arginase

Summary

Summary: A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1.

Top Publications

  1. Whyte C, Bishop E, Rückerl D, Gaspar Pereira S, Barker R, Allen J, et al. Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function. J Leukoc Biol. 2011;90:845-54 pubmed publisher
    ..in BMDM, we reveal that the enhanced SOCS1 is crucial for IL-4-induced M2 characteristics, including a high arginase I:iNOS activity ratio, suppression of T cell proliferation, attenuated responses to IFN-?/LPS, and curtailed ..
  2. Pernow J, Jung C. Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?. Cardiovasc Res. 2013;98:334-43 pubmed publisher
    ..A key factor regulating endothelial function is the bioavailability of nitric oxide (NO). Recently, the enzyme arginase has emerged as an important regulator of NO production by competing for l-arginine, which is a substrate for both ..
  3. Barron L, Smith A, El Kasmi K, Qualls J, Huang X, Cheever A, et al. Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS ONE. 2013;8:e61961 pubmed publisher
    Th2-driven lung inflammation increases Arginase 1 (Arg1) expression in alternatively-activated macrophages (AAMs)...
  4. Cloke T, Munder M, Taylor G, Muller I, Kropf P. Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection. PLoS ONE. 2012;7:e48939 pubmed publisher
    ..We have previously shown that arginase, an enzyme with potent immunosuppressive properties, is increased in HIV seropositive (HIV+) patients with low ..
  5. Ilies M, Di Costanzo L, Dowling D, Thorn K, Christianson D. Binding of ?,?-disubstituted amino acids to arginase suggests new avenues for inhibitor design. J Med Chem. 2011;54:5432-43 pubmed publisher
    b>Arginase is a binuclear manganese metalloenzyme that hydrolyzes L-arginine to form L-ornithine and urea, and aberrant arginase activity is implicated in various diseases such as erectile dysfunction, asthma, atherosclerosis, and cerebral ..
  6. Morris S, Gao T, Cooper T, Kepka Lenhart D, Awad A. Arginase-2 mediates diabetic renal injury. Diabetes. 2011;60:3015-22 pubmed publisher
    To determine 1) whether renal arginase activity or expression is increased in diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN).
  7. Elms S, Toque H, Rojas M, Xu Z, Caldwell R, Caldwell R. The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes. Diabetologia. 2013;56:654-62 pubmed publisher
    ..We hypothesise that activation of the arginase pathway could have a role in the vascular dysfunction of diabetic retinopathy...
  8. Vaisman B, Andrews K, Khong S, Wood K, Moore X, Fu Y, et al. Selective endothelial overexpression of arginase II induces endothelial dysfunction and hypertension and enhances atherosclerosis in mice. PLoS ONE. 2012;7:e39487 pubmed publisher
    ..b>Arginase in the vasculature can compete with eNOS for L-arginine and has been implicated in atherosclerosis...
  9. Zhao Z, Zhang J, Wei J, Li Z, Wang T, Yi S, et al. Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection. PLoS ONE. 2013;8:e63650 pubmed publisher
    ..Previous studies have demonstrated that inducible nitric oxide synthase (iNOS) and arginase-1 of rodent peritoneal macrophages are linked to the mechanism of resistance...

More Information

Publications88

  1. Shweash M, Adrienne McGachy H, Schroeder J, Neamatallah T, Bryant C, Millington O, et al. Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression. Mol Immunol. 2011;48:1800-8 pubmed publisher
    ..Promastigotes also increased macrophage arginase-1 expression and enhanced arginase activity, both of which were substantially reduced in TLR-4 but not TLR-2 ..
  2. da Silva M, Zampieri R, Muxel S, Beverley S, Floeter Winter L. Leishmania amazonensis arginase compartmentalization in the glycosome is important for parasite infectivity. PLoS ONE. 2012;7:e34022 pubmed publisher
    ..de novo polyamine synthesis is initiated by the cleavage of L-arginine to urea and L-ornithine by the action of arginase (ARG, E.C. 3.5.3.1). Previous studies in L. major and L...
  3. Jiang J, George S. TGF-?2 reduces nitric oxide synthase mRNA through a ROCK-dependent pathway in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;301:L361-7 pubmed publisher
    ..b>Arginase and NO synthase (NOS) utilize the same substrate (l-arginine) and contribute to the fibrotic and inflammatory ..
  4. Sharda D, Yu S, Ray M, Squadrito M, De Palma M, Wynn T, et al. Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase. J Immunol. 2011;187:2181-92 pubmed publisher
    ..These divergent phenotypes are characterized, in part, by the expression of inducible NO synthase and arginase I (Arg1) in M1 versus M2 activated macrophages, respectively...
  5. Kotsakis A, Harasymczuk M, Schilling B, Georgoulias V, Argiris A, Whiteside T. Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples. J Immunol Methods. 2012;381:14-22 pubmed publisher
    ..CFSE-based suppressor assays were used to test inhibitory functions of MDSC. Arginase I expression and reactive oxygen species (ROS) upregulation in MDSC subsets were evaluated by flow cytometry...
  6. Romero M, Iddings J, Platt D, Ali M, Cederbaum S, Stepp D, et al. Diabetes-induced vascular dysfunction involves arginase I. Am J Physiol Heart Circ Physiol. 2012;302:H159-66 pubmed publisher
    b>Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-arginine and by increasing cell proliferation and collagen formation, which promote vascular fibrosis/stiffening...
  7. Narayanan S, Suwanpradid J, Saul A, Xu Z, Still A, Caldwell R, et al. Arginase 2 deletion reduces neuro-glial injury and improves retinal function in a model of retinopathy of prematurity. PLoS ONE. 2011;6:e22460 pubmed publisher
    ..This study was undertaken to determine the role of the mitochondrial arginine/ornithine regulating enzyme arginase 2 (A2) in retinal neuro-glial cell injury in the mouse model of ROP.
  8. McKnight R, Nassar A, Cohen C, Siddiqui M. Arginase-1: a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology. Cancer Cytopathol. 2012;120:223-9 pubmed publisher
    b>Arginase-I is a key urea cycle metalloenzyme that has been used as an immunohistochemistry (IHC) marker for hepatocellular carcinoma (HCC)...
  9. Badaut J, Copin J, Fukuda A, Gasche Y, Schaller K, da Silva R. Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit. J Neuroinflammation. 2012;9:132 pubmed publisher
    ..Increase in arginase activity was shown to participate in vascular dysfunction in the peripheral arteries of atherosclerotic mice by ..
  10. Amrouni D, Meiller A, Gautier Sauvigné S, Piraud M, Bouteille B, Vincendeau P, et al. Cerebral changes occurring in arginase and dimethylarginine dimethylaminohydrolase (DDAH) in a rat model of sleeping sickness. PLoS ONE. 2011;6:e16891 pubmed publisher
    ..The present approach analyses the brain impairments occurring in the regulations exerted by arginase and N(G), N(G)-dimethylarginine dimethylaminohydrolase (DDAH) on NO Synthases (NOS)...
  11. Toque H, Romero M, Tostes R, Shatanawi A, Chandra S, Carneiro Z, et al. p38 Mitogen-activated protein kinase (MAPK) increases arginase activity and contributes to endothelial dysfunction in corpora cavernosa from angiotensin-II-treated mice. J Sex Med. 2010;7:3857-67 pubmed publisher
    Angiotensin II (AngII) activates p38 mitogen-activated protein kinase (MAPK) and elevates arginase activity in endothelial cells...
  12. Shi H, Ye T, Chen F, Cheng Z, Wang Y, Yang P, et al. Manipulation of arginase expression modulates abiotic stress tolerance in Arabidopsis: effect on arginine metabolism and ROS accumulation. J Exp Bot. 2013;64:1367-79 pubmed publisher
    Arginine is an important medium for the transport and storage of nitrogen, and arginase (also known as arginine amidohydrolase, ARGAH) is responsible for catalyse of arginine into ornithine and urea in plants...
  13. Yepuri G, Velagapudi S, Xiong Y, Rajapakse A, Montani J, Ming X, et al. Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging. Aging Cell. 2012;11:1005-16 pubmed publisher
    Augmented activities of both arginase and S6K1 are involved in endothelial dysfunction in aging...
  14. Heuvers M, Muskens F, Bezemer K, Lambers M, Dingemans A, Groen H, et al. Arginase-1 mRNA expression correlates with myeloid-derived suppressor cell levels in peripheral blood of NSCLC patients. Lung Cancer. 2013;81:468-74 pubmed publisher
    ..05). We found that PMN-MDSC were able to suppress T-cell proliferation in vitro. qRT-PCR showed that arginase-1 (Arg-1) mRNA is mainly expressed by MDSC and that the level of Arg-1 in PBMC correlates with the frequency of ..
  15. Csóka B, Selmeczy Z, Koscsó B, Németh Z, Pacher P, Murray P, et al. Adenosine promotes alternative macrophage activation via A2A and A2B receptors. FASEB J. 2012;26:376-86 pubmed publisher
    ..treatment of IL-4- or IL-13-activated macrophages augments the expression of alternative macrophage markers arginase-1, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), and macrophage galactose-type C-type lectin-1...
  16. Timek D, Shi J, Liu H, Lin F. Arginase-1, HepPar-1, and Glypican-3 are the most effective panel of markers in distinguishing hepatocellular carcinoma from metastatic tumor on fine-needle aspiration specimens. Am J Clin Pathol. 2012;138:203-10 pubmed publisher
    Distinction of liver metastases from hepatocellular carcinoma (HCC) may present a diagnostic challenge. Arginase-1 (Arg-1) is a marker for HCC recently described in some literature...
  17. Fitzpatrick J, Fuentes J, Chalmers I, Wynn T, Modolell M, Hoffmann K, et al. Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. Int J Parasitol. 2009;39:267-79 pubmed publisher
    ..for the first time that several developmental stages of the human parasite Schistosoma mansoni express arginase, which is responsible for the hydrolysis of l-arginine to l-ornithine and urea...
  18. Shin W, Berkowitz D, Ryoo S. Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice. Exp Mol Med. 2012;44:594-602 pubmed publisher
    ..There is accumulating evidence that arginase upregulation is associated with impaired endothelial function...
  19. Sheldon K, Shandilya H, Kepka Lenhart D, Poljakovic M, Ghosh A, Morris S. Shaping the murine macrophage phenotype: IL-4 and cyclic AMP synergistically activate the arginase I promoter. J Immunol. 2013;191:2290-8 pubmed publisher
    b>Arginase I is a marker of murine M2 macrophages and is highly expressed in many inflammatory diseases...
  20. Sin Y, Ballantyne L, Mukherjee K, St Amand T, Kyriakopoulou L, Schulze A, et al. Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism. PLoS ONE. 2013;8:e80001 pubmed publisher
    b>Arginase deficiency is a rare autosomal recessive disorder resulting from a loss of the liver arginase isoform, arginase 1 (ARG1), which is the final step in the urea cycle for detoxifying ammonia...
  21. Chen B, Calvert A, Meng X, Nelin L. Pharmacologic agents elevating cAMP prevent arginase II expression and proliferation of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 2012;47:218-26 pubmed publisher
    b>Arginase II has been shown to be involved in the hypoxia-induced proliferation of human pulmonary artery smooth muscle cells (hPASMCs). The signal transduction pathways responsible for the induction of arginase II are poorly understood...
  22. Cao J, Shi F. Dynamics of arginase gene evolution in metazoans. J Biomol Struct Dyn. 2012;30:407-18 pubmed publisher
    In the present study, a comprehensive analysis of the arginase gene family in metazoans was performed. A total of 126 arginase genes have been identified in 44 species...
  23. Stoermer K, Burrack A, Oko L, Montgomery S, Borst L, Gill R, et al. Genetic ablation of arginase 1 in macrophages and neutrophils enhances clearance of an arthritogenic alphavirus. J Immunol. 2012;189:4047-59 pubmed publisher
    ..macrophages present in these lesions, have a unique gene-expression pattern characterized by high expression of arginase 1 and Ym1/Chi3l3 in the absence of FIZZ1/Relm? that is consistent with an M2-like activation phenotype...
  24. da Silva E, Maquiaveli C, Magalhães P. The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase. Exp Parasitol. 2012;130:183-8 pubmed publisher
    ..b>Arginase, which is a metallohydrolase, is the first enzyme involved in polyamine biosynthesis and converts arginine into ..
  25. Wang X, Chen Y, Qin W, Zhang W, Wei S, Wang J, et al. Arginase I attenuates inflammatory cytokine secretion induced by lipopolysaccharide in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2011;31:1853-60 pubmed publisher
    Inflammation plays an important role in atherosclerosis. Arginase I (Arg I) promotes the proliferation of vascular smooth muscle cells; however, the effect of Arg I on inflammation remains unknown...
  26. Fujiwara M, Kwok S, Yano H, Pai R. Arginase-1 is a more sensitive marker of hepatic differentiation than HepPar-1 and glypican-3 in fine-needle aspiration biopsies. Cancer Cytopathol. 2012;120:230-7 pubmed publisher
    ..b>Arginase-1 was recently described as a marker of hepatic differentiation in surgical resection specimens...
  27. Srivastava S, Ratha B. Unusual hepatic mitochondrial arginase in an Indian air-breathing teleost, Heteropneustes fossilis: purification and characterization. Comp Biochem Physiol B Biochem Mol Biol. 2013;164:133-41 pubmed publisher
    A functional urea cycle with both cytosolic (ARG I) and mitochondrial (ARG II) arginase activity is present in the liver of an ureogenic air-breathing teleost, Heteropneustes fossilis...
  28. Butcher B, Fox B, Rommereim L, Kim S, Maurer K, Yarovinsky F, et al. Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control. PLoS Pathog. 2011;7:e1002236 pubmed publisher
    ..Furthermore, ROP16 triggered synthesis of host cell arginase-1 in a STAT6-dependent manner...
  29. Narita Y, Kitamura H, Wakita D, Sumida K, Masuko K, Terada S, et al. The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice. J Immunol. 2013;190:812-20 pubmed publisher
    ..cachectic factors, suppressed CD4(+) T cell-mediated immunity through downregulation of MHC class II by enhanced arginase activity of dendritic cells (DC) in tumor-bearing mice...
  30. Ino Y, Yamazaki Itoh R, Oguro S, Shimada K, Kosuge T, Zavada J, et al. Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer. PLoS ONE. 2013;8:e55146 pubmed publisher
    ..Arginine levels are regulated by the arginine-catabolizing enzyme, arginase (ARG)...
  31. Manjolin L, dos Reis M, Maquiaveli C, Santos Filho O, da Silva E. Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection. Food Chem. 2013;141:2253-62 pubmed publisher
    ..In this work, the structural aspects of 13 flavonoids were analyzed for their inhibition of the arginase enzyme from Leishmania (Leishmania) amazonensis...
  32. Gonon A, Jung C, Katz A, Westerblad H, Shemyakin A, Sjöquist P, et al. Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production. PLoS ONE. 2012;7:e42038 pubmed publisher
    ..The aim of the study was to determine myocardial arginase expression and activity in ischemic-reperfusion myocardium and whether local inhibition of arginase within the ..
  33. Hsueh E, Knebel S, Lo W, Leung Y, Cheng P, Hsueh C. Deprivation of arginine by recombinant human arginase in prostate cancer cells. J Hematol Oncol. 2012;5:17 pubmed publisher
    Recombinant human arginase (rhArg) has been developed for arginine deprivation therapy in cancer, and is currently under clinical investigation...
  34. Garrido V, Dulgerian L, Stempin C, Cerban F. The increase in mannose receptor recycling favors arginase induction and Trypanosoma cruzi survival in macrophages. Int J Biol Sci. 2011;7:1257-72 pubmed
    ..In this work, we have studied in Mo the role of MR in arginase induction and in T. cruzi survival using different MR ligands. We have showed that pre-incubation of T...
  35. Bando J, Nussbaum J, Liang H, Locksley R. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J Leukoc Biol. 2013;94:877-84 pubmed publisher
    ..brasiliensis infection. Thus, ILC2s are a novel source of Arg1 in resting tissue and during allergic inflammation. ..
  36. Sandalova E, Laccabue D, Boni C, Watanabe T, Tan A, Zong H, et al. Increased levels of arginase in patients with acute hepatitis B suppress antiviral T cells. Gastroenterology. 2012;143:78-87.e3 pubmed publisher
    ..of different modulatory mechanisms, such as inhibitory molecules, suppressive cytokines (interleukin-10), and arginase, on the activities of CD8(+) T cells...
  37. Yang J, Gonon A, Sjöquist P, Lundberg J, Pernow J. Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity. Proc Natl Acad Sci U S A. 2013;110:15049-54 pubmed publisher
    ..The aim of this study was to test the hypothesis that arginase reciprocally controls NO formation in RBCs by competition with eNOS for their common substrate arginine and that ..
  38. Ahn M, Lee C, Jung K, Kim H, Moon C, Sim K, et al. Immunohistochemical study of arginase-1 in the spinal cords of rats with clip compression injury. Brain Res. 2012;1445:11-9 pubmed publisher
    ..The level of arginase-1 expression in rat spinal cords with clip compression injury was determined by Western blot analysis and ..
  39. Pera T, Zuidhof A, Smit M, Menzen M, Klein T, Flik G, et al. Arginase inhibition prevents inflammation and remodeling in a guinea pig model of chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2014;349:229-38 pubmed publisher
    ..Recent studies in animal models have indicated that increased arginase activity contributes to features of asthma, including allergen-induced airway eosinophilia and mucus ..
  40. Radwan N, Ahmed N. The diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1. Diagn Pathol. 2012;7:149 pubmed publisher
    ..b>Arginase-1 is a marker for HCC recently described in some literature...
  41. McLarren K, Cole A, Weisser S, Voglmaier N, Conlin V, Jacobson K, et al. SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis. Am J Pathol. 2011;179:180-8 pubmed publisher
    ..we describe a spontaneous mouse model of intestinal inflammation with fibrosis and the profibrotic role of arginase I...
  42. Chandra S, Romero M, Shatanawi A, Alkilany A, Caldwell R, Caldwell R. Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway. Br J Pharmacol. 2012;165:506-19 pubmed publisher
    ..During diabetes, aging and hypertension, elevated levels of arginase can compete with NOS for available l-arginine, reducing NO and increasing superoxide (O(2) (...
  43. Pourcet B, Feig J, Vengrenyuk Y, Hobbs A, Kepka Lenhart D, Garabedian M, et al. LXR? regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8. Circ Res. 2011;109:492-501 pubmed publisher
    ..In addition, LXR? levels are high in regressive plaques. Macrophage arginase 1 (Arg1) expression is inversely correlated with atherosclerosis progression and is markedly decreased in foam ..
  44. Quitter F, Figulla H, Ferrari M, Pernow J, Jung C. Increased arginase levels in heart failure represent a therapeutic target to rescue microvascular perfusion. Clin Hemorheol Microcirc. 2013;54:75-85 pubmed publisher
    ..A mechanism possibly contributing to low NO bioavailability is the upregulation of arginase. Therefore, we investigated circulating arginase levels in patients with HF and its consequences for ..
  45. Castro I, Oliveira B, Slowikowski J, Coutinho B, Siqueira F, Costa L, et al. Arginine decreases Cryptosporidium parvum infection in undernourished suckling mice involving nitric oxide synthase and arginase. Nutrition. 2012;28:678-85 pubmed publisher
    ..L-NAME abrogated these arginine-induced improvements. The infected control mice showed an intense arginase expression, which was even greater with L-NAME...
  46. Yau T, Cheng P, Chan P, Chan W, Chen L, Yuen J, et al. A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma. Invest New Drugs. 2013;31:99-107 pubmed publisher
    ..PK)/ pharmacodynamics (PD) parameters, and potential anti-tumor activity of pegylated recombinant human arginase 1 (peg-rhArg1) in advanced HCC patients...
  47. Choi S, Park C, Ahn M, Lee J, Shin T. Immunohistochemical study of arginase 1 and 2 in various tissues of rats. Acta Histochem. 2012;114:487-94 pubmed publisher
    b>Arginase 1 and arginase 2 catalyze the hydrolysis of arginine to ornithine and urea. The localization of these enzymes was studied in various tissues in Sprague-Dawley rats by immunohistochemistry and Western blotting...
  48. Kavalukas S, Uzgare A, Bivalacqua T, Barbul A. Arginase inhibition promotes wound healing in mice. Surgery. 2012;151:287-95 pubmed publisher
    b>Arginase plays important regulatory roles in polyamine, ornithine, and nitric oxide syntheses. However, its role in the healing process has not been delineated...
  49. Bron L, Jandus C, Andrejevic Blant S, Speiser D, Monnier P, Romero P, et al. Prognostic value of arginase-II expression and regulatory T-cell infiltration in head and neck squamous cell carcinoma. Int J Cancer. 2013;132:E85-93 pubmed publisher
    ..Furthermore, arginase-II (ARG2) was expressed by 60%, inducible nitric oxide synthetase by 9%, cyclooxygenase-2 by 43%, and B-cell ..
  50. Eleftheriadis T, Yiannaki E, Antoniadi G, Liakopoulos V, Pissas G, Galaktidou G, et al. Plasma indoleamine 2,3-dioxygenase and arginase type I may contribute to decreased blood T-cell count in hemodialysis patients. Ren Fail. 2012;34:1118-22 pubmed publisher
    ..Indoleamine 2,3-dioxygenase (IDO) and arginase type I (ARG) catabolize tryptophane and arginine, respectively, and exert proapoptotic and antiproliferative ..
  51. Brauc S, De Vooght E, Claeys M, Geuns J, Hofte M, Angenon G. Overexpression of arginase in Arabidopsis thaliana influences defence responses against Botrytis cinerea. Plant Biol (Stuttg). 2012;14 Suppl 1:39-45 pubmed publisher
    Arabidopsis possesses two arginase-encoding genes, ARGAH1 and ARGAH2, catalysing the catabolism of arginine into ornithine and urea. Arginine and ornithine are both precursors for polyamine biosynthetic pathways...
  52. Kasten J, Hu C, Bhargava R, Park H, Tai D, Byrne J, et al. Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse. Mol Genet Metab. 2013;110:222-30 pubmed publisher
    Human arginase deficiency is characterized by hyperargininemia and infrequent episodes of hyperammonemia, which lead to neurological impairment with spasticity, loss of ambulation, seizures, and severe mental and growth retardation; ..
  53. Michell D, Andrews K, Chin Dusting J. Endothelial dysfunction in hypertension: the role of arginase. Front Biosci (Schol Ed). 2011;3:946-60 pubmed
    ..pathways such as ROS (reactive oxygen species) production and also recent reports suggest that the enzyme arginase, associated with the L-arginine-urea cycle, may be an important factor that is increased in hypertension...
  54. Li Z, Zhao Z, Zhu X, Ren Q, Nie F, Gao J, et al. Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection. PLoS ONE. 2012;7:e35834 pubmed publisher
    ..we report that high expression levels and activity of inducible nitric oxide synthase (iNOS) and low levels of arginase-1 (Arg 1) activity in the peritoneal macrophages of rats are responsible for their resistance against T...
  55. Lucas R, Yang G, Gorshkov B, Zemskov E, Sridhar S, Umapathy N, et al. Protein kinase C-? and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Am J Respir Cell Mol Biol. 2012;47:445-53 pubmed publisher
    ..At later time points, PLY treatment increases the expression and activity of arginase in HL-MVECs...
  56. Bekpinar S, Gurdol F, Unlucerci Y, Develi S, Yilmaz A. Serum levels of arginase I are associated with left ventricular function after myocardial infarction. Clin Biochem. 2011;44:1090-1093 pubmed publisher
    Upregulation of arginase redirects the arginine metabolism from nitric oxide (NO) synthesis to the formation of polyamine and proline, thus causing cardiac dysfunction...
  57. Balaña Fouce R, Calvo Álvarez E, Alvarez Velilla R, Prada C, Pérez Pertejo Y, Reguera R. Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis. Mol Biochem Parasitol. 2012;181:85-93 pubmed publisher
    ..L-Arginine is enzymatically hydrolyzed by arginase producing L-ornithine and urea. In Leishmania spp...
  58. Mou Z, Muleme H, Liu D, Jia P, Okwor I, Kuriakose S, et al. Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion. J Immunol. 2013;190:3380-9 pubmed publisher
    The breakdown of L-arginine to ornithine and urea by host arginase supports Leishmania proliferation in macrophages. Studies using arginase-null mutants show that Leishmania-derived arginase plays an important role in disease pathogenesis...
  59. Agrawal V, Woo J, Mauldin J, Jo C, Stone E, Georgiou G, et al. Cytotoxicity of human recombinant arginase I (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells. Anticancer Drugs. 2012;23:51-64 pubmed publisher
    Human recombinant arginase I cobalt [HuArgI (Co)] coupled with polyethylene glycol 5000 [HuArgI (Co)-PEG5000] has shown potent in-vitro depletion of arginine from tissue culture medium...
  60. Osorio E, Zhao W, Espitia C, Saldarriaga O, Hawel L, Byus C, et al. Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression. PLoS Pathog. 2012;8:e1002417 pubmed publisher
    ..001) and increased polyamine synthesis (p<0.05). Increased arginase activity was also evident in macrophages isolated from the spleens of infected hamsters (p<0...
  61. Ali N, Jafri A, Sopi R, Prakash Y, Martin R, Zaidi S. Role of arginase in impairing relaxation of lung parenchyma of hyperoxia-exposed neonatal rats. Neonatology. 2012;101:106-15 pubmed publisher
    ..We have previously demonstrated that neonatal exposure of rat pups to ?95% O2 impairs airway relaxation due to disruption of nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling...
  62. Lee E, Hu C, Bhargava R, Rozengurt N, Stout D, Grody W, et al. Long-term survival of the juvenile lethal arginase-deficient mouse with AAV gene therapy. Mol Ther. 2012;20:1844-51 pubmed publisher
    b>Arginase deficiency is characterized by hyperargininemia and infrequent episodes of hyperammonemia. Human patients suffer from neurological impairment with spasticity, loss of ambulation, seizures, and severe mental and growth retardation...
  63. Pessanha A, Martins R, Mattos Guaraldi A, Vianna A, Moreira L. Arginase-1 expression in granulomas of tuberculosis patients. FEMS Immunol Med Microbiol. 2012;66:265-8 pubmed publisher
    ..with the ability of mouse macrophages to produce antibactericidal nitric oxide, by inducing the expression of arginase 1 (Arg1). It remains unclear whether this pathway has a role in humans infected with Mtb...
  64. Fu H, Khan A, Coe D, Zaher S, Chai J, Kropf P, et al. Arginine depletion as a mechanism for the immune privilege of corneal allografts. Eur J Immunol. 2011;41:2997-3005 pubmed publisher
    The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine ..
  65. da Silva M, Floeter Winter L. Arginase in Leishmania. Subcell Biochem. 2014;74:103-17 pubmed publisher
    ..One of these enzymes is arginase (L-arginine amidinohydrolase, E.C. 3.5.3...
  66. Prieto C, Krause B, Quezada C, San Martin R, Sobrevia L, Casanello P. Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium. Placenta. 2011;32:932-40 pubmed publisher
    ..It has been reported that arginase-2 expression, an alternative pathway for l-arginine metabolism, is increased in adult endothelial cells exposed ..
  67. Kim O, Lee S, Chung J, Do H, Moon J, Shin M. Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity. Nutrition. 2012;28:635-9 pubmed publisher
    ..The mRNA levels of genes (arginase I [ARG1], very low-density lipoprotein receptor [VLDLR], adiponectin receptor-1 [ADIPOR1], ADIPOR2, and nitric ..
  68. Xiong Y, Yu Y, Montani J, Yang Z, Ming X. Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability. J Am Heart Assoc. 2013;2:e000096 pubmed publisher
    Vascular smooth muscle cell (VSMC) senescence and apoptosis are involved in atherosclerotic plaque vulnerability. Arginase-II (Arg-II) has been shown to promote vascular dysfunction and plaque vulnerability phenotypes in mice through ..
  69. Narayanan S, Rojas M, Suwanpradid J, Toque H, Caldwell R, Caldwell R. Arginase in retinopathy. Prog Retin Eye Res. 2013;36:260-80 pubmed publisher
    ..This review examines the potential role of the ureahydrolase enzyme arginase as a therapeutic target for the treatment of ischemic retinopathy...
  70. Toque H, Nunes K, Yao L, Liao J, Webb R, Caldwell R, et al. Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation. J Sex Med. 2013;10:1502-15 pubmed publisher
    ..Earlier studies have demonstrated involvement of ROCK pathway in the activation of arginase in endothelial cells. However, signaling pathways activated by ROCK in the penis remain unclear...
  71. Shi H, Chan Z. In vivo role of Arabidopsis arginase in arginine metabolism and abiotic stress response. Plant Signal Behav. 2013;8:e24138 pubmed publisher
    ..Function of arginase, another important enzyme involved in arginine metabolism, in abiotic stress remains largely unknown...
  72. Nunes K, Toque H, Caldwell R, Caldwell R, Webb R. Extracellular signal-regulated kinase (ERK) inhibition decreases arginase activity and improves corpora cavernosal relaxation in streptozotocin (STZ)-induced diabetic mice. J Sex Med. 2011;8:3335-44 pubmed publisher
    Increased arginase activity (AA) has been implicated in hypertension and diabetes-induced endothelial dysfunction by reducing L-arginine availability and nitric oxide production...
  73. Abebe T, Hailu A, Woldeyes M, Mekonen W, Bilcha K, Cloke T, et al. Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia. PLoS Negl Trop Dis. 2012;6:e1684 pubmed publisher
    ..We have recently shown in an experimental model of cutaneous leishmaniasis that arginase-induced L-arginine metabolism suppresses antigen-specific T cell responses at the site of pathology, but not in ..
  74. Olivon V, Fraga Silva R, Segers D, Demougeot C, de Oliveira A, Savergnini S, et al. Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE-/- mice. Atherosclerosis. 2013;227:236-43 pubmed publisher
    Wall shear stress differentially regulates the arginase pathway in carotid arteries perfused ex vivo. Specific patterns of wall shear stress can locally determine atherosclerotic plaque size and composition in vivo...
  75. Pourcet B, Pineda Torra I. Transcriptional regulation of macrophage arginase 1 expression and its role in atherosclerosis. Trends Cardiovasc Med. 2013;23:143-52 pubmed publisher
    ..A number of macrophage subsets have been identified in atherosclerotic plaques. Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a ..
  76. Shemyakin A, Kövamees O, Rafnsson A, Bohm F, Svenarud P, Settergren M, et al. Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus. Circulation. 2012;126:2943-50 pubmed publisher
    ..Increased expression and activity of arginase, metabolizing the nitric oxide substrate l-arginine, may result in reduced production of nitric oxide and thereby ..
  77. Cho W, Lee C, Kang M, Huang Y, Giordano F, Lee P, et al. IL-13 receptor ?2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013;304:L112-24 pubmed publisher
    ..IL-13 Tg mice spontaneously developed PH phenotype by the age of 2 mo with increased expression and activity of arginase 2 (Arg2)...
  78. Yao L, Chandra S, Toque H, Bhatta A, Rojas M, Caldwell R, et al. Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout. Cardiovasc Res. 2013;97:509-19 pubmed publisher
    ..role of the Rho kinase (ROCK) isoforms in diabetes-induced vascular endothelial dysfunction and enhancement of arginase activity and expression...
  79. Bailey W, Holder D, Patel H, Devlin P, Gonzalez R, Hamilton V, et al. A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase. Toxicol Sci. 2012;130:229-44 pubmed publisher
    ..candidates have been evaluated in 34 acute toxicity rat studies: (1) alpha-glutathione S-transferase (GSTA), (2) arginase 1 (ARG1), and (3) 4-hydroxyphenylpyruvate dioxygenase (HPD)...