prevotella intermedia

Summary

Summary: A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium is a common commensal in the gingival crevice and is often isolated from cases of gingivitis and other purulent lesions related to the mouth.

Top Publications

  1. Levesque C, Lamothe J, Frenette M. Coaggregation of Streptococcus salivarius with periodontopathogens: evidence for involvement of fimbriae in the interaction with Prevotella intermedia. Oral Microbiol Immunol. 2003;18:333-7 pubmed
    ..salivarius coaggregated with Fusobacterium nucleatum, Porphyromonas gingivalis, and Prevotella intermedia. However, only fimbriated S. salivarius cells were able to coaggregate with P...
  2. Okamoto M, Leung K, Ansai T, Sugimoto A, Maeda N. Inhibitory effects of green tea catechins on protein tyrosine phosphatase in Prevotella intermedia. Oral Microbiol Immunol. 2003;18:192-5 pubmed
    Members of the Prevotella intermedia group possess protein tyrosine phosphatase (PTPase). The purpose of this study was to investigate the effects of catechin derivatives from Japanese green tea on the activity of PTPase in P...
  3. Kim S, Ha M, Choi E, Choi J, Choi I. Prevotella intermedia lipopolysaccharide stimulates release of nitric oxide by inducing expression of inducible nitric oxide synthase. J Periodontal Res. 2004;39:424-31 pubmed
    The purpose of this study was to examine the effects of lipopolysaccharide from Prevotella intermedia, a major cause of inflammatory periodontal disease, on the production of nitric oxide (NO) and expression of inducible nitric oxide ..
  4. Gmür R, Thurnheer T. Direct quantitative differentiation between Prevotella intermedia and Prevotella nigrescens in clinical specimens. Microbiology. 2002;148:1379-87 pubmed
    ..a quantitative fluorescent in situ hybridization (FISH) assay for the differential identification of Prevotella intermedia and Prevotella nigrescens in clinical samples, and compares its performance with less discriminatory ..
  5. Mallorquí Fernández N, Manandhar S, Mallorquí Fernández G, Uson I, Wawrzonek K, Kantyka T, et al. A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A. J Biol Chem. 2008;283:2871-82 pubmed
    b>Prevotella intermedia is a major periodontopathogen contributing to human gingivitis and periodontitis. Such pathogens release proteases as virulence factors that cause deterrence of host defenses and tissue destruction...
  6. Wakabayashi H, Yamauchi K, Kobayashi T, Yaeshima T, Iwatsuki K, Yoshie H. Inhibitory effects of lactoferrin on growth and biofilm formation of Porphyromonas gingivalis and Prevotella intermedia. Antimicrob Agents Chemother. 2009;53:3308-16 pubmed publisher
    ..agents on the growth and biofilm formation of two periodontopathic bacteria, Porphyromonas gingivalis and Prevotella intermedia, which reside as biofilms in the subgingival plaque. The planktonic growth of P. gingivalis and P...
  7. Byrne D, Potempa J, Olczak T, Smalley J. Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermedia. Mol Oral Microbiol. 2013;28:219-29 pubmed publisher
    ..growth factor and a virulence regulator of the periodontal pathogens Porphyromonas gingivalis and Prevotella intermedia, which acquire it through the proteolytic degradation of haemoglobin and other haem-carrying plasma ..
  8. Yanagisawa M, Kuriyama T, Williams D, Nakagawa K, Karasawa T. Proteinase activity of prevotella species associated with oral purulent infection. Curr Microbiol. 2006;52:375-8 pubmed
    b>Prevotella intermedia and Prevotella nigrescens are often regarded as principal causes of acute dentoalveolar infection; however, other species within the genus are also known to be associated with such infection...
  9. Guan S, Nagata H, Shizukuishi S, Wu J. Degradation of human hemoglobin by Prevotella intermedia. Anaerobe. 2006;12:279-82 pubmed
    In this study, the ability of Prevotella intermedia, an obligate anaerobic rod, to degrade human hemoglobin was determined by SDS-PAGE and the degradation was quantified by scanning densitometry...

More Information

Publications69

  1. Yano T, Fukamachi H, Yamamoto M, Igarashi T. Characterization of L-cysteine desulfhydrase from Prevotella intermedia. Oral Microbiol Immunol. 2009;24:485-92 pubmed publisher
    ..To clarify the production mechanism of hydrogen sulfide in Prevotella intermedia, we found an L-cysteine desulfhydrase gene (lcs) homologue on the genome database of P...
  2. Ulrich M, Beer I, Braitmaier P, Dierkes M, Kummer F, Krismer B, et al. Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis. Thorax. 2010;65:978-84 pubmed publisher
    ..Whether obligate anaerobes contribute to the pathophysiology of CF lung disease is unknown...
  3. Suzuki N, Fukamachi H, Arimoto T, Yamamoto M, Igarashi T. Contribution of hly homologs to the hemolytic activity of Prevotella intermedia. Anaerobe. 2012;18:350-6 pubmed publisher
    b>Prevotella intermedia is a periodontal pathogen that requires iron for its growth...
  4. Yamanaka T, Furukawa T, Matsumoto Mashimo C, Yamane K, Sugimori C, Nambu T, et al. Gene expression profile and pathogenicity of biofilm-forming Prevotella intermedia strain 17. BMC Microbiol. 2009;9:11 pubmed publisher
    b>Prevotella intermedia (P. intermedia), a gram-negative, black-pigmented anaerobic rod, has been implicated in the development of chronic oral infection. P...
  5. Masakiyo Y, Yoshida A, Shintani Y, Takahashi Y, Ansai T, Takehara T. The identification of genes specific to Prevotella intermedia and Prevotella nigrescens using genomic subtractive hybridization. Anaerobe. 2010;16:265-9 pubmed publisher
    b>Prevotella intermedia and Prevotella nigrescens, which are often isolated from periodontal sites, were once considered two different genotypes of P. intermedia. Although the genomic sequence of P...
  6. Iyer D, Anaya Bergman C, Jones K, Yanamandra S, Sengupta D, Miyazaki H, et al. AdpC is a Prevotella intermedia 17 leucine-rich repeat internalin-like protein. Infect Immun. 2010;78:2385-96 pubmed publisher
    The oral bacterium Prevotella intermedia attaches to and invades gingival epithelial cells, fibroblasts, and endothelial cells...
  7. Takahashi N, Sato T. Dipeptide utilization by the periodontal pathogens Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens and Fusobacterium nucleatum. Oral Microbiol Immunol. 2002;17:50-4 pubmed
    Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens and Fusobacterium nucleatum, which can frequently be isolated from periodontal pockets, preferentially utilize proteins and peptides as growth substrates...
  8. Eick S, Pfister W. Comparison of microbial cultivation and a commercial PCR based method for detection of periodontopathogenic species in subgingival plaque samples. J Clin Periodontol. 2002;29:638-44 pubmed
    ..The purpose of this study was to validate the commercially available micro-Dent(R) test which employs probes for A. actinomycetemcomitans, P. gingivalis, P. intermedia, B. forsythus and T. denticola...
  9. Pelt P, Zimmermann B, Ulbrich N, Bernimoulin J. Effects of lipopolysaccharide extracted from Prevotella intermedia on bone formation and on the release of osteolytic mediators by fetal mouse osteoblasts in vitro. Arch Oral Biol. 2002;47:859-66 pubmed
    b>Prevotella intermedia, a Gram-negative obligate anaerobic black-pigmented oral bacterium, belongs to a small group of microorganisms that is closely associated with the initiation of periodontal diseases...
  10. Hashimoto M, Asai Y, Tamai R, Jinno T, Umatani K, Ogawa T. Chemical structure and immunobiological activity of lipid A from Prevotella intermedia ATCC 25611 lipopolysaccharide. FEBS Lett. 2003;543:98-102 pubmed
    The novel chemical structure and immunobiological activities of Prevotella intermedia ATCC 25611 lipid A were investigated. A lipopolysaccharide (LPS) preparation of P...
  11. Derdilopoulou F, Nonhoff J, Neumann K, Kielbassa A. Microbiological findings after periodontal therapy using curettes, Er:YAG laser, sonic, and ultrasonic scalers. J Clin Periodontol. 2007;34:588-98 pubmed
    ..To evaluate and compare the microbiological effects of hand instruments, Er:YAG-laser, sonic, and ultrasonic scalers in patients with chronic periodontitis. Patient perception of each treatment was documented...
  12. Alves A, Napimoga M, Klein M, Hofling J, Goncalves R. Increase in probing depth is correlated with a higher number of Prevotella intermedia genotypes. J Periodontol. 2006;77:61-6 pubmed
    The aims of this study were to determine the genotypic diversity of Prevotella intermedia in subgingival plaque samples by using two techniques, arbitrarily primed polymerase chain reaction (AP-PCR) and heteroduplex analysis, and to ..
  13. Yamanaka T, Yamane K, Furukawa T, Matsumoto Mashimo C, Sugimori C, Nambu T, et al. Comparison of the virulence of exopolysaccharide-producing Prevotella intermedia to exopolysaccharide non-producing periodontopathic organisms. BMC Infect Dis. 2011;11:228 pubmed publisher
    ..Evidence in the literature suggests that exopolysaccharides (EPS) produced by bacterial cells are essential for the expression of virulence in these organisms. Secreted EPSs form the framework in which microbial biofilms are built...
  14. Testa M, Ruiz de Valladares R, Benito de Cardenas I. Antagonistic interactions among Fusobacterium nucleatum and Prevotella intermedia with oral lactobacilli. Res Microbiol. 2003;154:669-75 pubmed
    ..The aim of this work was to evaluate possible antagonistic interactions among Fusobacterium nucleatum and Prevotella intermedia, isolated from periodontal pockets, and Lactobacillus casei, L. salivarius, L. rhamnosus and L...
  15. Shibata Y, Miwa Y, Hirai K, Fujimura S. Purification and partial characterization of a dipeptidyl peptidase from Prevotella intermedia. Oral Microbiol Immunol. 2003;18:196-8 pubmed
    A peptidase hydrolyzed X-Pro-p-nitroanilide was purified from the cell extract of Prevotella intermedia ATCC 25611 by ion-exchange chromatography and hydrophobic interaction chromatography...
  16. Choi E, Jin J, Lee J, Choi J, Choi I, Kim S. Melatonin inhibits Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-?B and STAT1 activity. J Pineal Res. 2011;50:197-206 pubmed publisher
    ..production of inflammatory mediators by murine macrophages stimulated with lipopolysaccharide (LPS) from Prevotella intermedia, a major cause of inflammatory reactions in the periodontium, and sought to determine the underlying ..
  17. Maeda H, Fujimoto C, Haruki Y, Maeda T, Kokeguchi S, Petelin M, et al. Quantitative real-time PCR using TaqMan and SYBR Green for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, tetQ gene and total bacteria. FEMS Immunol Med Microbiol. 2003;39:81-6 pubmed
    ..Primers and probes were designed for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia and total bacteria based on the nucleotide sequences of the respective 16S ribosomal RNA genes...
  18. Gomes B, Jacinto R, Pinheiro E, Sousa E, Zaia A, Ferraz C, et al. Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia and Prevotella nigrescens in endodontic lesions detected by culture and by PCR. Oral Microbiol Immunol. 2005;20:211-5 pubmed
    ..the presence of four black-pigmented bacteria, Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia and Prevotella nigrescens, in endodontic infections by culture and polymerase chain reaction (PCR) ..
  19. Guan S, He J, Zhang M, Shu L. Prevotella intermedia stimulates tissue-type plasminogen activator and plasminogen activator inhibitor-2 expression via multiple signaling pathways in human periodontal ligament cells. FEMS Immunol Med Microbiol. 2011;62:91-100 pubmed publisher
    b>Prevotella intermedia is an important periodontal pathogen that induces various inflammatory and immune responses. In this study, we investigated the effects of P...
  20. Guan S, Zhang M, He J, Wu J. Mitogen-activated protein kinases and phosphatidylinositol 3-kinase are involved in Prevotella intermedia-induced proinflammatory cytokines expression in human periodontal ligament cells. Biochem Biophys Res Commun. 2009;386:471-6 pubmed publisher
    ..In this study, we examined whether Prevotella intermedia induces proinflammatory cytokines expression in human periodontal ligament cells (hPDLs)...
  21. Tanaka S, Yoshida M, Murakami Y, Ogiwara T, Shoji M, Kobayashi S, et al. The relationship of Prevotella intermedia, Prevotella nigrescens and Prevotella melaninogenica in the supragingival plaque of children, caries and oral malodor. J Clin Pediatr Dent. 2008;32:195-200 pubmed
    ..P. intermedia, P. nigrescens, P. melaninogenica) in the supragingival plaques of 3 to 16-year-old children with different oral health conditions and oral malodor...
  22. Kim S, Choi E, Kim E, Shin S, Lee J, Choi J, et al. Prevotella intermedia lipopolysaccharide stimulates release of tumor necrosis factor-alpha through mitogen-activated protein kinase signaling pathways in monocyte-derived macrophages. FEMS Immunol Med Microbiol. 2007;51:407-13 pubmed
    The purpose of this study was to investigate the effects of lipopolysaccharide from Prevotella intermedia, a major cause of inflammatory periodontal disease, on the production of tumor necrosis factor (TNF)-alpha and the expression of ..
  23. Deschner J, Singhal A, Long P, Liu C, Piesco N, Agarwal S. Cleavage of CD14 and LBP by a protease from Prevotella intermedia. Arch Microbiol. 2003;179:430-6 pubmed
    ..In this study, it was determined that proteases from a periodontal pathogen, Prevotella intermedia, cleave CD14 and LBP, and thereby modulate the virulence of LPS...
  24. Guan S, Fu S, He J, Zhang M. Prevotella intermedia induces prostaglandin E2 via multiple signaling pathways. J Dent Res. 2011;90:121-7 pubmed publisher
    ..e., EP1-EP4). In this study, the authors examined whether Prevotella intermedia regulates PGE(2) production and EP expression in human periodontal ligament fibroblasts (hPDLs); they also ..
  25. Ford P, Gemmell E, Chan A, Carter C, Walker P, Bird P, et al. Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study. Oral Microbiol Immunol. 2006;21:206-11 pubmed
  26. Leung K, Lewis A, Concannon S, Yoshimoto H, Fukushima H. Prevotella intermedia native plasmid can be mobilized by an Escherichia coli conjugal IncP plasmid. Plasmid. 2002;48:64-72 pubmed
    We have determined the nucleotide sequence of a small Prevotella intermedia cryptic plasmid, pYHBi1, which consisted of sequences that were highly homologous to the amino acid sequence of the replication and mobilization proteins found ..
  27. Guan S, Nagata H, Maeda K, Kuboniwa M, Minamino N, Shizukuishi S. Purification and characterization of a hemoglobin-binding outer membrane protein of Prevotella intermedia. FEMS Microbiol Lett. 2004;235:333-9 pubmed
    An outer membrane hemoglobin-binding protein of Prevotella intermedia was identified and purified in the present study. Hemoglobin-binding protein was purified via a series of column chromatographic methods...
  28. Brook I, Frazier E. Immune response to Fusobacterium nucleatum and Prevotella intermedia in the sputum of patients with acute exacerbation of chronic bronchitis. Chest. 2003;124:832-3 pubmed
    ..To assess the role of anaerobic bacteria in acute exacerbation of chronic bronchitis (AECB)...
  29. Takahashi N. Acid-neutralizing activity during amino acid fermentation by Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum. Oral Microbiol Immunol. 2003;18:109-13 pubmed
    Acid-neutralizing activity during amino acid fermentation by washed cells of Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum was studied...
  30. Byrne D, Wawrzonek K, Jaworska A, Birss A, Potempa J, Smalley J. Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin. Biochem J. 2009;425:257-64 pubmed publisher
    The gram-negative oral anaerobe Prevotella intermedia forms an iron(III) protoporphyrin IX pigment from haemoglobin...
  31. Potempa M, Potempa J, Kantyka T, Nguyen K, Wawrzonek K, Manandhar S, et al. Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. PLoS Pathog. 2009;5:e1000316 pubmed publisher
    ..is an inflammatory disease of the supporting structures of the teeth caused by, among other pathogens, Prevotella intermedia. Many strains of P...
  32. Yu F, Iyer D, Anaya C, Lewis J. Identification and characterization of a cell surface protein of Prevotella intermedia 17 with broad-spectrum binding activity for extracellular matrix proteins. Proteomics. 2006;6:6023-32 pubmed
    b>Prevotella intermedia binds and invades a variety of host cells. This binding is most probably mediated through cell surface proteins termed adhesins...
  33. Smalley J, Silver J, Birss A, Withnall R, Titler P. The haem pigment of the oral anaerobes Prevotella nigrescens and Prevotella intermedia is composed of iron(III) protoporphyrin IX in the monomeric form. Microbiology. 2003;149:1711-8 pubmed
    ..Mössbauer, Raman and UV-visible spectrophotometry were used to characterize the haem pigment of Prevotella intermedia and Prevotella nigrescens...
  34. Tomazinho L, Avila Campos M. Detection of Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia, and Prevotella nigrescens in chronic endodontic infection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:285-8 pubmed
    ..PCR is a very sensitive technique for detecting DNA from bacterial cells. Culturing is only able to reveal living bacteria and is less sensitive for the identification of low numbers of bacterial cells...
  35. Cullinan M, Hamlet S, Westerman B, Palmer J, Faddy M, Seymour G. Acquisition and loss of Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia over a 5-year period: effect of a triclosan/copolymer dentifrice. J Clin Periodontol. 2003;30:532-41 pubmed
    ..study describes the natural history of Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia over a 5-year period and the effect of a triclosan/copolymer dentifrice on these organisms in a normal ..
  36. Puklo M, Guentsch A, Hiemstra P, Eick S, Potempa J. Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria. Oral Microbiol Immunol. 2008;23:328-35 pubmed publisher
    ..We compared neutrophilic content and the level of neutrophil-derived antimicrobial peptides in gingival crevicular fluid (GCF) in two clinical forms of severe periodontitis...
  37. Robert A, Rass M, Al Zoman K, Al Sohail A, Alsuwyed A, Ciancio S, et al. Determinants of periodontopathogens in microbiological monitoring of diabetic patients with periodontitis. Saudi Med J. 2010;31:1044-8 pubmed
    ..To determine and analyze the frequency of periodontopathogens in microbiological monitoring of diabetic patients with periodontitis...
  38. Kamaguchi A, Ohyama T, Sakai E, Nakamura R, Watanabe T, Baba H, et al. Adhesins encoded by the gingipain genes of Porphyromonas gingivalis are responsible for co-aggregation with Prevotella intermedia. Microbiology. 2003;149:1257-64 pubmed
    ..intermedia cells could adhere to GST-HGP17-conjugated Sepharose 4B beads, indicating that the HGP17 domain protein is responsible for Por. gingivalis vesicle-mediated aggregation of Pre. intermedia...
  39. Martinez Martinez R, Abud Mendoza C, Patiño Marín N, Rizo Rodríguez J, Little J, Loyola Rodriguez J. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol. 2009;36:1004-10 pubmed publisher
  40. Bornstein M, Hakimi B, Persson G. Microbiological findings in subjects with asymptomatic oral lichen planus: a cross-sectional comparative study. J Periodontol. 2008;79:2347-55 pubmed
    ..The bacterial colonization of the oral mucosa was evaluated in patients with asymptomatic oral lichen planus (OLP) and compared to the microbiologic status in mucosally healthy subjects...
  41. Takahashi K, Nishimura F, Kurihara M, Iwamoto Y, Takashiba S, Miyata T, et al. Subgingival microflora and antibody responses against periodontal bacteria of young Japanese patients with type 1 diabetes mellitus. J Int Acad Periodontol. 2001;3:104-11 pubmed
    ..tests for four periodontal pathogens, Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia and Capnocytophaga ochracea were performed using 16S ribosomal RNA-based polymerase chain reaction methods...
  42. Mombelli A, Casagni F, Madianos P. Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review. J Clin Periodontol. 2002;29 Suppl 3:10-21; discussion 37-8 pubmed
    ..The purpose of this study was to determine to what extent the presence or absence of periodontal pathogens can distinguish between subjects with chronic and aggressive periodontitis...
  43. Yu F, Anaya C, Lewis J. Outer membrane proteome of Prevotella intermedia 17: identification of thioredoxin and iron-repressible hemin uptake loci. Proteomics. 2007;7:403-12 pubmed
    Although hemin is an indispensable nutrient for the oral pathogen Prevotella intermedia, not much is known regarding the molecular mechanisms of hemin acquisition...
  44. Moen K, Brun J, Madland T, Tynning T, Jonsson R. Immunoglobulin G and A antibody responses to Bacteroides forsythus and Prevotella intermedia in sera and synovial fluids of arthritis patients. Clin Diagn Lab Immunol. 2003;10:1043-50 pubmed
    ..was to investigate immunoglobulin G (IgG) and IgA antibody immune responses to Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, and Candida albicans in the sera of patients with rheumatoid arthritis (RA), the ..
  45. Takanashi K, Kishi M, Okuda K, Ishihara K. Colonization by Porphyromonas gingivalis and Prevotella intermedia from teeth to osseointegrated implant regions. Bull Tokyo Dent Coll. 2004;45:77-85 pubmed
    ..teeth and implants in 12 patients in whom a dental implant was indicated, and Porphyromonas gingivalis and Prevotella intermedia were detected using polymerase chain reaction (PCR)...
  46. Sugawara S, Yang S, Iki K, Hatakeyama J, Tamai R, Takeuchi O, et al. Monocytic cell activation by Nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2. Infect Immun. 2001;69:4951-7 pubmed
    ..LPS) preparations from gram-negative black-pigmented bacteria such as Porphyromonas gingivalis and Prevotella intermedia activate cells from non-LPS-responsive C3H/HeJ mice, but it is still unclear whether this activity is due ..
  47. Baumgartner J, Watkins B, Bae K, Xia T. Association of black-pigmented bacteria with endodontic infections. J Endod. 1999;25:413-5 pubmed
    ..reaction and specific primers for 16S r-RNA genes were used to differentiate Prevotella nigrescens from Prevotella intermedia. Twenty-two (55%) samples were positive for the growth of BPB...
  48. Tompkins G, Wood D, Birchmeier K. Detection and comparison of specific hemin binding by Porphyromonas gingivalis and Prevotella intermedia. J Bacteriol. 1997;179:620-6 pubmed
    ..hemin binding by the periodontal anaerobic black-pigmenting bacteria (BPB) Porphyromonas gingivalis and Prevotella intermedia. The assay included physiological concentrations of the hemin-binding protein rabbit serum albumin (RSA) ..
  49. Doungudomdacha S, Rawlinson A, Walsh T, Douglas C. Effect of non-surgical periodontal treatment on clinical parameters and the numbers of Porphyromonas gingivalis, Prevotella intermedia and Actinobacillus actinomycetemcomitans at adult periodontitis sites. J Clin Periodontol. 2001;28:437-45 pubmed
    The purpose of this study was to relate the numbers of Porphyromonas gingivalis, Prevotella intermedia and Actinobacillus actinomycetemcomitans cells to clinical parameters at diseased and healthy periodontal sites before and after non-..
  50. Kamaguch A, Nakayama K, Ohyama T, Watanabe T, Okamoto M, Baba H. Coaggregation of Porphyromonas gingivalis and Prevotella intermedia. Microbiol Immunol. 2001;45:649-56 pubmed
    Porphyromonas gingivalis cells coaggregated with Prevotella intermedia cells. The coaggregation was inhibited with L-arginine, L-lysine, Nalpha-p-tosyl-L-lysine chloromethyl ketone, trypsin inhibitor, and leupeptin...
  51. Haffajee A, Socransky S. Relationship of cigarette smoking to the subgingival microbiota. J Clin Periodontol. 2001;28:377-88 pubmed
    ..Thus, the purpose of the present investigation was to examine the prevalence, proportions and levels of the subgingival species in adult subjects who were current, past or never smokers...
  52. Miyasaki K, Iofel R, Oren A, Huynh T, Lehrer R. Killing of Fusobacterium nucleatum, Porphyromonas gingivalis and Prevotella intermedia by protegrins. J Periodontal Res. 1998;33:91-8 pubmed
    ..against Fusobacterium nucleatum, and black-pigmented organisms including Porphyromonas gingivalis and Prevotella intermedia. Strains of both F...
  53. Tokuda M, Sakuta T, Fushuku A, Torii M, Nagaoka S. Regulation of interleukin-6 expression in human dental pulp cell cultures stimulated with Prevotella intermedia lipopolysaccharide. J Endod. 2001;27:273-7 pubmed
    Interleukin (IL)-6 expression in human dental pulp cell cultures after stimulation with Prevotella intermedia lipopolysaccharide (LPS) was investigated by Northern blot analysis, enzyme immunoassay, and bioassay...
  54. Wassenaar A, Reinhardus C, Abraham Inpijn L, Snijders A, Kievits F. Characteristics of Prevotella intermedia-specific CD4+ T cell clones from peripheral blood of a chronic adult periodontitis patient. Clin Exp Immunol. 1998;113:105-10 pubmed
    ..CD4+ T cells specific for Prevotella intermedia can be isolated from lesional gingiva, suggesting an active role for CD4+ T cells in the response to this ..
  55. Bostrom L, Bergstrom J, Dahlen G, Linder L. Smoking and subgingival microflora in periodontal disease. J Clin Periodontol. 2001;28:212-9 pubmed
    ..The present investigation was undertaken to analyze the influence of smoking on the periodontal disease associated subgingival microflora. The population included 33 smokers and 31 non-smokers in the age range 36-86 years...
  56. Lie M, van der Weijden G, Timmerman M, Loos B, van Steenbergen T, Van der Velden U. Occurrence of Prevotella intermedia and Prevotella nigrescens in relation to gingivitis and gingival health. J Clin Periodontol. 2001;28:189-93 pubmed
    The occurrence of Prevotella intermedia (Pi) and Prevotella nigrescens (Pn) in relation to natural gingivitis, gingival health and 14-day experimental gingivitis was investigated in 25 non-dental students.
  57. Kononen E, Wolf J, Mättö J, Frandsen E, Poulsen K, Jousimies Somer H, et al. The Prevotella intermedia group organisms in young children and their mothers as related to maternal periodontal status. J Periodontal Res. 2000;35:329-34 pubmed
    Currently, the Prevotella intermedia group includes three biochemically and phylogenetically related species: Prevotella intermedia, Prevotella nigrescens, and the newly described Prevotella pallens...
  58. Leung K, Torres B. Prevotella intermedia stimulates expansion of Vbeta-specific CD4(+) T cells. Infect Immun. 2000;68:5420-4 pubmed
    ..The purpose of this study was to determine whether Prevotella intermedia, a putative periodontal pathogen, activates populations of specific Vbeta on CD4(+) T cells...
  59. Lopez N. Occurrence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia in progressive adult periodontitis. J Periodontol. 2000;71:948-54 pubmed
    Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia are the major periodontal bacteria species in most forms of progressive periodontitis in Scandinavia and the United States...
  60. Hamlet S, Cullinan M, Westerman B, Lindeman M, Bird P, Palmer J, et al. Distribution of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia in an Australian population. J Clin Periodontol. 2001;28:1163-71 pubmed
    ..describes (i) the natural distribution of the three putative periodontopathogens Porphyromonas gingivalis, Prevotella intermedia and Actinobacillus actinomycetemcomitans in an Australian population and (ii) the relationship between ..