ultimobranchial body

Summary

Summary: A diverticulum from the fourth pharyngeal pouch of an embryo, regarded by some as a rudimentary fifth pharyngeal pouch and by others as a lateral thyroid primordium. The ultimobranchial bodies of lower vertebrates contain large amounts of calcitonin. In mammals the bodies fuse with the thyroid gland and are thought to develop into the parafollicular cells. (Stedman, 25th ed)

Top Publications

  1. Miura M, Kameda Y. Neuronal properties in cultured ultimobranchial C cells of chick embryos: process outgrowth and expression of TuJ1 and enkephalin. Brain Res. 2001;905:1-11 pubmed
    ..These results indicate that the C cells cultured from early chick embryos (12- and 13-day-old) maintain the neuronal characteristics for long periods in vitro...
  2. Kusakabe T, Hoshi N, Kimura S. Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid. Dev Dyn. 2006;235:1300-9 pubmed
    The ultimobranchial body (UBB) is an outpocketing of the fourth pharyngeal pouch that fuses with the thyroid diverticulum, giving rise to calcitonin-producing C-cells...
  3. Harach H, Vujanic G, Jasani B. Ultimobranchial body nests in human fetal thyroid: an autopsy, histological, and immunohistochemical study in relation to solid cell nests and mucoepidermoid carcinoma of the thyroid. J Pathol. 1993;169:465-9 pubmed
    The mid portion of the lateral thyroid lobes from 64 fetuses was systematically analysed for the presence of ultimobranchial body nests. The nests showed a prevalence of 1/24 (4.2 per cent) or 13/40 (32...
  4. Kameda Y. Immunocytochemical localization and development of multiple kinds of neuropeptides and neuroendocrine proteins in the chick ultimobranchial gland. J Comp Neurol. 1991;304:373-86 pubmed
    ..Chromogranin A- and neurotensin-immunoreactive cells began to appear at 16 days and 18 days of incubation, respectively. Galanin-, VIP-, and tyrosine hydroxylase-immunoreactive fibers were inconspicuous during embryonic life...
  5. Cameselle Teijeiro J, Varela Duran J, Sambade C, Villanueva J, Varela Núñez R, Sobrinho Simoes M. Solid cell nests of the thyroid: light microscopy and immunohistochemical profile. Hum Pathol. 1994;25:684-93 pubmed
    ..study in this series provides further support to the belief that SCNs and "mixed thyroid follicles" represent remnants of the ultimobranchial body and should be considered normal components of the thyroid gland.
  6. Ozaki T, Nagashima K, Kusakabe T, Kakudo K, Kimura S. Development of thyroid gland and ultimobranchial body cyst is independent of p63. Lab Invest. 2011;91:138-46 pubmed publisher
    The ultimobranchial body (UBB) and thyroid primordium are the origins of the thyroid gland that fuse around embryonic day 14...
  7. Beckner M, Shultz J, Richardson T. Solid and cystic ultimobranchial body remnants in the thyroid. Arch Pathol Lab Med. 1990;114:1049-52 pubmed
    In this study we determined the incidence rate (89%) and characterized the morphology of ultimobranchial body (UBB) remnants found in 18 serially sectioned neonatal thyroid glands...
  8. Miura M, Kameda Y. Nicotinamide promotes long-term survival and extensive neurite outgrowth in ultimobranchial C cells cultured from chick embryos. J Comp Neurol. 2005;492:334-48 pubmed
    ..In conclusion, nicotinamide stimulates long-term survival and neuronal differentiation of chick embryo C cells, and this culture system may provide a useful model for studying neuronal differentiation mechanisms. ..
  9. Chojnowski J, Trau H, Masuda K, Manley N. Temporal and spatial requirements for Hoxa3 in mouse embryonic development. Dev Biol. 2016;415:33-45 pubmed publisher
    ..defects in the development of pharyngeal organs including athymia, aparathyroidism, thyroid hypoplasia, and ultimobranchial body persistence, in addition to defects of the throat cartilages and cranial nerves...

More Information

Publications82

  1. Kawa K. Voltage-gated sodium and potassium currents and their variation in calcitonin-secreting cells of the chick. J Physiol. 1988;399:93-113 pubmed
    ..These cells were presumed to represent non-secretory or supporting cells within the gland.(ABSTRACT TRUNCATED AT 400 WORDS) ..
  2. Johansson E, Andersson L, Örnros J, Carlsson T, Ingeson Carlsson C, Liang S, et al. Revising the embryonic origin of thyroid C cells in mice and humans. Development. 2015;142:3519-28 pubmed publisher
    ..In the ultimobranchial body epithelium emerging from pharyngeal pouch endoderm in early organogenesis, differential Foxa1/Foxa2 ..
  3. Alim A. Studies of the ultimobranchial gland of a teleost, Esomus danrica (Ham.). Folia Morphol (Praha). 1990;38:83-5 pubmed
    ..However, the sexual dimorphism of the ultimobranchial gland suggests that it also plays a role in reproduction, particularly in ovarian maturation. ..
  4. Nakamura T, Ichii O, Irie T, Mizoguchi T, Shinohara A, Kouguchi H, et al. Cotton rats (Sigmodon hispidus) possess pharyngeal pouch remnants originating from different primordia. Histol Histopathol. 2018;33:555-565 pubmed publisher
    ..These results indicated that the fossulae were a remnant of the ultimobranchial body in HIS/Hiph and of the thymopharyngeal duct in HIS/Mz...
  5. Gucer H, Mete O. Positivity for GATA3 and TTF-1 (SPT24), and Negativity for Monoclonal PAX8 Expand the Biomarker Profile of the Solid Cell Nests of the Thyroid Gland. Endocr Pathol. 2018;29:49-58 pubmed publisher
    ..H&E-stained sections; however, the morphological heterogeneity in SCNs and hyperplasia of these ultimobranchial body remnants can mimic other diagnostic entities including but not limited to papillary microcarcinoma...
  6. Srivastav A, Rani L, Sasayama Y. Influence of prolactin administration on the ultimobranchial body and parathyroid glands of the freshwater snake, Natrix piscator. Okajimas Folia Anat Jpn. 1994;71:59-66 pubmed
    The effects of ovine prolactin (10 I.U./100 g body wt) on the ultimobranchial body and parathyroid glands were investigated in Natrix piscator for 15 days...
  7. Barlet J, Gaumet N, Coxam V, Davicco M. [Calcitonin and stanniocalcin. Particular aspects of the endocrine regulation of phospho-calcium metabolism in mammals and fish]. Ann Endocrinol (Paris). 1998;59:281-90 pubmed
    ..and hypophosphatemic peptide calcitonin (CT) is secreted by mammalain thyroid parafollicular cells and fish ultimobranchial body. Over a dozen species of CTs have been cloned and/or sequenced...
  8. Nishiyama I, Fujii T. Laminin-induced process outgrowth from isolated fetal rat C-cells. Exp Cell Res. 1992;198:214-20 pubmed
    ..Thyroid-parathyroid-ultimobranchial body (UB) complexes from 16-day rat fetuses were treated with 0...
  9. Yoshidaterasawa K, Hayakawa D, Chen H, Emura S, Tamada A, Okumura T, et al. Fine structure of the parathyroid and ultimobranchial glands of the snake, Elaphe quadrivirgata. Okajimas Folia Anat Jpn. 1998;75:141-53 pubmed
    ..At the apical region the goblet cells had large granules of 300-1,200 nm in diameter. Ciliated cells projected cilia intermixed with micovilli from the apical surface of the cell into the follicular lumen. ..
  10. Sasayama Y, Takemura M, Takano K. Ultimobranchial glands in the teleost (Plecoglossus altivelis ryukyuensis): special references to changes of gland volume with maturation. Okajimas Folia Anat Jpn. 2001;78:101-6 pubmed
  11. Srivastav A, Tiwari P, Srivastav S, Suzuki N. Responses of the ultimobranchial gland to vitamin D3 treatment in freshwater mud eel, Amphipnous cuchia, kept in different calcium environments. Anat Histol Embryol. 2002;31:257-61 pubmed
    ..Also, the ultimobranchial glands became hyperactive following vitamin D3 treatment. It is concluded that in mud eels, the gland has a calcium-regulating function. ..
  12. Srbecka K, Michalova K, Curcikova R, Michal M, Dubova M, Svajdler M, et al. Spectrum of lesions derived from branchial arches occurring in the thyroid: from solid cell nests to tumors. Virchows Arch. 2017;471:393-400 pubmed publisher
    ..In the thyroid, the main source of various structures which may cause diagnostic dilemma is the ultimobranchial body. To investigate the spectrum of such thyroid lesions, the consultation files were reviewed for thyroid ..
  13. Kameda Y. Occurrence of calcitonin-positive C cells within the distal vagal ganglion and the recurrent laryngeal nerve of the chicken. Anat Rec. 1989;224:43-54 pubmed
    ..In addition, C cells were partly covered with the long cytoplasmic processes of Schwann cells and were also in contact with the Schwann cell perikarya. The C cells in nerves appear to be controlled by neural stimulation. ..
  14. Vázquez Román V, Utrilla J, Fernández Santos J, Conde E, Bernabé R, Sampedro C, et al. Postnatal fate of the ultimobranchial remnants in the rat thyroid gland. J Morphol. 2013;274:725-32 pubmed publisher
    The ultimobranchial follicles (UBFs) are considered embryonic remnants from the ultimobranchial body (UBB). They are follicular structures that vary in size and appearance depending on the age of the rat...
  15. Kaida N, Sasayama Y. Dynamics of plasma Ca and calcitonin levels in stonefish (Inimicus japonicus) administered a high-Ca solution into the stomach. Zoolog Sci. 2003;20:353-6 pubmed
  16. Kameda Y, Hirota C, Murakami M. Immuno-electron-microscopic localization of enkephalin in the secretory granules of C cells in the chicken ultimobranchial glands. Cell Tissue Res. 1993;274:257-65 pubmed
    ..Enkephalin-immunoreactive nerve fibers were characterized by the presence of granular vesicles, 60-160 nm in diameter, and frequently established direct contact with the surface of C cells.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  17. Sawicki B, Zabel M. Immunocytochemical study of parafollicular cells of the thyroid and ultimobranchial remnants of the European bison. Acta Histochem. 1997;99:223-30 pubmed
  18. Pandey A. Endocrinology of calcium metabolism in amphibians, with emphasis on the evolution of hypercalcemic regulation in tetrapods. Biol Struct Morphog. 1992;4:102-26 pubmed
    ..This review deals exhaustively with the endocrinology of Ca metabolism in amphibians. Also, the evolution of hypercalcemic regulation in tetrapods will be discussed in the light of recent developments. ..
  19. Cordier A, Haumont S. Development of thymus, parathyroids, and ultimo-branchial bodies in NMRI and nude mice. Am J Anat. 1980;157:227-63 pubmed
  20. Harach H. Thyroglobulin in human thyroid follicles with acid mucin. J Pathol. 1991;164:261-3 pubmed
    ..These findings add further support to the belief that the ultimobranchial body is a source of at least some C cells and follicular cells, and support the view that thyroid mixed ..
  21. Sasayama Y, Oguro C, Ogasawara T, Hirano T, Harumi T, Wisessang S. The crab-eating frog Rana cancrivora: serum mineral concentrations and histology of the ultimobranchial gland and the parathyroid gland. Gen Comp Endocrinol. 1990;80:399-406 pubmed
    ..In the parathyroid gland, cells in the central part of the gland were smaller than those in the peripheral part...
  22. Yadav S, Srivastav A. Ultimobranchial and parathyroid glands of the pigeon Columba livia in response to 1,25OH2D3 administration. Microsc Res Tech. 2008;71:831-7 pubmed publisher
    ..After day 10 and day 15, there is a progressive decrease in the nuclear volume of parathyroidal cells and reduced chromaticity of nuclei has been noticed. Moreover, after 15 days few degenerating cells are observed...
  23. Yamamoto K, Suzuki N, Takahashi N, Sasayama Y, Kikuyama S. Estrogen receptors in the stingray (Dasyatis akajei) ultimobranchial gland. Gen Comp Endocrinol. 1996;101:107-14 pubmed
    ..Two positive signals were detected at 2.5 and 2.0 kb. Thus, the presence of ER was confirmed for the first time in nonmammalian calcitonin-secreting cells...
  24. Sasayama Y, Takei Y, Hasegawa S, Suzuki D. Direct raises in blood Ca levels by infusing a high-Ca solution into the blood stream accelerate the secretion of calcitonin from the ultimobranchial gland in eels. Zoolog Sci. 2002;19:1039-43 pubmed
    ..These results strongly suggest that, in eels, direct raises in blood Ca levels by infusion of a high-Ca solution via blood vessels can accelerate the secretion of calcitonin from the ultimobranchial gland...
  25. Homma T, Watanabe M, Hirose S, Kanai A, Kangawa K, Matsuo H. Isolation and determination of the amino acid sequence of chicken calcitonin I from chicken ultimobranchial glands. J Biochem. 1986;100:459-67 pubmed
    ..Chicken calcitonin I resembled the calcitonins from the ultimobranchial glands both of salmon and eel in sequence, biological activity, and immunological property...
  26. Sawicki B. [C-cells in the thyroid gland and in the remainder of the ultimobranchial body of bison]. Ann Anat. 1993;175:343-7 pubmed
    ..In the discussion, the meaning of paracrine has been described in autoregulatory mechanisms controlling the thyroid activity...
  27. Kameda Y, Kameya T, Frankfurter A. Immunohistochemical localization of a neuron-specific beta-tubulin isotype in the developing chicken ultimobranchial glands. Brain Res. 1993;628:121-7 pubmed
    ..In 10-day-old chickens, TuJ1 immunoreactivity was restricted to the nerve fibers...
  28. Yamada K, Sakai K, Yamada S. A morphological and immunohistochemical study of the ultimobranchial body in the Japanese lizard and the snake. Okajimas Folia Anat Jpn. 2001;78:161-8 pubmed
    A morphological and immunohistochemical study of the ultimobranchial body of reptiles Japanese lizard and snake was carried out...
  29. Haynes J. Parathyroids and ultimobranchial bodies in monotremes. Anat Rec. 1999;254:269-80 pubmed
    ..The gross anatomy and light microscopic structure of the ultimobranchial body, thymus, and thyroid are also given...
  30. Harmon B, Kelley L. Immunohistochemistry of ultimobranchial thyroid carcinomas in seven slaughtered cows and one bull. J Vet Diagn Invest. 2001;13:101-5 pubmed
  31. Kameda Y, Nishimaki T, Miura M, Jiang S, Guillemot F. Mash1 regulates the development of C cells in mouse thyroid glands. Dev Dyn. 2007;236:262-70 pubmed
    In mammals, the ultimobranchial body derived from the fourth pharyngeal pouch gives rise to thyroid C cells...
  32. Srivastav A, Das V, Srivastav S, Sasayama Y, Suzuki N. Morphological and functional aspects of reptilian ultimobranchial gland. Anat Histol Embryol. 1998;27:359-64 pubmed
    ..Other functions of calcitonin have also been suggested in reptiles for example in neurotransmission, in volume regulation, phosphate balance and promotion of bone calcification (at least in juveniles)...
  33. Miyauchi A, Matsuzuka F, Kuma K, Katayama S. Piriform sinus fistula and the ultimobranchial body. Histopathology. 1992;20:221-7 pubmed
    ..of the fistulae to major structures of the neck, strongly suggest that the fistulae are remnants related to the ultimobranchial body, and that the fistulae trace the migration route of the ultimobranchial body to the thyroid gland.
  34. Kameda Y. Evidence to support the distal vagal ganglion as the origin of C cells of the ultimobranchial gland in the chick. J Comp Neurol. 1995;359:1-14 pubmed
    ..e., C cells differentiate along the neuronal lineage. During embryonic development, C cells of the chick ultimobranchial glands transiently express a number of neuronal properties...
  35. Kameda Y. Immunohistochemical demonstration of keratins in the cysts of thyroid glands, parathyroid glands, and C-cell complexes of the dog. Am J Anat. 1987;180:87-99 pubmed
  36. Swarup K, Tewari N, Srivastav A. Ultimobranchial body and parathyroid gland of the parrot Psittacula psittacula in response to experimental hypercalcemia. Arch Anat Microsc Morphol Exp. 1986;75:271-7 pubmed
    ..From 20th day till the end of the experiment (30 days) these cells show feeble staining response. The parathyroid glands suffer from degenerative changes due to its inactivity under chronic hypercalcemia...
  37. Taylor A, Inpanbutr N, Deftos L. Localization of calbindin-D28K in calcitonin containing cells of chick ultimobranchial glands. Anat Rec. 1987;219:86-90 pubmed
  38. Srivastav A, Rani L. Ultimobranchial body and parathyroid gland of the frog, Rana tigrina in response to calcitonin administration. Biol Struct Morphog. 1989;2:136-40 pubmed
    ..25 MRC mU/g body wt) on the serum calcium and phosphate levels as well as on the activity of ultimobranchial body and parathyroid glands was investigated in the frog, Rana tigrina for 15 days...
  39. Martin V, Martin L, Viennet G, Hergel M, Carbillet J, Fellmann D. Ultrastructural features of "solid cell nest" of the human thyroid gland: a study of 8 cases. Ultrastruct Pathol. 2000;24:1-8 pubmed
  40. Yadav S, Srivastav A. Influence of calcitonin administration on ultimobranchial and parathyroid glands of pigeon, Columba livia. Microsc Res Tech. 2009;72:380-4 pubmed publisher
    ..Moreover, the gland exhibits more compactness on day 10 and day 15. Few degenerating cells are encountered after day 15 following calcitonin treatment...
  41. Yaoi Y, Suzuki M, Tomura H, Kurabuchi S, Sasayama Y, Tanaka S. Expression and localization of prohormone convertase PC1 in the calcitonin-producing cells of the bullfrog ultimobranchial gland. J Histochem Cytochem. 2003;51:1459-66 pubmed
    ..We conclude that the main prohormone convertase that is involved in the proteolytic cleavage of procalcitonin in the bullfrog is PC1...
  42. Honda J, Ogawa K, Taniguchi K. [Immunohistochemical and morphometric studies on the development of the thyroid, parathyroid and ultimobranchial body in Xenopus laevis Daudin]. Jikken Dobutsu. 1993;42:23-32 pubmed
    The development of the thyroid, parathyroid and ultimobranchial body was examined by immunohistochemistry and morphometric analysis in the larvae of Xenopus laevis Daudin from the time immediately after hatch to the end of metamorphosis...
  43. Ali S, Chan A, Leong S. Localization of nitrergic neuronal and non-neuronal cells in the ultimobranchial glands of the chicken. Anat Embryol (Berl). 1996;193:161-8 pubmed
    ..The distribution patterns of NADPH-d and NOS suggest that NO may play a role in the regulation of the secretory activity of and the blood flow through the ultimobranchial glands...
  44. Gevaerts H. Circannual rhythms in the activity of the parathyroid gland and ultimobranchial body cells of the frog Rana temporaria (Anura, Amphibia). Chronobiologia. 1991;18:21-30 pubmed
    The annual activity of the parathyroid gland cells and those of the ultimobranchial body cells of the frog Rana temporaria is quantitatively investigated by a morphometric study...
  45. Kameda Y, Okamoto K, Ito M, Tagawa T. Innervation of the C cells of chicken ultimobranchial glands studied by immunohistochemistry, fluorescence microscopy, and electron microscopy. Am J Anat. 1988;182:353-68 pubmed
    ..All of these features suggest that C-cell activity, i.e., secretion of hormones and catecholamines, may be regulated by nerve stimuli...
  46. Williams E, Toyn C, Harach H. The ultimobranchial gland and congenital thyroid abnormalities in man. J Pathol. 1989;159:135-41 pubmed
    ..This study has provided conclusive evidence that the ultimobranchial body contributes both C cells and follicular cells to the thyroid in man, has documented the prevalence of ..
  47. Kameda Y, Miura M, Ohno S. Expression and development of the proenkephalin mRNA in the C cells of chicken ultimobranchial glands. Brain Res. 2000;852:453-62 pubmed
    ..Thus, the present study evidences that proenkephalin mRNA is synthesized in almost all C cells of chicken ultimobranchial glands throughout life. Enkephalin may be essential for C cell function...
  48. Hidaka Y, Tanaka S, Suzuki M. Analysis of salmon calcitonin I in the ultimobranchial gland and gill filaments during development of rainbow trout, Oncorhynchus mykiss, by in situ hybridization and immunohistochemical staining. Zoolog Sci. 2004;21:629-37 pubmed
    ..The sCT-I mRNA was also expressed on the developing gill filaments, but immunoreactive sCT-I was not detected in these sites. These results provide basic data for further research on the organogenesis of the trout ultimobranchial gland...
  49. Inoue A, Komatsu Y, Ochiai J, Itagaki S, Nishide H, Shikano M, et al. Growth inhibition and morphological changes of LLC-PK1 induced by ultimobranchial calcitonins. Cell Biol Int Rep. 1990;14:887-96 pubmed
    ..These results indicate that the growth inhibition of LLC-PK1 by ultimobranchial CTs is mainly due to cellular death caused by the swelling of RER via a signalling pathway other than the cAMP-dependent event(s)...
  50. Srivastav A, Srivastava S, Mishra D, Srivastav S, Srivastav S. Ultimobranchial gland of freshwater catfish, Heteropneustes fossilis in response to deltamethrin treatment. Bull Environ Contam Toxicol. 2002;68:584-91 pubmed
  51. Conde E, Moreno A, Martin Lacave I, Fernandez A, Galera H. Immunocytochemical study of the ultimobranchial tubule in Wistar rats. Anat Histol Embryol. 1992;21:94-100 pubmed
    ..repeated existence of numerous mitosis and PAS (+) microfollicles, apparently rising from the UBT, support the hypothesis that the ultimobranchial body (UBB) may contribute partially to the formation of a part of the follicular component.
  52. Rai R, Mishra D, Srivastav S, Srivastav A. Ultimobranchial gland of a freshwater teleost, Heteropneustes fossilis, in response to cadmium treatment. Environ Toxicol. 2009;24:589-93 pubmed publisher
    ..Following 28 days cadmium exposure the nuclear volume exhibits a further decrease, and degeneration and vacuolization sets in...
  53. Chakrabarti P, Mukherjee D. Studies on the hypocalcemic actions of salmon calcitonin and ultimobranchial gland extracts in the freshwater teleost Cyprinus carpio. Gen Comp Endocrinol. 1993;90:267-73 pubmed
    ..In all the studies the protein-bound Ca2+ fraction remained unaffected. The observation thus indicate a potent hypocalcemic role of calcitonin or UBG in freshwater common carp under laboratory conditions...
  54. Geelhoed G. "Aging bull'. Med Hypotheses. 1996;47:471-9 pubmed
    ..Further, a number of the bulls who have the ultimobranchial tumors are found to have multiple endocrine tumors in other glands-bilateral pheochromocytomas and pituitary acidophil adenomas...
  55. Mishra D, Srivastav S, Srivastav A. Effects of the insecticide cypermethrin on plasma calcium and ultimobranchial gland of a teleost, Heteropneustes fossilis. Ecotoxicol Environ Saf. 2005;60:193-7 pubmed
    ..Following 28 days exposure, the nuclear volume undergoes further decrease and degeneration and vacuolization sets in...
  56. Maubras L, Cressent M, Minvielle S, Taboulet J, Jullienne A, Milhaud G, et al. Expression of the calcitonin gene during migration of the Pacific salmon, Oncorhynchus gorbuscha. Biochem Biophys Res Commun. 1990;173:788-94 pubmed
    ..In conclusion, sexual hormones still to be identified, are probably implicated in the expression of the calcitonin gene in females during the reproductive cycle...
  57. Merida Velasco J, Garcia Garcia J, Espin Ferra J, Linares J. Origin of the ultimobranchial body and its colonizing cells in human embryos. Acta Anat (Basel). 1989;136:325-30 pubmed
    The early development of the ultimobranchial body and its colonizing cells was studied in human embryos (O'Rahilly's stages 14 and 15)...
  58. Merida Velasco J, Espin Ferra J, Valdecasas R, Garcia Garcia J. Morphogenesis of the ultimobranchial body and its colonizing cells in the chick embryo. Arch Anat Histol Embryol. 1988;71:43-55 pubmed
    The development of the ultimobranchial body and its colonizing cells was studied in chick embryos in Hamburger-Hamilton's stages 21 to 46. The most significant observations included the following: 1...
  59. Kameda Y. Electron microscopic study on the development of the chicken ultimobranchial glands, with special reference to innervation of C cells. Anat Embryol (Berl). 1993;188:561-70 pubmed
    ..Some cells were still elongated or irregular in shape and contained small secretory granules, 60-200 nm in diameter...
  60. Carney J. Salivary heterotopia, cysts, and the parathyroid gland: branchial pouch derivatives and remnants. Am J Surg Pathol. 2000;24:837-45 pubmed
    ..One of the latter additionally had a focus of parathyroid cells in the cyst wall, and associated thyroid parenchyma with C cells, and cartilage...
  61. Yaoi Y, Suzuki M, Tomura H, Sasayama Y, Kikuyama S, Tanaka S. Molecular cloning of otoconin-22 complementary deoxyribonucleic acid in the bullfrog endolymphatic sac: effect of calcitonin on otoconin-22 messenger ribonucleic acid levels. Endocrinology. 2003;144:3287-96 pubmed
  62. Cameselle Teijeiro J, Abdulkader I, Soares P, Alfonsín Barreiro N, Moldes Boullosa J, Sobrinho Simoes M. Cystic tumor of the atrioventricular node of the heart appears to be the heart equivalent of the solid cell nests (ultimobranchial rests) of the thyroid. Am J Clin Pathol. 2005;123:369-75 pubmed
    ..The assumption that CTAVN is a ultimobranchial heterotopia fits with the known role of cardiac neural crest cells in cardiovascular development...
  63. Maddineni S, Krzysik Walker S, Ocón Grove O, Motch S, Hendricks G, Ramachandran R. Calcitonin is expressed in the chicken pituitary gland: influence of gonadal steroids and sexual maturation. Cell Tissue Res. 2007;327:521-8 pubmed
    ..We conclude that pituitary CT plays an important paracrine/autocrine role in the control of lactotroph function and PRL secretion in the chicken...
  64. Martial K, Maubras L, Taboulet J, Jullienne A, Milhaud G, Moukhtar M, et al. Production of salmon calcitonin I in Oncorhynchus gorbuscha by alternative polyadenylation of two RNA species. Gene. 1994;149:277-81 pubmed
    ..Moreover, it engenders a hypothesis of a relationship between the high concentration of the peptide observed in females of this species and their capacity to produce sCT by different biosynthetic pathways...
  65. Kuhn E, Malvi D. Images in pathology. Solid and cystic cell nests. Int J Surg Pathol. 2006;14:223 pubmed
  66. Srivastav A, Srivastava S, Mishra D, Srivastav S. Histological alterations in the ultimobranchial gland of teleost Heteropneustes fossilis in response to chlorpyrifos treatment. J Basic Clin Physiol Pharmacol. 2011;22:23-8 pubmed publisher
    ..Following 28 days treatment, the nuclear volume of these cells records a further decrease and the gland depicts vacuolization and degeneration at certain areas...
  67. Robertson D. Immunohistochemical and morphometric analysis of calcitonin distribution in anuran ultimobranchial glands. Gen Comp Endocrinol. 1988;71:349-58 pubmed
    ..462 mm2. This resulted in a 43% increase in the iCT(+) secretory area to 0.345 mm2. A model is proposed to explain the increase in iCT in the gland in response to a vitamin D and high calcium challenge...
  68. Kameda Y, Saitoh T, Nemoto N, Katoh T, Iseki S, Fujimura T. Hes1 is required for the development of pharyngeal organs and survival of neural crest-derived mesenchymal cells in pharyngeal arches. Cell Tissue Res. 2013;353:9-25 pubmed publisher
    ..Loss of Hes1 results in a spectrum of malformations of pharyngeal endoderm-derived organs, including the ultimobranchial body (progenitor of C cells), parathyroid, thymus and thyroid glands, together with highly penetrant C-cell ..
  69. Prasad M, Kumar A, Srivastav S, Srivastav A. Nerium indicum, a botanical pesticide affects ultimobranchial gland of the catfish Heteropneustes fossilis. Environ Toxicol. 2013;28:661-5 pubmed publisher
    ..Also there was noticed vacuolization and degeneration at certain places. To the best of our knowledge, the effects of any botanical pesticides on fish UBG have not been reported yet...
  70. Franz T. Persistent truncus arteriosus in the Splotch mutant mouse. Anat Embryol (Berl). 1989;180:457-64 pubmed
    ..The Splotch mutant mouse is proposed to be an animal model for persistent truncus arteriosus. The implications of the vascular malformations for the midgestational death of this mutant are discussed...
  71. Suzuki N, Yamamoto K, Sasayama Y, Suzuki T, Kurokawa T, Kambegawa A, et al. Possible direct induction by estrogen of calcitonin secretion from ultimobranchial cells in the goldfish. Gen Comp Endocrinol. 2004;138:121-7 pubmed
    ..This is the first report on the existence of ERs in a teleost UBG and the occurrence of CT secretion caused by estrogen...
  72. Fouchereau Peron M, Arlot Bonnemains Y, Maubras L, Milhaud G, Moukhtar M. Calcitonin variations in male and female trout, Salmo gairdneri, during the annual cycle. Gen Comp Endocrinol. 1990;78:159-63 pubmed
    Calcitonin (CT) levels in the ultimobranchial body and in plasma were radioimmunoassayed in rainbow trout, Salmo gairdneri, as a function of the annual cycle...
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