porphyromonas gingivalis

Summary

Summary: A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.

Top Publications

  1. Priyadarshini R, Cugini C, Arndt A, Chen T, Tjokro N, Goodman S, et al. The nucleoid-associated protein HU? affects global gene expression in Porphyromonas gingivalis. Microbiology. 2013;159:219-29 pubmed publisher
    ..Like Escherichia coli, the genome of Porphyromonas gingivalis is predicted to encode both the HU? (PG1258) and the HU? (PG0121) subunit...
  2. Mkonyi L, Bletsa A, Bolstad A, Bakken V, Wiig H, Berggreen E. Gingival lymphatic drainage protects against Porphyromonas gingivalis-induced bone loss in mice. Am J Pathol. 2012;181:907-16 pubmed publisher
    ..Mice were orally infected with human Porphyromonas gingivalis and observed for 42 days...
  3. Quirke A, Lugli E, Wegner N, Hamilton B, Charles P, Chowdhury M, et al. Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis. Ann Rheum Dis. 2014;73:263-9 pubmed publisher
    ..by autoimmunity to citrullinated proteins, and there is increasing epidemiologic evidence linking Porphyromonas gingivalis to RA...
  4. Murakami Y, Kawata A, Seki Y, Koh T, Yuhara K, Maruyama T, et al. Comparative inhibitory effects of magnolol, honokiol, eugenol and bis-eugenol on cyclooxygenase-2 expression and nuclear factor-kappa B activation in RAW264.7 macrophage-like cells stimulated with fimbriae of Porphyromonas gingivalis. In Vivo. 2012;26:941-50 pubmed
    ..7 macrophage-like cells stimulated with the fimbriae of Porphyromonas gingivalis, an oral anaerobe. The cytotoxicity of magnolol, honokiol, eugenol and bis-eugenol against RAW264...
  5. Yanamandra S, Sarrafee S, Anaya Bergman C, Jones K, Lewis J. Role of the Porphyromonas gingivalis extracytoplasmic function sigma factor, SigH. Mol Oral Microbiol. 2012;27:202-19 pubmed publisher
    Little is known about the regulatory mechanisms that allow Porphyromonas gingivalis to survive in the oral cavity. Here we characterize the sigma (?) factor SigH, one of six extracytoplasmic function (ECF) ? factors encoded in the P...
  6. Irshad M, van der Reijden W, Crielaard W, Laine M. In vitro invasion and survival of Porphyromonas gingivalis in gingival fibroblasts; role of the capsule. Arch Immunol Ther Exp (Warsz). 2012;60:469-76 pubmed publisher
    b>Porphyromonas gingivalis is a Gram-negative, anaerobic bacterium involved in periodontitis and peri-implantitis that can invade and survive inside host cells in vitro. P...
  7. Kishi M, Hasegawa Y, Nagano K, Nakamura H, Murakami Y, Yoshimura F. Identification and characterization of novel glycoproteins involved in growth and biofilm formation by Porphyromonas gingivalis. Mol Oral Microbiol. 2012;27:458-70 pubmed publisher
    b>Porphyromonas gingivalis has been implicated as a major pathogen associated with chronic periodontitis. To extend our knowledge of post-translational protein glycosylation in P...
  8. Ohara Nemoto Y, Rouf S, Naito M, Yanase A, Tetsuo F, Ono T, et al. Identification and characterization of prokaryotic dipeptidyl-peptidase 5 from Porphyromonas gingivalis. J Biol Chem. 2014;289:5436-48 pubmed publisher
    b>Porphyromonas gingivalis, a Gram-negative asaccharolytic anaerobe, is a major causative organism of chronic periodontitis...
  9. Taxman D, Swanson K, Broglie P, Wen H, Holley Guthrie E, Huang M, et al. Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis. J Biol Chem. 2012;287:32791-9 pubmed
    ..We postulated that the periodontal pathogen, Porphyromonas gingivalis may suppress the inflammasome as a mechanism for its low immunogenicity and pathogenic synergy with other,..
  10. Bondy Carey J, Galicia J, Bagaitkar J, Potempa J, Potempa B, Kinane D, et al. Neutrophils alter epithelial response to Porphyromonas gingivalis in a gingival crevice model. Mol Oral Microbiol. 2013;28:102-13 pubmed publisher
    A gingival crevice model (epithelial cell-Porphyromonas gingivalis-neutrophil) was established and used to profile gingipain, matrix metalloproteinase (MMP), MMP mediators [neutrophil gelatinase-associated lipocalin (NGAL) and tissue ..

Detail Information

Publications94

  1. Priyadarshini R, Cugini C, Arndt A, Chen T, Tjokro N, Goodman S, et al. The nucleoid-associated protein HU? affects global gene expression in Porphyromonas gingivalis. Microbiology. 2013;159:219-29 pubmed publisher
    ..Like Escherichia coli, the genome of Porphyromonas gingivalis is predicted to encode both the HU? (PG1258) and the HU? (PG0121) subunit...
  2. Mkonyi L, Bletsa A, Bolstad A, Bakken V, Wiig H, Berggreen E. Gingival lymphatic drainage protects against Porphyromonas gingivalis-induced bone loss in mice. Am J Pathol. 2012;181:907-16 pubmed publisher
    ..Mice were orally infected with human Porphyromonas gingivalis and observed for 42 days...
  3. Quirke A, Lugli E, Wegner N, Hamilton B, Charles P, Chowdhury M, et al. Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis. Ann Rheum Dis. 2014;73:263-9 pubmed publisher
    ..by autoimmunity to citrullinated proteins, and there is increasing epidemiologic evidence linking Porphyromonas gingivalis to RA...
  4. Murakami Y, Kawata A, Seki Y, Koh T, Yuhara K, Maruyama T, et al. Comparative inhibitory effects of magnolol, honokiol, eugenol and bis-eugenol on cyclooxygenase-2 expression and nuclear factor-kappa B activation in RAW264.7 macrophage-like cells stimulated with fimbriae of Porphyromonas gingivalis. In Vivo. 2012;26:941-50 pubmed
    ..7 macrophage-like cells stimulated with the fimbriae of Porphyromonas gingivalis, an oral anaerobe. The cytotoxicity of magnolol, honokiol, eugenol and bis-eugenol against RAW264...
  5. Yanamandra S, Sarrafee S, Anaya Bergman C, Jones K, Lewis J. Role of the Porphyromonas gingivalis extracytoplasmic function sigma factor, SigH. Mol Oral Microbiol. 2012;27:202-19 pubmed publisher
    Little is known about the regulatory mechanisms that allow Porphyromonas gingivalis to survive in the oral cavity. Here we characterize the sigma (?) factor SigH, one of six extracytoplasmic function (ECF) ? factors encoded in the P...
  6. Irshad M, van der Reijden W, Crielaard W, Laine M. In vitro invasion and survival of Porphyromonas gingivalis in gingival fibroblasts; role of the capsule. Arch Immunol Ther Exp (Warsz). 2012;60:469-76 pubmed publisher
    b>Porphyromonas gingivalis is a Gram-negative, anaerobic bacterium involved in periodontitis and peri-implantitis that can invade and survive inside host cells in vitro. P...
  7. Kishi M, Hasegawa Y, Nagano K, Nakamura H, Murakami Y, Yoshimura F. Identification and characterization of novel glycoproteins involved in growth and biofilm formation by Porphyromonas gingivalis. Mol Oral Microbiol. 2012;27:458-70 pubmed publisher
    b>Porphyromonas gingivalis has been implicated as a major pathogen associated with chronic periodontitis. To extend our knowledge of post-translational protein glycosylation in P...
  8. Ohara Nemoto Y, Rouf S, Naito M, Yanase A, Tetsuo F, Ono T, et al. Identification and characterization of prokaryotic dipeptidyl-peptidase 5 from Porphyromonas gingivalis. J Biol Chem. 2014;289:5436-48 pubmed publisher
    b>Porphyromonas gingivalis, a Gram-negative asaccharolytic anaerobe, is a major causative organism of chronic periodontitis...
  9. Taxman D, Swanson K, Broglie P, Wen H, Holley Guthrie E, Huang M, et al. Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis. J Biol Chem. 2012;287:32791-9 pubmed
    ..We postulated that the periodontal pathogen, Porphyromonas gingivalis may suppress the inflammasome as a mechanism for its low immunogenicity and pathogenic synergy with other,..
  10. Bondy Carey J, Galicia J, Bagaitkar J, Potempa J, Potempa B, Kinane D, et al. Neutrophils alter epithelial response to Porphyromonas gingivalis in a gingival crevice model. Mol Oral Microbiol. 2013;28:102-13 pubmed publisher
    A gingival crevice model (epithelial cell-Porphyromonas gingivalis-neutrophil) was established and used to profile gingipain, matrix metalloproteinase (MMP), MMP mediators [neutrophil gelatinase-associated lipocalin (NGAL) and tissue ..
  11. Carvalho Filho P, Trindade S, Olczak T, Sampaio G, Oliveira Neto M, Santos H, et al. Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells. BMC Microbiol. 2013;13:206 pubmed publisher
    ..investigate the expression of Fas and Bcl-2 proteins by CD3+ T cells in vitro under stimulation by total Porphyromonas gingivalis antigens and purified recombinant P. gingivalis HmuY protein...
  12. de Diego I, Veillard F, Guevara T, Potempa B, Sztukowska M, Potempa J, et al. Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases. J Biol Chem. 2013;288:14287-96 pubmed publisher
    ..peptidase gingipain B (RgpB), which is the major virulence factor secreted by the periodontopathogen Porphyromonas gingivalis that attacks host vasculature and defense proteins...
  13. Abe T, Hosur K, Hajishengallis E, Reis E, Ricklin D, Lambris J, et al. Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist. J Immunol. 2012;189:5442-8 pubmed publisher
    ..These findings not only reveal a crucial cooperation between C5aR and TLR2 in periodontal inflammation but also provide proof-of-concept for local targeting of C5aR as a powerful candidate for the treatment of human periodontitis. ..
  14. Berker E, Kantarci A, Hasturk H, Van Dyke T. Blocking proinflammatory cytokine release modulates peripheral blood mononuclear cell response to Porphyromonas gingivalis. J Periodontol. 2013;84:1337-45 pubmed publisher
    ..cytokine (IL-4 and IL-10) production from peripheral blood mononuclear cells (PBMCs) in response to Porphyromonas gingivalis. PBMCs were isolated from individuals diagnosed with CP or healthy individuals and cultured for 24 hours...
  15. Scher J, Ubeda C, Equinda M, Khanin R, Buischi Y, Viale A, et al. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum. 2012;64:3083-94 pubmed publisher
    ..Anti-Porphyromonas gingivalis antibody testing was performed to assess prior exposure to the bacterial pathogen P gingivalis...
  16. Trindade S, Olczak T, Gomes Filho I, de Moura Costa L, Vale V, Galdino Neto M, et al. Porphyromonas gingivalis HmuY-induced production of interleukin-6 and IL-6 polymorphism in chronic periodontitis. J Periodontol. 2013;84:650-5 pubmed publisher
    ..without periodontitis (NP) and to measure the production of IL-6 by whole blood cells stimulated with Porphyromonas gingivalis HmuY protein...
  17. Kunnen A, Dekker D, van Pampus M, Harmsen H, Aarnoudse J, Abbas F, et al. Cytokine production induced by non-encapsulated and encapsulated Porphyromonas gingivalis strains. Arch Oral Biol. 2012;57:1558-66 pubmed publisher
    Although the exact reason is not known, encapsulated gram-negative Porphyromonas gingivalis strains are more virulent than non-encapsulated strains...
  18. Ammann T, Bostanci N, Belibasakis G, Thurnheer T. Validation of a quantitative real-time PCR assay and comparison with fluorescence microscopy and selective agar plate counting for species-specific quantification of an in vitro subgingival biofilm model. J Periodontal Res. 2013;48:517-26 pubmed publisher
  19. Osbourne D, Aruni A, Dou Y, Perry C, Boskovic D, Roy F, et al. VimA-dependent modulation of the secretome in Porphyromonas gingivalis. Mol Oral Microbiol. 2012;27:420-35 pubmed publisher
    The VimA protein of Porphyromonas gingivalis is a multifunctional protein involved in cell surface biogenesis...
  20. Seo T, Cha S, Kim T, Lee J, Woo K. Porphyromonas gingivalis-derived lipopolysaccharide-mediated activation of MAPK signaling regulates inflammatory response and differentiation in human periodontal ligament fibroblasts. J Microbiol. 2012;50:311-9 pubmed publisher
    b>Porphyromonas gingivalis (P.g.), which is a potential pathogen for periodontal diseases, contains lipopolysaccharide (LPS), and this endotoxin stimulates a variety of cellular responses. At present, P.g...
  21. Ding P, Wang C, Darveau R, Jin L. Porphyromonas gingivalis LPS stimulates the expression of LPS-binding protein in human oral keratinocytes in vitro. Innate Immun. 2013;19:66-75 pubmed publisher
    ..b>Porphyromonas gingivalis is a key pathogen of periodontal disease. P...
  22. Polak D, Naddaf R, Shapira L, Weiss E, Houri Haddad Y. Protective potential of non-dialyzable material fraction of cranberry juice on the virulence of P. gingivalis and F. nucleatum mixed infection. J Periodontol. 2013;84:1019-25 pubmed publisher
    ..The aim of this study is to explore the effect of high molecular weight cranberry constituent (non-dialyzable material [NDM]) on the virulence of a mixed infection with Porphyromonas gingivalis and Fusobacterium nucleatum in mice.
  23. Darveau R, Hajishengallis G, Curtis M. Porphyromonas gingivalis as a potential community activist for disease. J Dent Res. 2012;91:816-20 pubmed publisher
    ..Consequently, these bacteria have been labeled 'periopathogens'. Studies with one of these bacteria, Porphyromonas gingivalis, have revealed that it contains several different mechanisms which either impede or modulate periodontal ..
  24. Chang P, Chien L, Chong L, Kuo Y, Hsiao J. Glycated matrix up-regulates inflammatory signaling similarly to Porphyromonas gingivalis lipopolysaccharide. J Periodontal Res. 2013;48:184-93 pubmed publisher
    ..PDLCs) and mesenchymal stem cells (MSCs) were cultured under simulated conditions of hyperglycemia, Porphyromonas gingivalis lipopolysaccharide (LPS) stimulation and matrix glycation...
  25. Zenobia C, Hasturk H, Nguyen D, Van Dyke T, Kantarci A, Darveau R. Porphyromonas gingivalis lipid A phosphatase activity is critical for colonization and increasing the commensal load in the rabbit ligature model. Infect Immun. 2014;82:650-9 pubmed publisher
    ..b>Porphyromonas gingivalis contains lipid A with structural heterogeneity that has been postulated to contribute to the initiation ..
  26. Liao J, Zhao L, Yoshioka M, Hinode D, Grenier D. Effects of Japanese traditional herbal medicines (Kampo) on growth and virulence properties of Porphyromonas gingivalis and viability of oral epithelial cells. Pharm Biol. 2013;51:1538-44 pubmed publisher
    ..We hypothesized that Kampos may have unidentified properties that may be beneficial in periodontitis, an inflammatory disease affecting the tooth-supporting tissues...
  27. Choi C, Spooner R, Deguzman J, Koutouzis T, Ojcius D, Yilmaz O. Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence. Cell Microbiol. 2013;15:961-76 pubmed publisher
    ..Furthermore, Porphyromonas gingivalis, an oral opportunistic pathogen, upregulated the antioxidant glutathione response, modulated eATP-induced ..
  28. Zhang W, Ju J, Rigney T, TRIBBLE G. Integrin ?5?1-fimbriae binding and actin rearrangement are essential for Porphyromonas gingivalis invasion of osteoblasts and subsequent activation of the JNK pathway. BMC Microbiol. 2013;13:5 pubmed publisher
    ..The Gram-negative oral anaerobe, Porphyromonas gingivalis, is strongly associated with periodontitis, and it has been shown previously that P...
  29. Palm E, Khalaf H, Bengtsson T. Porphyromonas gingivalis downregulates the immune response of fibroblasts. BMC Microbiol. 2013;13:155 pubmed publisher
    b>Porphyromonas gingivalis is a key pathogen in periodontitis, an inflammatory disease leading to destruction of bone and tooth-supporting tissue. P...
  30. Zhu Y, Dashper S, Chen Y, Crawford S, Slakeski N, Reynolds E. Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development. PLoS ONE. 2013;8:e71727 pubmed publisher
    ..b>Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia have all been implicated as playing roles in disease ..
  31. Hirano T, Beck D, Demuth D, Hackett M, Lamont R. Deep sequencing of Porphyromonas gingivalis and comparative transcriptome analysis of a LuxS mutant. Front Cell Infect Microbiol. 2012;2:79 pubmed publisher
    b>Porphyromonas gingivalis is a major etiological agent in chronic and aggressive forms of periodontal disease...
  32. Die L, Yan P, Jun Jiang Z, Min Hua T, Cai W, Xing L. Glycogen synthase kinase-3 beta inhibitor suppresses Porphyromonas gingivalis lipopolysaccharide-induced CD40 expression by inhibiting nuclear factor-kappa B activation in mouse osteoblasts. Mol Immunol. 2012;52:38-49 pubmed publisher
    ..expression of CD40, as well as production of pro-inflammatory cytokines IL-6, TNF-? and IL-1?, in the Porphyromonas gingivalis-lipopolysaccharide (LPS)-stimulated murine osteoblastic-like MC3T3-E1 cells...
  33. Jain S, Coats S, Chang A, Darveau R. A novel class of lipoprotein lipase-sensitive molecules mediates Toll-like receptor 2 activation by Porphyromonas gingivalis. Infect Immun. 2013;81:1277-86 pubmed publisher
    Infection by the chronic periodontitis-associated pathogen Porphyromonas gingivalis activates a Toll-like receptor 2 (TLR2) response that triggers inflammation in the host but also promotes bacterial persistence...
  34. Nebel D, Arvidsson J, Lillqvist J, Holm A, Nilsson B. Differential effects of LPS from Escherichia coli and Porphyromonas gingivalis on IL-6 production in human periodontal ligament cells. Acta Odontol Scand. 2013;71:892-8 pubmed publisher
    ..This study investigates underlying mechanisms behind regulation of PDL cell IL-6 production by E. coli and P. gingivalis LPS...
  35. Kobayashi N, Suzuki J, Ogawa M, Aoyama N, Hanatani T, Hirata Y, et al. Porphyromonas gingivalis accelerates neointimal formation after arterial injury. J Vasc Res. 2012;49:417-24 pubmed publisher
    ..However, the effects of a periodontal infection on vascular remodeling have not been examined. We assess the hypothesis that periodontal infection could promote neointimal formation after an arterial injury...
  36. Moutsopoulos N, Kling H, Angelov N, Jin W, Palmer R, Nares S, et al. Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis. J Autoimmun. 2012;39:294-303 pubmed publisher
    ..we studied involved tissues ex vivo and investigated host cell responses to the periodontal pathogen Porphyromonas gingivalis, in vitro...
  37. Lewis J, Yanamandra S, Anaya Bergman C. HcpR of Porphyromonas gingivalis is required for growth under nitrosative stress and survival within host cells. Infect Immun. 2012;80:3319-31 pubmed publisher
    Although the Gram-negative, anaerobic periodontopathogen Porphyromonas gingivalis must withstand nitrosative stress, which is particularly high in the oral cavity, the mechanisms allowing for protection against such stress are not known ..
  38. Cai Y, Kurita Ochiai T, Hashizume T, Yamamoto M. Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis. Pathog Dis. 2013;67:76-83 pubmed publisher
    The purpose of this study was to determine whether epigallocatechin-3-gallate (EGCG) ameliorates Porphyromonas gingivalis-induced atherosclerosis. EGCG is a polyphenol extract from green tea with health benefits and P...
  39. Krishnan K, Duncan M. Role of sodium in the RprY-dependent stress response in Porphyromonas gingivalis. PLoS ONE. 2013;8:e63180 pubmed publisher
    b>Porphyromonas gingivalis is a Gram-negative oral anaerobe which is strongly associated with periodontal disease. Environmental changes in the gingival sulcus trigger the growth of P...
  40. Park E, Na H, Song Y, Shin S, Kim Y, Chung J. Activation of NLRP3 and AIM2 inflammasomes by Porphyromonas gingivalis infection. Infect Immun. 2014;82:112-23 pubmed publisher
    b>Porphyromonas gingivalis, a major periodontopathogen, is involved in the pathogenesis of periodontitis...
  41. CARRION J, Scisci E, Miles B, Sabino G, Zeituni A, Gu Y, et al. Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential. J Immunol. 2012;189:3178-87 pubmed publisher
    ..Analysis of the blood mDC microbiome by 16S rDNA sequencing showed Porphyromonas gingivalis and other species, including (cultivable) Burkholderia cepacia. The mDC carriage rate with P...
  42. Rodrigues P, Reyes L, Chadda A, Bélanger M, Wallet S, Akin D, et al. Porphyromonas gingivalis strain specific interactions with human coronary artery endothelial cells: a comparative study. PLoS ONE. 2012;7:e52606 pubmed publisher
    Both epidemiologic and experimental findings suggest that infection with Porphyromonas gingivalis exacerbates progression of atherosclerosis. As P...
  43. Gaddis D, Maynard C, Weaver C, Michalek S, Katz J. Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-? T cell response to Porphyromonas gingivalis. J Leukoc Biol. 2013;93:21-31 pubmed publisher
    ..g. exposure and suggest multiple inhibitory mechanisms potentially used by P.g. to evade the host's immune response, thus allowing its persistence in the host...
  44. Klein B, Tenorio E, Lazinski D, Camilli A, Duncan M, Hu L. Identification of essential genes of the periodontal pathogen Porphyromonas gingivalis. BMC Genomics. 2012;13:578 pubmed publisher
    b>Porphyromonas gingivalis is a Gram-negative anaerobic bacterium associated with periodontal disease onset and progression...
  45. Luo W, Wang C, Jin L. Baicalin downregulates Porphyromonas gingivalis lipopolysaccharide-upregulated IL-6 and IL-8 expression in human oral keratinocytes by negative regulation of TLR signaling. PLoS ONE. 2012;7:e51008 pubmed publisher
    ..It also increases the risk of cardiovascular disease and diabetes mellitus. Porphyromonas gingivalis lipopolysaccharide (LPS) is a key virulent attribute that significantly contributes to periodontal ..
  46. Tang X, Pan Y, Zhao Y. Vitamin D inhibits the expression of interleukin-8 in human periodontal ligament cells stimulated with Porphyromonas gingivalis. Arch Oral Biol. 2013;58:397-407 pubmed publisher
    ..present study aimed to discover the effects of 1a,25-dihydroxyvitamin D3 (1,25D) on the expressions of interleukin (IL)-6 and IL-8 in human periodontal ligament cells (hPDLCs) stimulated with Porphyromonas gingivalis (P. gingivalis) W83.
  47. Sato K, Yukitake H, Narita Y, Shoji M, Naito M, Nakayama K. Identification of Porphyromonas gingivalis proteins secreted by the Por secretion system. FEMS Microbiol Lett. 2013;338:68-76 pubmed publisher
    The Gram-negative bacterium Porphyromonas gingivalis possesses a number of potential virulence factors for periodontopathogenicity...
  48. Zainal Abidin Z, Veith P, Dashper S, Zhu Y, Catmull D, Chen Y, et al. Differential proteomic analysis of a polymicrobial biofilm. J Proteome Res. 2012;11:4449-64 pubmed publisher
    b>Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia exist in a polymicrobial biofilm associated with chronic periodontitis...
  49. Hajishengallis G, Lambris J. Complement and dysbiosis in periodontal disease. Immunobiology. 2012;217:1111-6 pubmed publisher
    ..However, the periodontal bacterium Porphyromonas gingivalis expresses C5 convertase-like enzymatic activity and adeptly exploits complement-TLR crosstalk to subvert ..
  50. Padial Molina M, Volk S, Rodriguez J, Marchesan J, Galindo Moreno P, Rios H. Tumor necrosis factor-? and Porphyromonas gingivalis lipopolysaccharides decrease periostin in human periodontal ligament fibroblasts. J Periodontol. 2013;84:694-703 pubmed publisher
    ..The aim of this study is to evaluate whether periodontal disease-associated pathogen-related virulence factors (endotoxins/lipopolysaccharides [LPS]) and proinflammatory cytokines alter the expression of periostin in PDL cells...
  51. Mikuls T, Thiele G, Deane K, Payne J, O Dell J, Yu F, et al. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis Rheum. 2012;64:3522-30 pubmed publisher
    To examine the relationship of Porphyromonas gingivalis to the presence of autoantibodies in individuals at risk of rheumatoid arthritis (RA).
  52. Bielecki M, Wojtowicz H, Olczak T. Differential roles of tryptophan residues in conformational stability of Porphyromonas gingivalis HmuY hemophore. BMC Biochem. 2014;15:2 pubmed publisher
    ..The aim of this study was to characterize structural features of HmuY variants in the presence and absence of heme with respect to roles of tryptophan residues in conformational stability...
  53. Hirano T, Beck D, Wright C, Demuth D, Hackett M, Lamont R. Regulon controlled by the GppX hybrid two component system in Porphyromonas gingivalis. Mol Oral Microbiol. 2013;28:70-81 pubmed publisher
    The periodontal pathogen Porphyromonas gingivalis experiences a number of environmental conditions in the oral cavity, and must monitor and respond to a variety of environmental cues...
  54. van der Post S, Subramani D, Bäckström M, Johansson M, Vester Christensen M, Mandel U, et al. Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB). J Biol Chem. 2013;288:14636-46 pubmed publisher
    ..Culture supernatants of Porphyromonas gingivalis, a bacterium that secretes proteases responsible for periodontitis, cleaved the MUC2 C-terminal region, ..
  55. Bostanci N, Thurnheer T, Aduse Opoku J, Curtis M, Zinkernagel A, Belibasakis G. Porphyromonas gingivalis regulates TREM-1 in human polymorphonuclear neutrophils via its gingipains. PLoS ONE. 2013;8:e75784 pubmed publisher
    ..b>Porphyromonas gingivalis is a Gram-negative anaerobe highly implicated in the inflammatory processes governing periodontal disease,..
  56. Chui C, Hiratsuka K, Aoki A, Takeuchi Y, Abiko Y, Izumi Y. Blue LED inhibits the growth of Porphyromonas gingivalis by suppressing the expression of genes associated with DNA replication and cell division. Lasers Surg Med. 2012;44:856-64 pubmed publisher
    ..We therefore investigated the effect of blue LED irradiation on the growth of Porphyromonas gingivalis compared with the effects of red LED.
  57. Komatsu T, Nagano K, Sugiura S, Hagiwara M, Tanigawa N, Abiko Y, et al. E-selectin mediates Porphyromonas gingivalis adherence to human endothelial cells. Infect Immun. 2012;80:2570-6 pubmed publisher
    b>Porphyromonas gingivalis, a major periodontal pathogen, may contribute to atherogenesis and other inflammatory cardiovascular diseases. However, little is known about interactions between P. gingivalis and endothelial cells...
  58. Bostanci N, Belibasakis G. Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen. FEMS Microbiol Lett. 2012;333:1-9 pubmed publisher
    b>Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis, an inflammatory disease that destroys the tissues supporting the tooth, eventually leading to tooth loss...
  59. Feldman M, Grenier D. Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages. J Appl Microbiol. 2012;113:438-47 pubmed publisher
    ..aim of our study was to investigate whether two natural compounds, A-type cranberry proanthocyanidins (AC-PACs) and licochalcone A, act in synergy against Porphyromonas gingivalis and the host inflammatory response of a macrophage model.
  60. Glew M, Veith P, Peng B, Chen Y, Gorasia D, Yang Q, et al. PG0026 is the C-terminal signal peptidase of a novel secretion system of Porphyromonas gingivalis. J Biol Chem. 2012;287:24605-17 pubmed publisher
    Protein substrates of a novel secretion system of Porphyromonas gingivalis contain a conserved C-terminal domain (CTD) of ?70-80 amino acid residues that is essential for their secretion and attachment to the cell surface...
  61. Yamaguchi M, Noiri Y, Kuboniwa M, Yamamoto R, Asahi Y, Maezono H, et al. Porphyromonas gingivalis biofilms persist after chlorhexidine treatment. Eur J Oral Sci. 2013;121:162-8 pubmed publisher
    Chlorhexidine (CHX) gluconate effectively reduces the viability of biofilm-forming bacteria, such as Porphyromonas gingivalis. However, it is impossible to completely remove biofilms...
  62. Bostanci N, Belibasakis G. Doxycycline inhibits TREM-1 induction by Porphyromonas gingivalis. FEMS Immunol Med Microbiol. 2012;66:37-44 pubmed publisher
    ..b>Porphyromonas gingivalis is a Gram-negative anaerobic species highly implicated in inflammatory periodontal disease, with ..
  63. Lappin D, Apatzidou D, Quirke A, Oliver Bell J, Butcher J, Kinane D, et al. Influence of periodontal disease, Porphyromonas gingivalis and cigarette smoking on systemic anti-citrullinated peptide antibody titres. J Clin Periodontol. 2013;40:907-15 pubmed publisher
    Anti-citrullinated protein antibody (ACPA) responses may precede clinical onset of rheumatoid arthritis. Porphyromonas gingivalis peptidylarginine deiminase can citrullinate proteins possibly inducing autoimmunity in susceptible ..
  64. Gmiterek A, Wojtowicz H, Mackiewicz P, Radwan Oczko M, Kantorowicz M, Chomyszyn Gajewska M, et al. The unique hmuY gene sequence as a specific marker of Porphyromonas gingivalis. PLoS ONE. 2013;8:e67719 pubmed publisher
    b>Porphyromonas gingivalis, a major etiological agent of chronic periodontitis, acquires heme from host hemoproteins using the HmuY hemophore. The aim of this study was to develop a specific P...
  65. Madrigal A, Barth K, Papadopoulos G, Genco C. Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells. PLoS Pathog. 2012;8:e1002723 pubmed publisher
    b>Porphyromonas gingivalis is the primary etiologic agent of periodontal disease that is associated with other human chronic inflammatory diseases, including atherosclerosis. The ability of P...
  66. Takeuchi H, Hirano T, Whitmore S, Morisaki I, Amano A, Lamont R. The serine phosphatase SerB of Porphyromonas gingivalis suppresses IL-8 production by dephosphorylation of NF-?B RelA/p65. PLoS Pathog. 2013;9:e1003326 pubmed publisher
    b>Porphyromonas gingivalis is a major pathogen in severe and chronic manifestations of periodontal disease, which is one of the most common infections of humans. A central feature of P...
  67. Xie H, Zheng C. OxyR activation in Porphyromonas gingivalis in response to a hemin-limited environment. Infect Immun. 2012;80:3471-80 pubmed publisher
    b>Porphyromonas gingivalis is a Gram-negative obligately anaerobic bacterium associated with several forms of periodontal disease, most closely with chronic periodontitis...
  68. Cugini C, Stephens D, Nguyen D, Kantarci A, Davey M. Arginine deiminase inhibits Porphyromonas gingivalis surface attachment. Microbiology. 2013;159:275-85 pubmed publisher
    ..ADI) produced by Streptococcus intermedius that inhibited biofilm development of the commensal pathogen Porphyromonas gingivalis through downregulation of genes encoding the major (fimA) and minor (mfa1) fimbriae, both of which are ..
  69. Takasaki K, Fujise O, Miura M, Hamachi T, Maeda K. Porphyromonas gingivalis displays a competitive advantage over Aggregatibacter actinomycetemcomitans in co-cultured biofilm. J Periodontal Res. 2013;48:286-92 pubmed publisher
    ..b>Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans are important periodontal pathogens...
  70. Yamamoto R, Noiri Y, Yamaguchi M, Asahi Y, Maezono H, Kuboniwa M, et al. The sinR ortholog PGN_0088 encodes a transcriptional regulator that inhibits polysaccharide synthesis in Porphyromonas gingivalis ATCC 33277 biofilms. PLoS ONE. 2013;8:e56017 pubmed publisher
    ..b>Porphyromonas gingivalis inhabits the subgingival and extraradicular biofilm of humans and is one of the primary pathogens that ..
  71. Byrne D, Potempa J, Olczak T, Smalley J. Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermedia. Mol Oral Microbiol. 2013;28:219-29 pubmed publisher
    ..IX) is both an essential growth factor and a virulence regulator of the periodontal pathogens Porphyromonas gingivalis and Prevotella intermedia, which acquire it through the proteolytic degradation of haemoglobin and other ..
  72. Herath T, Darveau R, Seneviratne C, Wang C, Wang Y, Jin L. Tetra- and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-?B signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts. PLoS ONE. 2013;8:e58496 pubmed publisher
    b>Porphyromonas gingivalis is a major pathogen of periodontal disease that affects a majority of adults worldwide...
  73. Jeong E, Lee J, Kim S, Choi J. Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases. J Periodontal Res. 2012;47:811-6 pubmed publisher
    ..and rheumatoid arthritis, can be triggered and aggravated by the pathogen-driven antigenic peptide from Porphyromonas gingivalis HSP60. P...
  74. McLean J, Lombardo M, Ziegler M, Novotny M, Yee Greenbaum J, Badger J, et al. Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform. Genome Res. 2013;23:867-77 pubmed publisher
    ..focus on the recovery of a nearly complete genome representing a novel strain of the periodontal pathogen Porphyromonas gingivalis (P. gingivalis JCVI SC001) using the single-cell assembly tool SPAdes...
  75. Pyrc K, Milewska A, Kantyka T, Sroka A, Maresz K, Kozieł J, et al. Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage. Infect Immun. 2013;81:55-64 pubmed publisher
    b>Porphyromonas gingivalis is a Gram-negative bacterium associated with the development of periodontitis...
  76. Van Hemert J, Recker E, Dietrich D, Progulske Fox A, Kurago Z, Walters K, et al. Human ?-defensin-3 alters, but does not inhibit, the binding of Porphyromonas gingivalis haemagglutinin B to the surface of human dendritic cells. Int J Antimicrob Agents. 2012;40:75-9 pubmed publisher
    ..binds to many microbial antigens and, in this study, we hypothesised that the known binding of HBD3 to Porphyromonas gingivalis recombinant haemagglutinin B (rHagB) alters, but does not inhibit, the binding of rHagB to human ..
  77. Saadi Thiers K, Huck O, Simonis P, Tilly P, Fabre J, Tenenbaum H, et al. Periodontal and systemic responses in various mice models of experimental periodontitis: respective roles of inflammation duration and Porphyromonas gingivalis infection. J Periodontol. 2013;84:396-406 pubmed publisher
    ..This study compared the effect of Porphyromonas gingivalis (Pg) infection and experimental periodontitis duration at local and systemic levels in various models.
  78. Shoji M, Yukitake H, Sato K, Shibata Y, Naito M, Aduse Opoku J, et al. Identification of an O-antigen chain length regulator, WzzP, in Porphyromonas gingivalis. Microbiologyopen. 2013;2:383-401 pubmed publisher
    The periodontal pathogen Porphyromonas gingivalis has two different lipopolysaccharides (LPSs) designated O-LPS and A-LPS, which are a conventional O-antigen polysaccharide and an anionic polysaccharide that are both linked to lipid A-..
  79. Nagano K, Hasegawa Y, Abiko Y, Yoshida Y, Murakami Y, Yoshimura F. Porphyromonas gingivalis FimA fimbriae: fimbrial assembly by fimA alone in the fim gene cluster and differential antigenicity among fimA genotypes. PLoS ONE. 2012;7:e43722 pubmed publisher
    The periodontal pathogen Porphyromonas gingivalis colonizes largely through FimA fimbriae, composed of polymerized FimA encoded by fimA...
  80. Rangarajan M, Aduse Opoku J, Hashim A, Paramonov N, Curtis M. Characterization of the ?- and ?-mannosidases of Porphyromonas gingivalis. J Bacteriol. 2013;195:5297-307 pubmed publisher
    Mannose is an important sugar in the biology of the Gram-negative bacterium Porphyromonas gingivalis. It is a major component of the oligosaccharides attached to the Arg-gingipain cysteine proteases, the repeating units of an acidic ..
  81. Wojtowicz H, Bielecki M, Wojaczyński J, Olczak M, Smalley J, Olczak T. The Porphyromonas gingivalis HmuY haemophore binds gallium(iii), zinc(ii), cobalt(iii), manganese(iii), nickel(ii), and copper(ii) protoporphyrin IX but in a manner different to iron(iii) protoporphyrin IX. Metallomics. 2013;5:343-51 pubmed publisher
    b>Porphyromonas gingivalis, a major etiological agent of chronic periodontitis, acquires haem from host haemoproteins through a haem transporter HmuR and a haemophore HmuY...
  82. McKenzie R, Johnson N, Aruni W, Dou Y, Masinde G, Fletcher H. Differential response of Porphyromonas gingivalis to varying levels and duration of hydrogen peroxide-induced oxidative stress. Microbiology. 2012;158:2465-79 pubmed
    b>Porphyromonas gingivalis, an anaerobic oral pathogen implicated in adult periodontitis, can exist in an environment of oxidative stress. To evaluate its adaptation to this environment, we have assessed the response of P...
  83. Biyikoğlu B, Ricker A, Diaz P. Strain-specific colonization patterns and serum modulation of multi-species oral biofilm development. Anaerobe. 2012;18:459-70 pubmed publisher
    ..subgingivally prevalent microorganism Fusobacterium nucleatum and four strains of the periodontopathogen Porphyromonas gingivalis. We also tested the effect of serum, which resembles gingival exudates, on subgingival biofilms...
  84. Liu Y, Zhang Y, Wang L, Guo Y, Xiao S. Prevalence of Porphyromonas gingivalis four rag locus genotypes in patients of orthodontic gingivitis and periodontitis. PLoS ONE. 2013;8:e61028 pubmed publisher
    b>Porphyromonas gingivalis is considered as a major etiological agent in periodontal diseases and implied to result in gingival inflammation under orthodontic appliance. rag locus is a pathogenicity island found in Porphyromonas gingivalis...
  85. Reddi D, Belibasakis G. Transcriptional profiling of bone marrow stromal cells in response to Porphyromonas gingivalis secreted products. PLoS ONE. 2012;7:e43899 pubmed publisher
    ..b>Porphyromonas gingivalis is an oral pathogen highly implicated in the pathogenesis of this disease...
  86. Abdullah S, Farmer E, Spargo L, Logan R, Gully N. Porphyromonas gingivalis peptidylarginine deiminase substrate specificity. Anaerobe. 2013;23:102-8 pubmed publisher
    ..have been implicated in the aetiology of chronic periodontitis; the asaccharolytic Gram negative anaerobe Porphyromonas gingivalis is most commonly reported to be associated with severe forms of the disease...
  87. Muthiah A, Aruni W, Robles A, Dou Y, Roy F, Fletcher H. In Porphyromonas gingivalis VimF is involved in gingipain maturation through the transfer of galactose. PLoS ONE. 2013;8:e63367 pubmed publisher
    Previously, we have reported that gingipain activity in Porphyromonas gingivalis, the major causative agent in adult periodontitis, is post-translationally regulated by the unique Vim proteins including VimF, a putative ..
  88. Wayakanon K, Thornhill M, Douglas C, Lewis A, Warren N, Pinnock A, et al. Polymersome-mediated intracellular delivery of antibiotics to treat Porphyromonas gingivalis-infected oral epithelial cells. FASEB J. 2013;27:4455-65 pubmed publisher
    The gram-negative anaerobe Porphyromonas gingivalis colonizes the gingival crevice and is etiologically associated with periodontal disease that can lead to alveolar bone damage and resorption, promoting tooth loss...
  89. Shanker J, Setty P, Arvind P, Nair J, Bhasker D, Balakrishna G, et al. Relationship between periodontal disease, Porphyromonas gingivalis, peripheral vascular resistance markers and coronary artery disease in Asian Indians. Thromb Res. 2013;132:e8-14 pubmed publisher
    ..We examined the interrelationship between Periodontal disease, oral bacteria, surrogate sub-clinical markers and coronary artery disease (CAD) in a representative Asian Indian cohort...
  90. Khalaf H, Bengtsson T. Altered T-cell responses by the periodontal pathogen Porphyromonas gingivalis. PLoS ONE. 2012;7:e45192 pubmed publisher
    ..inflammatory diseases periodontitis and atherosclerosis with a crucial role for the periodontal pathogen Porphyromonas gingivalis. However, the interplay between this pathogen and the adaptive immune system, including T-cells, is ..
  91. Turunen S, Kummu O, Harila K, Veneskoski M, Soliymani R, Baumann M, et al. Recognition of Porphyromonas gingivalis gingipain epitopes by natural IgM binding to malondialdehyde modified low-density lipoprotein. PLoS ONE. 2012;7:e34910 pubmed publisher
    ..We aimed to identify epitopes on periodontal pathogen Porphyromonas gingivalis recognized by natural IgM binding to malondialdehyde (MDA) modified LDL.
  92. Hajishengallis G, Lamont R. Breaking bad: manipulation of the host response by Porphyromonas gingivalis. Eur J Immunol. 2014;44:328-38 pubmed publisher
    ..the development of dysbiosis are now known as keystone pathogens, the best-documented example of which is Porphyromonas gingivalis. Here, we review established mechanisms by which P...
  93. Park Y, Kim Y, Jung Y, Lee S, Lee Y, Bang J, et al. Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells. Cytokine. 2012;60:284-93 pubmed publisher
    ..The aim of this study was to explore the role of SIRT1 signaling on Porphyromonas gingivalis lipopolysaccharide (LPS)-induced IL-17 and IL-23 production in human periodontal ligament cells (hPDLCs)...
  94. Aruni A, Robles A, Fletcher H. VimA mediates multiple functions that control virulence in Porphyromonas gingivalis. Mol Oral Microbiol. 2013;28:167-80 pubmed publisher
    b>Porphyromonas gingivalis, a black-pigmented, gram-negative anaerobe, is an important etiological agent of periodontal disease...