ascorbate peroxidases


Summary: Peroxidases that utilize ASCORBIC ACID as an electron donor to reduce HYDROGEN PEROXIDE to WATER. The reaction results in the production of monodehydroascorbic acid and DEHYDROASCORBIC ACID.

Top Publications

  1. Muradoglu F, Gundogdu M, Ercisli S, Encu T, Balta F, Jaafar H, et al. Cadmium toxicity affects chlorophyll a and b content, antioxidant enzyme activities and mineral nutrient accumulation in strawberry. Biol Res. 2015;48:11 pubmed publisher
    ..Strawberry roots accumulated higher Cd than leaves. We found that MDA and antioxidant enzyme (CAT, SOD and APX) contents may have considered a good indicator in determining Cd tolerance in strawberry plant. ..
  2. Zafari S, Sharifi M, Mur L, Chashmi N. Favouring NO over H2O2 production will increase Pb tolerance in Prosopis farcta via altered primary metabolism. Ecotoxicol Environ Saf. 2017;142:293-302 pubmed publisher
    ..Our observations are consistent with conditions favouring NO production and reduced H2O2 can improve Pb tolerance via wide-ranging effects on a primary metabolic network. ..
  3. Esperanza M, Houde M, Seoane M, Cid A, Rioboo C. Does a short-term exposure to atrazine provoke cellular senescence in Chlamydomonas reinhardtii?. Aquat Toxicol. 2017;189:184-193 pubmed publisher
    ..Overall molecular and cellular results suggest that a short-term exposure to a sublethal concentration of atrazine may induce senescence features in microalgal cells which are the base of aquatic food webs. ..
  4. Lin Q, Liou Y. Fishing for key players in ER-mitochondrial contacts. J Biol Chem. 2017;292:16393-16394 pubmed publisher
    ..A new study makes use of the ascorbate peroxidase proximity-labeling proteomics approach to scrutinize the components of EMCs in live cells, leading to the identification of reticulon 1A as a novel promoter of EMCs. ..
  5. Wang J, Wu B, Yin H, Fan Z, Li X, Ni S, et al. Overexpression of CaAPX Induces Orchestrated Reactive Oxygen Scavenging and Enhances Cold and Heat Tolerances in Tobacco. Biomed Res Int. 2017;2017:4049534 pubmed publisher
    ..Overall, this study presents a comprehensive characterization of cellular response related to CaAPX expression and provides insights to breed crops with high temperature tolerances. ..
  6. Lobingier B, Hüttenhain R, Eichel K, Miller K, Ting A, von Zastrow M, et al. An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell. 2017;169:350-360.e12 pubmed publisher
    ..Validating its utility as a discovery pipeline, we establish that two of these proteins promote ubiquitin-linked receptor downregulation after prolonged activation. ..
  7. Ueno M, Nishiguchi T, Takeshita S, Yamaguchi K, Oda T. Effects of alginate oligomer on the expression of cell cycle- and stress-related genes in Chlamydomonas reinhardtii. Biosci Biotechnol Biochem. 2017;81:1254-1260 pubmed publisher
    ..These results suggest that AO exhibits beneficial effects on C. reinhardtii through influencing the expression of various genes not only at normal growth condition but also under CuSO4 stress. ..
  8. Ma Z, Davidson V. Ascorbate protects the diheme enzyme, MauG, against self-inflicted oxidative damage by an unusual antioxidant mechanism. Biochem J. 2017;474:2563-2572 pubmed publisher
    ..This could be a previously unrecognized mechanism by which ascorbate mitigates oxidative damage to heme-dependent enzymes and redox proteins in nature. ..
  9. Cho I, Adelmant G, Lim Y, Marto J, Cho G, Golden J. Ascorbate peroxidase proximity labeling coupled with biochemical fractionation identifies promoters of endoplasmic reticulum-mitochondrial contacts. J Biol Chem. 2017;292:16382-16392 pubmed publisher

More Information


  1. Cahyanurani A, Chiu K, Wu T. Glutathione biosynthesis plays an important role against 4-tert-octylphenol-induced oxidative stress in Ceratophyllum demersum. Chemosphere. 2017;183:565-573 pubmed publisher
    ..Thus, with OP-induced oxidative stress, C. demersum might actively regulate the antioxidant machinery, especially the biosynthesis and redox state of GSH. ..
  2. Chu Q, Rathore A, Diedrich J, Donaldson C, Yates J, Saghatelian A. Identification of Microprotein-Protein Interactions via APEX Tagging. Biochemistry. 2017;56:3299-3306 pubmed publisher
  3. Sen A, Alikamanoğlu S. Characterization of drought-tolerant sugar beet mutants induced with gamma radiation using biochemical analysis and isozyme variations. J Sci Food Agric. 2014;94:367-72 pubmed
    ..Furthermore, CAT and APX isozymes were detected at different intensities on native gels. In vitro mutagenesis is a useful technique for improving plant tolerance against environmental stresses. ..
  4. Paek J, Kalocsay M, Staus D, Wingler L, Pascolutti R, Paulo J, et al. Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling. Cell. 2017;169:338-349.e11 pubmed publisher
  5. Ding Y, Wang Y, Zheng X, Cheng W, Shi R, Feng R. Effects of foliar dressing of selenite and silicate alone or combined with different soil ameliorants on the accumulation of As and Cd and antioxidant system in Brassica campestris. Ecotoxicol Environ Saf. 2017;142:207-215 pubmed publisher
    ..campestris. ..
  6. Shackira A, Puthur J, Nabeesa Salim E. Acanthus ilicifolius L. a promising candidate for phytostabilization of zinc. Environ Monit Assess. 2017;189:282 pubmed publisher
    ..7 mg of Zn) and at the same time a poor translocator of Zn to the aerial parts of the plant, A. ilicifolius can be recommended as a potential candidate for the phytostabilization of Zn in the contaminated wetlands. ..
  7. Martell J, Deerinck T, Lam S, Ellisman M, Ting A. Electron microscopy using the genetically encoded APEX2 tag in cultured mammalian cells. Nat Protoc. 2017;12:1792-1816 pubmed publisher
    ..Notably, the only additional steps required relative to a standard EM sample preparation are cell transfection and a 2- to 45-min staining period with 3,3-diaminobenzidine (DAB) and hydrogen peroxide (H2O2). ..