fat body

Summary

Summary: A nutritional reservoir of fatty tissue found mainly in insects and amphibians.

Top Publications

  1. Mackert A, Hartfelder K, Bitondi M, Simões Z. The juvenile hormone (JH) epoxide hydrolase gene in the honey bee (Apis mellifera) genome encodes a protein which has negligible participation in JH degradation. J Insect Physiol. 2010;56:1139-46 pubmed publisher
    ..blot assays using an AmJHEH-specific antibody generated during this study revealed that the AmJHEH found in the fat body shares features with the microsomal JHEHs from several insect species...
  2. Tsichritzis T, Gaentzsch P, Kosmidis S, Brown A, SKOULAKIS E, Ligoxygakis P, et al. A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense. Development. 2007;134:2605-14 pubmed
    ..Drosophila CYLD is broadly expressed during development and, in adult animals, is localized in the fat body, ovaries, testes, digestive tract and specific areas of the nervous system...
  3. Pontes E, Leite P, Majerowicz D, Atella G, Gondim K. Dynamics of lipid accumulation by the fat body of Rhodnius prolixus: the involvement of lipophorin binding sites. J Insect Physiol. 2008;54:790-7 pubmed publisher
    In insects, lipids are stored in the fat body, mainly as triacylglycerol (TAG). In Rhodnius prolixus, a hematophagous hemipteran, lipids are accumulated after blood meal to be used later on...
  4. Juhasz G, Neufeld T. Experimental control and characterization of autophagy in Drosophila. Methods Mol Biol. 2008;445:125-33 pubmed publisher
    ..In the fruit fly, the hepatic/adipose organ known as the fat body accumulates nutrient stores during the larval feeding stage...
  5. Martins J, Nunes F, Sim es Z, Bitondi M. A honeybee storage protein gene, hex 70a, expressed in developing gonads and nutritionally regulated in adult fat body. J Insect Physiol. 2008;54:867-77 pubmed publisher
    ..HEX 70a classifies as an arylphorin since it contains more than 15% of aromatic amino acids. In the fat body of adult workers, hex 70a expression turned out to be a nutrient-limited process...
  6. Scaraffia P, Zhang Q, Thorson K, Wysocki V, Miesfeld R. Differential ammonia metabolism in Aedes aegypti fat body and midgut tissues. J Insect Physiol. 2010;56:1040-9 pubmed publisher
    ..b>Fat body or midgut tissues from female mosquitoes were incubated in an Aedes saline solution supplemented with glucose and ..
  7. Alves S, Serrão J, Melo A. Alterations in the fat body and midgut of Culex quinquefasciatus larvae following exposure to different insecticides. Micron. 2010;41:592-7 pubmed publisher
    This study describes morphological alterations in the fat body and midgut of Culex quinquefasciatus larvae following exposure to different insecticides. To this end, both third and fourth instars of C...
  8. Anand A, Crone E, Zera A. Tissue and stage-specific juvenile hormone esterase (JHE) and epoxide hydrolase (JHEH) enzyme activities and Jhe transcript abundance in lines of the cricket Gryllus assimilis artificially selected for plasma JHE activity: implications for JHE microe. J Insect Physiol. 2008;54:1323-31 pubmed publisher
    b>Fat body and midgut juvenile hormone esterase (JHE) and juvenile hormone epoxide hydrolase (JHEH) specific activities, and plasma JHE activity, were measured throughout the last stadium in two pairs (blocks) of lines of the cricket ..
  9. Wang Y, Brent C, Fennern E, Amdam G. Gustatory perception and fat body energy metabolism are jointly affected by vitellogenin and juvenile hormone in honey bees. PLoS Genet. 2012;8:e1002779 pubmed publisher
    ..Thus, perhaps the bee can make general contributions to the understanding of food-related behavior and metabolic disorders. ..

More Information

Publications115 found, 100 shown here

  1. Mabery E, Schneider D. The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response. J Innate Immun. 2010;2:371-8 pubmed publisher
    ..Here, we show that eiger is made in the fly's fat body during a Salmonella typhimurium infection...
  2. Reis T, Van Gilst M, Hariharan I. A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability. PLoS Genet. 2010;6:e1001206 pubmed publisher
    ..We show that knockdown of Sir2 in the larval fat body results in increased fat levels...
  3. Zhang Y, Zhao P, Liu H, Dong Z, Yang Q, Wang D, et al. The synthesis, transportation and degradation of BmLP3 and BmLP7, two highly homologous Bombyx mori 30K proteins. Insect Biochem Mol Biol. 2012;42:827-34 pubmed
    ..These systematic studies of BmLP3 and BmLP7 reveal their synthesis, transportation and degradation, which could represent the experience of all 30K proteins...
  4. DiAngelo J, Birnbaum M. Regulation of fat cell mass by insulin in Drosophila melanogaster. Mol Cell Biol. 2009;29:6341-52 pubmed publisher
    ..of insulin's positive effects on anabolic lipid metabolism by selectively modulating insulin signaling in the fat body of the fruit fly, Drosophila melanogaster...
  5. Arrese E, Patel R, Soulages J. The main triglyceride-lipase from the insect fat body is an active phospholipase A(1): identification and characterization. J Lipid Res. 2006;47:2656-67 pubmed
    The main triglyceride-lipase (TG-lipase) from the fat body of Manduca sexta has been identified as the homolog of Drosophila melanogaster CG8552...
  6. Lee J, Budanov A, Park E, Birse R, Kim T, Perkins G, et al. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010;327:1223-8 pubmed publisher
  7. Pokrzywa M, Dacklin I, Vestling M, Hultmark D, Lundgren E, Cantera R. Uptake of aggregating transthyretin by fat body in a Drosophila model for TTR-associated amyloidosis. PLoS ONE. 2010;5:e14343 pubmed publisher
    ..These findings suggest that the uptake of TTR from the circulation and its subsequent segregation into cytoplasmic quasi-crystalline arrays of nanospherules is part of a mechanism that neutralizes the toxic effect of TTR. ..
  8. Cruz J, Sieglaff D, Arensburger P, Atkinson P, Raikhel A. Nuclear receptors in the mosquito Aedes aegypti: annotation, hormonal regulation and expression profiling. FEBS J. 2009;276:1233-54 pubmed publisher
    ..family, we have established their expression within the two main reproductive tissues of adult female mosquitoes: fat body and ovary...
  9. Nilsen K, Ihle K, Frederick K, Fondrk M, Smedal B, Hartfelder K, et al. Insulin-like peptide genes in honey bee fat body respond differently to manipulation of social behavioral physiology. J Exp Biol. 2011;214:1488-97 pubmed publisher
    ..However, the major site of insect metabolism and nutrient storage is not the brain, but rather the fat body, where functions of ILP expression are rarely studied and poorly understood...
  10. Roma G, Bueno O, Camargo Mathias M. Chemical detection of the proteins and lipids in the fat body cells from workers of Attini ants (Hymenoptera: Formicidae). Cell Biol Int. 2008;32:406-16 pubmed publisher
    The ultrastructural cytochemistry study and the chemical analysis carried out to examine the fat body of workers of the basal Attini Cyphomyrmex rimosus and Mycetarotes parallelus and the derived Acromyrmex disciger and Atta laevigata ..
  11. García Gil de Muñoz F, Martinez Barnetche J, Lanz Mendoza H, Rodriguez M, Hernández Hernández F. Prostaglandin E2 modulates the expression of antimicrobial peptides in the fat body and midgut of Anopheles albimanus. Arch Insect Biochem Physiol. 2008;68:14-25 pubmed publisher
    ..We identified PGE2 in midgut, fat body, Malpighian tubules, and ovarioles of Anopheles albimanus (Aa) mosquitoes...
  12. Charroux B, Royet J. Drosophila immune response: From systemic antimicrobial peptide production in fat body cells to local defense in the intestinal tract. Fly (Austin). 2010;4:40-7 pubmed
  13. Totten D, Vuong M, Litvinova O, Jinwal U, Gulia Nuss M, Harrell R, et al. Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes. Insect Mol Biol. 2013;22:18-30 pubmed publisher
    As the fat body is a critical tissue for mosquito development, metamorphosis, immune and reproductive system function, the characterization of regulatory modules targeting gene expression to the female mosquito fat body at distinct life ..
  14. Chandrasekar R, Jae S, Krishnan M. Expression and localization of storage protein 1 (SP1) in differentiated fat body tissues of red hairy caterpillar, Amsacta albistriga Walker. Arch Insect Biochem Physiol. 2008;69:70-84 pubmed publisher
    ..The female-specific storage protein 1 (SP1) is the major storage protein found in the hemolymph and fat body of female larvae of the groundnut pest, Amsacta albistriga...
  15. Liu Y, Zhou S, Ma L, Tian L, Wang S, Sheng Z, et al. Transcriptional regulation of the insulin signaling pathway genes by starvation and 20-hydroxyecdysone in the Bombyx fat body. J Insect Physiol. 2010;56:1436-44 pubmed publisher
    ..Tissue distribution analysis showed that most of these genes were highly expressed in the fat body implying that the IIS pathway is functionally important within insect adipose tissue...
  16. Kohyama Koganeya A, Nabetani T, Miura M, Hirabayashi Y. Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila. J Lipid Res. 2011;52:1392-9 pubmed publisher
    ..Using Drosophila as a model animal, we report that GlcT-1 expression in the fat body, which is equivalent to mammalian adipose tissue, regulates energy metabolism...
  17. Bosch J, Sgolastra F, Kemp W. Timing of eclosion affects diapause development, fat body consumption and longevity in Osmia lignaria, a univoltine, adult-wintering solitary bee. J Insect Physiol. 2010;56:1949-57 pubmed publisher
    ..and maintenance during pre-wintering, and tested whether timing of adult eclosion affected fitness by measuring fat body depletion, winter mortality and post-winter longevity...
  18. Juhasz G, Hill J, Yan Y, Sass M, Baehrecke E, Backer J, et al. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol. 2008;181:655-66 pubmed publisher
    ..Vps34 orthologue, causing cell-autonomous disruption of autophagosome/autolysosome formation in larval fat body cells...
  19. Pastor Pareja J, Xu T. Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan. Dev Cell. 2011;21:245-56 pubmed publisher
    ..We found with this method that Collagen IV is synthesized by the fat body, secreted to the hemolymph (insect blood), and continuously incorporated into the BMs of the larva...
  20. Hoffmann J, Romey R, Fink C, Yong L, Roeder T. Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila. Aging (Albany NY). 2013;5:315-27 pubmed
    ..In this study, we tested whether tissue-specific overexpression of Sir2 in the adult fat body can extend lifespan when compared to genetically identical controls...
  21. Colonello Frattini N, Guidugli Lazzarini K, Simões Z, Hartfelder K. Mars is close to venus--female reproductive proteins are expressed in the fat body and reproductive tract of honey bee (Apis mellifera L.) drones. J Insect Physiol. 2010;56:1638-44 pubmed publisher
    ..The finding that the fat body of in honey bee (Apis mellifera) drones synthesizes Vg and is present in hemolymph has long been viewed as a ..
  22. Zhang S, Gunaratna R, Zhang X, Najar F, Wang Y, Roe B, et al. Pyrosequencing-based expression profiling and identification of differentially regulated genes from Manduca sexta, a lepidopteran model insect. Insect Biochem Mol Biol. 2011;41:733-46 pubmed publisher
    ..We obtained 1,821,652 reads with an average length of 289 bp per read from fat body and hemocytes of naïve and microbe-injected M. sexta larvae. After almost all (92...
  23. Lemaitre B, Hoffmann J. The host defense of Drosophila melanogaster. Annu Rev Immunol. 2007;25:697-743 pubmed
    ..Finally, the fat body, a functional equivalent of the mammalian liver, produces humoral response molecules including antimicrobial ..
  24. Patel R, Soulages J, Arrese E. Adipokinetic hormone-induced mobilization of fat body triglyceride stores in Manduca sexta: role of TG-lipase and lipid droplets. Arch Insect Biochem Physiol. 2006;63:73-81 pubmed
    Triglycerides (TG) stores build up in the insect fat body as lipid droplets at times of excess of food. The mobilization of fat body triglyceride (TG) is stimulated by adipokinetic hormones (AKH)...
  25. Liu Y, Sheng Z, Liu H, Wen D, He Q, Wang S, et al. Juvenile hormone counteracts the bHLH-PAS transcription factors MET and GCE to prevent caspase-dependent programmed cell death in Drosophila. Development. 2009;136:2015-25 pubmed publisher
    ..resulted in JH deficiency, pupal lethality and precocious and enhanced programmed cell death (PCD) of the larval fat body. In the fat body of the JH-deficient animals, Dronc and Drice, two caspase genes that are crucial for PCD induced ..
  26. Provost B, Jouan V, Hilliou F, Delobel P, Bernardo P, Ravallec M, et al. Lepidopteran transcriptome analysis following infection by phylogenetically unrelated polydnaviruses highlights differential and common responses. Insect Biochem Mol Biol. 2011;41:582-91 pubmed publisher
    ..the effects of Hyposoter didymator Ichnovirus (HdIV) and Microplitis demolitor Bracovirus (MdBV) on the fat body and hemocyte transcriptome of Spodoptera frugiperda (Lepidoptera: Noctuidae)...
  27. Zhu J, Chen L, Raikhel A. Distinct roles of Broad isoforms in regulation of the 20-hydroxyecdysone effector gene, Vitellogenin, in the mosquito Aedes aegypti. Mol Cell Endocrinol. 2007;267:97-105 pubmed
    ..In particular, the isoform Z2 is required for 20E-mediated activation of Vg, while isoforms Z1 and Z4 serve as repressors to ensure appropriate termination of Vg expression. ..
  28. Schafellner C, Marktl R, Schopf A. Inhibition of juvenile hormone esterase activity in Lymantria dispar (Lepidoptera, Lymantriidae) larvae parasitized by Glyptapanteles liparidis (Hymenoptera, Braconidae). J Insect Physiol. 2007;53:858-68 pubmed
    ..Here we (i) quantified the effects of parasitism on JH esterase (JHE) activity in hemolymph and fat body of penultimate and final instars of L...
  29. Iijima K, Zhao L, Shenton C, Iijima Ando K. Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila. PLoS ONE. 2009;4:e8498 pubmed publisher
    ..form of CREB (DN-CREB), we have examined the effect of blocking CREB activity in neurons and in the fat body, the primary energy storage depot with functions of adipose tissue and the liver in flies, on energy balance, ..
  30. Chell J, Brand A. Nutrition-responsive glia control exit of neural stem cells from quiescence. Cell. 2010;143:1161-73 pubmed publisher
    ..neuroblasts exit quiescence via a hitherto unknown pathway in response to a nutrition-dependent signal from the fat body. We have identified a population of glial cells that produce insulin/IGF-like peptides in response to nutrition, ..
  31. Banerjee K, Ayyub C, Sengupta S, Kolthur Seetharam U. dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies. Aging (Albany NY). 2012;4:206-23 pubmed
    ..In conclusion, these findings highlight the central role that fatbody dSir2 plays in linking metabolism to organismal physiology and its importance for survival...
  32. Min K, Yamamoto R, Buch S, Pankratz M, Tatar M. Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell. 2008;7:199-206 pubmed publisher
    ..Here, we aim to understand this potential overlap. We found that over-expression of dFOXO in head fat body extends lifespan and reduces steady-state mRNA abundance of insulin-like peptide-2 under conditions of high ..
  33. Hiruma K, Riddiford L. Developmental expression of mRNAs for epidermal and fat body proteins and hormonally regulated transcription factors in the tobacco hornworm, Manduca sexta. J Insect Physiol. 2010;56:1390-5 pubmed publisher
    This paper provides a compilation of diagrammatic representations of the expression profiles of epidermal and fat body mRNAs during the last two larval instars and metamorphosis of the tobacco hornworm, Manduca sexta...
  34. Ziegler R, Isoe J, Moore W, Riehle M, Wells M. The putative AKH receptor of the tobacco hornworm, Manduca sexta, and its expression. J Insect Sci. 2011;11:40 pubmed publisher
    ..Here we report the cloning of the full-length cDNA encoding the putative adipokinetic hormone receptor from the fat body of M. sexta...
  35. Chen H, Yin Y, Li Y, Mahmud M, Wang Z. Identification and analysis of genes differentially expressed in the Spodoptera litura fat body in response to the biocontrol fungus, Nomuraea rileyi. Comp Biochem Physiol B Biochem Mol Biol. 2012;163:203-10 pubmed publisher
    ..A forward suppression subtractive hybridization (SSH) cDNA library was constructed from the S. litura fat body and the up-regulated genes were identified to isolate differentially expressed genes in response to N. rileyi...
  36. Deng D, Xu H, Wang F, Duan X, Ma S, Xiang Z, et al. The promoter of Bmlp3 gene can direct fat body-specific expression in the transgenic silkworm, Bombyx mori. Transgenic Res. 2013;22:1055-63 pubmed publisher
    The fat body plays multiple, crucial roles in the life of silkworms...
  37. Brennan C, Delaney J, Schneider D, Anderson K. Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body. Curr Biol. 2007;17:67-72 pubmed
    ..other immune tissues has not been clear, we show that induction of the antibacterial-peptide gene Defensin in the fat body during infection requires blood-cell contributions...
  38. Budatha M, Meur G, Kirti P, Dutta Gupta A. Characterization of Bacillus thuringiensis Cry toxin binding novel GPI anchored aminopeptidase from fat body of the moth Spodoptera litura. Biotechnol Lett. 2007;29:1651-7 pubmed publisher
    ..In this study a partial cDNA encoding aminopeptidase (slfbAPN) was cloned from fat body of the moth Spodoptera litura...
  39. Telfer W. Egg formation in lepidoptera. J Insect Sci. 2009;9:1-21 pubmed publisher
    ..The lepidopteran ovary in turn has contributed much to the understanding of egg formation in insects generally. ..
  40. Tian L, Guo E, Diao Y, Zhou S, Peng Q, Cao Y, et al. Genome-wide regulation of innate immunity by juvenile hormone and 20-hydroxyecdysone in the Bombyx fat body. BMC Genomics. 2010;11:549 pubmed publisher
    ..b>Fat body produces humoral response molecules and hence is considered as the major organ involved in innate immunity...
  41. Birner Gruenberger R, Bickmeyer I, Lange J, Hehlert P, Hermetter A, Kollroser M, et al. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster ?-Esterase-7. Insect Biochem Mol Biol. 2012;42:220-9 pubmed publisher
    ..a functional proteomics approach to identify esterolytic enzymes of the vinegar fly Drosophila melanogaster fat body. One of the fat body carboxylesterases, ?-Esterase-7, was selected for mutational analysis by gene targeting to ..
  42. Lazareva A, Roman G, Mattox W, Hardin P, Dauwalder B. A role for the adult fat body in Drosophila male courtship behavior. PLoS Genet. 2007;3:e16 pubmed
    ..genes are each active in a variety of non-neuronal cell types, they are all prominently expressed in the adult fat body, suggesting an important role for this tissue in behavior...
  43. Shia A, Glittenberg M, Thompson G, Weber A, Reichhart J, Ligoxygakis P. Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes. J Cell Sci. 2009;122:4505-15 pubmed publisher
    In Drosophila, the humoral response characterised by the synthesis of antimicrobial peptides (AMPs) in the fat body (the equivalent of the mammalian liver) and the cellular response mediated by haemocytes (blood cells) engaged in ..
  44. Abdou M, He Q, Wen D, Zyaan O, Wang J, Xu J, et al. Drosophila Met and Gce are partially redundant in transducing juvenile hormone action. Insect Biochem Mol Biol. 2011;41:938-45 pubmed publisher
    ..Precocious and enhanced caspase-dependent programmed cell death (PCD) appears in fat body cells of Met(27) gce(2.5k) during the early larval stages...
  45. Bond N, Nelliot A, Bernardo M, Ayerh M, Gorski K, Hoshizaki D, et al. ßFTZ-F1 and Matrix metalloproteinase 2 are required for fat-body remodeling in Drosophila. Dev Biol. 2011;360:286-96 pubmed publisher
    ..The larval fat body is involved in fueling metamorphosis, and thus it escapes cell death and is instead remodeled during prepupal ..
  46. Auerswald L, Gäde G. Endocrine control of TAG lipase in the fat body of the migratory locust, Locusta migratoria. Insect Biochem Mol Biol. 2006;36:759-68 pubmed
    Aspects of the role and activation of the enzyme triacylglycerol lipase (TAG lipase) in the fat body of the migratory locust Locusta migratoria were investigated...
  47. Budatha M, Meur G, Dutta Gupta A. A novel aminopeptidase in the fat body of the moth Achaea janata as a receptor for Bacillus thuringiensis Cry toxins and its comparison with midgut aminopeptidase. Biochem J. 2007;405:287-97 pubmed
    ..We report here for the first time the presence of a novel APN in the fat body of the moth Achaea janata...
  48. Barchuk A, Figueiredo V, Sim es Z. Downregulation of ultraspiracle gene expression delays pupal development in honeybees. J Insect Physiol. 2008;54:1035-40 pubmed publisher
  49. Wu M, Lu K. Juvenile hormone induction of glutathione S-transferase activity in the larval fat body of the common cutworm, Spodoptera litura (Lepidoptera: Noctuidae). Arch Insect Biochem Physiol. 2008;68:232-40 pubmed publisher
    ..Glutathione S-transferse (GST) activity in the fat body of 0-day-old sixth instar larvae was significantly induced within 12 h of JHA (100 microg/larva) treatment...
  50. Yang H, Zhou Z, Zhang H, Chen M, Li J, Ma Y, et al. Shotgun proteomic analysis of the fat body during metamorphosis of domesticated silkworm (Bombyx mori). Amino Acids. 2010;38:1333-42 pubmed publisher
    ..Among the specific proteins identified in moth fat body, sex-specific storage-protein 1 precursor and chorion protein B8 were unique to the moth stage, indicating that ..
  51. Panaitof S, Scott M. Effect of juvenile hormone on vitellogenin gene expression in the fat body of burying beetles, Nicrophorus orbicollis. Arch Insect Biochem Physiol. 2006;63:82-91 pubmed
    ..200, 300, and 400 microg of methoprene/g beetle to newly eclosed females resulted in up to a 5-fold increase in fat body Vg mRNA levels compared to acetone-treated control females...
  52. Gutierrez E, Wiggins D, Fielding B, Gould A. Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature. 2007;445:275-80 pubmed
    ..In Drosophila, fasting larvae release large quantities of lipid from the fat body but it is unclear how and where this is processed...
  53. Kato T, Park E. Specific expression of GFPuv-beta1,3-N-acetylglucosaminyltransferase 2 fusion protein in fat body of Bombyx mori silkworm larvae using signal peptide. Biochem Biophys Res Commun. 2007;359:543-8 pubmed
    ..mori cells. Therefore, the fusion protein connected to the +16 signal peptide stayed in the fat body of silkworm larvae with biological function, and was not secreted extracellularly.
  54. Xu K, Zheng X, Sehgal A. Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metab. 2008;8:289-300 pubmed publisher
    ..Flies lacking clocks in these tissues, in particular in the fat body, also display increased food consumption but have decreased levels of glycogen and a higher sensitivity to ..
  55. Antonova Y, Alvarez K, Kim Y, Kokoza V, Raikhel A. The role of NF-kappaB factor REL2 in the Aedes aegypti immune response. Insect Biochem Mol Biol. 2009;39:303-14 pubmed publisher
    ..of Drosophila Relish, which is shown to be under the control of the vitellogenin promoter in the mosquito fat body after a blood meal...
  56. Arrese E, Soulages J. Insect fat body: energy, metabolism, and regulation. Annu Rev Entomol. 2010;55:207-25 pubmed publisher
    The fat body plays major roles in the life of insects. It is a dynamic tissue involved in multiple metabolic functions. One of these functions is to store and release energy in response to the energy demands of the insect...
  57. Zou Z, Souza Neto J, Xi Z, Kokoza V, Shin S, Dimopoulos G, et al. Transcriptome analysis of Aedes aegypti transgenic mosquitoes with altered immunity. PLoS Pathog. 2011;7:e1002394 pubmed publisher
    ..Considerable overlap was observed between the fat body transcriptome of Plasmodium-infected mosquitoes and that of mosquitoes with transiently depleted PIAS, an ..
  58. Barat Houari M, Hilliou F, Jousset F, Sofer L, Deleury E, Rocher J, et al. Gene expression profiling of Spodoptera frugiperda hemocytes and fat body using cDNA microarray reveals polydnavirus-associated variations in lepidopteran host genes transcript levels. BMC Genomics. 2006;7:160 pubmed
    ..In this study, we analyzed transcriptional variations in the two main effectors of the insect immune response, the hemocytes and the fat body, after injection of filter-purified HdIV.
  59. Nelliot A, Bond N, Hoshizaki D. Fat-body remodeling in Drosophila melanogaster. Genesis. 2006;44:396-400 pubmed
    The remodeling of the larval fat body is observed in many insects during metamorphosis, but little is known about the physiological importance or the regulation of this process...
  60. Roy S, Hansen I, Raikhel A. Effect of insulin and 20-hydroxyecdysone in the fat body of the yellow fever mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2007;37:1317-26 pubmed
    ..the synergistic action of a steroid hormone and the amino acid/target of rapamycin (TOR) signaling pathway in the fat body. We investigated the role of insulin signaling in the regulation of YPP gene expression...
  61. Bharucha K, Tarr P, Zipursky S. A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis. J Exp Biol. 2008;211:3103-10 pubmed publisher
    The regulation of energy homeostasis is fundamental to all organisms. The Drosophila fat body serves as a repository for both triglycerides and glycogen, combining the energy storage functions of mammalian adipose and hepatic tissues, ..
  62. Kuo T, Pike D, Beizaeipour Z, Williams J. Sleep triggered by an immune response in Drosophila is regulated by the circadian clock and requires the NFkappaB Relish. BMC Neurosci. 2010;11:17 pubmed publisher
    ..Behavioral features of sleep as well as the innate immune response signaling pathways are well characterized in flies and are highly conserved in mammals...
  63. Cruz J, Mané Padrós D, Zou Z, Raikhel A. Distinct roles of isoforms of the heme-liganded nuclear receptor E75, an insect ortholog of the vertebrate Rev-erb, in mosquito reproduction. Mol Cell Endocrinol. 2012;349:262-71 pubmed publisher
    ..distinct roles in regulating the level and timing of expression of key genes involved in vitellogenesis in the fat body (an insect analog of vertebrate liver and adipose tissue) of the mosquito Aedes aegypti...
  64. Ament S, Wang Y, Chen C, Blatti C, Hong F, Liang Z, et al. The transcription factor ultraspiracle influences honey bee social behavior and behavior-related gene expression. PLoS Genet. 2012;8:e1002596 pubmed publisher
    ..Many modules of JH- and maturation-related genes were co-regulated in both the fat body and brain, predicting that usp and cofactors influence shared transcriptional networks in both of these ..
  65. Zhu J, Chen L, Sun G, Raikhel A. The competence factor beta Ftz-F1 potentiates ecdysone receptor activity via recruiting a p160/SRC coactivator. Mol Cell Biol. 2006;26:9402-12 pubmed
    ..Thus, our results reveal the molecular basis of competence for the stage-specific 20E response...
  66. Feng G, Yu Q, Hu C, Wang Y, Yuan G, Chen Q, et al. Apoptosis is induced in the haemolymph and fat body of Spodoptera exigua larvae upon oral inoculation with Spodoptera litura nucleopolyhedrovirus. J Gen Virol. 2007;88:2185-93 pubmed
    ..at 96 h post-inoculation, stained with haematoxylin and eosin, revealed a highly disrupted morphology in the fat body. Apoptosis in fat body tissue was detected using terminal deoxynucleotidyltransferase-mediated fluorescein-dUTP ..
  67. Okamoto N, Yamanaka N, Yagi Y, Nishida Y, Kataoka H, O Connor M, et al. A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila. Dev Cell. 2009;17:885-91 pubmed publisher
    ..which is structurally similar to vertebrate insulin-like growth factor (IGF), is predominantly expressed in the fat body, a functional equivalent of the vertebrate liver and adipocytes...
  68. Sousa Nunes R, Yee L, Gould A. Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature. 2011;471:508-12 pubmed publisher
    ..Organ co-cultures also implicate an unidentified signal from an adipose/hepatic-like tissue called the fat body. Here we provide in vivo evidence that Slimfast amino-acid sensing and Target of rapamycin (TOR) signalling ..
  69. Price D, Nagarajan V, Churbanov A, Houde P, Milligan B, Drake L, et al. The fat body transcriptomes of the yellow fever mosquito Aedes aegypti, pre- and post- blood meal. PLoS ONE. 2011;6:e22573 pubmed publisher
    The fat body is the main organ of intermediary metabolism in insects and the principal source of hemolymph proteins...
  70. Pakkianathan B, Singh N, Krishnan M, König S. A proteomic view on the developmental transfer of homologous 30 kDa lipoproteins from peripheral fat body to perivisceral fat body via hemolymph in silkworm, Bombyx mori. BMC Biochem. 2012;13:5 pubmed publisher
    A group of abundant proteins of ~30 kDa is synthesized in silkworm larval peripheral fat body (PPFB) tissues and transported into the open circulatory system (hemolymph) in a time-depended fashion to be eventually stored as granules in ..
  71. Banerjee K, Ayyub C, Ali S, Mandot V, Prasad N, Kolthur Seetharam U. dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner. Cell Rep. 2012;2:1485-91 pubmed publisher
    ..In this study, we report that Drosophila Sir2 (dSir2) in the adult fat body regulates longevity in a diet-dependent manner...
  72. Lindmo K, Simonsen A, Brech A, Finley K, Rusten T, Stenmark H. A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body. Exp Cell Res. 2006;312:2018-27 pubmed
    ..In insects such as Drosophila, autophagy is developmentally upregulated in the larval fat body prior to metamorphosis...
  73. Yang X, Hou L, Dong D, Shao H, Wang J, Zhao X. Cathepsin B-like proteinase is involved in the decomposition of the adult fat body of Helicoverpa armigera. Arch Insect Biochem Physiol. 2006;62:1-10 pubmed
    ..The decomposition of the adult fat bodies during aging and oogenesis was found to occur via programmed cell death, in which HCB took part...
  74. Burse A, Schmidt A, Frick S, Kuhn J, Gershenzon J, Boland W. Iridoid biosynthesis in Chrysomelina larvae: Fat body produces early terpenoid precursors. Insect Biochem Mol Biol. 2007;37:255-65 pubmed
    ..activity and accumulation of geraniol indicating geranyl diphosphate synthase activity was observed only in the fat body of the iridoid producing larvae in comparison to other larval tissues and to the tested tissues of C. populi...
  75. Bao Y, Lv Z, Liu Z, Xue J, Xu Y, Zhang C. Comparative analysis of Bombyx mori nucleopolyhedrovirus responsive genes in fat body and haemocyte of B. mori resistant and susceptible strains. Insect Mol Biol. 2010;19:347-58 pubmed publisher
    ..mori larvae revealed that the virus invaded the fat body and haemocyte of both KN and 306 strains, which are highly resistant and susceptible, respectively, to BmNPV ..
  76. Wang J, Xia Y. Construction and preliminary analysis of a normalized cDNA library from Locusta migratoria manilensis topically infected with Metarhizium anisopliae var. acridum. J Insect Physiol. 2010;56:998-1002 pubmed publisher
    ..SMART method combined with DSN (duplex-specific nuclease) treatment was constructed using mRNA extracted from the fat body and hemocytes of Locusta migratoria manilensis 6-24h after being topically infected with Metarhizium anisopliae ..
  77. Barth J, Szabad J, Hafen E, Kohler K. Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis. Cell Death Differ. 2011;18:915-24 pubmed publisher
    ..In Drosophila, nutrient depletion induces autophagy in the fat body. Interestingly, nutrient availability and insulin/TOR signaling also influence the size and structure of ..
  78. Havukainen H, Halskau Ø, Skjaerven L, Smedal B, Amdam G. Deconstructing honeybee vitellogenin: novel 40 kDa fragment assigned to its N terminus. J Exp Biol. 2011;214:582-92 pubmed publisher
    ..we establish and compare the molecular properties of vitellogenin from honeybee hemolymph (blood) and abdominal fat body, two compartments that are linked to vitellogenin functions...
  79. Palm W, Sampaio J, Brankatschk M, Carvalho M, Mahmoud A, Shevchenko A, et al. Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition. PLoS Genet. 2012;8:e1002828 pubmed publisher
    ..It is produced as a phospholipid-rich particle by the fat body, and its secretion requires Microsomal Triglyceride Transfer Protein (MTP)...
  80. Bai H, Kang P, Tatar M. Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain. Aging Cell. 2012;11:978-85 pubmed publisher
    ..Here, we show that the insulin-regulated transcription factor dFOXO positively modulates dilp6 mRNA in adult fat body. Over-expression of dilp6 in adult fat body extends lifespan and increases longevity-associated metabolic ..
  81. Hennig K, Colombani J, Neufeld T. TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth. J Cell Biol. 2006;173:963-74 pubmed
    ..Our data indicate that endocytosis acts both as an effector function downstream of TOR and as a physiologically relevant regulator of TOR signaling...
  82. Weake V, Scott M. The non-dosage compensated Lsp1alpha gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes. BMC Mol Biol. 2007;8:35 pubmed
    ..The X-linked Larval serum protein one alpha (Lsp1alpha) gene has long been known to be not dosage compensated. Here we have examined possible explanations for why the Lsp1alpha gene is not dosage compensated...
  83. Cornette R, Matsumoto T, Miura T. Histological analysis of fat body development and molting events during soldier differentiation in the damp-wood termite, Hodotermopsis sjostedti (Isoptera, Termopsidae). Zoolog Sci. 2007;24:1066-74 pubmed publisher
    ..The fat body is involved in the physiological events that prepare the insect for the molting transition...
  84. Hyrsl P, Büyükgüzel E, Büyükgüzel K. Boric acid-induced effects on protein profiles of Galleria mellonella hemolymph and fat body. Acta Biol Hung. 2008;59:281-8 pubmed publisher
    ..were investigated in hemolymph and fat body of final instar (VIIth) and pupae...
  85. Damara M, Gullipalli D, Dutta Gupta A. Cloning and expression of fat body hexamerin receptor and its identification in other hexamerin sequestering tissue of rice moth, Corcyra cephalonica. J Insect Physiol. 2010;56:1071-7 pubmed publisher
    ..Among the various proteins sequestered by the insect fat body, the larval hexamerins form the major group. In the present work full length cDNA (2...
  86. Aguilar Kirigin Á, Naya D. Latitudinal patterns in phenotypic plasticity: the case of seasonal flexibility in lizards' fat body size. Oecologia. 2013;173:745-52 pubmed publisher
    ..Within this framework, here we evaluate the existence of latitudinal patterns in fat body size flexibility--estimated as the difference between maximum and minimum fat body size values observed ..
  87. Lippai M, Csikós G, Maroy P, Lukacsovich T, Juhasz G, Sass M. SNF4Agamma, the Drosophila AMPK gamma subunit is required for regulation of developmental and stress-induced autophagy. Autophagy. 2008;4:476-86 pubmed
    ..We performed a genetic screen to select P-element insertions that affect autophagy in the larval fat body. Light and electron microscopy of one of the isolated mutants (l(3)S005042) revealed the absence of autophagic ..
  88. Liu Y, Liu H, Liu S, Wang S, Jiang R, Li S. Hormonal and nutritional regulation of insect fat body development and function. Arch Insect Biochem Physiol. 2009;71:16-30 pubmed publisher
    The insect fat body is an organ analogue to vertebrate adipose tissue and liver and functions as a major organ for nutrient storage and energy metabolism...
  89. Matova N, Anderson K. Drosophila Rel proteins are central regulators of a robust, multi-organ immune network. J Cell Sci. 2010;123:627-33 pubmed publisher
    ..We find that in addition to their autonomous role in blood-cell survival, Dif and Dorsal also act in the fat body to produce factors that promote blood-cell viability...
  90. Martins G, Serrão J, RAMALHO ORTIGAO J, Pimenta P. Histochemical and ultrastructural studies of the mosquito Aedes aegypti fat body: effects of aging and diet type. Microsc Res Tech. 2011;74:1032-9 pubmed publisher
    ..Despite its epidemiological importance, not much is known regarding cellular and structural changes in the fat body in this mosquito...
  91. Choi I, Hyun S. Conserved microRNA miR-8 in fat body regulates innate immune homeostasis in Drosophila. Dev Comp Immunol. 2012;37:50-4 pubmed publisher
    ..In Drosophila, septic injury by microbial pathogens rapidly induces the production of the AMPs in fat body via well elucidated pathways such as Toll and IMD...
  92. Musselman L, Fink J, Ramachandran P, Patterson B, Okunade A, Maier E, et al. Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. J Biol Chem. 2013;288:8028-42 pubmed publisher
    The Drosophila fat body is a liver- and adipose-like tissue that stores fat and serves as a detoxifying and immune responsive organ...