macaca mulatta

Summary

Alias: rhesus macaque
Summary: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.

Webpages

  1. map viewer
    ncbi.nih.gov/mapview/map_search.cgi?txid=9606
  2. kegg pathway: glycolysis / gluconeogenesis - reference pathway
    www.genome.ad.jp/kegg/pathway/map/map00010.html
  3. fasta tool for sequence similarity searching genome databases | ebi
    www.ebi.ac.uk/Tools/fasta33/genomes.html
  4. kegg pathway: glyoxylate and dicarboxylate metabolism - photobacterium profundum
    www.genome.ad.jp/dbget-bin/show_pathway?ppr00630+PBPRA2275
  5. kegg pathway: ribosome - theileria parva
    www.genome.jp/dbget-bin/show_pathway?tpv03010+TP04_0836
  6. orandle.html
    www.vetmed.lsu.edu/pbs/orandle.htm
  7. recombinant l monocytogenes as an siv vaccine
    www.med.unc.edu/wrkunits/1dean/research/Kaplan180.html
  8. crab-eating macaque - invasion biology introduced species summary project - columbia university
    www.columbia.edu/itc/cerc/danoff-burg/invasion_bio/inv_spp_s ...
  9. clinical research group / project ii
    www.med.uni-marburg.de/stpg/ukm/lb/pneumologie/klin_fg/tv2/t ...
  10. tnprc: types of nonhuman primates
    www.tnprc.tulane.edu/public_types.html

Research Grants

  1. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2008
  2. Transplant Tolerance in Non-Human Primates
    Christian P Larsen; Fiscal Year: 2008
  3. SEQUENCE AND POLYMORPHISM OF RHESUS MACAQUE MHC
    Daniel E Geraghty; Fiscal Year: 2006
  4. Prevention of AIDS
    Barbara Felber; Fiscal Year: 2006
  5. Bone marrow monocyte output and virus import into the CNS in acute SIV infection
    Ursula Esser; Fiscal Year: 2008
  6. A Rhesus Macaque Model of SIV-Malaria Co-Infection
    Kristina Abel; Fiscal Year: 2008
  7. Cellular Immune Responses Induced by SIVdelta-vif plus IL-15 DNA Vaccine
    ELLEN ELIZABETH SPARGER; Fiscal Year: 2008
  8. Design of Antiviral Drugs Effective Against the HIV-1 Vi
    Ettore Appella; Fiscal Year: 2006
  9. GM-CSF-Adjuvanted Clade C DNA/MVA and MVA/MVA Vaccines
    Harriet L Robinson; Fiscal Year: 2008
  10. HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTION
    Changyi Chen; Fiscal Year: 2004

Publications

  1. Redundancy reduction and sustained firing with stochastic depressing synapses
    Mark S Goldman
    Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 22:584-91
  2. Neuronal activity in primate dorsolateral and orbital prefrontal cortex during performance of a reward preference task
    Jonathan D Wallis
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, E25 236, 45 Carleton Street, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Eur J Neurosci 18:2069-81
  3. Prefrontal cortex activity related to abstract response strategies
    Aldo Genovesio
    Neuron 47:307-20
  4. Contributions of prefrontal cue-, delay-, and response-period activity to the decision process of saccade direction in a free-choice ODR task
    Kei Watanabe
    Department of Cognitive and Behavioral Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    Neural Netw 19:1203-22
  5. Impact of experience on the representation of object-centered space in the macaque supplementary eye field
    David E Moorman
    Center for the Neural Basis of Cognition, Mellon Institute, Room 115, 4400 Fifth Avenue, Pittsburgh, PA 15213 2683, USA
    J Neurophysiol 97:2159-73
  6. Action and outcome encoding in the primate caudate nucleus
    Brian Lau
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 27:14502-14
  7. Deficits in saccade target selection after inactivation of superior colliculus
    Robert M McPeek
    The Smith Kettlewell Eye Research Institute, 2318 Fillmore Street, San Francisco, California 94115, USA
    Nat Neurosci 7:757-63
  8. Neural activity in monkey prefrontal cortex is modulated by task context and behavioral instruction during delayed-match-to-sample and conditional prosaccade-antisaccade tasks
    Kevin Johnston
    Department of Physiology and Pharmocology, University of Western Ontario, London, ON, Canada
    J Cogn Neurosci 18:749-65
  9. Rule-dependent activity for prosaccades and antisaccades in the primate prefrontal cortex
    Stefan Everling
    University of Western Ontario, London, Canada
    J Cogn Neurosci 17:1483-96
  10. Dynamic circuitry for updating spatial representations. III. From neurons to behavior
    Rebecca A Berman
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsbirgh, Pittsburgh, PA, USA
    J Neurophysiol 98:105-21

Scientific Experts

Detail Information

Webpages77 found, 30 most recent shown here

  1. map viewer
    ncbi.nih.gov/mapview/map_search.cgi?txid=9606
  2. kegg pathway: glycolysis / gluconeogenesis - reference pathway
    www.genome.ad.jp/kegg/pathway/map/map00010.html
  3. fasta tool for sequence similarity searching genome databases | ebi
    www.ebi.ac.uk/Tools/fasta33/genomes.html
  4. kegg pathway: glyoxylate and dicarboxylate metabolism - photobacterium profundum
    www.genome.ad.jp/dbget-bin/show_pathway?ppr00630+PBPRA2275
  5. kegg pathway: ribosome - theileria parva
    www.genome.jp/dbget-bin/show_pathway?tpv03010+TP04_0836
  6. orandle.html
    www.vetmed.lsu.edu/pbs/orandle.htm
  7. recombinant l monocytogenes as an siv vaccine
    www.med.unc.edu/wrkunits/1dean/research/Kaplan180.html
  8. crab-eating macaque - invasion biology introduced species summary project - columbia university
    www.columbia.edu/itc/cerc/danoff-burg/invasion_bio/inv_spp_s ...
  9. clinical research group / project ii
    www.med.uni-marburg.de/stpg/ukm/lb/pneumologie/klin_fg/tv2/t ...
  10. tnprc: types of nonhuman primates
    www.tnprc.tulane.edu/public_types.html
  11. cv - allison cleveland
    www.eva.mpg.de/evolution/staff/cleveland/cv.htm
  12. no title
    www.rpb.ioz.ac.cn/html/wangyanling.php
  13. rheumatology at the ucl institute of child health
    www.ich.ucl.ac.uk/ich/academicunits/Rheumatology/RecentPubli ...
  14. rheumatology at great ormond street hospital
    www.ich.ucl.ac.uk/gosh/clinicalservices/Rheumatology/RecentP ...
  15. university of pittsburgh :: mvm program
    www.gradbiomed.pitt.edu/mvm/faculty.asp?ID=85
  16. music 838: seminar in music perception
    dactyl.som.ohio-state.edu/Music838/music838.bibliography.htm ...
  17. bio staffs
    www.biology.sc.chula.ac.th/directories/staffs/aj/physio/such ...
  18. medline publication: neural coding of gustatory information in the thalamus of macaca mulatta
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/2918337
  19. blast basic local alignment search tools for searching protein or nucleotide databases | ebi
    www.ebi.ac.uk/Tools/blast/
  20. vcl : publications
    www.vcl.salk.edu/Publications/
  21. university of pittsburgh gsph idm faculty- albert d. donnenberg, phd
    www.idm.pitt.edu/faculty/donnenberg.html
  22. apolipoprotein superfamily domain assignments domain assignments in rickettsia rickettsii iowa
    supfam.mrc-lmb.cam.ac.uk/SUPERFAMILY/cgi-bin/genome.cgi?sf=4 ...
  23. mmv] « enantioselective 8-aminoquinolines
    www.mmv.org/article.php3?id_article=102
  24. tropomyosin superfamily domain assignments domain assignments in legionella pneumophila paris
    supfam.cs.bris.ac.uk/SUPERFAMILY/cgi-bin/genome.cgi?sf=57997 ...
  25. immunoglobulin superfamily domain assignments domain assignments in legionella pneumophila paris
    supfam.mrc-lmb.cam.ac.uk/SUPERFAMILY/cgi-bin/genome.cgi?sf=4 ...
  26. uc davis department of medical microbiology & immunology: satya dandekar, ph.d
    www.ucdmc.ucdavis.edu/medmicro/staff/dandekar.html
  27. environmental enrichment and psychological well-being
    www.brown.edu/Research/Primate/enrich.html

Research Grants62

  1. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2008
    ..and immunological similarities between chronic inflammation of gastrointestinal tract in rhesus macaques (Macaca mulatta) and humans, suggesting the potential use of the non-human primates as a model for this NIDDK-relevant disease...
  2. Transplant Tolerance in Non-Human Primates
    Christian P Larsen; Fiscal Year: 2008
    ..By taking advantage of our ability to induce chimerism using mobilized peripheral blood stem cells from living Rhesus macaque donors, we propose to perform a systematic analysis of impact of a costimulation blockade and chimerism-based ..
  3. SEQUENCE AND POLYMORPHISM OF RHESUS MACAQUE MHC
    Daniel E Geraghty; Fiscal Year: 2006
    The increased utility of the rhesus macaque animal model in both HIV vaccine development and pathogenesis studies necessitates the development of a solid genetics and immunogenetics data infrastructure for this species...
  4. Prevention of AIDS
    Barbara Felber; Fiscal Year: 2006
    ..native and modified antigens are able to induce immune responses able to protect from high viremia in the rhesus macaque/SIVmac251 model. Current studies examine the role of these DNA vaccines as therapeutic modalities...
  5. Bone marrow monocyte output and virus import into the CNS in acute SIV infection
    Ursula Esser; Fiscal Year: 2008
    ..marrow production of monocytes during acute inflammation and functionality of newly emerging monocytes in the rhesus macaque animal model for Acquired Immunodeficiency Syndrome (AIDS)...
  6. A Rhesus Macaque Model of SIV-Malaria Co-Infection
    Kristina Abel; Fiscal Year: 2008
    ..Thus, we propose to establish a rhesus macaque co-infection model of SIV and the simian parasite Plasmodium fragile to closely mimic HIV-P...
  7. Cellular Immune Responses Induced by SIVdelta-vif plus IL-15 DNA Vaccine
    ELLEN ELIZABETH SPARGER; Fiscal Year: 2008
    ..Furthermore we investigated the adjuvant activity of a rhesus macaque interleukin (IL)-15 expression plasmid when co-inoculated with the SIV?vif proviral DNA...
  8. Design of Antiviral Drugs Effective Against the HIV-1 Vi
    Ettore Appella; Fiscal Year: 2006
    ..Recently, we have tested one thioester, SAMT-247, in the Simian/Human Immunodeficiency Virus (SHIV)/rhesus macaque model of HIV-1 transmission in collaboration with Dr...
  9. GM-CSF-Adjuvanted Clade C DNA/MVA and MVA/MVA Vaccines
    Harriet L Robinson; Fiscal Year: 2008
    ..Dr. Rama Amara (at Emory) will lead preclinical studies in the SIV251/rhesus macaque model. Dr...
  10. HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTION
    Changyi Chen; Fiscal Year: 2004
    ..A novel artery culture perfusion model (C. Chen R01) and a rhesus macaque model (H...
  11. Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    Jay V Solnick; Fiscal Year: 2007
    ..of elegant studies, and the Solnick lab, which has developed and exploited the specific pathogen free (SPF) rhesus macaque model of H. pylori...
  12. Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    Jay V Solnick; Fiscal Year: 2008
    ..of elegant studies, and the Solnick lab, which has developed and exploited the specific pathogen free (SPF) rhesus macaque model of H. pylori...
  13. Comparison of shape coding in somatosensory and visual cortex
    Jeffrey M Yau; Fiscal Year: 2008
    ..is to investigate neural mechanisms underlying 2D form processing in the brain of the awake rhesus monkey (Macaca mulatta)...
  14. Recombinant antigen assays for Lassa and other arenaviru
    Robert F Garry; Fiscal Year: 2005
    ..Specific Aim 1 is to clone cell lines producing murine and rhesus macaque monoclonal antibodies (MAb) specific for LASV glycoproteins and nucleoprotein...
  15. Monocyte Brain Infiltration in Acute SIV Infection
    Ursula Esser; Fiscal Year: 2006
    ..The rhesus macaque AIDS model is the best available animal model to study neurological complications and the development of neuro-..
  16. Dendritic Cell Dynamics in Peripheral and Lymphoid Tissues in SIV Infection
    Simon M Barratt-Boyes; Fiscal Year: 2008
    ..However, the effects of infection on DC subsets in lymphoid tissues remain largely unexplored. Using the rhesus macaque/simian immunodeficiency virus (SIV) model, we have shown that DC numbers are increased in lymph nodes at the ..
  17. Dendritic Cell Dynamics in Peripheral and Lymphoid Tissues in SIV Infection
    Simon M Barratt-Boyes; Fiscal Year: 2007
    ..However, the effects of infection on DC subsets in lymphoid tissues remain largely unexplored. Using the rhesus macaque/simian immunodeficiency virus (SIV) model, we have shown that DC numbers are increased in lymph nodes at the ..
  18. Genetically Defined Herpes/Retrovirus SPF Macaques
    Nicholas W Lerche; Fiscal Year: 2008
    ..Genetic and immunologic data obtained from this project will better define and characterize the rhesus macaque model system in support of research on AIDS and other infectious diseases. ..
  19. A Novel Oral Combination Pediatric HIV and TB Vaccine
    KRISTINA (Contact) ABEL; Fiscal Year: 2008
    ..We will test hypothesis in the rhesus macaque model of infant oral SIV infection...
  20. SIV MACAQUE MODEL FOR BREAST MILK TRANSMISSION OF HIV
    Angela M Amedee; Fiscal Year: 2003
    ..and immunological variables involved in HIV transmission via breast milk, we will utilize the SIV-infected rhesus macaque model for mother-to- infant transmission and a well characterized virus inoculum, SIV/ DeltaB670...
  21. ENTERIC VIRAL INFECTIONS OF CAPTIVE RHESUS MACAQUES
    Karol Sestak; Fiscal Year: 2008
    ..As the success of the rhesus macaque model of human disease have resulted in increased use of disease- and genetically-defined animals, the demand ..
  22. BRAIN INFECTION WITH NEUROVIRULENT SIV IN MACAQUES
    Paul D Cheney; Fiscal Year: 2002
    ..We will test this hypothesis in SIVmac infected rhesus macaque model by taking advantage of recent advances in multi-electrode array implant technology to record multiple ..
  23. Development of RhCMV Vectors for SIV Infection
    Louis J Picker; Fiscal Year: 2008
    ..The overall goal of this proposal is to use the rhesus macaque (RM) model (RhCMV/SIV) to explore the hypothesis that the special adaptations of CMV vectors (immunogenicity, ..
  24. Gamma-2 Herpesviruses as Vaccine Vectors for AIDS
    Ronald C Desrosiers; Fiscal Year: 2007
    ..B lymphocyte, gene expression, latent virus infection, monocyte, nonhuman therapy evaluation, plasmid, recombinant DNA, vaccine evaluation, virus infection mechanism, virus load Macaca mulatta, biotechnology, flow cytometry
  25. EFFECT OF HIV PROTEASE INHIBITORS ON ENDOTHELIAL DYSFUNC
    Harold M McClure; Fiscal Year: 2004
    ..A novel artery culture perfusion model (C. Chen R01) and a rhesus macaque model (H...
  26. ER beta selective agonist coronary protection-menopause
    R Kent Hermsmeyer; Fiscal Year: 2005
    ..newly discovered endogenous ERbeta Agonist (ErbetaA or ERbA) will be studied in adult female and male rhesus (Macaca mulatta) in the catheterization laboratory, and in VMC isolated from rhesus coronary arteries...
  27. Role of type I interferons in mucosal anti-SIV immunity
    Kristina Abel; Fiscal Year: 2005
    ..The rhesus macaque model of SIV infection provides us with a model to study innate and adaptive host immune responses induced ..
  28. Response of Rhesus Sperm to Freezing: Recovery from Osmotic and Oxidative Stress
    Stuart A Meyers; Fiscal Year: 2008
    DESCRIPTION (provided by applicant): Efficient preservation of genetic resources of the rhesus monkey (Macaca mulatta) is critical to the mission of the National Center for Research Resources...
  29. Establishment of SPF Rhesus Macaque Breeding Colony
    Keith G Mansfield; Fiscal Year: 2008
    DESCRIPTION (provided by applicant): The SIV-infected rhesus macaque has emerged as the premiere animal model of human AIDS and has lead to important advances in understanding aspects of disease pathogenesis, the role of viral ..
  30. Establishment of SPF Rhesus Macaque Breeding Colony
    Keith G Mansfield; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): The SIV-infected rhesus macaque has emerged as the premiere animal model of human AIDS and has lead to important advances in understanding aspects of disease pathogenesis, the role of viral ..
  31. Response of Rhesus Sperm to Freezing: Recovery from Osmotic and Oxidative Stress
    Stuart A Meyers; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Efficient preservation of genetic resources of the rhesus monkey (Macaca mulatta) is critical to the mission of the National Center for Research Resources...
  32. Lyme neuroborreliosis pathogenesis in the rhesus monkey
    MARIO TOMAS PHILIPP; Fiscal Year: 2008
    ..burgdorferi. The following specific aims are proposed, using the rhesus macaque, the only animal model of LB of the CNS: SA-1: Experiments in vivo...
  33. Lyme neuroborreliosis pathogenesis in the rhesus monkey
    MARIO TOMAS PHILIPP; Fiscal Year: 2007
    ..burgdorferi. The following specific aims are proposed, using the rhesus macaque, the only animal model of LB of the CNS: SA-1: Experiments in vivo...
  34. Host specific responses in SIV-induced hematosuppression
    Guido Silvestri; Fiscal Year: 2006
    ..In contrast, SIV infection of the non-natural rhesus macaque (RM) host, recapitulates the BM suppression and lymphopenia seen in human AIDS...
  35. Host specific responses in SIV-induced hematosuppression
    Guido Silvestri; Fiscal Year: 2007
    ..In contrast, SIV infection of the non-natural rhesus macaque (RM) host, recapitulates the BM suppression and lymphopenia seen in human AIDS...
  36. Pathobiology of SAIDS-Associated Lymphomas
    Laura S Levy; Fiscal Year: 2006
    ..Simian AIDS (SAIDS) in the rhesus macaque offers a useful and informative animal model for this disease...
  37. The Immunogenetics of Macaques Used in Biodefense Research
    Alessandro Sette; Fiscal Year: 2008
    DESCRIPTION (provided by applicant): Rhesus macaques (Macaca mulatta) and Cynomolgus macaques (Macaca fascicularis), are widely used as models of disease pathogenesis in humans and for evaluating vaccines and therapeutics against ..
  38. STUDY OF MHC & CTL IN OPIATE-DEPENDENT MONKEYS WITH AIDS
    David I Watkins; Fiscal Year: 2002
    ..Additionally, they will determine whether the MHC of the rhesus macaque can play a role in resistance to SIV infection in vivo...
  39. Pathobiology of SAIDS-Associated Lymphomas
    Laura S Levy; Fiscal Year: 2006
    ..Simian AIDS (SAIDS) in the rhesus macaque offers a useful and informative animal model for this disease...
  40. Plasticity of the Visual Cortex
    Stelios M Smirnakis; Fiscal Year: 2006
    ..of reorganization triggered by an acute retinal scotoma in the visual cortex of human and non-human primates (macaca mulatta)...
  41. Replication and Persistence of Primate Lentiviruses
    Welkin E Johnson; Fiscal Year: 2007
    ..Experiments in specific aim #1 will focus on characterizing the antibody response in an infected rhesus macaque with an unusually high-titer neutralizing antibody response against SIVmac239...
  42. Replication and Persistence of Primate Lentiviruses
    Welkin E Johnson; Fiscal Year: 2008
    ..Experiments in specific aim #1 will focus on characterizing the antibody response in an infected rhesus macaque with an unusually high-titer neutralizing antibody response against SIVmac239...
  43. Neurokinin-1R (SP Receptor) Antagonists for HIV Therapy
    Steven D Douglas; Fiscal Year: 2008
    ..and therapeutic potential of an NK-1R antagonist (aprepitant or alternative) in SIV infection in the Rhesus macaque (Project 3)...
  44. Genetic basis of behavior in Macaca
    David Goldman; Fiscal Year: 2006
    ..and sequenced the highly conserved 5HT1A gene from four macaque species (Macaca fascicularis , Macaca maura, Macaca mulatta and Macaca nemestrina) and from the vervet monkey (Cercopithecus aethiops)...
  45. CORE--ANIMALS
    GREGORY JOHN BAGBY; Fiscal Year: 2008
    ..on simian immunodeficiency virus (SIV) disease transmission, pathogenesis, progression and treatment in the rhesus macaque (Macaca mu/atta) by Research Components and Pilot Projects of our Alcohol Research Center (ARC)...
  46. Substance P and NK1R Antagonists in Simian AIDS
    Andrew A Lackner; Fiscal Year: 2008
    The rhesus macaque infected with the simian immunodeficiency virus (SIV) is the premier animal model for the study of AIDS pathogenesis in general and of the neuropathogenesis of AIDS in particular...
  47. Signal transduction pathways involved in adult cortical plasticity
    JOHN THOMAS PENA; Fiscal Year: 2008
    ..Currently our laboratory has developed reliable methods to alter gene expression in the adult Macaca mulatta visual cortex using nonreplicative adeno-associated virus bearing a gene for enhanced green fluorescent ..
  48. ROLE OF AN ANTIAPOPTOTIC AGENT IN AIDS PROGRESSION
    Maria S Salvato; Fiscal Year: 2002
    ..Our studies in the SIV/rhesus macaque model for AIDS implicate FasL-mediated cell death as a possible accelerator of disease progression in AIDS...
  49. CTL-BASED VACCINES FOR THE AIDS VIRUS
    David I Watkins; Fiscal Year: 2003
    ..In this proposal we will determine the role of CTL in control of viral replication using the SIV-infected rhesus macaque as an animal model for HW-infected humans...
  50. MODEL FOR PELVIC FLOOR DISORDERS
    Amanda L Clark; Fiscal Year: 2004
    ..The work proposed addresses the role of steroid hormones, aging and parity in the rhesus macaque vagina...
  51. PERIPHERAL VIRAL LOAD AND SIV-INDUCED CNS DYSFUNCTION
    Howard S Fox; Fiscal Year: 2003
    ..This group proposes to use an SIV-rhesus macaque model to test their hypothesis that CNS virus-associated pathology can be blocked, limited or reversed by the ..
  52. IN VIVO MOLECULAR ANALYSIS OF SIV LUNG INFECTIONS
    Todd A Reinhart; Fiscal Year: 2002
    ..an experimental plan to comprehensively characterize the virologic and immunologic outcomes of infection in rhesus macaque lung tissues by SIV during the acute, clinically latent, and terminal stages of disease...
  53. Immune Responses and Protection in Rhesus Macaques
    Amitinder Kaur; Fiscal Year: 2008
    ..Although several vaccine approaches are being tested for efficacy in the SIV/rhesus macaque model, the immunologic requirements of effective anti-HIV immunity remain largely unknown...
  54. Role of Memory T Cell Dynamics in SIV Infection
    Louis J Picker; Fiscal Year: 2008
    DESCRIPTION (provided by applicant): HIV and its rhesus macaque (RM) counterpart SIVmac239 share a pattern of infection and a constellation of pathobiologic features that, in the vast majority of susceptible (untreated) people or RM, ..
  55. Visual Processing and Smooth Eye Movements
    Michael J Mustari; Fiscal Year: 2008
    ..animal models for studying the development of the visual and oculomotor systems by raising infant monkeys (Macaca mulatta) with either surgical or prism induced strabismus...
  56. A preclinical large animal model for globin gene transfe
    John Tisdale; Fiscal Year: 2006
    ..of lentiviral gene transfer vectors carrying human ?O-globin along with key regulatory sequences in the rhesus macaque model. A number of other issues, however, remain to be addressed prior to clinical application...
  57. CD4+ T CELL FUNCTION IN SIV-INFECTED MACAQUES
    R Paul Johnson; Fiscal Year: 2002
    ..We therefore propose to use the rhesus macaque model to further explore the role of CD4+ T cell help in host immune responses to SIV...
  58. VACCINE APPROACHES TO PREVENT HIV/AIDS IN CHILDREN
    Marta L Marthas; Fiscal Year: 2003
    ..This proposed project will use the SIV/neonatal rhesus macaque model of human pediatric HIV/AIDS to generate information needed to fill important gaps in developing an HIV ..
  59. Novel Carrier for Polysaccharide Conjugates and an EBV Vaccine
    Clifford M Snapper; Fiscal Year: 2008
    ..The proposed studies, using the rhesus macaque as an in vivo model, will determine the feasibility of using the EBV envelope protein, gp350, an intrinsically ..
  60. CHEMOKINE RECEPTORS IN THE NEUROPATHOGENESIS OF AIDS
    Andrew A Lackner; Fiscal Year: 2003
    ..2. Characterize chemokine receptor expression in immediately ex vivo and in vitro populations of rhesus macaque neurons and astrocytes. 3. Evaluate the effects of chemokine receptor stimulation on neurons and glial cells...
  61. A Novel Model for the Study of Lung Pathogenesis of SARS
    Linqi Zhang; Fiscal Year: 2008
    ..term overall objective is to understand the pulmonary pathogenesis using SARS-CoV infected Chinese macaque (Macaca mulatta) as an animal model...
  62. RNA directed silencing of HIV and SIV receptors
    Michael F Murray; Fiscal Year: 2004
    ..This proposal seeks to investigate whether hematopoietic stem cells (HSC) from human peripheral blood and from rhesus macaque bone marrow can be transduced with retroviral vectors that will continue to deliver hpRNA following ..

Publications62

  1. Redundancy reduction and sustained firing with stochastic depressing synapses
    Mark S Goldman
    Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 22:584-91
    ..This leads to a prediction for the number and latency distribution of the inputs that typically drive a cortical neuron...
  2. Neuronal activity in primate dorsolateral and orbital prefrontal cortex during performance of a reward preference task
    Jonathan D Wallis
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, E25 236, 45 Carleton Street, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Eur J Neurosci 18:2069-81
    ..To compare and contrast their roles, we recorded simultaneously from both areas while two rhesus monkeys (Macaca mulatta) performed a reward preference task...
  3. Prefrontal cortex activity related to abstract response strategies
    Aldo Genovesio
    Neuron 47:307-20
    ..These findings indicate that the prefrontal cortex contributes to the implementation of the abstract response strategies that monkeys use during trial-and-error learning...
  4. Contributions of prefrontal cue-, delay-, and response-period activity to the decision process of saccade direction in a free-choice ODR task
    Kei Watanabe
    Department of Cognitive and Behavioral Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    Neural Netw 19:1203-22
    ..The gradual increase of the directional selectivity in delay-period activity might correspond to neural correlates of the decision process of the saccade direction in the S-ODR task...
  5. Impact of experience on the representation of object-centered space in the macaque supplementary eye field
    David E Moorman
    Center for the Neural Basis of Cognition, Mellon Institute, Room 115, 4400 Fifth Avenue, Pittsburgh, PA 15213 2683, USA
    J Neurophysiol 97:2159-73
    ..We conclude that neural representations of object-centered space, naturally present in the primate brain, can be sharpened by training...
  6. Action and outcome encoding in the primate caudate nucleus
    Brian Lau
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 27:14502-14
    ..Thus, striatal neurons active primarily after a movement appear to be segregated into two distinct groups that provide complimentary information about the outcomes of actions...
  7. Deficits in saccade target selection after inactivation of superior colliculus
    Robert M McPeek
    The Smith Kettlewell Eye Research Institute, 2318 Fillmore Street, San Francisco, California 94115, USA
    Nat Neurosci 7:757-63
    ..Our results indicate that, in addition to its well-established involvement in movement execution, the SC has an important functional role in target selection...
  8. Neural activity in monkey prefrontal cortex is modulated by task context and behavioral instruction during delayed-match-to-sample and conditional prosaccade-antisaccade tasks
    Kevin Johnston
    Department of Physiology and Pharmocology, University of Western Ontario, London, ON, Canada
    J Cogn Neurosci 18:749-65
    ..These data show that activity in PFC neurons is modulated by experimental context, and that this activity represents the formal demands of the task currently being performed...
  9. Rule-dependent activity for prosaccades and antisaccades in the primate prefrontal cortex
    Stefan Everling
    University of Western Ontario, London, Canada
    J Cogn Neurosci 17:1483-96
    ..The activity of these neurons also discriminated between correct responses and errors. We hypothesize that the PFC provides bias signals to saccade-related areas that are necessary to preset the oculomotor system for different tasks...
  10. Dynamic circuitry for updating spatial representations. III. From neurons to behavior
    Rebecca A Berman
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsbirgh, Pittsburgh, PA, USA
    J Neurophysiol 98:105-21
    ..These findings indicate that remapping activity in area LIP is present in the split-brain monkey for the double-step task and covaries with spatial behavior on within-hemifield compared to across-hemifield sequences...
  11. Temporal processing of saccade targets in parietal cortex area LIP during visual search
    Neil W D Thomas
    Neuroscience Graduate Program, Centre for Neuroscience Studies, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Neurophysiol 97:942-7
    ..These findings suggest that LIP activity reflects the selection of both the search target and the targeting saccade during active visual search...
  12. Neuronal activity in primate orbitofrontal cortex reflects the value of time
    Matthew R Roesch
    Center for the Neural Basis of Cognition, Mellon Institute, University of Pittsburgh, Pennsylvania, USA
    J Neurophysiol 94:2457-71
    ..We conclude that neuronal activity in OF represents the time-discounted value of the expected reward...
  13. Spatial updating in area LIP is independent of saccade direction
    Laura M Heiser
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurophysiol 95:2751-67
    ..Our findings support the hypothesis that the activity of LIP neurons contributes to the maintenance of spatial constancy throughout the visual field...
  14. Priming in macaque frontal cortex during popout visual search: feature-based facilitation and location-based inhibition of return
    Narcisse P Bichot
    Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 22:4675-85
    ..These results show adjustments of the target selection process in FEF corresponding to and therefore possibly contributing to changes in performance across trials caused by sequential regularities in display properties...
  15. Responses of neurons in the lateral intraparietal area to central visual cues
    Brian E Russ
    Department of Psychological and Brain Sciences and Center for Cognitive Neuroscience, Dartmouth College, 6207 Moore, Hanover, NH 03755, USA
    Exp Brain Res 174:712-27
    ..In both tasks, LIP activity was modulated by these non-spatial cues. These observations further suggest a role for area LIP in mediating endogenous associations that link stimuli with actions...
  16. Engagement of visual fixation suppresses sensory responsiveness and multisensory integration in the primate superior colliculus
    A H Bell
    Centre for Neuroscience Studies, Department of Physiology, Queen's University, Kingston, Ontario, Canada K7L 3 N6
    Eur J Neurosci 18:2867-73
    ....
  17. Single trial-based prediction of a go/no-go decision in monkey superior colliculus
    Ryohei P Hasegawa
    Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Neural Netw 19:1223-32
    ..Post hoc analyses by VDF correctly predicted the monkey's choice in more than 80% of trials. These results suggest that monitoring of SC activity has sufficient capacity to predict go/no-go decisions on a trial-by-trial basis...
  18. Comparison of saccade-associated neuronal activity in the primate central mesencephalic and paramedian pontine reticular formations
    Jason A Cromer
    University of Connecticut Health Center, Department of Neurology, Farmington, Connecticut 06030, USA
    J Neurophysiol 98:835-50
    ..However, we also found novel vectorial eye velocity encoding neurons that may have important implications for saccade control...
  19. Microstimulation of macaque area LIP affects decision-making in a motion discrimination task
    Timothy D Hanks
    Howard Hughes Medical Institute, National Primate Research Center, and Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    Nat Neurosci 9:682-9
    ..Microstimulation never directly evoked saccades, nor did it change reaction times in a simple saccade task. These results demonstrate that the discharge of LIP neurons is causally related to decision formation in the discrimination task...
  20. Attention modulates the responses of simple cells in monkey primary visual cortex
    Carrie J McAdams
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 25:11023-33
    ....
  21. Comparison of neuronal activity in the rostral supplementary and cingulate motor areas during a task with cognitive and motor demands
    D Akkal
    Laboratoire de Neurophysiologie, UMR CNRS, 5543, Université Victor Segalen, 146, rue Léo Saignat, 33076 Bordeaux, France
    Eur J Neurosci 15:887-904
    ..Their functional properties reflect their anatomical positions, which give them the potential to integrate external stimuli (pre-SMA) and internal states (CMAr) during motor planning...
  22. Integrating motion and depth via parallel pathways
    Carlos R Ponce
    Harvard MIT Division of Health Sciences and Technology, Harvard Medical School, 260 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 11:216-23
    ....
  23. Relation of frontal eye field activity to saccade initiation during a countermanding task
    Joshua W Brown
    Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Exp Brain Res 190:135-51
    ..The results also validate these analytical procedures for identifying signals that control saccade initiation in other brain structures...
  24. Neuronal activity representing visuospatial mnemonic processes associated with target selection in the monkey dorsolateral prefrontal cortex
    Michiyo Iba
    Laboratory of Neurobiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurosci Res 43:9-22
    ....
  25. Neuronal activity in monkey primary somatosensory cortex is related to expectation of somatosensory and visual go-cues
    Yu Liu
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Exp Brain Res 177:540-50
    ..Most SI neurons were biased to only one sensory modality. The expectation-related FR changes suggest different involvement by SI in movement initiation when tasks are guided by vibratory and visual signals...
  26. Background changes delay information represented in macaque V1 neurons
    Xin Huang
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    J Neurophysiol 94:4314-30
    ..In the changing-background condition, and presumably in natural vision, temporal changes are widely distributed. Thus a delayed representation of visual information may be more representative of natural visual situations...
  27. Object perception in natural scenes: encoding by inferior temporal cortex simultaneously recorded neurons
    Nikolaos C Aggelopoulos
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, United Kingdom
    J Neurophysiol 93:1342-57
    ..Furthermore, it was shown that there was little redundancy (6%) between the information provided by the spike counts of the simultaneously recorded neurons, making spike counts an efficient population code with a high encoding capacity...
  28. Monkey primary somatosensory cortical activity during the early reaction time period differs with cues that guide movements
    Yu Liu
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Exp Brain Res 187:349-58
    ..The DEEP neurons may be tuned before movement initiation for processing information encoded by proprioceptive afferents...
  29. Macaque V1 activity during natural vision: effects of natural scenes and saccades
    Sean P MacEvoy
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    J Neurophysiol 99:460-72
    ....
  30. Estimating invisible target speed from neuronal activity in monkey frontal eye field
    Andrei Barborica
    Department of Psychiatry, Center for Neurobiology and Behavior, and David Mahoney Center for Mind and Brain, Columbia University, 1051 Riverside Dr, Kolb Annex 504, New York, New York 10032, USA
    Nat Neurosci 6:66-74
    ..FEF may therefore be involved in updating an internal representation of target trajectory for predictive saccades...
  31. Neural activity in the frontal eye fields modulated by the number of alternatives in target choice
    Kyoung Min Lee
    Smith Kettlewell Eye Research Institute, San Francisco, California 94115, USA
    J Neurosci 28:2242-51
    ..These findings support the area's involvement in sensory-motor translation for target selection through coactivation and competitive interaction of neural populations that code for alternative action sets...
  32. Posterior parietal cortex encodes autonomously selected motor plans
    He Cui
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 56:552-9
    ..Such differential activity associated with effector choice under identical stimulus conditions provides definitive evidence that the PPC is prospectively involved in action selection and movement preparation...
  33. Combination of neuronal signals representing object-centered location and saccade direction in macaque supplementary eye field
    David E Moorman
    Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213 2683, USA
    J Neurophysiol 97:3554-66
    ..The results suggest that the SEF is at a transitional stage between representing the object-centered command and specifying the parameters of the saccade...
  34. The sensory nature of mnemonic representation in the primate prefrontal cortex
    C Constantinidis
    Section of Neurobiology, Yale School of Medicine, New Haven, Connecticut 06510, USA
    Nat Neurosci 4:311-6
    ....
  35. Limb-specific representation for reaching in the posterior parietal cortex
    Steve W C Chang
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 28:6128-40
    ..The current study therefore provides novel evidence that the PRR operates as a limb-dependent stage that lies further along the sensory-motor transformation for visually guided reaching than previously expected...
  36. Timecourse of object-related neural activity in the primate prefrontal cortex during a short-term memory task
    Gregor Rainer
    Center for Learning and Memory, RIKEN MIT Neuroscience Center, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Eur J Neurosci 15:1244-54
    ..These results suggest that PF delay activity does not merely maintain recent sensory input, but is subject to more complex experience-dependent dynamics. This has implications for how delay activity is generated and maintained...
  37. Neural correlates of target choice for pursuit and saccades in the primate superior colliculus
    Richard Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 35:355-63
    ..These results show that activity from the same set of neurons in the superior colliculus can predict target choices for both pursuit and saccades...
  38. Neural selectivity in anterior inferotemporal cortex for morphed photographic images during behavioral classification or fixation
    Yan Liu
    Department of Physiology and Biophysics, University of Washington, Box 357330, Seattle, WA 98115, USA
    J Neurophysiol 100:966-82
    ..Our findings show that many neurons in aIT could provide sensory information sufficient for the classification of images when a 2AFC-DMS task was performed...
  39. Pre-excitatory pause in frontal eye field responses
    T Sato
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Exp Brain Res 139:53-8
    ..This pre-excitatory pause, which has been observed in striate and extrastriate visual areas, may represent a resetting of neural activation for detailed visual processing or saccade preparation...
  40. Time course of a repetition effect on saccadic reaction time in non-human primates
    J L Gore
    Centre for Neuroscience Studies, Department of Physiology, Queen s University, Kingston, ON, Canada K7L 3N6
    Arch Ital Biol 140:203-10
    ..Additionally, we have shown a robust time course of this repetition effect, revealing that it exists for only a limited amount of time...
  41. Saccade target selection in the superior colliculus during a visual search task
    Robert M McPeek
    The Smith Kettlewell Eye Research Institute, San Francisco, California 94115, USA
    J Neurophysiol 88:2019-34
    ..This suggests that certain types of SC neurons participate in the target selection process and that the SC as a whole represents a gateway for target selection signals to be converted into a saccadic command...
  42. Neuronal activity in the rostral superior colliculus related to the initiation of pursuit and saccadic eye movements
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:4333-44
    ..These results suggest how SC neurons may coordinate the initiation of pursuit and saccades: buildup activity may gate the initiation of pursuit, whereas it indirectly triggers saccades by recruiting a saccade-related burst...
  43. Neuronal activity related to elapsed time in prefrontal cortex
    Aldo Genovesio
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Building 49, Room B1EE17, 49 Convent Drive, MSC 4401, Bethesda, MD 20892-4401, USA
    J Neurophysiol 95:3281-5
    ..This delay-dependent activity varied only weakly with reaction time and instead appeared to reflect a more general aspect of elapsed time...
  44. Competitive stimulus interactions within single response fields of superior colliculus neurons
    Xiaobing Li
    Department of Physiology, University of Wisconsin-Madison Medical School, Madison, Wisconsin 53706, USA
    J Neurosci 25:11357-73
    ..We conclude that cues to shift gaze, like attention, modulate the influence of sensory interactions, providing additional support for the linkage between attention and saccade selection...
  45. Attentional modulation of behavioral performance and neuronal responses in middle temporal and ventral intraparietal areas of macaque monkey
    Erik P Cook
    Howard Hughes Medical Institute and Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:1994-2004
    ..Where this relationship is preserved may indicate which cortical regions are most closely associated with the behavior in a given task...
  46. Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus
    J K Marcario
    Departments of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160 7185, USA
    J Neurovirol 10:387-99
    ....
  47. Visual-vestibular interactive responses in the macaque ventral intraparietal area (VIP)
    Frank Bremmer
    Laboratoire de Physiologie de la Perception et de l Action, CNRS Collège de France, 11 place Marcelin Berthelot, F 75231 Paris Cedex 05, France
    Eur J Neurosci 16:1569-86
    ..These results, taken together with data on responses to optic flow stimuli obtained in a parallel study, strongly suggest an involvement of area VIP in the analysis and the encoding of self-motion...
  48. Visual responses in the temporal cortex to moving objects with invariant contours
    Yusuke Z Tanaka
    Department of Behavioral and Brain Sciences, Primate Research Institute, Kyoto University, Inuyama, Japan
    Exp Brain Res 146:248-56
    ..The results may also suggest the functional segregation of selective versus non-selective neurons and the later arrival of directional response to MS neurons in the STS...
  49. Perceptual grouping correlates with short synchronization in monkey prestriate cortex
    Thomas Woelbern
    Philipps-University, Physics Department, Neurophysics Group, Marburg, Germany
    Neuroreport 13:1881-6
    ..These are first indications that a short synchronous burst in V2 may support perceptual grouping...
  50. Trajectory interpretation by supplementary eye field neurons during ocular baseball
    Yong-Guk Kim
    The Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115, USA
    J Neurophysiol 94:1385-91
    ..The results suggest that the SEF can interpret sensory signals about target motion in the context of a rule to guide voluntary eye movement initiation...
  51. Visual cortex neurons of monkeys and cats: temporal dynamics of the spatial frequency response function
    Robert A Frazor
    Department of Psychology and Center for Perceptual Systems, University of Texas, Austin, TX 78712, USA
    J Neurophysiol 91:2607-27
    ....
  52. Representation of attended versus remembered locations in prefrontal cortex
    Mikhail A Lebedev
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland, USA
    PLoS Biol 2:e365
    ..Instead, PF's delay-period activity probably contributes more to the process of attentional selection...
  53. Neuronal activity representing temporal prediction of reward in the primate prefrontal cortex
    Satoshi Tsujimoto
    Laboratory of Cognitive Neurobiology, Hokkaido University Graduate School of Medicine, N15W7, Kita ku, Sapporo 060 8638, Japan
    J Neurophysiol 93:3687-92
    ..These results suggest that a fraction of neurons in the DLPFC represent the temporal prediction of reward and probably a variety of other future events...
  54. Contribution of the primate superior colliculus to inhibition of return
    Michael C Dorris
    Queen's University, Ontario, Canada
    J Cogn Neurosci 14:1256-63
    ..Our findings demonstrate that the primate SC participates in the expression of IOR; however, the SC is not the site of the inhibition. Instead, the reduced activity in the SC reflects a signal reduction that has taken place upstream...
  55. Comparison of reward modulation in the frontal eye field and caudate of the macaque
    Long Ding
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:6695-703
    ..Thus, both the FEF and basal ganglia may contribute to reward bias in saccade generation, with the FEF providing spatially relevant reward information and the basal ganglia providing additional reward-specific information...
  56. Saccade target selection in the superior colliculus: a signal detection theory approach
    Byounghoon Kim
    Department of Physiology, University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Neurosci 28:2991-3007
    ..Furthermore, ROC area and d' increased as saccade onset approached. Together, the results indicate that SC buildup neuronal activity signals the saccadic eye movement decision...
  57. Spatial properties and functional organization of small bistratified ganglion cells in primate retina
    Greg D Field
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:13261-72
    ..Thus, despite their distinctive morphology and chromatic properties, SBCs exhibit two features of other retinal ganglion cell types: center-surround antagonism and regular mosaic sampling of visual space...
  58. Natural stimulation of the nonclassical receptive field increases information transmission efficiency in V1
    William E Vinje
    Neuroscience Program, University of California at Berkeley, Berkeley, California 94720-1650, USA
    J Neurosci 22:2904-15
    ..These data demonstrate that the nCRF increases the sparseness of the stimulus representation in V1, suggesting that the nCRF tunes V1 neurons to match the highly informative components of the natural world...
  59. Neural correlates of structure-from-motion perception in macaque V1 and MT
    Alexander Grunewald
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 22:6195-207
    ..Together, these results suggest that V1 is not directly involved in the generation of the SFM percept, whereas MT is. The perceptual modulation in V1 may be attributable to top-down feedback from MT...