sheep

..There have been precedents when vaccines accidentally prepared from tissues of scrapie-infected sheep caused scrapie outbreaks involving hundreds of immunized animals...

..bovine prions and other BSE isolates to transgenic mice expressing PrP from various animal species, including sheep, deer, and human as well as wild type mice and hamsters...

..second, VXI investigated the ability of anti-adhesion coatings to abate fibrotic overgrowth in the hyper-fibrotic sheep model...

..by acute disease isolates similar to the Nine Mile prototype, while chronic isolates and isolates from goat and sheep abortions have been organized into additional groups...

..Progress in this field has been hampered by the cost of the experimental model - the juvenile sheep that has a tissue-engineered valve implanted in the aortic position...

..PUBLIC HEALTH RELEVANCE: Prion diseases are transmissible neurologic disorders that can affect animals (sheep scrapie, cervid chronic wasting disease, bovine spongiform encephalopathy) and humans (Creutzfeldt-Jakob disease ..

..Firstly, they will be tested for anthrax. Human subclasses, and sheep and human anti-anthrax antibodies will be purified as intact, Fab, and Fab2 fragments and studied in terms of ..

..supplement; (3) evaluate the effect of MZF-CaP and MZ-CaP/FF on prevention of bone loss in a larger animal model (sheep); and (4) determine the effects of MZF-CaPs and MZ-CaP/FF on the following levels: (a) molecular (gene expression) ..

..are a group of rare neurodegenerative diseases which include Creutzfeldt-Jakob disease (CJD) in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) and chronic wasting disease (CWD) in mule deer and elk...

..Initially, we plan to study three strains of prions passaged in mice: RML and 301V, which originated from sheep with scrapie and cattle with BSE, respectively, plus a novel synthetic strain MoSP1, which is the most stable ..

..Natural infection has been confirmed only in horses, sheep, cattle, birds, and cats; however, primates can be infected experimentally...

..There have been precedents when vaccines accidentally prepared from tissues of scrapie-infected sheep caused scrapie outbreaks involving hundreds of immunized animals...

..The Mucus Slurper is a novel ETT, with built-in suction ports arranged radially at its tip. In sheep mechanically ventilated for 72 hours, we evaluated safety and efficacy of the Mucus Slurper, compared to ..

..whether monoclonal antibody administration altered systemic immune responses, the antibody response against sheep erythrocytes was evaluated one day following CD4 or CD8 depletion...

..in 1997-98 and spread across the Red Sea to Saudi Arabia and Yemen, causing devastating disease outbreaks in sheep and cattle. The RVFV has potential for use in bioterrorism, and its projected effect on U.S...

..These include chronic wasting disease (CWD) of deer and elk, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jacob disease and kuru in humans...

..In animal TSE, such as scrapie in sheep and bovine spongiform encephalopathy (BSE) in cattle, it is believed that the PrP sc enters the host through the ..

..TSEs, or prion diseases, include Creutzfeldt-Jakob disease, fatal familial insomnia and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk...

..TSEs, or prion diseases, include Creutzfeldt-Jakob disease, fatal familial insomnia and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk...

..a series of experiments in the uterine arteries from nonpregnant and near-term (approximately 140 days) pregnant sheep maintained near sea level (approximately 300m) and at high altitude (3,820 m) from 30 days gestation...

..ability of NCTX (relative to conventional contrast agents) to image thoracic vasculature in a large animal model (sheep)...

..ability of NCTX (relative to conventional contrast agents) to image thoracic vasculature in a large animal model (sheep)...

DESCRIPTION (provided by applicant): We have identified a group of neurons in the arcuate nucleus of the sheep that co-express two neuropeptides: the endogenous opioid peptide, dynorphin A (DYN), and the tachykinin, neurokinin B (NKB)...

..and ovine fetal membranes, and correlate its change to known changes in AF volume dynamics throughout pregnancy in sheep; 2) Investigate the endocrine (oxytocin, prolactin) and second messenger camp regulation of AQPs gene expression ..

..plants and supermarkets where exposure to these transmissible agents occurred from handling cattle, pigs and sheep or their products, and an unexposed control group of 6,078 subjects without such exposures...

..to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the risks of ..

..Studies will utilize adult swine and pregnant sheep. Completion of this investigation will produce clinically-relevant information that will be of significant ..

..plants and supermarkets where exposure to these transmissible agents occurred from handling cattle, pigs and sheep or their products, and an unexposed control group of 6,078 subjects without such exposures...

..These questions will be explored using the sheep as an animal model because of advantages that include the similarity of its estrous cycle to the human menstrual ..

..g., cattle, swine, sheep, goats, horses, fish) as biomedical models, programmatic officials at NIH and USDA, and university administrators; ..

..water samples will be collected during red tide blooms along the southwest Florida coast for exposure to asthmatic sheep by RP3 (Project by Abraham), and for identification and isolation of different species of Karenia by FC1, to ..

..water samples will be collected during red tide blooms along the southwest Florida coast for exposure to asthmatic sheep by RP3 (Project by Abraham), and for identification and isolation of different species of Karenia by FC1, to ..

..to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the risks of ..

..responsible for fatal neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD) in humans, scrapie in sheep, and bovine spongiform encephalopathy (BSE) in cattle...

..chronic wasting disease (CWD) in deer and elk, transmissible mink encephalopathy (TME) in mink, and scrapie in sheep. The infectious agents of TSEs are unconventional, proteinaceous entities, which have been termed prions...

..Based on >16 years of research by our group, studies will be conducted in sheep acclimatized to high altitude (3820 m/12,470 ft). We shall examine a number of hypotheses...

..These questions will be explored using the sheep as an animal model because of advantages that include the similarity of its estrous cycle to the human menstrual ..

..ARDS is associated with organ system failure(MODS). This proposal models ARDS and MODS in a sheep that has a 40% 3rd degree burn with smoke inhalation injury...

TSEs are a group of neurodegenerative diseases affecting a wide variety of mammals including sheep and goats (scrapie), cervid spp. (chronic wasting disease), and humans (Creutzfeldt-Jakob disease)...

..ARDS is associated with organ system failure(MODS). This proposal models ARDS and MODS in a sheep that has a 40% 3rd degree burn with smoke inhalation injury...

..hypotheses, we will perform studies in cerebral arteries of near-term fetuses (approximately 140 gd) and adult sheep that have been acclimatized to high altitude for 3 to 4 months, and also in sea level controls...

..In sheep, cardiomyocytes gradually cease dividing and become binucleated (terminal differentiation) beginning at 100 days ..

..g., anti TNF-1 therapy), our work may lead to new approaches for the treatment of RA. We will also investigate a sheep model of asthma in which L-selectin appears to play a highly novel role (Aim 3)...

..vasospasm after subarachnoid hemorrhage in primates, and decrease pulmonary hypertension in newborn hypoxic sheep. We have also observed that nitrite induces regional vasodialtion in healthy human subjects...

..Thus, in sheep and likely human fetuses, dipsogen-mediated swallowing and antidiuretic responses are present during the last ..

..The sheep will be used because its large size and long lifespan permits individuals to be studied longitudinally through ..

..from blood, bone marrow purging, and for inhibition of transmissible spongiform encephalopathies [bovine (BSE), sheep (scrapie) and human forms (Creutzfeld-Jacob disease)]...

Transmissible spongiform encephalopathies (TSEs) affect a wide range of species including sheep,cattle, mink, humans, deer, elk and others...

..Pregnant sheep will be used as the animal model...

..on hematopoietic stem cells, and that this leads to improved gene transfer to human hematopoietic cells in the sheep xenograft model...

..A combination of small (rat) and large (sheep) animal experiments using dietary restriction before, during and after pregnancy together with studies of human ..

..AAR-IL-8 will be given intravenously as a constant infusion in injured sheep through 48 h. The activation status of neutrophils in lung lymph will be measured by flow cytometry...

..g., anti TNF-1 therapy), our work may lead to new approaches for the treatment of RA. We will also investigate a sheep model of asthma in which L-selectin appears to play a highly novel role (Aim 3)...

..The IFN-t are Type 1 interferons that are expressed and secreted by the embryos of cattle and sheep during early pregnancy and while their precise physiological role remains unclear, there is mounting evidence ..

..3) Perform large animal studies of our new prototype P&P TransApical to Aorta VAD: One-day studies in healthy sheep (n=10) will determine the amount of LV assistance achievable by a P&P TransApical to Aorta VAD and will ..

..We also find that nitrite inhalalation in hypoxic newborn sheep lead to decreased pulmonary artery pressures and exhalation of NO; nitrite infusions in these animals leads to ..

..studies have shown that in late gestation, basal plasma cortisol levels are normal in the long-term hypoxic (LTH) sheep fetus, while expression of key adrenal steroidogenic enzymes (P450 cholesterol side chain cleavage [CYP11A] and ..

..Two major exceptions are the fetal-sheep model and settings where there is a competitive advantage for donor cells as for example in W/W mice and in ..

..to expand at MSSM; however, there is also concurrently an increase in the use of large animal species (swine, sheep primarily)...

..In sheep challenged with smoke inhalation and Pseudomonal pneumonia, INO-1001 significantly increased the PF ratio and ..

..This pathway is constituted by a network of microvessels on the surface of the placenta and, in sheep, within the amnion and chorion as well...

..Dr. Rosenfeld has been studying the structure and distribution of IFN receptor subunits within the uterus of the sheep as her primary project. She currently has a 25% commitment as an instructor in Veterinary Microanatomy. Dr...

..In the present paper, seroprevalence data on T. gondii that have been recorded in livestock from different Italian regions over the last 3 decades are reviewed, showing the high level of exposure of livestock to this parasite...

..The detection of antibodies in milk seems more sensitive than it is in serum...

..Although infection is often unapparent in cattle, sheep and goats, there is increasing evidence that C...

..Since 2002, they have also been used for the post-mortem diagnosis of scrapie in sheep and goat...

Bovine spongiform encephalopathy (BSE) in sheep has not been identified under natural conditions at the time of writing and remains a hypothetical issue...

..These contradictory indicators emphasize that appropriate observation time frames and good discrimination among types of potentially infectious contacts are vital in order for network analysis to be a valuable epidemiological tool...

..the dinical signs, histopathology, detection of PrPSc protein and PrP genetics of the transmission of BSE to sheep and goats, with the effects of the transmission of natural scrapie from a brain homogenate from a single sheep...

Serum samples collected monthly over a 34-month period from cattle, sheep and goats in the Greater Accra Region of Ghana were tested for antibodies to Ehrlichia (previously Cowdria) ruminantium, the causative agent of heartwater, by ..

..mitochondrial cytochrome c oxidase subunit 1 and NADH dehydrogenase 1 genes using Echinococcus isolates of human, sheep, goat, camel, cattle and pig origin from Kenya and Sudan...

..The parasitic lesions observed in the lungs of cattle, sheep and goats were caused only by hydatid cysts. No hydatid cysts were observed in the lungs of swine...

..Hedgehogs, pigs, cats, sheep and goats are now considered to be amplifier hosts, and spread the disease to other species only when inspected or ..

..This initial valuation demonstrates the necessity for increased monitoring and global control of CE...

..infections have only been observed in bovine species in contrast to Babesia divergens that also can infect humans, sheep and rodents...

Four simple and rapid field tests for the serodiagnosis of brucellosis in cattle, goat, sheep and swine were developed...

..Interestingly, as the only T. brucei isolate from sheep in zone III was human-serum-resistant, there may also be a sheep-tsetse-human cycle...

Control and eradication programs of brucellosis in cattle, sheep, goats and pigs have been more or less successfully implemented within the Member States (MS) of the European Union (EU) and Norway after Word War II...

..Cost-related outputs are based on budgets of the value of stock and the cost of mitigations, each of which can be varied by the user. These outputs are a valuable resource to assist with policy development and disease management...

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..The incidence of brucellosis caused by Brucella melitensis in sheep, goats and humans is a very significant problem in Macedonia and Greece...

..When the program started, the prevalence of infection in farm animals was 82% in cattle, 80% in sheep, 24% in goats and 5% in pigs...

..application of indicator traits as well as marker and causal genes in breeding for disease resistance in cattle, sheep, goats and swine...

..Initial seeding of infection was by livestock (predominantly sheep) that had passed through Longtown Market in adjacent Cumbria...

..The possible sources of infection are also examined. Finally, the direct and indirect economic losses are presented...

..Outbreaks among more than 15 Israeli dairy sheep and goat herds presented clinical signs, including gangrenous infections. Characterization of the P...

..The present text gives a brief introduction to the process of intestinal immunoglobulin absorption in large farm animals and describe some recent results from the author's own studies in pigs, calves and lambs...

..The prevalences of infection with Echinococcus granulosus among 1087 sheep, 881 goats, 428 camels and 614 cattle from the same region, determined postmortem in abattoirs, were 20%, 3.4%, 13...

..samples were collected from 60 animal handlers, 175 non-animal handlers and 198 domestic animals (60 cows, 45 sheep, 45 goats, 25 horses and 23 camels)...

..A field trial in Mongolia showed cattle, sheep, goat, reindeer, camel, and human sera without infection could be distinguished from Brucella-infected animals by ..

..Herd-level surveillance along with subsequent risk management action may be a cost-effective component of risk reduction strategies for food production, drinking water supplies and the protection of public health...

..Here the expression of iNOS and synthesis of NO was studied in listeric encephalitis of cattle, sheep, and goats. iNOS was expressed by a subset of Mphi in cerebral microabscesses in all three species...

..The large number of tick species, the multplicity of transmitted agents and the diverse ecoclimatic zones of the Sudan provide a unique opportunity to host diverse research activities that could benefit other regions in Africa...

..A total of 3,250 specimens from a variety of animal species, including domesticated livestock (cattle, sheep, goats, and camels) and wildlife collected from a total of 55 of 71 Kenyan administrative districts, were tested ..

..All sheep and goats were sero-positive for Theileria species by IFAT while 85% of sheep and 100% of goats tested positive ..

..03 for people and 5.2 for livestock in village II. The village variable (P=0.07) and keeping sheep in the household (P=0...

..These risk maps are suitable for use in planning improved sentinel surveillance systems in Senegal, although further data collection is required in large areas of Senegal to better define the spatial distribution of RVF...

The presence of Cryptosporidium oocysts in 460 animals (439 cattle, 16 kids, and 5 sheep) of Tuv-aimak Mongolian district was investigated by IFT. Cryptosporidium oocysts were found in 116 (26.4%) cattle...

..The study involved monthly faecal examinations from sheep, goats and cattle and pasture sampling from eight communal grazing areas...

..The post mortem inspection concerned 2948 sheep, 2337 goats, 618 cattle, 482 camels and 455 equines (325 horses, 60 mules and 70 donkeys) in five different ..

..disease (AD) occurred in a herd of domestic animals that led to the death of seven cattle, three goats, three sheep, two cats and one dog, all of them with CNS signs. The animals were not in direct contact with swine...

..Furthermore, the relative ease with which the cELISA was converted to this platform indicates that this technology is ready to meet the high throughput testing requirements for the diagnosis of many other diseases...

..6%. The presence of the parasite was detected through serology in 14.3% of cattle, 35% of sheep and 68.4% of goats...

Unilocular cysts produced by Echinococcus granulosus were recovered from 110 domestic herbivores (60 sheep, 25 cattle, 20 goats and five camels) slaughtered in Benghazi...

..C-ELISA) has been used for the specific measurement of antibodies to peste des petits ruminants (PPR) viruses in sheep, goats, cattle and buffalo...

..abortus in rams and bucks, respectively. There was no correlation between serology and PCR of semen. The presence of chlamydiae in semen suggests the possibility of venereal transmission, although risk may be low in Switzerland...

There are at least 16 recognised herpesviruses that naturally infect cattle, sheep, goats and various species of deer and antelopes. Six of the viruses are recognised as distinct alphaherpesviruses and 9 as gammaherpesviruses...

Peste des petits ruminants virus (PPRV, genus Morbillivirus), which causes a severe disease in sheep and goats, has only recently been officially declared to be present in Turkey...

..seasonal incidence and distribution of helminth parasites of veterinary importance that occur in cattle, sheep and goats in the northeastern Free State...

Giemsa-stained thin blood smears prepared monthly from cattle, sheep and goats in the Greater Accra region of Ghana between May 1994 and December 1996 were examined for presence of tick-borne haemoparasites...

Strains of Mycoplasma ovine/caprine serogroup 11, isolated from infertile sheep, were compared to the type strain, 2D, and to strains of the cattle pathogen M. bovigenitalium, including the type strain, PG11...

..bovis strain, this alteration has been shown by SDS-PAGE to be associated with a loss of specific protein production. Further study of these phenomena is essential background for the production of more efficient vaccines for mycoplasmas...

..the epidemiology of parasitism in farmed ruminants in the changed agricultural context in Kazakhstan, 505 cattle, sheep and goats were surveyed for gastrointestinal parasitism using coprological examination, and a further thirty sheep ..

During the year 2001, a total of 475 sheep, 200 goats, 135 cattle and 190 camels in El Arich city and El Hassanah center were examined for Babesia ovis and Theileria ovis. Blood films were taken from the vein of the ear...

..The vaccine has proved effective in vaccine trials carried out in sheep in New Zealand, Australia, Argentina, Chile and China as well as in goats and cattle...