monkey diseases

Summary

Summary: Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).

Top Publications

  1. Parsons S, Gous T, Warren R, de Villiers C, Seier J, van Helden P. Detection of Mycobacterium tuberculosis infection in chacma baboons (Papio ursinus) using the QuantiFERON-TB gold (in-tube) assay. J Med Primatol. 2009;38:411-7 pubmed publisher
    ..Early diagnosis of simian tuberculosis (TB) is vital to prevent transmission of this disease. We evaluated the ability of the QuantiFERON-TB Gold (In-Tube Method) assay (QFG-IT) to detect TB in chacma baboons (Papio ursinus)...
  2. Spear G, Gilbert D, Sikaroodi M, Doyle L, Green L, Gillevet P, et al. Identification of rhesus macaque genital microbiota by 16S pyrosequencing shows similarities to human bacterial vaginosis: implications for use as an animal model for HIV vaginal infection. AIDS Res Hum Retroviruses. 2010;26:193-200 pubmed publisher
    ..These results also suggest macaques could be used as an animal model to study some aspects of bacterial vaginosis...
  3. Sintasath D, Wolfe N, LeBreton M, Jia H, Garcia A, Le Doux Diffo J, et al. Simian T-lymphotropic virus diversity among nonhuman primates, Cameroon. Emerg Infect Dis. 2009;15:175-84 pubmed
    ..Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations...
  4. Nakazawa S, Marchand R, Quang N, Culleton R, Manh N, Maeno Y. Anopheles dirus co-infection with human and monkey malaria parasites in Vietnam. Int J Parasitol. 2009;39:1533-7 pubmed publisher
    ..This study also shows that the preservation of mosquito salivary glands on filter paper, and the down-stream extraction of parasite DNA and RNA from those, offers a powerful resource for molecular epidemiological studies on malaria...
  5. David J, Dick E, Hubbard G. Spontaneous pathology of the common marmoset (Callithrix jacchus) and tamarins (Saguinus oedipus, Saguinus mystax). J Med Primatol. 2009;38:347-59 pubmed publisher
    ..Marmosets and tamarins are increasingly used in research, but their pathology remains poorly defined compared with Old World primates...
  6. Sun Z, Li A, Ye H, Shi Y, Hu Z, Zeng L. Natural infection with canine distemper virus in hand-feeding Rhesus monkeys in China. Vet Microbiol. 2010;141:374-8 pubmed publisher
    ..This is the first report we are aware of documenting Rhesus monkeys infected with CDV in China. Urgent work should be done to prevent the possibly epidemic of CDV in non-human primate...
  7. Banyai K, Esona M, Liu A, Wang Y, Tu X, Jiang B. Molecular detection of novel adenoviruses in fecal specimens of captive monkeys with diarrhea in China. Vet Microbiol. 2010;142:416-9 pubmed publisher
    ..A better understanding of the epidemiology of SAdVs and their potential role in gastroenteritis is critical to the implementation of advanced prevention strategies against AdV infection in captive primates...
  8. Leendertz S, Junglen S, Hedemann C, Goffe A, Calvignac S, Boesch C, et al. High prevalence, coinfection rate, and genetic diversity of retroviruses in wild red colobus monkeys (Piliocolobus badius badius) in Tai National Park, Cote d'Ivoire. J Virol. 2010;84:7427-36 pubmed publisher
    ..The high prevalence of all three retroviral infections in P. b. badius represents a source of infection to chimpanzees and possibly to humans, who hunt them...
  9. Gozalo A, Zerfas P, Starost M, Elkins W, Clarke C. Splenic angioleiomyoma in an owl monkey (Aotus nancymae). J Med Primatol. 2010;39:385-8 pubmed publisher
    ..Based on cell morphology, by light and TEM, and IHC a final diagnosis of splenic angioleiomyoma was made. This is, to our knowledge, the first report of an angioleiomyoma in a non-human primate. ..

More Information

Publications62

  1. Mouinga Ondeme A, Betsem E, Caron M, Makuwa M, Salle B, Renault N, et al. Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to humans. Retrovirology. 2010;7:105 pubmed publisher
    ..We evaluated the natural history of the virus in a free-ranging colony of mandrills and investigated possible transmission of mandrill SFV to humans...
  2. Knauf S, Batamuzi E, Mlengeya T, Kilewo M, Lejora I, Nordhoff M, et al. Treponema infection associated with genital ulceration in wild baboons. Vet Pathol. 2012;49:292-303 pubmed publisher
  3. Lee K, Divis P, Zakaria S, Matusop A, Julin R, Conway D, et al. Plasmodium knowlesi: reservoir hosts and tracking the emergence in humans and macaques. PLoS Pathog. 2011;7:e1002015 pubmed publisher
    ..However, ongoing ecological changes resulting from deforestation, with an associated increase in the human population, could enable this pathogenic species of Plasmodium to switch to humans as the preferred host...
  4. Chen E, Yagi S, Kelly K, Mendoza S, Tarara R, Canfield D, et al. Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony. PLoS Pathog. 2011;7:e1002155 pubmed publisher
    ..The discovery of TMAdV, a novel adenovirus with the capacity to infect both monkeys and humans, suggests that adenoviruses should be monitored closely as potential causes of cross-species outbreaks...
  5. Roy S, Sandhu A, Medina A, Clawson D, Wilson J. Adenoviruses in fecal samples from asymptomatic rhesus macaques, United States. Emerg Infect Dis. 2012;18:1081-8 pubmed publisher
    ..The high prevalence of adenoviruses in fecal samples from asymptomatic rhesus macaques and the similarity of the isolates to human strains indicates the possibility of animal-to-human transmission of SAdVs...
  6. Mbora D, McPeek M. Host density and human activities mediate increased parasite prevalence and richness in primates threatened by habitat loss and fragmentation. J Anim Ecol. 2009;78:210-8 pubmed publisher
    ..Colobus are arboreal folivores while mangabeys are terrestrial habitat generalists...
  7. Kunnath Velayudhan S, Davidow A, Wang H, Molina D, Huynh V, Salamon H, et al. Proteome-scale antibody responses and outcome of Mycobacterium tuberculosis infection in nonhuman primates and in tuberculosis patients. J Infect Dis. 2012;206:697-705 pubmed publisher
    ..We assessed correlations between infection outcome and antibody responses in macaques and humans by high-throughput, proteome-scale serological studies...
  8. Switzer W, Tang S, Ahuka Mundeke S, Shankar A, Hanson D, Zheng H, et al. Novel simian foamy virus infections from multiple monkey species in women from the Democratic Republic of Congo. Retrovirology. 2012;9:100 pubmed publisher
    ..Phylogenetic analysis was used to define the NHP species origin of SFV. Participants completed questionnaires to capture NHP exposure information...
  9. Bezjian M, Gillespie T, Chapman C, Greiner E. Coprologic evidence of gastrointestinal helminths of forest baboons, Papio anubis, in Kibale National Park, Uganda. J Wildl Dis. 2008;44:878-87 pubmed
    ..Strongyloides sp., and Trichostrongylus sp. The high prevalence of nematodes recovered in this study seems to support previous theories of high nematode infections in forested habits...
  10. Carrion R, Ro Y, Hoosien K, Ticer A, Brasky K, de la Garza M, et al. A small nonhuman primate model for filovirus-induced disease. Virology. 2011;420:117-24 pubmed publisher
    ..Lymphoid necrosis and lymphocytic depletion observed in spleen. These findings provide support for the use of the common marmoset as a small nonhuman primate model for filovirus induced hemorrhagic fever...
  11. Munene E, Otsyula M, Mbaabu D, Mutahi W, Muriuki S, Muchemi G. Helminth and protozoan gastrointestinal tract parasites in captive and wild-trapped African non-human primates. Vet Parasitol. 1998;78:195-201 pubmed
    ..Similar intervention against protozoa and other agents will not only improve primate health, but also increase safety to animal handlers and colony workers...
  12. Sestak K, Merritt C, Borda J, Saylor E, Schwamberger S, Cogswell F, et al. Infectious agent and immune response characteristics of chronic enterocolitis in captive rhesus macaques. Infect Immun. 2003;71:4079-86 pubmed
    ..The data also suggest that chronic colitis in rhesus macaques may have potential as a model of inflammatory bowel disease in humans...
  13. Ikegami T, Saijo M, Niikura M, Miranda M, Calaor A, Hernandez M, et al. Development of an immunofluorescence method for the detection of antibodies to Ebola virus subtype Reston by the use of recombinant nucleoprotein-expressing HeLa cells. Microbiol Immunol. 2002;46:633-8 pubmed
    ..These results suggest that this new IFA is useful for seroepidemiological studies of EBO-R infection among monkeys...
  14. Slattery J, Franchini G, Gessain A. Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses. Genome Res. 1999;9:525-40 pubmed
    ..Together, these patterns generate a model of HTLV/STLV emergence marked by an ancient ancestry, differential rates of divergence, and continued global expansion...
  15. Seethamchai S, Putaporntip C, Malaivijitnond S, Cui L, Jongwutiwes S. Malaria and Hepatocystis species in wild macaques, southern Thailand. Am J Trop Med Hyg. 2008;78:646-53 pubmed
    ..These findings indicate regional differences in malaria distribution among these macaques, as well as differences in potential risk of disease transmission to humans...
  16. McKenna P, Hoffmann C, Minkah N, Aye P, Lackner A, Liu Z, et al. The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis. PLoS Pathog. 2008;4:e20 pubmed publisher
    ..This work provides comprehensive data and improved methods for studying the role of commensal microbiota in macaque models of GI diseases and provides a model for the large-scale screening of the human gut microbiome...
  17. Jones Engel L, Engel G, Schillaci M, Lee B, Heidrich J, Chalise M, et al. Considering human-primate transmission of measles virus through the prism of risk analysis. Am J Primatol. 2006;68:868-79 pubmed
    ..Here the contrasting seroprevalences of the two sites are analyzed using risk analysis. These case studies show how risk analysis can be used to approach the phenomenon of cross-species pathogen transmission...
  18. Apetrei C, Lerche N, Pandrea I, Gormus B, Silvestri G, Kaur A, et al. Kuru experiments triggered the emergence of pathogenic SIVmac. AIDS. 2006;20:317-21 pubmed
  19. Mahieux R, Chappey C, Georges Courbot M, Dubreuil G, Mauclere P, Georges A, et al. Simian T-cell lymphotropic virus type 1 from Mandrillus sphinx as a simian counterpart of human T-cell lymphotropic virus type 1 subtype D. J Virol. 1998;72:10316-22 pubmed
    ..Due to the quasi-identity of both human and monkey viruses, interspecies transmission episodes leading to such a clade may have occurred recently...
  20. Engel G, Pizarro M, Shaw E, Cortes J, Fuentes A, Barry P, et al. Unique pattern of enzootic primate viruses in Gibraltar macaques. Emerg Infect Dis. 2008;14:1112-5 pubmed publisher
    ..All macaques were seronegative for herpesvirus B, simian T-cell lymphotropic virus, simian retrovirus, simian immunodeficiency virus, and rhesus cytomegalovirus. Seroprevalence of simian foamy virus reached 88% among adult animals...
  21. Newman R, Hall L, Kirmaier A, Pozzi L, Pery E, Farzan M, et al. Evolution of a TRIM5-CypA splice isoform in old world monkeys. PLoS Pathog. 2008;4:e1000003 pubmed publisher
    ..Whether the formation of novel genes through alternative splicing has played a wider role in the evolution of the TRIM family remains to be investigated...
  22. Schweizer M, Schleer H, Pietrek M, Liegibel J, Falcone V, Neumann Haefelin D. Genetic stability of foamy viruses: long-term study in an African green monkey population. J Virol. 1999;73:9256-65 pubmed
    ..5 to 100%), and only a minimal genetic drift was recognized within the series of isolates. In conclusion, the low in vivo divergency of FV SU suggests that genetic variability is not important for the maintenance of FV persistence...
  23. Nerrienet E, Meertens L, Kfutwah A, Foupouapouognigni Y, Gessain A. Molecular epidemiology of simian T-lymphotropic virus (STLV) in wild-caught monkeys and apes from Cameroon: a new STLV-1, related to human T-lymphotropic virus subtype F, in a Cercocebus agilis. J Gen Virol. 2001;82:2973-7 pubmed
  24. Ikegami T, Saijo M, Niikura M, Miranda M, Calaor A, Hernandez M, et al. Immunoglobulin G enzyme-linked immunosorbent assay using truncated nucleoproteins of Reston Ebola virus. Epidemiol Infect. 2003;130:533-9 pubmed
    ..The results indicate that this IgG ELISA is useful for detecting EBO-R specific antibody, and may have a potential to discriminate EBO-R infection from other subtypes...
  25. Gabet A, Gessain A, Wattel E. High simian T-cell leukemia virus type 1 proviral loads combined with genetic stability as a result of cell-associated provirus replication in naturally infected, asymptomatic monkeys. Int J Cancer. 2003;107:74-83 pubmed
  26. Courgnaud V, Van Dooren S, Liegeois F, Pourrut X, Abela B, Loul S, et al. Simian T-cell leukemia virus (STLV) infection in wild primate populations in Cameroon: evidence for dual STLV type 1 and type 3 infection in agile mangabeys (Cercocebus agilis). J Virol. 2004;78:4700-9 pubmed
  27. Chapman C, Speirs M, Gillespie T, Holland T, Austad K. Life on the edge: gastrointestinal parasites from the forest edge and interior primate groups. Am J Primatol. 2006;68:397-409 pubmed
  28. Kaur A, Yang J, Hempel D, Gritz L, Mazzara G, McClure H, et al. Identification of multiple simian immunodeficiency virus (SIV)-specific CTL epitopes in sooty mangabeys with natural and experimentally acquired SIV infection. J Immunol. 2000;164:934-43 pubmed
    ..Longitudinal studies of viral load and sequence variation in CTL epitopes may provide useful information on the role of CTL in control or persistence of SIV infection in sooty mangabeys...
  29. Ikegami T, Miranda M, Calaor A, Manalo D, Miranda N, Niikura M, et al. Histopathology of natural Ebola virus subtype Reston infection in cynomolgus macaques during the Philippine outbreak in 1996. Exp Anim. 2002;51:447-55 pubmed
    ..These results indicate that EBO-R infection is characterized by systemic coagulopathy and an increase in blood-derived macrophages/monocytes in accordance with the EBO-R propagation in macrophages/monocytes...
  30. Huff J, Eberle R, Capitanio J, Zhou S, Barry P. Differential detection of B virus and rhesus cytomegalovirus in rhesus macaques. J Gen Virol. 2003;84:83-92 pubmed
    ..Detection of B virus DNA shedding is a relatively rare event associated with the breeding season, while RhCMV DNA is persistently detected in mucosal fluids of most monkeys...
  31. Meertens L, Shanmugam V, Gessain A, Beer B, Tooze Z, Heneine W, et al. A novel, divergent simian T-cell lymphotropic virus type 3 in a wild-caught red-capped mangabey (Cercocebus torquatus torquatus) from Nigeria. J Gen Virol. 2003;84:2723-7 pubmed
  32. Garcia M, Bouley D, Larson M, Lifland B, Moorhead R, Simkins M, et al. Outbreak of Mycobacterium bovis in a conditioned colony of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques. Comp Med. 2004;54:578-84 pubmed
  33. Schillaci M, Jones Engel L, Engel G, Paramastri Y, Iskandar E, Wilson B, et al. Prevalence of enzootic simian viruses among urban performance monkeys in Indonesia. Trop Med Int Health. 2005;10:1305-14 pubmed
    ..No evidence of infection with simian immunodeficiency virus was detected in these macaques. These results suggest that urban performance monkeys are a reservoir for enzootic simian viruses known to be capable of infecting humans...
  34. Calattini S, Wanert F, Thierry B, Schmitt C, Bassot S, Saib A, et al. Modes of transmission and genetic diversity of foamy viruses in a Macaca tonkeana colony. Retrovirology. 2006;3:23 pubmed
  35. Makuwa M, Souquiere S, Clifford S, Telfer P, Salle B, Bourry O, et al. Two distinct STLV-1 subtypes infecting Mandrillus sphinx follow the geographic distribution of their hosts. AIDS Res Hum Retroviruses. 2004;20:1137-43 pubmed
    ..The clustering of these new STLV-1mnd sequences with HTLV-1 subtype D and F suggests first, past simian-to-human transmissions in Central Africa and second, that species barriers are easier to cross over than geographic barriers...
  36. Bukh J, Apgar C, Govindarajan S, Purcell R. Host range studies of GB virus-B hepatitis agent, the closest relative of hepatitis C virus, in New World monkeys and chimpanzees. J Med Virol. 2001;65:694-7 pubmed
    ..Finally, we failed to detect GBV-B in acute-phase serum from surgeon GB. Our data suggest that GBV-B is not a human virus and that GBV-B, like GBV-A, is a virus of New World monkeys...
  37. Favoretto S, de Mattos C, Morais N, Alves Araújo F, De Mattos C. Rabies in marmosets (Callithrix jacchus), Ceará, Brazil. Emerg Infect Dis. 2001;7:1062-5 pubmed
    ..The marmoset, Callithrix jacchus acchus, was determined to be the source of exposure...
  38. Kenny D, Knightly F, Baier J, Moore S, Gordon C, Davis R, et al. Exposure of hooded capuchin monkeys (Cebus apella cay) to a rabid bat at a zoological park. J Zoo Wildl Med. 2001;32:123-6 pubmed
    ..Although a serologic titer of 0.05 IU/ml indicates an adequate human response after rabies vaccination, no similar information is available for nonhuman primates. To date, none of the monkeys has succumbed to rabies...
  39. Passos E, Germano P, Guimaraes M, Fedullo J, Correa S, Consales C, et al. Inactivated suckling mouse brain rabies vaccine provides short-term immunity in capuchin monkeys (Cebus apella). J Zoo Wildl Med. 2001;32:55-7 pubmed
    ..5 IU/ml after vaccination, but the immune response persisted for only 122.3 +/- 32.6 days. The SMBV was able to induce immune response in the capuchin monkeys, but protection was short-lived...
  40. Hussain A, Shanmugam V, Bhullar V, Beer B, Vallet D, Gautier Hion A, et al. Screening for simian foamy virus infection by using a combined antigen Western blot assay: evidence for a wide distribution among Old World primates and identification of four new divergent viruses. Virology. 2003;309:248-57 pubmed
    ..These results demonstrate the ability of the CA-WB assay to detect infection in a large number of NHP species, including previously uncharacterized infections with divergent SFVs...
  41. Huff J, Barry P. B-virus (Cercopithecine herpesvirus 1) infection in humans and macaques: potential for zoonotic disease. Emerg Infect Dis. 2003;9:246-50 pubmed
    ..Knowledge of the clinical signs and risk factors for human B-virus disease allows early initiation of antiviral therapy and prevents severe disease or death...
  42. Engel G, Hungerford L, Jones Engel L, Travis D, Eberle R, Fuentes A, et al. Risk assessment: A model for predicting cross-species transmission of simian foamy virus from macaques (M. fascicularis) to humans at a monkey temple in Bali, Indonesia. Am J Primatol. 2006;68:934-48 pubmed
    ..This model sets the stage for a discussion about modeling as a risk assessment tool and the kinds of data that are required to accurately predict transmission...
  43. Richards A, Giri A, Iskandriati D, Pamungkas J, Sie A, Rosen L, et al. Simian T-lymphotropic virus type I infection among wild-caught Indonesian pig-tailed macaques (Macaca nemestrina). J Acquir Immune Defic Syndr Hum Retrovirol. 1998;19:542-5 pubmed
    ..Phylogenic analyses of tax gene fragment sequences from the PCR products of two samples, 930287 and 930306, indicated that these animals were infected with retroviruses related to those of the Asian STLV-I clade...
  44. Rollin P, Williams R, Bressler D, Pearson S, Cottingham M, Pucak G, et al. Ebola (subtype Reston) virus among quarantined nonhuman primates recently imported from the Philippines to the United States. J Infect Dis. 1999;179 Suppl 1:S108-14 pubmed
  45. Fortune B, Wang L, Bui B, Burgoyne C, Cioffi G. Idiopathic bilateral optic atrophy in the rhesus macaque. Invest Ophthalmol Vis Sci. 2005;46:3943-56 pubmed
    ..To document the existence of idiopathic bilateral optic atrophy (BOA) in rhesus macaque monkeys and to characterize the structural and functional consequences of this condition...
  46. Vilchez R. Viruses from nonhuman primates. Emerg Infect Dis. 2006;12:1802-3; author reply 1803 pubmed
  47. Brennan G, Kozyrev Y, Kodama T, Hu S. Novel TRIM5 isoforms expressed by Macaca nemestrina. J Virol. 2007;81:12210-7 pubmed publisher
    ..The expression of TRIM5 alleles incapable of restricting HIV-1 infection may contribute to the previously reported increased susceptibility of M. nemestrina to HIV-1 infection in vivo...
  48. Mohan M, Aye P, Borda J, Alvarez X, Lackner A. Gastrointestinal disease in simian immunodeficiency virus-infected rhesus macaques is characterized by proinflammatory dysregulation of the interleukin-6-Janus kinase/signal transducer and activator of transcription3 pathway. Am J Pathol. 2007;171:1952-65 pubmed
    ..Despite high SOCS-3 expression, STAT3 remained constitutively active, providing a possible explanation for persistent intestinal inflammation and immune activation that may favor viral replication and disease pro-gression...
  49. Bielefeldt Ohmann H, Barouch D, Bakke A, Bruce A, Durning M, Grant R, et al. Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta). Vet Pathol. 2005;42:391-6 pubmed
    ..Collectively, these findings suggest a relation to but not absolute identity with simian mesenchymoproliferative disorders (MPD) or typical gastrointestinal stromal tumors (GISTs)...
  50. Yue Y, Zhou S, Barry P. Antibody responses to rhesus cytomegalovirus glycoprotein B in naturally infected rhesus macaques. J Gen Virol. 2003;84:3371-9 pubmed
    ..Thus, the rhesus macaque model of HCMV infection is relevant for testing gB-based immune therapies...
  51. Ling B, Apetrei C, Pandrea I, Veazey R, Lackner A, Gormus B, et al. Classic AIDS in a sooty mangabey after an 18-year natural infection. J Virol. 2004;78:8902-8 pubmed
    ..Therefore, the results also suggest that SMs have a special mechanism for resisting AIDS development...
  52. Leroy E, Telfer P, Kumulungui B, Yaba P, Rouquet P, Roques P, et al. A serological survey of Ebola virus infection in central African nonhuman primates. J Infect Dis. 2004;190:1895-9 pubmed
    ..They also suggest that future Ebola outbreaks may occur anywhere in the central African forest region...
  53. Ng O, Ooi E, Lee C, Lee P, Ng L, Pei S, et al. Naturally acquired human Plasmodium knowlesi infection, Singapore. Emerg Infect Dis. 2008;14:814-6 pubmed publisher
    ..In industrialized countries, free-ranging primates are a potential source of P. knowlesi human infection. P. knowlesi infection is a differential diagnosis of febrile illness acquired in Singapore...