bacteroides fragilis

Summary

Summary: Gram-negative bacteria occurring in the lower intestinal tracts of man and other animals. It is the most common species of anaerobic bacteria isolated from human soft tissue infections.

Top Publications

  1. Coyne M, Reinap B, Lee M, Comstock L. Human symbionts use a host-like pathway for surface fucosylation. Science. 2005;307:1778-81 pubmed
    ..A Bacteroides mutant deficient in the ability to cover its surface with L-fucose is defective in colonizing the mammalian intestine under competitive conditions. ..
  2. Hawkins S, Layton A, Ripp S, Williams D, Sayler G. Genome sequence of the Bacteroides fragilis phage ATCC 51477-B1. Virol J. 2008;5:97 pubmed publisher
    The genome of a fecal pollution indicator phage, Bacteroides fragilis ATCC 51477-B1, was sequenced and consisted of 44,929 bases with a G+C content of 38.7%...
  3. Tong J, Liu C, Summanen P, Xu H, Finegold S. Application of quantitative real-time PCR for rapid identification of Bacteroides fragilis group and related organisms in human wound samples. Anaerobe. 2011;17:64-8 pubmed publisher
    Our goal was to establish a quantitative real-time PCR (QRT-PCR) method to detect Bacteroides fragilis group and related organisms from clinical specimens...
  4. Shi D, Morizono H, Cabrera Luque J, Yu X, Roth L, Malamy M, et al. Structure and catalytic mechanism of a novel N-succinyl-L-ornithine transcarbamylase in arginine biosynthesis of Bacteroides fragilis. J Biol Chem. 2006;281:20623-31 pubmed
    A Bacteroides fragilis gene (argF'(bf)), the disruption of which renders the bacterium auxotrophic for arginine, was expressed and its recombinant protein purified and studied...
  5. Nagy E, Becker S, Sóki J, Urban E, Kostrzewa M. Differentiation of division I (cfiA-negative) and division II (cfiA-positive) Bacteroides fragilis strains by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Med Microbiol. 2011;60:1584-90 pubmed publisher
    ..The cfiA gene encoding the unique carbapenemases found in Bacteroides is restricted to division II Bacteroides fragilis strains. The aim of this study was to evaluate whether MALDI-TOF MS is suitable for differentiating B...
  6. Bennett M, McKnight S, Coleman J. Cloning and characterization of the NAD-dependent 7alpha-Hydroxysteroid dehydrogenase from Bacteroides fragilis. Curr Microbiol. 2003;47:475-84 pubmed
    The NAD-linked 7alpha-hydroxysteroid dehydrogenase (7-HSDH) from Bacteroides fragilis ATCC 25285 was characterized and its gene cloned. The enzyme displayed optimal activities at pH 8.5 (NAD reduction) and 6.5 (NADH oxidation)...
  7. Schaumann R, Petzold S, Fille M, Rodloff A. Inducible metronidazole resistance in nim-positive and nim-negative bacteroides fragilis group strains after several passages metronidazole containing columbia agar plates. Infection. 2005;33:368-72 pubmed
    Recent data show an emergence of resistance in the Bacteroides fragilis group against several antimicrobial agents and inducible resistance against metronidazole in nim-positive strains...
  8. Patrick S, Houston S, Thacker Z, Blakely G. Mutational analysis of genes implicated in LPS and capsular polysaccharide biosynthesis in the opportunistic pathogen Bacteroides fragilis. Microbiology. 2009;155:1039-49 pubmed publisher
    The obligate anaerobe Bacteroides fragilis is a normal resident of the human gastrointestinal tract. The clinically derived B...
  9. Ryan S, Bonomo J, Zhao F, Cobb B. MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation. J Exp Med. 2011;208:1041-53 pubmed publisher
    ..reduced MHCII binding and presentation of the T cell activating glycoantigen (GlyAg) polysaccharide A from Bacteroides fragilis but not conventional peptides...

More Information

Publications131 found, 100 shown here

  1. Park H, Brothers E, Merz K. Hybrid QM/MM and DFT investigations of the catalytic mechanism and inhibition of the dinuclear zinc metallo-beta-lactamase CcrA from Bacteroides fragilis. J Am Chem Soc. 2005;127:4232-41 pubmed
    ..the mechanistic and energetic features of the catalytic action of dizinc metallo-beta-lactamase CcrA from Bacteroides fragilis. The 200 ps QM/MM simulation of the CcrA enzyme in complex with nitrocefin shows that the substrate beta-..
  2. Ayala J, Quesada A, Vadillo S, Criado J, P riz S. Penicillin-binding proteins of Bacteroides fragilis and their role in the resistance to imipenem of clinical isolates. J Med Microbiol. 2005;54:1055-64 pubmed publisher
    In this study penicillin-binding proteins (PBPs) of Bacteroides fragilis and the resistance mechanisms of this micro-organism to 11 beta-lactam antibiotics were analysed...
  3. Casanueva A, Paul L, Patrick S, Abratt V. An AraC/XylS family transcriptional regulator homologue from Bacteroides fragilis is associated with cell survival following DNA damage. FEMS Microbiol Lett. 2008;278:249-56 pubmed
    A putative transcriptional regulator of the AraC/XylS family was identified in a genomic genebank of Bacteroides fragilis Bf-1, which partially relieved the sensitivity of Escherichia coli DNA repair mutants to the DNA-damaging agents, ..
  4. Brigham C, Caughlan R, Gallegos R, Dallas M, Godoy V, Malamy M. Sialic acid (N-acetyl neuraminic acid) utilization by Bacteroides fragilis requires a novel N-acetyl mannosamine epimerase. J Bacteriol. 2009;191:3629-38 pubmed publisher
    We characterized the nanLET operon in Bacteroides fragilis, whose products are required for the utilization of the sialic acid N-acetyl neuraminic acid (NANA) as a carbon and energy source...
  5. Wybo I, De Bel A, Soetens O, Echahidi F, Vandoorslaer K, Van Cauwenbergh M, et al. Differentiation of cfiA-negative and cfiA-positive Bacteroides fragilis isolates by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol. 2011;49:1961-4 pubmed publisher
    Carbapenem resistance in Bacteroides fragilis is associated with cfiA-encoded class B metallo-beta-lactamase. cfiA-negative and cfiA-positive isolates belong to genotypically distinct groups. Of a total of 248 B...
  6. Sanchez E, Laparra J, Sanz Y. Discerning the role of Bacteroides fragilis in celiac disease pathogenesis. Appl Environ Microbiol. 2012;78:6507-15 pubmed publisher
    ..The proteolytic activity of selected Bacteroides fragilis strains was evaluated by zymography and, after gastrointestinal digestion of gliadin, by high-pressure ..
  7. Kim J, Jung H, Lee J, Youn J, Lee C, Kim K. Mitogen-activated protein kinase and activator protein-1 dependent signals are essential for Bacteroides fragilis enterotoxin-induced enteritis. Eur J Immunol. 2005;35:2648-57 pubmed
    The approximately 20-kDa heat-labile toxin produced by enterotoxigenic Bacteroides fragilis is known to be associated with the development of enteritis. However, the molecular mechanism involved is not yet fully understood...
  8. Betriu C, Culebras E, Gomez M, Lopez F, Rodriguez Avial I, Picazo J. Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. Antimicrob Agents Chemother. 2008;52:2686-90 pubmed publisher
    The changes in susceptibilities of Bacteroides fragilis group strains isolated in our hospital from 1997 to 2006 were studied. A total of 1,343 clinical strains were included...
  9. Coyne M, Chatzidaki Livanis M, Paoletti L, Comstock L. Role of glycan synthesis in colonization of the mammalian gut by the bacterial symbiont Bacteroides fragilis. Proc Natl Acad Sci U S A. 2008;105:13099-104 pubmed publisher
    ..We previously showed that a Bacteroides fragilis mutant unable to synthesize 4 of the 8 capsular polysaccharides and unable to glycosylate proteins properly ..
  10. Tsuji Y, Okita Y, Niwaya K, Tsukube T, Doita M, Marui T, et al. Allograft replacement of common iliac artery mycotic aneurysm caused by Bacteroides fragilis vertebral spondylitis--a case report. Vasc Endovascular Surg. 2003;37:441-4 pubmed
    ..The postoperative course was uneventful, and he remains well 3 years after his operation without persistent infection or allograft rejection...
  11. Sóki J, Fodor E, Hecht D, Edwards R, Rotimi V, Kerekes I, et al. Molecular characterization of imipenem-resistant, cfiA-positive Bacteroides fragilis isolates from the USA, Hungary and Kuwait. J Med Microbiol. 2004;53:413-9 pubmed
    Fifteen Bacteroides fragilis isolates from the USA, Hungary and Kuwait were examined for carbapenem resistance, for carbapenemase activity and, with the use of various PCR-based methods and nucleotide sequencing, for cfiA genes and ..
  12. de O Ferreira E, Araújo Lobo L, Barreiros Petrópolis D, dos S Avelar K, Ferreira M, e Silva Filho F, et al. A Bacteroides fragilis surface glycoprotein mediates the interaction between the bacterium and the extracellular matrix component laminin-1. Res Microbiol. 2006;157:960-6 pubmed
    The adherence of Bacteroides fragilis strains to immobilized laminin-1 (LMN-1) was investigated using this protein adsorbed onto glass...
  13. Chatzidaki Livanis M, Coyne M, Comstock L. A family of transcriptional antitermination factors necessary for synthesis of the capsular polysaccharides of Bacteroides fragilis. J Bacteriol. 2009;191:7288-95 pubmed publisher
    A single strain of Bacteroides fragilis synthesizes eight distinct capsular polysaccharides, designated PSA to PSH. These polysaccharides are synthesized by-products encoded by eight separate polysaccharide biosynthesis loci...
  14. Chatzidaki Livanis M, Weinacht K, Comstock L. Trans locus inhibitors limit concomitant polysaccharide synthesis in the human gut symbiont Bacteroides fragilis. Proc Natl Acad Sci U S A. 2010;107:11976-80 pubmed publisher
    ..b>Bacteroides fragilis, for example, synthesizes eight capsular polysaccharides per strain, each of which phase varies via ..
  15. Lee Y, Park Y, Kim M, Yong D, Jeong S, Lee K, et al. Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. Antimicrob Agents Chemother. 2010;54:3993-7 pubmed publisher
    ..The rates of resistance of Bacteroides fragilis group organisms and anaerobic gram-positive cocci to moxifloxacin were 11 to 18% and 0 to 27%, respectively.
  16. Wick E, Sears C. Bacteroides spp. and diarrhea. Curr Opin Infect Dis. 2010;23:470-4 pubmed publisher
    ..The purpose of this review is to describe recent progress in the understanding of the role of Bacteroides spp. in human diarrheal diseases and newer murine studies implicating certain Bacteroides spp. in colorectal cancer...
  17. Fletcher C, Coyne M, Comstock L. Theoretical and experimental characterization of the scope of protein O-glycosylation in Bacteroides fragilis. J Biol Chem. 2011;286:3219-26 pubmed publisher
    Among bacterial species demonstrated to have protein O-glycosylation systems, that of Bacteroides fragilis and related species is unique in that extracytoplasmic proteins are glycosylated at serine or threonine residues within the ..
  18. Franco A. The Bacteroides fragilis pathogenicity island is contained in a putative novel conjugative transposon. J Bacteriol. 2004;186:6077-92 pubmed publisher
    The genetic element flanking the Bacteroides fragilis pathogenicity island (BfPAI) in enterotoxigenic B. fragilis (ETBF) strain 86-5443-2-2 and a related genetic element in NCTC 9343 were characterized...
  19. Walsh T, Onken A, Haldorsen B, Toleman M, Sundsfjord A. Characterization of a carbapenemase-producing clinical isolate of Bacteroides fragilis in Scandinavia: genetic analysis of a unique insertion sequence. Scand J Infect Dis. 2005;37:676-9 pubmed
    In 2003 a Bacteroides fragilis blood culture isolate (K2-28) was recovered from a 61-y-old male with severe general atherosclerosis during treatment with meropenem...
  20. Pumbwe L, Ueda O, Yoshimura F, Chang A, Smith R, Wexler H. Bacteroides fragilis BmeABC efflux systems additively confer intrinsic antimicrobial resistance. J Antimicrob Chemother. 2006;58:37-46 pubmed
    To determine the prevalence of expression and function(s) of Bacteroides fragilis RND family efflux transport systems (bmeABC1-16)...
  21. Reott M, Parker A, Rocha E, Smith C. Thioredoxins in redox maintenance and survival during oxidative stress of Bacteroides fragilis. J Bacteriol. 2009;191:3384-91 pubmed publisher
    The anaerobe Bacteroides fragilis is a gram-negative, opportunistic pathogen that is highly aerotolerant and can persist in aerobic environments for extended periods. In this study, the six B...
  22. Ochoa Reparaz J, Mielcarz D, Wang Y, Begum Haque S, DasGupta S, Kasper D, et al. A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunol. 2010;3:487-95 pubmed publisher
    ..We now show that a zwitterionic capsular polysaccharide A (PSA) of Bacteroides fragilis can protect against central nervous system demyelinating disease...
  23. Wareham D, Wilks M, Ahmed D, Brazier J, Millar M. Anaerobic sepsis due to multidrug-resistant Bacteroides fragilis: microbiological cure and clinical response with linezolid therapy. Clin Infect Dis. 2005;40:e67-8 pubmed
    We describe the first reported case of anaerobic sepsis due to Bacteroides fragilis with simultaneous resistance to metronidazole, beta-lactams, beta lactam/beta-lactamase inhibitors, carbapenems, macrolides, and tetracyclines...
  24. Reuter M, Parry F, Dryden D, Blakely G. Single-molecule imaging of Bacteroides fragilis AddAB reveals the highly processive translocation of a single motor helicase. Nucleic Acids Res. 2010;38:3721-31 pubmed publisher
    ..Here, we show that AddAB, from the Gram-negative opportunistic pathogen Bacteroides fragilis, can rescue the ultraviolet sensitivity of an Escherichia coli recBCD mutant and that addAB is required for ..
  25. Patrick S, Blakely G, Houston S, Moore J, Abratt V, Bertalan M, et al. Twenty-eight divergent polysaccharide loci specifying within- and amongst-strain capsule diversity in three strains of Bacteroides fragilis. Microbiology. 2010;156:3255-69 pubmed publisher
    Comparison of the complete genome sequence of Bacteroides fragilis 638R, originally isolated in the USA, was made with two previously sequenced strains isolated in the UK (NCTC 9343) and Japan (YCH46)...
  26. Avila Campos M, Liu C, Song Y, Rowlinson M, Finegold S. Determination of bft gene subtypes in Bacteroides fragilis clinical isolates. J Clin Microbiol. 2007;45:1336-8 pubmed
    A rapid multiplex PCR approach was developed to detect the bft gene subtypes in Bacteroides fragilis clinical isolates. This technique could be used to look at the epidemiology of enterotoxigenic strains of B...
  27. RABIZADEH S, Rhee K, Wu S, Huso D, Gan C, Golub J, et al. Enterotoxigenic bacteroides fragilis: a potential instigator of colitis. Inflamm Bowel Dis. 2007;13:1475-83 pubmed
    ..Enterotoxigenic Bacteroides fragilis (ETBF), a molecular subclass of the common human commensal, B. fragilis, has been associated with IBD...
  28. Jiang Z, DuPont H, Brown E, Nandy R, Ramamurthy T, Sinha A, et al. Microbial etiology of travelers' diarrhea in Mexico, Guatemala, and India: importance of enterotoxigenic Bacteroides fragilis and Arcobacter species. J Clin Microbiol. 2010;48:1417-9 pubmed publisher
    This study examined established enteric pathogens, Arcobacter species and enterotoxigenic Bacteroides fragilis (ETBF), in 201 U.S. and European travelers with acute diarrhea acquired in Mexico, Guatemala, and India...
  29. Snydman D, Jacobus N, McDermott L, Ruthazer R, Golan Y, Goldstein E, et al. National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997 to 2004. Antimicrob Agents Chemother. 2007;51:1649-55 pubmed
    The susceptibility trends for the species of the Bacteroides fragilis group against various antibiotics from 1997 to 2004 were determined by using data for 5,225 isolates referred by 10 medical centers...
  30. Pumbwe L, Wareham D, Aduse Opoku J, Brazier J, Wexler H. Genetic analysis of mechanisms of multidrug resistance in a clinical isolate of Bacteroides fragilis. Clin Microbiol Infect. 2007;13:183-9 pubmed
    This study investigated the mechanisms of multidrug resistance (MDR) in an isolate of Bacteroides fragilis (WI1) from a patient with anaerobic sepsis...
  31. Fletcher C, Coyne M, Villa O, Chatzidaki Livanis M, Comstock L. A general O-glycosylation system important to the physiology of a major human intestinal symbiont. Cell. 2009;137:321-31 pubmed publisher
    ..Here, we demonstrate that Bacteroides fragilis has a general O-glycosylation system...
  32. Meehan B, Malamy M. Fumarate reductase is a major contributor to the generation of reactive oxygen species in the anaerobe Bacteroides fragilis. Microbiology. 2012;158:539-46 pubmed publisher
    ..by the presence of efficient ROS-scavenging pathways, like those found in the aerotolerant anaerobe Bacteroides fragilis. Here we demonstrate that deletion of the genes encoding catalase (Kat), alkylhydroperoxide reductase (AhpC)..
  33. Surana N, Kasper D. The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA. Immunol Rev. 2012;245:13-26 pubmed publisher
    ..In this review, we discuss the immunomodulatory effects of the archetypal ZPS, Bacteroides fragilis PSA...
  34. Galvão B, Meggersee R, Abratt V. Antibiotic resistance and adhesion potential of Bacteroides fragilis clinical isolates from Cape Town, South Africa. Anaerobe. 2011;17:142-6 pubmed publisher
    The minimum inhibitory concentrations of 23 Bacteroides fragilis clinical isolates from Cape Town, South Africa, were established using the E-test method...
  35. Nakayama Imaohji H, Hirakawa H, Ichimura M, Wakimoto S, Kuhara S, Hayashi T, et al. Identification of the site-specific DNA invertase responsible for the phase variation of SusC/SusD family outer membrane proteins in Bacteroides fragilis. J Bacteriol. 2009;191:6003-11 pubmed publisher
    The human gut microbe Bacteroides fragilis can alter the expression of its surface molecules, such as capsular polysaccharides and SusC/SusD family outer membrane proteins, through reversible DNA inversions...
  36. Cohen S, Shetab R, Tang Feldman Y, Sarma P, Silva J, Prindiville T. Prevalence of enterotoxigenic Bacteroides fragilis in hospital-acquired diarrhea. Diagn Microbiol Infect Dis. 2006;55:251-4 pubmed
    ..specimens from 152 hospitalized patients with diarrhea were analyzed for the presence of enterotoxigenic Bacteroides fragilis (ETBF) by a nested polymerase chain reaction (PCR) assay...
  37. Rocha E, Tzianabos A, Smith C. Thioredoxin reductase is essential for thiol/disulfide redox control and oxidative stress survival of the anaerobe Bacteroides fragilis. J Bacteriol. 2007;189:8015-23 pubmed
    Results of this study showed that the anaerobic, opportunistic pathogen Bacteroides fragilis lacks the glutathione/glutaredoxin redox system and possesses an extensive number of putative thioredoxin (Trx) orthologs...
  38. Ochoa Reparaz J, Mielcarz D, Ditrio L, Burroughs A, Begum Haque S, Dasgupta S, et al. Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression. J Immunol. 2010;185:4101-8 pubmed publisher
    ..our previous observations on the role of commensal bacteria in CNS demyelination, and we demonstrate that Bacteroides fragilis producing a bacterial capsular polysaccharide Ag can protect against EAE. Recolonization with wild type B...
  39. Paula G, Falcão L, Antunes E, Avelar K, Reis F, Maluhy M, et al. Determinants of resistance in Bacteroides fragilis strains according to recent Brazilian profiles of antimicrobial susceptibility. Int J Antimicrob Agents. 2004;24:53-8 pubmed
    Susceptibility profiles of 99 Bacteroides fragilis strains for 9 antimicrobial agents were defined by using an agar dilution method. The isolates were uniformly susceptible to imipenen and metronidazole...
  40. Matsuki T, Watanabe K, Fujimoto J, Takada T, Tanaka R. Use of 16S rRNA gene-targeted group-specific primers for real-time PCR analysis of predominant bacteria in human feces. Appl Environ Microbiol. 2004;70:7220-8 pubmed
    ..specific primers together with four sets of group-specific primers for the Clostridium coccoides group, the Bacteroides fragilis group, Bifidobacterium, and Prevotella developed in a previous study (T. Matsuki, K. Watanabe, J...
  41. Pathela P, Hasan K, Roy E, Alam K, Huq F, Siddique A, et al. Enterotoxigenic Bacteroides fragilis-associated diarrhea in children 0-2 years of age in rural Bangladesh. J Infect Dis. 2005;191:1245-52 pubmed
    The burden of enterotoxigenic Bacteroides fragilis (ETBF)-related diarrhea was determined in a birth cohort of 252 children in rural Bangladesh...
  42. Buckwold S, Shoemaker N, Sears C, Franco A. Identification and characterization of conjugative transposons CTn86 and CTn9343 in Bacteroides fragilis strains. Appl Environ Microbiol. 2007;73:53-63 pubmed
    The related genetic elements flanking the Bacteroides fragilis pathogenicity island (PAI) in enterotoxigenic B. fragilis (ETBF) 86-5443-2-2 and also present in pattern III nontoxigenic B...
  43. Round J, Lee S, Li J, Tran G, Jabri B, Chatila T, et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science. 2011;332:974-7 pubmed publisher
    ..By contrast, we demonstrate that the prominent gut commensal Bacteroides fragilis activates the TLR pathway to establish host-microbial symbiosis. TLR2 on CD4(+) T cells is required for B...
  44. Kuwahara T, Yamashita A, Hirakawa H, Nakayama H, Toh H, Okada N, et al. Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation. Proc Natl Acad Sci U S A. 2004;101:14919-24 pubmed
    Bacteroides are predominant human colonic commensals, but the principal pathogenic species, Bacteroides fragilis (BF), lives closely associated with the mucosal surface, whereas a second major species, Bacteroides thetaiotaomicron (BT), ..
  45. Mancuso G, Midiri A, Biondo C, Beninati C, Gambuzza M, Macrì D, et al. Bacteroides fragilis-derived lipopolysaccharide produces cell activation and lethal toxicity via toll-like receptor 4. Infect Immun. 2005;73:5620-7 pubmed
    b>Bacteroides fragilis, which is part of the normal intestinal flora, is a frequent cause of serious disease, especially in diabetic and surgical patients. In these conditions, B...
  46. Nagy E, Urban E, Nord C. Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe: 20 years of experience. Clin Microbiol Infect. 2011;17:371-9 pubmed publisher
    The susceptibilities of 824 Bacteroides fragilis group isolates against nine antibiotics were evaluated in a Europe-wide study involving 13 countries. Species determination, by different methods, was carried out on all but one isolate...
  47. Seifert H, Dalhoff A. German multicentre survey of the antibiotic susceptibility of Bacteroides fragilis group and Prevotella species isolated from intra-abdominal infections: results from the PRISMA study. J Antimicrob Chemother. 2010;65:2405-10 pubmed publisher
  48. Sears C. In celebration of Sydney M. Finegold, M.D.: bacteroides fragilis in the colon: the good & the bad. Anaerobe. 2012;18:192-6 pubmed publisher
    ..and provides a perspective on the changes and growth in our understanding of one anaerobic species, Bacteroides fragilis. Over the last nearly 40 years, clinical and research data have fostered our current view that B...
  49. Weinacht K, Roche H, Krinos C, Coyne M, Parkhill J, Comstock L. Tyrosine site-specific recombinases mediate DNA inversions affecting the expression of outer surface proteins of Bacteroides fragilis. Mol Microbiol. 2004;53:1319-30 pubmed
    The chromosome of Bacteroides fragilis has been shown to undergo 13 distinct DNA inversions affecting the expression of capsular polysaccharides and mediated by a serine site-specific recombinase designated Mpi...
  50. Lee H, Liu K, Yang Y, Kan C. Bacteroides fragilis aortic arch pseudoaneurysm: case report with review. J Cardiothorac Surg. 2008;3:29 pubmed publisher
    ..with prosthetic graft interposition, all her blood cultures and tissue cultures revealed pathogen with Bacteroides fragilis. Although mycotic aneurysms have been well described in literatures, an aneurysm infected solely with ..
  51. Roh K, Kim S, Kim C, Yum J, Kim M, Yong D, et al. Resistance trends of Bacteroides fragilis group over an 8-year period, 1997-2004, in Korea. Korean J Lab Med. 2009;29:293-8 pubmed publisher
    b>Bacteroides fragilis group organisms are the most frequently isolated anaerobes in human infections...
  52. Round J, Mazmanian S. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A. 2010;107:12204-9 pubmed publisher
    ..We report herein that a prominent human commensal, Bacteroides fragilis, directs the development of Foxp3(+) regulatory T cells (Tregs) with a unique "inducible" genetic ..
  53. Basset C, Holton J, Bazeos A, Vaira D, Bloom S. Are Helicobacter species and enterotoxigenic Bacteroides fragilis involved in inflammatory bowel disease?. Dig Dis Sci. 2004;49:1425-32 pubmed
    ..In conclusion, Helicobacter was not associated with IBD in our population of patients, although ETBF may be associated with active disease. ..
  54. Vael C, Nelen V, Verhulst S, Goossens H, Desager K. Early intestinal Bacteroides fragilis colonisation and development of asthma. BMC Pulm Med. 2008;8:19 pubmed publisher
    ..Asthma Predictive Index was positive in 26/117 (22%) of the children. The prevalence of colonisation with Bacteroides fragilis was higher at 3 weeks in index+ compared to index- children (64% vs. 34% p < 0,05)...
  55. Medina C, Santana A, Llopis M, Paz Cabrera M, Antolin M, Mourelle M, et al. Induction of colonic transmural inflammation by Bacteroides fragilis: implication of matrix metalloproteinases. Inflamm Bowel Dis. 2005;11:99-105 pubmed
    ..We hypothesized that Bacteroides fragilis-produced metalloproteinases (MMPs) are responsible for bacterial migration through the intestinal wall and ..
  56. Ichimura M, Nakayama Imaohji H, Wakimoto S, Morita H, Hayashi T, Kuwahara T. Efficient electrotransformation of Bacteroides fragilis. Appl Environ Microbiol. 2010;76:3325-32 pubmed publisher
    This study describes refined electroporation parameters for efficient transformation of Bacteroides fragilis by plasmids prepared from laboratory strains of Escherichia coli...
  57. Brigham C, Malamy M. Characterization of the RokA and HexA broad-substrate-specificity hexokinases from Bacteroides fragilis and their role in hexose and N-acetylglucosamine utilization. J Bacteriol. 2005;187:890-901 pubmed publisher
    b>Bacteroides fragilis, a human gastrointestinal commensal and an opportunistic pathogen, utilizes simple and complex sugars and polysaccharides for growth in the large intestine and at sites of infection. Because B...
  58. Beland M, Soares G, Dubel G, Forte M, Murphy T. Endovascular repair of a thoracic aorta mycotic pseudoaneurysm in a patient with history of bacteroides fragilis sepsis and leprosy. J Vasc Interv Radiol. 2005;16:298-300 pubmed
  59. Almeida F, Nakano V, Avila Campos M. Occurrence of enterotoxigenic and nonenterotoxigenic Bacteroides fragilis in calves and evaluation of their antimicrobial susceptibility. FEMS Microbiol Lett. 2007;272:15-21 pubmed
    b>Bacteroides fragilis is considered an important clinical pathogen and the most common anaerobe isolated from human and animal clinical specimens; enterotoxigenic strains produce diarrhea...
  60. Cheng C, Lin H, Ye J, Yang C, Chiang P, Wu T, et al. Clinical significance of and outcomes for Bacteroides fragilis bacteremia. J Microbiol Immunol Infect. 2009;42:243-50 pubmed
    b>Bacteroides fragilis is a virulent anaerobic pathogen, resulting in considerable mortality. This study was conducted to investigate the clinical characteristics, significance of polymicrobial bacteremia, and treatment outcomes of B...
  61. Salsbury F, Crowder M, Kingsmore S, Huntley J. Molecular dynamic simulations of the metallo-beta-lactamase from Bacteroides fragilis in the presence and absence of a tight-binding inhibitor. J Mol Model. 2009;15:133-45 pubmed publisher
    ..changes that occur due to binding of an inhibitor to the dicanzinc metallo-beta-lactamase from Bacteroides fragilis. Our studies confirm previous findings that the major flap is a major source of plasticity within the ..
  62. Diniz C, Farias L, Carvalho M, Rocha E, Smith C. Differential gene expression in a Bacteroides fragilis metronidazole-resistant mutant. J Antimicrob Chemother. 2004;54:100-8 pubmed
    ..The current work focused on molecular changes in a spontaneous Bacteroides fragilismutant selected by low concentrations of metronidazole as an adaptive response to the drug...
  63. Snydman D, Jacobus N, McDermott L. Evaluation of the in vitro activity of NVP-LMB415 against clinical anaerobic isolates with emphasis on the Bacteroides fragilis group. J Antimicrob Chemother. 2005;55:1024-8 pubmed
    To compare the in vitro activity of NVP-LMB415 (formerly referred to as NVP-PDF 713) with that of other agents with anti-anaerobe activity against clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group.
  64. Rhee K, Wu S, Wu X, Huso D, Karim B, Franco A, et al. Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice. Infect Immun. 2009;77:1708-18 pubmed publisher
    Enterotoxigenic Bacteroides fragilis (ETBF) causes diarrhea and is implicated in inflammatory bowel diseases and colorectal cancer...
  65. Sader H, Rhomberg P, Farrell D, Jones R. Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes. Antimicrob Agents Chemother. 2011;55:2390-4 pubmed publisher
    ..KPC)- and extended-spectrum ?-lactamase (ESBL)-producing strains of Pseudomonas aeruginosa and Bacteroides fragilis. CXA-201 was 2- to 32-fold more active than ceftazidime and piperacillin-tazobactam against ceftazidime-..
  66. Murphy E, Morgelin M, Cooney J, Frick I. Interaction of Bacteroides fragilis and Bacteroides thetaiotaomicron with the kallikrein-kinin system. Microbiology. 2011;157:2094-105 pubmed publisher
    ..In this study, two species of the Gram-negative anaerobic commensal organism Bacteroides, namely Bacteroides fragilis and Bacteroides thetaiotaomicron, were found to bind HK and fibrinogen, the major clotting protein, from ..
  67. Herren C, Rocha E, Smith C. Genetic analysis of an important oxidative stress locus in the anaerobe Bacteroides fragilis. Gene. 2003;316:167-75 pubmed
    The obligate anaerobe, Bacteroides fragilis, is a highly aerotolerant intestinal tract organism that has evolved a complex oxidative stress response (OSR)...
  68. Rocha E, Smith C. Transcriptional regulation of the Bacteroides fragilis ferritin gene (ftnA) by redox stress. Microbiology. 2004;150:2125-34 pubmed publisher
    ..that the iron-storage protein ferritin is a component of the redox-stress response in the obligate anaerobe Bacteroides fragilis. It is up-regulated at transcriptional level under aerobic conditions but constitutively expressed at low ..
  69. Nakano V, Avila Campos M. Virulence markers and antimicrobial susceptibility of bacteria of the Bacteroides fragilis group isolated from stool of children with diarrhea in São Paulo, Brazil. Mem Inst Oswaldo Cruz. 2004;99:307-12 pubmed
    b>Bacteroides fragilis has been isolated from several human and non-human monomicrobial and mixed infections. In this study, some virulence markers and the antimicrobial susceptibility of bacteria of the B...
  70. Nakano V, Padilla G, do Valle Marques M, Avila Campos M. Plasmid-related beta-lactamase production in Bacteroides fragilis strains. Res Microbiol. 2004;155:843-6 pubmed
    Twenty Bacteroides fragilis group species isolated from children with and without diarrhea were analyzed...
  71. Snydman D, Jacobus N, McDermott L. In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. Antimicrob Agents Chemother. 2008;52:4492-6 pubmed publisher
    Doripenem was evaluated against 527 recent clinical isolates, i.e., 404 Bacteroides fragilis isolates and 123 gram-positive anaerobe isolates. Against B...
  72. Coyne M, Fletcher C, Reinap B, Comstock L. UDP-glucuronic acid decarboxylases of Bacteroides fragilis and their prevalence in bacteria. J Bacteriol. 2011;193:5252-9 pubmed publisher
    ..In this report, we identify and confirm the activities of two Uxs-type UDP-GlcA decarboxylases of Bacteroides fragilis, designated BfUxs1 and BfUxs2. Bfuxs1 is located in a conserved region of the B...
  73. Wexler H. Pump it up: occurrence and regulation of multi-drug efflux pumps in Bacteroides fragilis. Anaerobe. 2012;18:200-8 pubmed publisher
    b>Bacteroides fragilis is a gram-negative anaerobic commensal that can be a virulent pathogen when it escapes its normal niche in the human gut...
  74. Shiryaev S, Aleshin A, Muranaka N, Kukreja M, Routenberg D, Remacle A, et al. Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island. FEBS J. 2014;281:2487-502 pubmed publisher
    b>Bacteroides fragilis causes the majority of anaerobic infections in humans. The presence of a pathogenicity island in the genome discriminates pathogenic and commensal B. fragilis strains...
  75. Cerdeño Tárraga A, Patrick S, Crossman L, Blakely G, Abratt V, Lennard N, et al. Extensive DNA inversions in the B. fragilis genome control variable gene expression. Science. 2005;307:1463-5 pubmed
    The obligately anaerobic bacterium Bacteroides fragilis, an opportunistic pathogen and inhabitant of the normal human colonic microbiota, exhibits considerable within-strain phase and antigenic variation of surface components...
  76. Ueda O, Wexler H, Hirai K, Shibata Y, Yoshimura F, Fujimura S. Sixteen homologs of the mex-type multidrug resistance efflux pump in Bacteroides fragilis. Antimicrob Agents Chemother. 2005;49:2807-15 pubmed
    ..resistance efflux pump operons of the resistance-nodulation-cell division (RND) family were found in the Bacteroides fragilis genome sequence by homology searches...
  77. Robertson K, Smith C, Gough A, Rocha E. Characterization of Bacteroides fragilis hemolysins and regulation and synergistic interactions of HlyA and HlyB. Infect Immun. 2006;74:2304-16 pubmed
    ..the presence of 10 hemolysin orthologs in the genome of the opportunistic human anaerobic pathogen Bacteroides fragilis, which is currently classified as a nonhemolytic bacterium...
  78. Kim J, Lee J, Yoon Y, Oh Y, Kang J, Kim Y, et al. Bacteroides fragilis enterotoxin induces cyclooxygenase-2 and fluid secretion in intestinal epithelial cells through NF-kappaB activation. Eur J Immunol. 2006;36:2446-56 pubmed
    b>Bacteroides fragilis produces an approximately 20-kDa heat-labile toxin (B. fragilis enterotoxin, BFT) which is known to be associated with diarrhea...
  79. Pumbwe L, Chang A, Smith R, Wexler H. BmeRABC5 is a multidrug efflux system that can confer metronidazole resistance in Bacteroides fragilis. Microb Drug Resist. 2007;13:96-101 pubmed
    ..pump gene bmeB5 was previously shown to be overexpressed in metronidazole-resistant laboratory mutants of Bacteroides fragilis. In the present study, we characterized the bmeABC5 genes and an upstream putative TetR-family regulator ..
  80. Lobo L, Smith C, Rocha E. Flavin mononucleotide (FMN)-based fluorescent protein (FbFP) as reporter for gene expression in the anaerobe Bacteroides fragilis. FEMS Microbiol Lett. 2011;317:67-74 pubmed publisher
    ..protein (FbFP) BS2 as a marker for gene expression in the opportunistic human anaerobic pathogen Bacteroides fragilis. Bacteroides fragilis 638R strain carrying osu?bs2 constructs showed inducible fluorescence following ..
  81. Schaumann R, Goldstein E, Forberg J, Rodloff A. Activity of moxifloxacin against Bacteroides fragilis and Escherichia coli in an in vitro pharmacokinetic/pharmacodynamic model employing pure and mixed cultures. J Med Microbiol. 2005;54:749-53 pubmed
    ..of this study was to determine the pharmacodynamic (PD) activity of moxifloxacin against four selected Bacteroides fragilis strains (three strains with low MICs and one strain with a high MIC) and two Escherichia coli strains (one ..
  82. Ang L, Brenwald N, Walker R, Andrews J, Fraise A. Carbapenem resistance in Bacteroides fragilis. J Antimicrob Chemother. 2007;59:1042-4 pubmed
  83. Wexler H. Bacteroides: the good, the bad, and the nitty-gritty. Clin Microbiol Rev. 2007;20:593-621 pubmed
    ..Clinically, Bacteroides species have exhibited increasing resistance to many antibiotics, including cefoxitin, clindamycin, metronidazole, carbapenems, and fluoroquinolones (e.g., gatifloxacin, levofloxacin, and moxifloxacin)...
  84. Sijbrandi R, Stork M, Luirink J, Otto B. Pbp, a cell-surface exposed plasminogen binding protein of Bacteroides fragilis. Microbes Infect. 2008;10:514-21 pubmed publisher
    ..coli and B. fragilis. Pbp-like proteins were also detected in some other Bacteroides subspecies. The role of this potential B. fragilis virulence factor in pathogenicity is discussed...
  85. Vieira J, Seabra S, Vallim D, Américo M, Fracallanza S, Vommaro R, et al. Bacteroides fragilis induce necrosis on mice peritoneal macrophages: In vitro and in vivo assays. Biochem Biophys Res Commun. 2009;387:627-32 pubmed publisher
    b>Bacteroides fragilis is an anaerobic bacteria component of human intestinal microbiota and agent of infections. In the host B. fragilis interacts with macrophages, which produces toxic radicals like NO...
  86. Thornton R, Kagawa T, O Toole P, Cooney J. The dissemination of C10 cysteine protease genes in Bacteroides fragilis by mobile genetic elements. BMC Microbiol. 2010;10:122 pubmed publisher
    ..The presence of homologues of cysteine protease genes in human commensal organisms has not been examined. Bacteroides fragilis is a member of the dominant Bacteroidetes phylum of the human intestinal microbiota, and is a significant ..
  87. Fernandez Canigia L, Litterio M, Legaria M, Castello L, Predari S, Di Martino A, et al. First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina. Antimicrob Agents Chemother. 2012;56:1309-14 pubmed publisher
    The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; ..
  88. Swidsinski A, Weber J, Loening Baucke V, Hale L, Lochs H. Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. J Clin Microbiol. 2005;43:3380-9 pubmed
    ..b>Bacteroides fragilis was responsible for >60% of the biofilm mass in patients with IBD but for only 30% of the biofilm mass ..
  89. Ulger Toprak N, Rajendram D, Yagci A, Gharbia S, Shah H, Gulluoglu B, et al. The distribution of the bft alleles among enterotoxigenic Bacteroides fragilis strains from stool specimens and extraintestinal sites. Anaerobe. 2006;12:71-4 pubmed
    Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in diarrhoeal illness in animals and humans. Recent data suggest that ETBF is associated with flares of inflammatory bowel disease...
  90. Spence C, Wells W, Smith C. Characterization of the primary starch utilization operon in the obligate anaerobe Bacteroides fragilis: Regulation by carbon source and oxygen. J Bacteriol. 2006;188:4663-72 pubmed
    The opportunistic pathogen Bacteroides fragilis is a commensal organism in the large intestine, where it utilizes both dietary and host-derived polysaccharides as a source of carbon and energy...
  91. Liu C, Huang Y, Liao C, Yen L, Lin H, Hsueh P. Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. Antimicrob Agents Chemother. 2008;52:3161-8 pubmed publisher
    ..used antianaerobic agents of five clinically frequently encountered anaerobes from 2000 to 2007 and to Bacteroides fragilis isolates causing nosocomial infections from 1990 to 2006...
  92. Steffens L, Nicholson S, Paul L, Nord C, Patrick S, Abratt V. Bacteroides fragilis RecA protein overexpression causes resistance to metronidazole. Res Microbiol. 2010;161:346-54 pubmed publisher
    b>Bacteroides fragilis is a human gut commensal and an opportunistic pathogen causing anaerobic abscesses and bacteraemias which are treated with metronidazole (Mtz), a DNA damaging agent...