swine

..In addition, with colleagues, we are developing small animal models (swine HEV in swine, avian HEV in chickens) that, with nonhuman primate models of HEV, provide an unprecedented ..

..have thus far failed to demonstrate that therapeutic angiogenesis is as effective in patients as it is in normal swine and other laboratory animals...

..Aim 3- To test pulp regeneration in a relevant tissue environment in swine. This experimental swine model simulates actual clinical applications in humans using autologous stem cells for ..

..Animal herpesviruses pose a significant economic impact to poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses)...

..Animal herpesviruses are of significant economic importance to poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses)...

..Animal herpes significant economic importance to the poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses)...

..syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been difficult to study...

..syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been difficult to study...

..components (and the cytokines induced) on the severity of a SARS-like respiratory coronavirus (PRCV) infection of swine. Our Specific Aims are: 1) To assess if corticosteroid treatment of PRCV-infected pigs has an impact on cytokines ..

..This hypothesis was initially developed based on work carried out in perinatal swine, in which we demonstrated that the roles of NO and ET-1 in intestinal vascular regulation are substantially ..

..Sapovirus (with species Sapporo virus); (3) Vesivirus (with species, feline calicivirus and vesicular exanthema of swine virus); and (4) Lagovirus (with species rabbit hemorrhagic disease virus and European brown hare syndrome virus)...

..A swine model of Marfan has been a goal for many years but it is only recently that the technology required to develop ..

..A swine model of Marfan has been a goal for many years but it is only recently that the technology required to develop ..

..Studies will utilize adult swine and pregnant sheep...

..lipoprotein-receptor (LDL-R) and steroidogenic acute regulatory protein (StAR) genes in vitro primary cultures of (swine) granulosa and theca cells. Indeed, both genes are under strong transcriptional control...

DESCRIPTION (provided by applicant): Project summary/abstract: This application proposes the generation of a swine model of Spinal Muscular Atrophy (SMA) (pSMN1-/-; hSMN2) using somatic cell nuclear transfer of gene targeted fetal ..

..Once the bench-testing phase is complete, an implantation test will be performed using a miniature swine model. The device will be implanted and tested under anesthesia, and then the animal will be allowed to recover...

..Since there are influenza strains that infect birds, swine, horses and humans and since these host-adapted viruses have different antigenic components, genome reassortment ..

..and in wild geese and ducks congregating on a large MN metropolitan lake to recreational users of the lake; 2) swine influenza viruses (SIV) in swine raised in swine production operations to swine production employees; 3) AIVs, ..

..and in wild geese and ducks congregating on a large MN metropolitan lake to recreational users of the lake; 2) swine influenza viruses (SIV) in swine raised in swine production operations to swine production employees; 3) AIVs, ..

..and in wild geese and ducks congregating on a large MN metropolitan lake to recreational users of the lake; 2) swine influenza viruses (SIV) in swine raised in swine production operations to swine production employees; 3) AIVs, ..

..focus on studying the immunopathogenesis of chronic rejection using clinically relevant large animal (miniature swine) models of heart and lung transplantation...

..by applicant): Apolipoprotein A-IV expression is acutely up-regulated 7-fold by a high-fat diet in newborn swine, suggesting a role in lipid absorption...

..Since there are influenza strains that infect birds, swine, horses and humans and since these host-adapted viruses have different antigenic components, genome reassortment ..

..properties of rhMFG-E8 in normal and septic animals; and 5) determine the efficacy of rhMFG-E8 in a swine model of septic shock...

..Aim # 1 is to define patterns changes in the structure and function of vessels and tubules in the kidneys of swine fed HC diet for 12 weeks...

..Serologic evidence of infection of swine with hepatitis E virus (HEV) was obtained...

..2), their hemodynamic effects (Aim 3), and their rate of extravasation (Aim 4) in rats, and their performance in a swine model of prehospital or military use (Aim 5)...

..One of the factors, KLF13, can both repress and activate the pig LDL-R promoter in swine ovarian and insect SL2 cells...

..Poxviruses are the focus of the majority of the presentations but studies of African Swine Fever Virus, Chlorella Viruses and a variety of iridoviruses are also significant contributions to the meeting...

..In the last 10 years, human influenza has caused severe morbidity among US domestic swine, herds, avian influenza has caused the destruction of large poultry flocks in Virginia and North Carolina, and ..

..Our recent discoveries of swine and avian hepatitis E viruses from pigs and chickens and the demonstrated abilities of cross-species infections by ..

..In a separate study it was recently observed that swine infected with Yersinia enterocolitica are at increased risk to be colonized with Salmonella enterica...

..Mammalian Polymerase (3 (pol p) and African Swine Fever Virus Polymerase X (pol X) provide outstanding model systems to study the molecular mechanism of the DNA ..

..the kidney capsule 2-3 months prior to transplantation of the composite organ into pancreatectomized miniature swine. Transplantation of IKs was found to restore euglycemia to pancreatectomized recipients immediately, and to ..

..continues to expand at MSSM; however, there is also concurrently an increase in the use of large animal species (swine, sheep primarily)...

..To advance our technology to the clinical trials, the efficacy of human AM/AMBP-1 will be investigated in a swine model of sepsis...

..One of the factors, KLF13, can both repress and activate the pig LDL-R promoter in swine ovarian and insect SL2 cells...

..will create a model that mimics many of the abnormalities present in type I diabetic patients, and 2) Ossabaw swine fed an atherogenic diet that will develop a glucose intolerance and insulin resistance similar to type II diabetes...

..the investigators propose to build pre-clinical prototypes of the patch and test it in vitro and in vivo in a swine model, as well as testing impedance in humans. ..

..the kidney capsule 2-3 months prior to transplantation of the composite organ into pancreatectomized miniature swine. Transplantation of IKs was found to restore euglycemia to pancreatectomized recipients immediately, and to ..

..In this proposal, we investigate myocardial gene transfer in adult swine models employing cardiac surgery...

..The research plan will build on the well-established miniature swine model of chimerism and kidney allograft tolerance that has been developed in the laboratory of Dr...

..The research plan will build on the well-established miniature swine model of chimerism and kidney allograft tolerance that has been developed in the laboratory of Dr...

..Mammalian Polymerase (3 (pol p) and African Swine Fever Virus Polymerase X (pol X) provide outstanding model systems to study the molecular mechanism of the DNA ..

..candidate proposes learning: 1) fundamental MRI techniques related to blood vessel imaging and intervention, 2) swine experimental methods, and 3) methods for the responsible conduct of research...

..In aim 3c this same construct is evaluated in a long swine allograft model that closely resembles the long nerve defects encountered clinically and will allow translation to ..

..Air and ground water pollution from swine CAFOs are of particular concern in North Carolina, where industrial hog production has expanded rapidly since the ..

..mechanisms of cardiac protection in the second window of ischemic protection in chronically instrumented conscious swine. The project is based, in part, on the novel observation that either regional cardiac denervation or adrenergic ..

..in transient and chronic lung function impairment after exposure to organic dusts in cotton mills, poultry houses, swine confinement buildings, and saw mills...

..for IND filing with the FDA and will perform efficacy studies to evaluate our MRA reagent using an in vivo swine model of myocardial ischemia and reperfusion. ..

..Using MHC inbred miniature swine, synthetic polymorphic allopeptides, and monoclonal antibodies cross-reactive for swine T cells, we plan to (1) ..

..d. injection technologies will be characterized in an animal model of human skin (swine). The criteria for evaluation will include: 1) magnitude and consistency of i.d...

..We have developed new innovative techniques and novel rodent and translational swine models to address the important issues of mechanisms leading to atherosclerosis in diabetes and the metabolic ..

DESCRIPTION (provided by applicant): Nipah virus infection is an emerging new disease of humans and swine, first described during a 1998-1999 epidemic in Malaysia...

..within the context of pandemic influenza virus development, the nature of human influenza virus infection of swine cells and pigs...

..settings of acute inflammation, and have calibrated distinct variants of this model with data from mice, rats, swine, and humans (University of Pittsburgh Inflammatory Analyte/Modeling Component)...

..settings of acute inflammation, and have calibrated distinct variants of this model with data from mice, rats, swine, and humans (University of Pittsburgh Inflammatory Analyte/Modeling Component)...

..Aim 3. Develop a certifiable source herd of swine for tissue donation...

..that can be used to help establish occupational exposure guidelines for complex organic dusts in swine, poultry, and dairy environments, and to evaluate and develop correction factors for direct-reading aerosol ..

..Using a swine model of postinfarction LV remodeling, the effect of cell transplantation on LV contractile function and ..

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..Depending on the time of sampling, one-third or more of all isolates contained est2 or est1b as single gene or in combination with other pathogenicity genes...

..parasuis were detected. The experimental infection using CD pigs describes a successful method to study this microorganism and confirms the important role that maternal antibodies play in protection against clinical signs and disease...

..It was concluded that oral administration of HCC to piglets was effective in preventing PED virus infection and reduced their mortality...

..parasuis systemic infection was successful in both trials, proving that this model is a viable alternative to specific-pathogen free and cesarean-derived, colostrum-deprived pigs...

..In this study, chickens and swine were evaluated for susceptibility to vacuolar myelinopathy with the intent of developing animal models for ..

..to modify the clinicopathologic expression of Brachyspira hyodysenteriae infection in a laboratory mouse model of swine dysentery. However, this concentration impaired the body weight gain of the mice...

..The relatively high oral exposure used in these experiments compared with feed-borne exposure in the field may explain the absence of an epidemic of spongiform encephalopathy in domestic pigs concurrent with the BSE epidemic in the UK...

..The results of our data suggest that PCV2 preferably infects cultured hepatocytes as observed in the liver of pigs with postweaning multisystemic wasting syndrome...

..Although the chicken isolates were all poultry type with G at position 8,234 of the vanX gene, the pig isolates were all swine type with T at position 8,234 of the vanX gene.

..01) on d 30. These results support the possible use LF as an immunostimulant to improve immune functions and strengthen host defenses and would seem to be a good method for defending weanling piglets from infections and weanling stress...

..In conclusion, SDPP, EYA, ZnO, FA, and AB may have provided passive control to ETEC (K88) infection and potentially enabled young pigs to efficiently utilize a PPI-based diet...

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..01). These results indicate that feeding with SDP improved growth performance and protected against E. coli-induced inflammatory status, and suggest that use of SDP-NM can be considered a valid antibiotic alternative...

..0% versus 60.0% respectively). In conclusion, treatment with 110 mg lincomycin/kg of feed for 21 consecutive days had a beneficial effect on the control of PE in growing pigs...

..Finally, the F4R distribution in the herd should be taken into account to correctly assess efficacy...

..Because this study is one of very few examining the use of liquid feed and co-products inoculated with probiotics to control postweaning E. coli diarrhea, more studies are needed to confirm these results...

Partus induction is an important integrative component of reproduction management in the swine industry. In this context, the question is to what extent the application of uterotonic substances may influence the vitality of piglets...

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..It is concluded that the clinical course of PEDV disease was markedly affected by transplacental infection of PCV2...

..The addition of CMC to cooked white rice increased digesta viscosity and enhanced PWC. Consequently, this diet represents a useful model for studying this condition...

..This may improve performance, as the higher DWG indicates. In contrast, no obvious benefit seems to result from an additional supply of EcF via electrolyte solution when diarrhoea is always present...

..Taken together, these results support the concept that porcine chromaffin cells may offer an alternative xenogeneic cell source for transplants delivering pain-reducing neuroactive substances...

..The mechanism of its protective effect might be related to the increased expression of HSP-70...

..To our knowledge, these vessels have not previously been shown convincingly by histopathological methods to revascularize occluded large arteries such as the aorta...

Pigmented tumors resembling cutaneous melanoma were first reported in Sinclair miniature swine in 1967...

..A total of 11 proteins were recognized, and the corresponding spots on a duplicate gel were excised and identified by MALDI-TOF MS...

..However, it may be important to consider the use of an additional method for the detection of beta2 toxin in non-porcine cpb2-positive isolates when making claims about the role of beta2 in enteritis in non-porcine species...

Bovine viral diarrhea virus (BVDV) in pigs may interfere with the detection and epidemiology of classical swine fever virus (CSFV)...

..However, only the Cya-deficient mutant was able to prime the piglets for the development of a secondary nasal IgM and serum IgG response to FHA after intranasal inoculation with the wild type B. bronchiseptica...

..These findings indicate that nucleolin and beta1 integrin are present on the luminal surface of intestinal epithelia and are potentially accessible as receptors for intimin during EHEC O157:H7 infection...

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..The distribution of lesions corresponded closely with the detection of intranuclear inclusion bodies and PRV antigen. High numbers of TUNEL-positive cells detected in the thymus were associated with thymic atrophy...

..However, other factors, such as soil type and temporal variation, may have also contributed to the differences observed...

..For weaners, use of straw in the pen and high pressure cleaning between batches of weaners had a preventive effect against higher Cryptosporidium oocyst excretion levels...

..Immunostaining with anti-PKR antibody showed a redistribution of PKR from the cytoplasm into nucleoli of infected cells...

..The present text gives a brief introduction to the process of intestinal immunoglobulin absorption in large farm animals and describe some recent results from the author's own studies in pigs, calves and lambs...

..Comparative studies of the pathogenicities of FMD (type O) viruses isolated in Taipei China, the Republic of Korea and Japan, suggest that these viruses might have originated as vaccine strains used in a third country...

..In addition to reviewing the literature attempts are made to identify key unresolved areas that should be the focus of future research...

..Least resistance occurred against ceftiofur for all, followed by apramycin and gentamicin for porcine and florfenicol for bovine isolates. No significant differences were found between the first 8 and last 5 years...

..A survey was performed to detect toroviruses in Hungary by means of sampling ten swine and nine bovine herds...

..Inoculation combined with feeding of large quantities of soybean meal and group-housing induced swine dysentery in all experimental animals...

..HERV-K, in human melanomas, we studied the expression of PERVs in melanomas of selectively bred Munich miniature swine (MMS) Troll...

..Furthermore, despite some regional variation, the risk of exposure declined further after the feed restriction was imposed in 1996...

..residue caused clinical signs and histologic lesions similar than those observed in experimental intoxication of swine with A. indica seeds...

..liver and lungs of all animals, rumen of cattle, small intestine of lambs and kids, and muscles of cattle and swine. The parasitic lesions observed in the lungs of cattle, sheep and goats were caused only by hydatid cysts...

..The animal host-specificity of these STEC is also reviewed. In conclusion some methods of improving isolation of these pathogens is addressed...

..Many sero- and phage types found in humans were also found in cattle, pigs, and poultry suggesting that food producing animals are an important source of human non-typhoid Salmonella infection in Vietnam...

..In pigs, a high prevalence of GBR antibodies (97 %) was detected in sera from sows. These results suggest that GBR infection is common in cattle and pigs, notwithstanding the scarcity of reports of GBR detection in these species to date...

A total of 361 Escherichia coli O157 isolates, recovered from humans, cattle, swine, and food during the years 1985 to 2000, were examined to better understand the prevalence of antimicrobial resistance among these organisms...

..We tested animal fecal samples and identified GIII (bovine), GII.18 (swine), and GII.4 (human) norovirus sequences, demonstrating for the first time, to our knowledge, that GII...

..g. host immune system)...

..Several resistant E. coli bio-types were found to contain the resistance gene. These results indicate that resistance to apramycin and oxytetracycline in E. coli of pigs is affected by previous use of oxytetracycline in sows...

..This multiplex RT-PCR is a simple assay and may be a potentially useful for rapid, sensitive, and cost-effective etiological diagnostic tool for acute viral gastroenteritis in piglets...