ape diseases

Summary

Summary: Diseases of chimpanzees, gorillas, and orangutans.

Top Publications

  1. Klee S, Ozel M, Appel B, Boesch C, Ellerbrok H, Jacob D, et al. Characterization of Bacillus anthracis-like bacteria isolated from wild great apes from Cote d'Ivoire and Cameroon. J Bacteriol. 2006;188:5333-44 pubmed
    ..We propose that the newly discovered atypical B. anthracis strains share a common ancestor with classic B. anthracis or that they emerged recently by transfer of the B. anthracis plasmids to a strain of the B. cereus group...
  2. Leroy E, Rouquet P, Formenty P, Souquiere S, Kilbourne A, Froment J, et al. Multiple Ebola virus transmission events and rapid decline of central African wildlife. Science. 2004;303:387-90 pubmed
    ..Surveillance of animal mortality may help to predict and prevent human Ebola outbreaks...
  3. Singh B, Simon Divis P. Orangutans not infected with Plasmodium vivax or P. cynomolgi, Indonesia. Emerg Infect Dis. 2009;15:1657-8 pubmed publisher
    ..We found that these orangutans are not hosts of P. cynomolgi and P. vivax. Analysis of >or=1 genes is needed to identify Plasmodium spp. infecting orangutans...
  4. Hussain A, Shanmugam V, Bhullar V, Beer B, Vallet D, Gautier Hion A, et al. Screening for simian foamy virus infection by using a combined antigen Western blot assay: evidence for a wide distribution among Old World primates and identification of four new divergent viruses. Virology. 2003;309:248-57 pubmed
    ..These results demonstrate the ability of the CA-WB assay to detect infection in a large number of NHP species, including previously uncharacterized infections with divergent SFVs...
  5. Formenty P, Boesch C, Wyers M, Steiner C, Donati F, Dind F, et al. Ebola virus outbreak among wild chimpanzees living in a rain forest of Côte d'Ivoire. J Infect Dis. 1999;179 Suppl 1:S120-6 pubmed
    ..A high mortality rate among apes tends to indicate that they are not the reservoir for the disease causing the illness. These points will have to be investigated by additional studies...
  6. Keele B, Van Heuverswyn F, Li Y, Bailes E, Takehisa J, Santiago M, et al. Chimpanzee reservoirs of pandemic and nonpandemic HIV-1. Science. 2006;313:523-6 pubmed
    ..These findings establish P. t. troglodytes as a natural reservoir of HIV-1...
  7. Köndgen S, Kühl H, N Goran P, Walsh P, Schenk S, Ernst N, et al. Pandemic human viruses cause decline of endangered great apes. Curr Biol. 2008;18:260-4 pubmed publisher
    ..These observations illustrate the challenge of maximizing the benefit of research and tourism to great apes while minimizing the negative side effects...
  8. Liu W, Worobey M, Li Y, Keele B, Bibollet Ruche F, Guo Y, et al. Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees. PLoS Pathog. 2008;4:e1000097 pubmed publisher
  9. Bailes E, Gao F, Bibollet Ruche F, Courgnaud V, Peeters M, Marx P, et al. Hybrid origin of SIV in chimpanzees. Science. 2003;300:1713 pubmed

More Information

Publications62

  1. Duval L, Nerrienet E, Rousset D, Sadeuh Mba S, Houze S, Fourment M, et al. Chimpanzee malaria parasites related to Plasmodium ovale in Africa. PLoS ONE. 2009;4:e5520 pubmed publisher
    ..ovale strains isolated from humans. This study provides the first evidence of possibility of natural cross-species exchange of P. ovale between humans and chimpanzees of the subspecies Pan t. troglodytes. ..
  2. Santiago M, Rodenburg C, Kamenya S, Bibollet Ruche F, Gao F, Bailes E, et al. SIVcpz in wild chimpanzees. Science. 2002;295:465 pubmed
  3. Hayakawa T, Arisue N, Udono T, Hirai H, Sattabongkot J, Toyama T, et al. Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees. PLoS ONE. 2009;4:e7412 pubmed publisher
    ..malariae infection in humans. To our knowledge, this is the first to report P. malariae infection in chimpanzees and a human malaria parasite from nonhuman primates imported to a nonendemic country...
  4. Szentiks C, Köndgen S, Silinski S, Speck S, Leendertz F. Lethal pneumonia in a captive juvenile chimpanzee (Pan troglodytes) due to human-transmitted human respiratory syncytial virus (HRSV) and infection with Streptococcus pneumoniae. J Med Primatol. 2009;38:236-40 pubmed publisher
    ..One infant female chimpanzee with severe respiratory symptoms died despite immediate medical treatment and was submitted for necropsy...
  5. Jones Engel L, May C, Engel G, Steinkraus K, Schillaci M, Fuentes A, et al. Diverse contexts of zoonotic transmission of simian foamy viruses in Asia. Emerg Infect Dis. 2008;14:1200-8 pubmed publisher
    ..Thus, SFV infections are likely to be prevalent among persons who live or work near nonhuman primates in Asia...
  6. Liu W, Li Y, Learn G, Rudicell R, Robertson J, Keele B, et al. Origin of the human malaria parasite Plasmodium falciparum in gorillas. Nature. 2010;467:420-5 pubmed publisher
    ..falciparum formed a monophyletic lineage within the gorilla parasite radiation. These findings indicate that P. falciparum is of gorilla origin and not of chimpanzee, bonobo or ancient human origin...
  7. Kaiser M, Löwa A, Ulrich M, Ellerbrok H, Goffe A, Blasse A, et al. Wild chimpanzees infected with 5 Plasmodium species. Emerg Infect Dis. 2010;16:1956-9 pubmed publisher
    ..We surveyed Plasmodium spp. diversity in wild chimpanzees living in an undisturbed tropical rainforest habitat and found 5 species: P. malariae, P. vivax, P. ovale, P. reichenowi, and P. gaboni...
  8. Reid M, Ursic R, Cooper D, Nazzari H, Griffiths M, Galdikas B, et al. Transmission of human and macaque Plasmodium spp. to ex-captive orangutans in Kalimantan, Indonesia. Emerg Infect Dis. 2006;12:1902-8 pubmed
    ..These data have potential implications for the conservation of orangutans and also for the bidirectional transmission of parasites between orangutans and humans visiting or living in the region...
  9. Calattini S, Nerrienet E, Mauclere P, Georges Courbot M, Saib A, Gessain A. Detection and molecular characterization of foamy viruses in Central African chimpanzees of the Pan troglodytes troglodytes and Pan troglodytes vellerosus subspecies. J Med Primatol. 2006;35:59-66 pubmed
    ..This zoonotic infection was demonstrated mainly after bites by chimpanzees [Pan troglodytes (P. t.)] of the West African P. t. verus subspecies in primatology centers or zoos in the USA...
  10. Leroy E, Kumulungui B, Pourrut X, Rouquet P, Hassanin A, Yaba P, et al. Fruit bats as reservoirs of Ebola virus. Nature. 2005;438:575-6 pubmed
    ..We find evidence of asymptomatic infection by Ebola virus in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus...
  11. Switzer W, Parekh B, Shanmugam V, Bhullar V, Phillips S, Ely J, et al. The epidemiology of simian immunodeficiency virus infection in a large number of wild- and captive-born chimpanzees: evidence for a recent introduction following chimpanzee divergence. AIDS Res Hum Retroviruses. 2005;21:335-42 pubmed
    ..The absence of SIVcpz infection in P. t. verus suggests that SIVcpz may not be endemic to this subspecies and implies that SIVcpz may have been introduced more recently into the chimpanzee subspecies following divergence...
  12. Gao F, Bailes E, Robertson D, Chen Y, Rodenburg C, Michael S, et al. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature. 1999;397:436-41 pubmed
    ..t. troglodytes is the primary reservoir for HIV-1 and has been the source of at least three independent introductions of SIVcpz into the human population...
  13. Calattini S, Nerrienet E, Mauclere P, Georges Courbot M, Saib A, Gessain A. Natural simian foamy virus infection in wild-caught gorillas, mandrills and drills from Cameroon and Gabon. J Gen Virol. 2004;85:3313-7 pubmed
  14. Walsh P, Abernethy K, Bermejo M, Beyers R, De Wachter P, Akou M, et al. Catastrophic ape decline in western equatorial Africa. Nature. 2003;422:611-4 pubmed
    ..Without aggressive investments in law enforcement, protected area management and Ebola prevention, the next decade will see our closest relatives pushed to the brink of extinction...
  15. Nerrienet E, Meertens L, Kfutwah A, Foupouapouognigni Y, Gessain A. Molecular epidemiology of simian T-lymphotropic virus (STLV) in wild-caught monkeys and apes from Cameroon: a new STLV-1, related to human T-lymphotropic virus subtype F, in a Cercocebus agilis. J Gen Virol. 2001;82:2973-7 pubmed
  16. Switzer W, Bhullar V, Shanmugam V, Cong M, Parekh B, Lerche N, et al. Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates. J Virol. 2004;78:2780-9 pubmed
    ..Our data highlight the importance of studies to better define the public health implications of zoonotic SFV infections...
  17. Jensen S, Mundry R, Nunn C, Boesch C, Leendertz F. Non-invasive body temperature measurement of wild chimpanzees using fecal temperature decline. J Wildl Dis. 2009;45:542-6 pubmed
    ..The method was successfully applied and the average estimated temperature of the chimpanzees was 37.2 C. This simple-to-use field method reliably estimates the body temperature of wild chimpanzees and probably also other large mammals...
  18. Kaur T, Singh J, Tong S, Humphrey C, Clevenger D, Tan W, et al. Descriptive epidemiology of fatal respiratory outbreaks and detection of a human-related metapneumovirus in wild chimpanzees (Pan troglodytes) at Mahale Mountains National Park, Western Tanzania. Am J Primatol. 2008;70:755-65 pubmed publisher
    ..In addition, descriptive epidemiology should be a major component of disease outbreak investigations...
  19. Köndgen S, Schenk S, Pauli G, Boesch C, Leendertz F. Noninvasive monitoring of respiratory viruses in wild chimpanzees. Ecohealth. 2010;7:332-41 pubmed publisher
    ..The methods presented here may also be applied for the investigation of further acute diseases in great apes and other species...
  20. Hubbard G, Lee D, Steele K, Lee S, Binhazim A, Brasky K. Spontaneous amyloidosis in twelve chimpanzees, Pan troglodytes. J Med Primatol. 2001;30:260-7 pubmed
    ..Amyloid was deposited primarily in the liver. Amyloidosis in the chimpanzee is a chronic, intractable, progressive, fatal disease, and appears to be similar to secondary amy loidosis in other species...
  21. Walsh P. A rant on infectious disease and ape research priorities. Am J Primatol. 2008;70:719-21 pubmed publisher
  22. Jones P, Mahamba C, Rest J, André C. Fatal inflammatory heart disease in a bonobo (Pan paniscus). J Med Primatol. 2005;34:45-9 pubmed
    ..Findings included acute on chronic heart failure combined with the unusual but characteristic histopathological features of non-suppurative necrotizing myocarditis with mononuclear, inflammatory infiltration of the brain...
  23. Graczyk T, Mudakikwa A, Cranfield M, Eilenberger U. Hyperkeratotic mange caused by Sarcoptes scabiei (Acariformes: Sarcoptidae) in juvenile human-habituated mountain gorillas (Gorilla gorilla beringei). Parasitol Res. 2001;87:1024-8 pubmed
  24. Allender M, McCain S, Ramsay E, Schumacher J, Ilha M. Cervical necrotizing fasciitis and myositis in a western lowland gorilla (Gorilla gorilla gorilla). J Med Primatol. 2009;38:156-9 pubmed publisher
    ..Alpha-hemolytic Streptococcus and Prevotella sp. were isolated from the cervical lesion. This is a report of cervical necrotizing fasciitis in a western lowland gorilla...
  25. Mätz Rensing K, Kunze M, Zöller M, Roos C, Kiderlen A, Ludwig C, et al. Fatal Balamuthia mandrillaris infection in a gorilla - first case of balamuthiasis in Germany. J Med Primatol. 2011;40:437-40 pubmed publisher
    ..A 12-year-old female western lowland gorilla died in a zoological garden in Germany after exhibiting general neurological signs...
  26. Kato T, Choi Y, Elmowalid G, Sapp R, Barth H, Furusaka A, et al. Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation. Hepatology. 2008;48:732-40 pubmed publisher
    ..A common mutation G838R in the NS2 region emerged early in both chimpanzees. This mutation enhances viral assembly, leading to an increase in viral production in transfected or infected cells...
  27. Betsem E, Rua R, Tortevoye P, Froment A, Gessain A. Frequent and recent human acquisition of simian foamy viruses through apes' bites in central Africa. PLoS Pathog. 2011;7:e1002306 pubmed publisher
    ..The virus was found to persist over several years, with low SFV loads in infected persons. Secondary transmission remains an open question...
  28. Rehmann P, Grone A, Lawrenz A, Pagan O, Gottstein B, Bacciarini L. Echinococcus multilocularis in two lowland gorillas (Gorilla g. gorilla). J Comp Pathol. 2003;129:85-8 pubmed
    ..multilocularis was diagnosed. The pathological changes in alveolar echinococcosis in gorillas appear to resemble more closely those found in human beings than those in other non-human primates...
  29. Nunamaker E, Lee D, Lammey M. Chronic diseases in captive geriatric female Chimpanzees (Pan troglodytes). Comp Med. 2012;62:131-6 pubmed
    ..75%) and renal disease (31.25%). These data show the incidence of disease in geriatric female chimpanzees and predict likely medical management challenges associated with maintaining an aging chimpanzee population...
  30. Lankester F, Mätz Rensing K, Kiyang J, Jensen S, Weiss S, Leendertz F. Fatal ulcerative colitis in a western lowland gorilla (Gorilla gorilla gorilla). J Med Primatol. 2008;37:297-302 pubmed publisher
    ..Despite successful treatment of the bacterial infection the secondary deep invasion of B. coli was not reversed, possibly because of the failure of the treatment regimen, and led to the death of the gorilla...
  31. Muehlenbein M. Intestinal parasite infections and fecal steroid levels in wild chimpanzees. Am J Phys Anthropol. 2006;130:546-50 pubmed
    ..The utility of fecal samples for assessing immune-endocrine interactions is discussed...
  32. Zielonka A, Verschoor E, Gedvilaite A, Roesler U, Muller H, Johne R. Detection of chimpanzee polyomavirus-specific antibodies in captive and wild-caught chimpanzees using yeast-expressed virus-like particles. Virus Res. 2011;155:514-9 pubmed publisher
    ..7% positive results, ranging from 0% to 56% in different groups. The VLPs may be used in future to assess the distribution of ChPyV infections among other animal species and humans...
  33. Rothschild B, Rühli F. Comparison of arthritis characteristics in lowland Gorilla gorilla and mountain Gorilla beringei. Am J Primatol. 2005;66:205-18 pubmed
    ..gorilla and G. beringei. However, the different patterns of peripheral joint involvement suggest a causality resulting from lifestyle (e.g., the presence/absence or extent of knuckle walking) or a habitat-related infectious agent...
  34. Miyabe Nishiwaki T, Kaneko A, Nishiwaki K, Watanabe A, Watanabe S, Maeda N, et al. Tetraparesis resembling acute transverse myelitis in a captive chimpanzee (Pan troglodytes): long-term care and recovery. J Med Primatol. 2010;39:336-46 pubmed publisher
    ..Magnetic resonance imaging showed a diffuse T2-weighted hyperintensive lesion, indicating inflammation at the C1-2 level. All infective, autoimmune, and vascular investigations were unremarkable...
  35. Groenewoud M, Fagrouch Z, van Gessel S, Niphuis H, Bulavaite A, Warren K, et al. Characterization of novel polyomaviruses from Bornean and Sumatran orang-utans. J Gen Virol. 2010;91:653-8 pubmed publisher
    ..Neighbour-joining analysis positioned the viruses in a large cluster together with viruses from bats, bovines, rodents and several primate PyVs from chimpanzees, African green monkeys, squirrel monkeys and the human Merkel cell PyV...
  36. Wolfla C, Puckett T. Reversal of neurologic deficit in an adult gorilla with severe symptomatic lumbar stenosis. Spine (Phila Pa 1976). 2004;29:E95-7 pubmed
    ..A case report is presented...
  37. White N. Sharing malarias. Lancet. 2004;363:1006 pubmed
  38. Kaur T, Singh J, Lindsay D. Prevalence of Troglodytella abrassarti Brumpt and Joyeux, 1912 in wild chimpanzees (Pan troglodytes schweinfurthii) at Mahale Mountains National Park in Western Tanzania. J Parasitol. 2010;96:209-10 pubmed publisher
    ..abrassarti. The high prevalence of T. abrassarti in these chimpanzees is consistent with previous reports of this organism in chimpanzees...
  39. Watanabe H, Wells F, Major M. Clearance of hepatitis C in chimpanzees is associated with intrahepatic T-cell perforin expression during the late acute phase. J Viral Hepat. 2010;17:245-53 pubmed publisher
    ..There is a reduction in the numbers of intrahepatic T cells during the late acute phase in infections that become persistent with significantly fewer of these cells functional in clearing the virus by killing infected hepatocytes...
  40. Tatematsu K, Tanaka Y, Kurbanov F, Sugauchi F, Mano S, Maeshiro T, et al. A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J. J Virol. 2009;83:10538-47 pubmed publisher
    ..Since HBV/J is positioned phylogenetically in between human and ape genotypes, it may help to trace the origin of HBV and merits further epidemiological surveys...
  41. Chai N, Hazan T, Wedlarski R, Rigoulet J. Treatment of a retroperitoneal abscess by omentalization in an orangutan (Pongo pygmaeus pygmaeus). J Zoo Wildl Med. 2009;40:350-3 pubmed
    ..Omentalization was successful in providing continuous fluid drainage for this retroperitoneal abscess and required minimal postoperative handling of the animal...
  42. Coscollá M, Lewin A, Metzger S, Maetz Rennsing K, Calvignac Spencer S, Nitsche A, et al. Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee. Emerg Infect Dis. 2013;19:969-76 pubmed publisher
    ..Exploring this diversity is crucial to the understanding of the biology and evolutionary history of this widespread infectious disease...
  43. Caillaud D, Levrero F, Cristescu R, Gatti S, Dewas M, Douadi M, et al. Gorilla susceptibility to Ebola virus: the cost of sociality. Curr Biol. 2006;16:R489-91 pubmed
  44. Bermejo M, Rodríguez Teijeiro J, Illera G, Barroso A, Vila C, Walsh P. Ebola outbreak killed 5000 gorillas. Science. 2006;314:1564 pubmed
    ..The lag between neighboring gorilla groups in mortality onset was close to the ZEBOV disease cycle length, evidence that group-to-group transmission has amplified gorilla die-offs...
  45. Warren K, Swan R, Hobbs R, Heriyanto -, Kuhn E, Heeney J. Platynosomum fastosum in ex-captive orangutans from Indonesia. J Wildl Dis. 1998;34:644-6 pubmed
    ..Although P. fastosum caused intrahepatic and bile duct damage, death of the hosts could not be attributed solely to the presence of the liver fluke infection...
  46. Klopfleisch R, Langner C, von Felbert I, Rudnick J, Teifke J. Nevus lipomatosus cutaneus superficialis (Hoffmann-Zurhelle) in a chimpanzee (Pan troglodytes). J Med Primatol. 2007;36:57-60 pubmed
    ..After surgical removal, the mass recurred and extended progressively over a period of 5 years...
  47. Nakano T, Murata K, Ikeda Y, Hasegawa H. Growth of Enterobius vermicularis in a chimpanzee after anthelmintic treatment. J Parasitol. 2003;89:439-43 pubmed
    ..This treatment would eradicate male worms first, resulting in females producing only unfertilized eggs, from which only males might hatch...
  48. Drakulovski P, Locatelli S, Butel C, Pion S, Krasteva D, Mougdi Pole E, et al. Use of RNAlater as a preservation method for parasitic coprology studies in wild-living chimpanzees. Exp Parasitol. 2013;135:257-61 pubmed publisher
  49. Lu L, Nakano T, Orito E, Mizokami M, Robertson B. Evaluation of accumulation of hepatitis C virus mutations in a chronically infected chimpanzee: comparison of the core, E1, HVR1, and NS5b regions. J Virol. 2001;75:3004-9 pubmed
    ..In the core and E1 regions, synonymous substitutions predominated and gradually increased over time. However, within the HVR1 region, nonsynonymous substitutions predominated but gradually decreased over time...
  50. Balla Jhagjhoorsingh S, Verschoor E, de Groot N, Teeuwsen V, Bontrop R, Heeney J. Specific nature of cellular immune responses elicited by chimpanzees against HIV-1. Hum Immunol. 2003;64:681-8 pubmed
    ..Here we review the characteristics of the HIV-1-specific cell-mediated immune responses mounted by chimpanzees, and we postulate the mechanisms that have evolved that facilitate their resistance to acquired immunodeficiency syndrome...
  51. Sa nguanmoo P, Thongmee C, Ratanakorn P, Pattanarangsan R, Boonyarittichaikij R, Chodapisitkul S, et al. Prevalence, whole genome characterization and phylogenetic analysis of hepatitis B virus in captive orangutan and gibbon. J Med Primatol. 2008;37:277-89 pubmed publisher
    ..Hepatitis B virus (HBV) is a public health problem worldwide and apart from infecting humans, HBV has been found in non-human primates...
  52. Lawson B, Garriga R, Galdikas B. Airsacculitis in fourteen juvenile southern Bornean orangutans (Pongo pygmaeus wurmbii). J Med Primatol. 2006;35:149-54 pubmed
    ..Airsacculitis is a clinical condition which has been reported in a range of primates species, including orangutans...
  53. Pritzker K. Nonhuman primate seronegative arthritis: probability values for valuable science in a case report. J Rheumatol. 2004;31:2102-3 pubmed