oncogene protein v crk


Summary: A signal transducing adaptor protein that is encoded by the crk ONCOGENE from TYPE C AVIAN RETROVIRUSES. It contains SRC HOMOLOGY DOMAINS and is closely related to its cellular homolog, PROTO-ONCOGENE PROTEIN C-CRK.

Top Publications

  1. Hasegawa H, Senga T, Ito S, Iwamoto T, Hamaguchi M. A role for AP-1 in matrix metalloproteinase production and invadopodia formation of v-Crk-transformed cells. Exp Cell Res. 2009;315:1384-92 pubmed publisher
    ..Taken together, AP-1 appears to play a critical role in the production of MMP-2 and MMP-9 and invadopodia formation of v-Crk-transformed cells. ..
  2. Yeo M, Song W. v-Crk regulates membrane dynamics and Rac activation. Cell Adh Migr. 2008;2:174-6 pubmed
    ..It thus appears that v-Crk/Rac1 signaling contributes to the regulation of membrane dynamics and cell migration, and that v-Crk is an effector molecule for Rac1 activation that regulates cell motility. ..