pragmatic clinical trials as topic


Summary: Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts.

Top Publications

  1. Clement C, Rapport F, Seagrove A, Alrubaiy L, Williams J. Healthcare professionals' views of the use and administration of two salvage therapy drugs for acute ulcerative colitis: a nested qualitative study within the CONSTRUCT trial. BMJ Open. 2017;7:e014512 pubmed publisher
    ..isrctn 22663589. ..
  2. Messier S, Callahan L, Beavers D, Queen K, Mihalko S, Miller G, et al. Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial. BMC Musculoskelet Disord. 2017;18:91 pubmed publisher Identifier: NCT02577549 October 12, 2015. ..
  3. Hernandez A, Fleurence R, Rothman R. The ADAPTABLE Trial and PCORnet: Shining Light on a New Research Paradigm. Ann Intern Med. 2015;163:635-6 pubmed publisher
  4. Khozin S, Blumenthal G, Pazdur R. Real-world Data for Clinical Evidence Generation in Oncology. J Natl Cancer Inst. 2017;109: pubmed publisher
    ..Conducting valid real-world studies requires data quality assurance through auditable data abstraction methods and new incentives to drive electronic capture of clinically relevant data at the point of care...
  5. Groenwold R, Dekkers O. Designing pragmatic trials-what can we learn from lessons learned?. J Clin Epidemiol. 2017;90:3-5 pubmed publisher
    ..However, it is yet unclear how e.g., possible dependencies between PRECIS domains, or conducting a pragmatic trial within an existing data registry (e.g., electronic health records) affect the applicability of the tool. ..
  6. Forbes G, Loudon K, Treweek S, Taylor S, Eldridge S. Understanding the applicability of results from primary care trials: lessons learned from applying PRECIS-2. J Clin Epidemiol. 2017;90:119-126 pubmed publisher
    ..For some cluster-randomized trials, greater insight may be gained by plotting two PRECIS-2 wheels, one at the individual participant level and another at the cluster level. ..
  7. Welsing P, Oude Rengerink K, Collier S, Eckert L, van Smeden M, Ciaglia A, et al. Series: Pragmatic trials and real world evidence: Paper 6. Outcome measures in the real world. J Clin Epidemiol. 2017;90:99-107 pubmed publisher
    ..Therefore, this should be discussed with all stakeholders as early as feasible to ensure the relevance of study results for decision making in clinical practice and the ability to perform the study. ..
  8. Ford I, Norrie J. Pragmatic Trials. N Engl J Med. 2016;375:454-63 pubmed publisher
  9. Nayak R, Wendler D, Miller F, Kim S. Pragmatic Randomized Trials Without Standard Informed Consent?: A National Survey. Ann Intern Med. 2015;163:356-64 pubmed publisher
    ..Time-sharing Experiments for the Social Sciences and Intramural Research Program of the National Institutes of Health Clinical Center. ..

More Information


  1. Lund L, Oldgren J, James S. Registry-Based Pragmatic Trials in Heart Failure: Current Experience and Future Directions. Curr Heart Fail Rep. 2017;14:59-70 pubmed publisher
  2. Weinfurt K, Bollinger J, Brelsford K, Bresciani M, Lampron Z, Lin L, et al. Comparison of Approaches for Notification and Authorization in Pragmatic Clinical Research Evaluating Commonly Used Medical Practices. Med Care. 2017;55:970-978 pubmed publisher
    ..Data from this study provide a starting point to developing solutions to these surprisingly complex issues. ..
  3. Kim S, Miller F. Informed consent for pragmatic trials--the integrated consent model. N Engl J Med. 2014;370:769-72 pubmed publisher
  4. Williams H, Burden Teh E, Nunn A. What is a pragmatic clinical trial?. J Invest Dermatol. 2015;135:1-3 pubmed publisher
  5. Carcas A, Abad Santos F, Sánchez Perruca L, Dal Ré R. [Electronic medical record in clinical trials of effectiveness of drugs integrated in clinical practice]. Med Clin (Barc). 2015;145:452-7 pubmed publisher
  6. Johnson K, Tachibana C, Coronado G, Dember L, Glasgow R, Huang S, et al. A guide to research partnerships for pragmatic clinical trials. BMJ. 2014;349:g6826 pubmed publisher
  7. Zuidgeest M, Welsing P, van Thiel G, Ciaglia A, Alfonso Cristancho R, Eckert L, et al. Series: Pragmatic trials and real world evidence: Paper 5. Usual care and real life comparators. J Clin Epidemiol. 2017;90:92-98 pubmed publisher
    ..The specific objectives of the trial and design choices should be discussed with all stakeholders to realize the full potential of the pragmatic trial. ..
  8. Sugarman J, Califf R. Ethics and regulatory complexities for pragmatic clinical trials. JAMA. 2014;311:2381-2 pubmed publisher