clinical studies as topic


Summary: Works about research studies that evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies.

Top Publications

  1. Kymionis G, Kontadakis G, Hashemi K. Accelerated versus conventional corneal crosslinking for refractive instability: an update. Curr Opin Ophthalmol. 2017;28:343-347 pubmed publisher
    ..Accelerated CXL protocols seem to be a valid alternative to the conventional protocol; however, more comparative long term studies are needed to confirm the validity and to elucidate which accelerated protocol is ideal in each case. ..
  2. Abraham H, Wolfson L, Moscufo N, Guttmann C, Kaplan R, White W. Cardiovascular risk factors and small vessel disease of the brain: Blood pressure, white matter lesions, and functional decline in older persons. J Cereb Blood Flow Metab. 2016;36:132-42 pubmed
  3. Wallin A, Nordlund A, Jonsson M, Blennow K, Zetterberg H, Öhrfelt A, et al. Alzheimer's disease--subcortical vascular disease spectrum in a hospital-based setting: Overview of results from the Gothenburg MCI and dementia studies. J Cereb Blood Flow Metab. 2016;36:95-113 pubmed
    ..Our findings may contribute to better healthcare for this underrecognized group of patients. The Gothenburg MCI study has also published papers on multimodal prediction of dementia, and cognitive reserve. ..
  4. Zijlstra J, Burggraaff C, Kersten M, Barrington S. FDG-PET as a biomarker for early response in diffuse large B-cell lymphoma as well as in Hodgkin lymphoma? Ready for implementation in clinical practice?. Haematologica. 2016;101:1279-1283 pubmed
  5. Evoniuk G, Mansi B, DeCastro B, Sykes J. Impact of study outcome on submission and acceptance metrics for peer reviewed medical journals: six year retrospective review of all completed GlaxoSmithKline human drug research studies. BMJ. 2017;357:j1726 pubmed publisher
    ..Sponsors and journal editors should share similar information to contribute to better understanding of issues and barriers to full transparency. ..
  6. Zhang S, Wang Y, Li W. [Application of tipping-point analysis to address missing data in clinical studies]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38:674-678 pubmed publisher
    ..05????????????????????????????????????????????????????????????????p<0.05??????93.6%?????????????????????????p<0.05??????29.7%??????????????????????????????????????????????????????. ..
  7. Yan Z, Chen Z, Ma C. Liposomal bupivacaine versus interscalene nerve block for pain control after shoulder arthroplasty: A meta-analysis. Medicine (Baltimore). 2017;96:e7226 pubmed publisher
    ..However, studies with more patients and better-designed methods are needed to establish the optimal regimen and the safety of liposomal bupivacaine in TSA patients. ..
  8. Gajewski J, Rosier P, Rahnama i S, Abrams P. Do we assess urethral function adequately in LUTD and NLUTD? ICI-RS 2015. Neurourol Urodyn. 2017;36:935-942 pubmed publisher
    ..Neurourol. Urodynam. 36:935-942, 2017. © 2017 Wiley Periodicals, Inc. ..
  9. Buske C, Ogura M, Kwon H, Yoon S. An introduction to biosimilar cancer therapeutics: definitions, rationale for development and regulatory requirements. Future Oncol. 2017;13:5-16 pubmed publisher
    ..The path to approval is discussed with reference to the rituximab biosimilar CT-P10, the first licensed monoclonal antibody biosimilar cancer therapeutic. ..

More Information


  1. Murray I, Geeslin A, Goudie E, Petrigliano F, LaPrade R. Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO): Platelet-Rich Plasma and Mesenchymal Stem Cells. J Bone Joint Surg Am. 2017;99:809-819 pubmed publisher
    ..These checklists provide specifications for the minimum information that should be reported by clinical studies evaluating PRP or MSCs. ..
  2. Zhang Y, Zhang J, Wang B. Efficacy of tranexamic acid plus drain-clamping to reduce blood loss in total knee arthroplasty: A meta-analysis. Medicine (Baltimore). 2017;96:e7363 pubmed publisher
    ..Because the number and the quality of the included studies were limited, more high-quality randomized controlled trials are needed to identify the optimal dose of TXA and the clamping hours in patients prepared for TKA. ..
  3. Ho P, Koendgen H, Campbell N, Haddock B, Richman S, Chang I. Risk of natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: a retrospective analysis of data from four clinical studies. Lancet Neurol. 2017;16:925-933 pubmed publisher
    ..We aimed to calculate PML risk estimates from patient-level risk-factor data and to stratify risk by concentrations of anti-JCV antibody in serum (anti-JCV antibody index)...
  4. Marais B, Heemskerk A, Marais S, van Crevel R, Rohlwink U, Caws M, et al. Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies. Clin Infect Dis. 2017;64:501-509 pubmed publisher
  5. Brignole Baudouin F, Riancho L, Ismail D, Deniaud M, Amrane M, Baudouin C. Correlation Between the Inflammatory Marker HLA-DR and Signs and Symptoms in Moderate to Severe Dry Eye Disease. Invest Ophthalmol Vis Sci. 2017;58:2438-2448 pubmed publisher
    ..Its expression by conjunctival cells has the potential to serve as a biomarker, bridging signs and symptoms in clinical research in DED, but there is still a need for additional validation studies. ..
  6. Gillespie M, Benson L, Bergersen L, Bacha E, Cheatham S, Crean A, et al. Patient Selection Process for the Harmony Transcatheter Pulmonary Valve Early Feasibility Study. Am J Cardiol. 2017;120:1387-1392 pubmed publisher
    ..The initial clinical evaluation of this technology was unique, and the highly variable anatomy of this population required careful screening to ensure acceptable device fit. ..
  7. Shea B, Reeves B, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017;358:j4008 pubmed publisher