-9 pubmed
    b>Clostridium perfringens alpha-toxin is the major virulence factor in the pathogenesis of gas gangrene...
  13. Nagahama M, Umezaki M, Tashiro R, Oda M, Kobayashi K, Shibutani M, et al. Intracellular trafficking of Clostridium perfringens iota-toxin b. Infect Immun. 2012;80:3410-6 pubmed publisher
    b>Clostridium perfringens iota-toxin is composed of an enzymatic component (Ia) and a binding component (Ib). Ib binds to a cell surface receptor, undergoes oligomerization in lipid rafts, and binds Ia...
  14. Wu S, Rodgers N, Choct M. Real-time PCR assay for Clostridium perfringens in broiler chickens in a challenge model of necrotic enteritis. Appl Environ Microbiol. 2011;77:1135-9 pubmed publisher
    We compared ileal Clostridium perfringens quantification results produced by real-time PCR and culture-based methods in broiler chickens in a challenge model of necrotic enteritis...
  15. Coursodon C, Glock R, Moore K, Cooper K, Songer J. TpeL-producing strains of Clostridium perfringens type A are highly virulent for broiler chicks. Anaerobe. 2012;18:117-21 pubmed publisher
    b>Clostridium perfringens type A and type C are causative agents of necrotic enteritis (NE) in poultry. TpeL, a recently-described novel member of the family of large clostridial cytotoxins, was found in C. perfringens type C...
  16. Kim H, Byun J, Roh I, Bae Y, Lee M, Kim B, et al. First isolation of Clostridium perfringens type E from a goat with diarrhea. Anaerobe. 2013;22:141-3 pubmed publisher
    ..Heavy growth of only Clostridium perfringens type E, and no detection of the other enteric pathogens in the small intestine, suggests that C...
  17. de Oliveira T, de Araújo Soares R, Ramos E, das Graças Cardoso M, Alves E, Piccoli R. Antimicrobial activity of Satureja montana L. essential oil against Clostridium perfringens type A inoculated in mortadella-type sausages formulated with different levels of sodium nitrite. Int J Food Microbiol. 2011;144:546-55 pubmed publisher
    ..essential oil (EO) against Clostridium perfringens type A (ATCC 3624) inoculated in mortadella-type sausages formulated with different levels of sodium ..
  18. Yan X, Porter C, Hardy S, Steer D, Smith A, Quinsey N, et al. Structural and functional analysis of the pore-forming toxin NetB from Clostridium perfringens. MBio. 2013;4:e00019-13 pubmed publisher
    b>Clostridium perfringens is an anaerobic bacterium that causes numerous important human and animal diseases, primarily as a result of its ability to produce many different protein toxins. In chickens, C...
  19. Lee K, Lillehoj H, Li G, Park M, Jang S, Jeong W, et al. Identification and cloning of two immunogenic Clostridium perfringens proteins, elongation factor Tu (EF-Tu) and pyruvate:ferredoxin oxidoreductase (PFO) of C. perfringens. Res Vet Sci. 2011;91:e80-6 pubmed publisher
    ..Two antigenic Clostridium perfringens proteins, elongation factor Tu (EF-Tu) and pyruvate:ferredoxin oxidoreductase (PFO), were identified by ..
  20. Crost E, Ajandouz E, Villard C, Geraert P, Puigserver A, Fons M. Ruminococcin C, a new anti-Clostridium perfringens bacteriocin produced in the gut by the commensal bacterium Ruminococcus gnavus E1. Biochimie. 2011;93:1487-94 pubmed publisher
    ..rats, Ruminococcus gnavus E1 - a bacterium isolated from human faeces - produced a trypsin-dependent anti-Clostridium perfringens substance collectively named Ruminococcin C (RumC)...
  21. Jozefiak D, Sip A, Rutkowski A, Rawski M, Kaczmarek S, Wołuń Cholewa M, et al. Lyophilized Carnobacterium divergens AS7 bacteriocin preparation improves performance of broiler chickens challenged with Clostridium perfringens. Poult Sci. 2012;91:1899-907 pubmed publisher
    ..selected microbial populations, and histomorphology in broiler chickens challenged with a mixture of 3 Clostridium perfringens isolates...
  22. Verherstraeten S, Goossens E, Valgaeren B, Pardon B, Timbermont L, Vermeulen K, et al. The synergistic necrohemorrhagic action of Clostridium perfringens perfringolysin and alpha toxin in the bovine intestine and against bovine endothelial cells. Vet Res. 2013;44:45 pubmed publisher
    Bovine necrohemorrhagic enteritis is a major cause of mortality in veal calves. Clostridium perfringens is considered as the causative agent, but there has been controversy on the toxins responsible for the disease...
  23. Zeng J, Deng G, Wang J, Zhou J, Liu X, Xie Q, et al. Potential protective immunogenicity of recombinant Clostridium perfringens ?-?2-?1 fusion toxin in mice, sows and cows. Vaccine. 2011;29:5459-66 pubmed publisher
    Clostridial toxins are main pathogenic virulence of Clostridium perfringens that have been associated with a wide range of diseases in both humans and domestic animals...
  24. Gil de Los Santos J, Storch O, Fernandes C, Gil Turnes C. Evaluation in broilers of the probiotic properties of Pichia pastoris and a recombinant P. pastoris containing the Clostridium perfringens alpha toxin gene. Vet Microbiol. 2012;156:448-51 pubmed publisher
    The probiotic properties of Pichia pastoris and of a recombinant P. pastoris containing the Clostridium perfringens alpha toxin gene were evaluated in broilers...
  25. Porter C, Bantwal R, Bannam T, Rosado C, Pearce M, Adams V, et al. The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria. Mol Microbiol. 2012;83:275-88 pubmed publisher
    ..We investigated the mechanism of conjugation in Gram-positive pathogens using a model plasmid pCW3 from Clostridium perfringens. pCW3 encodes tetracycline resistance and contains the tcp locus, which is essential for conjugation...
  26. Lepp D, Roxas B, Parreira V, Marri P, Rosey E, Gong J, et al. Identification of novel pathogenicity loci in Clostridium perfringens strains that cause avian necrotic enteritis. PLoS ONE. 2010;5:e10795 pubmed publisher
    Type A Clostridium perfringens causes poultry necrotic enteritis (NE), an enteric disease of considerable economic importance, yet can also exist as a member of the normal intestinal microbiota...
  27. Lanckriet A, Timbermont L, Eeckhaut V, Haesebrouck F, Ducatelle R, Van Immerseel F. Variable protection after vaccination of broiler chickens against necrotic enteritis using supernatants of different Clostridium perfringens strains. Vaccine. 2010;28:5920-3 pubmed publisher
    Necrotic enteritis is an economically important disease of chickens caused by Clostridium perfringens. Immunity to necrotic enteritis is not fully characterized yet, but previous reports indicate that immunoprotective potential is ..
  28. Thanissery R, McReynolds J, Conner D, Macklin K, Curtis P, Fasina Y. Evaluation of the efficacy of yeast extract in reducing intestinal Clostridium perfringens levels in broiler chickens. Poult Sci. 2010;89:2380-8 pubmed publisher
    The etiological agent of necrotic enteritis is Clostridium perfringens. Traditionally, necrotic enteritis is controlled with in-feed antibiotics...
  29. Macias Rioseco M, Beingesser J, Uzal F. Freezing or adding trypsin inhibitor to equine intestinal contents extends the lifespan of Clostridium perfringens beta toxin for diagnostic purposes. Anaerobe. 2012;18:357-60 pubmed publisher
    b>Clostridium perfringens type C causes necrotizing enteritis mostly in neonatal animals of several species, including horses. The virulence of C. perfringens type C is mostly mediated by beta toxin (CPB)...
  30. Liu H, Bouillaut L, Sonenshein A, Melville S. Use of a mariner-based transposon mutagenesis system to isolate Clostridium perfringens mutants deficient in gliding motility. J Bacteriol. 2013;195:629-36 pubmed publisher
    b>Clostridium perfringens is an anaerobic Gram-positive pathogen that causes many human and animal diseases, including food poisoning and gas gangrene. C. perfringens lacks flagella but possesses type IV pili (TFP)...
  31. Yonogi S, Matsuda S, Kawai T, Yoda T, Harada T, Kumeda Y, et al. BEC, a novel enterotoxin of Clostridium perfringens found in human clinical isolates from acute gastroenteritis outbreaks. Infect Immun. 2014;82:2390-9 pubmed publisher
    b>Clostridium perfringens is a causative agent of food-borne gastroenteritis for which C. perfringens enterotoxin (CPE) has been considered an essential factor...
  32. Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, et al. Protein kinase C? inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4. Cell Tissue Res. 2011;346:369-81 pubmed publisher
    ..are abnormally regulated and are thus promising molecular targets for diagnosis and therapy with Clostridium perfringens enterotoxin (CPE)...
  33. Yang Z, Shim W, Kim K, Chung D. Rapid detection of enterotoxigenic Clostridium perfringens in meat samples using immunomagnetic separation polymerase chain reaction (IMS-PCR). J Agric Food Chem. 2010;58:7135-40 pubmed publisher
    Rapid detection of enterotoxigenic Clostridium perfringens in meat samples was accomplished with an immunomagnetic separation polymerase chain reaction (IMS-PCR). First, a monoclonal antibody (mAb) specific to C...
  34. Farzan A, Kircanski J, DeLay J, Soltes G, Songer J, Friendship R, et al. An investigation into the association between cpb2-encoding Clostridium perfringens type A and diarrhea in neonatal piglets. Can J Vet Res. 2013;77:45-53 pubmed
    To investigate the possible role of cpb2-positive type A Clostridium perfringens in neonatal diarrheal illness in pigs, the jejunum and colon of matched normal and diarrheic piglets from 10 farms with a history of neonatal diarrhea were ..
  35. Morris W, Dunleavy M, Diodati J, Berra G, Fernandez Miyakawa M. Effects of Clostridium perfringens alpha and epsilon toxins in the bovine gut. Anaerobe. 2012;18:143-7 pubmed publisher
    b>Clostridium perfringens alpha and epsilon toxins produce enterotoxaemia in sheep and goats. However, the information regarding the pathophysiology of alpha and epsilon toxins in the bovine intestine is still scanty...
  36. Paredes Sabja D, Sarker N, Sarker M. Clostridium perfringens tpeL is expressed during sporulation. Microb Pathog. 2011;51:384-8 pubmed publisher
    b>Clostridium perfringens TpeL belongs to the family of large clostridial toxins. Although recent studies demonstrated the expression of tpeL during vegetative growth nothing is known about tpeL expression during sporulation...
  37. Bantwal R, Bannam T, Porter C, Quinsey N, Lyras D, Adams V, et al. The peptidoglycan hydrolase TcpG is required for efficient conjugative transfer of pCW3 in Clostridium perfringens. Plasmid. 2012;67:139-47 pubmed publisher
    ..Conjugative plasmids from the Gram-positive pathogen Clostridium perfringens all encode two putative peptidoglycan hydrolases, TcpG and TcpI, within the conserved tcp transfer locus...
  38. Alnassan A, Shehata A, Kotsch M, Lendner M, Daugschies A, Bangoura B. Embryonated chicken eggs as an alternative model for mixed Clostridium perfringens and Eimeria tenella infection in chickens. Parasitol Res. 2013;112:2299-306 pubmed publisher
    ..In the present study, a new approach for testing the pathogenesis and virulence of Clostridium perfringens and Eimeria tenella dual infections as a model using the CAM of embryonated chicken eggs was developed...
  39. Valgaeren B, Pardon B, Goossens E, Verherstraeten S, Schauvliege S, Timbermont L, et al. lesion development in a new intestinal loop model indicates the involvement of a shared Clostridium perfringens virulence factor in haemorrhagic enteritis in calves. J Comp Pathol. 2013;149:103-12 pubmed publisher
    b>Clostridium perfringens-associated enterotoxaemia is a fatal disease in fast growing suckler and veal calves. An intestinal loop model was developed to study the pathogenesis of the disease...
  40. Goldstein M, Kruth S, Bersenas A, Holowaychuk M, Weese J. Detection and characterization of Clostridium perfringens in the feces of healthy and diarrheic dogs. Can J Vet Res. 2012;76:161-5 pubmed
    b>Clostridium perfringens has been implicated as a cause of diarrhea in dogs. The objectives of this study were to compare 2 culture methods and to evaluate a multiplex polymerase chain reaction (PCR) assay to detect C...
  41. Popoff M. Epsilon toxin: a fascinating pore-forming toxin. FEBS J. 2011;278:4602-15 pubmed publisher
    Epsilon toxin (ETX) is produced by strains of Clostridium perfringens classified as type B or type D...
  42. Sumners L, Cox C, Kim S, Salevsky J, Siegel P, Dalloul R. Immunological responses to Clostridium perfringens alpha-toxin in two genetically divergent lines of chickens as influenced by major histocompatibility complex genotype. Poult Sci. 2012;91:592-603 pubmed publisher
    ..Resistance to Clostridium perfringens is one instance in which the lines do not follow their established trend of pathogen susceptibility, ..
  43. Gervasi T, Curto R, Narbad A, Mayer M. Complete genome sequence of ?CP51, a temperate bacteriophage of Clostridium perfringens. Arch Virol. 2013;158:2015-7 pubmed publisher
    During sequencing of the genome of Clostridium perfringens strain 5147-97, a putative prophage was identified, located within a gene for a proposed flavodoxin oxidoreductase...
  44. Badagliacca P, Di Provvido A, Scattolini S, Pompei G, Di Giannatale E. Toxin genotyping of Clostridium perfringens strains using a polymerase chain reaction protocol. Vet Ital. 2010;46:113-8, 107-12 pubmed
    ..eta, enterotoxin and beta2 toxins, respectively, was applied to DNA extracted from two collections of Clostridium perfringens strains. The first collection involved 19 isolates from rabbits...
  45. Van Immerseel F, Pardon B, Maes S, Heyndrickx M, Timbermont L, Boyen F, et al. Isolation of a clonal population of Clostridium perfringens type A from a Belgian Blue calf with abomasal ulceration. J Comp Pathol. 2010;143:289-93 pubmed publisher
    ..b>Clostridium perfringens type A was isolated from multiple ulcers and from the intestinal contents of the animal and pulsed field ..
  46. Cocco E, Casagrande F, Bellone S, Richter C, Bellone M, Todeschini P, et al. Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer. BMC Cancer. 2010;10:349 pubmed publisher
    ..Using high-throughput technologies to analyze genetic fingerprints of ovarian cancer, we have discovered extremely high expression of the genes encoding the proteins claudin-3 and claudin-4...
  47. Obana N, Nakamura K. A novel toxin regulator, the CPE1446-CPE1447 protein heteromeric complex, controls toxin genes in Clostridium perfringens. J Bacteriol. 2011;193:4417-24 pubmed publisher
    b>Clostridium perfringens is a Gram-positive anaerobic spore-forming bacterium that is widespread in environmental soil and sewage, as well as in animal intestines...
  48. Rodgers K, Arvidson C, Melville S. Expression of a Clostridium perfringens type IV pilin by Neisseria gonorrhoeae mediates adherence to muscle cells. Infect Immun. 2011;79:3096-105 pubmed publisher
    b>Clostridium perfringens is an anaerobic, Gram-positive bacterium that causes a range of diseases in humans, including lethal gas gangrene. We have recently shown that strains of C...
  49. Miyamoto K, Yumine N, Mimura K, Nagahama M, Li J, McClane B, et al. Identification of novel Clostridium perfringens type E strains that carry an iota toxin plasmid with a functional enterotoxin gene. PLoS ONE. 2011;6:e20376 pubmed publisher
    b>Clostridium perfringens enterotoxin (CPE) is a major virulence factor for human gastrointestinal diseases, such as food poisoning and antibiotic associated diarrhea. The CPE-encoding gene (cpe) can be chromosomal or plasmid-borne...
  50. Timbermont L, Lanckriet A, Dewulf J, Nollet N, Schwarzer K, Haesebrouck F, et al. Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils. Avian Pathol. 2010;39:117-21 pubmed publisher
    ..showing that lauric acid, thymol, and cinnamaldehyde are very effective in inhibiting the growth of Clostridium perfringens. The in vivo effects were studied in two trials in an experimental necrotic enteritis model in broiler ..
  51. Wang G, Zhang P, Paredes Sabja D, Green C, Setlow P, Sarker M, et al. Analysis of the germination of individual Clostridium perfringens spores and its heterogeneity. J Appl Microbiol. 2011;111:1212-23 pubmed publisher
    To analyse the germination and its heterogeneity of individual spores of Clostridium perfringens.
  52. Nagahama M, Shibutani M, Seike S, Yonezaki M, Takagishi T, Oda M, et al. The p38 MAPK and JNK pathways protect host cells against Clostridium perfringens beta-toxin. Infect Immun. 2013;81:3703-8 pubmed publisher
    b>Clostridium perfringens beta-toxin is an important agent of necrotic enteritis and enterotoxemia. Beta-toxin is a pore-forming toxin (PFT) that causes cytotoxicity...
  53. Fernandes da Costa S, Mot D, Bokori Brown M, Savva C, Basak A, Van Immerseel F, et al. Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids. Vaccine. 2013;31:4003-8 pubmed publisher
    NetB (necrotic enteritis toxin B) is a recently identified ?-pore-forming toxin produced by Clostridium perfringens. This toxin has been shown to play a major role in avian necrotic enteritis...
  54. Fujita M, Tsuchida A, Hirata A, Kobayashi N, Goto K, Osumi K, et al. Glycoside hydrolase family 89 alpha-N-acetylglucosaminidase from Clostridium perfringens specifically acts on GlcNAc alpha1,4Gal beta1R at the non-reducing terminus of O-glycans in gastric mucin. J Biol Chem. 2011;286:6479-89 pubmed publisher
    ..Here, we reveal the substrate specificity of ?GNase (AgnC) from Clostridium perfringens strain 13, a bacterial homolog of human ?GNase, by chemically synthesizing a series of disaccharide ..
  55. Li J, Chen J, Vidal J, McClane B. The Agr-like quorum-sensing system regulates sporulation and production of enterotoxin and beta2 toxin by Clostridium perfringens type A non-food-borne human gastrointestinal disease strain F5603. Infect Immun. 2011;79:2451-9 pubmed publisher
    b>Clostridium perfringens type A strains producing enterotoxin (CPE) cause one of the most common bacterial food-borne illnesses, as well as many cases of non-food-borne human gastrointestinal disease...
  56. Vidal J, Ma M, Saputo J, Garcia J, Uzal F, McClane B. Evidence that the Agr-like quorum sensing system regulates the toxin production, cytotoxicity and pathogenicity of Clostridium perfringens type C isolate CN3685. Mol Microbiol. 2012;83:179-94 pubmed publisher
    b>Clostridium perfringens possesses at least two functional quorum sensing (QS) systems, i.e. an Agr-like system and a LuxS-dependent AI-2 system. Both of those QS systems can reportedly control in vitro toxin production by C...
  57. Bokori Brown M, Savva C, Fernandes da Costa S, Naylor C, Basak A, Titball R. Molecular basis of toxicity of Clostridium perfringens epsilon toxin. FEBS J. 2011;278:4589-601 pubmed publisher
    b>Clostridium perfringens ?-toxin is produced by toxinotypes B and D strains. The toxin is the aetiological agent of dysentery in newborn lambs but is also associated with enteritis and enterotoxaemia in goats, calves and foals...
  58. Voidarou C, Bezirtzoglou E, Alexopoulos A, Plessas S, Stefanis C, Papadopoulos I, et al. Occurrence of Clostridium perfringens from different cultivated soils. Anaerobe. 2011;17:320-4 pubmed publisher
    The occurrence of Clostridium perfringens was estimated in 750 samples originated from a variety of soils bearing various bulb crops: Brawnica oderacea (vegetable), Olea europaea, Daucus carota (carote), Solanum tuberosum (potato), ..
  59. Miyamoto K, Li J, McClane B. Enterotoxigenic Clostridium perfringens: detection and identification. Microbes Environ. 2012;27:343-9 pubmed
    Recent advances in understanding the genetics of enterotoxigenic Clostridium perfringens, including whole genome sequencing of a chromosomal cpe strain and sequencing of several cpe-carrying large plasmids, have led to the development of ..
  60. Timbermont L, Haesebrouck F, Ducatelle R, Van Immerseel F. Necrotic enteritis in broilers: an updated review on the pathogenesis. Avian Pathol. 2011;40:341-7 pubmed publisher
    b>Clostridium perfringens-induced necrotic enteritis and related subclinical disease have become economically significant problems for the broiler industry. Fortunately, scientific interest in this topic has grown: new C...
  61. Keyburn A, Bannam T, Moore R, Rood J. NetB, a pore-forming toxin from necrotic enteritis strains of Clostridium perfringens. Toxins (Basel). 2010;2:1913-27 pubmed publisher
    The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the ?-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains...
  62. Pruteanu M, Shanahan F. Digestion of epithelial tight junction proteins by the commensal Clostridium perfringens. Am J Physiol Gastrointest Liver Physiol. 2013;305:G740-8 pubmed publisher
    ..We previously reported that some components of the human commensal microbiota, particularly Clostridium perfringens (C...
  63. Chakravorty A, Awad M, Hiscox T, Cheung J, Carter G, Choo J, et al. The cysteine protease ?-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis. PLoS ONE. 2011;6:e22762 pubmed publisher
    b>Clostridium perfringens is the causative agent of clostridial myonecrosis or gas gangrene and produces many different extracellular toxins and enzymes, including the cysteine protease ?-clostripain...
  64. Ma M, Li J, McClane B. Genotypic and phenotypic characterization of Clostridium perfringens isolates from Darmbrand cases in post-World War II Germany. Infect Immun. 2012;80:4354-63 pubmed publisher
    b>Clostridium perfringens type C strains are the only non-type-A isolates that cause human disease. They are responsible for enteritis necroticans, which was termed Darmbrand when occurring in post-World War II Germany...
  65. Mot D, Timbermont L, Delezie E, Haesebrouck F, Ducatelle R, Van Immerseel F. Day-of-hatch vaccination is not protective against necrotic enteritis in broiler chickens. Avian Pathol. 2013;42:179-84 pubmed publisher
    Necrotic enteritis, caused by netB toxin-producing Clostridium perfringens type A, is an important disease in broiler chickens worldwide...
  66. Simmons M, Donovan D, Siragusa G, Seal B. Recombinant expression of two bacteriophage proteins that lyse clostridium perfringens and share identical sequences in the C-terminal cell wall binding domain of the molecules but are dissimilar in their N-terminal active domains. J Agric Food Chem. 2010;58:10330-7 pubmed publisher
    b>Clostridium perfringens is a Gram-positive anaerobic spore-forming bacterium capable of producing four major toxins that are responsible for disease symptoms and pathogenesis in a variety of animals, humans, and poultry...
  67. Lee K, Lillehoj H, Park M, Jang S, Ritter G, Hong Y, et al. Clostridium perfringens alpha-toxin and NetB toxin antibodies and their possible role in protection against necrotic enteritis and gangrenous dermatitis in broiler chickens. Avian Dis. 2012;56:230-3 pubmed
    ..Although NE and GD share a common pathogen, Clostridium perfringens, they differ in other important aspects such as clinical signs, pathologic symptoms, and age of onset...
  68. Waggett B, McGorum B, Wernery U, Shaw D, Pirie R. Prevalence of Clostridium perfringens in faeces and ileal contents from grass sickness affected horses: comparisons with 3 control populations. Equine Vet J. 2010;42:494-9 pubmed publisher
  69. Wioland L, Dupont J, Bossu J, Popoff M, Poulain B. Attack of the nervous system by Clostridium perfringens Epsilon toxin: from disease to mode of action on neural cells. Toxicon. 2013;75:122-35 pubmed publisher
    Epsilon toxin (ET), produced by Clostridium perfringens types B and D, ranks among the four most potent poisonous substances known so far. ET-intoxication is responsible for enterotoxaemia in animals, mainly sheep and goats...
  70. Garcia J, Adams V, Beingesser J, Hughes M, Poon R, Lyras D, et al. Epsilon toxin is essential for the virulence of Clostridium perfringens type D infection in sheep, goats, and mice. Infect Immun. 2013;81:2405-14 pubmed publisher
    b>Clostridium perfringens type D causes disease in sheep, goats, and other ruminants...
  71. Nowell V, Kropinski A, Songer J, MacInnes J, Parreira V, Prescott J. Genome sequencing and analysis of a type A Clostridium perfringens isolate from a case of bovine clostridial abomasitis. PLoS ONE. 2012;7:e32271 pubmed publisher
    b>Clostridium perfringens is a common inhabitant of the avian and mammalian gastrointestinal tracts and can behave commensally or pathogenically. Some enteric diseases caused by type A C...
  72. Slavić D, Boerlin P, Fabri M, Klotins K, Zoethout J, Weir P, et al. Antimicrobial susceptibility of Clostridium perfringens isolates of bovine, chicken, porcine, and turkey origin from Ontario. Can J Vet Res. 2011;75:89-97 pubmed
    Antimicrobial susceptibilities and toxin types were determined for 275 Clostridium perfringens isolates collected in Ontario in the spring of 2005. Minimal inhibitory concentrations (MICs) of C...
  73. Casagrande F, Cocco E, Bellone S, Richter C, Bellone M, Todeschini P, et al. Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in mice by intraperitoneal administration of Clostridium perfringens enterotoxin. Cancer. 2011;117:5519-28 pubmed publisher
    ..Because this tight junction protein is the natural high-affinity receptor for Clostridium perfringens enterotoxin (CPE), we have extensively investigated the sensitivity of ovarian cancer stem cells to CPE ..
  74. Hibberd M, Neumann A, Rehberger T, Siragusa G. Multilocus sequence typing subtypes of poultry Clostridium perfringens isolates demonstrate disease niche partitioning. J Clin Microbiol. 2011;49:1556-67 pubmed publisher
    b>Clostridium perfringens is a ubiquitous and versatile pathogenic bacterium and is implicated in the etiology of the poultry diseases necrotic enteritis (NE) and poultry gangrene (PG)...
  75. Ficko Blean E, Stuart C, Suits M, Cid M, Tessier M, Woods R, et al. Carbohydrate recognition by an architecturally complex ?-N-acetylglucosaminidase from Clostridium perfringens. PLoS ONE. 2012;7:e33524 pubmed publisher
    CpGH89 is a large multimodular enzyme produced by the human and animal pathogen Clostridium perfringens. The catalytic activity of this exo-?-D-N-acetylglucosaminidase is directed towards a rare carbohydrate motif, N-acetyl-?-D-..
  76. André G, Haudecoeur E, Monot M, Ohtani K, Shimizu T, Dupuy B, et al. Global regulation of gene expression in response to cysteine availability in Clostridium perfringens. BMC Microbiol. 2010;10:234 pubmed publisher
    ..In Clostridium perfringens, the two-component system, VirR/VirS, controls the expression of the ubiG operon involved in methionine ..
  77. Milach A, de Los Santos J, Turnes C, Moreira A, de Assis R, Salvarani F, et al. Production and characterization of Clostridium perfringens recombinant ? toxoid. Anaerobe. 2012;18:363-5 pubmed publisher
    In this work, we produced and evaluated a vaccine based on a ? toxoid of Clostridium perfringens type C produced in Escherichia coli (rBT)...
  78. Paredes Sabja D, Sarker M. Germination response of spores of the pathogenic bacterium Clostridium perfringens and Clostridium difficile to cultured human epithelial cells. Anaerobe. 2011;17:78-84 pubmed publisher
    Spores of pathogenic Clostridium perfringens and Clostridium difficile must germinate in the food vehicle and/or host's intestinal tract to cause disease. In this work, we examined the germination response of spores of C...
  79. Tanaka H, Nariya H, Suzuki M, Houchi H, Tamai E, Miyata S, et al. High-level production and purification of clostripain expressed in a virulence-attenuated strain of Clostridium perfringens. Protein Expr Purif. 2011;76:83-9 pubmed publisher
    ..Our expression system comprises pCLO, an rCLO expressing vector, and Clostridium perfringens 13?6, an in-frame deletion strain as to six genes encoding major virulence factors and secretory proteins...
  80. Volozhantsev N, Verevkin V, Bannov V, Krasilnikova V, Myakinina V, Zhilenkov E, et al. The genome sequence and proteome of bacteriophage ?CPV1 virulent for Clostridium perfringens. Virus Res. 2011;155:433-9 pubmed publisher
    Application of bacteriophages and their lytic enzymes to control Clostridium perfringens is one potential approach to reduce the pathogen on poultry farms and in poultry-processing facilities. Bacteriophages lytic for C...
  81. Lindstrom M, Heikinheimo A, Lahti P, Korkeala H. Novel insights into the epidemiology of Clostridium perfringens type A food poisoning. Food Microbiol. 2011;28:192-8 pubmed publisher
    b>Clostridium perfringens food poisoning ranks among the most common gastrointestinal diseases in developed countries. The disease is caused by C. perfringens enterotoxin (CPE) encoded by cpe and produced by less than 5% of C...
  82. van Bunderen C, Bomers M, Wesdorp E, Peerbooms P, Veenstra J. Clostridium perfringens septicaemia with massive intravascular haemolysis: a case report and review of the literature. Neth J Med. 2010;68:343-6 pubmed
    We describe the case of a 74-year-old man with cholangitis, complicated by Clostridium perfringens septicaemia and massive intravascular haemolysis...
  83. Robertson S, Li J, Uzal F, McClane B. Evidence for a prepore stage in the action of Clostridium perfringens epsilon toxin. PLoS ONE. 2011;6:e22053 pubmed publisher
    b>Clostridium perfringens epsilon toxin (ETX) rapidly kills MDCK II cells at 37°C, but not 4°C...
  84. Keyburn A, Portela R, Sproat K, Ford M, Bannam T, Yan X, et al. Vaccination with recombinant NetB toxin partially protects broiler chickens from necrotic enteritis. Vet Res. 2013;44:54 pubmed publisher
    NetB toxin from Clostridium perfringens is a major virulence factor in necrotic enteritis in poultry. In this study the efficacy of NetB as a vaccine antigen to protect chickens from necrotic enteritis was examined...
  85. Saleh N, Fathalla S, Nabil R, Mosaad A. Clinicopathological and immunological studies on toxoids vaccine as a successful alternative in controlling clostridial infection in broilers. Anaerobe. 2011;17:426-30 pubmed publisher
    The present study was conducted to evaluate the efficacy and safety of three vaccination regimes of Clostridium perfringens (C. perfringens) type A, C and combined A&C toxoids based on their clinical signs and immunological effects...
  86. Kaneko I, Miyamoto K, Mimura K, Yumine N, Utsunomiya H, Akimoto S, et al. Detection of enterotoxigenic Clostridium perfringens in meat samples by using molecular methods. Appl Environ Microbiol. 2011;77:7526-32 pubmed publisher
    ..Isolates carrying the Clostridium perfringens enterotoxin gene (cpe) on the chromosome or a plasmid rank among the most important food-borne pathogens...
  87. Jang S, Lillehoj H, Lee S, Lee K, Lillehoj E, Hong Y, et al. Vaccination with Clostridium perfringens recombinant proteins in combination with Montanide™ ISA 71 VG adjuvant increases protection against experimental necrotic enteritis in commercial broiler chickens. Vaccine. 2012;30:5401-6 pubmed publisher
    This study was performed to compare four Clostridium perfringens recombinant proteins as vaccine candidates using the Montanide™ ISA 71 VG adjuvant in an experimental model of necrotic enteritis...
  88. Rumah K, Linden J, Fischetti V, Vartanian T. Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease. PLoS ONE. 2013;8:e76359 pubmed publisher
    We have isolated Clostridium perfringens type B, an epsilon toxin-secreting bacillus, from a young woman at clinical presentation of Multiple Sclerosis (MS) with actively enhancing lesions on brain MRI...
  89. Paredes Sabja D, Sarker M. Interactions between Clostridium perfringens spores and Raw 264.7 macrophages. Anaerobe. 2012;18:148-56 pubmed publisher
    b>Clostridium perfringens is the causative agent of a variety of histotoxic infections in humans and animals. Studies on the early events of C...