bacteroides thetaiotaomicron


Summary: A species of Bacteroides that is a major constituent of the human GUT MICROBIOTA. It normally produces enzymes important for the digestion of vegetable matter. However, it can also cause OPPORTUNISTIC INFECTIONS that result in intra-abdominal SEPSIS; BACTEREMIA; and PERITONITIS.

Top Publications

  1. Ndeh D, Rogowski A, Cartmell A, Luís A, Baslé A, GRAY J, et al. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature. 2017;544:65-70 pubmed publisher
    ..Here we show that the gut bacterium Bacteroides thetaiotaomicron uses the most structurally complex glycan known: the plant pectic polysaccharide rhamnogalacturonan-II, ..
  2. Robinson L, Lewis W, Lewis A. The sialate O-acetylesterase EstA from gut Bacteroidetes species enables sialidase-mediated cross-species foraging of 9-O-acetylated sialoglycans. J Biol Chem. 2017;292:11861-11872 pubmed publisher
    ..We conclude that EstA specifically unlocks the nutritive potential of 9-O-acetylated mucus sialic acids for foraging by bacteria that otherwise are prevented from accessing this carbon source. ..
  3. Liu R, Hong J, Xu X, Feng Q, Zhang D, Gu Y, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med. 2017;23:859-868 pubmed publisher
    ..The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely ..
  4. Munoz Munoz J, Cartmell A, Terrapon N, Basle A, Henrissat B, Gilbert H. An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins. J Biol Chem. 2017;292:13271-13283 pubmed publisher
    ..we screened the potential enzymatic functions of hypothetical proteins encoded by genes of Bacteroides thetaiotaomicron that were up-regulated by arabinogalactan proteins or AGPs...