animal disease models

..Recent development of animal disease models now opens the opportunity to delineate the disease more precisely and develop therapies targeting the ..

..interferon analogs that are significantly more efficacious than a leading commercial beta interferon in animal disease models. The goals of this Phase II continuing renewal proposal are to manufacture the protein under GLP (Good ..

..manufacturing process and produce sufficient quantities of PEGylated recombinant sFlt-1 for testing in animal disease models of RA...

..manufacturing process and produce sufficient quantities of PEGylated recombinant sFlt-1 for testing in animal disease models of RA...

..PRP) can be used for long-term monitoring of ex-vivo genetically engineered therapeutic cells in small animal disease models and then in human patients...

..has been confined largely to cell culture studies, with limited methods for in vivo administration in animal disease models such as NSCLC xenograft tumor models, and none available as a research reagent...

..As a result of this success, the therapeutic potential of siRNA is being actively investigated in animal disease models and in humans...

..Developmental biology studies at the University of Chicago include the generation of animal disease models, studies of cancer and stem cell biology, as well as research into the underlying basis of birth defects ..

..to many inflammatory stimuli, and that there is differential control of these molecules in several animal disease models. This control is critical because inflammatory reactions that are disproportionate to the magnitude of the ..

..processes to produce sufficient quantities of the modified B-interferon proteins for testing in animal disease models. In a clinical setting, the improved characteristics of the novel B-interferon proteins may reduce the ..

..will be a table-top computerized tomographic imaging system for use in research laboratories using small animal disease models with per frame exposure times of a few seconds...

..pursued as a very active research area over the last decade and a remarkable progress has been obtained in animal disease models. To further develop cell-based therapies into the clinic, noninvasive cellular imaging techniques are ..

..albicans morphological forms, during cell mating, and on fungal cells from various animal disease models. We will also use the antibodies to support our conclusions about the role of Als proteins in C...

..Although both large and small animal disease models currently exist and are readily being developed for various human diseases, the use of small animals (e.g...

..to provide tissue quantitation of biologically specific radiopharmaceuticals required in small animal disease models. Imaging using PET radionuclides has become a remarkably useful translational tool for UW/FHCRC ..

..Although both large and small animal disease models currently exist and are readily being developed for various human diseases, the use of small animals (e.g...

..Such a versatile system should find wide applications in biology from in vivo cell trafficking, tumor metastasis, small animal disease models, transgenic mice, drug screenings in mice, to in vivo gene function and regulation study.

..Although calpain inhibitors have shown early promise in small animal disease models, very little is known about the targets of calpain proteases and whether calpains contribute to ..

..here is to develop more potent derivatives of VMD-C620 and study them in preclinical pharmacokinetic and animal disease models relevant to alcohol use disorders...

..here is to develop more potent derivatives of VMD-C620 and study them in preclinical pharmacokinetic and animal disease models relevant to alcohol use disorders...

..studying and manipulating a wide range of intracellular processes, both in vitro and in vivo, including animal disease models. In Specific Aim 1, we will examine whether imported Bsecretase substrate peptides can inhibit the ..

..Therefore, whether RNAi can serve as an alternative to gene knockout technology to generate animal disease models and to investigate molecular pathways in vivo is unclear...

..2. Apply bioinformatics tools to find gene regulation networks in animal disease models and human patient samples. 3. Map mutant genes and develop a reverse genetic strategy for zebrafish. ..

..2. Apply bioinformatics tools to find gene regulation networks in animal disease models and human patient samples. 3. Map mutant genes and develop a reverse genetic strategy for zebrafish.

..by PP14; and 3) to design recombinant derivatives of PP14 with enhanced functions, and to explore their therapeutic use in autoimmune and alloimmune animal disease models. The proposed studies combine basic and applied features.

..Further, VEGF is likely to promote neuroprotection indirectly by activating the proliferation of glia and by promoting angiogenesis. Our results support a potential neuroprotective role for VEGF in the treatment of Parkinson's disease...

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..Our finding that Nogo A is involved in CNS autoimmune demyelination indicates that this molecule may have a far more complex role than has been previously anticipated...

..Furthermore, these data suggest that the mechanism of action for GW405833 does not depend on the release of endogenous opioids...

..AC model (lauric acid diethanolamine and pentachlorophenol). These results show that these transgenic models do not respond to many chemicals that show strain- or species-specific responses in conventional bioassays...

..These results may account for the discrepancies among previous studies which used different inhibitors and different models of neurotoxicity...

..From these experiments, the neuroprotective activity of minocycline appears more related to its antiinflammatory activity than to a direct beneficial action on mitochondria...

..Taken together, our study demonstrates considerable species differences in inflammatory gene induction after focal brain ischemia...

..Drugs generating high NO concentrations, however, intensify pain via a guanylate cyclase-independent mechanism...

..Of the groups studied, male C57/BL6 mice develop the most inflammation and necrosis, lipid peroxidation, and ultrastructural injury, and best approximate the histological features of NASH...

..Although these observations suggest structural alterations at the BBB, they do not support the concept of extensive BBB damage with substantial increases in BBB permeability in Alzheimer's disease...

..01). These coherent findings indicate that relaxin regulates fibroblast proliferation, differentiation, and collagen deposition and may have therapeutic potential in diseased states characterized by cardiac fibrosis...

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..These findings indicate that tPA acts on a substrate other than plasminogen and that the effects of neuroserpin on seizure progression and neuronal cell survival are mediated through the inhibition of tPA...

..P-gp alterations significantly affect antiepileptic drugs concentrations in the brain, suggesting that seizure-induced mdr mRNA expression contributes to MDR in epilepsy...

..Rats treated intratracheally with LPS generate lipid-derived free radicals via activation of NADPH oxidase...

..These data add to the mounting evidence suggesting that neurotrophic factors act indirectly through Müller cells to promote photoreceptor survival...

..The purpose of this article is to update information regarding animal models in the pathogenesis of NAFLD...

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..Therefore, these results suggest that NAC and OTC can be used as potential agents to prevent the progression of PD...

..These results indicate that E5564 is a potent antagonist of LPS and lacks agonistic activity in human and animal model systems, making it a potentially effective therapeutic agent for treatment of disease states caused by endotoxin...

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..These results indicate that an animal model of GNCSE can be generated and that even in the absence of overt neuronal damage, GNCSE may produce functional changes in neurons that alter electrical excitability of neural circuits...

..In these hyperlipidaemic animal models, PPARgamma ligands failed to show any significant efficacy. Taken together, ragaglitazar shows better insulin-sensitizing and lipid-lowering potential, as compared to the standard compounds...

..Therefore, we propose that AMPA receptor potentiators offer the potential of a new therapy to halt the progression and perhaps repair the degeneration in Parkinson's disease...

..Although the mechanism of action underlying this retinoprotection remains to be clarified, NAM may be a potential therapeutic agent for the treatment of retinal degeneration...

..v., 5 min after occlusion; 30 mg/kg, s.c., 1 and 4 h post-middle cerebral artery occlusion) decreased infarct size by 42%. The consistent anti-ischemic effects of ACEA 1021 make it a valuable compound for exploratory stroke research...

..It also reduced the paw edema induced by carrageenan in rats. In addition, it potently attenuated pyrexia induced by lipopolysaccharide...

..These observations suggest that microglia regulate the microglia-Müller glia-photoreceptor network that serves as a trophic factor-controlling system during retinal degeneration...

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..TCB was required for bilirubin degradation by CYP1A1. Manipulation of CYP1A2 may be of therapeutic benefit in patients with these diseases of bilirubin conjugation...

..These findings also support the use of IGF-I as a therapeutical aid in brain diseases coursing with either acute or progressive neuronal death...

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..These results emphasize that SHP1 as a part of different signaling pathways plays an important role in the global regulation of astrocytic and microglial activation in the normal and injured CNS...

..This potential bias in assessing extent of neurotoxin-induced lesion and subsequent protection by pharmacological manipulation prompts us to call for caution in setting up experimental designs...

..This was associated with decreased postischemic superoxide-mediated oxidative stress...

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..These studies demonstrate that targeted PEGylation greatly alters the pharmacokinetic and pharmacodynamic properties of Shh, resulting in a form with improved pharmaceutical properties...

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..The content or activities of almost all other enzymes examined in the present study do not appear to be affected by the gene manipulation...

..In conclusion, calpain 10 seems to be a ubiquitous calpain, the expression level and subcellular distribution of which are dynamically influenced by calcium...

..Double transgenic mice with inducible expression of survival factors provide valuable tools for selection of survival factor candidates for gene therapy...

..These results suggest that PARP-1 activation is a major factor mediating hypoglycemic neuronal death and that PARP-1 inhibitors can rescue neurons that would otherwise die after severe hypoglycemia...

..Thus, a newly synthesized compound, JTV-926 induced t-PA release from vascular endothelial cells and effective thrombolysis in vivo...

..Naloxone (0.5 mg/kg i.p.) significantly inhibited the antidiarrhoeal activity of the extract as well as loperamide, thus indicating a role of the opioid system in the antidiarrhoeal activity of the extract...

..Therefore, the results obtained in this study suggest that alpha-spinasterol has a significant therapeutic potential to modulate the development and/or progression of diabetic nephropathy...

..These data indicate the salutary effects of EGF by attenuating internal complications associated to thermal injuries. Further studies are warranted to fully elucidate the usefulness of this therapy...

..This observation has importance for understanding the complex role of inflammatory cytokines in autoimmunity...

..These results suggest that both the TH2 cytokines IL-4 and IL-5 and the TH1 cytokine IFN-gamma play important roles in the inflammation and hypertrophy of the skin in AD...

..In the aorta, EL was higher in EKO than in wild-type mice, and cholesterol feeding had no effect. Together, these data suggest that EL may be upregulated at the site of atherosclerotic lesions and thus could supply lipids to the area...

..Therefore, it may represent a good animal model for the study of idiosyncratic drug reactions...

..One possible mechanism may result from AS-thrombin interaction...

..CONCLUSIONS: These results indicate that PDGFR-beta plays a significant role in formation of fibrous atherosclerotic lesions and that regulation of the signal transduction through PDGFR-beta could affect atherogenesis in mice...

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