experimental radiation injuries

Summary

Summary: Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.

Top Publications

  1. Kocer I, Taysi S, Ertekin M, Karslioglu I, Gepdiremen A, Sezen O, et al. The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model. Graefes Arch Clin Exp Ophthalmol. 2007;245:588-94 pubmed
    ..The objective was to determine the antioxidant role of L-carnitine (LC) against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats with a single dose of 5 Gy...
  2. Ryu S, Kolozsvary A, Jenrow K, Brown S, Kim J. Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time. J Neurooncol. 2007;82:119-24 pubmed
    ..This study was to determine the optimum dose and administration time of ramipril for mitigating radiation-induced optic neuropathy...
  3. Dong X, Löfgren S, Ayala M, Söderberg P. Maximum tolerable dose for avoidance of cataract after repeated exposure to ultraviolet radiation in rats. Exp Eye Res. 2007;84:200-8 pubmed
    ..The accumulated threshold dose for damage after two repeated equivalent exposures to UVR-B increases as a function of inter-exposure interval up to at least 30 days inter-exposure interval...
  4. Zhang J, Gong J, Zhang W, Zhu W, Li J. Effects of transplanted bone marrow mesenchymal stem cells on the irradiated intestine of mice. J Biomed Sci. 2008;15:585-94 pubmed publisher
    ..MSCs genetically modified by CXCR4 (the receptor for SDF-1) engrafted into irradiated intestine at a significantly elevated level and ameliorated the intestinal permeability and histopathological damage...
  5. Ossetrova N, Blakely W. Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model. Int J Radiat Biol. 2009;85:837-50 pubmed
    ..The aim was to evaluate the utility of multiple blood-protein biomarkers for early-response assessment of radiation exposure using a murine radiation model system...
  6. Vigneulle R, Rao S, Fasano A, MacVittie T. Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey. Dig Dis Sci. 2002;47:1480-91 pubmed
    ..Our integrated approach allowed a comprehensive study of the relationship between postirradiation tissue injury and changes in function over time in the gastrointestinal tract of the nonhuman primate...
  7. Kim J, Brown S, Kolozsvary A, Jenrow K, Ryu S, Rosenblum M, et al. Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat. Radiat Res. 2004;161:137-42 pubmed
    ..The study represents the first demonstration of prophylaxis of radiation injury by a carboxyl-containing ACE inhibitor, providing a pharmacological strategy designed to reduce radiation-induced normal tissue damage...
  8. Chute J, Fung J, Muramoto G, Erwin R. Ex vivo culture rescues hematopoietic stem cells with long-term repopulating capacity following harvest from lethally irradiated mice. Exp Hematol. 2004;32:308-17 pubmed
    ..High-dose ionizing radiation can cause lethal myeloablation in exposed individuals. We examined whether ex vivo culture could rescue hematopoietic stem cells with repopulating capacity following harvest from lethally irradiated animals...
  9. Rola R, Raber J, Rizk A, Otsuka S, VandenBerg S, Morhardt D, et al. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp Neurol. 2004;188:316-30 pubmed
    ..These data provide evidence that irradiation of young animals induces a long-term impairment of SGZ neurogenesis that is associated with hippocampal-dependent memory deficits...

More Information

Publications112 found, 100 shown here

  1. Park E, Ahn G, Lee N, Kim J, Yun J, Hyun J, et al. Radioprotective properties of eckol against ionizing radiation in mice. FEBS Lett. 2008;582:925-30 pubmed publisher
    ..Thus, we propose eckol as a candidate for adjuvant therapy to alleviate radiation-induced injuries to cancer patients. ..
  2. Kholodova N, Zhavoronkova L, Ryzhov B, Kuznetsova G. [Premature aging of an organism and characteristics of its manifestation in remote period after low dose irradiation]. Adv Gerontol. 2007;20:48-55 pubmed
    ..Data of the experimental study of primates irradiated in dose 1 Gy revealed formation of the brain atrophy in the remote period after low dose radiation exposure. ..
  3. Kim K, Chae H, Kim J, Kim H, Cho Y, Choi W, et al. Thalidomide effect in endothelial cell of acute radiation proctitis. World J Gastroenterol. 2008;14:4779-83 pubmed
    ..003). The mechanisms of acute radiation-induced proctitis in the rats are related to endothelial cell injury of microvessel, which may be attenuated with thalidomide. ..
  4. Varma S, Hegde K. Kynurenine-induced photo oxidative damage to lens in vitro: protective effect of caffeine. Mol Cell Biochem. 2010;340:49-54 pubmed publisher
    ..Further studies on the pharmacological significance of the findings are hence in progress. ..
  5. Jaal J, Richter C, Dorr W. Effect of recombinant human keratinocyte growth factor (Δ23rHuKGF, Palifermin) on inflammatory and immune changes in mouse tongue during fractionated irradiation. Int J Radiat Biol. 2010;86:860-6 pubmed publisher
    ..Palifermin pre-treatment resulted in a long-lasting inhibition of radiation-induced inflammatory and immune changes in mouse tongue. This may contribute to the protective effect of this growth factor. ..
  6. Gevorgyan A, La Scala G, Sukhu B, Leung I, Ashrafpour H, Yeung I, et al. Radiation-induced craniofacial bone growth inhibition: in vitro cytoprotection in the rabbit orbitozygomatic complex periosteum-derived cell culture. Plast Reconstr Surg. 2008;121:763-71 pubmed publisher
    ..This study provides the basis for understanding the cellular mechanisms of radiation-induced craniofacial bone growth inhibition and cytoprotection by amifostine. ..
  7. Sisodia R, Sharma K, Singh S. Acute toxicity effects of Prunus avium fruit extract and selection of optimum dose against radiation exposure. J Environ Pathol Toxicol Oncol. 2009;28:303-9 pubmed
    ..wt/d of PAE for 15 consecutive days before exposure to 10 Gy of gamma-radiation was found to afford maximum protection in terms of body weight and survivability of the mice in comparison to other doses. ..
  8. Thacker P. Can you catch radiation sickness?. Environ Sci Technol. 2006;40:6528 pubmed
  9. Jackson E, Esparza Coss E, Wen X, Ng C, Daniel S, Price R, et al. Magnetic resonance imaging of therapy-induced necrosis using gadolinium-chelated polyglutamic acids. Int J Radiat Oncol Biol Phys. 2007;68:830-8 pubmed
    ..Our data suggest that MR imaging with PG-DTPA-Gd may be a useful technique for noninvasive characterization of treatment-induced necrosis. ..
  10. Para A, Bezjak A, Yeung I, Van Dyk J, Hill R. Effects of genistein following fractionated lung irradiation in mice. Radiother Oncol. 2009;92:500-10 pubmed publisher
    ..There was no evidence that genistein caused protection of small tumors growing in the lung. ..
  11. Hadad I, Johnstone B, Brabham J, Blanton M, Rogers P, Fellers C, et al. Development of a porcine delayed wound-healing model and its use in testing a novel cell-based therapy. Int J Radiat Oncol Biol Phys. 2010;78:888-96 pubmed publisher
    ..Using this model, we showed that a combination of ASCs and PRP improves the healing rates of perfusion-depleted tissues, possibly through enhancing local levels of growth factors. ..
  12. Mizota A, Tanaka M, Kubota M, Negishi H, Watanabe E, Tsuji H, et al. Dose-response effect of charged carbon beam on normal rat retina assessed by electroretinography. Int J Radiat Oncol Biol Phys. 2010;78:1532-40 pubmed publisher
    ..These results indicate that carbon beam irradiation is about two times more damaging than proton beam irradiation on the rat retina at the same dose. ..
  13. Zhou X, Yuan H, Qu W, Ma C, Li H, Wang Y. The study of retinal ganglion cell apoptosis induced by different intensities of microwave irradiation. Ophthalmologica. 2008;222:6-10 pubmed
    ..The cell survival rates were reduced and the earlier apoptosis increased with growing microwave intensity. The 2,450-MHz microwave will cause damage to retinal ganglion cells in a dose-dependent manner. ..
  14. Li S, Yin Z, Chen S, Chen L, Liu Y. Rescue from light-induced retinal degeneration by human fetal retinal transplantation in minipigs. Curr Eye Res. 2009;34:523-35 pubmed
    ..Our data suggest that subretinal transplantation of neuronal retina and RPE might be beneficial in improving retinal function in cases of retinal degeneration. ..
  15. Slama P, Sladek Z, Rysanek D. The thermal treatment effects on bovine blood neutrophil granulocytes apoptosis and necrosis in vitro. Gen Physiol Biophys. 2007;26:118-25 pubmed
    ..25 +/- 3.53% and 0.83 +/- 0.38%; 7.09 +/- 2.07% and 1.64 +/- 0.50%; 35.39 +/- 12.53% and 5.46 +/- 1.46%; after 1, 4 and 24 h incubation, respectively. The temperature (4 degrees C) is the best alternative for short-term storage. ..
  16. Gevorgyan A, La Scala G, Neligan P, Pang C, Forrest C. Radioprotection of craniofacial bone growth. J Craniofac Surg. 2007;18:995-1000 pubmed
    ..This evidence may support future clinical investigations of radioprotector Amifostine or similar substances for radioprotection of the growing craniofacial skeleton. ..
  17. Burlage F, Roesink J, Faber H, Vissink A, Langendijk J, Kampinga H, et al. Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment. Radiother Oncol. 2008;86:347-53 pubmed
  18. Zaichkina S, Rozanova O, Akhmadieva A, Aptikaeva G, Smirnova E, Sorokina S, et al. [Peculiar effects of low doses of high let radiation on mice]. Aviakosm Ekolog Med. 2008;42:22-7 pubmed
    ..Yet, they displayed an exaggerated sensitivity to additional exposure to 1.5 Gy and no AR induction by the standard gamma-protocol which is indicative of genetic instability. ..
  19. Karnaukhova N, Sergievich L, Sorbuchev S, Manokhina I, Rodionov A, Karnaukhov V. [Study of radioprotective effect of "Soma" preparate]. Biofizika. 2007;52:141-6 pubmed
    ..The results show the expediency of further investigation of the Soma radioprotective properties with different concentrations and schemes as well as the necessity of monitoring the immune system during Soma using. ..
  20. Bálentová S, Racekova E, Misúrová E. Effect of paternal exposure to gamma rays on juvenile rat forebrain. Neurotoxicol Teratol. 2007;29:521-6 pubmed
    ..These results suggest that paternal exposure to ionizing radiation induced the genome instability, which manifested itself in the progeny by alteration in proliferative activity or slackening of cell migration in the RMS. ..
  21. Jahnukainen K, Ehmcke J, Nurmio M, Schlatt S. Irradiation causes acute and long-term spermatogonial depletion in cultured and xenotransplanted testicular tissue from juvenile nonhuman primates. Endocrinology. 2007;148:5541-8 pubmed
    ..Our methods are applicable to immature human testis and might serve as powerful tool to study irradiation toxicity in the juvenile human testis. ..
  22. Rakov D, Erofeeva L, Grigorenko D, Abrosimova A, Vorozhtsova S, Muratova M, et al. [The influence of the water with decreased content of heavy stable hydrogen and oxygen (18O) isotope on development of radiation injuries at gamma-radiation in low dose]. Radiats Biol Radioecol. 2006;46:475-9 pubmed
    ..It was manifested in decrease of the degree of gravity of radiation injuries in immune system organs (thymus and spleen), peripheral blood and marrow cells. ..
  23. Jacob A, Shah K, Wu R, Wang P. Ghrelin as a novel therapy for radiation combined injury. Mol Med. 2010;16:137-43 pubmed publisher
    ..We highlight the combined radiation and sepsis model we recently established and suggest the use of ghrelin, a novel gastrointestinal hormone, as a potential therapy for radiation combined injury. ..
  24. Pearlstein R, Higuchi Y, Moldovan M, Johnson K, Fukuda S, Gridley D, et al. Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain. Int J Radiat Biol. 2010;86:145-63 pubmed publisher
    ..We examined the effects of manganese (III) meso-tetrakis (diethyl-2-5-imidazole) porphyrin, a metalloporphyrin antioxidant (MPA), on neural tissue radiation toxicity in vivo and on tumour cell radiosensitivity in vitro...
  25. Wolf N, Pendergrass W, Singh N, Swisshelm K, Schwartz J. Radiation cataracts: mechanisms involved in their long delayed occurrence but then rapid progression. Mol Vis. 2008;14:274-85 pubmed
  26. Zhou F, Chen H, Roper S. Balance of inhibitory and excitatory synaptic activity is altered in fast-spiking interneurons in experimental cortical dysplasia. J Neurophysiol. 2009;102:2514-25 pubmed publisher
    ..This may result in an important class of inhibitory cells that are less able to perform their normal function especially in periods of increased excitatory activity. ..
  27. Wang J, Boerma M, Kulkarni A, Hollenberg M, Hauer Jensen M. Activation of protease activated receptor 2 by exogenous agonist exacerbates early radiation injury in rat intestine. Int J Radiat Oncol Biol Phys. 2010;77:1206-12 pubmed publisher
    ..Pharmacologic PAR(2) antagonists might have the potential to reduce the intestinal side effects of radiotherapy and/or as countermeasures in radiologic accidents or terrorism scenarios. ..
  28. Cetin A, Kaynar L, Kocyigit I, Hacioglu S, Saraymen R, Ozturk A, et al. The effect of grape seed extract on radiation-induced oxidative stress in the rat liver. Turk J Gastroenterol. 2008;19:92-8 pubmed
    ..Grape seed extract may be promising as a therapeutic option in RTx-induced oxidative stress in the rat liver. ..
  29. Liu D, Wang F, Zou Z, Dong S, Shi C, Wang J, et al. Long-term repopulation effects of donor BMDCs on intestinal epithelium. Dig Dis Sci. 2010;55:2182-93 pubmed publisher
    ..Long term, BMDCs could repopulate recipient's intestinal epithelium even without any special treatment, which suggests a novel insight into the maintenance of the intestinal epithelial constitution. ..
  30. Zhang F, Löfgren S, Söderberg P. Interaction of anaesthetic drugs and UV-B irradiation in the anterior segment of the rat eye. Acta Ophthalmol Scand. 2007;85:745-52 pubmed
    ..Xylazine/ketamine anaesthesia induces more proptosis and therefore leads to increased exposure of the cornea and, secondarily, the lens. ..
  31. Rodman D. Proof-of-concept trials for lung stem cell therapy. Proc Am Thorac Soc. 2008;5:731-5 pubmed publisher
    ..While significant hurdles remain, this approach could provide the first interpretable results within 4 years of the decision to proceed, thus greatly accelerating the translation of lung stem cell therapy to humans. ..
  32. Gupta U, Jahan S, Chaudhary R, Goyal P. Amelioration of radiation-induced hematological and biochemical alterations by Alstonia scholaris (a medicinal plant) extract. Integr Cancer Ther. 2008;7:155-61 pubmed publisher
    ..This study showed that ASE protects against radiation-induced hematological and biochemical alterations in Swiss albino mice. ..
  33. Nieder C, Andratschke N, Price R, Kian Ang K. Acceleration of normal-tissue damage expression by early stimulation of cell proliferation in rat spinal cord. Strahlenther Onkol. 2006;182:680-4 pubmed
    ..Further experiments should address different concepts of tissue regeneration or damage prevention. ..
  34. Rajesh A, Sagar R, Kumar R, Sharma A, Prasad J, Singh S, et al. Cytoprotective effect of Podophyllum hexandrum against gamma radiation is mediated via hemopoietic system stimulation and up-regulation of heme-oxygenase-1 and the prosurvival multidomain protein Bcl-2. Integr Cancer Ther. 2007;6:54-65 pubmed
    ..These findings indicate that the bioactive constituents present in REC-2000 exert the radioprotective effect by modulating the hemopoietic system...
  35. Zong Z, Cheng T, Su Y, Ran X, Shen Y, Li N, et al. Recruitment of transplanted dermal multipotent stem cells to sites of injury in rats with combined radiation and wound injury by interaction of SDF-1 and CXCR4. Radiat Res. 2008;170:444-50 pubmed
  36. Wu K, Li Y, Tabassum A, Lu W, Aubert I, Wong C. Loss of neuronal protein expression in mouse hippocampus after irradiation. J Neuropathol Exp Neurol. 2010;69:272-80 pubmed publisher
    ..These changes do not necessarily indicate loss of neurons and indicate the need for caution regarding the use of phenotypic markers such as NeuN to estimate changes in neuronal numbers after irradiation. ..
  37. Buchanan I, Maile R, Frelinger J, Fair J, Meyer A, Cairns B. The effect of burn injury on CD8+ and CD4+ T cells in an irradiation model of homeostatic proliferation. J Trauma. 2006;61:1062-8 pubmed
    ..In addition, CD8+ T cell proliferation appears less reliant on other immune cells than purified CD4+ T cell proliferation. These data reiterate the importance of CD8+ T cells in the initial immune response to burn injury. ..
  38. Hu K, Sun Q, Guo M, Ai H. The radiation protection and therapy effects of mesenchymal stem cells in mice with acute radiation injury. Br J Radiol. 2010;83:52-8 pubmed publisher
    ..MSCs may be a succedaneous or intensive method of haematopoietic stem cell transplantation under certain radiation dosages, and could provide a valuable strategy for acute radiation syndrome. ..
  39. Rutar M, Provis J, Valter K. Brief exposure to damaging light causes focal recruitment of macrophages, and long-term destabilization of photoreceptors in the albino rat retina. Curr Eye Res. 2010;35:631-43 pubmed publisher
    ..Features of the focal and progressive retinal damage in this model are reminiscent of the progression of age-related macular degeneration (AMD). ..
  40. Jaggi J, Seshan S, McDevitt M, Sgouros G, Hyjek E, Scheinberg D. Mitigation of radiation nephropathy after internal alpha-particle irradiation of kidneys. Int J Radiat Oncol Biol Phys. 2006;64:1503-12 pubmed
    ..2 +/- 2.5 mg/dL; p <0.001 vs. placebo controls). Low-dose spironolactone and, to a lesser extent, angiotensin receptor-1 blockade can offer renal protection in a mouse model of internal alpha-particle irradiation. ..
  41. Cai X, Hao J, Zhang X, Yu B, Ren J, Luo C, et al. The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction. Toxicol Appl Pharmacol. 2010;243:27-34 pubmed publisher
  42. Ueno S, Kashimoto T, Susa N, Wada K, Ito N, Takeda Homma S, et al. Estimation of hydroxyl radical generation by salicylate hydroxylation method in multiple organs of mice exposed to whole-body X-ray irradiation. Free Radic Res. 2006;40:944-51 pubmed
    ..Our results clearly demonstrated the usefulness of the salicylate hydroxylation method in estimating hydroxyl radical generation in multiple organs in vivo. ..
  43. Hammond W, Bradley E, Welsh R, Qian J, Weisenberger A, Smith M, et al. A gamma camera re-evaluation of potassium iodide blocking efficiency in mice. Health Phys. 2007;92:396-406 pubmed
    ..These data suggest the need for continued evaluation of the effectiveness of KI as a blocking agent and the application of novel, non-invasive technologies to this important human health issue. ..
  44. Brown J, Hacker H, Schuschereba S, Zwick H, Lund D, Stuck B. Steroidal and nonsteroidal antiinflammatory medications can improve photoreceptor survival after laser retinal photocoagulation. Ophthalmology. 2007;114:1876-83 pubmed
    ..Treatment with systemic methylprednisolone demonstrated improved photoreceptor survival in argon retinal lesions and in nonhemorrhagic Nd:YAG lesions. ..
  45. Cicek E, Gokalp O, Varol R, Cesur G. Influence of electromagnetic fields on bone fracture in rats: role of CAPE. Biomed Environ Sci. 2009;22:157-60 pubmed publisher
    ..Bone fracture was analyzed. Breaking force, bending strength, and total fracture energy decreased in the irradiated groups but increased in the treatment groups. Radiation and CAPE can significantly improve bone. ..
  46. Gorbatov M, Miller J, Yu P, Cringle S, Yu D. Ablation of subretinal tissue with optical fiber delivered 266 nm laser pulses. Exp Eye Res. 2010;91:257-63 pubmed publisher
    ..To perform well controlled laser surgery on subretinal tissues both laser parameters and the properties of the target cells and tissues have to be considered. ..
  47. Suh M, Kwon J, Wee W, Han Y, Kim J, Lee J. Protective effect of ascorbic Acid against corneal damage by ultraviolet B irradiation: a pilot study. Cornea. 2008;27:916-22 pubmed publisher
    ..ASA protected the cornea against UVB irradiation in this pilot study; however, further evaluation using many animals is needed to establish its efficacy. ..
  48. You W, Lin W, Huang J, Hsieh C. Indigowood root extract protects hematopoietic cells, reduces tissue damage and modulates inflammatory cytokines after total-body irradiation: does Indirubin play a role in radioprotection?. Phytomedicine. 2009;16:1105-11 pubmed publisher
    ..Indirubin may play a crucial role, but the underlying mechanism is not very clear and warrants further studies...
  49. Stenkamp D, Satterfield R, Muhunthan K, Sherpa T, Vihtelic T, Cameron D. Age-related cone abnormalities in zebrafish with genetic lesions in sonic hedgehog. Invest Ophthalmol Vis Sci. 2008;49:4631-40 pubmed publisher
    ..The syu(+/-) retinas most likely experience progressive cone photoreceptor loss, accompanied by cone regeneration. Shh signaling may be required to maintain cone viability throughout life. ..
  50. Hu S, Chen Y, Li L, Chen J, Wu B, Zhou X, et al. Effects of adenovirus-mediated delivery of the human hepatocyte growth factor gene in experimental radiation-induced heart disease. Int J Radiat Oncol Biol Phys. 2009;75:1537-44 pubmed publisher
    ..Based on the study findings, hepatocyte growth factor gene transfer can attenuate radiation-induced cardiac injury and can preserve cardiac function. ..
  51. Bensidhoum M, Gobin S, Chapel A, Lemaitre G, Bouet S, Waksman G, et al. [Therapeutic effect of human mesenchymal stem cells in skin after radiation damage]. J Soc Biol. 2005;199:337-41 pubmed
    ..These results open prospects for cellular therapy by MSCs in irradiated epithelial tissues and could be extended to the whole general field of cutaneous cicatrization, particularly after burns...
  52. White D, Fritz J, Hauswirth W, Kaushal S, Lewin A. Increased sensitivity to light-induced damage in a mouse model of autosomal dominant retinal disease. Invest Ophthalmol Vis Sci. 2007;48:1942-51 pubmed
  53. Balli E, Comelekoglu U, Yalin E, Yilmaz N, Aslantas S, Sögüt F, et al. Exposure to gamma rays induces early alterations in skin in rodents: Mechanical, biochemical and structural responses. Ecotoxicol Environ Saf. 2009;72:889-94 pubmed publisher
    ..There were no changes in the epidermis between the irradiated group and the control group ultrastructurally. The results of this study show that the gamma irradiation has a significant effect on normal healthy skin...
  54. Isenberg J, Maxhimer J, Hyodo F, Pendrak M, Ridnour L, DeGraff W, et al. Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury. Am J Pathol. 2008;173:1100-12 pubmed publisher
    ..Therefore, thrombospondin-1/CD47 antagonists may have selective radioprotective activity for normal tissues...
  55. Tian Y, Shi Z, Yang S, Chen Y, Bao S. Changes in myelin basic protein and demyelination in the rat brain within 3 months of single 2-, 10-, or 30-Gy whole-brain radiation treatments. J Neurosurg. 2008;109:881-8 pubmed publisher
  56. Maeda T, Maeda A, Matosky M, Okano K, Roos S, Tang J, et al. Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance. Invest Ophthalmol Vis Sci. 2009;50:4917-25 pubmed publisher
    ..Evaluate the efficacy of potential therapeutics in Rdh8(-/-)Abca4(-/-) mice, a rodent model of human age-related macular degeneration (AMD)...
  57. Meyer L, Löfgren S, Ho Y, Lou M, Wegener A, Holz F, et al. Absence of glutaredoxin1 increases lens susceptibility to oxidative stress induced by UVR-B. Exp Eye Res. 2009;89:833-9 pubmed publisher
    ..In conclusion, the absence of glutaredoxin1 increases lens susceptibility to UVR-B induced oxidative stress in the mouse...
  58. Roach W, Thomas R, Buffington G, Polhamus G, Notabartolo J, DiCarlo C, et al. Simultaneous Exposure Using 532 and 860 nm lasers for visible lesion thresholds in the rhesus retina. Health Phys. 2006;90:241-9 pubmed
    ..6 mW to 17 mW total intraocular power...
  59. Boerma M, Wang J, Richter K, Hauer Jensen M. Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model. Int J Radiat Oncol Biol Phys. 2006;66:552-9 pubmed
    ..This study assessed the protective efficacy of orazipone, a locally-acting small molecule immunomodulator...
  60. Yin J, Huang Z, Wu B, Shi Y, Cao C, Lu Y. Lornoxicam protects mouse cornea from UVB-induced damage via inhibition of NF-{kappa}B activation. Br J Ophthalmol. 2008;92:562-8 pubmed publisher
    ..The COX inhibitors are protective against UVB-induced skin damage. The aim of this study is to determine the effect of lornoxicam, a potent COX inhibitor, on UVB-induced corneal damage and its mechanism in a mouse model...
  61. Eroglu C, Yildiz O, Saraymen R, Soyuer S, Kilic E, Ozcan S. Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats. Clin Invest Med. 2008;31:E182-8 pubmed
    ..To investigate the possible protective effects of aminoguanidine (AG ) on lung damage in whole body irradiated rats...
  62. Shah K, Wu R, Jacob A, Blau S, Ji Y, Dong W, et al. Human ghrelin ameliorates organ injury and improves survival after radiation injury combined with severe sepsis. Mol Med. 2009;15:407-14 pubmed publisher
    ..In conclusion, human ghrelin is beneficial in a rat model of RCI. The protective effect of human ghrelin appears to be attributed to re-balancing the dysregulated sympathetic/parasympathetic nervous systems...
  63. Jenrow K, Brown S, Liu J, Kolozsvary A, Lapanowski K, Kim J. Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus. Radiat Oncol. 2010;5:6 pubmed publisher
    ..Here we investigate the angiotensin converting enzyme (ACE) inhibitor, ramipril, as a mitigator of radiation injury in this context...
  64. Kawashima R, Kawamura Y, Kato R, Mizutani N, Toyama Sorimachi N, Dohi T. IL-13 receptor alpha2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in mice. Gastroenterology. 2006;131:130-41 pubmed
    ..The aim of this study was to clarify the roles of IL-13 receptor alpha2 (IL-13Ralpha2), which is the high-affinity decoy receptor for IL-13, in gastrointestinal tract epithelial cell turnover and repair...
  65. Boerma M, Wang J, Burnett A, Santin A, Roman J, Hauer Jensen M. Local administration of interleukin-11 ameliorates intestinal radiation injury in rats. Cancer Res. 2007;67:9501-6 pubmed
    ..These data show that local administration of rhIL-11 ameliorates early intestinal radiation injury and support further development of rhIL-11 to reduce manifestations of intestinal radiation injury in the clinic...
  66. Gur eva T, Dadasheva O, Tsetlin V, Mednikova E, Lebedeva Z. [Effect of chronic exposure to low doses of ionized radiation on embryonal development of the Japanese quail]. Aviakosm Ekolog Med. 2007;41:20-4 pubmed
    ..On the contrary, the neutron dose of 200 microgy/d imparted by the neutron flux of 30 particles/cm2s was hazardous to embryos as it caused morphological disorders in 12% of embryos...
  67. Hussein M, Abu Dief E, Kamel E, Abou El Ghait A, Abdulwahed S, Ahmad M. Melatonin and roentgen irradiation-induced acute radiation enteritis in Albino rats: an animal model. Cell Biol Int. 2008;32:1353-61 pubmed publisher
    ..Although roentgen rays are widely used for both imaging and therapeutic purposes, our knowledge about the morphological changes associated with radiation enteritis is lacking...
  68. Skourou C, Hoopes P, Paulsen K. Tissue permittivity: a monitor for progressive tissue fibrosis as observed in bystander tissues following experimental high dose rate irradiation. Cancer Biol Ther. 2009;8:2223-9 pubmed
    ..3-8.8 over 11 w post irradiation). These findings mandate further investigation of the relationship between tissue's relative permittivity and subcellular injury leading to fibrosis using electrical impedance spectroscopy (EIS)...
  69. Nakayama F, Hagiwara A, Umeda S, Asada M, Goto M, Oki J, et al. Post treatment with an FGF chimeric growth factor enhances epithelial cell proliferation to improve recovery from radiation-induced intestinal damage. Int J Radiat Oncol Biol Phys. 2010;78:860-7 pubmed publisher
    ..Therefore FGFC was expected to have greater biologic activity in vivo. This study evaluated and compared the protective activity of FGFC and FGF1 against radiation-induced intestinal injuries...
  70. Logvinov S, Plotnikov M, Varakuta E, Zhdankina A, Potapov A, Mikhulya E. Effect of ascovertin on morphological changes in rat retina exposed to high-intensity light. Bull Exp Biol Med. 2005;140:578-81 pubmed
    ..Injection of ascovertin led to disappearance of foci of injuries, limited blood supply disorders in the retina, and destruction of neurosensory and glial cells...
  71. Shi W, Zhao X, Lu T. [Radioprotective effect of catechines against radiation injury in mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2006;26:1621-2 pubmed
    ..To study the radioprotective effect of catechines against radiation injury in mice...
  72. Frisby C, Fraser R, Schirmer M, Yeoh E, Blackshaw L. Roles of muscarinic receptor subtypes in small intestinal motor dysfunction in acute radiation enteritis. Am J Physiol Gastrointest Liver Physiol. 2007;293:G121-7 pubmed
    ..The effect of selective M(3) receptor antagonism suggests that M(3) receptors may provide specific therapeutic targets in acute radiation enteritis...
  73. Zhong Y, Han G, Zhou Y, Peng M, Xie C, Zhou F, et al. [Protection of Angelica sinensis against radiation-induced pulmonary fibrosis in mice]. Zhonghua Yu Fang Yi Xue Za Zhi. 2007;41:105-9 pubmed
    ..To evaluate the Angelica Sinensis as a protecting agent affecting the radiation-induced pulmonary fibrosis in an animal model,..
  74. Wiechmann A, Chignell C, Roberts J. Influence of dietary melatonin on photoreceptor survival in the rat retina: an ocular toxicity study. Exp Eye Res. 2008;86:241-50 pubmed
    ..Chronic exposure to natural or artificial light and simultaneous intake of melatonin may potentially contribute to a significant loss of photoreceptor cells in the aging retina...
  75. Brozmanova M, Javorkova N, Hajtmanova E, Zamecnik L, Javorka M, Hanacek J, et al. Influence of chest gamma-irradiation on cough response in awake guinea pigs. J Physiol Pharmacol. 2007;58 Suppl 5:67-74 pubmed
    ..An increase of CRI also was found inside the XRT group on the 10th day after irradiation compared with the pre-irradiation value of CRI...
  76. Pang Q, Wang P, Wang J, Wang W, Wang J, Yuan Z. Basic research of the relationship between irradiation dose and volume in radiation-induced pulmonary injury. Chin Med J (Engl). 2009;122:1929-34 pubmed
    ..The study investigated the relationships between the irradiation dose and volume in radiation-induced lung injury by setting up a model of graded volume irradiation of the rat lung...
  77. Laabich A, Vissvesvaran G, Lieu K, Murata K, McGinn T, Manmoto C, et al. Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture. Invest Ophthalmol Vis Sci. 2006;47:3156-63 pubmed
    ..The present study was performed to investigate the effect of crocin on blue light- and white light-induced rod and cone death in primary retinal cell cultures...
  78. Samardzija M, Wenzel A, Thiersch M, Frigg R, Reme C, Grimm C. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2006;47:5181-90 pubmed
    ..Thus, caspase-1 may be proapoptotic in the retina. To test directly the role of caspase-1 in photoreceptor apoptosis, three mouse models were analyzed for retinal degeneration in the presence or absence of caspase-1...
  79. Fedorenko B, Petrov V, Smirnova O, Vorozhtsova S, Abrosimova A. [Experimental studies of the relative biological effectiveness of accelerated charged particles varying in energy]. Aviakosm Ekolog Med. 2006;40:55-63 pubmed
    ..Consideration is given to factors that may modify RBE values estimated for different types of radiation...
  80. Adaramoye O, Ogungbenro B, Anyaegbu O, Fafunso M. Protective effects of extracts of Vernonia amygdalina, Hibiscus sabdariffa and vitamin C against radiation-induced liver damage in rats. J Radiat Res. 2008;49:123-31 pubmed
    ..Taken together, the results suggest that the extracts of VA and HS, and VIT C could increase the antioxidant defense systems and may probably protect animals from radiation-induced liver damage...
  81. Hosseinimehr S, Zakaryaee V, Ahmadi A, Akhlaghpoor S. Radioprotective effects of chlorogenic acid against mortality induced by gamma-irradiation in mice. Methods Find Exp Clin Pharmacol. 2008;30:13-6 pubmed publisher
    ..It appeared that chlorogenic acid with antioxidant activity reduced mortality induced by gamma-irradiation...
  82. Dynlacht J, Valluri S, Lopez J, Greer F, DesRosiers C, Caperell Grant A, et al. Estrogen protects against radiation-induced cataractogenesis. Radiat Res. 2008;170:758-64 pubmed publisher
    ..These data have important implications for astronauts and radiotherapy patients...
  83. Ghosh S, Zhang R, Fish B, Semenenko V, Li X, Moulder J, et al. Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis. Int J Radiat Oncol Biol Phys. 2009;75:1528-36 pubmed publisher
    ..To find the mitigators of pneumonitis induced by moderate doses of thoracic radiation (10-15 Gy)...
  84. Janssen W, Muldrow A, Kearns M, Barthel L, Henson P. Development and characterization of a lung-protective method of bone marrow transplantation in the mouse. J Immunol Methods. 2010;357:1-9 pubmed publisher
    ..This system may be applicable to other organ systems in which protection from radiation during bone marrow transplantation is desired...
  85. Uckun F, Dibirdik I, Qazi S. Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase. Arzneimittelforschung. 2010;60:218-25 pubmed publisher
    ..6 +/- 4.3 mm3 vs. 3.2 +/- 0.9 mm3 at 20 weeks, P < 0.05). These experimental findings provide unprecedented evidence that WHI-P131 may be useful as a chemopreventive agent against NMSC...
  86. Haase M, Klawitter A, Geyer P, Baretton G. Expression of the immunomodulator IL-10 in type I pneumocytes of the rat: alterations of IL-10 expression in radiation-induced lung damage. J Histochem Cytochem. 2007;55:1167-72 pubmed
    ..These cells have the potential to act in a pro-inflammatory way by tumor necrosis factor alpha and also in a pro-fibrotic way by activating TH2 cytokines...
  87. Gauter Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Batinic Haberle I, Vujaskovic Z. Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic Biol Med. 2008;44:982-9 pubmed
    ..However, MnTE-2-PyP5+ at 6 mg/kg proved to be more effective in reducing expression of key molecular factors known to play an important role in radiation-induced lung injury...
  88. Fujimori A, Yaoi T, Ogi H, Wang B, Suetomi K, Sekine E, et al. Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans. Biochem Biophys Res Commun. 2008;369:953-7 pubmed publisher
    ..A similar suppression was observed in the irradiated neurosphere cultures. This is the first report suggesting that the suppression of Aspm by IR could be the initial molecular target leading to the future microcephaly formation...
  89. Jiang J, Ma Z, Liu Y. [Expression of aquaporin-4 protein in rats with acute radiation-induced cerebral edema]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008;33:252-6 pubmed
    ..To explore the relation between changes in expression of aquaporin-4(AQP4) protein and acute radiation-induced cerebral edema after Gamma knife radiation...
  90. Semont A, Mouiseddine M, Francois A, Demarquay C, Mathieu N, Chapel A, et al. Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis. Cell Death Differ. 2010;17:952-61 pubmed publisher
    ..Our results suggest that MSC infusion may be used as a therapeutic treatment to limit radiation-induced GIT damage...
  91. Yamamoto K, Kureyama N, Asano K, Ikeda T, Yamatodani A. Involvement of substance P and the neurokinin-1 receptor in radiation-induced hair loss in mice. J Pharmacol Sci. 2010;112:118-20 pubmed
    ..These results indicated that gamma irradiation-induced hair loss was mediated by SP via NK(1)R...
  92. Kiang J, Jiao W, Cary L, Mog S, Elliott T, Pellmar T, et al. Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection. Radiat Res. 2010;173:319-32 pubmed publisher
    ..Agents that inhibit these responses may prove to be therapeutic for combined injury and may reduce related mortality...